3,412 results match your criteria Respirology[Journal]


Urine metabolic profiles in paediatric asthma.

Respirology 2019 Feb 14. Epub 2019 Feb 14.

Department of Paediatrics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Background And Objective: Asthma is a global problem and complex disease suited for metabolomic profiling. This study explored the candidate biomarkers specific to paediatric asthma and provided insights into asthmatic pathophysiology.

Methods: Children (aged 6-11 years) meeting the criteria for healthy control (n = 29), uncontrolled asthma (n = 37) or controlled asthma (n = 43) were enrolled. Read More

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http://dx.doi.org/10.1111/resp.13479DOI Listing
February 2019

Reduced mortality from lower respiratory tract disease in adult diabetic patients treated with metformin.

Respirology 2019 Feb 13. Epub 2019 Feb 13.

Division of Pulmonary Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Background And Objective: Chronic lower respiratory diseases (CLRD) increase the risk of type 2 diabetes, which in turn may worsen lung function. Metformin, a common antidiabetic with anti-inflammatory and antioxidant properties, may improve respiratory outcomes. Therefore, we examined the association of metformin use with the risk of mortality from CLRD. Read More

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http://dx.doi.org/10.1111/resp.13486DOI Listing
February 2019

Time to FOCUS on oral corticosteroid stewardship in asthma management.

Respirology 2019 Feb 13. Epub 2019 Feb 13.

Respiratory Medicine, Royal Brompton Hospital, London, UK.

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http://dx.doi.org/10.1111/resp.13494DOI Listing
February 2019

Microparticles in systemic sclerosis: Potential pro-inflammatory mediators and pulmonary hypertension biomarkers.

Respirology 2019 Feb 12. Epub 2019 Feb 12.

Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

Background And Objective: Endothelial microparticles (EMP) are submicron vesicles released from endothelial cells. We aimed to determine the utility of EMP as biomarkers of pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) patients and the pathogenic role of microparticles (MP) in vascular inflammation.

Methods: Levels of EMP (CD144+, CD31+, CD62E+ and CD143+) were compared between three groups (10 SSc patients with PAH, 10 SSc patients without pulmonary hypertension (no-PH) and 10 healthy age- and sex-matched controls). Read More

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http://dx.doi.org/10.1111/resp.13500DOI Listing
February 2019
2 Reads

Ambulatory oxygen delivery-an answer: But what is the question?

Respirology 2019 Feb 12. Epub 2019 Feb 12.

Department of Respiratory and Sleep Medicine, Austin Hospital, Institute for Breathing and Sleep, University of Melbourne, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1111/resp.13505DOI Listing
February 2019
1 Read

Molecular breath analysis for IPF: Can we make a few breaths count?

Respirology 2019 Feb 12. Epub 2019 Feb 12.

Firestone Institute for Respiratory Health, Research Institute at St Joseph's Healthcare, Department of Medicine, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1111/resp.13503DOI Listing
February 2019
1 Read

Contemporary Concise Review 2018: Bronchiectasis.

Respirology 2019 Feb 11. Epub 2019 Feb 11.

School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.

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http://dx.doi.org/10.1111/resp.13502DOI Listing
February 2019
1 Read

Technological advances in home non-invasive ventilation monitoring: Reliability of data and effect on patient outcomes.

Respirology 2019 Feb 10. Epub 2019 Feb 10.

Normandie Univ, UNIRouen, EA3830-GRHV, Institute for Research and Innovation in Biomedicine (IRIB), Rouen, France.

Home non-invasive mechanical ventilation (NIV) has become a well-established treatment for patients with chronic hypercapnic respiratory failure. NIV monitoring has been developed to evaluate the effectiveness of mechanical ventilation on patient outcomes, with built-in systems providing data on compliance, leaks and respiratory parameters. Although these data seem intuitively useful, two main concerns have been raised in the literature: (i) are they reliable and (ii) to what extent does their use improve patient outcomes. Read More

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http://dx.doi.org/10.1111/resp.13497DOI Listing
February 2019
1 Read

Severe acute respiratory syndrome and other emerging severe respiratory viral infections.

Respirology 2019 Feb 7. Epub 2019 Feb 7.

School of Public Health, University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1111/resp.13501DOI Listing
February 2019
1 Read

Clinical usefulness of routine AFB culture and MTB PCR of EBUS-TBNA needle rinse fluid.

Respirology 2019 Feb 7. Epub 2019 Feb 7.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Background And Objective: We evaluated the usefulness of acid-fast bacilli (AFB) culture and Mycobacterium tuberculosis (MTB) polymerase chain reaction (PCR) of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) needle rinse fluid for diagnosing tuberculous lymphadenitis.

Methods: EBUS-TBNA needle rinse fluid was routinely used for AFB culture and MTB PCR. The patients were categorized according to the pre-procedural diagnosis (Group A, suspected/histology-confirmed lung cancer; Group B, extrapulmonary malignancy; and Group C, other benign diseases). Read More

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http://dx.doi.org/10.1111/resp.13488DOI Listing
February 2019

Bronchiolitis obliterans syndrome 'endotypes' in haematopoietic stem cell transplantation.

Respirology 2019 Feb 7. Epub 2019 Feb 7.

Queensland Lung Transplant Program, The Prince Charles Hospital, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1111/resp.13498DOI Listing
February 2019
1 Read

Home mechanical ventilation for chronic obstructive pulmonary disease: What next after the HOT-HMV trial?

Respirology 2019 Feb 7. Epub 2019 Feb 7.

Lane Fox Respiratory Service, Guy's and St Thomas' NHS Foundation Trust, London, UK.

The benefits of acute non-invasive ventilation to treat acidotic exacerbations of chronic obstructive pulmonary disease (COPD) are well-established. Until recently, the evidence for home mechanical ventilation (HMV) to treat patients with stable COPD had been lacking. This has subsequently been addressed by the application of higher levels of pressure support combined with targeted management of chronic respiratory failure, which demonstrated a reduction in all-cause mortality. Read More

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http://dx.doi.org/10.1111/resp.13484DOI Listing
February 2019
2 Reads

Bidirectional association between tuberculosis and sarcoidosis.

Respirology 2019 Feb 5. Epub 2019 Feb 5.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background And Objective: Tuberculosis (TB) and sarcoidosis are both granulomatous diseases with potential interassociations. However, much uncertainty remains; thus, the present study aimed to clarify the association between these diseases.

Methods: We established two cohorts in this retrospective longitudinal cohort study using data obtained from the Taiwan National Health Insurance Database from 2000 to 2015. Read More

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http://dx.doi.org/10.1111/resp.13482DOI Listing
February 2019
2 Reads

Idiopathic chronic productive cough and response to open-label macrolide therapy: An observational study.

Respirology 2019 Feb 5. Epub 2019 Feb 5.

The Asthma Centre, Nottingham NIHR Biomedical Research Centre, University of Nottingham, Nottingham City Hospital, Nottingham, UK.

Background And Objective: Adult patients with chronic productive cough of unknown cause are commonly seen in respiratory clinics. We have previously described a subgroup of these patients who have a short-lived response to standard antibiotic treatment but a prolonged response to 3 months of low-dose azithromycin therapy.

Methods: This observational study describes the physiological, radiological and pathological features of this patient cohort along with their response to a 12-week open-label trial of 250 mg azithromycin thrice weekly. Read More

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http://dx.doi.org/10.1111/resp.13483DOI Listing
February 2019
1 Read

Infection risks for patients from healthcare workers with cystic fibrosis - Reply.

Respirology 2019 Feb 4. Epub 2019 Feb 4.

Department of Infectious Diseases, Monash Health, Clayton, VIC, Australia.

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http://dx.doi.org/10.1111/resp.13489DOI Listing
February 2019

Infection risks for patients from healthcare workers with cystic fibrosis.

Respirology 2019 Feb 4. Epub 2019 Feb 4.

Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1111/resp.13487DOI Listing
February 2019

BMI but not central obesity predisposes to airway closure during bronchoconstriction.

Respirology 2019 Jan 29. Epub 2019 Jan 29.

Division of Pulmonary and Critical Care Medicine, Vermont Lung Center, University of Vermont Larner College of Medicine, Burlington, VT, USA.

Background And Objective: Obesity produces restrictive effects on lung function. We previously reported that obese patients with asthma exhibit a propensity towards small airway closure during methacholine challenge which improved with weight loss. We hypothesized that increased abdominal adiposity, a key contributor to the restrictive effects of obesity on the lung, mediates this response. Read More

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http://dx.doi.org/10.1111/resp.13478DOI Listing
January 2019
1 Read

Severe asthma treated by bronchial thermoplasty: A success not due to the small airways?

Respirology 2019 Jan 29. Epub 2019 Jan 29.

Université de Montpellier, PhyMedExp, INSERM, CNRS, CHU de Montpellier, Department of Respiratory Diseases, Montpellier, France.

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http://dx.doi.org/10.1111/resp.13481DOI Listing
January 2019

Development and validation of the COugh Assessment Test (COAT).

Respirology 2019 Jan 25. Epub 2019 Jan 25.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea.

Background And Objective: A cough-specific quality-of-life questionnaire is recommended to assess the impact of cough; however, a simple instrument to quantify cough is required for everyday clinical practice. This study was aimed to develop a short patient-completed questionnaire (COugh Assessment Test, COAT).

Methods: The COAT was developed and validated by comparison with the Korean version of Leicester Cough Questionnaire (K-LCQ) and cough numeric rating scale (NRS, 0-10, 11-point scale) for chronic cough patients. Read More

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http://dx.doi.org/10.1111/resp.13462DOI Listing
January 2019
2 Reads

Molecular breath analysis supports altered amino acid metabolism in idiopathic pulmonary fibrosis.

Respirology 2019 Jan 25. Epub 2019 Jan 25.

Department of Pulmonology, University Hospital of Zurich, Zurich, Switzerland.

Background And Objective: Diagnosis of idiopathic pulmonary fibrosis (IPF) is complex and its pathogenesis is poorly understood. Recent findings indicate elevated levels of proline and other amino acids in lung tissue of IPF patients which may also be of diagnostic value. Following these findings, we hypothesized that such altered metabolic profiles would be mirrored in exhaled breath and could therefore be captured non-invasively in real time. Read More

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http://doi.wiley.com/10.1111/resp.13465
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http://dx.doi.org/10.1111/resp.13465DOI Listing
January 2019
7 Reads

Letter from the UK (if we still exist after recent events!): Air pollution: The public health challenge of our time.

Respirology 2019 Jan 25. Epub 2019 Jan 25.

Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

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http://doi.wiley.com/10.1111/resp.13475
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http://dx.doi.org/10.1111/resp.13475DOI Listing
January 2019
3 Reads

The patients have spoken; now it is time for us to listen and move the needle forward.

Respirology 2019 Jan 25. Epub 2019 Jan 25.

University of Pittsburgh PACCM, Dorothy P. & Richard P. Simmons Center for Interstitial Lung Disease at UPMC, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1111/resp.13476DOI Listing
January 2019

Letter from South Africa.

Authors:
Charles Feldman

Respirology 2019 Jan 24. Epub 2019 Jan 24.

Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

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http://dx.doi.org/10.1111/resp.13477DOI Listing
January 2019

Safety and diagnostic performance of pulmonologists performing electromagnetic guided percutaneous lung biopsy (SPiNperc).

Respirology 2019 Jan 24. Epub 2019 Jan 24.

Section of Interventional Pulmonology, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background And Objective: Percutaneous lung biopsy for diagnostic sampling of peripheral lung nodules has been widely performed by interventional radiologists under computed tomography (CT) guidance. New technology allows pulmonologists to perform percutaneous lung biopsies using electromagnetic (EM) guided technology. With the adoption of this new technique, the safety, feasibility and diagnostic yield need to be explored. Read More

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http://doi.wiley.com/10.1111/resp.13471
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http://dx.doi.org/10.1111/resp.13471DOI Listing
January 2019
2 Reads
3.495 Impact Factor

Pharyngeal distensibility during expiration is an independent predictor of the severity of obstructive sleep apnoea.

Respirology 2019 Jan 24. Epub 2019 Jan 24.

Sleep Center, Department of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Background And Objective: Pharyngeal distensibility and collapsibility reflect the passive properties of tissue in the airway, are an indicator of the ease with which an airway can be deformed and are related to the severity of obstructive sleep apnoea (OSA). During normal tidal respiration, the collapsibility of the pharynx during expiration is passive without confounding by neuromuscular activation that occurs during inspiration. We evaluated the distensibility and collapsibility of the upper airway in subjects with OSA during wakefulness using sophisticated dynamic computed tomography (CT) imaging. Read More

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http://dx.doi.org/10.1111/resp.13474DOI Listing
January 2019

Rapid versus gradual lung function decline in bronchiolitis obliterans syndrome after haematopoietic stem cell transplantation is associated with survival outcome.

Respirology 2019 Jan 20. Epub 2019 Jan 20.

Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong.

Background And Objective: Bronchiolitis obliterans syndrome (BOS) after haematopoietic stem cell transplantation (HSCT) presents with lung function decline. The pattern of lung function decline after BOS diagnosis could impact prognostication of BOS as a complication after HSCT. The aim of this study was to assess the impact of lung function decline on overall survival (OS) in BOS subjects. Read More

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http://doi.wiley.com/10.1111/resp.13472
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http://dx.doi.org/10.1111/resp.13472DOI Listing
January 2019
4 Reads

Age-dependent hypoxia-induced PD-L1 upregulation in patients with obstructive sleep apnoea.

Respirology 2019 Jan 17. Epub 2019 Jan 17.

Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Madrid, Spain.

Background And Objective: In obstructive sleep apnoea (OSA), intermittent hypoxia (IH) compromises immune surveillance through the upregulation of the programmed cell death-1 (PD-1) receptor and its ligand (PD-L1). Because the risk of OSA-related cancer depends on age, we assessed PD-L1/PD-1 expression in middle-aged and older patients with OSA as well as in a murine model.

Methods: PD-L1 expression was studied in 41 patients with severe OSA and 40 healthy volunteers (HV), divided into two groups (≤55 and >55 years of age). Read More

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http://doi.wiley.com/10.1111/resp.13470
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http://dx.doi.org/10.1111/resp.13470DOI Listing
January 2019
3 Reads

Angiopoietin-2 as a predictor of acute kidney injury in critically ill patients and association with ARDS.

Respirology 2019 Jan 17. Epub 2019 Jan 17.

Medical Sciences Postgraduate Program, Universidade de Fortaleza - UNIFOR, Fortaleza, Brazil.

Background And Objective: Angiopoietin-2 (AGPT2) has been proposed as a key mediator of organ dysfunction, mainly in acute respiratory distress syndrome (ARDS). It has also been associated with acute kidney injury (AKI). We aimed to investigate the role of AGPT2 in patients with and without ARDS. Read More

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http://doi.wiley.com/10.1111/resp.13464
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http://dx.doi.org/10.1111/resp.13464DOI Listing
January 2019
7 Reads

Airway clearance, mucoactive therapies and pulmonary rehabilitation in bronchiectasis.

Respirology 2019 Jan 16. Epub 2019 Jan 16.

The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, UK.

This paper aims to provide physiological rationale for airway clearance, mucoactive therapy and pulmonary rehabilitation (PR) (or exercise interventions) in bronchiectasis. There is increasing emphasis on the role of airway clearance techniques (ACT) in the management of bronchiectasis. No single ACT has currently shown superior effect over another. Read More

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http://dx.doi.org/10.1111/resp.13459DOI Listing
January 2019
5 Reads

Nurturing Respirology.

Respirology 2019 Feb;24(2):92

Respiratory and Sleep Medicine, Royal Adelaide Hospital and University of Adelaide, Adelaide, SA, Australia.

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http://dx.doi.org/10.1111/resp.13466DOI Listing
February 2019

Somatic mutations and immune checkpoint biomarkers.

Respirology 2019 Jan 12. Epub 2019 Jan 12.

Department of Haematology-Oncology, National University Hospital, Singapore.

The development of molecular testing for identifying somatic mutations and immune checkpoint biomarkers has directed treatment towards personalized medicine for patients with non-small cell lung cancer. The choice of molecular testing in a clinical setting is influenced by cost, expertise in the technology, instrumentation setup and sample type availability. The molecular techniques described in this review include immunohistochemistry (IHC), fluorescent in situ hybridization, direct sequencing, real-time polymerase chain reaction (PCR), denaturing high-performance liquid chromatography, matrix-assisted laser desorption/ionization time of flight mass spectrometry and next-generation sequencing (NGS). Read More

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http://doi.wiley.com/10.1111/resp.13463
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http://dx.doi.org/10.1111/resp.13463DOI Listing
January 2019
5 Reads

Benefits of non-invasive ventilation in acute hypercapnic respiratory failure.

Respirology 2019 Jan 12. Epub 2019 Jan 12.

Respiratory and Critical Care Unit, University Hospital St Orsola-Malpighi, Bologna, Italy.

Non-invasive ventilation (NIV) with bilevel positive airway pressure is a non-invasive technique, which refers to the provision of ventilatory support through the patient's upper airway using a mask or similar device. This technique is successful in correcting hypoventilation. It has become widely accepted as the standard treatment for patients with hypercapnic respiratory failure (HRF). Read More

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http://dx.doi.org/10.1111/resp.13469DOI Listing
January 2019
3 Reads

Treating moderate-severe obstructive sleep apnoea for cardiovascular health: Is what stake the stakeholder holds important?

Respirology 2019 Jan 10. Epub 2019 Jan 10.

CIRUS, Sleep and Circadian Group, Woolcock Institute, University of Sydney, Sydney, NSW, Australia.

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http://doi.wiley.com/10.1111/resp.13467
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http://dx.doi.org/10.1111/resp.13467DOI Listing
January 2019
4 Reads

CPAP treatment for asthma? A question worth pursuing further.

Respirology 2019 Jan 10. Epub 2019 Jan 10.

Monash University, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1111/resp.13473DOI Listing
January 2019

Is there a common pattern in physical activity levels comparing diverse chronic airway diseases?

Respirology 2019 Jan 10. Epub 2019 Jan 10.

Respiratory Clinic Institute, Hospital Clinic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

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http://dx.doi.org/10.1111/resp.13468DOI Listing
January 2019

Volume-targeted pressure support and automatic EPAP for chronic hypoventilation syndromes: An advance in-home ventilation or just more noise?

Authors:
Nigel McArdle

Respirology 2018 Dec 21. Epub 2018 Dec 21.

Department of Pulmonary Physiology and Sleep Medicine, Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, WA, Australia.

Early in the history of non-invasive ventilation (NIV) for disorders of hypoventilation, treatment was provided by volume-limited (VL) devices. Currently, NIV is commonly provided by pressure-limited (PL) devices because of greater portability, lower cost and studies showing increased patient comfort. There are now volume-targeted (VT) devices, which aim to combine the advantages of more stable ventilation associated with VL and greater comfort of PL mode. Read More

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http://doi.wiley.com/10.1111/resp.13458
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http://dx.doi.org/10.1111/resp.13458DOI Listing
December 2018
5 Reads

Pulmonary fibrosis: Genetic analysis of telomere-related genes, telomere length measurement-or both?

Respirology 2019 Feb 17;24(2):97-98. Epub 2018 Dec 17.

Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK.

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http://dx.doi.org/10.1111/resp.13456DOI Listing
February 2019
1 Read

Comparison of continuous flow versus demand oxygen delivery systems in patients with COPD: A systematic review and meta-analysis.

Respirology 2018 Dec 17. Epub 2018 Dec 17.

Institute for Pulmonary Rehabilitation Research, Schoen Klinik Berchtesgadener Land, Schoenau am Koenigssee, Germany.

Demand oxygen delivery systems (DODS) enable prolongation of liquid oxygen cylinder life compared to continuous oxygen flow (CONT) use. Evidence is lacking, however, regarding their efficacy. This study investigated the literature comparing liquid-based CONT to DODS in patients with chronic obstructive pulmonary disease (COPD). Read More

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http://dx.doi.org/10.1111/resp.13457DOI Listing
December 2018
2 Reads

Pressuring stable patients with hypercapnic COPD to exercise.

Respirology 2018 Dec 13. Epub 2018 Dec 13.

Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia.

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http://dx.doi.org/10.1111/resp.13454DOI Listing
December 2018

Cystic fibrosis vigilance in Arab countries: The role of genetic epidemiology.

Authors:
Michael Pallin

Respirology 2019 Feb 13;24(2):93-94. Epub 2018 Dec 13.

Monash Lung and Sleep, Monash Medical Centre, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1111/resp.13461DOI Listing
February 2019

When is a confounder not a confounder?

Authors:
Robert J Hancox

Respirology 2019 Feb 13;24(2):105-106. Epub 2018 Dec 13.

Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1111/resp.13460DOI Listing
February 2019

CORRIGENDUM.

Authors:

Respirology 2019 Jan 30;24(1):85. Epub 2018 Nov 30.

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http://dx.doi.org/10.1111/resp.13448DOI Listing
January 2019

TRPA1: A potential target for cold-induced airway disease?

Respirology 2018 Dec 13. Epub 2018 Dec 13.

Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, Newcastle, NSW, Australia.

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http://dx.doi.org/10.1111/resp.13453DOI Listing
December 2018

Empyema: A debilitating condition that warrants further research.

Authors:
Pyng Lee

Respirology 2019 Feb 11;24(2):101-102. Epub 2018 Dec 11.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1111/resp.13455DOI Listing
February 2019
1 Read

Management of adverse reactions to high-dose moxifloxacin used in multidrug-resistant tuberculosis treatment programmes.

Respirology 2018 Dec 6. Epub 2018 Dec 6.

Tuberculosis and Chest Service, Centre for Health Protection, Department of Health, Hong Kong, China.

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http://dx.doi.org/10.1111/resp.13452DOI Listing
December 2018
2 Reads

Non-invasive ventilation: Inspiring clinical practice.

Respirology 2018 Dec 3. Epub 2018 Dec 3.

Division of Respiratory Medicine, Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong, SAR, People's Republic of China.

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http://dx.doi.org/10.1111/resp.13449DOI Listing
December 2018
1 Read

High-intensity non-invasive ventilation in stable hypercapnic COPD: Evidence of efficacy and practical advice.

Respirology 2018 Nov 30. Epub 2018 Nov 30.

Department of Pulmonary Diseases/Home Mechanical Ventilation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Patients with end-stage chronic obstructive pulmonary disease (COPD) frequently develop chronic hypercapnic respiratory failure (CHRF), with disabling symptoms and poor survival. The use of long-term nocturnal non-invasive ventilation (NIV) to treat CHRF in COPD has long been subject of debate due to conflicting evidence. However, since the introduction of high-intensity NIV (HI-NIV) in COPD, physiological and clinical benefits have been shown. Read More

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http://dx.doi.org/10.1111/resp.13450DOI Listing
November 2018
1 Read

Paediatric and adult bronchiectasis: Monitoring, cross-infection, role of multidisciplinary teams and self-management plans.

Respirology 2019 Feb 30;24(2):115-126. Epub 2018 Nov 30.

Child Health Division, Menzies School of Health Research, Darwin, NT, Australia.

Bronchiectasis is a chronic lung disease associated with structurally abnormal bronchi, clinically manifested by a persistent wet/productive cough, airway infections and recurrent exacerbations. Early identification and treatment of acute exacerbations is an integral part of monitoring and annual review, in both adults and children, to minimize further damage due to infection and inflammation. Common modalities used to monitor disease progression include clinical signs and symptoms, frequency of exacerbations and/or number of hospital admissions, lung function (forced expiratory volume in 1 s (FEV )% predicted), imaging (radiological severity of disease) and sputum microbiology (chronic infection with Pseudomonas aeruginosa). Read More

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http://dx.doi.org/10.1111/resp.13451DOI Listing
February 2019
9 Reads

Paediatric and adult bronchiectasis: Vaccination in prevention and management.

Respirology 2019 Feb 26;24(2):107-114. Epub 2018 Nov 26.

School of Medicine, Griffith University, Gold Coast, QLD, Australia.

Bronchiectasis has received increased attention recently, including an emphasis on preventing infective exacerbations that are associated with disease progression and lung function decline. While there are several bacteria and viruses associated with bronchiectasis, licensed vaccines are only currently available for Streptococcus pneumoniae, Haemophilus influenzae (H. influenzae protein D as a conjugate in a pneumococcal vaccine), Mycobacterium tuberculosis, Bordetella pertussis and influenza virus. Read More

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http://doi.wiley.com/10.1111/resp.13446
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http://dx.doi.org/10.1111/resp.13446DOI Listing
February 2019
8 Reads

Radiofrequency spectral analysis of EBUS for peripheral pulmonary lesions.

Respirology 2018 Nov 23. Epub 2018 Nov 23.

Division of Respiratory Diseases, Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki, Japan.

Background And Objective: We previously reported that histogram-based quantitative evaluation for endobronchial ultrasonography (EBUS) B-mode images could differentiate between benign and malignant lesions. However, these images were generated from reconstructed raw radiofrequency (RF) signals and had some limitations. Currently, there are no reports on raw RF signal data to quantitatively differentiate ultrasound information for peripheral pulmonary lesions. Read More

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http://dx.doi.org/10.1111/resp.13443DOI Listing
November 2018
9 Reads