3,368 results match your criteria Respirology[Journal]


Management of adverse reactions to high-dose moxifloxacin used in multidrug-resistant tuberculosis treatment programmes.

Respirology 2018 Dec 6. Epub 2018 Dec 6.

Tuberculosis and Chest Service, Centre for Health Protection, Department of Health, Hong Kong, China.

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December 2018

Non-invasive ventilation: Inspiring clinical practice.

Respirology 2018 Dec 3. Epub 2018 Dec 3.

Division of Respiratory Medicine, Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong, SAR, People's Republic of China.

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December 2018

High-intensity non-invasive ventilation in stable hypercapnic COPD: Evidence of efficacy and practical advice.

Respirology 2018 Nov 30. Epub 2018 Nov 30.

Department of Pulmonary Diseases/Home Mechanical Ventilation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Patients with end-stage chronic obstructive pulmonary disease (COPD) frequently develop chronic hypercapnic respiratory failure (CHRF), with disabling symptoms and poor survival. The use of long-term nocturnal non-invasive ventilation (NIV) to treat CHRF in COPD has long been subject of debate due to conflicting evidence. However, since the introduction of high-intensity NIV (HI-NIV) in COPD, physiological and clinical benefits have been shown. Read More

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November 2018

Paediatric and adult bronchiectasis: Monitoring, cross-infection, role of multidisciplinary teams and self-management plans.

Respirology 2018 Nov 30. Epub 2018 Nov 30.

Child Health Division, Menzies School of Health Research, Darwin, NT, Australia.

Bronchiectasis is a chronic lung disease associated with structurally abnormal bronchi, clinically manifested by a persistent wet/productive cough, airway infections and recurrent exacerbations. Early identification and treatment of acute exacerbations is an integral part of monitoring and annual review, in both adults and children, to minimize further damage due to infection and inflammation. Common modalities used to monitor disease progression include clinical signs and symptoms, frequency of exacerbations and/or number of hospital admissions, lung function (forced expiratory volume in 1 s (FEV )% predicted), imaging (radiological severity of disease) and sputum microbiology (chronic infection with Pseudomonas aeruginosa). Read More

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November 2018
3 Reads

Paediatric and adult bronchiectasis: Vaccination in prevention and management.

Respirology 2018 Nov 26. Epub 2018 Nov 26.

School of Medicine, Griffith University, Gold Coast, QLD, Australia.

Bronchiectasis has received increased attention recently, including an emphasis on preventing infective exacerbations that are associated with disease progression and lung function decline. While there are several bacteria and viruses associated with bronchiectasis, licensed vaccines are only currently available for Streptococcus pneumoniae, Haemophilus influenzae (H. influenzae protein D as a conjugate in a pneumococcal vaccine), Mycobacterium tuberculosis, Bordetella pertussis and influenza virus. Read More

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November 2018
5 Reads

Radiofrequency spectral analysis of EBUS for peripheral pulmonary lesions.

Respirology 2018 Nov 23. Epub 2018 Nov 23.

Division of Respiratory Diseases, Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki, Japan.

Background And Objective: We previously reported that histogram-based quantitative evaluation for endobronchial ultrasonography (EBUS) B-mode images could differentiate between benign and malignant lesions. However, these images were generated from reconstructed raw radiofrequency (RF) signals and had some limitations. Currently, there are no reports on raw RF signal data to quantitatively differentiate ultrasound information for peripheral pulmonary lesions. Read More

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November 2018
5 Reads

Non-invasive ventilation: Essential requirements and clinical skills for successful practice.

Authors:
Mark W Elliott

Respirology 2018 Nov 23. Epub 2018 Nov 23.

Department of Respiratory Medicine, St James's University Hospital, Leeds, UK.

Audits and case reviews of the acute delivery of non-invasive ventilation (NIV) have shown that the results achieved in real life often fall short of those achieved in research trials. Factors include inappropriate selection of patients for NIV and failure to apply NIV correctly. This highlights the need for proper training of all involved individuals. Read More

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November 2018
1 Read

Pulmonary rehabilitation for chronic obstructive pulmonary disease: Has it peaked?

Authors:
Anne E Holland

Respirology 2018 Nov 22. Epub 2018 Nov 22.

Discipline of Physiotherapy, La Trobe University, Melbourne, VIC, Australia.

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November 2018

Acute respiratory distress syndrome and the promise of driving pressure.

Respirology 2018 Nov 22. Epub 2018 Nov 22.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Diego, San Diego, CA, USA.

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November 2018
5 Reads

Remarkable progress in cystic fibrosis-But why?

Respirology 2018 Nov 22. Epub 2018 Nov 22.

Alfred Health Cystic Fibrosis Service, Monash University, Melbourne, VIC, Australia.

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November 2018

Effect of CPAP on airway reactivity and airway inflammation in children with moderate-severe asthma.

Respirology 2018 Nov 16. Epub 2018 Nov 16.

Department of Pediatrics, Division of Pulmonology, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA.

Background And Objective: Asthma is characterized by airway hyperreactivity and airway inflammation. We previously demonstrated that adults with mild well-controlled asthma exhibited a marked decrease in airway reactivity (PC20 increased >2-fold) after using nocturnal continuous positive airway pressure (CPAP) for 1 week. If CPAP produces a similar suppression of airway reactivity in children with moderate-severe asthma, who require chronic use of corticosteroids, then this non-pharmacological therapy might provide a beneficial alternative or supplemental therapy in these subjects. Read More

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November 2018
5 Reads

Repeated exposure to temperature variation exacerbates airway inflammation through TRPA1 in a mouse model of asthma.

Respirology 2018 Nov 15. Epub 2018 Nov 15.

Joint International Research Laboratory of Green Buildings and Built Environments (Ministry of Education), Chongqing University, Chongqing, China.

Background And Objective: Studies from epidemiology suggest that ambient temperature is one of the underlying triggers and potential causes of asthma. The aim of this study was to examine the impact and the molecular mechanism of temperature-invoked airway inflammation using an experimental model of asthma in BALB/c mice.

Methods: Mice were exposed to different temperature conditions (steady 26°C, 26°C/18°C cycle, 26°C/10°C cycle) and received sensitization and challenge of ovalbumin (OVA) during a 21-day period. Read More

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November 2018
5 Reads

Lumpers versus splitters: What to do with suspected idiopathic pulmonary fibrosis?

Respirology 2018 Nov 15. Epub 2018 Nov 15.

Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

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November 2018
2 Reads

Respiratory muscle weakness increases dead-space ventilation ratio aggravating ventilation-perfusion mismatch during exercise in patients with chronic heart failure.

Respirology 2018 Nov 14. Epub 2018 Nov 14.

Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.

Background And Objective: Respiratory muscle weakness causes fatigue in these muscles during exercise and thereby increases dead-space ventilation ratio with decreased tidal volume. However, it remains unclear whether respiratory muscle weakness aggravates ventilation-perfusion mismatch through the increased dead-space ventilation ratio. In ventilation-perfusion mismatch during exercise, minute ventilation versus carbon dioxide production (VE/VCO ) slope > 34 is an indicator of poor prognosis in patients with chronic heart failure (CHF). Read More

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November 2018
1 Read

Genetic risk factors for the development of pulmonary disease identified by genome-wide association.

Respirology 2018 Nov 13. Epub 2018 Nov 13.

Division of Respiratory Medicine, NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.

Chronic respiratory diseases are a major cause of morbidity and mortality. Asthma and chronic obstructive pulmonary disease (COPD) combined affect over 500 million people worldwide. While environmental factors are important in disease progression, asthma and COPD have long been known to be heritable with genetic components playing an important role in the risk of developing disease. Read More

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November 2018
4 Reads

Measuring the effects of bronchial thermoplasty using oscillometry.

Respirology 2018 Nov 12. Epub 2018 Nov 12.

Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.

Background And Objective: Bronchial thermoplasty (BT) has been consistently shown to reduce symptoms, exacerbations and the need for reliever medication in patients with severe asthma. Paradoxically, no consistent improvement in spirometry has been demonstrated. It has been suggested that this is due to a reduction in peripheral resistance in small airways, not captured by spirometry. Read More

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November 2018
2 Reads

Spectrum of mutations of cystic fibrosis in the 22 Arab countries: A systematic review.

Respirology 2018 Nov 12. Epub 2018 Nov 12.

Biomedical Science Department, College of Health Sciences, Qatar University, Doha, Qatar.

Cystic fibrosis (CF) is an autosomal recessive genetic disease caused by mutations in the CFTR gene, with various clinical manifestations that affect pulmonary, digestive, exocrine and male reproductive functions as well as the bones and kidneys. This study aimed to reveal the spectrum of CFTR gene mutations in Arab CF patients and their corresponding clinical phenotypes among the 22 Arab countries. We searched four literature databases (PubMed, Science Direct, Web of Science and Scopus) from their times of inception to January 2018. Read More

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November 2018
2 Reads

In search of a good fit: CPAP therapy mask selection for obstructive sleep apnoea.

Respirology 2018 Nov 8. Epub 2018 Nov 8.

School of Medicine, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

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November 2018
1 Read

Respiratory adjuncts to NIV in neuromuscular disease.

Respirology 2018 Nov 8. Epub 2018 Nov 8.

Department of Respiratory and Sleep Medicine, Austin Health, Melbourne, VIC, Australia.

Muscle weakness is an intrinsic feature of neuromuscular diseases (NMD). When the respiratory muscles are involved, the ability to take a deep breath is compromised, leading to reduced lung volumes and a restrictive ventilatory impairment. Inspiratory, expiratory and bulbar muscle weakness can also impair cough, which may impede secretion clearance. Read More

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November 2018
1 Read

Non-invasive ventilation or high-flow oxygen therapy: When to choose one over the other?

Respirology 2018 Nov 8. Epub 2018 Nov 8.

Médecine Intensive Réanimation, CHU de Poitiers, Poitiers, France.

It has been found that high-flow oxygen therapy (HFOT) can reduce mortality of patients admitted to intensive care unit (ICU) for de novo acute respiratory failure (ARF) as compared to non-invasive ventilation (NIV). HFOT might therefore be considered as a first-line strategy of oxygenation in these patients. The beneficial effects of HFOT may be explained by its good tolerance and by physiological characteristics including delivery of high FiO , positive end expiratory pressure (PEEP) effect and continuous dead space washout contributing to decreased work of breathing. Read More

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November 2018
13 Reads

Pulmonary arterial hypertension: In Asia, as elsewhere, still a lethal disease despite modern treatment.

Authors:
Paul N Reynolds

Respirology 2018 Nov 8. Epub 2018 Nov 8.

Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia.

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November 2018

Physical activity associates with disease characteristics of severe asthma, bronchiectasis and COPD.

Respirology 2018 Nov 1. Epub 2018 Nov 1.

National Health and Medical Research Council Centre of Excellence in Severe Asthma, Newcastle, NSW, Australia.

Background And Objective: Physical activity (PA) in obstructive airway diseases (OAD) is likely to be impaired but this has not been extensively studied outside of chronic obstructive pulmonary disease (COPD). We describe PA levels in severe asthma and bronchiectasis compared to moderate-severe COPD and to controls, and tested the cross-sectional associations of PA (steps/day) with shared disease characteristics in the OAD group.

Methods: Adults with OAD (severe asthma = 62, COPD = 67, bronchiectasis = 60) and controls (n = 63) underwent a multidimensional assessment, including device-measured PA levels. Read More

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November 2018
5 Reads

Applying new tools to control tuberculosis.

Respirology 2018 Dec 19;23(12):1114-1116. Epub 2018 Oct 19.

Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

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December 2018
2 Reads

Clinical utility of pulmonary function and blood biomarker measurements.

Authors:
Ross Vlahos

Respirology 2018 Oct 19. Epub 2018 Oct 19.

School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia.

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October 2018

A letter from 'O Canada'.

Respirology 2018 Oct 17. Epub 2018 Oct 17.

UBC Centre for Heart Lung Innovation (HLI), St. Paul's Hospital, Vancouver, BC, Canada.

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October 2018
4 Reads

Implications of the diagnostic criteria of idiopathic pulmonary fibrosis in clinical practice: Analysis from the Australian Idiopathic Pulmonary Fibrosis Registry.

Respirology 2018 Oct 17. Epub 2018 Oct 17.

Department of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia.

Background And Objective: Current guidelines for the diagnosis of idiopathic pulmonary fibrosis (IPF) provide specific criteria for diagnosis in the setting of multidisciplinary discussion (MDD). We evaluate the utility and reproducibility of these diagnostic guidelines, using clinical data from the Australian IPF Registry.

Methods: All patients enrolled in the registry undergo a diagnostic review whereby international IPF guidelines are applied via a registry MDD. Read More

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October 2018
9 Reads

Towards a refined definition of combined pulmonary fibrosis and emphysema.

Respirology 2018 Oct 15. Epub 2018 Oct 15.

Interstitial Lung Disease Program, National Jewish Health, Denver, CO, USA.

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October 2018
2 Reads

Predicting response to bronchial thermoplasty in patients with severe uncontrolled asthma: An elusive goal.

Respirology 2018 Oct 15. Epub 2018 Oct 15.

Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO, USA.

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October 2018

Predictive factors and prognostic effect of telomere shortening in pulmonary fibrosis.

Respirology 2018 Oct 15. Epub 2018 Oct 15.

Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.

Background And Objective: The abnormal shortening of telomeres is a mechanism linking ageing to idiopathic pulmonary fibrosis (IPF) that could be useful in the clinical setting. The objective of this study was to identify the IPF patients with higher risk for telomere shortening and to investigate the outcome implications.

Methods: Consecutive Spanish patients were included at diagnosis and followed up for 3 years. Read More

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October 2018
9 Reads

Red blood cell transfusion in acute pulmonary embolism - Reply.

Respirology 2018 Nov 19;23(11):1076-1077. Epub 2018 Sep 19.

Department of Cardiology, Concord Repatriation General Hospital, Sydney, NSW, Australia.

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November 2018
3.500 Impact Factor

Double combination inhalers in COPD: How to get your head around this data.

Authors:
Dave Singh

Respirology 2018 Dec 12;23(12):1088-1089. Epub 2018 Oct 12.

Medicines Evaluation Unit, The Langley Building, University of Manchester, Manchester University Foundation Trust NHS Hospital, Manchester, UK.

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December 2018
2 Reads

Targeting reactive oxygen species for respiratory infection: Fact or fancy?

Respirology 2018 Oct 8. Epub 2018 Oct 8.

Oxidant and Inflammation Biology Group, School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.

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October 2018

Modelling COPD co-morbidities in preclinical models.

Respirology 2018 Dec 4;23(12):1094-1095. Epub 2018 Oct 4.

School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia.

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December 2018
1 Read

TGF-β: Master regulator of inflammation and fibrosis.

Respirology 2018 Dec 4;23(12):1096-1097. Epub 2018 Oct 4.

Pulmonary, Critical Care and Sleep Medicine, Yale University, New Haven, CT, USA.

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December 2018
1 Read

A consensus opinion amongst stakeholders as to benefits of obstructive sleep apnoea treatment for cardiovascular health.

Respirology 2018 Oct 4. Epub 2018 Oct 4.

Monash Lung and Sleep, Monash Medical Centre, Melbourne, VIC, Australia.

Background And Objective: Obstructive sleep apnoea (OSA) is a prevalent sleep disorder associated with increased cardiovascular morbidity and mortality. Whether treatment of OSA improves cardiovascular risk remains controversial. Our aim was to determine a consensus opinion of key sleep medicine stakeholder groups as to the cardiovascular benefits of treating moderate-severe OSA. Read More

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October 2018
4 Reads

The contribution of respiratory microbiome analysis to a treatable traits model of care.

Respirology 2018 Oct 3. Epub 2018 Oct 3.

South Australian Health and Medical Research Institute, Adelaide, SA, Australia.

The composition of the airway microbiome in patients with chronic airway diseases, such as severe asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis and cystic fibrosis (CF), has the potential to inform a precision model of clinical care. Patients with these conditions share overlapping disease characteristics, including airway inflammation and airflow limitation. The clinical management of chronic respiratory conditions is increasingly moving away from a one-size-fits-all model based on primary diagnosis, towards care targeting individual disease traits, and is particularly useful for subgroups of patients who respond poorly to conventional therapies. Read More

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October 2018
2 Reads

Understanding the patient's experience of care in idiopathic pulmonary fibrosis.

Respirology 2018 Oct 3. Epub 2018 Oct 3.

Department of Physiotherapy, Alfred Health, Melbourne, VIC, Australia.

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October 2018
3 Reads

Transcriptomics and single-cell RNA-sequencing.

Respirology 2018 Sep 28. Epub 2018 Sep 28.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.

The past four decades have yielded advances in molecular biology allowing detailed characterization of the cellular genome and the transcriptome: the complete set of RNA species transcribed by a cell or tissue. Through transcriptomics and next-generation sequencing, we can now attain an unprecedented level of detail in understanding cellular phenotypes through examining the genes expressed in specific physiological and pathological states. In this review, we provide an overview of transcriptomics and RNA-sequencing in the analysis of whole tissue and single cells. Read More

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September 2018
6 Reads

Emerging therapies in adult and paediatric bronchiectasis.

Respirology 2018 Dec 21;23(12):1127-1137. Epub 2018 Sep 21.

University of Edinburgh/MRC Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh, UK.

Bronchiectasis is a chronic respiratory disorder characterized by persistent productive cough and recurrent chest infections secondary to permanent structural airway damage. The current treatment strategies for this debilitating disorder are limited to prompt antibiotic treatment of infective exacerbations and regular airway clearance techniques. Despite its high morbidity and associated mortality across all age groups, it has been a neglected area of research in respiratory medicine and there remain no licensed disease-modifying therapies. Read More

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December 2018

Red blood cell transfusion in acute pulmonary embolism.

Respirology 2018 Nov 19;23(11):1076. Epub 2018 Sep 19.

Intensive Care Unit, Dongyang People's Hospital, Jinhua City, China.

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November 2018
2 Reads

Melbourne epidemic thunderstorm asthma event 2016: Lessons learnt from the perfect storm.

Authors:
Francis Thien

Respirology 2018 Nov 19;23(11):976-977. Epub 2018 Sep 19.

Department of Respiratory Medicine, Eastern Health and Monash University, Box Hill Hospital, Melbourne, VIC, Australia.

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November 2018

Triaging treatable traits in asthma.

Respirology 2018 Sep 19. Epub 2018 Sep 19.

Medical Research Institute of New Zealand, Wellington, New Zealand.

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September 2018
3 Reads

Annual decline in arterial blood oxygen predicts development of chronic respiratory failure in COPD with mild hypoxaemia: A 6-year follow-up study.

Respirology 2018 Sep 19. Epub 2018 Sep 19.

Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background And Objective: Chronic respiratory failure (CRF) with hypoxaemia is an important pathophysiology in patients with chronic obstructive pulmonary disease (COPD), and existing mild hypoxaemia may be a sign of future CRF development. However, little is known about the trajectory of partial arterial pressure of oxygen (PaO ) decline in patients with COPD. We assessed decline in PaO and the impact of short-term reductions in PaO to predict future decline in PaO . Read More

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September 2018
1 Read

Treatable traits can be identified in a severe asthma registry and predict future exacerbations.

Respirology 2018 Sep 19. Epub 2018 Sep 19.

Centre of Excellence in Severe Asthma and Priority Research Centre for Healthy Lungs, Faculty of Health, University of Newcastle, Callaghan, NSW, Australia.

Background And Objective: A new taxonomic and management approach, termed treatable traits, has been proposed for airway diseases including severe asthma. This study examined whether treatable traits could be identified using registry data and whether particular treatable traits were associated with future exacerbation risk.

Methods: The Australasian Severe Asthma Web-Based Database (SAWD) enrolled 434 participants with severe asthma and a comparison group of 102 participants with non-severe asthma. Read More

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September 2018
2 Reads
3.500 Impact Factor

Obstructive sleep apnoea and cholesterol: Independence in context.

Respirology 2018 Dec 18;23(12):1092-1093. Epub 2018 Sep 18.

Monash Lung and Sleep, Monash Medical Centre, Melbourne, VIC, Australia.

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December 2018

Modification of the prolonged mechanical ventilation prognostic model score to predict short-term and 1-year mortalities.

Respirology 2018 Sep 17. Epub 2018 Sep 17.

Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background And Objective: We aimed to validate the use of the Prolonged Mechanical Ventilation Prognostic Model (ProVent) score in medically ill patients with co-morbidities and to modify the score to improve the prediction power of 1-year mortality.

Methods: We conducted a retrospective study of all patients who required at least 14 days of mechanical ventilation (MV) and established two groups (14-20 and ≥21 days of MV) based on the MV duration. We performed external validation of the present ProVent Model in our patients on Day 14 (or Day 21 for the ≥21-day MV group) of MV, and established the extended ProVent model, while considering the albumin and bilirubin levels and co-morbidities (chronic obstructive pulmonary disease and cancer). Read More

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September 2018

Insights into respiratory disease through bioinformatics.

Respirology 2018 Dec 14;23(12):1117-1126. Epub 2018 Sep 14.

Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia.

Respiratory diseases such as asthma, chronic obstructive pulmonary disease and lung cancer represent a critical area for medical research as millions of people are affected globally. The development of new strategies for treatment and/or prevention, and the identification of biomarkers for patient stratification and early detection of disease inception are essential to reducing the impact of lung diseases. The successful translation of research into clinical practice requires a detailed understanding of the underlying biology. Read More

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December 2018
2 Reads

Work environment risks for health care workers with cystic fibrosis.

Respirology 2018 Dec 14;23(12):1190-1197. Epub 2018 Sep 14.

Department of Infectious Diseases, Monash Health, Melbourne, VIC, Australia.

In Australia and New Zealand, >50% of people with cystic fibrosis (CF) are adults and many of these people are pursuing vocational training and undertaking paid employment. More than 6% of adults with CF are working in health care. There is limited guidance in literature to support health care workers with CF (HCWcf) in training and in employment to support safe practice and to provide protection for themselves and their patients from the acquisition of health care associated infection. Read More

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December 2018
6 Reads

High-intensity inspiratory muscle training in bronchiectasis: A randomized controlled trial.

Respirology 2018 Sep 12. Epub 2018 Sep 12.

Faculty of Medicine, Department of Chest Medicine, Hacettepe University, Ankara, Turkey.

Background And Objective: Inspiratory muscle training (IMT) enhances velocity of inspiratory muscle contraction and modifies inspiratory and expiratory time. This study aimed to examine the impact of high-intensity IMT (H-IMT) on exercise capacity in bronchiectasis.

Methods: Forty-five patients were included. Read More

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September 2018
10 Reads