2,407 results match your criteria Respiratory Research[Journal]


Progenitor cell mobilisation and recruitment in pulmonary arteries in chronic obstructive pulmonary disease.

Respir Res 2019 Apr 16;20(1):74. Epub 2019 Apr 16.

Department of Pulmonary Medicine, Hospital Clínic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

Background: Pulmonary vascular abnormalities are a characteristic feature of chronic obstructive pulmonary disease (COPD). Cigarette smoking is the most important risk factor for COPD. It is believed that its constant exposure triggers endothelial cell damage and vascular remodelling. Read More

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http://dx.doi.org/10.1186/s12931-019-1024-zDOI Listing

Estimation of early life endogenous surfactant pool and CPAP failure in preterm neonates with RDS.

Respir Res 2019 Apr 16;20(1):75. Epub 2019 Apr 16.

Division of Pediatrics and Neonatal Critical Care, Medical Center "A.Béclère", South Paris University Hospitals, AP-HP, Paris, France.

Background: It is not known if the endogenous surfactant pool available early in life is associated with the RDS clinical course in preterm neonates treated with CPAP. We aim to clarify the clinical factors affecting surfactant pool in preterm neonates and study its association with CPAP failure.

Methods: Prospective, pragmatic, blind, cohort study. Read More

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http://dx.doi.org/10.1186/s12931-019-1040-zDOI Listing

Amelioration of PM-induced lung toxicity in rats by nutritional supplementation with fish oil and Vitamin E.

Respir Res 2019 Apr 16;20(1):76. Epub 2019 Apr 16.

International Collaborative Laboratory for Air Pollution Health Effects and Intervention, School of Public Health, Xinxiang Medical University, 601 Jinsui Street, Xinxiang, 453003, Henan Province, China.

Background: Exposure to fine particulate matter (PM) has been associated with respiratory morbidity and mortality. Identification of interventional measures that are efficacious against PM-induced toxicity may provide public health benefits. This study examined the inhibitory effects of nutritional supplementation with fish oil as a source of omega-3 fatty acids and vitamin E (Vit E) on PM-induced lung toxicity in rats. Read More

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http://dx.doi.org/10.1186/s12931-019-1045-7DOI Listing

Effect of N-acetylcysteine on exacerbations of bronchiectasis (BENE): a randomized controlled trial.

Respir Res 2019 Apr 11;20(1):73. Epub 2019 Apr 11.

Department of Respiratory Medicine, Qilu Hospital of Shandong University, No. 107 Wenhua Xilu, Jinan, 250012, Shandong Province, China.

Background: N-acetylcysteine is a classic mucolytic agent. This study aimed to investigate the efficacy of N-acetylcysteine on reducing the risk of exacerbations in bronchiectasis patients.

Methods: A prospective, randomized, controlled trial was conducted between April 1, 2014 and December 31, 2016 in five general hospitals in Shandong Province, China. Read More

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http://dx.doi.org/10.1186/s12931-019-1042-xDOI Listing
April 2019
1 Read

Salicylic acid amplifies Carbachol-induced bronchoconstriction in human precision-cut lung slices.

Respir Res 2019 Apr 11;20(1):72. Epub 2019 Apr 11.

Rutgers Institute for Translational Medicine and Science (RITMS), Rutgers, The State University of New Jersey, Rm# 4276, 89 French Street, New Brunswick, NJ08901, USA.

Background: Asthma exacerbations evoke emergency room visits, progressive loss of lung function and increased mortality. Environmental and industrial toxicants exacerbate asthma, although the underlying mechanisms are unknown. We assessed whether 3 distinct toxicants, salicylic acid (SA), toluene diisocyanate (TDI), and 1-chloro-2,4-dinitrobenzene (DNCB) induced airway hyperresponsiveness (AHR) through modulating excitation-contraction coupling in human airway smooth muscle (HASM) cells. Read More

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http://dx.doi.org/10.1186/s12931-019-1034-xDOI Listing

AGER expression and alternative splicing in bronchial biopsies of smokers and never smokers.

Respir Res 2019 Apr 10;20(1):70. Epub 2019 Apr 10.

Department of Pathology & Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.

Cigarette smoking is one of the major risk factors for the development of chronic obstructive pulmonary disease (COPD). Evidence is accumulating that Receptor for Advanced Glycation-End products (RAGE)-signaling is a key pathway in the pathophysiology of COPD. To date, it is unknown how smoking affects RAGE expression. Read More

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http://dx.doi.org/10.1186/s12931-019-1038-6DOI Listing
April 2019
2 Reads

Differing severities of acute exacerbations of idiopathic pulmonary fibrosis (IPF): insights from the INPULSIS® trials.

Respir Res 2019 Apr 11;20(1):71. Epub 2019 Apr 11.

Università Cattolica del Sacro Cuore, Fondazione Policlinico A. Gemelli, Rome, Italy.

Background: Given the broad definition of an acute exacerbation of IPF, it is likely that acute exacerbations are heterogeneous in their aetiology, severity and clinical course. We used pooled data from the INPULSIS® trials of nintedanib versus placebo to investigate whether acute exacerbations reported as serious adverse events were associated with higher mortality than those reported as non-serious adverse events and to assess the effect of nintedanib on these types of events.

Methods: Adverse events considered by an investigator to be an acute exacerbation were adjudicated as a confirmed acute exacerbation, suspected acute exacerbation, or not an acute exacerbation. Read More

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http://dx.doi.org/10.1186/s12931-019-1037-7DOI Listing
April 2019
1 Read

Safety maximization of percutaneous transthoracic needle biopsy with ultrasound guide in subpleural lesions in the evaluation of pulmonary consolidation.

Respir Res 2019 Apr 5;20(1):68. Epub 2019 Apr 5.

Department of Medical and Surgical Sciences, Institute of Respiratory Disease, University of Foggia, Viale degli Aviatori, 2, 71122, Foggia, FG, Italy.

The study by Kiranantawat et al. "Clinical role, safety and diagnostic accuracy of percutaneous transthoracic needle biopsy in the evaluation of pulmonary consolidation" highlights how "pulmonary consolidation can be safely evaluated with CT-guided percutaneous needle biopsy". Even if we agree about the role of CT guidance, we would like to point out how Thoracic Ultrasound could be better than CT for biopsy of subpleural lesions that could easily be detected and reached with this "real-time" and quicker technique. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-019-1031-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451297PMC
April 2019
3 Reads

Metformin use mitigates the adverse prognostic effect of diabetes mellitus in chronic obstructive pulmonary disease.

Respir Res 2019 Apr 5;20(1):69. Epub 2019 Apr 5.

Department of Internal Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, 100, Taiwan.

Background And Objective: Among patients with chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM) is a common comorbidity and is probably associated with increased systemic inflammation and worse prognosis. Metformin, with its pleiotropic anti-inflammatory and antioxidant actions, may offer theoretical benefits in COPD patients with DM. Thus, this study aimed to investigate the effects of DM and metformin use on mortality in the clinical trajectory of COPD. Read More

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http://dx.doi.org/10.1186/s12931-019-1035-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451256PMC
April 2019
1 Read

Altered irisin/BDNF axis parallels excessive daytime sleepiness in obstructive sleep apnea patients.

Respir Res 2019 Apr 5;20(1):67. Epub 2019 Apr 5.

Department of Health Systems Management and Quality Management for Health Care, Faculty of Public Health, University of Debrecen, Nagyerdei krt. 98, Debrecen, 4032, Hungary.

Study Objectives: Obstructive sleep apnea hypopnea syndrome (OSAHS) is a sleep-related breathing disorder, characterized by excessive daytime sleepiness (EDS), paralleled by intermittent collapse of the upper airway. EDS may be the symptom of OSAHS per se but may also be due to the alteration of central circadian regulation. Irisin is a putative myokine and has been shown to induce BDNF expression in several sites of the brain. Read More

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http://dx.doi.org/10.1186/s12931-019-1033-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449996PMC
April 2019
1 Read

Effective nebulization of interferon-γ using a novel vibrating mesh.

Respir Res 2019 Apr 3;20(1):66. Epub 2019 Apr 3.

Aerogen, IDA Business Park, Dangan, Galway, Ireland.

Background: Interferon gamma (IFN-γ) is a clinically relevant immunomodulatory cytokine that has demonstrated significant potential in the treatment and management of respiratory diseases such as tuberculosis and pulmonary fibrosis. As with all large biomolecules, clinical translation is dependent on effective delivery to the disease site and delivery of IFN-γ as an aerosol offers a logical means of drug targeting. Effective localization is often hampered by instability and a lack of safe and efficient delivery systems. Read More

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http://dx.doi.org/10.1186/s12931-019-1030-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448243PMC
April 2019
2 Reads

Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: a large-scale genome-wide cross-trait analysis.

Respir Res 2019 Apr 2;20(1):64. Epub 2019 Apr 2.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Background: A growing number of studies clearly demonstrate a substantial association between chronic obstructive pulmonary disease (COPD) and cardiovascular diseases (CVD), although little is known about the shared genetics that contribute to this association.

Methods: We conducted a large-scale cross-trait genome-wide association study to investigate genetic overlap between COPD (N = 12,550, N = 46,368) from the International COPD Genetics Consortium and four primary cardiac traits: resting heart rate (RHR) (N = 458,969), high blood pressure (HBP) (N = 144,793, N = 313,761), coronary artery disease (CAD)(N = 60,801, N = 123,504), and stroke (N = 40,585, N = 406,111) from UK Biobank, CARDIoGRAMplusC4D Consortium, and International Stroke Genetics Consortium data.

Results: RHR and HBP had modest genetic correlation, and CAD had borderline evidence with COPD at a genome-wide level. Read More

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http://dx.doi.org/10.1186/s12931-019-1036-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444755PMC
April 2019
1 Read

RNA-sequencing across three matched tissues reveals shared and tissue-specific gene expression and pathway signatures of COPD.

Respir Res 2019 Apr 2;20(1):65. Epub 2019 Apr 2.

Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA.

Background: Multiple gene expression studies have been performed separately in peripheral blood, lung, and airway tissues to study COPD. We performed RNA-sequencing gene expression profiling of large-airway epithelium, alveolar macrophage and peripheral blood samples from the same subset of COPD cases and controls from the COPDGene study who underwent bronchoscopy at a single center. Using statistical and gene set enrichment approaches, we sought to improve the understanding of COPD by studying gene sets and pathways across these tissues, beyond the individual genomic determinants. Read More

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http://dx.doi.org/10.1186/s12931-019-1032-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446359PMC
April 2019
1 Read

Type IV collagen turnover is predictive of mortality in COPD: a comparison to fibrinogen in a prospective analysis of the ECLIPSE cohort.

Respir Res 2019 Apr 1;20(1):63. Epub 2019 Apr 1.

Nordic Bioscience A/S, Herlev, Denmark.

Background: Identifying subjects with chronic obstructive pulmonary disease (COPD) at high risk of exacerbation and mortality is key to aid individual management of COPD. The only FDA approved blood-based drug development biomarker for patients at high risk of mortality, is plasma fibrinogen. In this study, we benchmarked two biomarkers of basement membrane remodeling, a characteristic of COPD, against plasma fibrinogen alone and as a combination. Read More

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http://dx.doi.org/10.1186/s12931-019-1026-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444812PMC
April 2019
2 Reads

Change in inhaled corticosteroid treatment and COPD exacerbations: an analysis of real-world data from the KOLD/KOCOSS cohorts.

Respir Res 2019 Mar 28;20(1):62. Epub 2019 Mar 28.

Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background: This cohort study of patients with chronic obstructive pulmonary disease (COPD) was performed to evaluate the status of inhaled corticosteroid (ICS) prescriptions following the 2017 revision of the Global Initiative for Chronic Obstructive Lung Disease guidelines.

Methods: A total of 1144 patients from the Korean Obstructive Lung Disease and Korea Chronic Obstructive Pulmonary Disorders Subgroup Study cohorts, with final follow-up visits completed between 2017 and 2018, were analyzed. Features indicative of ICS usage were as follows: a history of asthma, blood eosinophils of ≥300 cells/μl, or ≥ 2 exacerbations in the year prior to enrollment. Read More

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http://dx.doi.org/10.1186/s12931-019-1029-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437901PMC
March 2019
1 Read

Effects of airway obstruction and hyperinflation on electrocardiographic axes in COPD.

Respir Res 2019 Mar 27;20(1):61. Epub 2019 Mar 27.

Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig Maximilians University (LMU), Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Ziemssenstrasse 1, 80336, Munich, Germany.

Background: COPD influences cardiac function and morphology. Changes of the electrical heart axes have been largely attributed to a supposed increased right heart load in the past, whereas a potential involvement of the left heart has not been sufficiently addressed. It is not known to which extent these alterations are due to changes in lung function parameters. Read More

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http://dx.doi.org/10.1186/s12931-019-1025-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437876PMC

Impact of prior and concurrent medication on exacerbation risk with long-acting bronchodilators in chronic obstructive pulmonary disease: a post hoc analysis.

Respir Res 2019 Mar 26;20(1):60. Epub 2019 Mar 26.

Global Respiratory Franchise, GSK, 980 Great West Road, Brentford, Middlesex, TW8 9GS, UK.

Background: Symptomatic patients with chronic obstructive pulmonary disease (COPD) and low exacerbation risk still have disease instability, which can be improved with better bronchodilation. We evaluated two long-acting bronchodilators individually and in combination on reducing exacerbation risk and the potential impact of concurrent medication in these patients.

Methods: Integrated post hoc intent-to-treat (ITT) analysis of data from two large 24-week, randomized placebo (PBO)-controlled trials (NCT01313637, NCT01313650). Read More

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http://dx.doi.org/10.1186/s12931-019-1027-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434823PMC
March 2019
3 Reads

The clinical course of idiopathic pulmonary fibrosis and its association to quality of life over time: longitudinal data from the INSIGHTS-IPF registry.

Respir Res 2019 Mar 15;20(1):59. Epub 2019 Mar 15.

Medizinische Klinik und Poliklinik V, Klinikum der LMU, Munich, Germany.

Background: Quality of life (QoL) is profoundly impaired in patients with idiopathic pulmonary fibrosis (IPF). However, data is limited regarding the course of QoL. We therefore analysed longitudinal data from the German INSIGHTS-IPF registry. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-019-1020-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420774PMC
March 2019
6 Reads

Noninvasive high-frequency oscillatory ventilation as respiratory support in preterm infants: a meta-analysis of randomized controlled trials.

Respir Res 2019 Mar 15;20(1):58. Epub 2019 Mar 15.

Department of Neonatology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, China, No. 261 Huansha Road, Hangzhou City, Zhejiang, 310002, China.

Background: Noninvasive high-frequency oscillatory ventilation (nHFOV), a relatively new modality, is gaining popularity despite scarce evidence. This meta-analysis was designed to evaluate the efficacy and safety of nHFOV as respiratory support in premature infants.

Methods: We searched MEDLINE, EMBASE, CINAHL, and Cochrane CENTRAL from inception of the database to January 2019. Read More

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http://dx.doi.org/10.1186/s12931-019-1023-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420773PMC

The natural history of progressive fibrosing interstitial lung diseases.

Respir Res 2019 Mar 14;20(1):57. Epub 2019 Mar 14.

Department of Respiratory Medicine, Thomayer Hospital, Videnska 800, 14059, Prague, Czech Republic.

A proportion of patients with certain types of interstitial lung disease (ILD), including chronic hypersensitivity pneumonitis and ILDs associated with autoimmune diseases, develop a progressive fibrosing phenotype that shows similarities in clinical course to idiopathic pulmonary fibrosis. Irrespective of the clinical diagnosis, these progressive fibrosing ILDs show commonalities in the underlying pathogenetic mechanisms that drive a self-sustaining process of pulmonary fibrosis. The natural history of progressive fibrosing ILDs is characterized by decline in lung function, worsening of symptoms and health-related quality of life, and early mortality. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-019-1022-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417262PMC
March 2019
7 Reads

Investigating the role of circulating CXCR5-expressing CD8+ T-cells as a biomarker for bacterial infection in subjects with pneumonia.

Respir Res 2019 Mar 12;20(1):54. Epub 2019 Mar 12.

Clinical Immunology Laboratory, the First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, China.

Background: Recently, lymphoid follicle-confined and circulating CD8+ T-cells expressing the C-X-C chemokine receptor type 5 (CXCR5) were described, which was involved in anti-virus immune response. However, the dynamics and role of circulating CXCR5-expressing CD8+ T-cells during bacterial infection is unknown. So, we asked whether CXCR5+ CD8+ T cells were also generated during bacterial infections in lower respiratory tract. Read More

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http://dx.doi.org/10.1186/s12931-019-1011-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417220PMC
March 2019
3 Reads

Body composition, muscle function, and physical performance in fibrotic interstitial lung disease: a prospective cohort study.

Respir Res 2019 Mar 12;20(1):56. Epub 2019 Mar 12.

Department of Medicine, University of British Columbia, Vancouver, Canada.

Background: Patients with fibrotic interstitial lung disease (ILD) are frequently physically inactive and many ILD subtypes are characterized by risk factors for myopathy; however, the importance of body composition, muscle strength, and physical performance in this population is largely unknown.

Methods: Patients were prospectively recruited from a specialized ILD clinic, baseline characteristics were collected from the clinical record, pulmonary function tests were performed per established protocols, and dyspnea was measured using the University of California San Diego Shortness of Breath Questionnaire. Dual-energy X-ray absorptiometry (DXA) was used to assess body composition; handgrip strength to determine muscle strength, and 4-m gait speed to measure physical performance. Read More

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http://dx.doi.org/10.1186/s12931-019-1019-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417197PMC
March 2019
3 Reads

Effect of pirfenidone in patients with more advanced idiopathic pulmonary fibrosis.

Respir Res 2019 Mar 12;20(1):55. Epub 2019 Mar 12.

Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA.

Data from controlled clinical studies in patients with more advanced idiopathic pulmonary fibrosis (IPF) could inform clinical practice, but they are limited, since this sub-population is usually excluded from clinical trials. These exploratory post-hoc analyses of the open-label, long-term extension study RECAP (NCT00662038) aimed to assess the efficacy and safety of pirfenidone in patients with more advanced IPF. Patients were categorised according to the extent of lung function impairment at baseline: more advanced (percent predicted FVC <50% and/or DLco <35%) and less advanced (percent predicted FVC ≥50% and DLco ≥35%). Read More

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http://dx.doi.org/10.1186/s12931-019-1021-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416878PMC
March 2019
1 Read

Long non-coding RNA CASC2 suppresses pulmonary artery smooth muscle cell proliferation and phenotypic switch in hypoxia-induced pulmonary hypertension.

Respir Res 2019 Mar 11;20(1):53. Epub 2019 Mar 11.

Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, No.167 Beilishi Rd., Xicheng District, Beijing, 100037, China.

Background: In this study, we aimed to investigate whether and how lncRNA CASC2 was involved in hypoxia-induced pulmonary hypertension (PH)-related vascular remodeling.

Methods: The expression of lncRNAs or mRNAs was detected by qRT-PCR, and western blot analysis or immunochemistry was employed for detecting the protein expression. Cell number assay and EdU (5-ethynyl-2'-deoxyuridine) staining were performed to assess cell proliferation. Read More

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http://dx.doi.org/10.1186/s12931-019-1018-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413462PMC

Role of RASEF hypermethylation in cigarette smoke-induced pulmonary arterial smooth muscle remodeling.

Respir Res 2019 Mar 7;20(1):52. Epub 2019 Mar 7.

Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Background: Pulmonary hypertension (PH) is a progressive and fatal disease. While cigarette smoke can change DNA methylation status, the role of such molecular alterations in smoke-associated PH is unclear.

Methods: A PH rat model was developed by exposing animals to cigarette smoke for 3 months. Read More

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http://dx.doi.org/10.1186/s12931-019-1014-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407244PMC
March 2019
1 Read

Ovalbumin-sensitized mice have altered airway inflammation to agriculture organic dust.

Respir Res 2019 Mar 7;20(1):51. Epub 2019 Mar 7.

Pulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, NE, 68198-5910, USA.

Agriculture exposures are associated with reducing the risk of allergy and asthma in early life; yet, repeated exposures later in life are associated with chronic bronchitis and obstructive pulmonary diseases. The objective of this study was to investigate the airway inflammatory response to organic dust extract (ODE) in mice with established ovalbumin (OVA)-induced experimental asthma. C57BL/6 mice were either OVA sensitized/aerosol-exposed or saline (Sal) sensitized/aerosol-challenged. Read More

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http://dx.doi.org/10.1186/s12931-019-1015-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407255PMC
March 2019
2 Reads

Prognostic value of serum macrophage migration inhibitory factor levels in pulmonary tuberculosis.

Respir Res 2019 Mar 6;20(1):50. Epub 2019 Mar 6.

Department of Tuberculosis, The first affiliated Hospital of Xinxiang Medical University, No.88, Jiankang road, Weihui, Xinxiang, 453100, China.

Background: Macrophage migration inhibitory factor (MIF) makes chemokine-like functions and plays critical roles in various inflammatory diseases. This study was designed to explore the significance of MIF serum levels in predicting the prognosis of pulmonary tuberculosis (PTB) following anti-TB treatment.

Methods: Patients diagnosed with culture-confirmed PTB without treatment were included and the serum was collected. Read More

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http://dx.doi.org/10.1186/s12931-019-1004-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402089PMC
March 2019
1 Read

Down-regulation of microRNA-144-3p and its clinical value in non-small cell lung cancer: a comprehensive analysis based on microarray, miRNA-sequencing, and quantitative real-time PCR data.

Respir Res 2019 Mar 4;20(1):48. Epub 2019 Mar 4.

Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Shuangrong Road, Nanning, Guangxi Zhuang Autonomous Region, 530021, People's Republic of China.

Background: Previous studies have shown that miR-144-3p might be a potential biomarker in non-small cell lung cancer (NSCLC). Nevertheless, the comprehensive mechanism behind the effects of miR-144-3p on the origin, differentiation, and apoptosis of NSCLC, as well as the relationship between miR-144-3p and clinical parameters, has been rarely reported.

Methods: We investigated the correlations between miR-144-3p expression and clinical characteristics through data collected from Gene Expression Omnibus (GEO) microarrays, the relevant literature, The Cancer Genome Atlas (TCGA), and real-time quantitative real-time PCR (RT-qPCR) analyses to determine the clinical role of miR-144-3p in NSCLC. Read More

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http://dx.doi.org/10.1186/s12931-019-0994-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399847PMC
March 2019
1 Read

The pathology of small airways disease in COPD: historical aspects and future directions.

Respir Res 2019 Mar 4;20(1):49. Epub 2019 Mar 4.

The University of Manchester Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.

Small airways disease (SAD) is a cardinal feature of chronic obstructive pulmonary disease (COPD) first recognized in the nineteenth century. The diverse histopathological features associated with SAD underpin the heterogeneous nature of COPD. Our understanding of the key molecular mechanisms which drive the pathological changes are not complete. Read More

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http://dx.doi.org/10.1186/s12931-019-1017-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399904PMC
March 2019
1 Read

Psychometric properties and minimal important differences of SF-36 in Idiopathic Pulmonary Fibrosis.

Respir Res 2019 Mar 1;20(1):47. Epub 2019 Mar 1.

European IPF Registry & Biobank (eurIPFreg/bank), Giessen, Germany.

Background: Idiopathic pulmonary fibrosis (IPF) is a rare disease with a median survival of 3-5 years after diagnosis with limited treatment options. The aim of this study is to assess the psychometric characteristics of the Short Form 36 Health Status Questionnaire (SF-36) in IPF and to provide disease specific minimally important differences (MID).

Methods: Data source was the European IPF Registry (eurIPFreg). Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-019-1010-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397447PMC
March 2019
6 Reads

Prognostic impact of residual SYNTAX score in patients with obstructive sleep apnea and acute coronary syndrome: a prospective cohort study.

Respir Res 2019 Feb 28;20(1):43. Epub 2019 Feb 28.

Department of Otolaryngology Head & Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, 2nd Anzhen Road, Chaoyang District, Beijing, 100029, China.

Background: There is a paucity of data from large prospective study evaluating the prognostic significance of the residual Synergy between percutaneous intervention with Taxus drug-eluting stents and cardiac surgery (SYNTAX) Score (rSS) in patients with obstructive sleep apnea (OSA) and Acute Coronary Syndrome (ACS).

Methods: ACS patients who undergoing percutaneous coronary angiography and completing a sleep study during hospitalization were prospectively enrolled. The baseline SYNTAX Score (bSS) and the rSS after revascularization were assessed. Read More

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http://dx.doi.org/10.1186/s12931-019-1008-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393988PMC
February 2019
1 Read

The composition of the pulmonary microbiota in sarcoidosis - an observational study.

Respir Res 2019 Feb 28;20(1):46. Epub 2019 Feb 28.

Department of Internal Medicine V - Pulmonology, Allergology, Critical Care Medicine, Saarland University Hospital, Homburg, Germany.

Background: Sarcoidosis is a systemic disease of unknown etiology. The disease mechanisms are largely speculative and may include the role microbial patterns that initiate and drive an underlying immune process. The aim of this study was to characterize the microbiota of the lung of patients with sarcoidosis and compare its composition and diversity with the results from patients with other interstitial lung disease (ILD) and historic healthy controls. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-019-1013-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396534PMC
February 2019
6 Reads

Regional lung densities in alpha-1 antitrypsin deficiency compared to predicted values.

Respir Res 2019 Feb 28;20(1):45. Epub 2019 Feb 28.

Department of Respiratory Medicine, University Hospitals of Coventry and Warwickshire, Clifford Bridge Road, Coventry, UK.

Background: We developed a method to calculate a standard score for lung tissue mass derived from CT scan images from a control group without respiratory disease. We applied the method to images from subjects with emphysema associated with alpha-1 antitrypsin deficiency (AATD) and used it to study regional patterns of differential tissue mass.

Methods: We explored different covariates in 76 controls. Read More

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http://dx.doi.org/10.1186/s12931-019-1012-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396535PMC
February 2019
1 Read

Extent, trends, and determinants of controller/reliever balance in mild asthma: a 14-year population-based study.

Respir Res 2019 Feb 28;20(1):44. Epub 2019 Feb 28.

Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, the University of British Columbia, Vancouver, Canada.

Background: The majority of patients with asthma have the mild form of the disease. Whether mild asthma patients receive appropriate asthma medications has not received much attention in the literature. We examined the trends in indicators of controller/reliever balance. Read More

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http://dx.doi.org/10.1186/s12931-019-1007-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394061PMC
February 2019

Pulmonary arterial remodelling by deficiency of peroxisome proliferator-activated receptor-γ in murine vascular smooth muscle cells occurs independently of obesity-related pulmonary hypertension.

Respir Res 2019 Feb 27;20(1):42. Epub 2019 Feb 27.

Berlin Institute of Health, Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Center for Cardiovascular Research (CCR), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Background: Obesity is associated with cardiovascular complications, including pulmonary hypertension (PH). Reports suggest that peroxisome proliferator-activated receptor-γ (PPARγ) has direct action in preventing vascular remodelling in PH. Here we dissected the specific role of high-fat-diet (HFD)-induced obesity and vascular smooth muscle cell (VSMC)-PPARγ for remodelling of small pulmonary arteries. Read More

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http://dx.doi.org/10.1186/s12931-019-1003-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391752PMC
February 2019
1 Read

Comparison of therapeutic effects of inhaled corticosteroids on three subtypes of cough variant asthma as classified by the impulse oscillometry system.

Respir Res 2019 Feb 26;20(1):41. Epub 2019 Feb 26.

Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, 060-8543, Japan.

Background: Cough variant asthma (CVA) is one of the most common causes of chronic persistent cough, and early treatment with inhaled corticosteroids (ICSs) is recommended to attenuate the inflammation and remodeling. The impulse oscillometry system (IOS) is a novel device for respiratory functional assessment that has not yet been assessed in terms of CVA. Therefore, we investigated the relationship between CVA and IOS, and the difference in therapeutic effects of ICSs among the subtype classifications by IOS. Read More

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http://dx.doi.org/10.1186/s12931-019-1005-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390374PMC
February 2019
2 Reads

Use of Berlin questionnaire in comparison to polysomnography and home sleep study in patients with obstructive sleep apnea.

Respir Res 2019 Feb 22;20(1):40. Epub 2019 Feb 22.

Division of Respiratory Medicine, The Chinese University of Hong Kong, Sha Tin, Hong Kong.

Background: Obstructive sleep apnea syndrome (OSAS) is a common disorder with significant morbidity and mortality. We aimed to evaluate the predictive accuracy of the Berlin questionnaire in patients with suspected OSAS undergoing PSG in the sleep laboratory setting against those going through the Embletta™ portable diagnostic system (Embletta PDS) at home.

Methods: Patients with suspected OSAS were recruited from respiratory clinics to complete Berlin questionnaire and Epworth Sleepiness Score (ESS). Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-019-1009-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387538PMC
February 2019
9 Reads

An evaluation of the effects of saffron supplementation on the asthma clinical symptoms and asthma severity in patients with mild and moderate persistent allergic asthma: a double-blind, randomized placebo-controlled trial.

Respir Res 2019 Feb 22;20(1):39. Epub 2019 Feb 22.

Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Asthma is a heterogeneous disease which is usually associated with chronic airway inflammation. Saffron has anti-inflammatory effects and may has beneficial effects on asthma.

Hypothesis: The present study was intended to survey the effects of saffron supplementation on blood pressure, lipid profiles, basophils, eosinophils and clinical symptoms in patients with allergic asthma. Read More

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http://dx.doi.org/10.1186/s12931-019-0998-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387530PMC
February 2019

Association between ADAM33 polymorphisms and asthma risk: a systematic review and meta-analysis.

Respir Res 2019 Feb 21;20(1):38. Epub 2019 Feb 21.

Department of Respiratory Medicine, Weifang People's Hospital, Weifang, 261041, Shandong, China.

Background: Asthma is a common complex chronic, inflammatory polygenic disease with heterogeneous manifestations, affecting individuals of all age groups and posing an immense burden on healthcare resources. A number of studies have identified the association between a disintegrin and metalloprotease 33 (ADAM33) polymorphisms and asthma risk, however, the results still remain inconclusive. The objective of the present study was to identify the effect of ADAM33 variants in asthma susceptibility. Read More

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http://dx.doi.org/10.1186/s12931-019-1006-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385425PMC
February 2019
1 Read

Efficacy and safety of AZD7594, an inhaled non-steroidal selective glucocorticoid receptor modulator, in patients with asthma: a phase 2a randomized, double blind, placebo-controlled crossover trial.

Respir Res 2019 Feb 18;20(1):37. Epub 2019 Feb 18.

Respiratory, Inflammation and Autoimmunity Translational Medicine Unit, Early Clinical Development, IMED Biotech Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.

Background: Inhaled corticosteroids reduce inflammation in asthma but chronic use may cause adverse effects. AZD7594, an inhaled non-steroidal selective glucocorticoid receptor modulator, has the potential of an improved risk-benefit profile. We investigated the safety and efficacy of AZD7594 in asthma. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-019-1000-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380015PMC
February 2019
2 Reads

Handover of the Editor in Chief positions - from the new Editors-in-Chief to the readership of Respiratory Research.

Respir Res 2019 Feb 19;20(1):25. Epub 2019 Feb 19.

Kliniken der Stadt Köln gGmbH, Klinikum der Privaten Universität Witten Herdecke, Ostmerheimer Str. 200, D-51109, Cologne, Germany.

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http://dx.doi.org/10.1186/s12931-019-0989-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379955PMC
February 2019

Identification of differentially expressed proteins in the injured lung from zinc chloride smoke inhalation based on proteomics analysis.

Respir Res 2019 Feb 15;20(1):36. Epub 2019 Feb 15.

Department of Respiratory, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.

Background: Lung injury due to zinc chloride smoke inhalation is very common in military personnel and leads to a high incidence of pulmonary complications and mortality. The aim of this study was to uncover the underlying mechanisms of lung injury due to zinc chloride smoke inhalation using a rat model.

Methods: Histopathology analysis of rat lungs after zinc chloride smoke inhalation was performed by using haematoxylin and eosin (H&E) and Mallory staining. Read More

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http://dx.doi.org/10.1186/s12931-019-0995-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377712PMC
February 2019
4 Reads

Thoracic skeletal muscle quantification: low muscle mass is related with worse prognosis in idiopathic pulmonary fibrosis patients.

Respir Res 2019 Feb 15;20(1):35. Epub 2019 Feb 15.

Division of Pulmonary Medicine Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea.

Background: Sarcopenia can contribute to negative outcomes in patients with various lung diseases. However, whether sarcopenia affects prognosis in patients with idiopathic pulmonary fibrosis (IPF) has not been reported. Simple measures of muscle mass, derived from chest computed tomography (CT), are increasingly being used to identify patients with sarcopenia. Read More

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http://dx.doi.org/10.1186/s12931-019-1001-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376641PMC
February 2019
2 Reads

Second-hand smoke exposure in adulthood and lower respiratory health during 20 year follow up in the European Community Respiratory Health Survey.

Respir Res 2019 Feb 14;20(1):33. Epub 2019 Feb 14.

Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.

Background: Early life exposure to tobacco smoke has been extensively studied but the role of second-hand smoke (SHS) for new-onset respiratory symptoms and lung function decline in adulthood has not been widely investigated in longitudinal studies. Our aim is to investigate the associations of exposure to SHS in adults with respiratory symptoms, respiratory conditions and lung function over 20 years.

Methods: We used information from 3011 adults from 26 centres in 12 countries who participated in the European Community Respiratory Health Surveys I-III and were never or former smokers at all three surveys. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-019-0996-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376659PMC
February 2019
8 Reads

Persistent exercise limitation after successful pulmonary endoarterectomy: frequency and determinants.

Respir Res 2019 Feb 14;20(1):34. Epub 2019 Feb 14.

Division of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Viale Golgi 19, 27100, Pavia, Italy.

Background: After successful pulmonary endoarterectomy (PEA), patients may still suffer from exercise limitation, despite normal pulmonary vascular resistance. We sought to assess the proportion of these patients after the extension of PEA to frail patients, and the determinants of exercise limitation.

Methods: Out of 553 patients treated with PEA from 2008 to 2016 at our institution, a cohort of 261 patients was followed up at 12 months. Read More

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http://dx.doi.org/10.1186/s12931-019-1002-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376724PMC
February 2019
1 Read

Desmin and dystrophin abnormalities in upper airway muscles of snorers and patients with sleep apnea.

Respir Res 2019 Feb 14;20(1):31. Epub 2019 Feb 14.

Department of Integrative Medical Biology, Laboratory of Muscle Biology, Umeå University, SE-901 87, Umeå, Sweden.

Background: The pathophysiology of obstruction and swallowing dysfunction in snores and sleep apnea patients remains unclear. Neuropathy and to some extent myopathy have been suggested as contributing causes. Recently we reported an absence and an abnormal isoform of two cytoskeletal proteins, desmin, and dystrophin, in upper airway muscles of healthy humans. Read More

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http://dx.doi.org/10.1186/s12931-019-0999-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376723PMC
February 2019
1 Read

Is cellular senescence involved in cystic fibrosis?

Respir Res 2019 Feb 14;20(1):32. Epub 2019 Feb 14.

Cystic Fibrosis Center, Azienda Ospedaliera Universitaria Ospedali Riuniti, 60121, Ancona, Italy.

Pulmonary disease is the main cause of the morbidity and mortality of patients affected by cystic fibrosis (CF). The lung pathology is dominated by excessive recruitment of neutrophils followed by an exaggerated inflammatory process that has also been reported to occur in the absence of apparent pathogenic infections. Airway surface dehydration and mucus accumulation are the driving forces of this process. Read More

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http://dx.doi.org/10.1186/s12931-019-0993-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376730PMC
February 2019
4 Reads

Effect of COPD severity and comorbidities on the result of the PHQ-9 tool for the diagnosis of depression: results from the COSYCONET cohort study.

Respir Res 2019 Feb 11;20(1):30. Epub 2019 Feb 11.

Department of Internal Medicine V, University of Munich (LMU), Ziemssenstr. 1, 80336, Munich, Germany.

The diagnosis of depression, a frequent comorbidity of chronic obstructive pulmonary disease (COPD), is often supported by questionnaires, such as the Patient Health Questionnaire 9 (PHQ-9). It is unknown to which extent its single questions are affected by the clinical characteristics of COPD patients.We addressed this question in 2255 GOLD grade 1-4 patients from the COSYCONET (COPD and Systemic Consequences - Comorbidities Network) COPD cohort. Read More

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http://dx.doi.org/10.1186/s12931-019-0997-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371561PMC
February 2019
6 Reads

What links ventilator driving pressure with survival in the acute respiratory distress syndrome? A computational study.

Respir Res 2019 Feb 11;20(1):29. Epub 2019 Feb 11.

School of Engineering, University of Warwick, Coventry, UK.

Background: Recent analyses of patient data in acute respiratory distress syndrome (ARDS) showed that a lower ventilator driving pressure was associated with reduced relative risk of mortality. These findings await full validation in prospective clinical trials.

Methods: To investigate the association between driving pressures and ventilator induced lung injury (VILI), we calibrated a high fidelity computational simulator of cardiopulmonary pathophysiology against a clinical dataset, capturing the responses to changes in mechanical ventilation of 25 adult ARDS patients. Read More

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http://dx.doi.org/10.1186/s12931-019-0990-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371576PMC
February 2019
8 Reads

BAMBI regulates macrophages inducing the differentiation of Treg through the TGF-β pathway in chronic obstructive pulmonary disease.

Respir Res 2019 Feb 6;20(1):26. Epub 2019 Feb 6.

Department of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China.

Background: Chronic obstructive pulmonary disease (COPD) is characterized by continuous flow limitation and the immune system including macrophages and regulatory T lymphocytes (Tregs) is involved in COPD pathogenesis. In our previous study, we investigated that TGF-β/BAMBI pathway was associated with COPD by regulating the balance of Th17/Treg. However, the role of bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI), a pseudoreceptor of TGF-β signalling pathway, in regulating the immune system of COPD patients has not been fully studied. Read More

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http://dx.doi.org/10.1186/s12931-019-0988-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364453PMC
February 2019
1 Read