2,369 results match your criteria Respiratory Research[Journal]


Association between ADAM33 polymorphisms and asthma risk: a systematic review and meta-analysis.

Respir Res 2019 Feb 21;20(1):38. Epub 2019 Feb 21.

Department of Respiratory Medicine, Weifang People's Hospital, Weifang, 261041, Shandong, China.

Background: Asthma is a common complex chronic, inflammatory polygenic disease with heterogeneous manifestations, affecting individuals of all age groups and posing an immense burden on healthcare resources. A number of studies have identified the association between a disintegrin and metalloprotease 33 (ADAM33) polymorphisms and asthma risk, however, the results still remain inconclusive. The objective of the present study was to identify the effect of ADAM33 variants in asthma susceptibility. Read More

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http://dx.doi.org/10.1186/s12931-019-1006-1DOI Listing
February 2019

Efficacy and safety of AZD7594, an inhaled non-steroidal selective glucocorticoid receptor modulator, in patients with asthma: a phase 2a randomized, double blind, placebo-controlled crossover trial.

Respir Res 2019 Feb 18;20(1):37. Epub 2019 Feb 18.

Respiratory, Inflammation and Autoimmunity Translational Medicine Unit, Early Clinical Development, IMED Biotech Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.

Background: Inhaled corticosteroids reduce inflammation in asthma but chronic use may cause adverse effects. AZD7594, an inhaled non-steroidal selective glucocorticoid receptor modulator, has the potential of an improved risk-benefit profile. We investigated the safety and efficacy of AZD7594 in asthma. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-019-1000-7DOI Listing
February 2019
1 Read

Handover of the Editor in Chief positions - from the new Editors-in-Chief to the readership of Respiratory Research.

Respir Res 2019 Feb 19;20(1):25. Epub 2019 Feb 19.

Kliniken der Stadt Köln gGmbH, Klinikum der Privaten Universität Witten Herdecke, Ostmerheimer Str. 200, D-51109, Cologne, Germany.

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http://dx.doi.org/10.1186/s12931-019-0989-yDOI Listing
February 2019

Identification of differentially expressed proteins in the injured lung from zinc chloride smoke inhalation based on proteomics analysis.

Respir Res 2019 Feb 15;20(1):36. Epub 2019 Feb 15.

Department of Respiratory, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.

Background: Lung injury due to zinc chloride smoke inhalation is very common in military personnel and leads to a high incidence of pulmonary complications and mortality. The aim of this study was to uncover the underlying mechanisms of lung injury due to zinc chloride smoke inhalation using a rat model.

Methods: Histopathology analysis of rat lungs after zinc chloride smoke inhalation was performed by using haematoxylin and eosin (H&E) and Mallory staining. Read More

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http://dx.doi.org/10.1186/s12931-019-0995-0DOI Listing
February 2019

Thoracic skeletal muscle quantification: low muscle mass is related with worse prognosis in idiopathic pulmonary fibrosis patients.

Respir Res 2019 Feb 15;20(1):35. Epub 2019 Feb 15.

Division of Pulmonary Medicine Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea.

Background: Sarcopenia can contribute to negative outcomes in patients with various lung diseases. However, whether sarcopenia affects prognosis in patients with idiopathic pulmonary fibrosis (IPF) has not been reported. Simple measures of muscle mass, derived from chest computed tomography (CT), are increasingly being used to identify patients with sarcopenia. Read More

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http://dx.doi.org/10.1186/s12931-019-1001-6DOI Listing
February 2019
1 Read

Second-hand smoke exposure in adulthood and lower respiratory health during 20 year follow up in the European Community Respiratory Health Survey.

Respir Res 2019 Feb 14;20(1):33. Epub 2019 Feb 14.

Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.

Background: Early life exposure to tobacco smoke has been extensively studied but the role of second-hand smoke (SHS) for new-onset respiratory symptoms and lung function decline in adulthood has not been widely investigated in longitudinal studies. Our aim is to investigate the associations of exposure to SHS in adults with respiratory symptoms, respiratory conditions and lung function over 20 years.

Methods: We used information from 3011 adults from 26 centres in 12 countries who participated in the European Community Respiratory Health Surveys I-III and were never or former smokers at all three surveys. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-019-0996-zDOI Listing
February 2019
4 Reads

Persistent exercise limitation after successful pulmonary endoarterectomy: frequency and determinants.

Respir Res 2019 Feb 14;20(1):34. Epub 2019 Feb 14.

Division of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Viale Golgi 19, 27100, Pavia, Italy.

Background: After successful pulmonary endoarterectomy (PEA), patients may still suffer from exercise limitation, despite normal pulmonary vascular resistance. We sought to assess the proportion of these patients after the extension of PEA to frail patients, and the determinants of exercise limitation.

Methods: Out of 553 patients treated with PEA from 2008 to 2016 at our institution, a cohort of 261 patients was followed up at 12 months. Read More

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http://dx.doi.org/10.1186/s12931-019-1002-5DOI Listing
February 2019
1 Read

Desmin and dystrophin abnormalities in upper airway muscles of snorers and patients with sleep apnea.

Respir Res 2019 Feb 14;20(1):31. Epub 2019 Feb 14.

Department of Integrative Medical Biology, Laboratory of Muscle Biology, Umeå University, SE-901 87, Umeå, Sweden.

Background: The pathophysiology of obstruction and swallowing dysfunction in snores and sleep apnea patients remains unclear. Neuropathy and to some extent myopathy have been suggested as contributing causes. Recently we reported an absence and an abnormal isoform of two cytoskeletal proteins, desmin, and dystrophin, in upper airway muscles of healthy humans. Read More

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http://dx.doi.org/10.1186/s12931-019-0999-9DOI Listing
February 2019

Is cellular senescence involved in cystic fibrosis?

Respir Res 2019 Feb 14;20(1):32. Epub 2019 Feb 14.

Cystic Fibrosis Center, Azienda Ospedaliera Universitaria Ospedali Riuniti, 60121, Ancona, Italy.

Pulmonary disease is the main cause of the morbidity and mortality of patients affected by cystic fibrosis (CF). The lung pathology is dominated by excessive recruitment of neutrophils followed by an exaggerated inflammatory process that has also been reported to occur in the absence of apparent pathogenic infections. Airway surface dehydration and mucus accumulation are the driving forces of this process. Read More

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http://dx.doi.org/10.1186/s12931-019-0993-2DOI Listing
February 2019
1 Read

Effect of COPD severity and comorbidities on the result of the PHQ-9 tool for the diagnosis of depression: results from the COSYCONET cohort study.

Respir Res 2019 Feb 11;20(1):30. Epub 2019 Feb 11.

Department of Internal Medicine V, University of Munich (LMU), Ziemssenstr. 1, 80336, Munich, Germany.

The diagnosis of depression, a frequent comorbidity of chronic obstructive pulmonary disease (COPD), is often supported by questionnaires, such as the Patient Health Questionnaire 9 (PHQ-9). It is unknown to which extent its single questions are affected by the clinical characteristics of COPD patients.We addressed this question in 2255 GOLD grade 1-4 patients from the COSYCONET (COPD and Systemic Consequences - Comorbidities Network) COPD cohort. Read More

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http://dx.doi.org/10.1186/s12931-019-0997-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371561PMC
February 2019
2 Reads

What links ventilator driving pressure with survival in the acute respiratory distress syndrome? A computational study.

Respir Res 2019 Feb 11;20(1):29. Epub 2019 Feb 11.

School of Engineering, University of Warwick, Coventry, UK.

Background: Recent analyses of patient data in acute respiratory distress syndrome (ARDS) showed that a lower ventilator driving pressure was associated with reduced relative risk of mortality. These findings await full validation in prospective clinical trials.

Methods: To investigate the association between driving pressures and ventilator induced lung injury (VILI), we calibrated a high fidelity computational simulator of cardiopulmonary pathophysiology against a clinical dataset, capturing the responses to changes in mechanical ventilation of 25 adult ARDS patients. Read More

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http://dx.doi.org/10.1186/s12931-019-0990-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371576PMC
February 2019
1 Read

BAMBI regulates macrophages inducing the differentiation of Treg through the TGF-β pathway in chronic obstructive pulmonary disease.

Respir Res 2019 Feb 6;20(1):26. Epub 2019 Feb 6.

Department of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China.

Background: Chronic obstructive pulmonary disease (COPD) is characterized by continuous flow limitation and the immune system including macrophages and regulatory T lymphocytes (Tregs) is involved in COPD pathogenesis. In our previous study, we investigated that TGF-β/BAMBI pathway was associated with COPD by regulating the balance of Th17/Treg. However, the role of bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI), a pseudoreceptor of TGF-β signalling pathway, in regulating the immune system of COPD patients has not been fully studied. Read More

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http://dx.doi.org/10.1186/s12931-019-0988-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364453PMC
February 2019

Ethyl pyruvate reduces organic dust-induced airway inflammation by targeting HMGB1-RAGE signaling.

Respir Res 2019 Feb 6;20(1):27. Epub 2019 Feb 6.

Department of Biomedical Sciences, 2008 Vet Med Building, Iowa State University, Ames, IA, USA.

Background: Animal production workers are persistently exposed to organic dust and can suffer from a variety of respiratory disease symptoms and annual decline in lung function. The role of high mobility group box-1 (HMGB1) in inflammatory airway diseases is emerging. Hence, we tested a hypothesis that organic dust exposure of airway epithelial cells induces nucleocytoplasmic translocation of HMGB1 and blocking this translocation dampens organic dust-induced lung inflammation. Read More

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http://dx.doi.org/10.1186/s12931-019-0992-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364446PMC
February 2019
1 Read

Porcine vs bovine surfactant therapy for preterm neonates with RDS: systematic review with biological plausibility and pragmatic meta-analysis of respiratory outcomes.

Respir Res 2019 Feb 6;20(1):28. Epub 2019 Feb 6.

Division of Pediatrics and Neonatal Critical Care, Medical Center "A. Béclère", South Paris University Hospitals, Assistance Publique-Hôpitaux de Paris (APHP) , Paris, France.

Background: Bovine surfactants are known to be clinically equivalent but it is unclear if porcine or bovine surfactants at their licensed dose should be preferred to treat respiratory distress syndrome in preterm neonates.

Methods: We performed a comprehensive review of biochemical and pharmacological features of surfactants to understand the biological plausibility of any clinical effect. We then performed a pragmatic meta-analysis comparing internationally marketed porcine and bovine surfactants for mortality and respiratory outcomes. Read More

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http://dx.doi.org/10.1186/s12931-019-0979-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366095PMC
February 2019
1 Read

Transcriptome analysis reveals the role of the PCP pathway in fipronil and endotoxin-induced lung damage.

Respir Res 2019 Feb 1;20(1):24. Epub 2019 Feb 1.

Department of Animal Biotechnology, School of Animal Biotechnology, Guru Angad Dev Veterinary and Animals Sciences University, Ludhiana, Punjab, 141004, India.

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-019-0986-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359862PMC
February 2019
1 Read

Clinical role, safety and diagnostic accuracy of percutaneous transthoracic needle biopsy in the evaluation of pulmonary consolidation.

Respir Res 2019 Jan 31;20(1):23. Epub 2019 Jan 31.

Division of Thoracic Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA.

Background: To determine the clinical role, safety, and diagnostic accuracy of percutaneous transthoracic needle biopsy in the evaluation of pulmonary consolidation.

Methods: A retrospective review of all computed tomography (CT)-guided percutaneous transthoracic needle biopsies (PTNB) at a tertiary care hospital over a 4-year period was performed to identify all cases of PTNB performed for pulmonary consolidation. For each case, CT Chest images were reviewed by two thoracic radiologists. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-019-0982-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357395PMC
January 2019
8 Reads

Scored minor criteria for severe community-acquired pneumonia predicted better.

Respir Res 2019 Jan 31;20(1):22. Epub 2019 Jan 31.

Guangzhou Institute of Respiratory Diseases (State Key Laboratory of Respiratory Diseases), First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, Guangdong, China.

Background: Infectious Disease Society of America/American Thoracic Society (IDSA/ATS) minor criteria for severe community-acquired pneumonia (CAP) are of unequal weight in predicting mortality, but the major problem associated with IDSA/ATS minor criteria might be a lack of consideration of weight in prediction in clinical practice. Would awarding different points to the presences of the minor criteria improve the accuracy of the scoring system? It is warranted to explore this intriguing hypothesis.

Methods: A total of 1230 CAP patients were recruited to a retrospective cohort study. Read More

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http://dx.doi.org/10.1186/s12931-019-0991-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357403PMC
January 2019
1 Read

Maternal high fat diet compromises survival and modulates lung development of offspring, and impairs lung function of dams (female mice).

Respir Res 2019 Jan 30;20(1):21. Epub 2019 Jan 30.

Telethon Kids Institute, University of Western Australia, Northern Entrance Perth Children's Hospital, 15 Hospital Ave, Nedlands, Western Australia, 6009, Australia.

Background: Epidemiological studies have identified strong relationships between maternal obesity and offspring respiratory dysfunction; however, the causal direction is not known. We tested whether maternal obesity alters respiratory function of offspring in early life.

Methods: Female C57Bl/6 J mice were fed a high or low fat diet prior to and during two rounds of mating and resulting pregnancies with offspring lung function assessed at 2 weeks of age. Read More

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http://dx.doi.org/10.1186/s12931-019-0976-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354360PMC
January 2019

NLRP3 deletion inhibits inflammation-driven mouse lung tumorigenesis induced by benzo(a)pyrene and lipopolysaccharide.

Respir Res 2019 Jan 29;20(1):20. Epub 2019 Jan 29.

Department of Toxicology, College of Public Health, Zhengzhou University, No.100 Kexue Avenue, Zhengzhou, 450001, Henan province, China.

Background: Inflammatory micro-environment has been proposed to play a critical role in lung tumorigenesis. NLRP3 is known as an intracellular receptor involving inflammation and has been reported which is increasingly associated with tumor development, but the role in inflammation-driven lung cancer has not been fully clarified. In this study, we investigated whether lipopolysaccharide (LPS)-induced pulmonary inflammation could contribute to lung tumorigenesis induced by benzo(a)pyrene [B(a)p] in C57BL/6J mice and the role of NLRP3 in the pathogenesis. Read More

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http://dx.doi.org/10.1186/s12931-019-0983-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352353PMC
January 2019
1 Read

Association of plasma soluble CD14 level with asthma severity in adults: a case control study in China.

Respir Res 2019 Jan 28;20(1):19. Epub 2019 Jan 28.

Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, Hubei, China.

Background: Soluble CD14 (sCD14) shedding from CD14 could regulate T lymphocyte activation and function, which has implicated in the pathogenesis of bronchial asthma. The level of sCD14 expression is obviously increased in asthmatic patients during acute asthma attacks. The objective of this study was to investigate the association between plasma sCD14 level and asthma severity in adults. Read More

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http://dx.doi.org/10.1186/s12931-019-0987-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348646PMC
January 2019
2 Reads

Effectiveness of long-term using statins in COPD - a network meta-analysis.

Respir Res 2019 Jan 23;20(1):17. Epub 2019 Jan 23.

Lanzhou University, Basic Medical College, Lanzhou, Gansu, 730000, People's Republic of China.

Objectives: To evaluate the effectiveness of long-term treatment of statins for chronic obstructive pulmonary disease (COPD), and to answer which one is better.

Methods: General meta-analysis was performed to produce polled estimates of the effect of mortality, inflammatory factors, and lung function index in COPD patients by the search of PubMed, Web of Science, Embase, and China National Knowledge Infrastructure for eligible studies. A network meta-analysis was performed to synthetically compare the effectiveness of using different statins in COPD patients. Read More

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http://dx.doi.org/10.1186/s12931-019-0984-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343315PMC
January 2019
1 Read

Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation.

Respir Res 2019 Jan 21;20(1):15. Epub 2019 Jan 21.

Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Background: The acute respiratory distress syndrome (ARDS) is characterized by the acute onset of hypoxemia and bilateral lung infiltrates in response to an inciting event, and is associated with high morbidity and mortality. Patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are at increased risk for ARDS. We hypothesized that HSCT patients with ARDS would have a unique transcriptomic profile identifiable in peripheral blood compared to those that did not undergo HSCT. Read More

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http://dx.doi.org/10.1186/s12931-019-0981-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341764PMC
January 2019
3 Reads

Effect of pirfenidone on lung function decline and survival: 5-yr experience from a real-life IPF cohort from the Czech EMPIRE registry.

Respir Res 2019 Jan 21;20(1):16. Epub 2019 Jan 21.

Department of Respiratory Medicine, 1st Faculty of Medicine Charles University in Prague, Thomayer Hospital, Prague, Czech Republic.

Introduction: Pirfenidone, an antifibrotic drug, slows-down the disease progression in idiopathic pulmonary fibrosis (IPF) over 12 months, however limited data on the decline of lung function and overall survival (OS) in real-world cohorts on longer follow-up exists.

Patients/methods: Of the enrolled Czech IPF patients (n = 841) from an EMPIRE registry, 383 (45.5%) received pirfenidone, 218 (25. Read More

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http://dx.doi.org/10.1186/s12931-019-0977-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341650PMC
January 2019
1 Read

Interstitial lung disease associated with systemic sclerosis (SSc-ILD).

Respir Res 2019 Jan 18;20(1):13. Epub 2019 Jan 18.

National Jewish Health, 1400 Jackson Street, Denver, CO, 80206, USA.

Background: Systemic sclerosis (SSc) is a rare connective tissue disease with a heterogeneous clinical course. Interstitial lung disease (ILD) is a common manifestation of SSc and a leading cause of death.

Main Body: All patients newly diagnosed with SSc should receive a comprehensive clinical evaluation, including assessment of respiratory symptoms, a high-resolution computed tomography (HRCT) scan of the chest, and pulmonary function tests. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-019-0980-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339436PMC
January 2019
4 Reads

Modulation of blood inflammatory markers by benralizumab in patients with eosinophilic airway diseases.

Respir Res 2019 Jan 18;20(1):14. Epub 2019 Jan 18.

MedImmune LLC, One MedImmune Way, #4552B, Gaithersburg, MD, USA.

Background: Benralizumab, a humanized, afucosylated, monoclonal antibody that targets interleukin-5 receptor α, depletes eosinophils and basophils by enhanced antibody-dependent cell-mediated cytotoxicity. It demonstrated efficacy for patients with moderate to severe asthma and, in a Phase IIa trial, for chronic obstructive pulmonary disease (COPD) with eosinophilic inflammation. We investigated effects of benralizumab 100 mg every 8 weeks (first three doses every 4 weeks) subcutaneous on blood inflammatory markers through proteomic and gene-expression analyses collected during two Phase II studies of patients with eosinophilic asthma and eosinophilic COPD. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-018-0968-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339432PMC
January 2019
3 Reads

Continuous exercise induces airway epithelium damage while a matched-intensity and volume intermittent exercise does not.

Respir Res 2019 Jan 17;20(1):12. Epub 2019 Jan 17.

URePSSS, Unité de Recherche Pluridisciplinaire Sport, Santé, Société, Lille, France.

Background: While continuous exercise (CE) induces greater ventilation ([Formula: see text]) when compared to intermittent exercise (IE), little is known of the consequences on airway damage. Our aim was to investigate markers of epithelial cell damage - i.e. Read More

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http://dx.doi.org/10.1186/s12931-019-0978-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337858PMC
January 2019

Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells.

Respir Res 2019 Jan 17;20(1):11. Epub 2019 Jan 17.

Department of Life Science and Technology, Tokyo Institute of Technology, 4259-B13 Nagatsuta-cho, Midori-ku, Yokohama, 226-8501, Japan.

Background: Adhesion G-protein coupled receptor F5 (ADGRF5) was recently identified as an essential regulator of pulmonary surfactant homeostasis in alveolar type II cells. We previously showed that in addition to abnormal surfactant accumulation, Adgrf5-deficient (Adgrf5) mice exhibit emphysema-like signs, suggesting a possible role for ADGRF5 in immune regulation. Here, we extended the phenotypic analysis of Adgrf5 mice to help understand its biological role in the lung, and especially in immune regulation. Read More

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http://dx.doi.org/10.1186/s12931-019-0973-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337809PMC
January 2019
2 Reads

Absence of early metabolic response assessed by 18F-FDG PET/CT after initiation of antifibrotic drugs in IPF patients.

Respir Res 2019 Jan 15;20(1):10. Epub 2019 Jan 15.

Department of Nuclear Medicine, Erasme University Hospital, Université libre de Bruxelles (ULB), route de Lennik 808, 1070, Brussels, Belgium.

Background: Idiopathic pulmonary fibrosis (IPF) is characterized by a progressive and irreversible respiratory failure. Non-invasive markers of disease activity are essential for prognosis and evaluation of early response to anti-fibrotic treatments.

Objectives: The aims of this study were to determine whether fluorodeoxyglucose ([18F]-FDG) lung uptake is reduced after initiation of pirfenidone or nintedanib and to assess its possible use as a prognostic factor. Read More

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http://dx.doi.org/10.1186/s12931-019-0974-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334423PMC
January 2019
4 Reads

Phospholipase Cε plays a crucial role in neutrophilic inflammation accompanying acute lung injury through augmentation of CXC chemokine production from alveolar epithelial cells.

Respir Res 2019 Jan 11;20(1). Epub 2019 Jan 11.

Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Background: We have shown that phospholipase Cε (PLCε), an effector of Ras and Rap1 small GTPases, plays pivotal roles in inflammation and inflammation-associated carcinogenesis by augmenting proinflammatory cytokine production from epithelial cells of various organs. The purpose of this study is to analyze its role in neutrophilic alveolar inflammation accompanying acute lung injury (ALI), focusing on that in alveolar epithelial cells (AECs), which are known to make a major contribution to the pathogenesis of ALI.

Methods: We examine the effect of the PLCε genotypes on the development of ALI induced by intratracheal administration of lipopolysaccharide (LPS) to PLCε wild-type (PLCε) and knockout (PLCε) mice. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-019-0975-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330467PMC
January 2019
4 Reads

Exhaled particles and small airways.

Respir Res 2019 Jan 11;20(1). Epub 2019 Jan 11.

Unit of Occupational and Environmental Medicine, Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Originally, studies on exhaled droplets explored properties of airborne transmission of infectious diseases. More recently, the interest focuses on properties of exhaled droplets as biomarkers, enabled by the development of technical equipment and methods for chemical analysis. Because exhaled droplets contain nonvolatile substances, particles is the physical designation. Read More

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http://dx.doi.org/10.1186/s12931-019-0970-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330423PMC
January 2019
2 Reads

Breath biomarkers in idiopathic pulmonary fibrosis: a systematic review.

Respir Res 2019 Jan 11;20(1). Epub 2019 Jan 11.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Background: Exhaled biomarkers may be related to disease processes in idiopathic pulmonary fibrosis (IPF) however their clinical role remains unclear. We performed a systematic review to investigate whether breath biomarkers discriminate between patients with IPF and healthy controls. We also assessed correlation with lung function, ability to distinguish diagnostic subgroups and change in response to treatment. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-019-0971-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329167PMC
January 2019
6 Reads

Treatment response to indacaterol/glycopyrronium versus salmeterol/fluticasone in exacerbating COPD patients by gender: a post-hoc analysis in the FLAME study.

Respir Res 2019 Jan 8;20(1). Epub 2019 Jan 8.

Respiratory Medicine Department, University of Ioannina Medical School, Ioannina, Greece.

Background: The burden of chronic obstructive lung disease (COPD) is increasing in women, with recent evidence suggesting gender differences in disease characteristics and potentially in treatment outcomes.

Methods: FLAME was a 52-week randomized controlled trial in patients with severe-to-very-severe COPD and a history of exacerbations. In this post-hoc analysis, gender-based baseline differences and treatment outcomes between indacaterol/glycopyrronium 110/50 μg once daily (IND/GLY) and salmeterol/fluticasone 50/500 twice daily (SFC) were assessed in terms of rate of exacerbations, time-to-first exacerbation, lung function, health status, and rescue medication use. Read More

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http://dx.doi.org/10.1186/s12931-019-0972-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325763PMC
January 2019
1 Read

Do sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis.

Respir Res 2019 Jan 8;20(1). Epub 2019 Jan 8.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Background: Previous studies have identified lung, sputum or blood transcriptomic biomarkers associated with the severity of airflow limitation in COPD. Yet, it is not clear whether the lung pathobiology is mirrored by these surrogate tissues. The aim of this study was to explore this question. Read More

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http://dx.doi.org/10.1186/s12931-018-0965-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325784PMC
January 2019
1 Read

Gasometric gradients between blood obtained from the pulmonary artery wedge and pulmonary artery positions in pulmonary arterial hypertension.

Respir Res 2019 Jan 8;20(1). Epub 2019 Jan 8.

Department of Pulmonary, Allergy and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue A-90, Cleveland, OH, 44195, USA.

Introduction: Little is known on the pulmonary gradients of oxyhemoglobin, carboxyhemoglobin and methemoglobin in pulmonary arterial hypertension (PAH). We sought to determine these gradients in group 1 PAH and assess their association with disease severity and survival.

Methods: During right heart catheterization (RHC) we obtained blood from pulmonary artery (PA) and pulmonary artery wedge (PAW) positions and used co-oximetry to test their gasometric differences. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-018-0969-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325872PMC
January 2019
5 Reads

Circular RNAs: a rising star in respiratory diseases.

Respir Res 2019 Jan 5;20(1). Epub 2019 Jan 5.

Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.

Circular RNAs (CircRNAs), as a new class of non-coding RNA molecules that, unlike linear RNAs, have covalently closed loop structures from the ligation of exons, introns, or both. CircRNAs are widely expressed in various organisms in a specie-, tissue-, disease- and developmental stage-specific manner, and have been demonstrated to play a vital role in the pathogenesis and progression of human diseases. An increasing number of recent studies has revealed that circRNAs are intensively associated with different respiratory diseases, including lung cancer, acute respiratory distress syndrome, pulmonary hypertension, pulmonary tuberculosis, and silicosis. Read More

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http://dx.doi.org/10.1186/s12931-018-0962-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321672PMC
January 2019
6 Reads

Galectin-3 enhances monocyte-derived macrophage efferocytosis of apoptotic granulocytes in asthma.

Respir Res 2019 Jan 3;20(1). Epub 2019 Jan 3.

Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, NSW, Australia.

Background: Galectin-3 is a 32 kDa protein secreted by macrophages involved in processes such as cell activation, chemotaxis and phagocytosis. Galectin-3 has previously been shown to improve the ability of airway macrophages to ingest apoptotic cells (efferocytosis) in chronic obstructive pulmonary disease (COPD) and may be of interest in non-eosinophilic asthma (NEA) which is also characterised by impaired efferocytosis. It was hypothesised that the addition of exogenous galectin-3 to monocyte-derived macrophages (MDMs) derived from donors with NEA would enhance their ability to engulf apoptotic granulocytes. Read More

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http://dx.doi.org/10.1186/s12931-018-0967-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318889PMC
January 2019
4 Reads

A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation.

Respir Res 2019 Jan 3;20(1). Epub 2019 Jan 3.

Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.

Background: Retinoid X receptors (RXRs) are members of the nuclear receptor (NR) superfamily that mediate signalling by 9-cis retinoic acid, a vitamin A derivative. RXRs play key roles not only as homodimers but also as heterodimeric partners, e.g. Read More

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http://dx.doi.org/10.1186/s12931-018-0963-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318915PMC
January 2019
10 Reads

Investigating the mechanism by which SMAD3 induces PAX6 transcription to promote the development of non-small cell lung cancer.

Respir Res 2018 Dec 29;19(1):262. Epub 2018 Dec 29.

Department of Medical Oncology, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Shushan District, Hefei, 230022, Anhui, China.

Background: This study investigated the function of SMAD3 (SMAD family member 3) in regulating PAX6 (paired box 6) in non-small cell lung cancer.

Methods: First, qRT-PCR was employed to detect SMAD3 expression in cancer tissues along with normal tissues and four cell lines, including BEAS-2B, H125, HCC827 and A549 cells. SMAD3 was knocked down by small interference RNA (siRNA), and then its expression was determined via qRT-PCR and Western blot analysis. Read More

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http://dx.doi.org/10.1186/s12931-018-0948-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311080PMC
December 2018

Clinical variables predicting the risk of a hospital stay for longer than 7 days in patients with severe acute exacerbations of chronic obstructive pulmonary disease: a prospective study.

Respir Res 2018 Dec 27;19(1):261. Epub 2018 Dec 27.

Pneumology Department, Clinic Institute of Thorax (ICT), Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Ciber de Enfermedades Respiratorias (CIBERES), Villarroel 170, 08036, Barcelona, Spain.

Background: Chronic obstructive pulmonary disease (COPD) patients may experience an acute exacerbation (AECOPD) that requires hospitalisation. The length of hospital stay (LHS) has a great economic impact on the health-care system. Knowing the predictors of prolonged LHS could help to identify possible interventions. Read More

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http://dx.doi.org/10.1186/s12931-018-0951-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307152PMC
December 2018
1 Read

Impact of Mycobacterium tuberculosis complex lineages as a determinant of disease phenotypes from an immigrant rich moderate tuberculosis burden country.

Respir Res 2018 Dec 27;19(1):259. Epub 2018 Dec 27.

Department of Infection and Immunity, MBC-03, King Faisal Specialist Hospital and Research Centre, Post Box # 3354, Riyadh, 11211, Saudi Arabia.

Background: Growing evidences suggested that the Mycobacterium tuberculosis complex (MTBC) lineages can determine the clinical outcome of pulmonary and extra-pulmonary tuberculosis. However, limited data only available revealing such association of bacterial genotypes and clinical phenotypes from immigrant rich countries.

Methods: A multicenter study has been carried out on a collection of 2092 (1003 extrapulmonary and 1089 pulmonary) MTBC isolates. Read More

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http://dx.doi.org/10.1186/s12931-018-0966-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307224PMC
December 2018

Healthier without healthcare? The paradox of the common cold.

Respir Res 2018 Dec 27;19(1):260. Epub 2018 Dec 27.

Dipl.-Biologe, Fachvirologe GfV Institut für Pathologie, Kliniken der Stadt Köln gGmbH, Klinikum der Privaten Universität Witten/Herdecke, Ostmerheimer Str. 200, D-51109, Cologne, Germany.

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http://dx.doi.org/10.1186/s12931-018-0964-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307177PMC
December 2018
1 Read

Right ventricular size and function under riociguat in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (the RIVER study).

Respir Res 2018 Dec 19;19(1):258. Epub 2018 Dec 19.

Centre for Pulmonary Hypertension, Thoraxklinik at Heidelberg University Hospital, Röntgenstraße 1, 69126, Heidelberg, Germany.

Background: Riociguat is a soluble guanylate cyclase stimulator approved for pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTPEH). The objective of this study was to evaluate right heart size and function assessed by echocardiography during long term treatment with riociguat.

Methods: Patients who started riociguat treatment (1. Read More

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http://dx.doi.org/10.1186/s12931-018-0957-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299931PMC
December 2018
1 Read

Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort.

Respir Res 2018 Dec 18;19(1):257. Epub 2018 Dec 18.

Division of Pulmonary, Allergy and Critical Care Medicine and Lung Health Center, University of Alabama at Birmingham, THT 422, 1720, 2nd Avenue South, Birmingham, AL, 35294, USA.

Background: Chronic obstructive pulmonary disease (COPD) is associated with a two-to-five fold increase in the risk of coronary artery disease independent of shared risk factors. This association is hypothesized to be mediated by systemic inflammation but this link has not been established.

Methods: We included 300 participants enrolled in the SPIROMICS cohort, 75 each of lifetime non-smokers, smokers without airflow obstruction, mild-moderate COPD, and severe-very severe COPD. Read More

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http://dx.doi.org/10.1186/s12931-018-0946-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299495PMC
December 2018
4 Reads

Predictors of clinical response to extrafine and non-extrafine particle inhaled corticosteroids in smokers and ex-smokers with asthma.

Respir Res 2018 Dec 18;19(1):256. Epub 2018 Dec 18.

Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, PO Box 30.0001, 9700, RB, Groningen, The Netherlands.

We performed a post-hoc analysis of the OLiVIA-study investigating whether current and ex-smoking asthmatics with small airways dysfunction (SAD) show a better response in airway hyperresponsiveness (AHR) to small particle adenosine after treatment with extrafine compared to non-extrafine particle inhaled corticosteroids (ICS), and to investigate which clinical parameters predict a favorable response to both treatments. We show that smoking and ex-smoking asthmatics with and without SAD have a similar treatment response with either extrafine or non-extrafine particle ICS. We also found that lower blood neutrophils are associated with a smaller ICS-response in smokers and ex-smokers with asthma, independent from the level of blood eosinophils. Read More

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http://dx.doi.org/10.1186/s12931-018-0961-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299530PMC
December 2018

Pulmonary aspiration in preschool children with cystic fibrosis.

Respir Res 2018 Dec 17;19(1):255. Epub 2018 Dec 17.

National Children's Research Centre, Crumlin, Dublin 12, Ireland.

Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin was measured in Broncho-alveolar lavage (BAL) fluid collected from clinically stable preschool children with CF and controls. Read More

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http://dx.doi.org/10.1186/s12931-018-0954-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296125PMC
December 2018
1 Read

Effects of smoking on the lower respiratory tract microbiome in mice.

Respir Res 2018 Dec 14;19(1):253. Epub 2018 Dec 14.

The Center of Experimental Teaching Management, Chongqing Medical University, Chongqing, 401331, China.

Background: Recent studies break with traditional opinion that the lower respiratory tract is sterile, and increasingly focus on the lung microbiome and disease. Smoking, as an important etiology of inflammatory lung disease, was considered as a factor influencing lung microbiome variations in our study, and we aimed to study the effect of smoking on inflammation and microbial diversity and community.

Methods: Forty male mice were selected and randomly divided into a smoking and a non-smoking group. Read More

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http://dx.doi.org/10.1186/s12931-018-0959-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295055PMC
December 2018
16 Reads

LncRNA H19 promotes the proliferation of pulmonary artery smooth muscle cells through ATR via sponging let-7b in monocrotaline-induced pulmonary arterial hypertension.

Respir Res 2018 Dec 14;19(1):254. Epub 2018 Dec 14.

Department of Respiratory Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, No. 3 Qingchun Road East, Zhejiang, Hangzhou, China.

Background: Pulmonary arterial hypertension (PAH) is related to inflammation, and the lncRNA H19 is associated with inflammation. However, whether PDGF-BB-H19-let-7b-ATR axis contributes to the pathogenesis of PAH has not been thoroughly elucidated to date. This study investigated the role of H19 in PAH and its related mechanism. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-018-0956-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295077PMC
December 2018
9 Reads

Spirometric changes during exacerbations of COPD: a post hoc analysis of the WISDOM trial.

Respir Res 2018 Dec 13;19(1):251. Epub 2018 Dec 13.

Institute of Ageing and Chronic Disease, Clinical Science Centre, University Hospital Aintree, Liverpool, UK.

Background: Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with loss of lung function and poor outcomes for patients. However, there are limited data on the time course of changes in forced expiratory volume in 1 s (FEV) preceding the first reported symptom and after the start of an exacerbation.

Methods: WISDOM was a multinational, randomized, double-blind, active-controlled, 52-week study in patients with severe-to-very severe COPD. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-018-0944-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293570PMC
December 2018
17 Reads