287,862 results match your criteria Respiratory Physiology & Neurobiology[Journal]


Role of DNA hypomethylation in lateral habenular nucleus in the development of depressive-like behavior in rats.

J Affect Disord 2019 Mar 22;252:373-381. Epub 2019 Mar 22.

Department of Physiology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, China. Electronic address:

Background: Lateral habenula nucleus (LHb) has recently been noted for its role in stress-induced depressive disorder. Yet little is known about the mechanisms by which external stimuli or depression induces pathological alteration in the LHb.

Methods: Chronic unpredictable mild stress (CUMS) was employed to model depressive-like behaviors in adult rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183242
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http://dx.doi.org/10.1016/j.jad.2019.03.062DOI Listing
March 2019
1 Read

Respiratory Physiology for the Anesthesiologist.

Anesthesiology 2019 Apr 12. Epub 2019 Apr 12.

From the Department of Anesthesiology and Perioperative Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts (L.B.) the Department of Emergency, Anesthesia and Critical Care, Foundation IRCCS Ospedale Maggiore Policlinico, and Department of Surgical Pathophysiology and Transplantation, University of Milan, Milan, Italy (A.P.).

Respiratory function is fundamental in the practice of anesthesia. Knowledge of basic physiologic principles of respiration assists in the proper implementation of daily actions of induction and maintenance of general anesthesia, delivery of mechanical ventilation, discontinuation of mechanical and pharmacologic support, and return to the preoperative state. The current work provides a review of classic physiology and emphasizes features important to the anesthesiologist. Read More

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http://dx.doi.org/10.1097/ALN.0000000000002666DOI Listing

Wearable Sensors Reveal Menses-Driven Changes in Physiology and Enable Prediction of the Fertile Window: Observational Study.

J Med Internet Res 2019 Apr 18;21(4):e13404. Epub 2019 Apr 18.

Department of Reproductive Endocrinology, University Hospital, Zurich, Switzerland.

Background: Previous research examining physiological changes across the menstrual cycle has considered biological responses to shifting hormones in isolation. Clinical studies, for example, have shown that women's nightly basal body temperature increases from 0.28 to 0. Read More

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http://www.jmir.org/2019/4/e13404/
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http://dx.doi.org/10.2196/13404DOI Listing
April 2019
1 Read

Impact of slow breathing on the blood pressure and subarachnoid space width oscillations in humans.

Sci Rep 2019 Apr 17;9(1):6232. Epub 2019 Apr 17.

Department of Human Physiology, Faculty of Health Sciences, Medical University of Gdansk, Gdansk, Poland.

The aim of the study was to assess cardiac and respiratory blood pressure (BP) and subarachnoid space (SAS) width oscillations during the resting state for slow and fast breathing and breathing against inspiratory resistance. Experiments were performed on a group of 20 healthy volunteers (8 males and 12 females; age 25.3 ± 7. Read More

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http://dx.doi.org/10.1038/s41598-019-42552-9DOI Listing

Genetic analyses of aplastic anemia and idiopathic pulmonary fibrosis patients with short telomeres, possible implication of DNA-repair genes.

Orphanet J Rare Dis 2019 Apr 17;14(1):82. Epub 2019 Apr 17.

Instituto de Investigaciones Biomedicas CSIC/UAM, IDIPaz, Arturo Duperier, 4, 28029, Madrid, Spain.

Background: Telomeres are nucleoprotein structures present at the terminal region of the chromosomes. Mutations in genes coding for proteins involved in telomere maintenance are causative of a number of disorders known as telomeropathies. The genetic origin of these diseases is heterogeneous and has not been determined for a significant proportion of patients. Read More

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http://dx.doi.org/10.1186/s13023-019-1046-0DOI Listing

The Importance of Iron Status for Young Children in Low- and Middle-Income Countries: A Narrative Review.

Pharmaceuticals (Basel) 2019 Apr 16;12(2). Epub 2019 Apr 16.

Laboratory of Human Nutrition, Institute of Food Nutrition and Health, Department of Health Sciences and Technology, ETH Zürich, CH-8092 Zürich, Switzerland.

Early childhood is characterised by high physiological iron demand to support processes including blood volume expansion, brain development and tissue growth. Iron is also required for other essential functions including the generation of effective immune responses. Adequate iron status is therefore a prerequisite for optimal child development, yet nutritional iron deficiency and inflammation-related iron restriction are widespread amongst young children in low- and middle-income countries (LMICs), meaning iron demands are frequently not met. Read More

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https://www.mdpi.com/1424-8247/12/2/59
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http://dx.doi.org/10.3390/ph12020059DOI Listing
April 2019
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Glutamate receptor plasticity in brainstem respiratory nuclei following chronic hypercapnia in goats.

Physiol Rep 2019 Apr;7(8):e14035

Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Patients that retain CO in respiratory diseases such as chronic obstructive pulmonary disease (COPD) have worse prognoses and higher mortality rates than those with equal impairment of lung function without hypercapnia. We recently characterized the time-dependent physiologic effects of chronic hypercapnia in goats, which suggested potential neuroplastic shifts in ventilatory control mechanisms. However, little is known about how chronic hypercapnia affects brainstem respiratory nuclei (BRN) that control multiple physiologic functions including breathing. Read More

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http://dx.doi.org/10.14814/phy2.14035DOI Listing

Enhancement of excitatory transmission in NTS neurons projecting to ventral medulla of rats exposed to sustained hypoxia is blunted by minocycline.

J Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14049-900, SP, Brazil.

Key Points: -Rats submitted to sustained hypoxia (SH) presents increase in arterial pressure (AP) as well as increase in glutamatergic transmission in the nucleus tractus solitarius (NTS) neurons sending projections to ventrolateral medulla (VLM). -Treatment with minocycline, a microglial inhibitor, attenuated the increase in AP in response to SH. -The increase in the amplitude of glutamatergic post-synaptic currents in the NTS-VLM neurons, induced by post-synaptic mechanisms, was blunted by minocycline treatment. Read More

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http://dx.doi.org/10.1113/JP277532DOI Listing

Two Approaches to Classifying and Quantifying Physical Resilience in Longitudinal Data.

J Gerontol A Biol Sci Med Sci 2019 Apr 17. Epub 2019 Apr 17.

Duke University, Durham, North Carolina, United States.

Background: Approaches for quantifying physical resilience in older adults have not been described.

Methods: We apply 2 conceptual approaches to defining physical resilience to existing longitudinal datasets in which outcomes are measured after an acute physical stressor. A "recovery phenotype" approach uses statistical methods to describe how quickly and completely a patient recovers. Read More

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https://academic.oup.com/biomedgerontology/advance-article/d
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http://dx.doi.org/10.1093/gerona/glz097DOI Listing
April 2019
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Evaluation of physiology knowledge loss in medical students of Ahvaz Jundishapur University of Medical Sciences.

Adv Med Educ Pract 2019 29;10:157-162. Epub 2019 Mar 29.

Physiology Research Center (PRC), Department of Physiology, School of Medicine, Medical Educational and Development Center (EDC), Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran,

Purpose: The knowledge loss or longevity of taught lessons is a major concern in medical students and all medical practitioners. This study evaluated the physiology knowledge loss in medical students in Ahvaz Jundishapur University of Medical Sciences in Iran.

Methods: A total of 265 volunteers from medical students who had previously passed the "general exam of medical basic sciences" at the end of fifth semester took a retention test (RT) to evaluate their knowledge loss of physiology. Read More

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http://dx.doi.org/10.2147/AMEP.S189029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445220PMC

The six-minute stepper test is related to muscle strength but cannot substitute for the one repetition maximum to prescribe strength training in patients with COPD.

Int J Chron Obstruct Pulmon Dis 2019 29;14:767-774. Epub 2019 Mar 29.

Normandie University, UNIROUEN, UPRES EA 3830, Rouen University Hospital, Haute Normandie Research and Biomedical Innovation, Rouen, France,

Purpose: There are many barriers to pulmonary rehabilitation, including a limited access to evaluation centers. To cope with these difficulties, field tests are often used to prescribe endurance training. As field tests are related to muscle strength, they could also be used to prescribe strength training and increase the access to pulmonary rehabilitation in rural area. Read More

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http://dx.doi.org/10.2147/COPD.S193585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445245PMC

Borneo herbal plant extracts as a natural medication for prophylaxis and treatment of and infection in tilapia ( ).

F1000Res 2018 26;7:1847. Epub 2018 Nov 26.

Department of Fisheries, Faculty of Fisheries and Marine Science, Padjajaran University, Bandung, West Java, 40600, Indonesia.

The combination of some plant extracts to prevent and treat bacterial infections is gaining momentum, because of effectiveness against certain bacteria. This study aims to describe the antibacterial and immunostimulant abilities of (BP), (SF) and (ZZ) plant extracts to treat and prevent and infection on Tilapia ( ). Tilapia (initial weight 15±2 g) were injected intramuscularly (0. Read More

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https://f1000research.com/articles/7-1847/v1
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http://dx.doi.org/10.12688/f1000research.16902.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439779PMC
November 2018
1 Read

Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep.

PLoS Genet 2019 Apr 16;15(4):e1007739. Epub 2019 Apr 16.

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States of America.

Sleep disordered breathing (SDB)-related overnight hypoxemia is associated with cardiometabolic disease and other comorbidities. Understanding the genetic bases for variations in nocturnal hypoxemia may help understand mechanisms influencing oxygenation and SDB-related mortality. We conducted genome-wide association tests across 10 cohorts and 4 populations to identify genetic variants associated with three correlated measures of overnight oxyhemoglobin saturation: average and minimum oxyhemoglobin saturation during sleep and the percent of sleep with oxyhemoglobin saturation under 90%. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007739DOI Listing

Essential Role of Visfatin in Lipopolysaccharide and Colon Ascendens Stent Peritonitis-Induced Acute Lung Injury.

Int J Mol Sci 2019 Apr 4;20(7). Epub 2019 Apr 4.

Translational Research Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Acute lung injury (ALI) is a life-threatening syndrome characterized by acute and severe hypoxemic respiratory failure. Visfatin, which is known as an obesity-related cytokine with pro-inflammatory activities, plays a role in regulation of inflammatory cytokines. The mechanisms of ALI remain unclear in critically ill patients. Read More

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http://dx.doi.org/10.3390/ijms20071678DOI Listing

Mechanism and impact of catecholamine conversion by Vibrio cholerae.

Biochim Biophys Acta Bioenerg 2019 Apr 12. Epub 2019 Apr 12.

Institute of Microbiology, University of Hohenheim, Stuttgart, Germany. Electronic address:

Bacterial pathogens are influenced by signaling molecules including the catecholamines adrenaline and noradrenaline which are host-derived hormones and neurotransmitters. Adrenaline and noradrenaline modulate growth, motility and virulence of bacteria. We show that adrenaline is converted by the pathogen Vibrio cholerae to adrenochrome in the course of respiration, and demonstrate that superoxide produced by the respiratory, Na - translocating NADH:quinone oxidoreductase (NQR) acts as electron acceptor in the oxidative conversion of adrenaline to adrenochrome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00052728193003
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http://dx.doi.org/10.1016/j.bbabio.2019.04.003DOI Listing
April 2019
2 Reads

Pneumothorax: A Rare Entity During Pregnancy.

Turk Thorac J 2019 Apr 9. Epub 2019 Apr 9.

Department of Thoracic Surgery, Ege University, School of Medicine, İzmir, Turkey.

Pneumothorax is a rarely seen condition during pregnancy, when changes in the respiratory physiology can sensitize the mother and fetus to the signs of hypoxia. Symptoms of pneumothorax, such as dyspnea, tachypnea, and chest pain, can also be attributed to pregnancy and complications with pregnancy and this can lead to misdiagnoses. The limitations in the use of diagnostic tests, such as chest X-ray and computed tomography, make treatment more difficult. Read More

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http://turkthoracj.org/eng/makale/1108/154/Full-Text
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http://dx.doi.org/10.5152/TurkThoracJ.2018.18154DOI Listing
April 2019
1 Read

Nutritional Ketoacidosis During Incremental Exercise in Healthy Athletes.

Front Physiol 2019 29;10:290. Epub 2019 Mar 29.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

Ketosis, achieved through ingestion of ketone esters, may influence endurance exercise capacity by altering substrate metabolism. However, the effects of ketone consumption on acid-base status and subsequent metabolic and respiratory compensations are poorly described. Twelve athletically trained individuals completed an incremental bicycle ergometer exercise test to exhaustion following the consumption of either a ketone ester [-3-hydroxybutyrate--1,3-butanediol] or a taste-matched control drink (bitter flavoured water) in a blinded, cross-over study. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2019.00290
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http://dx.doi.org/10.3389/fphys.2019.00290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450328PMC
March 2019
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Effects of Ongoing Feedback During a 12-Month Maintenance Walking Program on Daily Physical Activity in People with COPD.

Lung 2019 Apr 15. Epub 2019 Apr 15.

Faculty of Health Sciences, The University of Sydney, Sydney, NSW, 2006, Australia.

This multi-centred, randomised controlled trial explored the effects of adding ongoing feedback to a 12-month unsupervised maintenance walking program, on daily physical activity (PA) in people with chronic obstructive pulmonary disease. Participants were randomised to either an intervention group (IG) or a usual care group (UCG). During the maintenance program, the IG received ongoing feedback (telephone calls, biofeedback provided via pedometer and progressive goal setting) and the UCG received no feedback. Read More

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http://dx.doi.org/10.1007/s00408-019-00216-5DOI Listing

β-Hydroxy-β-methylbutyrate and its impact on skeletal muscle mass and physical function in clinical practice: a systematic review and meta-analysis.

Am J Clin Nutr 2019 Apr;109(4):1119-1132

Department of Nutritional Sciences, School of Life Course Sciences, King's College London, London, UK.

Background: Loss of skeletal muscle mass and muscle weakness are common in a variety of clinical conditions with both wasting and weakness associated with an impairment of physical function. β-Hydroxy-β-methylbutyrate (HMB) is a nutrition supplement that has been shown to favorably influence muscle protein turnover and thus potentially plays a role in ameliorating skeletal muscle wasting and weakness.

Objectives: The aim of this study was to investigate the efficacy of HMB alone, or supplements containing HMB, on skeletal muscle mass and physical function in a variety of clinical conditions characterized by loss of skeletal muscle mass and weakness. Read More

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http://dx.doi.org/10.1093/ajcn/nqy373DOI Listing

The effect of fluconazole on oral methadone in dogs.

Vet Anaesth Analg 2019 Feb 19. Epub 2019 Feb 19.

Vanderbilt University Center for Neuroscience Drug Discovery, Cool Springs Life Science Center, Nashville, TN, USA.

Objective: To determine the effects of fluconazole on oral methadone pharmacokinetics and central effects mediated by opioid receptors in dogs.

Study Design: Prospective, incomplete block.

Animals: A total of 12 healthy Beagle dogs. Read More

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http://dx.doi.org/10.1016/j.vaa.2019.02.003DOI Listing
February 2019

Effect of prehabilitation on ventilatory efficiency in non-small cell lung cancer patients: A cohort study.

J Thorac Cardiovasc Surg 2019 Feb 19. Epub 2019 Feb 19.

Department of Respiratory and Exercise Physiology and CIC-CRB 1404, Rouen University Hospital, Rouen, France.

Objective: Cardiopulmonary exercise testing (CPET) for patients awaiting lung resection for non-small cell lung cancer (NSCLC) has developed considerably in recent years. Pulmonary rehabilitation before surgery (prehabilitation) improves postoperative risk factors such as forced expiratory volume in 1 second and peak oxygen consumption (VO). Ventilatory inefficiency assessed according to the linear regression of the ratio between the increase in minute ventilation and the expired carbon dioxide flow during CPET (VE/VCO slope) >35, is a high-risk factor for postoperative complications. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2019.02.016DOI Listing
February 2019

Cystic fibrosis dyslipidaemia: A cross-sectional study.

J Cyst Fibros 2019 Apr 9. Epub 2019 Apr 9.

Poznan University of Medical Sciences, Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan, Poland. Electronic address:

Background: The interest in cystic fibrosis (CF) dyslipidaemia as a potential risk factor for cardiovascular disease is increasing with patients' survival. This study aimed to investigate CF dyslipidaemia, its clinical correlates and links to oxidized low-density lipoprotein (oxLDL), adiponectin, and apolipoprotein E (APOE).

Methods: This cross-sectional study assessed clinical characteristics of CF, as well as the serum lipid profile, oxLDL, adiponectin, and APOE. Read More

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http://dx.doi.org/10.1016/j.jcf.2019.04.001DOI Listing

Genomic characterization of Kerstersia gyiorum SWMUKG01, an isolate from a patient with respiratory infection in China.

PLoS One 2019 12;14(4):e0214686. Epub 2019 Apr 12.

Department of Pathogenic Biology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China.

Background: The Gram-negative bacterium Kerstersia gyiorum, a potential etiological agent of clinical infections, was isolated from several human patients presenting clinical symptoms. Its significance as a possible pathogen has been previously overlooked as no disease has thus far been definitively associated with this bacterium. To better understand how the organism contributes to the infectious disease, we determined the complete genomic sequence of K. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214686PLOS
April 2019
5 Reads

Novel insights into parathyroid hormone: report of The Parathyroid Day in Chronic Kidney Disease.

Clin Kidney J 2019 Apr 20;12(2):269-280. Epub 2018 Jul 20.

Division of Nephrology, Ambroise Paré University Medical Center, APHP, University of Paris Ouest (UVSQ), Boulogne Billancourt/Paris, France.

Chronic kidney disease (CKD) is often associated with a mineral and bone disorder globally described as CKD-Mineral and Bone Disease (MBD), including renal osteodystrophy, the latter ranging from high bone turnover, as in case of secondary hyperparathyroidism (SHPT), to low bone turnover. The present article summarizes the important subjects that were covered during 'The Parathyroid Day in Chronic Kidney Disease' CME course organized in Paris in September 2017. It includes the latest insights on parathyroid gland growth, parathyroid hormone (PTH) synthesis, secretion and regulation by the calcium-sensing receptor, vitamin D receptor and fibroblast growth factor 23 (FGF23)-Klotho axis, as well as on parathyroid glands imaging. Read More

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http://dx.doi.org/10.1093/ckj/sfy061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452197PMC
April 2019
2 Reads

Bok regulates mitochondrial fusion and morphology.

Cell Death Differ 2019 Apr 11. Epub 2019 Apr 11.

Department of Pharmacology, SUNY Upstate Medical University, 750 E Adams Street, Syracuse, NY, 13210, USA.

Bok (Bcl-2-related ovarian killer) is a member of the Bcl-2 protein family that governs the intrinsic apoptosis pathway, but the cellular role that Bok plays is controversial. Remarkably, endogenous Bok is constitutively bound to inositol 1,4,5-trisphosphate receptors (IPRs) and is stabilized by this interaction. Here we report that despite the strong association with IPRs, deletion of Bok expression by CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein-9 nuclease)-mediated gene editing does not alter calcium mobilization via IPRs or calcium influx into the mitochondria. Read More

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http://www.nature.com/articles/s41418-019-0327-4
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http://dx.doi.org/10.1038/s41418-019-0327-4DOI Listing
April 2019
2 Reads

Genetic Variation for Ontogenetic Shifts in Metabolism Underlies Physiological Homeostasis in .

Genetics 2019 Apr 11. Epub 2019 Apr 11.

University of Nebraska-Lincoln.

Organismal physiology emerges from metabolic pathways and subcellular structures like the mitochondria that can vary across development and among individuals. Here we tested whether genetic variation at one level of physiology can be buffered at higher biological levels of organization during development by the inherent capacity for homeostasis in physiological systems. We found that the fundamental scaling relationship between mass and metabolic rate, as well as the oxidative capacity per mitochondria, changed significantly across development in the fruit fly However, mitochondrial respiration rate was maintained at similar levels across development. Read More

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http://dx.doi.org/10.1534/genetics.119.302052DOI Listing

The dynamic adaptation of Brazilian Brahman bulls.

J Therm Biol 2019 Apr 25;81:128-136. Epub 2019 Feb 25.

Department of Zootecnia, University of Vale Acaraú, Sobral, CE, Brazil.

Heat stress is one of the most important factors that affect the performance of some Bos taurus breeds and crosses in tropical regions. The Brahman breed was developed in hot regions of the world and often has genes that confer resistance to heat stress compared to other breeds of beef cattle. The goal of this work was to evaluate the adaptive responses of Brahman bulls, based on physiological, hormonal and hair characteristics according to season. Read More

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http://dx.doi.org/10.1016/j.jtherbio.2019.02.016DOI Listing

Cardiorespiratory profiling reveals primary breathing dysfunction in Kcna1-null mice: Implications for sudden unexpected death in epilepsy.

Neurobiol Dis 2019 Apr 8;127:502-511. Epub 2019 Apr 8.

Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center Shreveport, LA 71103, USA. Electronic address:

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality, but the relative importance of underlying cardiac and respiratory mechanisms remains unclear. To illuminate the interactions between seizures, respiration, cardiac function, and sleep that contribute to SUDEP risk, here we developed a mouse epilepsy monitoring unit (EMU) to simultaneously record video, electroencephalography (EEG), electromyography (EMG), plethysmography, and electrocardiography (ECG) in a commonly used genetic model of SUDEP, the Kcna1 knockout (Kcna1) mouse. During interictal periods, Kcna1 mice exhibited an abnormal absence of post-sigh apneas and a 3-fold increase in respiratory variability. Read More

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http://dx.doi.org/10.1016/j.nbd.2019.04.006DOI Listing
April 2019
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A method for assessing mitochondrial physiology using mechanically permeabilized flight muscle of Aedes aegypti mosquitoes.

Anal Biochem 2019 Apr 8;576:33-41. Epub 2019 Apr 8.

Laboratório de Bioquímica de Resposta Ao Estresse, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal Do Rio de Janeiro, Cidade Universitária, Rio de Janeiro, RJ, Brazil; Instituto Nacional de Ciência e Tecnologia Em Entomologia Molecular (INCT-EM), Rio de Janeiro, RJ, Brazil. Electronic address:

Aedes aegypti is the most important and widespread vector of arboviruses, including dengue and zika. Insect dispersal through the flight activity is a key parameter that determines vector competence, and is energetically driven by oxidative phosphorylation in flight muscle mitochondria. Analysis of mitochondrial function is central for a better understanding of cellular metabolism, and is mostly studied using isolated organelles. Read More

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http://dx.doi.org/10.1016/j.ab.2019.04.005DOI Listing

XBP1S Regulates MUC5B in a Promoter Variant-Dependent Pathway in IPF Airway Epithelia.

Am J Respir Crit Care Med 2019 Apr 11. Epub 2019 Apr 11.

University of North Carolina, Cystic Fibrosis/Pulmonary Research and Treatment Center, Chapel Hill,, North Carolina, United States ;

Rationale: The goal was to connect elements of IPF pathogenesis, including: chronic endoplasmic reticulum stress in respiratory epithelia associated with injury/inflammation and remodeling; distal airway mucus obstruction and honeycomb cyst formation with accumulation of MUC5B; and associations between IPF risk and polymorphisms in the MUC5B promoter.

Objectives: Test whether the ER stress sensor protein ER-to-nucleus signaling 2 (ERN2) and its downstream effector, the spliced form of x-box binding protein 1 (XBP1S), regulate MUC5B expression and differentially activate the MUC5B promoter variant in respiratory epithelia.

Methods And Measurements: Primary human airway epithelia (HAE), transgenic mouse models, human IPF lung tissues, and cell lines expressing XBP1S and MUC5B promoters were used to explore relationships between the ERN2/XBP1S pathway and MUC5B. Read More

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http://dx.doi.org/10.1164/rccm.201810-1972OCDOI Listing
April 2019
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Rutin hydrate inhibits apoptosis in the brains of cadmium chloride-treated rats via preserving the mitochondrial integrity and inhibiting endoplasmic reticulum stress.

Neurol Res 2019 Apr 11:1-15. Epub 2019 Apr 11.

f Department of Medical Biochemistry , Faculty of Medicine, Mansoura University , Mansoura , Egypt.

Recent evidence has suggested that cadmium (Cd) ions-induced neurotoxicity is associated with increased oxidative stress and mitochondrial-dependent and endoplasmic reticulum (ER) stress-induced apoptosis. This study aimed to investigate if rutin hydrate (RH), a well-reported neuroprotective and an antioxidant flavonoid, can ameliorate cadmium chloride (CdCl2)-induced neurotoxicity by inhibiting the resultant ER stress. Rats were divided into 4 groups (n = 16/group) of control, control + RH (100 mg/kg), CdCl (5 mg/kg), and CdCl + RH. Read More

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https://www.tandfonline.com/doi/full/10.1080/01616412.2019.1
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http://dx.doi.org/10.1080/01616412.2019.1596206DOI Listing
April 2019
3 Reads

Effects of exercise preconditioning and HSP72 on diaphragm muscle function during mechanical ventilation.

J Cachexia Sarcopenia Muscle 2019 Apr 10. Epub 2019 Apr 10.

Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, 32611, USA.

Background: Mechanical ventilation (MV) is a life-saving measure for patients in respiratory failure. However, prolonged MV results in significant diaphragm atrophy and contractile dysfunction, a condition referred to as ventilator-induced diaphragm dysfunction (VIDD). While there are currently no clinically approved countermeasures to prevent VIDD, increased expression of heat shock protein 72 (HSP72) has been demonstrated to attenuate inactivity-induced muscle wasting. Read More

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http://dx.doi.org/10.1002/jcsm.12427DOI Listing
April 2019
1 Read
7.413 Impact Factor

Periodic breathing in healthy young adults in normobaric hypoxia equivalent to 3500 m, 4500 m, and 5500 m altitude.

Sleep Breath 2019 Apr 10. Epub 2019 Apr 10.

Dept. of Psychology and Sports Science, Hermann Buhl Institute for Hypoxia and Sleep Medicine Research, University of Innsbruck, Ghersburgstr. 9, 83043, Bad Aibling, Germany.

Purpose: The occurrence of periodic breathing (PB) at high altitude during sleep and the quality of sleep are individually different and influenced by multiple factors including sex. Although poor sleep quality at high altitude might not be directly linked to oxygen desaturations, the PB upsurge at high altitude leads to significant oscillations in oxygen saturation.

Methods: Thirty-three students were recruited. Read More

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http://link.springer.com/10.1007/s11325-019-01829-z
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http://dx.doi.org/10.1007/s11325-019-01829-zDOI Listing
April 2019
5 Reads

Methylopila carotae sp. nov., a facultative methylotroph, isolated from a root of Daucus carota L.

Antonie Van Leeuwenhoek 2019 Apr 10. Epub 2019 Apr 10.

IBPM RAS, G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms of the Russian Academy of Sciences, Federal Research Center Pushchino Center for Biological Research of the Russian Academy of Sciences, Prospect Nauki, 5, Pushchino, Moscow Region, Russia, 142290.

An aerobic facultatively methylotrophic bacterium, designated strain Das4.1, was isolated from a root of Daucus carota L. The cells of this strain were observed to be Gram-stain negative, asporogenous, non-motile short rods multiplying by binary fission. Read More

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http://dx.doi.org/10.1007/s10482-019-01263-xDOI Listing

Oxygen Availability in Respiratory Muscles During Exercise in Children Following Fontan Operation.

Front Pediatr 2019 26;7:96. Epub 2019 Mar 26.

Department of Pediatric Cardiology and Congenital Heart Defects, German Heart Centre, Munich, Germany.

As survival of previously considered as lethal congenital heart disease forms is the case in our days, issues regarding quality of life including sport and daily activities emerge. In patients with Fontan circulation, there is no pump to propel blood into the pulmonary arteries since the systemic veins are directly connected to the pulmonary arteries. The complex hemodynamics of Fontan circulation include atrial function, peripheral muscle pump, integrity of the atrioventricular valve, absence of restrictive, or obstructive pulmonary lung function. Read More

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http://dx.doi.org/10.3389/fped.2019.00096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443956PMC
March 2019
1 Read

Smooth muscle atrophy and colon pathology in SMN deficient mice.

Am J Transl Res 2019 15;11(3):1789-1799. Epub 2019 Mar 15.

Department of Physiology, University of Pennsylvania Perelman School of Medicine Philadelphia, PA.

Spinal muscular atrophy (SMA) is an autosomal recessive genetic disorder characterized by loss of motor neurons in the ventral horn of the spinal cord. Clinical features such as progressively lethal respiratory weakness and associated muscle wasting have been extensively studied but less attention has been given to gastrointestinal (GI) dysfunction, which is common symptomatology in SMA patients with 43% constipation, 15% abdominal pain, and 14% meteorism. In the current study, the PrP92-SMN mouse model of SMA was utilized, to complement previous studies in which cells of the Enteric Nervous system (ENS) were susceptible to Smn (survival motor neuron) deficiency and could possibly be the basis of the observed GI symptoms. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456546PMC
March 2019
3 Reads

First Experience with Extracorporeal Membrane Oxygenation in Iran, under Difficult Conditions.

J Tehran Heart Cent 2018 Oct;13(4):166-172

Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Extracorporeal membrane oxygenation (ECMO) provides hemodynamic and oxygenation support in critical conditions. The commencement of this modality in Iran coincided with severe economic constraints across Iran. This retrospective study was performed in Masih Daneshvari Medical Center from 2010 to 2015, during which period, sanction-related limitations in the import of equipment prompted us to integrate a Medtronic or Stöckert head pump console into a Maquet ECMO Oxygenator so as to sustain the ECMO program. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450813PMC
October 2018
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Regenerative therapy based on miRNA-302 mimics for enhancing host recovery from pneumonia caused by .

Proc Natl Acad Sci U S A 2019 Apr 10. Epub 2019 Apr 10.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

Bacterial pneumonia remains a leading cause of morbidity and mortality worldwide. A defining feature of pneumonia is lung injury, leading to protracted suffering and vulnerability long after bacterial clearance. Little is known about which cells are damaged during bacterial pneumonia and if the regenerative process can be harnessed to promote tissue repair and host recovery. Read More

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http://dx.doi.org/10.1073/pnas.1818522116DOI Listing
April 2019
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Effects of tai chi on physiology, balance and quality of life in patients with type 2 diabetes: A systematic review and meta-analysis.

J Rehabil Med 2019 Apr 10. Epub 2019 Apr 10.

Department of Epidemiology and Biostatistics, Sichuan University West China School of Public Health, 610041 Chengdu, China.

Objective: To systematically synthesize and critically evaluate evidence on the effectiveness of tai chi for patients with type 2 diabetes mellitus.

Data Sources: Seven electronic databases (Wan Fang, SinoMed, China National Knowledge Infrastructure, VIP, PubMed, Embase, and Cochrane Library) were systematically searched from their inception to March 2018.

Study Selection: Randomized controlled trials investigating the effects of tai chi on individuals with type 2 diabetes mellitus were eligible. Read More

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http://dx.doi.org/10.2340/16501977-2555DOI Listing
April 2019
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Subjective and Objective Outcomes in Patients With COPD After Pulmonary Rehabilitation - The Impact of Comorbidities.

Front Physiol 2019 22;10:286. Epub 2019 Mar 22.

Division of Pulmonology, Department of Clinical Therapeutics, School of Medicine, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with multiple systemic manifestations and comorbidities, which contribute independently to its total morbidity and mortality. Pulmonary rehabilitation is an evidence-based intervention that is indicated for COPD patients who remain symptomatic, despite optimal pharmacological therapy. Although it is well documented in pure COPD, the role of pulmonary rehabilitation is uncertain in coexisting comorbidities. Read More

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http://dx.doi.org/10.3389/fphys.2019.00286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438881PMC
March 2019
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Respiratory sinus arrhythmia is a major component of HRV in undisturbed, remotely monitored rattlesnakes, .

J Exp Biol 2019 Apr 9. Epub 2019 Apr 9.

Department of Physiological Sciences, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, Brazil

An implanted telemetry device transmitted ECG from the South American rattlesnake, held under stable conditions without restraining cables or interaction with researchers. Mean heart rate () recovered rapidly (<24h) from anaesthesia and operative procedures. This anticipated a more gradual development of heart rate variability (HRV), with instantaneous increasing during each lung ventilation cycle. Read More

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http://dx.doi.org/10.1242/jeb.197954DOI Listing

Pressure and flow properties of cannulae for extracorporeal membrane oxygenation I: return (arterial) cannulae.

Perfusion 2019 Apr;34(1_suppl):58-64

3 Working Group on Innovation and Technology, EuroElso, Newcastle upon Tyne, UK.

Adequate extracorporeal membrane oxygenation support in the adult requires cannulae permitting blood flows up to 6-8 L/minute. In accordance with Poiseuille's law, flow is proportional to the fourth power of cannula inner diameter and inversely proportional to its length. Poiseuille's law can be applied to obtain the pressure drop of an incompressible, Newtonian fluid (such as water) flowing in a cylindrical tube. Read More

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http://dx.doi.org/10.1177/0267659119830521DOI Listing
April 2019
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Pressure and flow properties of cannulae for extracorporeal membrane oxygenation II: drainage (venous) cannulae.

Perfusion 2019 Apr;34(1_suppl):65-73

3 Working Group on Innovation and Technology, EuroELSO, Newcastle upon Tyne, UK.

The use of extracorporeal life support devices such as extracorporeal membrane oxygenation in adults requires cannulation of the patient's vessels with comparatively large diameter cannulae to allow circulation of large volumes of blood (>5 L/min). The cannula diameter and length are the major determinants for extracorporeal membrane oxygenation flow. Manufacturing companies present pressure-flow charts for the cannulae; however, these tests are performed with water. Read More

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http://dx.doi.org/10.1177/0267659119830514DOI Listing
April 2019
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Differential hypoxemia during venoarterial extracorporeal membrane oxygenation.

Perfusion 2019 Apr;34(1_suppl):22-29

1 ECMO Centre Karolinska, Department of Pediatric Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden.

Venoarterial extracorporeal membrane oxygenation, indicated for severe cardio-respiratory failure, may result in anatomic regional differences in oxygen saturation. This depends on cannulation, hemodynamic state, and severity of respiratory failure. Differential hypoxemia, often discrete, may cause clinical problems in peripheral femoro-femoral venoarterial extracorporeal membrane oxygenation, when the upper body is perfused with low saturated blood from the heart and the lower body with well-oxygenated extracorporeal membrane oxygenation blood. Read More

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http://dx.doi.org/10.1177/0267659119830513DOI Listing
April 2019
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Mesenchymal stem cells may ameliorate inflammation in an ex vivo model of extracorporeal membrane oxygenation.

Perfusion 2019 Apr;34(1_suppl):15-21

1 Critical Care Research Group, The Prince Charles Hospital, The University of Queensland, Brisbane, QLD, Australia.

Introduction: Mesenchymal stem cells exhibit immunomodulatory properties which are currently being investigated as a novel treatment option for Acute Respiratory Distress Syndrome. However, the feasibility and efficacy of mesenchymal stem cell therapy in the setting of extracorporeal membrane oxygenation is poorly understood. This study aimed to characterise markers of innate immune activation in response to mesenchymal stem cells during an ex vivo simulation of extracorporeal membrane oxygenation. Read More

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http://dx.doi.org/10.1177/0267659119830857DOI Listing
April 2019
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Long-term pulmonary function and quality of life in adults after extracorporeal membrane oxygenation for respiratory failure.

Perfusion 2019 Apr;34(1_suppl):49-57

2 Department of Pediatric Anaesthesia, Intensive Care and ECMO Services, Astrid Lindgren Children's Hospital, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

Background: There is a significant long-term burden on survivors after acute respiratory distress syndrome, even 5 years after discharge. This is not well investigated in patients treated with extracorporeal membrane oxygenation. The objective of this study was to describe very-long-term (⩾3 years) disability in lung function and morphology, quality of life, mood disorders, walking capacity, and return to work status in extracorporeal membrane oxygenation survivors. Read More

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http://dx.doi.org/10.1177/0267659119830244DOI Listing