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Oncologist 2019 Apr 17. Epub 2019 Apr 17.

Sjögren's Syndrome and Salivary Gland Dysfunction Unit, National Institutes of Health, Baltimore, Maryland, USA.

Background: The objective of this study was to characterize the clinicopathologic features of sicca syndrome associated with immune checkpoint inhibitor (ICI) therapy.

Subjects, Materials, And Methods: Consecutive patients with new or worsening xerostomia in the setting of ICI treatment for benign or malignant neoplastic disease were evaluated, including labial salivary gland biopsy (LSGB).

Results: Twenty patients (14 male; median age 57 years) had metastatic melanoma ( = 10), metastatic carcinoma ( = 6), or recurrent respiratory papillomatosis ( = 4) and were being treated with avelumab ( = 8), nivolumab ( = 5), pembrolizumab ( = 4), nivolumab/ipilimumab ( = 2), and M7824, a biologic targeting programmed cell death ligand 1 (PD-L1) and transforming growth factor ß ( = 1). Read More

Laryngoscope 2019 Apr 8. Epub 2019 Apr 8.

Department of Otorhinolaryngology-Head and Neck Surgery, Nihon University School of Medicine, Tokyo, Japan.

Objective: To examine whether human papilloma virus (HPV) vaccination in combination with surgical resection could suppress recurrence for an extended period of time in patients with recurrent respiratory papillomatosis (RRP).

Methods: In a prospective case series, data of patients who received combination therapy comprising surgery and quadrivalent HPV vaccination (Gardasil; Merck & Co., West Point, PA) were collected. Read More

Antiviral Res 2019 Mar 26. Epub 2019 Mar 26.

Department of Biological Sciences, Michigan Technological University, Houghton, MI, 49931, USA. Electronic address:

Human papillomaviruses (HPVs) are the most common sexually transmitted infections. HPVs are transmitted through anogenital sex or oral sex. Anogenital transmission/infection is associated with anogenital cancers and genital warts while oral transmission/infection is associated with head and neck cancers (HNCs) including recurrent respiratory papillomatosis. Read More

Otolaryngol Clin North Am 2019 Mar 26. Epub 2019 Mar 26.

Department of Otolaryngology-Head and Neck Surgery, University of Texas Voice Center, University of Texas Health Science Center-San Antonio, 8431 Fredricksburg Road, San Antonio, TX 78229, USA.

With fiber-based lasers that may be passed via the working channel of a flexible laryngoscope, in-office laser laryngeal surgery has become possible. The potassium-titanyl-phosphate laser has several features that make it ideal for laryngeal surgery, and it is now the laser of choice for in-office management of a variety of laryngeal lesions. Its applications have expanded significantly since its introduction, with reports of new indications continuing to appear in the literature. Read More

Infect Genet Evol 2019 Mar 21;71:140-150. Epub 2019 Mar 21.

Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Nagyerdei krt. 98, Hungary. Electronic address:

It is increasingly recognized that fundamental differences exist between high-risk and low-risk human papillomavirus (HPV) genotypes regarding interactions with the host. This study aims to join the recently emerging efforts to uncover these differences at the complete genome level and to study how they may influence the disease caused. Sixteen samples of thirteen patients with various HPV6-mediated benign mucosal disorders (nine recurrent respiratory papillomatoses with 2-8 recurrences, one condyloma acuminatum and three premalignant lesions of the genital mucosa) were sampled to determine the complete virus genomes. Read More

Eur J Health Econ 2019 Mar 21. Epub 2019 Mar 21.

Economic Evaluation and HTA (EEHTA)-CEIS, Faculty of Economics, University of Rome "Tor Vergata", Rome, Italy.

Introduction: The objectives of this study were to estimate the economic burden of HPV in Italy, accounting for total direct medical costs associated with nine major HPV-related diseases, and to provide a measure of the burden attributable to HPV 6, 11, 16, 18, 31, 33, 45, 52, 58 infections.

Methods: A cost-of-illness incidence-based model was developed to estimate the incidences and costs of invasive cervical cancer, cervical dysplasia, cancer of the vulva, vagina, anus, penis, oropharyngeal, anogenital warts, and recurrent respiratory papillomatosis (RRP) in the context of the Italian National Health System (NHS). We used data from hospital discharge records (HDRs) of an Italian region and conducted a systematic literature review to estimate the lifetime cost per case, the number of incident cases, the prevalence of HPV9 types. Read More

Ear Nose Throat J 2019 Mar 21:145561319837450. Epub 2019 Mar 21.

1 Department of Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine, Philadelphia, PA, USA.

Biomed Res Int 2019 10;2019:1463896. Epub 2019 Feb 10.

Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Ostrava, 17. Listopadu 1790, 70852 Ostrava, Czech Republic.

Introduction: Human papillomavirus (HPV) causes juvenile-onset recurrent respiratory papillomatosis (JORRP). Although HPV is common in children, the prevalence of JORRP is low. It is likely that other factors contribute to the pathogenesis of JORRP, during either activation or reactivation of a latent HPV infection. Read More

Cancer Epidemiol Biomarkers Prev 2019 Mar 13. Epub 2019 Mar 13.

Center for Translational Investigation in Oncology, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo.

Background: Human papillomavirus (HPV) types 6 and 11 are mainly associated with the development of genital warts and recurrent respiratory papillomatosis. We examined intra-typic genetic variability of both viral types with the development of cervical cytological abnormalities in Brazilian women.

Methods: We used PCR-sequencing to characterize variants of HPVs 6 and/or 11 in cervical swabs from women in the Ludwig-McGill Cohort Study. Read More

Ann Otol Rhinol Laryngol 2019 Mar;128(3_suppl):82S-93S

1 Department of Surgery, Harvard Medical School, Boston, MA, USA.

Background:: Anterior-commissure (AC) cicatrization and web formation is a difficult problem that can result from a variety of clinical scenarios. An advancement-rotation flap utilizing papillomatous epithelium and subepithelial fibrous tissue has been previously described. For patients in whom there was not excessive redundant papillomatosis covering the AC web, including other clinical scenarios, a microlaryngoscopic procedure was designed to lengthen the glottal/subglottal aperture using substantial local fibro-mucosal tissue. Read More

Ann Otol Rhinol Laryngol 2019 Mar;128(3_suppl):25S-32S

3 Department of Surgery, Harvard Medical School, Boston, MA, USA.

Introduction:: Recent reported evidence indicates that vocal cord carcinoma is evolving similarly to oropharyngeal cancer with an increasing number of patients without a smoking history having human papillomavirus (HPV) disease. Observations also suggest that an increasing number of patients who present with glottic carcinoma are younger than has been reported in the past. Therefore, an investigation was done to examine the incidence of glottic carcinoma in patients 30 years old (y/o) or younger. Read More

Oncologist 2019 Mar 6. Epub 2019 Mar 6.

Division of Hematology/Oncology, Georgetown Lombardi Comprehensive Cancer Center, MedStar Georgetown University Medical Center, Washington, D.C., USA.

Background: Juvenile-onset recurrent respiratory papillomatosis (JO-RRP) is a human papilloma virus-mediated progressive benign neoplasm that affects children and young adults. Primary management consists of regular surgical debulking to maintain airway patency and vocal function. Like condyloma acuminata, JO-RRP is associated with immune dysregulation, and T cells isolated from papillomas express an anergic phenotype. Read More

Ear Nose Throat J 2019 Jan 30;98(1):28-31. Epub 2019 Jan 30.

1 Department of Otorhinolaryngology and Head Neck Surgery, Institute of Post Graduate Medical Education and Research, SSKM Hospital, Kolkata, West Bengal, India.

A prospective observational study was conducted consisting of 21 patients of Juvenile-onset recurrent respiratory papillomatosis, attending the Department of Otorhinolaryngology and Head Neck Surgery at our institution, who underwent surgical excision of the papillomas followed by oral acyclovir postoperatively. The study was aimed to observe the effect of systemic acyclovir on postoperative outcomes in children having recurrent respiratory papillomatosis undergoing primary surgical excision. It was observed that the mean interval between surgeries as well as the number of surgical interventions required was significantly lesser when acyclovir was used as a postoperative adjuvant than when surgery was done alone. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;33(2):189-192

Recurrent respiratory papilloma (RRP) is closely related to human papillomavirus (HPV) infection and is the main pathogenic factor. At present, HPV vaccine injection is a new method to control RRP, and its efficacy has been confirmed by many clinical trials. The development and application of HPV vaccine is bound to bring new development to the treatment of RRP. Read More

Eur Arch Otorhinolaryngol 2019 Mar 26;276(3):801-803. Epub 2019 Feb 26.

Department of Otorhinolaryngology, Eye and ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.

Objective: To evaluate the efficacy of MMR vaccine in the treatment of juvenile-onset recurrent respiratory papillomatosis as adjuvant therapy by experimental research.

Methods: Thirty-one children with RRP were enrolled and assigned randomly to intervention group or control group. Fifteen subjects in intervention group were treated with local application MMR vaccine on the lesion after surgery; sixteen subjects in the control group were treated with surgical excision alone. Read More

Eur Arch Otorhinolaryngol 2019 Mar 23;276(3):793-800. Epub 2019 Feb 23.

Multidisciplinary Voice Service, Speech and Language Therapy Department, University Hospital Lewisham, Lewisham High Street, London, SE13 6LH, UK.

Purpose: Recurrent respiratory papillomatosis is a disease caused by the human papilloma virus (HPV). HPV is frequently localised in the larynx. The disease tends to recur and frequent intervention is usually required. Read More

J Voice 2019 Feb 19. Epub 2019 Feb 19.

Our Lady of the Lake Voice Center, Baton Rouge, Louisiana; Louisiana State University Health Sciences Center, School of Medicine, Department of Otolaryngology Head & Neck Surgery, New Orleans, Louisiana.

Objectives: Recurrent Respiratory Papillomatosis (RRP) is a rare disease caused by the human papilloma virus that presents as warty, exophytic growths in the upper airway. RRP in the larynx can lead to severe airway obstruction and voice changes. It is clinically known that patients with RRP frequently experience dysphonia. Read More

Euro Surveill 2019 Feb;24(7)

Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Facultad de Medicina, Universidad de Barcelona, Barcelona, España.

Introduction: Although human papillomavirus (HPV) routine vaccination programmes have been implemented around the world and recommendations have been expanded to include other high-risk individuals, current recommendations often differ between countries in Europe, as well as worldwide.

Aim: To find and summarise the best available evidence of HPV vaccination in high-risk patients aiding clinicians and public health workers in the day-to-day vaccine decisions relating to HPV in Spain.

Methods: We conducted a systematic review of the immunogenicity, safety and efficacy/effectiveness of HPV vaccination in high-risk populations between January 2006 and June 2016. Read More

Acta Otolaryngol 2018 Nov;138(11):1020-1027

a Department of Clinical Sciences, Division of Otorhinolaryngology , Umeå University , Umea , Sweden.

Background: Hyaluronan (HA) is a glycosaminoglycan with viscoelastic properties necessary for vocal fold (VF) vibration and voice production. Changes in HAs molecular mass, possibly related to human papilloma virus, could affect formation/persistence of recurrent respiratory papillomatosis (RRP). Aims/Objective: Describing mass and localization of HA and localization of HA receptor CD44 in VF and false vocal folds (FVF) in RRP. Read More

Lasers Med Sci 2019 Feb 14. Epub 2019 Feb 14.

Department of Otolaryngology, Head and Neck Surgery Poznań University of Medical Sciences, Przybyszewskiego 49, 60-355, Poznań, Poland.

Mechanical debulking of laryngeal papillomas is associated with voice disorders due to impairment of the vocal fold's mucosa. Intraepithelial injection of cidofovir reduces damage to the laryngeal structures and thus improves vocal parameters. The aim of our study was to compare vocal quality before and after cidofovir and CO laser treatment by means of objective phoniatric parameters and to obtain evidence concerning voice outcomes. Read More

Curr Opin Otolaryngol Head Neck Surg 2019 Apr;27(2):80-84

Department of Otolaryngology Head and Neck Surgery, First Faculty of Medicine, Charles University in Prague and University Hospital Motol Prague, Czech Republic.

Purpose Of Review: The role of HPV in oropharyngeal cancer is well recognized. HPV DNA is also found in a fraction of head and neck tumors outside of oropharynx but its clinical importance is unknown. The purpose of this review is to sum up the present knowledge about the prevalence and possible impact of HPV presence in head and neck tumors in nonoropharyngeal sites. Read More

Curr Opin Otolaryngol Head Neck Surg 2019 Apr;27(2):85-90

Department of Otorhinolaryngology, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, the Netherlands.

Purpose Of Review: To gain the evidence-based knowledge concerning the efficacy of HPV vaccination for oropharyngeal sites and to highlight the trials and strategies for vaccine administration in HPV-dependent head and neck diseases.

Recent Findings: Vaccination can be provided in two injections. There is increasing anecdotal evidence that therapeutic vaccination is effective in treatment of recurrent respiratory papillomatosis. Read More

Sex Transm Infect 2019 02 21;95(1):28-35. Epub 2018 Sep 21.

National Infection Service, Public Health England, London, UK

Background: Many economic evaluations of human papillomavirus vaccination should ideally consider multiple disease outcomes, including anogenital warts, respiratory papillomatosis and non-cervical cancers (eg, anal, oropharyngeal, penile, vulvar and vaginal cancers). However, published economic evaluations largely relied on estimates from single studies or informal rapid literature reviews.

Methods: We conducted a systematic review of articles up to June 2016 to identify costs and utility estimates admissible for an economic evaluation from a single-payer healthcare provider's perspective. Read More

Eur Arch Otorhinolaryngol 2019 Mar 17;276(3):897-899. Epub 2019 Jan 17.

Department of Otolaryngology and Laryngological Oncology, University of Medical Sciences, Poznan, Poland.

Introduction: Since 2015, the European Laryngological Society (ELS) has organized on a yearly basis the European Laryngological Live Surgery Broadcast. The goal of this paper is to demonstrate the increasing worldwide audience.

Material And Methods: The number of individual computers logged in, number of estimated audience, and number of countries with an active audience were calculated and compared to the numbers in 2015. Read More

Arch Argent Pediatr 2019 02;117(1):e72-e76

Servicio de Cirugía, Hospital General de Niños "Dr. Pedro de Etizalde", Ciudad de Buenos Aires, Argentina.

Recurrent respiratory papillomatosis is an infrequent benign neoplasm that commonly affects the upper airway with a predilection for the larynx. Isolated tracheobronchial involvement is very rare. Diagnosis and treatment of this disease is a challenge due to its non-specific clinical manifestation and its recurrent nature. Read More

Clin Otolaryngol 2019 Jan 7. Epub 2019 Jan 7.

ENT Department, BSUH NHS Trust, Brighton, UK.

Arch Bronconeumol 2019 Jan 2. Epub 2019 Jan 2.

Unidad de Fibrosis Quística, Hospital Universitario Virgen del Rocío, Sevilla, España; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, España.

Head Neck 2019 Mar 3;41(3):657-665. Epub 2019 Jan 3.

Virolab, S de RL de CV, Cuernavaca, Morelos, Mexico.

Background: Recurrent respiratory papillomatosis (RRP) or laryngeal papillomatosis is a disease caused by papillomavirus infection.

Methods: In this phase I/II clinical trial, we evaluated the efficacy of the modified vaccinia Ankara (MVA) E2 virus in the treatment of RRP. Twenty-nine patients (18 female and 11 male) underwent injection of MVA E2 directly into the borders of the vocal cords where lesions were seen and were monitored by direct laryngoscopy. Read More

Ann Otol Rhinol Laryngol 2019 Apr 29;128(4):309-315. Epub 2018 Dec 29.

1 Department of Otolaryngology - Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Objectives:: To investigate vaccine compliance and clinical outcomes after implementation of an initiative to provide the human papillomavirus (HPV) vaccine to all patients with recurrent respiratory papillomatosis (RRP).

Methods:: A retrospective review was performed of all adult patients treated for RRP from 2012 to 2017. Rates of HPV vaccination were evaluated before and after December 2015, when a program was established to increase compliance by educating patients and providing financial assistance toward vaccine administration. Read More

Laryngoscope 2019 Apr 26;129(4):1001-1004. Epub 2018 Dec 26.

Department of Otolaryngology-Head and Neck Surgery and Pediatric Department, Son Espases University Hospital, Palma de Mallorca, Spain.

Recurrent respiratory papillomatosis can be a devastating condition for a child, with severe consequences. Currently, there is no proven successful medical treatment. We describe the use of systemic bevacizumab to treat two children affected by aggressive recurrent respiratory papillomatosis. Read More

Auris Nasus Larynx 2018 Dec 20. Epub 2018 Dec 20.

Circulating Biomarkers Laboratory, Pathology Department, Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil.

Objective: The aim of this study was to investigate the presence of human papillomavirus (HPV) in biopsy specimens from juvenile and adult patients with histopathological diagnosis of recurrent respiratory papillomatosis (RRP) treated in two public hospitals in Rio de Janeiro, Brazil.

Methods: We performed the detection and genotyping of HPV by PCR technique for the types 6, 11, 16, and 18 in biopsy specimens from 41 RRP patients.

Results: The juvenile onset RRP (JoRRP) corresponded to 61% and the adult onset RRP (AoRRP) corresponded to 39% of the study group. Read More

Int J Pediatr Otorhinolaryngol 2019 Jan 26;116:147-152. Epub 2018 Oct 26.

Harare Eye, Ear, Nose and Throat Institute, Milton Park, Harare, Zimbabwe; Department of Surgery, Faculty of Medicine, University of Zimbabwe, Harare, Zimbabwe.

Objective: Recurrent respiratory papillomatosis (RRP) caused by human papillomavirus (HPV) is preventable through vaccination. This study was motivated by the recent thrust of the Zimbabwean government to reduce incidence of HPV related cervical cancer in Zimbabwe through vaccination against HPV. We therefore set out to type HPV genotypes causing RRP in Zimbabwe. Read More

Head Neck 2019 Feb 14;41(2):309-314. Epub 2018 Dec 14.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: Biomarkers that could predict malignant transformation of recurrent respiratory papillomatosis (RRP) would be useful in patient follow-up. We investigated whether serum matrix metalloproteinase 8 (MMP-8) and tissue inhibitor of metalloproteinase 1 (TIMP-1) could predict malignant transformation of RRP and whether they associate with survival in laryngeal squamous cell carcinoma (LSCC) without preexisting RRP.

Methods: We analyzed serum MMP-8 (S-MMP-8) and serum TIMP-1 (s-TIMP-1) in 114 patients: 55 were treated for RRP and 59 for LSCC without preexisting RRP. Read More

Ann Thorac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Cardiothoracic Surgery, Heart and Vascular Institute, Cleveland Clinic. Cleveland. Ohio. United States. Electronic address:

Recurrent Respiratory Papillomatosis (RRP) is a rare intractable benign disease with a bimodal age distribution. We present a rare case of malignant transformation of juvenile-onset RRP in a 19-year old pregnant female, who was found to have a right upper lobe mass and cavitary nodules bilaterally that were biopsy proven to be node negative, multifocal squamous cell carcinoma. In her second trimester, she underwent Video Assisted Thoracoscopic (VATS) right upper lobectomy and middle lobe lateral segmentectomy, followed by left lower lobe segmentectomy nine months later. Read More

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Feb 29;136(1):25-28. Epub 2018 Nov 29.

Department of Otolaryngology - Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Objective: The study objective was to determine risk factors for severity of juvenile-onset recurrent respiratory papillomatosis (RRP) at first endoscopic evaluation.

Methods: Based on a review of all cases undergoing surgery for juvenile-onset RRP in two pediatric otolaryngology departments in the USA and France, the following severity risk factors were analyzed: number of laryngeal levels involved, extension to the subglottis, and bilateral involvement.

Results: Thirty-two patients were included, with 571 endoscopic procedures. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Nov;53(11):825-829

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

To observe the clinical course of children with juvenile-onset recurrent respiratory papillomatosis (JORRP) until 14 years old. The clinical data of one hundred and twenty cases treated between Januray 1, 2002 and September 30, 2017 in Beijing Tongren Hospital were analyzed retrospectively. Excluding the deaths and the lost, patients who could be ≥ 5 years without recurrence, were defined as the cured group, and < 5 years with recurrence defined as the recurrent group. Read More

Radiographics 2018 Nov-Dec;38(7):2151-2172

From the Department of Radiology and Radiological Sciences (J.P.L., E.M.C.) and Department of Pathology (J.P.L., A.R.H., E.M.C.), Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814; Thoracic Radiology Section (J.P.L., D.M.B.) and Pediatric Radiology Section (D.M.B., E.M.C.), American Institute for Radiologic Pathology, Silver Spring, Md; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pa (D.M.B.); Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, Tex (B.W.C.); and Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (M.A.P.).

Primary lung tumors in children are rare, with a narrow range of diagnostic considerations. However, the overlapping imaging appearances of these tumors necessitate attention to key discriminating imaging and pathologic features. In the neonate and infant, the important considerations include pleuropulmonary blastoma (PPB), infantile fibrosarcoma, and fetal lung interstitial tumor. Read More

Radiographics 2018 Nov-Dec;38(7):2150

American Institute for Radiologic Pathology, Silver Spring, Maryland, and University of Maryland School of Medicine, Baltimore, Maryland ( ).

Respir Med Case Rep 2018 24;25:323-326. Epub 2018 Oct 24.

Pavlov First State Medical University, Saint-Petersburg, Saint-Petersburg, Russian Federation.

Recurrent respiratory papillomatosis (RRP) is a rare disease caused by human papillomavirus. Aggressive forms of RRP require repeated cytoreductive surgery to restore airway patency. Tracheal disease is even less common and lung parenchyma is involved in less than 1% of patients. Read More

Int J Pediatr Otorhinolaryngol 2018 Dec 28;115:120-124. Epub 2018 Sep 28.

Department of Respiratory Endoscopy, Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Argentina.

Objetives: To describe our experience in reconstructive laryngeal surgery in patients with recurrent respiratory papillomatosis (RRP).

Introduction: RRP is a rare laryngeal disease requiring multiple surgical endoscopic interventions during its course. These interventions may cause secondary lesions that may compromise airway patency. Read More

J Infect Dis 2019 Mar;219(7):1016-1025

Department of ORL-Head & Neck Surgery and Audiology, Odense University Hospital, Odense.

Background: Recurrent respiratory papillomatosis is a benign condition caused by human papillomavirus (HPV). Surgery is the mainstay of treatment, but numerous adjuvant therapies have been applied to improve surgical outcome. Recently, HPV vaccination has been introduced, but only smaller studies of its effect have been published. Read More

Clinics (Sao Paulo) 2018 10 11;73(suppl 1):e486s. Epub 2018 Oct 11.

Centro de Pesquisa Translacional em Oncologia, Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Human papillomavirus infection is associated with the development of malignant and benign neoplasms. Approximately 40 viral types can infect the anogenital mucosa and are categorized into high- and low-risk oncogenic human papillomavirus, depending on their association with the development of cervical carcinoma. High-risk human papillomavirus 16 and 18 are detected in 55% and 15% of all invasive cervical squamous cell carcinomas worldwide, respectively. Read More

Respirol Case Rep 2018 Nov 2;6(8):e00371. Epub 2018 Oct 2.

Thoracic Medicine Department The Royal Brisbane and Woman's Hospital Brisbane Australia.

Recurrent respiratory papillomatosis (RRP) is a rare condition that affects the respiratory system. It is caused by human papilloma virus (HPV) infection. Usually infection and papilloma growth is limited to 6-12 months duration; however, some patients have persistent disease, resulting in long-term symptoms and the need for recurrent intervention. Read More

PLoS One 2018 9;13(10):e0205554. Epub 2018 Oct 9.

Department of Otolaryngology, Head and Neck Surgery, Poznań University of Medical Sciences, Poznań, Poland.

Objectives/hypothesis: Recurrent respiratory papillomatosis (RRP) is a benign disease caused by human papillomavirus 6 and 11. The characteristic feature of this disease are wart-like lesions covering the respiratory epithelium with a predilection for the larynx. There is no curative treatment for the disease. Read More

Curr Opin Otolaryngol Head Neck Surg 2018 Dec;26(6):421-425

Department of Otolaryngology - Head and Neck Surgery.

Purpose Of Review: Recurrent respiratory papillomatosis (RRP) is the most common as well as the costliest benign airway neoplasm in the United States [Ivancic et al. (2018). Laryngoscope Investig Otolaryngol 3:22; Derkay (1995). Read More

Hum Vaccin Immunother 2019 27;15(1):141-145. Epub 2018 Sep 27.

g Merck & Co., Inc ., Kenilworth , NJ , USA.

Background: This exploratory analysis was conducted to characterize the level of HPV types 6/11 antibodies in peripartum maternal blood and in cord blood of infants born to women who received 9-valent HPV (9vHPV) vaccine or quadrivalent HPV (qHPV) vaccine in a pivotal efficacy study (V503-001, NCT 00543543).

Methods: A total of 21 mother-infant pairs had evaluable HPV 6/11 results available for analysis. HPV6/11 antibodies were assessed using competitive Luminex immunoassay. Read More

J Voice 2018 Sep 14. Epub 2018 Sep 14.

The 2nd Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China. Electronic address:

Objectives: To assess the safety and immunogenicity of a nonadjuvant human papillomavirus (HPV) type 6 L1 virus-like particle (VLP) vaccine in recurrent respiratory papillomatosis (RRP) in local Chinese patients.

Methods: Patients with RRP who had undergone surgical treatment before intramuscular administration of an escalating dose of HPV type 6 L1 VLPs (1, 5, and 25 µg at 4 weekly intervals) as part of their treatment were followed up for more than 10 years. Efficacy was assessed by detecting the vaccine-induced type-specific antibody titer, calculating the intersurgical interval, and observing recurrence or remission of papillomas after receiving the vaccine. Read More

Otolaryngol Pol 2018 Jun;72(4):1-8

Poznan University of Medical Sciences Department of Otolaryngology and Laryngological Oncology.

Objective: Recurrent respiratory papillomatosis (RRP) is caused by human papilloma virus types 6 and 11 and occurs in both children and adults. It is characterized by the proliferation of benign squamous papillomas within the aerodigestive tract. The problem with recurrent respiratory papillomatosis treatment is the high recurrence of papilloma growth after surgical removal. Read More

Autops Case Rep 2018 Jul-Sep;8(3):e2018035. Epub 2018 Jul 30.

Santa Casa de São Paulo School of Medical Sciences, School of Medicine. São Paulo, SP, Brazil.

Papilloma associated with recurrent respiratory papillomatosis (RRP), caused by human papilloma virus (HPV) infection types 6 and 11, is the most common benign neoplasm of the larynx. The clinical features of RRP vary widely from mild to aggressive forms. RRP in children is known as juvenile-onset recurrent respiratory papillomatosis (JORRP). Read More

JAMA Otolaryngol Head Neck Surg 2018 Sep;144(9):831-837

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston.

Importance: Recurrent respiratory papillomatosis (RRP) is a viral-induced disease caused by human papillomavirus and the second leading cause of dysphonia in children; however, neither a cure nor a definitive surgical treatment is currently available for RRP. Although laser therapy is often used in the treatment of RRP, the lack of real-time laser-tissue interaction feedback undermines the ability of physicians to provide treatments with low morbidity. Therefore, an intraoperative tool to monitor and control laser treatment depth is needed. Read More