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Otolaryngol Head Neck Surg 2020 Jun 23:194599820931817. Epub 2020 Jun 23.

Bastian Voice Institute, Downers Grove, Illinois, USA.

Objective: To define the human papillomavirus (HPV) subtypes seen in a large adult population with traditionally defined recurrent respiratory papillomatosis.

Study Design: Retrospective review.

Setting: Tertiary care laryngology practice. Read More

Acta Otolaryngol 2020 Jun 3:1-6. Epub 2020 Jun 3.

Key Laboratory of Major Disease in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Aggressive juvenile-onset recurrent respiratory papillomatosis (JORRP) threatens patient lives if not receives immediate surgical intervene. Even with surgical intervene, complete remission of this disease is not approachable. Therefore, understanding the factors relevant to disease severity and prognosis will do help to the treatment strategy and health management of this disease. Read More

Int J STD AIDS 2020 Jun 21;31(7):606-612. Epub 2020 May 21.

Department of Dermatology and Venereology, Hospital de Baza, Granada, Spain.

Human papillomavirus (HPV) is the most prevalent sexually transmitted infection worldwide and ano-genital warts (AGWs) are highly infectious. This virus is transmitted through sexual, anal, or oral contact as well as skin-to-skin contacts. Treatment for this condition has significant morbidity and it can be frustrating in certain cases. Read More

Hum Genet 2020 Jun 20;139(6-7):919-939. Epub 2020 May 20.

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-1163, Necker Hospital for Sick Children, Paris, EU, France.

Human papillomaviruses (HPVs) infect mucosal or cutaneous stratified epithelia. There are 5 genera and more than 200 types of HPV, each with a specific tropism and virulence. HPV infections are typically asymptomatic or result in benign tumors, which may be disseminated or persistent in rare cases, but a few oncogenic HPVs can cause cancers. Read More

Biosci Rep 2020 May;40(5)

Department of Otolaryngology, The Second Affiliated Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China.

Laryngeal papillomatosis is a benign disease in the larynx but with the potential to develop into significant complications as a result of its high recurrence rate. CO2 laser and radiofrequency controlled ablation (coblation) have been used to treat recurrent respiratory papillomatosis, but detailed comparisons of their respective treatment outcomes are not fully investigated. This retrospective study examines the procedure time, time interval between interventions, blood loss during operation, post-operative complications and pain scores among patients who received either CO2 laser or radiofrequency coblation interventions for laryngotracheal recurrent respiratory papillomatosis. Read More

J Voice 2020 Apr 30. Epub 2020 Apr 30.

Rey Caro Voice Center, Rey Caro Ear, Nose and Throat Service, Cordoba, Argentina. Electronic address:

Recurrent Respiratory Papillomatosis is a highly recurrent and residual disease. The use of indigo-carmine chromoendoscopy increases the early detection of nonvisible disease and reduces the possibility of leaving residual lesions. The best chances of papillomatosis being eradicated depend upon a surgical shallow epitheliolysis approach applied to patients who have never been surgically damaged before. Read More

Acta Otorrinolaringol Esp 2020 Apr 17. Epub 2020 Apr 17.

Departamento de Otorrinolaringología y Cirugía de Cabeza y Cuello, Emory University School of Medicine, Atlanta, Estados Unidos. Electronic address:

Recurrent respiratory papillomatosis (RRP) consist of benign tumours along the airway caused by human papillomavirus infection. Papillomas may cause changes in phonation and obstruct the airway. The purpose of this study was to evaluate the different surgical and adjuvant therapies available for the treatment of this condition reported between 2014-2018. Read More

Eur Clin Respir J 2020 12;7(1):1740567. Epub 2020 Mar 12.

Department of Respiratory Medicine, Odense University Hospital, Denmark.

Radiological presentation of bronchiectasis should prompt the respiratory physician to investigate various differential diagnosis leading to this condition. This case report describes a young non-smoking woman with HPV11 induced laryngeal Recurrent Respiratory Papillomatosis (RRP) since early childhood, who developed progressive exertional dyspnea. A thorough diagnostic process revealed HPV11 infection in the lung parenchyma consistent with RRP in the lower airways, an HPV infection that was most likely obtained from the patient´s mother during vaginal birth. Read More

Front Immunol 2020 10;11:336. Epub 2020 Mar 10.

Barbara and Donald Zucker School of Medicine at Hofstra/Northwell, Feinstein Institutes for Medical Research, Manhasset, NY, United States.

The micromilieu within respiratory papillomas supports persistent human papillomavirus (HPV) infection and disease recurrence in patients with recurrent respiratory papillomatosis (RRP). These patients show polarized (T2-/Treg) adaptive immunity in papillomas and blood, enriched immature Langerhans cell (iLC) numbers, and overexpression of cyclooxygenase-2/prostaglandin E (PGE) in the upper airway. Blood monocyte-derived, and tissue-derived iLCs from RRP patients and controls were now studied to more fully understand innate immune dysregulation in RRP. Read More

PLoS One 2020 11;15(3):e0230106. Epub 2020 Mar 11.

Merck & Co., Inc., (MSD), North Wales, Pennsylvania, United States of America.

Background: Recurrent respiratory papillomatosis (RRP) is characterized by repeated formation of papillomas in the respiratory tract and is caused by human papillomavirus (HPV) types 6 and 11. Women with genital HPV infection are slow to develop weak humoral immunity, but respond robustly to the HPV vaccine. We wondered if people with RRP had a similar immune response. Read More

Photodiagnosis Photodyn Ther 2020 Jun 4;30:101711. Epub 2020 Mar 4.

University of California San Diego, Division of Pulmonary, Critical Care, & Sleep Medicine, La Jolla, CA, United States.

Objective: Recurrent respiratory papillomatosis (RRP) causes mucosal wart-like growths of the upper aerodigestive tract, which can undergo malignant transformation. These tumors are difficult to treat, often requiring repeated debridement, which can be associated with high morbidity. Photodynamic therapy (PDT) uses a photosensitizing medication and a topically applied light source to treat early stage endobronchial lung cancer. Read More

Acta Med Port 2020 Mar 2;33(3):198-201. Epub 2020 Mar 2.

Department of Gynaecology. Hospital and University Centre of Coimbra. Coimbra. Department of Gynaecology. Faculty of Medicine. University of Coimbra. Coimbra. Portugal.

Introduction: Human papillomavirus is responsible for almost all cases of cervical cancer, an important portion of anogenital and oropharyngeal invasive and preinvasive lesions, as well as genital warts (condyloma acuminatum) and recurrent respiratory papillomatosis. Currently, three prophylactic vaccines against high-risk Human papillomavirus are commercialized in many countries worldwide.

Methods: To this non-systematic review the authors searched in MEDLINE/PubMed for systematic reviews, meta-analysis and randomized controlled trials, published in the last six years, using the terms "HPV", "non-cervical cancer" and "vaccine". Read More

Pediatric Health Med Ther 2020 4;11:39-46. Epub 2020 Feb 4.

Department of Otorhinolaryngology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.

Recurrent respiratory papillomatosis (RRP) is a condition caused by human papillomavirus (HPV), usually HPV types 6 and 11, which is characterized by recurrent papillomas of the respiratory tract, mainly the larynx. Patients usually present between the ages of 2 and 6 years. The initial presenting symptom is progressive dysphonia, followed by stridor and respiratory distress. Read More

Laryngoscope Investig Otolaryngol 2019 Jun 14;4(3):323-327. Epub 2019 Feb 14.

Department of Otolaryngology-Head and Neck Surgery University of Iowa Hospitals and Clinics Iowa City Iowa U.S.A.

Objectives: Tissue effects occurring with potassium-titanyl phosphorous (KTP) laser treatment are difficult to quantify due to the multiple variables that affect not only the fluence (energy delivered) but also the laser-tissue interaction. This histopathologic analysis of recurrent respiratory papilloma (RRP) removed after treatment with KTP laser therapy permits correlation of histologic effect with method of laser treatment.

Methods: The histopathology of RRP resected specimens in a single patient was compared following treatment with KTP laser in contact and non-contact modes as documented with intraoperative photography and video imaging. Read More

Eur Rev Med Pharmacol Sci 2020 Jan;24(2):956-962

Department of Adult and Development Age Human Pathology "Gaetano Barresi", Unit of Otorhinolaryngology, University of Messina, Messina, Italy.

Objective: Recurrent respiratory papillomatosis (RRP) is characterized by exophytic, benign, and papillary lesions infected by the virus in the epithelium of the upper aerodigestive tract. RRP is caused by persistent infection of the respiratory epithelium by human papillomavirus (HPV) HPV6 and-11. The clinical course of RRP is unpredictable, frequently relapsing, and may be lifelong. Read More

Vaccines (Basel) 2020 Jan 29;8(1). Epub 2020 Jan 29.

Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA 19462, USA.

Background: Recurrent respiratory papillomatosis (RRP) is a rare disorder characterized by the generation of papillomas of the aerodigestive tract, usually associated with human papilloma virus (HPV) subtypes 6, 11. INO-3106 is a DNA plasmid-based immunotherapy targeting E6 and E7 proteins of HPV6, in order to create a robust immune T cell response.

Methods: Testing of INO-3016 in animal models confirmed immunogenicity of the DNA-based therapy. Read More

JAMA Otolaryngol Head Neck Surg 2020 Jan 2. Epub 2020 Jan 2.

Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor.

Importance: The use of intralesional cidofovir injections for recurrent respiratory papillomatosis (RRP) remains controversial owing to concern regarding the risks of its use, including increased risk of dysplasia or carcinogenesis.

Objective: To describe the rates of dysplasia, development of malignant lesions, and adverse events associated with use of intralesional cidofovir injections as adjuvant treatment for RRP compared with patients treated without adjuvant cidofovir.

Design, Setting, And Participants: In this case series performed at a tertiary care referral center, review of electronic medical records on all adult and pediatric patients (N = 154) treated for RRP with adequate follow-up from January 1, 2000, to December 31, 2016, was performed. Read More

Actas Urol Esp 2020 03 23;44(2):86-93. Epub 2019 Dec 23.

Departamento de Urología, Fundació Puigvert, Universitat Autònoma de Barcelona, Barcelona, España.

Human papilloma virus (HPV) infection is the most common sexually transmitted infection worldwide. There is a high detection rate in sexually active young people but the risk, in males, persists over years. Currently, the American Center for Disease Control and Prevention does not recommend the evaluation of men for HPV and, the extant bibliography, backs up this stance for several reasons. Read More

Laryngoscope 2019 Dec 20. Epub 2019 Dec 20.

Center for Translational Investigation in Oncology, Instituto do Cancer do Estado de Sao Paulo, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Objective: The objective was to investigate the prevalence of the Epstein-Barr virus (EBV) and its association with human papilloma virus (HPV) detection, clinicopathological features, and the severity of recurrent respiratory papillomatosis (RRP).

Methods: Cases of juvenile recurrent respiratory papillomatosis (JRRP) (n = 36) and adult recurrent respiratory papillomatosis (ARRP) (n = 44) were collected retrospectively and subdivided into low- and high-risk severity groups based on the Derkay score. We performed HPV detection and genotyping using a reverse hybridization protocol and investigated the presence of EBV by polymerase chain reaction (PCR) and in situ hybridization. Read More

Int J Pediatr Otorhinolaryngol 2020 Mar 14;130:109815. Epub 2019 Dec 14.

Department of Respiratory Endoscopy, Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Argentina.

Objective: to describe the frequency and predictive factors associated with laryngeal scarring caused by surgical treatment of recurrent respiratory papillomatosis (RRP) in children.

Introduction: RRP is an important cause of hoarseness and respiratory obstruction in children. The current standard of care for RRP is the systematic and repetitive surgical interventions. Read More

Otolaryngol Head Neck Surg 2020 Feb 17;162(2):234-240. Epub 2019 Dec 17.

Department of Otolaryngology, Children's National Medical Center, Washington, DC, USA.

Objective: To discuss the presentation, evaluation, and management of pediatric laryngeal web.

Study Design: Retrospective case series.

Setting: Single tertiary care center. Read More

Am J Otolaryngol 2020 Mar - Apr;41(2):102321. Epub 2019 Nov 18.

Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, São Paulo State University - UNESP, São José dos Campos, Brazil. Electronic address:

Objective: To characterize inflammatory cells in Recurrent Respiratory Papillomatosis (RRP) and to correlate it with severity using the Derkay laryngoscopic scale.

Materials And Methods: The data and biopsies from 36 patients with Juvenile (JRRP) and 56 patients with Adult (ARRP) were collected and analyzed under light microscopy. The patients were separated into groups according to the Derkay index: ≥20 for the most severe and < 20 for the less severe cases. Read More

Emerg Microbes Infect 2019 ;8(1):1721-1733

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen, People's Republic of China.

Human papillomavirus type 6 (HPV6) is the major etiologic agent of genital warts and recurrent respiratory papillomatosis. Although the commercial HPV vaccines cover HPV6, the neutralization sites and mode for HPV6 are poorly understood. Here, we identify the HPV6 neutralization sites and discriminate the inhibition of virus attachment and entry by three potent neutralizing antibodies (nAbs), 5D3, 17D5, and 15F7. Read More

Vaccine 2020 01 22;38(5):1186-1193. Epub 2019 Nov 22.

Centre for Women's Infectious Diseases, The Royal Women's Hospital, Melbourne, Victoria, Australia; Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia. Electronic address:

Introduction: Australia has recently implemented major changes in cervical cancer prevention policies including introduction of primary human papillomavirus (HPV) screening starting at age 25, and replacement of the quadrivalent HPV vaccine with the nonavalent vaccine in the national school-based program. We assessed the feasibility and utility of conducting HPV testing in residual clinical specimens submitted for routine Chlamydia trachomatis screening, as a means of tracking HPV vaccine program impact among young sexually active women.

Methods: De-identified residual specimens from women aged 16-24 years submitted for chlamydia testing were collected from three pathology laboratories in Victoria and New South Wales. Read More

Case Rep Otolaryngol 2019 16;2019:7394879. Epub 2019 Oct 16.

Department of Sexually Transmitted Disease, Tongji University Affiliated Shanghai Skin Disease Hospital, Shanghai 200443, China.

Recurrent respiratory papillomatosis is a noninvasive benign epithelial tumor caused by human papillomavirus. Clinically, it featured rapid growth, multifocus, and frequent recurrence. Though a number of therapies have been investigated, the recurrence after treatment is always a challenge. Read More

BMJ Case Rep 2019 Nov 14;12(11). Epub 2019 Nov 14.

UOC Otorinolaringoiatria - Polo Pontino, Università degli Studi di Roma La Sapienza Facoltà di Medicina e Odontoiatria, Roma, Italy.

Recurrent respiratory papillomatosis (RRP) is caused by persistent infection of the respiratory epithelium by human papillomavirus (HPV), especially HPV 6 and 11. We present a case of surgically treated RRP. The main purpose of our protocol is to remove the lesions with a non-aggressive surgical technique and prevent recurrences with the use of cidofovir for local infiltrations in multiple sessions. Read More

Immunol Lett 2020 01 11;217:49-55. Epub 2019 Nov 11.

Key Laboratory of Otolaryngology Head and Neck Surgery (Ministry of Education of China), Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, PR China. Electronic address:

Background: Representing the first line of host defense against virus infections and an essential link between innate and adaptive immune response, the role of dendritic cells (DCs) in peripheral blood of juvenile-onset recurrent respiratory papillomatosis (JORRP) patients and association with disease activity were still not established.

Materials And Methods: In our present study, 28 JORRP patients and 28 age and sex matched healthy controls were enrolled. The percentage, phenotype and cytokine secretion of DC and was measured by flow cytometry. Read More

Sci Rep 2019 11 12;9(1):16625. Epub 2019 Nov 12.

Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, NY, USA.

Recurrent Respiratory Papillomatosis (RRP) is a rare disease of the aerodigestive tract caused by the Human Papilloma Virus (HPV) that manifests as profoundly altered phonatory and upper respiratory anatomy. Current therapies are primarily symptomatic; enhanced insight regarding disease-specific biology of RRP is critical to improved therapeutics for this challenging population. Multiplex PCR was performed on oral rinses collected from twenty-three patients with adult-onset RRP every three months for one year. Read More

Int J Pediatr Otorhinolaryngol 2020 Feb 31;129:109762. Epub 2019 Oct 31.

Department of Otolaryngology-Head and Neck Surgery, West Virginia University, Morgantown, WV, USA. Electronic address:

Recurrent Respiratory Papillomatosis (RRP) is a benign disease of the airway that can result in symptoms ranging from mild dysphonia to respiratory distress to respiratory failure related to colonization of the lung parenchyma. It is a disease that typically begins in childhood and can require treatment indefinitely, though may remit in adolescence. Although treatment includes surgical management, certain cases require adjuvant therapy. Read More

Int J Pediatr Otorhinolaryngol 2020 Jan 28;128:109697. Epub 2019 Sep 28.

Department of Otolaryngology & Communication Enhancement, Boston Children's Hospital, Boston, MA, United States.

Objectives: To develop consensus recommendations for the evaluation and management of juvenile-onset recurrent respiratory papillomatosis (JORRP) in pediatric patients.

Methods: Expert opinion by the members of the International Pediatric Otolaryngology Group (IPOG). The mission of the IPOG is to develop expertise-based consensus recommendations for the management of pediatric otolaryngologic disorders with the goal of improving patient care. Read More

Clin Exp Immunol 2020 Feb 31;199(2):131-142. Epub 2019 Oct 31.

Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.

Recurrent respiratory papillomatosis (RRP) is characterized by benign exophytic lesions of the respiratory tract caused by the human papillomavirus (HPV), in particular low-risk HPV6 and HPV11. Aggressiveness varies greatly among patients. Surgical excision is the current standard of care for RRP, with adjuvant therapy used when surgery cannot control disease recurrence. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Oct;33(10):945-950

Department of Head and Neck Surgery，Renji Hospital，Shanghai Jiao Tong University School of Medicine，Shanghai，200001，China.

To explore the signal pathway that mediates the effect of 2-methoxyestradiol（2ME2） on human laryngeal papilloma cell line, in terms of cell proliferation and neovascularization. HIF-1α expression of human laryngeal papilloma cell line（Hs840. T） was interfered using siRNA, and the cells were then processed by 2ME2 in two concentrations. Read More

Front Pediatr 2019 18;7:383. Epub 2019 Sep 18.

Sheikh Zayed Center for Pediatric Surgical Innovation, Children's National Health System, Washington, DC, United States.

Recurrent respiratory papillomatosis (RRP) is the recurrent growth of small, benign tumors, or papillomas, in the respiratory tract, caused by human papillomavirus (HPV). Currently, there is no cure. Palliative treatments seek to prevent airway obstruction, keep underlying tissues healthy, and maintain voice quality. Read More

Ugeskr Laeger 2019 Oct;181(41)

Recurrent respiratory papillomatosis (RRP) is a condition with benign tumours in the respiratory tract. RRP ensues in both children and adults. The disease is induced by low-risk human papillomavirus (HPV) types HPV-6 and HPV-11. Read More

Int J Pediatr Otorhinolaryngol 2020 Jan 8;128:109706. Epub 2019 Oct 8.

Division of Pediatric Otolaryngology, Children's National Health System, Washington, DC, USA. Electronic address:

We report on two cases of severe recurrent respiratory papillomatosis (RRP) involvement where the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab IV has been administered for treatment. Notably, there have not been any episodes of urgent transfer to the hospital for obstructive events since the bevacizumab was started. It is important to note however, that the disease has not been eliminated. Read More

Acta Otolaryngol 2019 Dec 26;139(12):1133-1139. Epub 2019 Sep 26.

Department of Otolaryngology, The 4th Medical Center of the PLA General Hospital, Beijing, China.

Recurrent respiratory papillomatosis (RRP) remains a challenging and frustrating disease to treat. To explore the efficacy of microsurgery in combined with Topical-PDT in treating recurrent respiratory papillomatosis. Fifty patients with RRP were treated with microsurgery in combined with Topical-PDT. Read More

Proc Natl Acad Sci U S A 2019 09 4;116(38):19055-19063. Epub 2019 Sep 4.

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, 10065;

Juvenile-onset recurrent respiratory papillomatosis (JRRP) is a rare and debilitating childhood disease that presents with recurrent growth of papillomas in the upper airway. Two common human papillomaviruses (HPVs), HPV-6 and -11, are implicated in most cases, but it is still not understood why only a small proportion of children develop JRRP following exposure to these common viruses. We report 2 siblings with a syndromic form of JRRP associated with mild dermatologic abnormalities. Read More

Papillomavirus Res 2019 12 22;8:100181. Epub 2019 Aug 22.

Department of Pathology, Georgetown University, Medical School, Washington DC, 20057, USA. Electronic address:

Recurrent respiratory papillomatosis (RRP) is a benign neoplasm of the larynx caused mainly by human papillomavirus type 6 or 11 and its standard treatment involves repeated surgical debulking of the laryngeal tumors. However, significant morbidity and occasional mortality due to multiple recurrences occur. Conditional reprogramming (CR) was used to establish a HPV-6 positive culture from an RRP patient, named GUMC-403. Read More

Laryngorhinootologie 2019 Aug 6;98(8):577-587. Epub 2019 Aug 6.

Recurrent Respiratory Papillomatosis (RRP) is a rare infectious disease of the upper aerodigestive tract caused by human papillomavirus (HPV). Virus subtypes 6 and 11 are found in most of the papillomas, type 11 is associated with a severe course. There are a juvenile and an adult form defined by age of initial manifestation. Read More

Head Neck Pathol 2020 Jun 27;14(2):428-434. Epub 2019 Jul 27.

Department of Pathology, The Icahn School of Medicine at Mount Sinai Hospital, Annenberg Bldg. 15-54, 1468 Madison Ave, New York, NY, 10029, USA.

Squamous papillomas (SPs) of the head and neck are generally regarded as a human papillomavirus (HPV)-driven process, but reported rates of HPV detection vary dramatically. Moreover, they are generally considered a benign condition, but the detection of high risk HPV types is commonly reported. This latter finding is particularly disturbing to clinicians and their patients given the alarming rise of HPV-associated head and neck cancer. Read More

N Engl J Med 2019 Jul;381(4):358

Policlinico S. Orsola, Bologna, Italy

J Med Case Rep 2019 Jul 15;13(1):215. Epub 2019 Jul 15.

Department of Otorhinolaryngology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.

Background: Recurrent respiratory papillomatosis is a chronic disease of viral origin affecting the larynx, trachea, and lower airways. Inverted papilloma, most commonly originating from the lateral nasal wall, is typically a single, expansile, locally aggressive tumor that remodels bone around the site of origin.

Case Presentation: We report a case of histopathologically proven inverted papilloma occurring in a 50-year-old Caucasian man with recurrent respiratory papillomatosis affecting his nasal cavity, larynx, and trachea. Read More

Laryngoscope Investig Otolaryngol 2019 Jun 25;4(3):328-334. Epub 2019 Mar 25.

Vanderbilt Bill Wilkerson Center for Otolaryngology Vanderbilt University Medical Center Nashville Tennessee U.S.A.

Objective: Acoustic analysis of voice has the potential to expedite detection and diagnosis of voice disorders. Applying an image-based, neural-network approach to analyzing the acoustic signal may be an effective means for detecting and differentially diagnosing voice disorders. The purpose of this study is to provide a proof-of-concept that embedded data within human phonation can be accurately and efficiently decoded with deep learning neural network analysis to differentiate between normal and disordered voices. Read More

PLoS One 2019 13;14(6):e0216697. Epub 2019 Jun 13.

Departments of Microbiology and Immunology, and Otolaryngology-Head and Neck Surgery and Center for Genomic Sciences, Institute of Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America.

Background: Recurrent Respiratory Papillomatosis (RRP) is a rare disease characterized by the growth of papillomas in the airway and especially the larynx. The clinical course is highly variable among individuals and there is poor understanding of the factors that drive an aggressive vs an indolent course.

Methods: A convenience cohort of 339 affected subjects with papillomas positive for only HPV6 or HPV11 and clinical course data available for 1 year or more, from a large multicenter international study were included. Read More

Laryngoscope 2020 May 13;130(5):1186-1194. Epub 2019 Jun 13.

Department of Management, Policy, and Community Health the University of Texas Health Science Center, Houston, TX.

Objectives: The study objective was to estimate the first 2 years' direct costs of treating new cases of juvenile-onset and adult-onset recurrent respiratory papillomatosis (RRP) and determine the predictors of treatment costs.

Methods: Cases were patients diagnosed with RRP in commercial insurance claims in 2011-2014 and Texas Medicaid in 2008-2012 for treatment of RRP. Controls were patients without a diagnosis of HPV-related cancer or RRP, matched with cases by age, sex, geographic area, date of diagnosis of RRP, and propensity score. Read More

Exp Ther Med 2019 Jun 22;17(6):4337-4343. Epub 2019 Apr 22.

Department of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece.

Almost 10 years ago, in October, 2008, the scientist who reported for the first time the association between human papillomaviruses (HPV) and cervical cancer, was awarded with the Nobel prize. In the years that followed, Professor Harald zur Hausen actively supported the value of the HPV vaccination in the prevention of different types of cancer and highlighted the necessity of its introduction in both girls and boys. However, to date, in the majority of countries, HPV vaccination among male adolescents has not been implemented into the national vaccination schemes, while in several countries, including Greece, the participation rate to HPV vaccination among female adolescents still remains low. Read More

J Am Acad Dermatol 2020 Jan 11;82(1):202-212. Epub 2019 May 11.

Department of Dermatology, University of California, Irvine, California.

Background: Human papillomavirus (HPV) infections are associated with common dermatologic and nondermatologic diseases. Although HPV vaccines are well established as preventive measures for genital warts and cervical neoplasia, their use as therapeutic agents deserves greater attention.

Objective: To evaluate the use of HPV vaccine(s) as a treatment modality for cutaneous and/or mucosal disease. Read More

Otolaryngol Clin North Am 2019 Aug 8;52(4):669-679. Epub 2019 May 8.

Department of Otolaryngology-Head and Neck Surgery, Eastern Virginia Medical School, Sentara Norfolk General Hospital, 600 Gresham Drive, Suite 1100, Norfolk, VA 23507, USA.

Recurrent respiratory papillomatosis (RRP) remains a challenging disease afflicting children and adults, resulting in an estimated $120 million per year in United States healthcare-related costs, with annual costs per patient approaching $60,000. Although the prevalence of RRP has declined, RRP remains the most common benign laryngeal neoplasm in children. RRP is unique in its high rate of multisite recurrence, its high burden on patient quality of life, and its high associated healthcare costs. Read More

Laryngoscope 2019 09 6;129(9):1993-1997. Epub 2019 May 6.

New York University Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York, New York, U.S.A.

Objectives/hypothesis: To describe recurrence patterns in patients with recurrent respiratory papillomatosis (RRP) following surgical intervention.

Study Design: Single-center, retrospective, longitudinal case series.

Methods: Initial and follow-up laryngoscopic examinations of seven previously untreated adult-onset RRP patients were reviewed. Read More

J Immunother Cancer 2019 05 3;7(1):119. Epub 2019 May 3.

Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA.

Background: Recurrent respiratory papillomatosis (RRP) is a human papillomavirus (HPV)-driven disorder that causes substantial morbidity and can lead to fatal distal airway obstruction and post-obstructive pneumonias. Patients require frequent surgical debridement of disease, and no approved systemic adjuvant therapies exist.

Methods: A phase II study was conducted to investigate the clinical activity and safety of programmed death-ligand 1 (PD-L1) blockade with avelumab in patients with RRP. Read More