588,619 results match your criteria Respiratory Medicine: COPD Update [Journal]


Letter from Greece.

Respirology 2019 Apr 22. Epub 2019 Apr 22.

Associate Professor of Respiratory Medicine, University of Ioannina, Ioannina, Greece.

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http://dx.doi.org/10.1111/resp.13568DOI Listing

Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar Dynein function in primary cilia.

Hum Mol Genet 2019 Apr 22. Epub 2019 Apr 22.

St. Vincent's Institute of Medical Research.

Mutations in subunits of the cilia-specific cytoplasmic Dynein-2 (CD2) complex cause short-rib thoracic dystrophy syndromes (SRTDs), characterized by impaired bone growth and life-threatening perinatal respiratory complications. Different SRTD mutations result in varying disease severities. It remains unresolved whether this reflects the extent of retained hypomorphic protein functions or relative importance of the affected subunits for the activity of the CD2 holoenzyme. Read More

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http://dx.doi.org/10.1093/hmg/ddz083DOI Listing

Maternal Glycemic Control in Type 1 Diabetes and the Risk for Preterm Birth: A Population-Based Cohort Study.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

Karolinska Institutet, Stockholm, Sweden, and Statens Serum Institut, Copenhagen, Denmark (B.P.).

Background: Maternal type 1 diabetes (T1D) has been linked to preterm birth and other adverse pregnancy outcomes. How these risks vary with glycated hemoglobin (or hemoglobin A1c [HbA1c]) levels is unclear.

Objective: To examine preterm birth risk according to periconceptional HbA1c levels in women with T1D. Read More

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http://dx.doi.org/10.7326/M18-1974DOI Listing

Life-time exposure to waterborne copper III: Effects on the energy metabolism of the killifish Poecilia vivipara.

Chemosphere 2019 Apr 12;227:580-588. Epub 2019 Apr 12.

Programa de Pós-graduação Em Ciências Fisiológicas, Universidade Federal Do Rio Grande, Avenida Itália Km 8, Campus Carreiros, 96203-900, Rio Grande, RS, Brazil; Instituto de Ciências Biológicas, Universidade Federal Do Rio Grande, Avenida Itália Km 8, Campus Carreiros, 96203-900, Rio Grande, RS, Brazil. Electronic address:

Copper ions (Cu) are essential to life maintenance, nonetheless, elevated concentrations can be hazardous. Acute and sub-chronic toxic effects of this metal are well known and are usually related to enzymatic inhibition, elevated ROS production and dysfunction of energy metabolism. Despite that, chronic studies are extremely rare. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.080DOI Listing

E3 ligase ASB8 promotes porcine reproductive and respiratory syndrome virus proliferation by stabilizing the viral Nsp1α protein and degrading host IKKβ kinase.

Virology 2019 Apr 15;532:55-68. Epub 2019 Apr 15.

School of Life Sciences, Tianjin University, Tianjin, 300072, China. Electronic address:

Porcine reproductive and respiratory syndrome virus (PRRSV) can potently suppress type I interferon production and escape from innate immune responses. PRRSV nonstructural protein 1α (Nsp1α) can inhibit IFN-β and NF-κB gene promoter activities, but the precise mechanisms are largely unclear. In this study, we demonstrated that PRRSV Nsp1α interacted with the host E3 ubiquitin ligase ankyrin repeat and SOCS box-containing 8 (ASB8). Read More

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http://dx.doi.org/10.1016/j.virol.2019.04.004DOI Listing

Identification of a human respiratory syncytial virus phosphoprotein domain required for virus-like-particle formation.

Virology 2019 Apr 9;532:48-54. Epub 2019 Apr 9.

Center for Veterinary Health Sciences, Oklahoma State University, 250 McElroy Hall, Stillwater, OK, 74078, USA. Electronic address:

Perceived inefficiency and inadequate knowledge of the human respiratory syncytial virus (hRSV) assembly process present a hurdle for large-scale production of authentic hRSV virus-like particles (VLPs) for vaccine purposes. We previously established that the matrix protein, phosphoprotein (P), and fusion protein carboxy-terminus were sufficient to generate VLPs that resemble filamentous wildtype hRSV. Here, the contribution of P was examined. Read More

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http://dx.doi.org/10.1016/j.virol.2019.04.001DOI Listing

Bavachin attenuates LPS-induced inflammatory response and inhibits the activation of NLRP3 inflammasome in macrophages.

Phytomedicine 2018 Dec 10;59:152785. Epub 2018 Dec 10.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan; Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. Electronic address:

Background: Bavachin is a natural product isolated from Psoralea corylifolia L. that has been applied as a traditional medicine in Asian countries. However, the anti-inflammatory effects of bavachin on LPS-induced inflammation and NLRP3 inflammasome activation by macrophages remain unclear. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.12.008DOI Listing
December 2018

The non-anticoagulant promise of heparin and its mimetics.

Authors:
Barbara Mulloy

Curr Opin Pharmacol 2019 Apr 19;46:50-54. Epub 2019 Apr 19.

Institute of Pharmaceutical Science, King's College London, 150 Stamford Street, London, SE1 9NH, UK. Electronic address:

Heparin, the widely used anticoagulant and antithrombotic polysaccharide, has other potential therapeutic uses that arise from its similarity to heparan sulfate. This review provides a brief overview of the most recent developments in this field, paying particular respect to pulmonary and respiratory pharmacology. It has often been said that heparin, with its mimetics and derivatives, shows great promise in the treatment of inflammatory, infectious, and malignant conditions. Read More

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http://dx.doi.org/10.1016/j.coph.2019.03.009DOI Listing

Propofol improves colonic but impairs hepatic mitochondrial function in tissue homogenates from healthy rats.

Eur J Pharmacol 2019 Apr 19. Epub 2019 Apr 19.

Department of Anaesthesiology, University of Duesseldorf, Moorenstrasse 5, 40225, Duesseldorf, Germany. Electronic address:

Evidence suggests that propofol infusion syndrome (PRIS) is caused by an altered mitochondrial function. The aim of this study was to examine the effects of propofol and the vehicle MCT on mitochondrial function in hepatic and colonic tissue. Mitochondrial oxygen consumption was determined in colon and liver homogenates after incubation with buffer (control), propofol (50, 75, 100, 500 μM) or the carrier substances DMSO and MCT. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.04.031DOI Listing

Co-spray-dried urea cross-linked hyaluronic acid and sodium ascorbyl phosphate as novel inhalable dry powder formulation.

J Pharm Sci 2019 Apr 19. Epub 2019 Apr 19.

Respiratory Technology, Woolcock Institute of Medical Research and Discipline of Pharmacology, Faculty of Medicine and Health, The University of Sydney, 431 Glebe Point Road, Glebe, NSW 2037, Australia. Electronic address:

The pathogenesis and progression of several lung disorders is propagated by inflammatory and oxidative processes which can be controlled by adjunctive inhaled therapies. The present study aimed to develop an inhalable dry powder formulation consisting of co-spray-dried urea-crosslinked hyaluronic acid and sodium ascorbyl phosphate (SD HA-CL - SAP), a novel combination which was recently shown to possess anti-inflammatory, antioxidant and wound healing properties. Native HA and SAP were co-spray dried (SD HA - SAP) and evaluated as control formulation. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.04.015DOI Listing
April 2019
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An Evaluation of Mepolizumab for the Treatment of Severe Asthma.

Expert Opin Biol Ther 2019 Apr 22. Epub 2019 Apr 22.

c Department of Clinical and Experimental Medicine , University of Catania , Catania (CT) , Italy.

Introduction Asthma is considered one of the most common chronic conditions globally, characterized by variable airflow obstruction and symptoms. Severe asthma is diagnosed when asthma control requires high-intensity therapy or continues to remain uncontrolled despite treatment. Eosinophilic inflammation is known to be perpetuated by the activity of IL-5 in a proportion of severe asthma subjects, and targeting IL-5 may offer a therapeutic option. Read More

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https://www.tandfonline.com/doi/full/10.1080/14712598.2019.1
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http://dx.doi.org/10.1080/14712598.2019.1610382DOI Listing
April 2019
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STAT2 dependent Type I Interferon response promotes dysbiosis and luminal expansion of the enteric pathogen Salmonella Typhimurium.

PLoS Pathog 2019 Apr 22;15(4):e1007745. Epub 2019 Apr 22.

Department of Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States of America.

The mechanisms by which the gut luminal environment is disturbed by the immune system to foster pathogenic bacterial growth and survival remain incompletely understood. Here, we show that STAT2 dependent type I IFN signaling contributes to the inflammatory environment by disrupting hypoxia enabling the pathogenic S. Typhimurium to outgrow the microbiota. Read More

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http://dx.plos.org/10.1371/journal.ppat.1007745
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http://dx.doi.org/10.1371/journal.ppat.1007745DOI Listing
April 2019
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Assessment of eight nucleic acid amplification technologies for potential use to detect infectious agents in low-resource settings.

PLoS One 2019 22;14(4):e0215756. Epub 2019 Apr 22.

PATH, Seattle, Washington, United States of America.

Nucleic acid amplification technologies (NAATs) are high-performance tools for rapidly and accurately detecting infectious agents. They are widely used in high-income countries to diagnose disease and improve patient care. The complexities associated with test methods, reagents, equipment, quality control and assurance require dedicated laboratories with trained staff, which can exclude their use in low-resource and decentralized healthcare settings. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215756PLOS

Spatial distribution and determinants of acute respiratory infection among under-five children in Ethiopia: Ethiopian Demographic Health Survey 2016.

PLoS One 2019 22;14(4):e0215572. Epub 2019 Apr 22.

Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Childhood acute respiratory infection remains the commonest global cause of morbidity and mortality among under-five children. In Ethiopia, it remains the highest burden of the health care system. The problem varies in space and time, and exploring its spatial distribution has supreme importance for monitoring and designing effective intervention programs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215572PLOS
April 2019
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A cross-sectional survey on the seroprevalence of dengue fever in febrile patients attending health facilities in Cross River State, Nigeria.

PLoS One 2019 22;14(4):e0215143. Epub 2019 Apr 22.

Nuffield Centre for International Health and Development, University of Leeds, Leeds, United Kingdom.

Background: In Nigeria, recent reports suggest that dengue viruses could be a major cause of acute fevers. We sought to make a cross-sectional estimate of the prevalence of current and previous dengue infections in patients presenting with fever to healthcare centres in Cross River State Nigeria.

Methodology/principal Findings: This cross-sectional health facility survey recruited persons with temperature ≥38°C. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215143PLOS

A small RNA controls bacterial sensitivity to gentamicin during iron starvation.

PLoS Genet 2019 Apr 22;15(4):e1008078. Epub 2019 Apr 22.

Aix Marseille Univ-CNRS, UMR 7243, Laboratoire de Chimie Bactérienne, Institut de Microbiologie de la Méditerranée, Marseille, France.

Phenotypic resistance describes a bacterial population that becomes transiently resistant to an antibiotic without requiring a genetic change. We here investigated the role of the small regulatory RNA (sRNA) RyhB, a key contributor to iron homeostasis, in the phenotypic resistance of Escherichia coli to various classes of antibiotics. We found that RyhB induces phenotypic resistance to gentamicin, an aminoglycoside that targets the ribosome, when iron is scarce. Read More

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http://dx.plos.org/10.1371/journal.pgen.1008078
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http://dx.doi.org/10.1371/journal.pgen.1008078DOI Listing
April 2019
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Exercise-Intensity Adherence During Aerobic Training and Cardiovascular Response During Resistance Training in Cancer Survivors.

J Strength Cond Res 2019 Apr 11. Epub 2019 Apr 11.

GIAFyS Cancer Foundation, Miranda de Ebro, Burgos, Spain.

Quevedo-Jerez, K, Gil-Rey, E, Maldonado-Martín, S, and Herrero-Román, F. Exercise-intensity adherence during aerobic training and cardiovascular response during resistance training in cancer survivors. J Strength Cond Res XX(X): 000-000, 2019-Combined aerobic-resistance training has shown the best benefits has proved beneficial for cancer survivors (CS). Read More

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http://dx.doi.org/10.1519/JSC.0000000000003144DOI Listing

Extent of Ischemic Brain Injury After Thrombotic Stroke Is Independent of the NLRP3 (NACHT, LRR and PYD Domains-Containing Protein 3) Inflammasome.

Stroke 2019 May;50(5):1232-1239

From the Division of Neuroscience and Experimental Psychology (E.L., J.B., G.C., S.M.A., D.B.), School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom.

Background and Purpose- A major process contributing to cell death in the ischemic brain is inflammation. Inflammasomes are multimolecular protein complexes that drive inflammation through activation of proinflammatory cytokines, such as IL (interleukin)-1β. Preclinical evidence suggests that IL-1β contributes to a worsening of ischemic brain injury. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023620DOI Listing

Influence of the Urban Exposome on Birth Weight.

Environ Health Perspect 2019 Apr;127(4):47007

4 Team of environmental epidemiology applied to reproduction and respiratory health, Institut national de la santé et de la recherche médicale (Inserm, National Institute of Health & Medical Research), Institute for Advanced Biosciences (IAB), CNRS, Université Grenoble Alpes , Grenoble, France.

Background: The exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating multiple environmental exposures simultaneously during critical periods of life.

Objective: We evaluated the association of the urban exposome with birth weight. Read More

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http://dx.doi.org/10.1289/EHP3971DOI Listing

Approach to Prioritizing Respiratory Protection When Demand Exceeds Supplies During an Influenza Pandemic: A Call to Action.

Health Secur 2019 Mar/Apr;17(2):152-155

Anita Patel, PharmD, MS, is Senior Advisor, Medical Care and Countermeasures Lead, Influenza Coordination Unit; and Leslie Lee, MPH, is a Public Health Advisor, General Dynamics Information Technology, contracted to the Influenza Coordination Unit; both in the National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, GA. Satish K. Pillai, MD, MPH, is Deputy Director, Division of Preparedness and Emerging Infectious Disease; and Amy L. Valderrama, PhD, RN, is a Nurse Epidemiologist, Division of Healthcare Quality Promotion; both in the National Center for Emerging and Zoonotic Infections Diseases, CDC, Atlanta, GA. Lisa J. Delaney, MS, is Associate Director for Emergency Preparedness and Response, National Institute for Occupational Safety and Health (NIOSH), CDC, Atlanta, GA. Lewis Radonovich, MD, is Chief of Research, National Personal Protective Technology Laboratory, NIOSH, CDC, Pittsburgh, PA. The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. The authors have no conflicts of interest.

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http://dx.doi.org/10.1089/hs.2019.0027DOI Listing

Impact of Hanging Motionless in Harness on Respiratory and Blood Pressure Reflex Modulation in Mountain Climbers.

High Alt Med Biol 2019 Apr 19. Epub 2019 Apr 19.

1 School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

Lanfranconi, Francesca, Alessandra Ferri, Luca Pollastri, Manuela Bartesaghi, Massimiliano Novarina, Giovanni De Vito, Egidio Beretta, and Lucio Tremolizzo. Impact of hanging motionless in harness on respiratory and blood pressure reflex modulation in mountain climbers. 16:000-000, 2019. Read More

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https://www.liebertpub.com/doi/10.1089/ham.2018.0089
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http://dx.doi.org/10.1089/ham.2018.0089DOI Listing
April 2019
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Sapylin inhibits lung cancer cell proliferation and promotes apoptosis by attenuating PI3K/AKT signaling.

J Cell Biochem 2019 Apr 22. Epub 2019 Apr 22.

Department of Respiratory Medicine, Dongying People's Hospital, Dongying, Shandong, China.

Sapylin (OK-432) revealed biological properties in cancers. In this study, the effect of sapylin on lung cancer cell A549 was investigated. A549 cell lines were treated with sapylin (0. Read More

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http://dx.doi.org/10.1002/jcb.28729DOI Listing

Epigenome Wide Association Studies in Asthma: A Systematic Review.

Clin Exp Allergy 2019 Apr 22. Epub 2019 Apr 22.

Department of Bioanalysis, Faculty of pharmaceutical sciences, Ghent University, Ottergemsesteenweg 460, 9000, Ghent.

Objective: Asthma is a common, chronic respiratory airway disease influenced by environmental factors and possibly their interaction with the human genome causing epigenetic changes. Epigenome wide association studies (EWAS) have mainly investigated DNA methylation and its association with disease or traits, exposure factors or gene expression. This systematic review aimed to identify all EWAS assessing differentially methylated sites associated with asthma in humans. Read More

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http://dx.doi.org/10.1111/cea.13403DOI Listing

Effect of Albuterol Premedication vs Placebo on the Occurrence of Respiratory Adverse Events in Children Undergoing Tonsillectomies: The REACT Randomized Clinical Trial.

JAMA Pediatr 2019 Apr 22. Epub 2019 Apr 22.

Telethon Kids Institute, Perth, Australia.

Importance: Tonsillectomy is a common pediatric procedure for the treatment of sleep-disordered breathing and chronic tonsillitis. Up to half of children having this procedure experience a perioperative respiratory adverse event.

Objective: To determine whether inhaled albuterol sulfate (salbutamol sulfate) premedication decreases the risk of perioperative respiratory adverse events in children undergoing anesthesia for tonsillectomy. Read More

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http://dx.doi.org/10.1001/jamapediatrics.2019.0788DOI Listing

Remote Laboratory Management: Respiratory Virus Diagnostics.

J Vis Exp 2019 Apr 6(146). Epub 2019 Apr 6.

Baylor Global Health, Baylor College of Medicine; Department of Medicine, Baylor College of Medicine;

An uptick in recent pandemics (Ebola, Zika, MERS, influenza, etc.) underlines the need for a more 'nimble,' coordinated response that addresses a multitude of issues ranging from transportation, access, facilities, equipment, and communication to provider training. To address this need, we have developed an innovative, scalable, logistics-enhanced, mobile, laboratory facility for emergencies and epidemics in resource-constrained global settings. Read More

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http://dx.doi.org/10.3791/59188DOI Listing

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses.

J Vis Exp 2019 Apr 4(146). Epub 2019 Apr 4.

UMR 1173 Institut national de la santé et de la recherche médicale (INSERM), Université de Versailles St. Quentin; Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Ambroise Paré, Laboratoire de Microbiologie;

The use of recombinant viruses has become crucial in basic or applied virology. Reverse genetics has been proven to be an extremely powerful technology, both to decipher viral replication mechanisms and to study antivirals or provide development platform for vaccines. The construction and manipulation of a reverse genetic system for a negative-strand RNA virus such as a respiratory syncytial virus (RSV), however, remains delicate and requires special know-how. Read More

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http://dx.doi.org/10.3791/59218DOI Listing

Damage control orthopedics applied in an 8-year-old child with life-threatening multiple injuries: A CARE-compliant case report.

Medicine (Baltimore) 2019 Apr;98(16):e15294

University Children's Hospital Basel (UKBB), Department of Pediatric Surgery, 4056 Basel.

Rationale: Damage control is a staged surgical approach to manage polytraumatized patients. The damage control approach comprises three steps. First, bleeding is controlled and fractures are stabilized temporarily; second, vital parameters are stabilized and the child is rewarmed in the intensive care unit; and third, the child is reoperated for definitive repair of injuries. Read More

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http://Insights.ovid.com/crossref?an=00005792-201904190-0005
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http://dx.doi.org/10.1097/MD.0000000000015294DOI Listing
April 2019
2 Reads

Melioidosis, an emerging infectious disease in the Midwest Brazil: A case report.

Medicine (Baltimore) 2019 Apr;98(16):e15235

Graduate Program in Infectious and Parasitic Diseases of Federal University of Mato Grosso do Sul.

Rationale: Melioidosis is an emerging infectious disease in Brazil and caused by Burkholderia pseudomallei, with high morbidity and mortality rates. A total of 28 melioidosis cases were reported in Brazil until 2015. The majority of melioidosis cases were reported in the Northwest region of Brazil and such cases were not previously detected in the Midwest region of Brazil. Read More

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http://dx.doi.org/10.1097/MD.0000000000015235DOI Listing
April 2019
5.723 Impact Factor

Knowledge and attitudes regarding hospice care among outpatients and family members in two hospitals in China.

Medicine (Baltimore) 2019 Apr;98(16):e15230

Research Center of Clinical Epidemiology.

Access to hospice care is widely provided in Western countries, but the supply of such service is still in its initiative stage in China. As relatives are often involved in end-of-life decision making in China, a better understanding of their cognitions toward hospice care would help policy makers and physicians to overcome the barriers of providing such service. Thus, we conducted the study to assess the level of knowledge and attitudes among Chinese outpatients and family members regarding hospice care. Read More

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http://dx.doi.org/10.1097/MD.0000000000015230DOI Listing

Efficacy of rivaroxaban for pulmonary embolism.

Medicine (Baltimore) 2019 Apr;98(16):e15224

Department of Critical Medicine, Yulin No. 2 Hospital, Yulin, Shaanxi, China.

Background: Previous clinical trials have addressed that rivaroxaban is effective for the treatment of patients with pulmonary embolism (PE). This study will systematically assess its efficacy and safety for PE.

Methods: We will carry out this study by searching the following electronic databases from inception to March 1, 2019 without language restrictions: Cochrane Library, EMBASE, PUBMED, Web of Science, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. Read More

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http://dx.doi.org/10.1097/MD.0000000000015224DOI Listing

Tension pneumothorax-induced Takotsubo syndrome: A case report.

Medicine (Baltimore) 2019 Apr;98(16):e15190

Rationale: Takotsubo syndrome (TTS) is a form of acute and usually reversible heart failure syndrome. Transient left ventricular dysfunction and electrocardiographic changes could mimic acute coronary syndrome but there are actually no obstructive coronary lesions.

Patient Concerns: A 76-year-old woman with chronic lung disease developed spontaneous tension pneumothorax with the presentation of severe dyspnea, respiratory failure, left ventricular dysfunction, and anterior wall ST-segment elevation on 12-lead electrocardiogram. Read More

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http://dx.doi.org/10.1097/MD.0000000000015190DOI Listing

Effect of Vasopressors on The Macro- and Microcirculation During Systemic Inflammation In Humans in vivo.

Shock 2019 Apr 16. Epub 2019 Apr 16.

Department of Intensive Care Medicine, Radboud university medical center, Nijmegen, the Netherlands.

Aim: Comparing the effects of different vasopressors in septic shock patients is hampered by high heterogeneity and the fact that current guidelines dictate the use of norepinephrine. Herein, we studied the effects of three vasopressor agents, norepinephrine, phenylephrine and vasopressin, on the macro- and microcirculation during experimental human endotoxemia, a standardized, controlled model of systemic inflammation in humans in vivo.

Methods: We performed a randomized controlled study in which 40 healthy male volunteers were assigned to a five-hour infusion of either 0. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001357DOI Listing

Activating α4β2 Nicotinic Acetylcholine Receptors Alleviates Fentanyl-induced Respiratory Depression in Rats.

Anesthesiology 2019 Apr 16. Epub 2019 Apr 16.

From the Department of Physiology, University of Alberta, Edmonton, Alberta, Canada.

What We Already Know About This Topic: Opioid-induced respiratory depression results in part from direct activation of μ-opioid receptors expressed in the inspiratory rhythm generator located in the ventrolateral medulla, the preBötzinger ComplexRespiratory neurons within the medulla also express nicotinic acetylcholine receptors, which are made up of five subunits, arranged symmetrically around a central poreActivation of the nicotinic acetylcholine receptor α4, α7, and β2 subunits increases respiratory rhythm, whereas activation of the nicotinic acetylcholine receptor α4β2 or α7 subunits induces analgesia in multiple forms of pain WHAT THIS ARTICLE TELLS US THAT IS NEW: The nonselective nicotinic acetylcholine receptor agonist nicotine and the α4β2 nicotinic acetylcholine receptor agonist A85380, but not the α7 nicotinic acetylcholine receptor agonist PNU282987, reversed respiratory depression induced by activation of μ-opioid receptors in rats both in vitro and in vivoCoadministration of A85380 with fentanyl not only markedly reduced respiratory depression and apneas but also enhanced the fentanyl-induced analgesia BACKGROUND:: Opioid analgesics are widely used for treatment of acute, postoperative, and chronic pain. However, activation of opioid receptors can result in severe respiratory depression. There is an unmet clinical need to develop a pharmacologic therapy to counter opioid-induced respiratory depression without interfering with analgesia. Read More

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http://dx.doi.org/10.1097/ALN.0000000000002676DOI Listing

Dexmedetomidine for Electrocorticography in Patients With Lennox-Gastaut Syndrome Presenting for Epilepsy Surgery: A Case Report.

A A Pract 2019 Apr 17. Epub 2019 Apr 17.

From the Division of Neuroanesthesia, Department of Anaesthesiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.

We report the anesthetic management of 2 patients with Lennox-Gastaut syndrome presenting for respective epilepsy surgery with intraoperative electrocorticography. Electrocorticography is a useful tool to guide the localization of the epileptogenic focus for surgical resection in epilepsy surgery. Drug interactions, proconvulsant or anticonvulsant activity of the anesthetics, and anesthetic influence on intraoperative electrocorticography are the primary concerns to be addressed in these patients. Read More

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http://dx.doi.org/10.1213/XAA.0000000000001020DOI Listing
April 2019
1 Read

A major interspecies difference in the ionic selectivity of megakaryocyte Ca-activated channels sensitive to the TMEM16F inhibitor CaCCinh-A01.

Platelets 2019 Apr 22:1-5. Epub 2019 Apr 22.

a Department of Molecular and Cell Biology , University of Leicester , Leicester , UK.

TMEM16F is a surface membrane protein critical for platelet procoagulant activity, which exhibits both phospholipid scramblase and ion channel activities following sustained elevation of cytosolic Ca. The extent to which the ionic permeability of TMEM16F is important for platelet scramblase responses remains controversial. To date, only one study has reported the electrophysiological properties of TMEM16F in cells of platelet/megakaryocyte lineage, which observed cation-selectivity within excised patch recordings from murine marrow-derived megakaryocytes. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2019.1
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http://dx.doi.org/10.1080/09537104.2019.1595560DOI Listing
April 2019
1 Read

Orthopedic and orthodontic management in a patient with DiGeorge Syndrome and Familial Mediterranean Fever: A case report.

Spec Care Dentist 2019 Apr 22. Epub 2019 Apr 22.

Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Aim: The aim of this study is to report the case of the orthopedic and orthodontic treatment in a young patient affected by DiGeorge Syndrome and Familial Mediterranean Fever.

Case Report: An 8-year-old boy with dysmorphic facial features was brought to our observation. Anamnesis revealed signs of fetal respiratory distress, previous surgically removed subdural hematoma, recurrent episodes of fever, arthralgia, polyserositis, hepatosplenomegaly, chronic interstitial nephritis with hypertension, microprotenuria, normocytic anemia, hyperparathyroidism and secondary amyloidosis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/scd.12381
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http://dx.doi.org/10.1111/scd.12381DOI Listing
April 2019
1 Read

[The role of stem cell-derived exosomes in repairing myocardial injury].

Sheng Li Xue Bao 2019 Apr;71(2):205-215

School of Pharmaceutical Sciences of Guangzhou Medical University, Guangdong Key Laboratory of Molecular Target & Clinical Pharmacology, State Key Laboratory of Respiratory Diseases Pharmacology Group, Guangzhou 511436, China.

At present, it is generally believed that the paracrine effect of stem cells in the repair of myocardial injury is one of the important ways for stem cell therapy. Exosomes are phospholipid bilayer-enclosed nanovesicles that secreted by cells under physiological and pathological conditions. Cargo loaded into exosomes including protein, lipids and nucleic acids can be delivered to recipient cells. Read More

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April 2019
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Rapid and Accurate Diagnosis of the Respiratory Disease Pertussis on a Point-of-Care Biochip.

EClinicalMedicine 2019 Feb 5;8:72-77. Epub 2019 Mar 5.

Department of Chemistry and Biochemistry, Biomedical Engineering, Border Biomedical Research Center, Environmental Science and Engineering, University of Texas at El Paso, 500 West University Ave, El Paso, TX 79968, USA.

Background: Pertussis is a highly contagious respiratory disease caused by the bacterium (). The infection is difficult to diagnose especially in underserved or resource-limited areas. We developed a low-cost and instrument-free diagnostic method for rapid and accurate detection of on a point-of-care (POC) testing device. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S25895370193003
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http://dx.doi.org/10.1016/j.eclinm.2019.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469871PMC
February 2019
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Aluminum toxicity to bone: A multisystem effect?

Authors:
Gordon L Klein

Osteoporos Sarcopenia 2019 Mar 15;5(1):2-5. Epub 2019 Feb 15.

Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch, Galveston, TX, USA.

Aluminum (Al) is the third most abundant element in the earth's crust and is omnipresent in our environment, including our food. However, with normal renal function, oral and enteral ingestion of substances contaminated with Al, such as antacids and infant formulae, do not cause problems. The intestine, skin, and respiratory tract are barriers to Al entry into the blood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24055255183017
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http://dx.doi.org/10.1016/j.afos.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453153PMC
March 2019
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First Description of Macrolide-Resistant in Adults with Community-Acquired Pneumonia in Italy.

Biomed Res Int 2019 17;2019:7168949. Epub 2019 Mar 17.

Department of Biomedical Sciences and Human Oncology-Hygiene Section, University of Bari, Piazza G. Cesare 11, 70124 Bari, Italy.

Background: is a common cause of community-acquired pneumonia (CAP). This cross-sectional study aimed to determine the prevalence of macrolide-resistant strains in a convenience series of 234 adult hospitalised and nonhospitalised subjects with a diagnosis of CAP in January 2013 to April 2015 in South Italy.

Methods: Respiratory samples were subjected to real-time PCR. Read More

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http://dx.doi.org/10.1155/2019/7168949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441498PMC

Transoesophageal ultrasound-guided bronchoscopic aspiration of a superior mediastinal tumour using the BF-UC290F instrument.

Respirol Case Rep 2019 Jul 10;7(5):e00427. Epub 2019 Apr 10.

Department of Respiratory Medicine National Hospital Organization Okayama Medical Center Okayama Japan.

A 46-year-old male with a superior mediastinal mass presented with a one-month history of hoarseness and chest pain and was referred to our hospital. Although endobronchial, ultrasound-guided, transbronchial needle aspiration (EBUS-TBNA) was initially performed, we could not obtain an adequate specimen because of his severe cough and an inadequate EBUS view. During the same endoscopic session, we performed endoscopic, ultrasound-guided, bronchoscopic fine-needle aspiration (EUS-B-FNA) via a transoesophageal approach using the BF-UC290F (Olympus, Tokyo, Japan), a third-generation EBUS-TBNA endoscope. Read More

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http://dx.doi.org/10.1002/rcr2.427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457045PMC

Severe mediastinitis over a month after endobronchial ultrasound-guided transbronchial needle aspiration.

Respirol Case Rep 2019 Jul 9;7(5):e00426. Epub 2019 Apr 9.

Department of Respiratory Medicine Juntendo University Graduate School of Medicine Tokyo Japan.

Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been reported to be a minimally invasive and relatively safe procedure, mediastinitis is a serious complication related to the procedure. The median time of mediastinitis onset is approximately 12 days after EBUS-TBNA. Here we report two rare cases with mediastinitis onset 40 and 53 days after EBUS-TBNA. Read More

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http://dx.doi.org/10.1002/rcr2.426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454807PMC

Dyspnoea and restrictive lung disease due to mediastinal and pleural lipomatosis in morbid obesity.

Respirol Case Rep 2019 Jul 9;7(5):e00421. Epub 2019 Apr 9.

Department of Respiratory Medicine Waikato Hospital Hamilton New Zealand.

Dyspnoea in obese patients can be multifactorial and complex. Mediastinal and pleural lipomatosis can be associated with obesity and is usually considered asymptomatic and benign. We report an obese 39-year-old man who presented with progressive dyspnoea, where in addition to obstructive sleep apnoea and obesity hypoventilation syndrome, was found to have massive mediastinal and pleural lipomatosis causing restrictive lung disease. Read More

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http://dx.doi.org/10.1002/rcr2.421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454808PMC

Early Recognition of Acute Pneumonitis in Amiodarone Treatment.

Heart Views 2018 Jul-Sep;19(3):109-113

Department of Pulmonology, Alexis Multispeciality Hospital, Nagpur, Maharashtra, India.

Pulmonary complications of long-term amiodarone use are well known. However, acute pneumonitis causing respiratory distress with short-term administration of amiodarone although rare is associated with high mortality. Early diagnosis and treatment with glucocorticoids significantly decrease associated mortality and morbidity. Read More

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http://dx.doi.org/10.4103/HEARTVIEWS.HEARTVIEWS_22_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448471PMC

[Spontaneous pneumomediastinum: about 18 cases].

Pan Afr Med J 2018 2;31:75. Epub 2018 Oct 2.

Centre Hospitalier Universitaire Ibn Rochd de Casablanca, Maroc.

Spontaneous pneumomediastinum is defined as the presence of air in the mediastinum in the absence of traumatic or iatrogenic cause. Diagnosis is based on chest X-ray. Other paraclinical examinations, such as chest tomodensitometry or bronchial or gastrointestinal endoscopy, are sometimes necessary. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.75.15737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457723PMC
October 2018

Influenza A H1N1 Community-Acquired Pneumonia: Characteristics and Risk Factors-A Case-Control Study.

Can Respir J 2019 17;2019:4301039. Epub 2019 Mar 17.

Service of Pneumology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain.

Introduction: Influenza A H1N1 community-acquired pneumonia (CAP) is a quite frequent respiratory disease. Despite being considered more serious than other CAPs, there are very few studies comparing its characteristics with noninfluenza CAP. We aim to establish the differences between pneumonia due to H1N1 virus and pneumonia not caused by H1N1 influenza virus and to determine the probability that a pneumonia is due to an H1N1 virus infection based on the most relevant variables. Read More

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http://dx.doi.org/10.1155/2019/4301039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441515PMC

Medical thoracoscopy for tuberculous pleurisy: A retrospective analysis of 575 cases.

Ann Thorac Med 2019 Apr-Jun;14(2):134-140

Department of Respiratory Medicine, Provincial Hospital Affiliated to Shandong University, Shandong, People's Republic of China.

Objective: The objective of this retrospective study was to assess the efficacy of medical thoracoscopy in diagnosing of tuberculous pleurisy and characterize tuberculous pleurisy with medical thoracoscopy.

Methods: A total of 575 patients with tuberculous pleurisy who underwent medical thoracoscopy were included in the study. Demographic data, clinical manifestations, and routine and biochemical tests on pleural fluid, cultures of pleural fluid, sputum, and pleural biopsy for the detection of and pathological findings were evaluated. Read More

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http://dx.doi.org/10.4103/atm.ATM_359_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467019PMC

Sarcoidosis in the Middle East.

Ann Thorac Med 2019 Apr-Jun;14(2):106-115

College of Medicine and Health Science, Sultan Qaboos University, Muscat, Oman.

Sarcoidosis, a systemic granulomatous disease of unknown cause, has been described worldwide and in all populations with notable differences in clinical characteristics, organ involvement, disease severity, and prognosis among different ethnic and racial groups. While the exact prevalence of sarcoidosis in the Middle East is unknown, studies from various countries in the region have reported the clinical characteristics of affected patients, along with a few anecdotal reports. A search of the MEDLINE and Google Scholar databases was conducted for relevant English-language articles using the terms "sarcoidosis" and "Middle East" or "sarcoidosis" and "Arabs. Read More

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http://www.thoracicmedicine.org/text.asp?2019/14/2/106/25551
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http://dx.doi.org/10.4103/atm.ATM_227_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467024PMC
April 2019
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Dexmedetomidine versus fentanyl added to bupivacaine for epidural analgesia in combination with general anesthesia for elective lumbar disc operations: A prospective, randomized double-blinded study.

Saudi J Anaesth 2019 Apr-Jun;13(2):119-125

Department of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Background: The literature on drugs used for combined general anesthesia and epidural analgesia (CGE) in lumbar operations is scarce. The purpose of the study was to compare the addition of either dexmedetomidine or fentanyl to bupivacaine for epidural analgesia in combination with general anesthesia with regard to efficacy and adverse events in such operations.

Materials And Methods: This prospective, randomized, double-blinded study was conducted on 80 patients who were scheduled for an elective lumbar disc operation, age 20-65 years, of either sex and American Society of Anesthesiologists physical status I or II. Read More

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http://dx.doi.org/10.4103/sja.SJA_600_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448444PMC

An overview of the National Microbiology Laboratory emergency management program.

Authors:
D Marcino K Gordon

Can Commun Dis Rep 2018 May 3;44(5):102-105. Epub 2018 May 3.

National Microbiology Laboratory, Public Health Agency of Canada, WinnipegMB.

The National Microbiology Laboratory (NML) emergency management program was developed after the 2003 Severe Acute Respiratory Syndrome (SARS) outbreak to provide a framework for the responses to public health events. The program comprises three components (Site response, Continuity and Site support) that have adopted the Incident Command System (ICS) as their management structure and follows the four phases of emergency management. All program components have extensive competency-based training for staff and exercise plans. Read More

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