582,976 results match your criteria Respiratory Medicine: COPD Update [Journal]


Hospitalization for Respiratory Syncytial Virus Bronchiolitis in the Palivizumab Prophylaxis Era: Need for Reconsideration of Preventive Timing and Eligibility.

Isr Med Assoc J 2019 Feb;21(2):110-115

Department of Pediatrics A, Schneider Children's Medical Center, Petah Tikva, Israel.

Background: Respiratory syncytial virus (RSV)-related bronchiolitis is a common cause of morbidity in young infants. The recommendations for its passive prevention by palivizumab are currently under intensive debate.

Objectives: To elucidate the optimal prevention strategy by studying the morbidity of RSV disease under the current recommendations for palivizumab prophylaxis in Israel. Read More

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February 2019

Contemporary Concise Review 2018: Lung cancer and pleural disease.

Respirology 2019 Feb 16. Epub 2019 Feb 16.

Department of Respiratory Medicine, Royal Brompton Hospital, London, UK.

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http://dx.doi.org/10.1111/resp.13499DOI Listing
February 2019

[Successful Use of Percutaneous Left Ventricular Assist Device( Impella) and Veno Artery Extracorporeal Membrane Oxygenation( VA-ECMO) for Ischemic Cardiogenic Shock;Report of a Case].

Kyobu Geka 2019 Feb;72(2):120-123

Department of Cardiovascular Surgery, Nagoya Tokushukai General Hospital, Kasugai, Japan.

A 73-year-old male was referred to our hospital for acute congestive heart failure. His cardiac and respiratory conditions were worsening with cardiogenic shock requiring intubation. Coronary angiography revealed severe triple vessel disease, and echocardiography showed severe left ventricular dysfunction. Read More

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February 2019

Medical management of acute upper respiratory infections in an urban primary care out-of-hours facility: cross-sectional study of patient presentations and expectations.

BMJ Open 2019 Feb 15;9(2):e025396. Epub 2019 Feb 15.

Graduate Entry Medical School, University of Limerick Faculty of Education and Health Sciences, Limerick, Ireland.

Objectives: The purpose of this study was to examine the expectations of patients attending an urban primary care out-of-hours (OOH) facility with acute upper respiratory tract infection (acute URTI) regarding clinical examination, symptom management, information on their condition, reassurance, antibiotic treatment and other possible options including referral.

Design: Cross-sectional design.

Setting: One urban primary care OOH facility located in the midwest of Ireland. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025396DOI Listing
February 2019

Burden of non-accidental mortality attributable to ambient temperatures: a time series study in a high plateau area of southwest China.

BMJ Open 2019 Feb 15;9(2):e024708. Epub 2019 Feb 15.

Department of Preventive Medicine, Shantou University Medical College, Shantou, China.

Objective: To examine the total non-accidental mortality burden attributable to ambient temperatures and assess the effect modification of the burden by specific causes of death and individual characteristics in a high plateau area in southwest China.

Methods: Using daily mortality and meteorological data from 2009 to 2016, we applied a quasi-Poisson model combined with a distributed lag non-linear model to estimate the temperature-mortality association with the assessment of attributable fraction and number. We calculated attributable fractions and deaths with 95% empirical CIs (eCIs), that were due to cold and heat, defined as temperatures below and above the median temperature, and for mild and extreme temperatures, defined by cut-offs at the 2. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024708DOI Listing
February 2019

The antagonistic effect of Se on the Pb-weakening formation of neutrophil extracellular traps in chicken neutrophils.

Ecotoxicol Environ Saf 2019 Feb 14;173:225-234. Epub 2019 Feb 14.

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China. Electronic address:

Neutrophils represent an important part of the body's innate immunity and can resist the invasion of pathogenic microorganisms by releasing neutrophil extracellular traps (NETs). In this study, we investigated the toxic effects of lead (Pb) on the release of NETs, the antagonism of selenium (Se) on Pb toxicity and the potential molecular mechanisms. Our model was an in vitro exposure model for the addition of Se, Pb or both in the culture medium and was based on the separation of neutrophils from the peripheral blood of healthy chickens. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.033DOI Listing
February 2019

Acute Respiratory Illness in Rural Haiti.

Int J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA; Department of Health Services Research, Management and Policy, College of Public Health and Health Professions, University of Florida, Gainesville, FL. USA.

Objectives: Acute Respiratory Infection (ARI) is the most common cause of childhood morbidity and mortality in developing countries, including Haiti. Our objective was to detect pathogens found in children with ARI in rural Haiti to help develop evidence-based guidelines for treatment and prevention.

Methods: Retrospective study of students with ARI at four schools in rural Haiti. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.003DOI Listing
February 2019

Effects of an Attachment-Based Intervention in Infancy on Children's Autonomic Regulation during Middle Childhood.

Biol Psychol 2019 Feb 14. Epub 2019 Feb 14.

Department of Psychological and Brain Sciences, University of Delaware, United States.

The present study used a longitudinal randomized clinical trial to test whether an early intervention has causal effects on children's autonomic nervous system regulation. When children were infants, parents involved with Child Protective Services received Attachment and Biobehavioral Catch-up (ABC; N = 43), an intervention that promotes sensitive parenting, or a control intervention (N = 53). When children were 9 years old, children whose parents had received ABC exhibited higher respiratory sinus arrhythmia and lower heart rate at rest and during a parent-child interaction than children in the control group. Read More

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http://dx.doi.org/10.1016/j.biopsycho.2019.01.006DOI Listing
February 2019

Drug Induced Enterocolitis Syndrome (DIES): a clinical entity which deserves more awareness.

Ann Allergy Asthma Immunol 2019 Feb 14. Epub 2019 Feb 14.

Erasmus MC University Medical Center, Department of Pediatrics, division of Respiratory Medicine and Allergology, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.anai.2019.02.004DOI Listing
February 2019

Routine monitoring with pleural manometry during therapeutic large-volume thoracentesis to prevent pleural-pressure-related complications: a multicentre, single-blind randomised controlled trial.

Lancet Respir Med 2019 Feb 13. Epub 2019 Feb 13.

Departments of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Thoracic Surgery, Vanderbilt University School of Medicine, Nashville, TN, USA. Electronic address:

Background: In patients with non-expandable lung, removal of pleural fluid can result in excessively negative pleural pressure, which is associated with chest discomfort, pneumothorax, and re-expansion pulmonary oedema. Pleural manometry is widely used to safeguard against pressure-related complications during thoracentesis despite little evidence to support the approach. We investigated whether monitoring of pleural pressure with manometry during thoracentesis could protect against complications compared with assessment of symptoms alone. Read More

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http://dx.doi.org/10.1016/S2213-2600(18)30421-1DOI Listing
February 2019

Low starting-dosage of nintedanib for the reduction of early termination.

Respir Investig 2019 Feb 13. Epub 2019 Feb 13.

Kanagawa Cardiovascular and Respiratory Center, Department of Respiratory Medicine, Tomioka-Higashi 6-16-1, Kanazawa-ku, Yokohama 236-0051, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.resinv.2018.12.010DOI Listing
February 2019

Teaching inhalation technique in COPD outpatients: Can a sustained improvement be achieved?

Pulmonology 2019 Feb 13. Epub 2019 Feb 13.

Horizonte Family Health Unit, Matosinhos, Portugal; ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.

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http://dx.doi.org/10.1016/j.pulmoe.2018.11.006DOI Listing
February 2019

Do patients with cystic fibrosis participating in clinical trials demonstrate placebo response? A meta-analysis.

J Cyst Fibros 2019 Feb 13. Epub 2019 Feb 13.

UMR 5558 CNRS, Equipe EMET, Université Claude Bernard Lyon 1, Lyon, France; Centre de ressources et de compétences de la mucoviscidose, Hospices Civils de Lyon, Lyon, France. Electronic address:

Background: Patients' and families' expectation that a cure for cystic fibrosis (CF) will be found is high. In other debilitating conditions, high expectation has been shown to drive a strong placebo response (PR). Therefore, our goal was to evaluate PR on objective continuous outcomes (FEV, BMI) and the CF Questionnaire Revised-Respiratory Domain (CFQR-RD) monitored during randomised clinical trials (RCTs) for CF. Read More

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http://dx.doi.org/10.1016/j.jcf.2019.02.003DOI Listing
February 2019

Medication-related risk factors and its association with repeated hospital admissions in frail elderly: A case control study.

Res Social Adm Pharm 2019 Feb 13. Epub 2019 Feb 13.

University of Bradford, School of Pharmacy and Medical Sciences, Bradford, UK.

Background: Repeated hospital admissions are prevalent in older people. The role of medication in repeated hospital admissions has not been widely studied. The hypothesis that medication-related risk factors for initial hospital admissions were also associated with repeated hospital admissions was generated. Read More

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http://dx.doi.org/10.1016/j.sapharm.2019.02.001DOI Listing
February 2019

Workplace Smoke-Free Policies and Cessation Programs Among U.S. Working Adults.

Am J Prev Med 2019 Feb 14. Epub 2019 Feb 14.

Respiratory Health Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia.

Introduction: Workplace tobacco control interventions reduce smoking and secondhand smoke exposure among U.S. workers. Read More

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http://dx.doi.org/10.1016/j.amepre.2018.10.030DOI Listing
February 2019

Prenatal diagnosis and management of congenital diaphragmatic hernia.

Best Pract Res Clin Obstet Gynaecol 2019 Jan 5. Epub 2019 Jan 5.

Academic Department of Development and Regeneration, Cluster Woman and Child, Biomedical Sciences, KU Leuven, Belgium; Clinical Department of Obstetrics & Gynaecology, KU Leuven, Leuven, Belgium; Institute for Women's Health, University College London, London, UK; European Reference Network on Rare and Inherited Congenital Anomalies "ERNICA". Electronic address:

Congenital diaphragmatic hernia is characterized by failed closure of the diaphragm, thereby allowing abdominal viscera to herniate into the thoracic cavity and subsequently interfering with normal lung development. At birth, pulmonary hypoplasia leads to respiratory insufficiency and persistent pulmonary hypertension (PHT), that is lethal in up to 32% of patients. In isolated cases, the outcome may be predicted prenatally by medical imaging and advanced genetic testing. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2018.12.010DOI Listing
January 2019

A Novel Approach to Detect Programed Death Ligand 1 (PD-L1) Status and Multiple Tumor Mutations Using a Single Non-Small-Cell Lung Cancer (NSCLC) Bronchoscopy Specimen.

J Mol Diagn 2019 Feb 8. Epub 2019 Feb 8.

School of Health & Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia. Electronic address:

Multiple biomarkers are under evaluation to guide the use of immune checkpoint inhibitors in non-small-cell lung cancer (NSCLC), including programed death ligand 1 (PD-L1) tumor cell staining. We have developed a new approach that accurately quantifies PD-L1 status and identifies multiple mutations by using a single bronchoscopy specimen. A novel molecular marker was identified to detect the presence of malignant cells in radial endobronchial ultrasound bronchial brushings from NSCLC (n = 15) and benign (n = 13) nodules by quantitative real-time RT-PCR (RT-qPCR). Read More

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http://dx.doi.org/10.1016/j.jmoldx.2018.10.001DOI Listing
February 2019

Abatacept initiation in rheumatoid arthritis and the risk of serious infection: A population-based cohort study.

Semin Arthritis Rheum 2019 Jan 25. Epub 2019 Jan 25.

Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, 3755 Cote Ste-Catherine, H-461 Montreal, Québec H3T 1E2, Canada; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Québec, Canada. Electronic address:

Objective: To assess whether abatacept as initial biologic disease-modifying antirheumatic drug (DMARD) in the treatment of rheumatoid arthritis is associated with an increased risk of serious infections, including bone and joint, gastrointestinal, respiratory tract, skin and soft tissue, and urinary tract, when compared with other biologic DMARDs.

Methods: We performed a population-based cohort study among patients newly-treated with biologic DMARDs within the US-based Truven MarketScan® population and Supplemental US Medicare from 2007 to 2014. Cox proportional hazards models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of serious infections requiring hospitalisation associated with initiation of abatacept, compared with initiation of other bDMARDs, after controlling for age and deciles of the propensity score. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.01.009DOI Listing
January 2019

A register-based study on associations between vaccination, antimicrobial use and productivity in conventional Danish finisher pig herds during 2011 to 2014.

Prev Vet Med 2019 Mar 18;164:33-40. Epub 2019 Jan 18.

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Grønnegårdsvej 8, 1870 Frederiksberg C, Denmark; Danish Agriculture & Food Council, Agro Food Park 13, 8200 Aarhus N, Denmark.

Reduction of antimicrobial use (AMU) in pigs is a priority to counteract development of antimicrobial resistance in animal and human pathogens. However, there is concern that Danish pig producers complying with official AMU restrictions might experience reduced herd health and productivity in the future, if alternative strategies are not available. Vaccination has been suggested as a strategy to prevent disease and minimise the need for antimicrobial treatments. Read More

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http://dx.doi.org/10.1016/j.prevetmed.2019.01.007DOI Listing

Safety issues with the ALK inhibitors in the treatment of NSCLC: A systematic review.

Crit Rev Oncol Hematol 2019 Feb 1;134:56-64. Epub 2018 Dec 1.

Clinical Oncology Department, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt.

Introduction: Oral tyrosine kinase inhibitors targeting the chromosomal rearrangements of the anaplastic lymphoma kinase gene (ALK) in non-small cell lung cancer (NSCLC) were associated with superior clinical outcome. Tyrosine Kinase inhibitors (TKIs) are known to have peculiar toxicity profile, hence, increasing awareness to the safety profile of ALK inhibitors is essential.

Methods: A comprehensive systematic review of literature has been conducted to include prospective trials that used the ALK inhibitors Crizotinib, Ceritinib, Alectinib, Brigatinib and Lorlatinib in patients with advanced NSCLC and have available efficacy and toxicity results. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2018.11.004DOI Listing
February 2019

ICU readmission of patients with cancer: Incidence, risk factors and mortality.

J Crit Care 2019 Feb 7;51:84-87. Epub 2019 Feb 7.

Department of Medicine, Section of Pulmonary and Critical Care, King Hussein Cancer Center, Jordan. Electronic address:

Purpose: Few studies evaluated ICU readmission in cancer patients. This study aimed to describe the incidence and risk factors for ICU readmission in cancer patients and the association with mortality.

Materials And Methods: A retrospective cohort study at a comprehensive cancer center, which included cancer patients who were discharged after their initial ICU admission over a 5-year period. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.008DOI Listing
February 2019

Unfractionated Heparin Alleviates Sepsis-Induced Acute Lung Injury by Protecting Tight Junctions.

J Surg Res 2019 Feb 13;238:175-185. Epub 2019 Feb 13.

Department of Critical Care Medicine, The First Affiliated Hospital, China Medical University, Shenyang, People's Republic of China. Electronic address:

Background: Unfractionated heparin (UFH) has been shown to ameliorate lung edema and lung vascular leakage in lipopolysaccharide-induced lung injury. Impaired tight junction (TJ) function is a sign of sepsis-induced acute respiratory distress syndrome (ARDS) and acute lung injury (ALI), which is closely related to the downregulated expression of TJ-specific proteins or the upregulated expression of inflammatory cytokines. Because UFH has been intensively studied in modulating inflammation, we hypothesize that UFH may play a positive role in treating sepsis-induced ARDS/ALI by protecting TJs. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.020DOI Listing
February 2019

TFAP2C-Activated MALAT1 Modulates the Chemoresistance of Docetaxel-Resistant Lung Adenocarcinoma Cells.

Mol Ther Nucleic Acids 2019 Jan 18;14:567-582. Epub 2019 Jan 18.

Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu 210002, China. Electronic address:

Chemoresistance remains a great obstacle in effective lung adenocarcinoma (LUAD) treatment. Previously, we verified the role of microRNA-200b (miR-200b) in the formation of docetaxel (DTX)-resistant LUAD cells. This study aims to investigate the mechanism underlying the low level of miR-200b in DTX-resistant LUAD cells. Read More

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http://dx.doi.org/10.1016/j.omtn.2019.01.005DOI Listing
January 2019

The first case report of bilateral spontaneous otogenic pneumocephalus.

World Neurosurg 2019 Feb 13. Epub 2019 Feb 13.

Dep. of Neurosurgery and Neurooncology, Charles University in Prague, 1st Medical Faculty, Central Military Hospital Stresovice, Czech Republic. Electronic address:

Background: Pneumocephalus is commonly associated with cranial trauma including surgical interventions. Spontaneous pneumocephalus on the other hand is a rare diagnosis. Reported cases were predominantly unilateral. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.232DOI Listing
February 2019

FMRpolyG alters mitochondrial transcripts level and respiratory chain complex assembly in Fragile X associated tremor/ataxia syndrome [FXTAS].

Biochim Biophys Acta Mol Basis Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemistry, Faculty of Science, The M.S. University of Baroda, Vadodara 390002, Gujarat, India. Electronic address:

Fragile X-associated tremor/ataxia syndrome (FXTAS) is an inherited neurodegenerative disorder caused by an expansion of 55 to 200 CGG repeats (premutation) in FMR1. These CGG repeats are Repeat Associated non-ATG (RAN) translated into a small and pathogenic protein, FMRpolyG. The cellular and molecular mechanisms of FMRpolyG toxicity are unclear. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.010DOI Listing
February 2019

Velogenic newcastle disease virus tissue tropism and pathogenesis of infection in chickens by application of in situ PCR, immunoperoxase staining and HE staining.

Microb Pathog 2019 Feb 13. Epub 2019 Feb 13.

Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.

Limited deep studies are available in the field of early stages of pathogenesis of Newcastle disease virus (NDV) infection and tissue tropism of NDV. In this study, 24 specific pathogen free (SPF) chickens of white leghorn breed were infected with Newcastle disease (ND) by intranasal administration of 10⁵ 50% EID50/0.1 mL of velogenic NDV (vNDV). Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.017DOI Listing
February 2019

A Two-Amino Acid Mutation in Murine IgA Enables Downstream Processing and Purification on Staphylococcal Superantigen-Like Protein 7.

J Biotechnol 2019 Feb 13. Epub 2019 Feb 13.

Ghent University, Department of Plant Biotechnology and Bioinformatics, VIB Center for Plant Systems Biology, 9052 Ghent, Belgium; Instituto de Biología Molecular y Celular de Plantas (IBMCP), Consejo Superior de Investigaciones Científicas (CSIC), Universidad Politécnica de Valencia, Camino de Vera s/n, 46022 Valencia, Spain. Electronic address:

With few exceptions, all currently marketed antibody therapeutics are IgG molecules. One of the reasons that other antibody isotypes are less developed are the difficulties associated with their purification. While commercial chromatography affinity resins like staphylococcal superantigen-like 7 (SSL7) protein containing resin, allow purification of IgAs from many animal species, these are not useful for murine IgAs. Read More

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http://dx.doi.org/10.1016/j.jbiotec.2019.01.020DOI Listing
February 2019

Development of a sandwich enzyme-linked immunosorbent assay for the quantification of ponatinib in serum.

Anal Biochem 2019 Feb 13. Epub 2019 Feb 13.

Applied Life Science Department, Faculty of Biotechnology and Life Science, Sojo University, 4-22-1 Ikeda, Kumamoto, 860-0082, Japan.

The tyrosine kinase inhibitor ponatinib is extensively metabolized in the body, and consequently the development of specific immunoassays for pharmacokinetic studies and therapeutic drug monitoring of ponatinib is challenging. If two antibodies simultaneously recognize the entire structure of ponatinib, they could be utilized to establish an ultra-specific sandwich immunoassay for ponatinib, free of any interference from ponatinib metabolites. In this study, we created two types of anti-ponatinib polyclonal antibodies that recognize two different ponatinib epitopes, and sandwiched almost all structural components of ponatinib in these two antibodies in order to develop an enzyme-linked immunosorbent assay (ELISA) technique not affected by any ponatinib metabolites. Read More

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http://dx.doi.org/10.1016/j.ab.2019.02.010DOI Listing
February 2019
1 Read

Fluctuations of the intraocular pressure in medically versus surgically treated glaucoma patients by a contact lens sensor.

Am J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Translational Research in Respiratory Medicine; Arnau de Vilanova-Santa María University Hospital; IRBLleida, Catalonia, Spain.

Purpose: To compare fluctuations in intraocular pressure (IOP) in medically versus surgically treated glaucoma patients.

Design: Prospective, non-randomized case series.

Methods: IOP-related fluctuations were measured for 24 hours using a contact lens sensor (CLS). Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.003DOI Listing
February 2019
1 Read

Academic achievement of adolescents with asthma or atopic disease.

Clin Exp Allergy 2019 Feb 16. Epub 2019 Feb 16.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Background: Over a fifth of children and adolescents suffer with asthma or atopic disease. It is unclear whether asthma impacts academic performance in children and adolescents, and little is known about the association of eczema, food allergy or hay fever and academic performance.

Objective: To examine whether asthma, eczema, food allergy or hay fever impacts on adolescent academic performance and to assess the role of unmeasured confounding. Read More

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http://dx.doi.org/10.1111/cea.13371DOI Listing
February 2019

Regional pulmonary effects of bronchoalveolar lavage procedure determined by electrical impedance tomography.

Intensive Care Med Exp 2019 Feb 15;7(1):11. Epub 2019 Feb 15.

Pediatric and Neonatal Intensive Care Unit, Children's Hospital, University of Geneva, Geneva, Switzerland.

Background: The provision of guidance in ventilator therapy by continuous monitoring of regional lung ventilation, aeration and respiratory system mechanics is the main clinical benefit of electrical impedance tomography (EIT). A new application was recently described in critically ill patients undergoing diagnostic bronchoalveolar lavage (BAL) with the intention of using EIT to identify the region where sampling was performed. Increased electrical bioimpedance was reported after fluid instillation. Read More

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http://dx.doi.org/10.1186/s40635-019-0225-6DOI Listing
February 2019

Microarray Immunodiagnostics for Aeroallergens.

Curr Allergy Asthma Rep 2019 Feb 15;19(1):10. Epub 2019 Feb 15.

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy.

Purpose Of Review: The impact of new technologies, especially multiplexed molecular allergy diagnostics based on allergen arrays, on the management of complex patients with respiratory allergies has been important.

Recent Findings: Currently, the detailed characteristics of the IgE profile of the patient, such as sensitization to genuine or cross-reacting components or the sensitization to potentially harmful allergens, allow an allergist to tailor treatment in the context of precision medicine rules. A number of relevant articles have been published in recent years on this topic, and, in this review, the new added values of allergen array-based diagnostics are reported. Read More

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http://dx.doi.org/10.1007/s11882-019-0832-zDOI Listing
February 2019

Investigation of Urinary Sestrin2 in Patients with Obstructive Sleep Apnea.

Lung 2019 Feb 15. Epub 2019 Feb 15.

Department of Respiratory and Critical Care Medicine, First Affiliated Hospital, Kunming Medical University, Kunming, China.

Background: Obstructive sleep apnea (OSA) is a disease seriously threatening individual health, which results in serious complications such as hypertension and stroke. These complications are associated with oxidative stress triggered by intermittent hypoxia in OSA. Sestrin2 is a crucial factor involved in oxidative stress. Read More

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http://dx.doi.org/10.1007/s00408-019-00205-8DOI Listing
February 2019

Use of very low tidal volumes during high-frequency ventilation reduces ventilator lung injury.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Medical and Surgical Research Unit, Instituto de Investigación Sanitaria Puerta de Hierro, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.

The use of volume guarantee (VG) on high-frequency oscillatory ventilation (HFOV) allows to use fixed very low high-frequency tidal volume (VThf), maintaining adequate CO removal while potentially reducing the risk of ventilator-induced lung injury.

Objective: To demonstrate that the use of very low VThf can be protective compared with standard VThf on HFOV combined with VG in a neonatal animal model.

Study Design: Experimental study in 2-day-old piglets with induced respiratory distress syndrome ventilated with two different HFOV strategies combined with VG (10 Hz with high VThf versus 20 Hz with very low VThf at similar PaCO). Read More

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http://dx.doi.org/10.1038/s41372-019-0338-5DOI Listing
February 2019

Maternal preeclampsia and respiratory outcomes in extremely premature infants.

Pediatr Res 2019 Feb 15. Epub 2019 Feb 15.

Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA.

Background: Preeclampsia (PE) is a pregnancy complication characterized by an anti-angiogenic environment. This can affect fetal pulmonary vascular and alveolar development but data of the impact of PE on respiratory outcome in extremely premature infants are inconclusive.

Objective: To determine if PE is associated with an increased risk for severe respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) in extremely premature infants. Read More

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http://dx.doi.org/10.1038/s41390-019-0336-5DOI Listing
February 2019
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Understanding skin absorption of common aldehyde vapours from exposure during hazardous material incidents.

J Expo Sci Environ Epidemiol 2019 Feb 15. Epub 2019 Feb 15.

Emergency Response TIPS, LLC, Alexandria, VA, USA.

The toxic release of aldehyde vapours during a hazardous material (HAZMAT) incident primarily results in respiratory concerns for the unprotected public. However, skin absorption may be an important concurrent exposure route that is poorly understood for this scenario. This study provides experimental data on the skin absorption properties of common aldehydes used in industry, including acetaldehyde, acrolein, benzaldehyde and formaldehyde, in gaseous or vapour form using an adapted in vitro technique. Read More

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http://dx.doi.org/10.1038/s41370-019-0127-4DOI Listing
February 2019

Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms.

Nat Commun 2019 Feb 15;10(1):762. Epub 2019 Feb 15.

Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.

Antibiotic efficacy can be antagonized by bioactive metabolites and other drugs present at infection sites. Pseudomonas aeruginosa, a common cause of biofilm-based infections, releases metabolites called phenazines that accept electrons to support cellular redox balancing. Here, we find that phenazines promote tolerance to clinically relevant antibiotics, such as ciprofloxacin, in P. Read More

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http://dx.doi.org/10.1038/s41467-019-08733-wDOI Listing
February 2019

Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function.

Nat Commun 2019 Feb 15;10(1):779. Epub 2019 Feb 15.

Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, 27710, USA.

Influenza B virus (IBV) is an acute, respiratory RNA virus that has been assumed to induce the eventual death of all infected cells. We and others have shown however, that infection with apparently cytopathic viruses does not necessarily lead to cell death; some cells can intrinsically clear the virus and persist in the host long-term. To determine if any cells can survive direct IBV infection, we here generate a recombinant IBV capable of activating a host-cell reporter to permanently label all infected cells. Read More

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http://dx.doi.org/10.1038/s41467-019-08617-zDOI Listing
February 2019

Identification of differentially expressed proteins in the injured lung from zinc chloride smoke inhalation based on proteomics analysis.

Respir Res 2019 Feb 15;20(1):36. Epub 2019 Feb 15.

Department of Respiratory, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.

Background: Lung injury due to zinc chloride smoke inhalation is very common in military personnel and leads to a high incidence of pulmonary complications and mortality. The aim of this study was to uncover the underlying mechanisms of lung injury due to zinc chloride smoke inhalation using a rat model.

Methods: Histopathology analysis of rat lungs after zinc chloride smoke inhalation was performed by using haematoxylin and eosin (H&E) and Mallory staining. Read More

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http://dx.doi.org/10.1186/s12931-019-0995-0DOI Listing
February 2019

Epidemiology of influenza in pregnant women hospitalized with respiratory illness in Moscow, 2012/2013-2015/2016: a hospital-based active surveillance study.

BMC Pregnancy Childbirth 2019 Feb 15;19(1):72. Epub 2019 Feb 15.

Ministry of Health of the Russian Federation, FSBI "N.F. Gamaleya NRCEM", 16, Gamaleya str, Moscow, Russia Moscow, 123098, Russian Federation.

Background: To better understand the impact of seasonal influenza in pregnant women we analyzed data collected during four seasons at a hospital for acute respiratory infection that specializes in treating pregnant women.

Methods: This was a single-center active surveillance study of women 15-44 years of age hospitalized for acute respiratory diseases between 2012/2013 and 2015/2016 in Moscow, Russian Federation. Women had to have been hospitalized within 7 days of the onset of symptoms. Read More

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http://dx.doi.org/10.1186/s12884-019-2192-zDOI Listing
February 2019

Development and validation of the European QUALity (EQUAL) score for mucormycosis management in haematology.

J Antimicrob Chemother 2019 Feb 15. Epub 2019 Feb 15.

Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne, Cologne, Germany.

Background: Mucormycosis is a life-threatening infection in immunocompromised patients and in haematological malignancy patients in particular.

Objectives: Our aim was to develop and evaluate a scoring tool to measure adherence to current guidelines for mucormycosis.

Methods: Current guidelines of scientific societies on mucormycosis management were reviewed. Read More

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http://dx.doi.org/10.1093/jac/dkz051DOI Listing
February 2019

[Integration of Micro Sensors with Mobile Devices for Monitoring Vital Signs of Sleep Apnea Patients].

Zhongguo Yi Liao Qi Xie Za Zhi 2019 Jan;43(1):29-31

Wenzhou Central Hospital, Wenzhou, 325000.

This paper demonstrates a BSN-based portable monitor integrating micro sensors with mobile devices for monitoring and diagnosing obstructive sleep apnea syndrome (OSAS) at home. The system uses a micro hot-film flow sensor to detect respiratory flow, uses tri-axis micro accelerometer to detect body posture and motion intensity, and uses a micro photoelectric sensor to detect oxygen saturation of blood. The real-time vital signs are detected and transmitted wirelessly to a mobile device. Read More

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http://dx.doi.org/10.3969/j.issn.1671-7104.2019.01.008DOI Listing
January 2019

Epidemiological investigation and phylogenetic analysis of Caprine parainfluenza virus type 3 in sheep of China.

Transbound Emerg Dis 2019 Feb 16. Epub 2019 Feb 16.

State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, China, Academy of Agricultural Sciences, Lanzhou, 730046, China.

Caprine parainfluenza virus type 3 (CPIV3) is a new member of the Respirovirus genus in the Paramyxivirudae family, mainly causing respiratory disease. Up to now, accumulating evidence has focused on CPIV3 infection in goats, with little understood about its epidemiology in sheep. To that end, we collected 1163 sheep sera samples from 9 provinces/autonomous regions in 2012 and 1863 samples from 6 provinces/autonomous regions during 2016-2017, with serological prevalence of 50. Read More

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http://doi.wiley.com/10.1111/tbed.13149
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http://dx.doi.org/10.1111/tbed.13149DOI Listing
February 2019
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Longitudinal active sampling for respiratory viral infections across age groups.

Influenza Other Respir Viruses 2019 Feb 15. Epub 2019 Feb 15.

Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York.

Background: Respiratory viral infections are a major cause of morbidity and mortality worldwide. However, their characterization is incomplete because prevalence estimates are based on syndromic surveillance data. Here, we address this shortcoming through the analysis of infection rates among individuals tested regularly for respiratory viral infections, irrespective of their symptoms. Read More

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http://doi.wiley.com/10.1111/irv.12629
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http://dx.doi.org/10.1111/irv.12629DOI Listing
February 2019
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Activation of upper respiratory tract mucosal innate immune responses in cats by liposomal toll-like receptor ligand complexes delivered topically.

J Vet Intern Med 2019 Feb 15. Epub 2019 Feb 15.

Center for Immune and Regenerative Medicine and the Center for Companion Animal Studies, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado.

Background: Nonspecific induction of local innate immune responses by mucosally administered immunotherapy is a new approach to protection from upper respiratory tract infections. Therefore, a new liposome-toll-like receptor complex (LTC) immune stimulant was developed and investigated for its ability to activate innate immune responses in cats, both in vitro and in vivo, as part of an initial evaluation of LTC for use as an immunotherapeutic agent in cats.

Objectives: We hypothesized that LTC could activate innate immune responses in cats after topical application to nasal and oropharyngeal mucosal surfaces. Read More

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http://dx.doi.org/10.1111/jvim.15426DOI Listing
February 2019

Development and validation of a novel clinical scoring system for short-term prediction of death in dogs with acute pancreatitis.

J Vet Intern Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Internal Medicine, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, France.

Background: Acute pancreatitis (AP) is associated with a high death rate in dogs, but accurate predictors of early death are still lacking.

Objectives: To develop a scoring system for prediction of short-term case fatality in dogs with AP.

Animals: One hundred sixty-nine dogs with AP including 138 dogs in the training cohort and 31 dogs in the validation cohort. Read More

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http://dx.doi.org/10.1111/jvim.15421DOI Listing
February 2019

Establishing an updated core domain set for studies in juvenile idiopathic arthritis: a report from the OMERACT 2018 JIA Workshop.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

E.M. Morgan MD, Associate Professor, Division of Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, J.E. Munro MBBS, Associate Professor, Head of Rheumatology at the Royal Children's Hospital, Melbourne, Australia and Group Leader Arthritis research, Murdoch Children's Research Institute Melbourne Australia, J. Horonjeff, PhD, Instructor, Office of Research, Division of Rheumatology, Columbia University Medical Center, New York, NY, B. Horgan, Consumer Advocate, Consumer and Community Health Research Network, Australia, B. Shea, PhD, Clinical Investigator, Ottawa Hospital Research Institute, Adjunct Professor, School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada, B.M. Feldman, MD, MSc, FRCPC, Professor Pediatrics, Medicine, Institute of Health Policy Management & Evaluation, University of Toronto, Head, Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, H. Clairman, M.Sc., Clinical Research Project Coordinator, Child Health Evaluative Sciences, Hospital for Sick Children, Toronto ON, C.O. Bingham III, MD; Professor of Medicine, Division of Rheumatology, Johns Hopkins University, Baltimore, MD; S. Thornhill, AA, Qualitative Research Consultant, Thornhill Associates, Hermosa Beach, CA, V. Strand MD, Adjunct Clinical Professor, Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA, A. Alongi, PhD Student, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Università degli studi di Genova, Genoa, Italy, S. Magni-Manzoni, M.D. Rheumatology Division, Ospedale Pediatrico Bambino Gesù, Roma, Italy, M. A.J. van Rossum, MD PhD, Pediatric Rheumatologist/Immunologist, Amsterdam Rheumatology and Immunology Center / Reade l Emma Children's Hospital Amsterdam Medical Center, Amsterdam, R. Vesely, MD, Head of the Rheumatology, Respiratory, Gastroenterology and Immunology Office Scientific and Regulatory Management Department European Medicines Agency, London, United Kingdom J. Vojinovic, MD PhD, Professor, University of Nis, Faculty of Medicine, Department of Pediatric Rheumatology, Serbia H.I. Brunner, Professor, Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, J.G. Harris, MD, Assistant Professor, Division of Rheumatology, Children's Mercy - Kansas City, Kansas City, MO, D.B. Horton, MD, MSCE, Assistant Professor, Division of Pediatric Rheumatology, Rutgers Robert Wood Johnson Medical School, Institute for Health, Health Care Policy and Aging Research, New Brunswick, NJ, D.J. Lovell, MD, Professor, Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, M. Mannion, MD, Assistant Professor of Rheumatology, University of Alabama at Birmingham, Birmingham, AL, H. Rahimi, MD, Assistant Professor, Division of Rheumatology, University of Rochester, Golisano Children's Hospital, Rochester, NY; A. Ravelli, MD, Professor of Pediatrics, Università degli Studi di Genova and IRCCS Istituto Giannina Gaslini, Genoa, Italy, S. Ringold, MD, Assistant Professor, Division of Rheumatology, Seattle Children's, Seattle, WA, Nicolino Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, M.S. Schrandt, J.D., Director, Patient Engagement, Arthritis Foundation, Atlanta, GA, S. Shenoi, MBBS, MS Associate Professor, Seattle Children's Hospital, Seattle, WA Natalie J. Shiff, MD, University of Florida, Shands Children's Hospital, Gainesville, FL, K. Toupin-April, PhD, Associate Scientist, Children's Hospital of Eastern Ontario Research Institute, Assistant Professor, Department of Pediatrics and School of Rehabilitation Sciences, University of Ottawa, Ottawa, Canada, N. Tzaribachev, MD, Pediatric Rheumatology Research Institute, Bad Bramstedt, Germany, P. Weiss, MD, MSCE, Associate Professor, Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, A. Consolaro, MD, PhD, Assistant Professor, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Università degli studi di Genova, Genoa, Italy, Address correspondence to: E.M. Morgan MD, Associate Professor of Pediatrics, Division of Rheumatology Cincinnati Children's Hospital Medical Center 3333 Burnet Ave, MLC 4010, Cincinnati, OH 45229; Email:

Objective: The current Juvenile Idiopathic Arthritis (JIA) Core Set used in randomized controlled trials (RCTs) and longitudinal observational studies (LOS) was developed without input of patients/parents. At OMERACT 2016, a special interest group voted to reconsider the core set incorporating broader stakeholder input. We describe subsequent work culminating in an OMERACT 2018 plenary and consensus voting. Read More

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http://dx.doi.org/10.3899/jrheum.181088DOI Listing
February 2019

Safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of the novel enzyme replacement therapy avalglucosidase alfa (neoGAA) in treatment-naïve and alglucosidase alfa-treated patients with late-onset Pompe disease: A phase 1, open-label, multicenter, multinational, ascending dose study.

Neuromuscul Disord 2018 Dec 17. Epub 2018 Dec 17.

Erasmus Medical Center, Pompe Center, Rotterdam, The Netherlands.

This multicenter/multinational, open-label, ascending-dose study (NCT01898364) evaluated safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of repeat-dose avalglucosidase alfa (neoGAA), a second-generation, recombinant acid α-glucosidase replacement therapy, in late-onset Pompe disease (LOPD). Patients ≥18 years, alglucosidase alfa naïve (Naïve) or previously receiving alglucosidase alfa for ≥9 months (Switch), with baseline FVC ≥50% predicted and independently ambulatory, received every-other-week avalglucosidase alfa 5, 10, or 20 mg/kg over 24 weeks. 9/10 Naïve and 12/14 Switch patients completed the study. Read More

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http://dx.doi.org/10.1016/j.nmd.2018.12.004DOI Listing
December 2018

Night-Time Transpiration - Favouring Growth?

Authors:
Wieland Fricke

Trends Plant Sci 2019 Feb 12. Epub 2019 Feb 12.

School of Biology and Environmental Sciences, University College Dublin, Belfield, Dublin 4, Ireland; https://people.ucd.ie/wieland.fricke. Electronic address:

Plants grow and transpire water during the day and night. Recent work highlights the idea that night-time transpirational water loss is a consequence of allowing respiratory CO to escape at sufficiently high rates through stomata. Respiration fuels night-time leaf expansion and requires carbohydrates produced during the day. Read More

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http://dx.doi.org/10.1016/j.tplants.2019.01.007DOI Listing
February 2019

Respiratory resistance among adults in a population-based cohort study in Northern Japan.

Respir Investig 2019 Feb 12. Epub 2019 Feb 12.

Department of Occupational Health, Tohoku University Graduate School of Medicine, Japan; Tohoku University Tohoku Medical Megabank Organization, Japan; Center for Environmental Conservation and Research Safety, Tohoku University, Japan. Electronic address:

Background: Forced oscillation technique (FOT) is a noninvasive method used to measure respiratory system resistance (Rrs) and reactance (Xrs) during quiet breathing, which has been extensively studied in clinical settings. The distribution of measured FOT values was previously assessed in a community-based cohort study. In this study, we aimed to confirm the distribution of measured FOT values in a different cohort in order to investigate the relationship between these values and patient clinical and biological data. Read More

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http://dx.doi.org/10.1016/j.resinv.2018.12.008DOI Listing
February 2019
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