Crit Care Med 2021 Jun 9. Epub 2021 Jun 9.
Center for Acute Respiratory Failure, Columbia University College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY. Department of Pharmacy, NewYork-Presbyterian Hospital, New York, NY. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Taibah University, Medina, Saudi Arabia. Department of Pharmacy, UC San Diego Health, San Diego, CA. Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY.
Objectives: In mechanically ventilated patients, deep sedation is often assumed to induce "respirolysis," that is, lyse spontaneous respiratory effort, whereas light sedation is often assumed to preserve spontaneous effort. This study was conducted to determine validity of these common assumptions, evaluating the association of respiratory drive with sedation depth and ventilator-free days in acute respiratory failure.
Design: Prospective cohort study. Read More