103,809 results match your criteria Respiratory Failure


Feasibility of an alternative, physiologic, individualized open-lung approach to high-frequency oscillatory ventilation in children.

Ann Intensive Care 2019 Jan 18;9(1). Epub 2019 Jan 18.

Department of Paediatrics, Division of Paediatric Critical Care Medicine, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Huispost CA 80, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands.

Background: High-frequency oscillatory ventilation (HFOV) is a common but unproven management strategy in paediatric critical care. Oscillator settings have been traditionally guided by patient age and/or weight rather than by lung mechanics, thereby potentially negating any beneficial effects. We have adopted an open-lung HFOV strategy based on a corner frequency approach using an initial incremental-decremental mean airway pressure titration manoeuvre, a high frequency (8-15 Hz), and high power to initially target a proximal pressure amplitude (∆P) of 70-90 cm HO, irrespective of age or weight. Read More

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https://annalsofintensivecare.springeropen.com/articles/10.1
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http://dx.doi.org/10.1186/s13613-019-0492-0DOI Listing
January 2019
1 Read

Clinical phenotype, in silico and biomedical analyses, and intervention for an East Asian population-specific c.370G>A (p.G124S) COQ4 mutation in a Chinese family with CoQ10 deficiency-associated Leigh syndrome.

J Hum Genet 2019 Jan 18. Epub 2019 Jan 18.

United Diagnostic and Research Center for Clinical Genetics, School of Public Health of Xiamen University & Xiamen Maternal and Child Health Hospital, Xiamen, Fujian, 361003, China.

COQ4 mutations have recently been shown to cause a broad spectrum of mitochondrial disorders in association with CoQ10 deficiency. Herein, we report the clinical phenotype, in silico and biochemical analyses, and intervention for a novel c.370 G > A (p. Read More

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http://www.nature.com/articles/s10038-019-0563-y
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http://dx.doi.org/10.1038/s10038-019-0563-yDOI Listing
January 2019
1 Read

Motile cilia of the male reproductive system require miR-34/miR-449 for development and function to generate luminal turbulence.

Proc Natl Acad Sci U S A 2019 Jan 18. Epub 2019 Jan 18.

Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557;

Cilia are cell-surface, microtubule-based organelles that project into extracellular space. Motile cilia are conserved throughout eukaryotes, and their beat induces the flow of fluid, relative to cell surfaces. In mammals, the coordinated beat of motile cilia provides highly specialized functions associated with the movement of luminal contents, as seen with metachronal waves transporting mucus in the respiratory tract. Read More

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http://dx.doi.org/10.1073/pnas.1817018116DOI Listing
January 2019

Protocol for a feasibility randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients.

BMJ Open 2019 Jan 17;9(1):e021674. Epub 2019 Jan 17.

Integrative Physiology and Critical Illness Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

Introduction: Oxygen is the most commonly administered drug to mechanically ventilated critically ill adults, yet little is known about the optimum oxygen saturation (SpO) target for these patients; the current standard of care is an SpO of 96% or above. Small pilot studies have demonstrated that permissive hypoxaemia (aiming for a lower SpO than normal by using a lower fractional inspired oxygen concentration (FIO)) can be achieved in the critically ill and appears to be safe. This approach has not been evaluated in a National Health Service setting. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-021674DOI Listing
January 2019

Predictors of Hospital Cost After Transcatheter Aortic Valve Implantation in the United States: From the Nationwide Inpatient Sample Database.

Am J Cardiol 2019 Jan 8. Epub 2019 Jan 8.

Wayne State University/Detroit Medical Center, Detroit, Michigan. Electronic address:

We aimed to identify risk factors of high hospitalization cost after transcatheter aortic valve implantation (TAVI). TAVI expenditure is generally higher compared with surgical aortic valve replacement. We queried the Nationwide Inpatient Sample database from January 2011 to September 2015 to identify those who underwent endovascular TAVI. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.12.044DOI Listing
January 2019

Evaluating the efficacy of Seattle-PAP for the respiratory support of premature neonates: study protocol for a randomized controlled trial.

Trials 2019 Jan 18;20(1):63. Epub 2019 Jan 18.

Seattle Children's Research Institute, Seattle Children's Hospital, Seattle, WA, USA.

Background: At birth, the majority of neonates born at <30 weeks of gestation require respiratory support to facilitate transition and ensure adequate gas exchange. Although the optimal approach to the initial respiratory management is uncertain, the American Academy of Pediatrics endorses noninvasive respiratory support with nasal continuous positive airway pressure (nCPAP) for premature neonates with respiratory insufficiency. Despite evidence for its use, nCPAP failure, requiring intubation and mechanical ventilation, is common. Read More

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http://dx.doi.org/10.1186/s13063-018-3166-6DOI Listing
January 2019

Vascular endothelial cadherin shedding is more severe in sepsis patients with severe acute kidney injury.

Crit Care 2019 Jan 18;23(1):18. Epub 2019 Jan 18.

Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, T1218 MCN, 1161 21st, Avenue S, Nashville, TN, 37232, USA.

Background: Vascular endothelial cadherin (VE-cadherin) is a membrane protein that is the major component of adherens junctions between endothelial cells. It is crucial for regulating vascular integrity, endothelial permeability, and angiogenesis. During inflammatory processes, VE-cadherin is shed into circulation (sVE-cadherin). Read More

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https://ccforum.biomedcentral.com/articles/10.1186/s13054-01
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http://dx.doi.org/10.1186/s13054-019-2315-yDOI Listing
January 2019
1 Read

Hypersensitivity Reactions in Serious Adverse Events Reported for Paracetamol in the EudraVigilance Database, 2007⁻2018.

Pharmacy (Basel) 2019 Jan 17;7(1). Epub 2019 Jan 17.

Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, 31-531 Krakow, Poland.

Paracetamol is a popular and easily available drug which is used world-wide as analgesic, antipyretic agent. Hypersensitivity reactions to this drug involve a wide range of symptoms of various importance for patient management. The EudraVigilance (EV) database serves as a system for monitoring adverse events (AE) due to drug intake. Read More

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http://dx.doi.org/10.3390/pharmacy7010012DOI Listing
January 2019
1 Read

Lung Volume Optimization Maneuver Responses in Pediatric High Frequency Oscillatory Ventilation.

Am J Respir Crit Care Med 2019 Jan 18. Epub 2019 Jan 18.

Beatrix Children's Hospital, Department of Paediatrics, division of Paediatric Critical Care Medicine, Groningen, Netherlands.

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http://dx.doi.org/10.1164/rccm.201809-1769LEDOI Listing
January 2019

Hyponatraemia in patients with community acquired pneumonia; prevalence and etiology, and natural history of siad.

Clin Endocrinol (Oxf) 2019 Jan 18. Epub 2019 Jan 18.

Academic Departments of Endocrinology, Chemical Pathology, Beaumont Hospital, RCSI Medical School.

Objective: Hyponatraemia is common in community acquired pneumonia (CAP) and is associated with increased mortality. The mechanism of hyponatraemia in CAP is not completely understood and treatment is therefore ill-defined. We aimed to define the causation of hyponatraemia in CAP. Read More

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http://dx.doi.org/10.1111/cen.13937DOI Listing
January 2019

Safety-oriented design of in-house software for new techniques: a case study using a model-based 4DCT protocol.

Med Phys 2019 Jan 17. Epub 2019 Jan 17.

Department of Radiation Oncology, University of California, Los Angeles. 200 Medical Plaza Suite B265, Los Angeles, California, 90095.

Purpose: In-house software is commonly employed to implement new imaging and therapy techniques before commercial solutions are available. Risk analysis methods, as detailed in the TG-100 report of the AAPM, provide a framework for quality management of processes but offer little guidance on software design. In this work, we examine a novel model-based 4DCT protocol using the TG-100 approach and describe two additional methods for promoting safety of the associated in-house software. Read More

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http://dx.doi.org/10.1002/mp.13386DOI Listing
January 2019

Amyotrophic lateral sclerosis and anesthesia: a case series and review of the literature.

J Anesth 2019 Jan 17. Epub 2019 Jan 17.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

Purpose: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that leads to death due to respiratory failure. This report describes the perioperative characteristics of ALS patients who underwent procedures with anesthesia at our institution.

Methods: We reviewed perioperative records of ALS patients who underwent procedures with anesthesia from January 1, 2014, through December 31, 2015. Read More

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http://dx.doi.org/10.1007/s00540-019-02611-xDOI Listing
January 2019

Statins improve survival in patients previously treated with nivolumab for advanced non-small cell lung cancer: An observational study.

Mol Clin Oncol 2019 Jan 13;10(1):137-143. Epub 2018 Nov 13.

Department of Thoracic Oncology and Respiratory Medicine, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo 113-867, Japan.

There are a number of suggested predictive factors of nivolumab for non-small cell lung cancer (NSCLC), however, there is not enough evidence to determine a single factor that can predict the efficacy of nivolumab. As the progress of biomarkers for cancer treatment is improving, it has been speculated that certain clinical factors serve an important role when predicting the outcome of chemotherapy. A total of 67 patients treated with nivolumab for NSCLC from 2016-2017 were prospectively investigated. Read More

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http://www.spandidos-publications.com/10.3892/mco.2018.1765
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http://dx.doi.org/10.3892/mco.2018.1765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313973PMC
January 2019
1 Read

High-flow nasal cannula therapy for children with bronchiolitis: a systematic review and meta-analysis.

Arch Dis Child 2019 Jan 17. Epub 2019 Jan 17.

Respiratory Department, Children's Hospital of Chongqing Medical University, Chongqing, China.

Objectives: To review the effects and safety of high-flow nasal cannula (HFNC) for bronchiolitis.

Methods: Six electronic databases including PubMed, EMBASE, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, CQ VIP Database and Wanfang Data were searched from their inception to 1 June 2018. Randomised controlled trials (RCTs) which investigated the effects of HFNC versus other forms of oxygen therapies for bronchiolitis were included. Read More

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http://adc.bmj.com/lookup/doi/10.1136/archdischild-2018-3158
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http://dx.doi.org/10.1136/archdischild-2018-315846DOI Listing
January 2019
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Intraoperative Use of Nondepolarizing Neuromuscular Blocking Agents During Cardiac Surgery and Postoperative Pulmonary Complications: A Prospective Randomized Trial.

J Cardiothorac Vasc Anesth 2018 Nov 28. Epub 2018 Nov 28.

Department of Anesthesia and Critical Care, University of Chicago Medicine, Chicago, IL.

Objective: Nondepolarizing neuromuscular blocking agents (NMBAs) are associated with perioperative complications in noncardiac surgery; however, little is known about their effect on cardiac surgery. This study assessed the effect of neuromuscular blockade (NMB) on the incidence of postoperative pulmonary complications (PPCs) after cardiac surgery and operating conditions.

Design: Prospective, randomized clinical trial with blinded outcomes assessment. Read More

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http://dx.doi.org/10.1053/j.jvca.2018.11.043DOI Listing
November 2018
1 Read

The hand of respiratory failure.

Eur J Intern Med 2019 Jan 15. Epub 2019 Jan 15.

Division of Pulmonary Medicine (NS), St. Agnes Hosipital, Baltimore, Maryland 21229, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejim.2019.01.003DOI Listing
January 2019

Lung Transplantation as Successful Treatment of End-stage Idiopathic Pleuroparenchymal Fibroelastosis: A Case Report.

Transplant Proc 2018 Jun 28. Epub 2018 Jun 28.

Thoracic Surgery and Lung Transplant Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

Pleuroparenchymal fibroelastosis (PPFE) is a rare condition, characterized by predominantly upper-lobe pleural and subjacent parenchymal fibrosis, the latter being intra-alveolar with accompanying elastosis of the alveolar walls that leads a clinical progression to respiratory failure. This condition may not be as rare as it seems to be, because nowadays the increasing awareness among specialists is raising the number of new diagnoses. Limited data are available about the prognosis, both for secondary and idiopathic forms. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.071DOI Listing

A decade of interfacility extracorporeal membrane oxygenation transport.

J Thorac Cardiovasc Surg 2018 Nov 29. Epub 2018 Nov 29.

Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tenn. Electronic address:

Objective: Extracorporeal membrane oxygenation (ECMO) is used to provide support for patients with cardiopulmonary failure. Best available medical management often fails in these patients and referring hospitals have no further recourse for escalating care apart from transfer to a tertiary facility. In severely unstable patients, the only option might be to use ECMO to facilitate safe transport. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2018.09.139DOI Listing
November 2018

Wishes to die at the end of life and subjective experience of four different typical dying trajectories. A qualitative interview study.

PLoS One 2019 17;14(1):e0210784. Epub 2019 Jan 17.

Hospiz im Park, Hospital for Palliative Care, Arlesheim, Switzerland.

Research Aims: The motivations that lead to wishes to die (WTD) in palliative care patients with cancer are relatively well studied. But little is known about WTD in other pathologies and the relation between subjective understandings of dying trajectories and a WTD. We investigated the WTD of palliative patients in four different dying trajectories: neurological diseases, organ failure, frailty due to age, and cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210784PLOS
January 2019

Delayed malposition of a double-lumen hemodialysis catheter that caused hemorrhage and hypovolemic shock: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14192

Department of Emergency Medicine, Kaohsiung Medical University Hospital.

Rationale: Double-lumen hemodialysis catheters are commonly used as temporary hemodialysis routes. Complications include infection, thrombosis, cardiac arrhythmia, entrapped guide wire, and malposition. We report a rare complication of delayed hemodialysis catheter malposition that caused retroperitoneal hemorrhage and hypovolemic shock during hemodialysis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014192DOI Listing
January 2019

Periprosthetic metastasis following total hip arthroplasty in a patient with lung carcinoma: A case report and review of literature.

Medicine (Baltimore) 2019 Jan;98(3):e14071

Department of Orthopedics, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, The First Affiliated Hospital of Nanchang University, China.

Rationale: Periprosthetic osteolysis secondary to septic loosening and aseptic loosening is a well-described phenomenon associated with artificial hip arthroplasty. Periprosthetic bone loss as a result of metastatic infiltration is an uncommon cause of early, progressive loosening of joint replacement prosthesis and is rarely described in the literature.

Patient Concerns: The present study describes a 70-year-old male patient who was diagnosed with pulmonary squamous cell carcinoma 5 years after total hip arthroplasty (THA) and developed a metastasis from squamous cell carcinoma in the periprosthetic neosynovial tissue 1 year after formal chemotherapy. Read More

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http://dx.doi.org/10.1097/MD.0000000000014071DOI Listing
January 2019

The evaluation of the postoperative course in patients operated due to abdominal aortic aneurysm as urgent or elective procedure.

Pol Przegl Chir 2018 Sep;90(6):1-5

Wroclaw Medical University Faculty of Health Science Division of Surgical Specialties.

Introduction: The patients with the aortic abdominal aneurysm of 55mm in diameter are qualified for surgery. There is open repair (OR) by means of the vascular prosthesis implantation or the less invasive endovascular method by means of the stent graft implantation through femoral arteries incision (EndovascularAorticRepair - EVAR). The aim of the study was the evaluation of the postoperative course in patients operated due to the aortic abdominal aneurysm and the evaluation of the impact of the surgical method on the short-time results. Read More

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https://ppch.pl/gicid/01.3001.0012.4713
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http://dx.doi.org/10.5604/01.3001.0012.4713DOI Listing
September 2018
2 Reads

Hypoplastic right ventricle in a dog.

Authors:
Alaina Macdonald

Can Vet J 2019 Jan;60(1):89-91

Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.

A 7-week-old male crossbred puppy was presented in acute respiratory distress. A diagnosis of left- and right-sided heart failure was confirmed on postmortem examination. The heart had a severely hypoplastic right ventricle. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294080PMC
January 2019

The National Early Warning Score 2 (NEWS2) in patients with hypercapnic respiratory failure.

Authors:
Bryan Williams

Clin Med (Lond) 2019 Jan;19(1):94-95

University College London, London, UK.

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http://dx.doi.org/10.7861/clinmedicine.19-1-94DOI Listing
January 2019

Morbidity and mortality in a population of patients affected by heart failure and chronic obstructive pulmonary disease: an observational study.

BMC Cardiovasc Disord 2019 Jan 16;19(1):20. Epub 2019 Jan 16.

Cardio-Thoracic-Vascular Department, Policlinico S. Orsola-Malpighi, Università di Bologna, Via Albertoni 15, 40138, Bologna, Italy.

Background: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) often coexist. Moreover, elderly patients suffering from HF have a higher incidence of COPD, which further complicates their clinical condition. Indacaterol/glycopirronium has shown benefits in the treatment of COPD, with few cardiologic adverse effects. Read More

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https://bmccardiovascdisord.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s12872-018-0986-yDOI Listing
January 2019
2 Reads

The geriatric nutritional risk index independently predicts adverse outcomes in patients with pyogenic liver abscess.

BMC Geriatr 2019 Jan 16;19(1):14. Epub 2019 Jan 16.

Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109 West Xueyuan Road, Wenzhou, China.

Background: Geriatric nutritional risk index (GNRI) is a simple and useful nutritional marker for predictor of adverse outcomes in patients undergoing a variety of conditions. This study explored the relationship between GNRI and adverse outcomes of Pyogenic Liver Abscess (PLA) patients and assessed GNRI predictive value.

Methods: This was one retrospective study involving 240 PLA patients. Read More

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https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877
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http://dx.doi.org/10.1186/s12877-019-1030-5DOI Listing
January 2019
2 Reads

Molecular Pathways and Respiratory Involvement in Lysosomal Storage Diseases.

Int J Mol Sci 2019 Jan 15;20(2). Epub 2019 Jan 15.

Rare Metabolic Diseases Unit, Pediatric Department, Fondazione MBBM, Università degli Studi di Milano Bicocca, San Gerardo Hospital, ASST di Monza, 20900 Monza, Italy.

Lysosomal storage diseases (LSD) include a wide range of different disorders with variable degrees of respiratory system involvement. The purpose of this narrative review is to treat the different types of respiratory manifestations in LSD, with particular attention being paid to the main molecular pathways known so far to be involved in the pathogenesis of the disease. A literature search was conducted using the Medline/PubMed and EMBASE databases to identify studies, from 1968 through to November 2018, that investigated the respiratory manifestations and molecular pathways affected in LSD. Read More

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http://dx.doi.org/10.3390/ijms20020327DOI Listing
January 2019

Apnea hypopnea index during rapid eye movement sleep with diabetic retinopathy in patients with type 2 diabetes.

J Clin Endocrinol Metab 2019 Jan 11. Epub 2019 Jan 11.

Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.

Context: Recent studies based on home sleep apnea testing (HSAT) reported the potential association of sleep disordered breathing (SDB), such as obstructive sleep apnea (OSA), with diabetic retinopathy (DR). A few studies showed that the apnea hypopnea index during rapid eye movement sleep (REM-AHI) is associated with glycated hemoglobin and hypertension, two known risk factors for DR. However, there are no studies that have evaluated the association of REM-AHI with DR because previous studies were based on HSAT. Read More

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https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
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http://dx.doi.org/10.1210/jc.2018-00946DOI Listing
January 2019
1 Read

Pulmonary Cavitary Disease Secondary to Mycobacterium xenopi Complicated by Respiratory Failure.

Cureus 2018 Oct 29;10(10):e3512. Epub 2018 Oct 29.

Internal Medicine, Staten Island University Hospital, Northwell Health, Staten Island, USA.

Non-tuberculous mycobacteria (NTM) are a significant cause of pulmonary infection worldwide and can be clinically challenging. Mycobacterium xenopi (M. xenopi) has low pathogenicity and usually requires either host immune impairment, as in the case of a human immunodeficiency virus infection, or a structural lung disease to cause a clinical disease. Read More

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https://www.cureus.com/articles/14545-pulmonary-cavitary-dis
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http://dx.doi.org/10.7759/cureus.3512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318116PMC
October 2018
1 Read

Absence of early metabolic response assessed by 18F-FDG PET/CT after initiation of antifibrotic drugs in IPF patients.

Respir Res 2019 Jan 15;20(1):10. Epub 2019 Jan 15.

Department of Nuclear Medicine, Erasme University Hospital, Université libre de Bruxelles (ULB), route de Lennik 808, 1070, Brussels, Belgium.

Background: Idiopathic pulmonary fibrosis (IPF) is characterized by a progressive and irreversible respiratory failure. Non-invasive markers of disease activity are essential for prognosis and evaluation of early response to anti-fibrotic treatments.

Objectives: The aims of this study were to determine whether fluorodeoxyglucose ([18F]-FDG) lung uptake is reduced after initiation of pirfenidone or nintedanib and to assess its possible use as a prognostic factor. Read More

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http://dx.doi.org/10.1186/s12931-019-0974-5DOI Listing
January 2019

Management of Acute Respiratory Failure Due to Community-Acquired Pneumonia: A Systematic Review.

Med Sci (Basel) 2019 Jan 14;7(1). Epub 2019 Jan 14.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Internal Medicine Department, Respiratory unit and Adult Cystic Fibrosis Center, 20122 Milan, Italy.

Community-acquired pneumonia (CAP) is a leading cause of mortality worldwide. CAP mortality is driven by the development of sepsis and acute respiratory failure (ARF). We performed a systematic review of the available English literature published in the period 1 January 1997 to 31 August 2017 and focused on ARF in CAP. Read More

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http://www.mdpi.com/2076-3271/7/1/10
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http://dx.doi.org/10.3390/medsci7010010DOI Listing
January 2019
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Obesity cardiomyopathy: the role of obstructive sleep apnea and obesity hypoventilation syndrome.

Ir J Med Sci 2019 Jan 15. Epub 2019 Jan 15.

Respiratory Division, University Hospital Limerick, Limerick, Ireland.

The negative long-term health consequences of obesity are well known to both the medical profession and general public. Despite this, the number of obese and overweight individuals worldwide continues to steadily rise. Although obesity has long been associated with an increased risk for cardiovascular disease and mortality, the classification of a cardiomyopathy of obesity is a more recent development. Read More

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http://link.springer.com/10.1007/s11845-018-01959-5
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http://dx.doi.org/10.1007/s11845-018-01959-5DOI Listing
January 2019
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Pediatric Early Warning Scores and Declining Ward Patients on High Flow Therapy.

Pediatr Int 2019 Jan 15. Epub 2019 Jan 15.

Division of Pediatric Critical Care, Department of Pediatrics, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Background: Delivery of noninvasive ventilation commonly occurs in the pediatric intensive care unit (PICU). With the advent of high flow nasal cannula (HFNC), patients with respiratory distress may be rescued on the ward without a PICU admission. We evaluated our ward HFNC algorithm to determine its safety profile and independent predictors for non-responders, defined as requiring a subsequent PICU admission. Read More

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http://dx.doi.org/10.1111/ped.13787DOI Listing
January 2019

Severe intestinal ischemia during chemotherapy for small cell lung cancer.

Lung Cancer Manag 2017 Dec 1;6(3):87-91. Epub 2017 Dec 1.

Department of Pulmonology, Respiratory Oncology Unit, University Hospitals Leuven, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium.

Thromboembolic events (TEEs) are frequent in cancer patients, especially venous thrombosis. Arterial thrombosis is less frequent. Chemotherapy increases the risk of these TEEs. Read More

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https://www.futuremedicine.com/doi/10.2217/lmt-2017-0016
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http://dx.doi.org/10.2217/lmt-2017-0016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310311PMC
December 2017
1 Read

Clinical impact of body composition phenotypes in patients with COPD: a retrospective analysis.

Eur J Clin Nutr 2019 Jan 14. Epub 2019 Jan 14.

Department of Physiotherapy, Laboratory of Research in Respiratory Physiotherapy (LFIP), State University of Londrina, Londrina, Brazil.

Background/objectives: Abnormal body composition is an independent determinant of COPD outcomes. To date, it is already known that patient stratification into body composition phenotypes are associated with important outcomes, such as exercise capacity and inflammation, but there are no data comparing physical activity and muscle strength among these phenotypes. Thus, the aim of this study was to compare clinical characteristics and physical function in patients with COPD stratified into body composition phenotypes. Read More

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http://dx.doi.org/10.1038/s41430-019-0390-4DOI Listing
January 2019
1 Read

Germline deletion reveals a non-essential role of the atypical MAPK6/ERK3.

Mol Cell Biol 2019 Jan 14. Epub 2019 Jan 14.

Institute of Cell Biochemistry, Hannover Medical School, Hannover, Germany

MAPK6/ERK3 is an atypical member of the MAPKs. An essential role has been suggested by the perinatal lethal phenotype of ERK3 knockout mice carrying a lacZ insertion in exon 2 due to pulmonary disfunction and by defects in function, activation and positive selection of T cells. To study the role of ERK3 , we generated mice carrying a conditional allele with exon3 flanked by LoxP sites. Read More

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http://dx.doi.org/10.1128/MCB.00516-18DOI Listing
January 2019

The role of high-flow nasal cannula therapy in patients with respiratory failure.

CMAJ 2019 Jan;191(2):E53

Intensivist, Dongyang People's Hospital, Jinhua, Zhejiang, China.

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http://dx.doi.org/10.1503/cmaj.71024DOI Listing
January 2019

ECMO for ARDS: from salvage to standard of care?

Lancet Respir Med 2019 Jan 11. Epub 2019 Jan 11.

Columbia University College of Physicians and Surgeons and New York-Presbyterian Hospital, 622 West 168th Street, New York 10032, NY, USA; Center for Acute Respiratory Failure, Columbia University Medical Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30506-XDOI Listing
January 2019

Long-term follow-up and characteristic pathological findings in severe nemaline myopathy due to LMOD3 mutations.

Neuromuscul Disord 2018 Dec 20. Epub 2018 Dec 20.

Department of Pediatrics, Sahlgrenska Academy, Institute of Clinical Sciences, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.

We describe the long-term follow-up of a patient with severe nemaline myopathy due to a novel homozygous mutation in the Leiomodin 3 (LMOD3) gene and describe the histopathological characteristics of the disease. The patient presented at birth with hydrops fetalis, multiple joint contractures, severe generalized muscle weakness, no movement, and respiratory insufficiency. At eight years of age, she had bilateral ophthalmoplegia, visual impairment, multiple contractures, and scoliosis, and is dependent on a home mechanical ventilator and gastrostomy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09608966183058
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http://dx.doi.org/10.1016/j.nmd.2018.12.009DOI Listing
December 2018
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Impact of afatinib dose modification on safety and effectiveness in patients with EGFR mutation-positive advanced NSCLC: Results from a global real-world study (RealGiDo).

Lung Cancer 2019 Jan 2;127:103-111. Epub 2018 Nov 2.

Department of Medical Oncology, Catalan Institute of Oncology Badalona, Hospital Germans Trias i Pujol, Badalona, Spain. Electronic address:

Objectives: In the LUX-Lung clinical trials of afatinib in EGFR mutation-positive NSCLC, tolerability-guided dose adjustment reduced the incidence and severity of adverse events while maintaining efficacy. The RealGiDo study evaluated the impact of afatinib dose adjustment in a real-world setting.

Materials And Methods: This non-interventional, observational study used medical records of EGFR mutation-positive NSCLC patients treated with first-line afatinib. Read More

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http://dx.doi.org/10.1016/j.lungcan.2018.10.028DOI Listing
January 2019

Pediatric in-hospital emergencies: real life experiences, previous training and the need for training among physicians and nurses.

BMC Res Notes 2019 Jan 14;12(1):19. Epub 2019 Jan 14.

Department for Assessment and Evaluation, Institute for Medical Education, Mittelstrasse 43, 3012, Bern, Switzerland.

Objective: Pediatric emergencies challenge professional teams by demanding substantial cognitive effort, skills and effective teamwork. Educational designs for team trainings must be aligned to the needs of participants in order to increase effectiveness. To assess these needs, a survey among physicians and nurses of a tertiary pediatric center in Germany was conducted, focusing on previous experience, previous training in emergency care, and individual training needs. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-019-4051-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332611PMC
January 2019
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Respiratory muscle testing in amyotrophic lateral sclerosis: a practical approach.

Minerva Med 2018 Dec;109(6 Suppl 1):11-19

Department of Neurorehabilitation Sciences, Casa di Cura Privata del Policlinico, Milan, Italy.

In amyotrophic lateral sclerosis (ALS), respiratory muscle weakness leads to respiratory failure and death. Non-invasive positive pressure ventilation (NIPPV) appears to reduce lung function decline, thus improving survival and quality-of-life of patients affected by the disease. Unfortunately, clinical features and timing to start NIPPV are not well defined. Read More

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https://www.minervamedica.it/index2.php?show=R10Y2018S01A001
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http://dx.doi.org/10.23736/S0026-4806.18.05920-7DOI Listing
December 2018
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Non-invasive ventilation in acute respiratory failure of patients with obesity hypoventilation syndrome.

Minerva Med 2018 Dec;109(6 Suppl 1):1-5

Unit of Respiratory Diseases and Allergies, Department of Internal Medicine (DiMI), San Martino University Hospital, Genoa, Italy.

Introduction: Non-invasive ventilation (NIV) has been used successfully for the management of acute respiratory failure (ARF) more often in the last two decades compared to prior decades. There are particular groups of patients that are more likely to benefit from NIV. One of these groups is patients with obesity hypoventilation syndrome (OHS). Read More

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http://dx.doi.org/10.23736/S0026-4806.18.05921-9DOI Listing
December 2018

IMPACT probability of poor outcome and plasma cytokine concentrations are associated with multiple organ dysfunction syndrome following traumatic brain injury.

J Neurosurg 2019 Jan 11:1-7. Epub 2019 Jan 11.

Departments of1Neurosurgery and.

OBJECTIVETraumatic brain injury (TBI) is a major cause of morbidity and mortality. Multiple organ dysfunction syndrome (MODS) occurs frequently after TBI and independently worsens outcome. The present study aimed to identify potential admission characteristics associated with post-TBI MODS. Read More

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http://dx.doi.org/10.3171/2018.8.JNS18676DOI Listing
January 2019
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Effects of Bronchoscopic Lung Volume Reduction Coil Treatment on Arterial Blood Gases.

Authors:
Askin Gülsen

J Bronchology Interv Pulmonol 2019 Jan 11. Epub 2019 Jan 11.

Division of Clinical and Molecular Allergology, Research Center Borstel, Airway Research, Center North (ARCN), Borstel, Germany.

Background: Bronchoscopic lung volume reduction (BLVR) coil treatment is an increasingly used treatment modality for selected severe emphysema patients in recent years. Emphysema causes dynamic hyperinflation, loss of elastic recoil, air trapping, and decreased exercise capacity in advanced stages. This process progresses over time, leading to hypoxic and hypercapnic respiratory failure. Read More

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http://dx.doi.org/10.1097/LBR.0000000000000529DOI Listing
January 2019

Adjunct corticosteroid treatment in patients with pneumonia: A precision medicine approach.

Bosn J Basic Med Sci 2019 Jan 12. Epub 2019 Jan 12.

Intensive Care Unit, Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.

Pneumonia is the leading infectious cause of death worldwide. While inflammation is critically important in host response to microbial invasion, exaggerated inflammation can damage the lungs, contributing to respiratory failure and mortality. Corticosteroids are effective in reducing inflammation and can also cause immune suppression. Read More

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http://dx.doi.org/10.17305/bjbms.2019.3977DOI Listing
January 2019
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Noncystic fibrosis bronchiectasis management: opportunities and challenges.

Curr Opin Pulm Med 2019 Jan 10. Epub 2019 Jan 10.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

Purpose Of Review: Noncystic fibrosis bronchiectasis is a challenging disease which carries a heavy healthcare burden and significant mortality and morbidity. This review highlights the challenges in the diagnosis of bronchiectasis and discusses the management strategies and research opportunities in this field.

Recent Findings: The challenges in the management of bronchiectasis appear to be multifactorial, arising from both etiological heterogeneity and disease-specific management. Read More

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http://dx.doi.org/10.1097/MCP.0000000000000562DOI Listing
January 2019

Assessment of adherence and asthma medication ratio (AMR) for a once-daily and twice-daily inhaled corticosteroid/long acting beta agonist (ICS/LABA) for asthma.

J Allergy Clin Immunol Pract 2019 Jan 9. Epub 2019 Jan 9.

Health Economics and Outcomes Research, Optum, Inc., Eden Prairie, MN.

Background: While efficacy and safety of fluticasone furoate/vilanterol (FF/VI) and budesonide/formoterol (BUD/F) have been demonstrated in clinical studies, real-world comparisons of utilization has not been performed.

Objective: Compare similar asthma patients initiating FF/VI or BUD/F on measures of adherence, persistence, and the asthma medication ratio (AMR).

Methods: This was a retrospective cohort study of commercial and Medicare Advantage with Part D enrollees initiating FF/VI or BUD/F for asthma. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.12.021DOI Listing
January 2019
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The clinical management of neuromuscular disorders in intensive care.

Neuromuscul Disord 2018 Dec 18. Epub 2018 Dec 18.

Neurology Division of Critical Care Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Life-threatening neuromuscular disorders affect a small, but growing group of patients in the intensive care unit who present special management problems, as well as great therapeutic opportunities. In inflammatory conditions, a cure is often possible, and for chronic, genetic or degenerative conditions, achieving the previous level of function is the target. Neuromuscular experts and intensivists need to cooperate closely to achieve the best possible outcomes. Read More

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http://dx.doi.org/10.1016/j.nmd.2018.12.005DOI Listing
December 2018
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Prevalence and profile of "seasonal frequent flyers" with chronic heart disease: Analysis of 1598 patients and 4588 patient-years follow-up.

Int J Cardiol 2019 Jan 2. Epub 2019 Jan 2.

University of Cape Town, Cape Town, South Africa. Electronic address:

Background: Peaks and troughs in cardiovascular events correlated with seasonal change is well established from an epidemiological perspective but not a clinical one.

Methods: Retrospective analysis of the recruitment, baseline characteristics and outcomes during minimum 12-month exposure to all four seasons in 1598 disease-management trial patients hospitalised with chronic heart disease. Seasonality was prospectively defined as ≥4 hospitalisations (all-cause) AND >45% of related bed-days occurring in any one season during median 988 (IQR 653, 1394) days follow-up. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01675273183560
Publisher Site
http://dx.doi.org/10.1016/j.ijcard.2018.12.060DOI Listing
January 2019
2 Reads