2,368 results match your criteria Respiratory Alkalosis


Chronic Salicylate Toxicity Simulation.

MedEdPORTAL 2018 Aug 17;14:10741. Epub 2018 Aug 17.

Assistant Professor, Department of Emergency Medicine, Wake Forest Baptist Medical Center.

Introduction: Chronic salicylate toxicity is an uncommon, potentially life-threatening poisoning that requires high clinical suspicion in order to make the diagnosis. We created a simulation case that challenges learners to analyze case information, construct a differential diagnosis of an elevated anion gap metabolic acidosis with respiratory alkalosis, and initiate treatment for this toxicity.

Methods: The simulation case was designed for emergency medicine residents and pediatric emergency medicine fellows. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342349PMC
August 2018
1 Read

The effect of inspiratory muscle fatigue on acid-base status and performance during race-paced middle-distance swimming.

J Sports Sci 2019 Feb 6:1-7. Epub 2019 Feb 6.

b Faculty of Sport , University of Ljubljana , Ljubljana , Slovenia.

The aim of this study was to investigate the effect of pre-induced inspiratory muscle fatigue (IMF) on race-paced swimming and acid-base status. Twenty-one collegiate swimmers performed two discontinuous 400-m race-paced swims on separate days, with (IMF trial) and without (control trial) pre-induced IMF. Swimming characteristics, inspiratory and expiratory mouth pressures, and blood parameters were recorded. Read More

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http://dx.doi.org/10.1080/02640414.2019.1574250DOI Listing
February 2019
2 Reads

Levofloxacin-associated Encephalopathy with Severe Hyperventilation.

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Internal Medicine, Tokyo Women's Medical University Medical Center East, Japan.

A 64-year-old woman with no previous mental illness took a single 500 mg tablet of levofloxacin for cystitis. Two hours later, she developed psychosis with involuntary movement and severe hyperventilation with respiratory alkalosis. Cranial magnetic resonance imaging findings were unremarkable, and an electroencephalogram revealed no epileptiform discharge. Read More

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http://dx.doi.org/10.2169/internalmedicine.1619-18DOI Listing
February 2019
1 Read

Extreme Metabolic Alkalosis and Acute Kidney Injury in a 38-Year-Old Male Patient.

Indian J Crit Care Med 2018 Dec;22(12):883-885

Department of Internal Medicine, Stuttgart Hospital, Stuttgart, Germany.

Repeated vomiting may lead to profound loss of fluid and electrolytes. We describe a case with life-threatening acid-base disturbances due to vomiting. A 38-year-old man presented to an emergency department with weakness and decreased urine output after having vomited up to 20 times per day over a period of 7 days. Read More

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http://dx.doi.org/10.4103/ijccm.IJCCM_180_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311974PMC
December 2018
2 Reads

The exhausting work of acclimating to chronically elevated CO.

J Physiol 2019 Mar 30;597(6):1421-1423. Epub 2019 Jan 30.

Department of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1113/JP277491DOI Listing
March 2019
4 Reads

Renal aspects of metabolic acid-base disorders in neonates.

Pediatr Nephrol 2018 Nov 19. Epub 2018 Nov 19.

Lausanne University Medical School, CHUV-1011, Lausanne, Switzerland.

Acid-base homeostasis is one of the most tightly regulated systems in the body. Maintaining the acid-base balance is particularly challenging for preterm infants and growing neonates. The kidney, which represents the crucial ultimate line of defense against disturbances of acid-base balance, undergoes a complex maturation process during the transition from a fetal to an extra-uterine environment. Read More

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http://link.springer.com/10.1007/s00467-018-4142-9
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http://dx.doi.org/10.1007/s00467-018-4142-9DOI Listing
November 2018
19 Reads

Spontaneous Hyperventilation in Severe Traumatic Brain Injury: Incidence and Association with Poor Neurological Outcome.

Neurocrit Care 2019 Apr;30(2):405-413

Intensive Care Unit, Sainte Anne Military Hospital, Toulon, France.

Background: Hypocapnia induces cerebral vasoconstriction leading to a decrease in cerebral blood flow, which might precipitate cerebral ischemia. Hypocapnia can be intentional to treat intracranial hypertension or unintentional due to a spontaneous hyperventilation (SHV). SHV is frequent after subarachnoid hemorrhage. Read More

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http://dx.doi.org/10.1007/s12028-018-0639-0DOI Listing
April 2019
2 Reads

Carotid chemoreceptors have a limited role in mediating the hyperthermia-induced hyperventilation in exercising humans.

J Appl Physiol (1985) 2019 Feb 1;126(2):305-313. Epub 2018 Nov 1.

Faculty of Health and Sport Sciences, University of Tsukuba , Tsukuba , Japan.

Hyperthermia causes hyperventilation at rest and during exercise. We previously reported that carotid chemoreceptors partly contribute to the hyperthermia-induced hyperventilation at rest. However, given that a hyperthermia-induced hyperventilation markedly differs between rest and exercise, the results obtained at rest may not be representative of the response in exercise. Read More

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http://dx.doi.org/10.1152/japplphysiol.00562.2018DOI Listing
February 2019
3 Reads

Carbonic anhydrase inhibitors in patients with respiratory failure and metabolic alkalosis: a systematic review and meta-analysis of randomized controlled trials.

Crit Care 2018 Oct 29;22(1):275. Epub 2018 Oct 29.

Division of Nephrology and Hypertension, Makassed General Hospital, Beirut, Lebanon.

Background: Metabolic alkalosis is common in patients with respiratory failure and may delay weaning in mechanically ventilated patients. Carbonic anhydrase inhibitors block renal bicarbonate reabsorption, and thus reverse metabolic alkalosis. The objective of this systematic review is to assess the benefits and harms of carbonic anhydrase inhibitor therapy in patients with respiratory failure and metabolic alkalosis. Read More

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https://ccforum.biomedcentral.com/articles/10.1186/s13054-01
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http://dx.doi.org/10.1186/s13054-018-2207-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205780PMC
October 2018
16 Reads

Renal reactivity: acid-base compensation during incremental ascent to high altitude.

J Physiol 2018 Dec 28;596(24):6191-6203. Epub 2018 Oct 28.

Department of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada.

Key Points: Ascent to high altitude imposes an acid-base challenge in which renal compensation is integral for maintaining pH homeostasis, facilitating acclimatization and helping prevent mountain sicknesses. The time-course and extent of plasticity of this important renal response during incremental ascent to altitude is unclear. We created a novel index that accurately quantifies renal acid-base compensation, which may have laboratory, fieldwork and clinical applications. Read More

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http://dx.doi.org/10.1113/JP276973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292812PMC
December 2018
23 Reads

Clinical, Laboratory and Imaging Features of High Altitude Pulmonary Edema in Tibetan Plateau.

Chin Med Sci J 2018 Sep;33(3):160-173

Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China.

Objective To analyze characteristics of high altitude pulmonary edema (HAPE) in Chinese patients.Methods We performed a retrospective study of 98 patients with HAPE. We reviewed the medical records and summarized the clinical, laboratory and imaging characteristics of these cases, and compared the results on admission with those determined before discharge. Read More

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http://dx.doi.org/10.24920/11813DOI Listing
September 2018
8 Reads

The Injurious Effects of Elevated or Nonelevated Respiratory Rate during Mechanical Ventilation.

Am J Respir Crit Care Med 2019 Jan;199(2):149-157

1 Intensive Care Medicine Department, University Hospital of Heraklion, Medical School, University of Crete, Heraklion, Crete, Greece.

Respiratory rate is one of the key variables that is set and monitored during mechanical ventilation. As part of increasing efforts to optimize mechanical ventilation, it is prudent to expand understanding of the potential harmful effects of not only volume and pressures but also respiratory rate. The mechanisms by which respiratory rate may become injurious during mechanical ventilation can be distinguished in two broad categories. Read More

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https://www.atsjournals.org/doi/10.1164/rccm.201804-0726CI
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http://dx.doi.org/10.1164/rccm.201804-0726CIDOI Listing
January 2019
23 Reads

Pseudo-Renal Tubular Acidosis: Conditions Mimicking Renal Tubular Acidosis.

Adv Chronic Kidney Dis 2018 Jul;25(4):358-365

Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, MI; and Division of Pulmonary and Critical Care Medicine, Henry Ford Hospital, Detroit, MI.

Hyperchloremic metabolic acidosis, particularly renal tubular acidosis, can pose diagnostic challenges. The laboratory phenotype of a low total carbon dioxide content, normal anion gap, and hyperchloremia may be misconstrued as hypobicarbonatemia from renal tubular acidosis. Several disorders can mimic renal tubular acidosis, and these must be appropriately diagnosed to prevent inadvertent and inappropriate application of alkali therapy. Read More

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http://dx.doi.org/10.1053/j.ackd.2018.05.001DOI Listing
July 2018
7 Reads

Vagal TRPV1 activation exacerbates thermal hyperpnea and increases susceptibility to experimental febrile seizures in immature rats.

Neurobiol Dis 2018 Nov 16;119:172-189. Epub 2018 Aug 16.

Alberta Children's Hospital Research Institute, Department of Pediatrics, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada. Electronic address:

Thermal hyperpnea, a pattern of breathing during hyperthermia that is characterized by an increase in tidal volume as well as breathing frequency, is known to lead to respiratory alkalosis. Thermal hyperpnea-induced respiratory alkalosis is linked to febrile seizures (FS). The heat-sensitive transient receptor potential vanilloid-1 (TRPV1) receptors are localized in, and implicated in the heat sensitivity of peripheral and central structures involved in the respiratory response to hyperthermia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09699961183041
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http://dx.doi.org/10.1016/j.nbd.2018.08.004DOI Listing
November 2018
11 Reads

Hyperventilation Syndrome and Sustained Hyperchloremia After Kidney Transplant: Time-Sequence Swing of Acid-Base Interpretation.

Exp Clin Transplant 2018 12 17;16(6):754-756. Epub 2018 Aug 17.

Department of Anesthesiology and Pain Medicine, Yeungnam University Hospital, Daegu, Korea.

An interaction between regained renal function in a transplanted kidney and hyperventilation syndrome may interfere with correct diagnosis of acid-base status in patients with preoperative nongap acidosis. Here, we present a patient with glomerular nephritis and hyperchloremia who underwent kidney transplant. Progressively increasing bicarbonate reabsorption by the renal graft, which thereby changed the arterial carbon dioxide tension-to-bicarbonate ratio, resulted in a time-sequence swing of an acid-base interpretation despite persistent mixed respiratory alkalosis due to hyperventilation syndrome and nongap metabolic acidosis due to preexisting hyperchloremia. Read More

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http://www.ectrx.org/forms/ectrxcontentshow.php?doi_id=10.60
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http://dx.doi.org/10.6002/ect.2018.0099DOI Listing
December 2018
8 Reads

The Prevalence and Predicting Factors of Pulmonary Thromboembolism in Patients with Exacerbated Chronic Obstructive Pulmonary Disease.

Adv Respir Med 2018 Aug 15. Epub 2018 Aug 15.

Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences, North Kargar Ave. 14114, Tehran, Iran, Iran, Islamic Republic Of.

Background And Aims: The risk of pulmonary thromboembolism (PTE) in patients with exacerbated chronic obstructive pulmonary disease (e-COPD) is higher than in non-COPD states. This study aimed to evaluate the prevalence and the parameters that are critical for finding the incidence of PTE in patients with e-COPD.

Methods: This cross-sectional study was performed on 68 consecutive patients with the e-COPD, referred to the Pulmonary Disease Department at the Shariati Hospital in Tehran between 2013 and 2014. Read More

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https://journals.viamedica.pl/advances_in_respiratory_medici
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http://dx.doi.org/10.5603/ARM.a2018.0025DOI Listing
August 2018
7 Reads

Acid-base status and its clinical implications in critically ill patients with cirrhosis, acute-on-chronic liver failure and without liver disease.

Ann Intensive Care 2018 Apr 19;8(1):48. Epub 2018 Apr 19.

Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

Background: Acid-base disturbances are frequently observed in critically ill patients at the intensive care unit. To our knowledge, the acid-base profile of patients with acute-on-chronic liver failure (ACLF) has not been evaluated and compared to critically ill patients without acute or chronic liver disease.

Results: One hundred and seventy-eight critically ill patients with liver cirrhosis were compared to 178 matched controls in this post hoc analysis of prospectively collected data. Read More

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http://dx.doi.org/10.1186/s13613-018-0391-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908779PMC
April 2018
8 Reads

Accuracy of Acid-Base Diagnoses Using the Central Venous Blood Gas in the Medical Intensive Care Unit.

Nephron 2018 12;139(4):293-298. Epub 2018 Apr 12.

Renal, Electrolyte and Hypertension Division of the Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Background: Acid-base disturbances are frequent in critically ill patients. Arterial blood gas (ABG) is the gold standard in the diagnosis of these disturbances, but it is invasive with potential hazards. For patients with a central venous catheter, venous blood gas (VBG) sampling may be an alternative, less-invasive diagnostic tool. Read More

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https://www.karger.com/Article/FullText/488501
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http://dx.doi.org/10.1159/000488501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067967PMC
April 2018
13 Reads

Rescue of hyperexcitability in hippocampal CA1 neurons from Mecp2 (-/y) mouse through surface potential neutralization.

PLoS One 2018 5;13(4):e0195094. Epub 2018 Apr 5.

CNMPB (Centre for Nanoscale Microscopy and Molecular Physiology of the Brain, Cluster of Excellence 171, DFG Research Center 103), Institute of Neuro and Sensory Physiology, Georg-August-University, Göttingen, Germany.

Hyperventilation is a known feature of Rett syndrome (RTT). However, how hyperventilation is related to other RTT symptoms such as hyperexcitability is unknown. Intense breathing during hyperventilation induces hypocapnia and culminates in respiratory alkalosis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195094PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886422PMC
July 2018
3 Reads

Severe hypophosphataemia: a rare cause of postoperative muscle weakness.

BMJ Case Rep 2018 Feb 23;2018. Epub 2018 Feb 23.

Division of Anesthesiology, Mayo Clinic, Rochester, MN, USA.

We report a case of severe generalised muscle weakness in a 66-year-old man who underwent revision of left knee arthroplasty. On postoperative day 1, he developed non-focal muscle weakness and shortness of breath which progressed over a 6-hour period. Serum phosphorus level was severely low at 0. Read More

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http://dx.doi.org/10.1136/bcr-2017-221193DOI Listing
February 2018
4 Reads

Acid-base balance during muscular exercise: response to Dr. Böning and Dr. Maassen.

Eur J Appl Physiol 2018 04 22;118(4):865-866. Epub 2018 Feb 22.

Department of Anesthesiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00421-018-3825-zDOI Listing
April 2018
9 Reads

Vitamin C and sodium bicarbonate enhance the antioxidant ability of H9C2 cells and induce HSPs to relieve heat stress.

Cell Stress Chaperones 2018 07 13;23(4):735-748. Epub 2018 Feb 13.

College of Veterinary Medicine, Nanjing Agricultural University, Weigang 1, Nanjing, 210095, China.

Heat stress is exacerbated by global warming and affects human and animal health, leading to heart damage caused by imbalances in reactive oxygen species (ROS) and the antioxidant system, acid-base chemistry, electrolytes and respiratory alkalosis. Vitamin C scavenges excess ROS, and sodium bicarbonate maintains acid-base and electrolyte balance, and alleviates respiratory alkalosis. Herein, we explored the ability of vitamin C alone and in combination with equimolar sodium bicarbonate (Vitamin C-Na) to stimulate endogenous antioxidants and heat shock proteins (HSPs) to relieve heat stress in H9C2 cells. Read More

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http://dx.doi.org/10.1007/s12192-018-0885-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045543PMC
July 2018
8 Reads

The effect of metabolic alkalosis on the ventilatory response in healthy subjects.

Respir Physiol Neurobiol 2018 02 4;249:47-53. Epub 2018 Jan 4.

Department of Critical Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Intensive Care Medicine, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:

Background: Patients with acute respiratory failure may develop respiratory acidosis. Metabolic compensation by bicarbonate production or retention results in posthypercapnic alkalosis with an increased arterial bicarbonate concentration. The hypothesis of this study was that elevated plasma bicarbonate levels decrease respiratory drive and minute ventilation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15699048173033
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http://dx.doi.org/10.1016/j.resp.2018.01.002DOI Listing
February 2018
11 Reads

S737F is a new CFTR mutation typical of patients originally from the Tuscany region in Italy.

Ital J Pediatr 2018 Jan 3;44(1). Epub 2018 Jan 3.

Centro Regionale Toscano per la Fibrosi Cistica, Azienda Ospedaliero-Universitaria Meyer, Via Gaetano Pieraccini 24, 50141, Florence, Italy.

Background: An increasing number of patients have been described as having a number of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) variants for which it lacks a clear genotype-phenotype correlation. We assesses the clinical features of patients bearing the S737F (p.Ser737Phe) CFTR missense variant and evaluated the residual function of CFTR protein on nasal epithelial cells (NEC). Read More

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http://dx.doi.org/10.1186/s13052-017-0443-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753463PMC
January 2018
13 Reads

Oxidative stress in urea cycle disorders: Findings from clinical and basic research.

Clin Chim Acta 2018 Feb 1;477:121-126. Epub 2017 Dec 1.

Curso de Especialização em Análises Clínicas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre-RS, Brazil; Programa de Pós-Graduação em Ciências Biológicas - Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre-RS, Brazil; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre-RS, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre-RS, Brazil. Electronic address:

Inborn errors of metabolism (IEM) comprise a group of over 600 disorders, each with a specific metabolic impairment due to a genetic defect. Urea cycle disorders (UCD) are IEM that affect the nitrogen disposal system, leading to hyperammonemia and the accumulation of other toxic metabolites in tissues of affected patients. UCD arise from mutations in the genes coding any of the enzymes participating in the urea cycle, either directly or as regulators of this pathway, causing severe respiratory alkalosis. Read More

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http://dx.doi.org/10.1016/j.cca.2017.11.041DOI Listing
February 2018
8 Reads

Safety and efficacy of regional citrate anticoagulation in continuous blood purification treatment of patients with multiple organ dysfunction syndrome.

Braz J Med Biol Res 2017 Nov 17;51(1):e6378. Epub 2017 Nov 17.

Intensive Care Units, Branch of the First Affiliated Hospital of Xinjiang Medical University, Changji, Xinjiang, China.

The aim of this study was to discuss the safety and efficacy of regional citrate anticoagulation (RCA) on continuous blood purification (CBP) during the treatment of multiple organ dysfunction syndrome (MODS). Thirty-five patients with MODS were divided into two groups: the local citrate anticoagulation (RCA) group, and the heparin-free blood purification (hfBP) group. The MODS severity was assessed according to Marshall's MODS score criteria. Read More

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http://dx.doi.org/10.1590/1414-431X20176378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685057PMC
November 2017
10 Reads

Salicylate Intoxication in an Infant: A Case Report.

Drug Saf Case Rep 2017 Nov 27;4(1):23. Epub 2017 Nov 27.

Intensive Care Unit, Paediatric Department, Hospital of Santa Maria, Lisbon, Portugal.

In children, the most common cause of an elevated anion gap (AG) with ketonemia, ketonuria, hyperglycemia, and glycosuria is diabetic ketoacidosis. However, when the clinical history is not clear, other causes must be considered. A 9-month-old girl was transferred to our pediatric intensive care unit (PICU) because of severe metabolic acidosis. Read More

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http://dx.doi.org/10.1007/s40800-017-0065-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704028PMC
November 2017
12 Reads

Interdependent feedback regulation of breathing by the carotid bodies and the retrotrapezoid nucleus.

J Physiol 2018 Aug 27;596(15):3029-3042. Epub 2017 Dec 27.

Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.

The retrotrapezoid nucleus (RTN) regulates breathing in a CO - and state-dependent manner. RTN neurons are glutamatergic and innervate principally the respiratory pattern generator; they regulate multiple aspects of breathing, including active expiration, and maintain breathing automaticity during non-REM sleep. RTN neurons encode arterial /pH via cell-autonomous and paracrine mechanisms, and via input from other CO -responsive neurons. Read More

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http://dx.doi.org/10.1113/JP274357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068251PMC
August 2018
8 Reads

Leigh syndrome in individuals bearing m.9185T>C MTATP6 variant. Is hyperventilation a factor which starts its development?

Metab Brain Dis 2018 02 7;33(1):191-199. Epub 2017 Nov 7.

Department of Medical Genetics, The Children's Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730, Warsaw, Poland.

Leigh syndrome (LS), subacute necrotizing encephalomyelopathy is caused by various genetic defects, including m.9185T>C MTATP6 variant. Mechanism of LS development remains unknown. Read More

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http://dx.doi.org/10.1007/s11011-017-0122-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769826PMC
February 2018
24 Reads

The Role of Sodium Bicarbonate in the Management of Some Toxic Ingestions.

Int J Nephrol 2017 8;2017:7831358. Epub 2017 Aug 8.

Department of Medicine, University of Kentucky College of Medicine, Lexington, KY, USA.

Adverse reactions to commonly prescribed medications and to substances of abuse may result in severe toxicity associated with increased morbidity and mortality. According to the Center for Disease Control, in 2013, at least 2113 human fatalities attributed to poisonings occurred in the United States of America. In this article, we review the data regarding the impact of systemic sodium bicarbonate administration in the management of certain poisonings including sodium channel blocker toxicities, salicylate overdose, and ingestion of some toxic alcohols and in various pharmacological toxicities. Read More

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http://dx.doi.org/10.1155/2017/7831358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591930PMC
August 2017
18 Reads

Changes in acid-base and ion balance during exercise in normoxia and normobaric hypoxia.

Eur J Appl Physiol 2017 Nov 15;117(11):2251-2261. Epub 2017 Sep 15.

Department of Anesthesiology, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.

Purpose: Both exercise and hypoxia cause complex changes in acid-base homeostasis. The aim of the present study was to investigate whether during intense physical exercise in normoxia and hypoxia, the modified physicochemical approach offers a better understanding of the changes in acid-base homeostasis than the traditional Henderson-Hasselbalch approach.

Methods: In this prospective, randomized, crossover trial, 19 healthy males completed an exercise test until voluntary fatigue on a bicycle ergometer on two different study days, once during normoxia and once during normobaric hypoxia (12% oxygen, equivalent to an altitude of 4500 m). Read More

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http://link.springer.com/10.1007/s00421-017-3712-z
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http://dx.doi.org/10.1007/s00421-017-3712-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640730PMC
November 2017
16 Reads

Swimming Three Ice Miles within Fifteen Hours.

Chin J Physiol 2017 Aug;60(4):197-206

Gesundheitszentrum St. Gallen, St. Gallen, Switzerland.

Ice Mile swimming (1608 m in water of below 5 °Celsius) is becoming increasingly popular. This case study aimed to identify body core temperature and selected haematological and biochemical parameters before and after repeated Ice Miles. An experienced ice swimmer completed three consecutive Ice Miles within 15 h. Read More

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http://dx.doi.org/10.4077/CJP.2017.BAF467DOI Listing
August 2017
12 Reads

A short-term supranutritional vitamin E supplementation alleviated respiratory alkalosis but did not reduce oxidative stress in heat stressed pigs.

Asian-Australas J Anim Sci 2018 Feb 16;31(2):263-269. Epub 2017 Aug 16.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville 3010, Australia.

Objective: Heat stress (HS) triggers oxidative stress and respiratory alkalosis in pigs. The objective of this experiment was to study whether a short-term supranutritional amount of dietary vitamin E (VE) can mitigate oxidative stress and respiratory alkalosis in heat-stressed pigs.

Methods: A total of 24 pigs were given either a control diet (17 IU/kg VE) or a high VE (200 IU/kg VE; HiVE) diet for 14 d, then exposed to thermoneutral (TN; 20°C, 45% humidity) or HS (35°C, 35% to 45% humidity, 8 h daily) conditions for 7 d. Read More

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http://www.ajas.info/journal/view.php?doi=10.5713/ajas.17.02
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http://dx.doi.org/10.5713/ajas.17.0256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767509PMC
February 2018
21 Reads

[Disorders of water and electrolyte metabolism and changes in acid-base balance in patients with ascitic liver cirrhosis].

Cas Lek Cesk 2017 ;156(3):150-152

In patients with advanced cirrhosis with ascites disorders of water and electrolyte metabolism are often present and they are associated with changes in acid-base balance. These changes can be very complicated, their diagnosis and treatment difficult. Dilutional hyponatremia is the most common disorder. Read More

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January 2017
14 Reads

Immune-inflammatory activation after a single laparotomy in a rat model: effect of adenosine, lidocaine and Mg infusion to dampen the stress response.

Innate Immun 2017 07;23(5):482-494

Heart, Trauma and Sepsis Research Laboratory, College of Medicine and Dentistry, James Cook University, Queensland, Australia.

Our aim was to examine the effect of low-volume 0.9% NaCl adenosine, lidocaine and Mg (ALM) 'drip' on early immune-inflammatory activation after a single laparotomy with no further manipulation. Male Sprague-Dawley rats were anesthetized and randomly assigned to one of the groups, baseline, 1 h infusion 0. Read More

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http://dx.doi.org/10.1177/1753425917718921DOI Listing
July 2017
11 Reads

Acid-base disorders in liver disease.

J Hepatol 2017 11 3;67(5):1062-1073. Epub 2017 Jul 3.

Department of Respiratory and Critical Care Medicine, Otto Wagner Spital, Vienna, Austria. Electronic address:

Alongside the kidneys and lungs, the liver has been recognised as an important regulator of acid-base homeostasis. While respiratory alkalosis is the most common acid-base disorder in chronic liver disease, various complex metabolic acid-base disorders may occur with liver dysfunction. While the standard variables of acid-base equilibrium, such as pH and overall base excess, often fail to unmask the underlying cause of acid-base disorders, the physical-chemical acid-base model provides a more in-depth pathophysiological assessment for clinical judgement of acid-base disorders, in patients with liver diseases. Read More

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http://dx.doi.org/10.1016/j.jhep.2017.06.023DOI Listing
November 2017
29 Reads

Acetazolamide Use in Severe Chronic Obstructive Pulmonary Disease. Pros and Cons.

Ann Am Thorac Soc 2017 Jul;14(7):1086-1093

University of Washington and Department of Veterans Affairs, Seattle, Washington.

Acetazolamide is a carbonic anhydrase (CA) inhibitor sometimes used as a respiratory stimulant for patients with chronic obstructive pulmonary disease (COPD) with the goal of improving oxygenation, reducing carbon dioxide retention, and aiding liberation from mechanical ventilation and/or attempting to correct a metabolic alkalosis. However, the net effect of CA inhibition is multifactorial and complex, because CA is inhibited in many tissues that may negatively affect the patient with lung disease. The full impact of acetazolamide and other CA inhibitors depends critically on dosing, age, and pulmonary, renal, hepatic, hematological, and respiratory muscle function and reserves. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201701-016FRDOI Listing
July 2017
7 Reads

Cystic fibrosis prevalence among a group of high-risk children in the main referral children hospital in Iran.

J Educ Health Promot 2017 5;6:54. Epub 2017 Jun 5.

Department of Pediatric Pulmonology, Child Growth and Development Research Center, Faculty of Medicine, Research Institute for Primordial Prevention of Noncommunicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Knowledge about cystic fibrosis (CF) in Iran is very limited. The objective of this study was to determine the prevalence of CF among a group of high-risk children with suggestive clinical features in the main referral hospital in Iran.

Materials And Methods: This study children consisted of 505 patients who had presented with one or more of the following symptoms: chronic or recurrent respiratory symptoms, gastrointestinal symptoms as rectal prolapse, steatorrhea, hepatobiliary disease as prolonged jaundice, failure to thrive, hyperglycemia and glycosuria, hypochloremic metabolic alkalosis, hypoprothrombinemia, anemia or edema, and positive family history of CF. Read More

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http://dx.doi.org/10.4103/jehp.jehp_80_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470295PMC
June 2017
16 Reads

Water, electrolyte, acid-base, and trace elements alterations in cirrhotic patients.

Int Urol Nephrol 2018 Jan 12;50(1):81-89. Epub 2017 Jun 12.

Department of Medicine, Geffen School of Medicine, UCLA, Los Angeles, CA, USA.

Chronic hepatic patients, and particularly those suffering from cirrhosis, are predisposed to different sort of water, electrolyte, acid-base, and trace elements disorders due to their altered liver function, and also to their exposition to infectious, inflammatory, oncologic, and pharmacologic variables whose combination undermines their homeostatic capability. Hyponatremia, hypokalemia, hyperkalemia, hypocalcemia, metabolic acidosis, respiratory, and metabolic alkalosis are the main internal milieu alterations in this group. Read More

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http://dx.doi.org/10.1007/s11255-017-1614-yDOI Listing
January 2018
27 Reads

Metabolic Acidosis or Respiratory Alkalosis? Evaluation of a Low Plasma Bicarbonate Using the Urine Anion Gap.

Am J Kidney Dis 2017 Sep 7;70(3):440-444. Epub 2017 Jun 7.

Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, CT.

Hypobicarbonatemia, or a reduced bicarbonate concentration in plasma, is a finding seen in 3 acid-base disorders: metabolic acidosis, chronic respiratory alkalosis and mixed metabolic acidosis and chronic respiratory alkalosis. Hypobicarbonatemia due to chronic respiratory alkalosis is often misdiagnosed as a metabolic acidosis and mistreated with the administration of alkali therapy. Proper diagnosis of the cause of hypobicarbonatemia requires integration of the laboratory values, arterial blood gas, and clinical history. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02726386173069
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http://dx.doi.org/10.1053/j.ajkd.2017.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572668PMC
September 2017
17 Reads

Sedative and cardiorespiratory effects of detomidine constant rate infusion in sheep.

Lab Anim 2018 Feb 8;52(1):51-58. Epub 2017 Jun 8.

Department of Veterinary Medicine, Federal University of Goiás, Brazil.

The use of sheep in experiments is widespread and is increasing worldwide, and so is the need to develop species-specific anaesthetic techniques to ensure animal safety. Previous studies have mentioned several protocols involving the administration of alpha-2 adrenergic agonists in sheep; however, assessment of the efficacy and safety of these infusion techniques is still relatively new. Thus, the aim of the present study is to assess the effectiveness of detomidine constant rate infusion (CRI) in sheep by measuring the cardiovascular and respiratory parameters, blood gas variables and sedation scores. Read More

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http://dx.doi.org/10.1177/0023677217714013DOI Listing
February 2018
29 Reads

Effect of voluntary hypocapnic hyperventilation or moderate hypoxia on metabolic and heart rate responses during high-intensity intermittent exercise.

Eur J Appl Physiol 2017 Aug 19;117(8):1573-1583. Epub 2017 May 19.

Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba City, Ibaraki, 305-8574, Japan.

Purpose: To investigate the effect of voluntary hypocapnic hyperventilation or moderate hypoxia on metabolic and heart rate responses during high-intensity intermittent exercise.

Methods: Ten males performed three 30-s bouts of high-intensity cycling [Ex1 and Ex2: constant-workload at 80% of the power output in the Wingate anaerobic test (WAnT), Ex3: WAnT] interspaced with 4-min recovery periods under normoxic (Control), hypocapnic or hypoxic (2500 m) conditions. Hypocapnia was developed through voluntary hyperventilation for 20 min prior to Ex1 and during each recovery period. Read More

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http://dx.doi.org/10.1007/s00421-017-3646-5DOI Listing
August 2017
43 Reads

[Procedural analysis of acid-base balance disorder: case serials in 4 patents].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2017 May;29(5):436-441

Department of Nephrology, Shuyang People's Hospital, Suqian 223600, Jiangsu, China (Ma CY); Teaching Section of Mathematics, China Medical University, Shenyang 110000, Liaoning, China (Wang GJ). Corresponding author: Wang Guijie, Email:

Objective: To establish the standardization process of acid-base balance analysis, analyze cases of acid-base balance disorder with the aid of acid-base balance coordinate graph.

Methods: The acid-base balance theory were reviewed systematically on recent research progress, and the important concepts, definitions, formulas, parameters, regularity and inference in the analysis of acid-base balance were studied. The analysis of acid-base balance disordered processes and steps were figured. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2017.05.010DOI Listing
May 2017
7 Reads

Renal manifestations of primary mitochondrial disorders.

Biomed Rep 2017 05 12;6(5):487-494. Epub 2017 Apr 12.

Paulista de Medicina School, Federal University of São Paulo, Primeiro Andar CEP, São Paulo 04039-032, SP, Brazil.

The aim of the present review was to summarize and discuss previous findings concerning renal manifestations of primary mitochondrial disorders (MIDs). A literature review was performed using frequently used databases. The study identified that primary MIDs frequently present as mitochondrial multiorgan disorder syndrome (MIMODS) at onset or in the later course of the MID. Read More

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http://dx.doi.org/10.3892/br.2017.892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431253PMC
May 2017
36 Reads

Electrolyte and Acid-Base Disturbances in End-Stage Liver Disease: A Physiopathological Approach.

Dig Dis Sci 2017 08 13;62(8):1855-1871. Epub 2017 May 13.

Department of Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, 14080, Mexico City, Mexico.

Electrolyte and acid-base disturbances are frequent in patients with end-stage liver disease; the underlying physiopathological mechanisms are often complex and represent a diagnostic and therapeutic challenge to the physician. Usually, these disorders do not develop in compensated cirrhotic patients, but with the onset of the classic complications of cirrhosis such as ascites, renal failure, spontaneous bacterial peritonitis and variceal bleeding, multiple electrolyte, and acid-base disturbances emerge. Hyponatremia parallels ascites formation and is a well-known trigger of hepatic encephalopathy; its management in this particular population poses a risky challenge due to the high susceptibility of cirrhotic patients to osmotic demyelination. Read More

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http://dx.doi.org/10.1007/s10620-017-4597-8DOI Listing
August 2017
29 Reads