2,483 results match your criteria Respiratory Alkalosis


[CFTR gene variations and phenotypes in seven children].

Zhonghua Er Ke Za Zhi 2021 Aug;59(8):689-694

Department of Respiration, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.

To analyze the cystic fibrosis transmembrane conductance regulator (CFTR) gene variations and phenotypes in 7 Chinese children. In this retrospective study, the data of 7 children with CFTR gene variations admitted to Children's Hospital of Chongqing Medical University from December 2013 to October 2020 were extracted. The general information, clinical manifestations, gene variations, diagnosis and treatment were summarized. Read More

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Acquired Bartter-like Syndrome Presenting with Polyuria and Reversible Hypokalemia Associated with Colistin Use in a Critically Ill Pediatric Patient.

Indian J Crit Care Med 2021 Jul;25(7):822-824

Department of Pediatric Intensive Care, Cukurova University, Faculty of Medicine, Adana, Turkey.

We report a case of an acquired Bartter-like syndrome (BLS) after 3 days of treatment initiation and improved after discontinuation of colistin therapy in pediatric intensive care unit. A 2-month-old girl with spinal muscular atrophy type 1 who had respiratory distress received colistin therapy with a dose of 5 mg/kg/day for complex isolation from endotracheal aspirate on the 12 day follow-up. Polyuria (6 mL/kg/hour) in the presence of normal blood pressure and hypokalemic metabolic alkalosis were developed on the 3 day of colistin treatment. Read More

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Effect of induced acute metabolic alkalosis on the V̇/V̇CO response to exercise in healthy adults.

Respir Physiol Neurobiol 2021 Jul 10;294:103740. Epub 2021 Jul 10.

Clinical Exercise & Respiratory Physiology Laboratory, Department of Kinesiology & Physical Education, McGill University, Montreal, Quebec, Canada; Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada. Electronic address:

We tested the hypothesis that increasing the respiratory control systems' arterial PCO equilibrium point via induced acute metabolic alkalosis by ingestion of sodium bicarbonate (NaHCO, 0.3 g/kg) would decrease the ventilatory equivalent for CO (V̇/V̇CO) at its lowest point ("nadir") during constant-load cycle exercise testing performed at 80 % of peak power output in 18 healthy young adults. Compared to the sodium chloride (4 g) control condition, ingestion of NaHCO: increased arterialized venous pH, HCO- and PCO at rest by 0. Read More

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Left displacement of the abomasum in a reticulated giraffe bull in managed care.

J Vet Diagn Invest 2021 Jun 24:10406387211027845. Epub 2021 Jun 24.

Michigan State University Veterinary Diagnostic Laboratory, Lansing, MI, USA.

A 10-y-old giraffe () bull developed colic after a 3-mo history of reduced feed consumption. Physical examination and management were performed with 2 standing sedations. The giraffe developed metabolic alkalosis and progressive pre-renal azotemia followed by compensatory respiratory acidosis and paradoxical aciduria. Read More

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Acid base disorders in patients with COVID-19.

Int Urol Nephrol 2021 Jun 11. Epub 2021 Jun 11.

Clinic of Infectious Diseases, University Hospital of Modena, Modena, Italy.

Purpose: Acid-base derangement has been poorly described in patients with coronavirus disease 2019 (COVID-19). Considering the high prevalence of pneumonia and kidneys injury in COVID-19, frequent acid-base alterations are expected in patients admitted with SARS-Cov-2 infection. The study aimed to assess the prevalence of acid-base disorders in symptomatic patients with a diagnosis of COVID-19. Read More

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Alterations in arterial CO rather than pH affect the kinetics of neurovascular coupling in humans.

J Physiol 2021 Aug 29;599(15):3663-3676. Epub 2021 Jun 29.

Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, V1V 1V7, Canada.

Key Points: We investigated the influence of arterial ( ) with and without acute experimental metabolic alkalosis on neurovascular coupling (NVC). We assessed stepwise iso-oxic alterations in prior to and following intravenous NaHCO to acutely elevate arterial pH and [HCO ]. The NVC response was not altered following NaHCO between stepwise stages; therefore, NVC is acutely mediated by rather than the prevailing arterial [H ]/pH. Read More

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Regulation of cerebral blood flow by arterial PCO independent of metabolic acidosis at 5050 m.

J Physiol 2021 Jul 24;599(14):3513-3530. Epub 2021 Jun 24.

Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada.

Key Points: We investigated the influence of arterial PCO (PaCO ) with and without experimentally altered pH on cerebral blood flow (CBF) regulation at sea level and with acclimatization to 5050 m. At sea level and high altitude, we assessed stepwise alterations in PaCO following metabolic acidosis (via 2 days of oral acetazolamide; ACZ) with and without acute restoration of pH (via intravenous sodium bicarbonate; ACZ+HCO ). Total resting CBF was unchanged between trials at each altitude even though arterial pH and [HCO ] (i. Read More

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Elevated sweat chloride test: is it always cystic fibrosis?

Ital J Pediatr 2021 May 14;47(1):112. Epub 2021 May 14.

Department of Translational Medical Sciences, Cystic Fibrosis Center, University Federico II, Naples, Italy.

Background: The sweat chloride test (ST) is the gold standard for cystic fibrosis (CF) diagnosis in symptomatic patients, within the newborn screening and in the follow-up of CF patients during molecular therapies. However, false positives have been reported in patients with different diseases. We describe and discuss 4 cases due to different clinical conditions in which we recorded false positive ST, and the test remained altered for a period of varying length. Read More

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Association Between Respiratory Alkalosis and the Prognosis of COVID-19 Patients.

Front Med (Lausanne) 2021 26;8:564635. Epub 2021 Apr 26.

Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.

The aim of the study was to describe the clinical characteristics of patients with or without respiratory alkalosis, and analyze the relationship of respiratory alkalosis and the outcome of adult coronavirus disease 2019 (COVID-19) patients. Clinical and laboratory data of adult COVID-19 patients in a single center in China, were retrospectively collected and analyzed. The Kaplan-Meier (KM) curve and cox regression were adopted to analyze the association between respiratory alkalosis and prognosis of COVID-19 patients. Read More

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A rare case of ectopic ACTH syndrome with rhabdomyolysis.

BMC Endocr Disord 2021 May 10;21(1):98. Epub 2021 May 10.

Department of Endocrinology and Metabolism, The First Affiliated Hospital of Xi'an Jiaotong University, No.277 West Yanta Road, 710061, Xi'an, People's Republic of China.

Background: Manifestations of hypokalaemia in ectopic adrenocorticotropic hormonesyndrome(EAS) vary from mild muscle weakness to life-threatening arrhythmia. Herein, we present a rare case of EAS with concomitant rhabdomyolysis(RM) as a result of intractable hypokalaemia.

Case Presentation: A 64-year-old man was admitted for limb weakness and facial hyperpigmentation for 2 weeks. Read More

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Amitraz toxicosis in 3 dogs after being in a rice field.

J Vet Emerg Crit Care (San Antonio) 2021 Jul 30;31(4):516-520. Epub 2021 Apr 30.

California Animal Health and Food Safety Lab, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.

Objective: To describe the clinical course and novel biochemical findings in 3 dogs with amitraz toxicosis.

Case Series Summary: Three Labrador Retrievers developed acute onset obtundation to stupor after being in a rice field. On admittance to the hospital, they all displayed bradycardia, hyperglycemia, hyperlactatemia, respiratory acidosis, and metabolic alkalosis. Read More

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The co-occurrence of leukemoid reaction and hypercalcemia in a patient with endometrial cancer: A case report and literature review.

Sci Prog 2021 Apr-Jun;104(2):368504211004028

Shanghai First Maternity and Infant Hospital, Tongji University, School of Medicine, Pudong, Shanghai, China.

Paraneoplastic syndromes are rarely seen in gynecological tumors especially in endometrial cancer. Early identification of paraneoplastic syndromes plays a significant role in the treatment and prognosis of cancer. Here, we reported a rare case with endometrial cancer with a 2. Read More

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Central neurogenic hyperventilation secondary to suspected metastatic renal cell carcinoma.

Am J Emerg Med 2021 Mar 2. Epub 2021 Mar 2.

Lehigh Valley Health Network, Department of Emergency, Hospital Medicine/USF Morsani College of Medicine, Cedar Crest Boulevard & I-78, Allentown, PA 18103, USA.

Central neurogenic hyperventilation (CNH) is a neurogenic disorder rarely described within Emergency Medicine literature. CNH is a primary cause of hyperventilation, most commonly due to primary central nervous system neoplasms. Patient presentation varies based on the underlying cause, and may present with a sole chief complaint of dyspnea. Read More

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Time course and magnitude of ventilatory and renal acid-base acclimatization following rapid ascent to and residence at 3,800 m over nine days.

J Appl Physiol (1985) 2021 06 11;130(6):1705-1715. Epub 2021 Mar 11.

Department of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada.

Rapid ascent to high altitude imposes an acute hypoxic and acid-base challenge, with ventilatory and renal acclimatization countering these perturbations. Specifically, ventilatory acclimatization improves oxygenation, but with concomitant hypocapnia and respiratory alkalosis. A compensatory, renally mediated relative metabolic acidosis follows via bicarbonate elimination, normalizing arterial pH(a). Read More

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Automatic real-time analysis and interpretation of arterial blood gas sample for Point-of-care testing: Clinical validation.

PLoS One 2021 10;16(3):e0248264. Epub 2021 Mar 10.

External Consultant, Ingeniero de Caminos, Canales y Puertos e Ingeniero Técnico de Obras Públicas.

Background: Point-of-care arterial blood gas (ABG) is a blood measurement test and a useful diagnostic tool that assists with treatment and therefore improves clinical outcomes. However, numerically reported test results make rapid interpretation difficult or open to interpretation. The arterial blood gas algorithm (ABG-a) is a new digital diagnostics solution that can provide clinicians with real-time interpretation of preliminary data on safety features, oxygenation, acid-base disturbances and renal profile. Read More

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Hyperventilation Leading to Transient T-wave Inversion Mimicking Unstable Angina.

Cureus 2021 Jan 29;13(1):e12980. Epub 2021 Jan 29.

Cardiology, 7 Air Force Hospital, Kanpur, IND.

T-wave inversion in ECG is very frequent and concerning finding as it is often associated with life-threatening conditions. There are numerous conditions mentioned in the literature for transient T-wave inversion such as acute coronary syndrome, cardiac memory T-wave, subarachnoid hemorrhage, electroconvulsive therapy, hyperventilation and indeterminate origin. Hyperventilation is already known as a cause of transient T-wave inversion; however, it is often forgotten in modern clinical settings. Read More

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January 2021

Is N95 face mask linked to dizziness and headache?

Int Arch Occup Environ Health 2021 Mar 1. Epub 2021 Mar 1.

Departments of Biostatistics and Medical Informatics, Kahramanmaraş Sutcu Imam University Faculty of Medicine, Kahramanmaraş, Turkey.

Objectives: During the COVID-19 pandemic, healthcare professionals are recommended to use PPE to prevent the transmission of disease. Healthcare workers who use N95 FFR, which has an important place, experience complaints such as headache and dizziness. In this study, we plan to find the cause of these complaints and aim to clarify whether they are associated with the use of N95 mask. Read More

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Effects of emersion on acid-base regulation, osmoregulation, and nitrogen physiology in the semi-terrestrial mangrove crab, Helice formosensis.

J Comp Physiol B 2021 May 22;191(3):455-468. Epub 2021 Feb 22.

Department of Biological Sciences, University of Manitoba, Winnipeg, MB, Canada.

Emersion limits water availability and impairs the gill function of water-breathing animals resulting in a reduced capacity to regulate respiratory gas exchange, acid-base balance, and nitrogenous waste excretion. Semi-terrestrial crustaceans such as Helice formosensis mitigate these physiological consequences by modifying and recycling urine and branchial water shifting some branchial workload to the antennal glands. To investigate how this process occurs, Helice formosensis were emersed for up to 160 h and their hemolymph and urinary acid-base, nitrogenous waste, free amino acids, and osmoregulatory parameters were investigated. Read More

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Comparative analysis between available challenge tests in the hyperventilation syndrome.

Respir Med 2021 04 12;179:106329. Epub 2021 Feb 12.

Department of Pulmonology, Jolimont Hospital, 159 Rue Ferrer, 7100, La Louvière, Belgium.

Background: The hyperventilation syndrome (HVS) is characterized by somatic/ psychological symptoms due to sustained hypocapnia and respiratory alkalosis without any organic disease.

Objective: The purpose of this study was to compare ventilatory parameters and symptoms reproducibility during the hyperventilation provocation test (HVPT) and cardiopulmonary exercise test (CPET) as diagnostic tools in patients with HVS, and to identify the most frequent etiologies of the HVS by a systematic assessment.

Methods: After exclusion of organic causes, 59 patients with HVS according to Nijmegen's questionnaire (NQ) score ≥23 with associated hypocapnia (PaCO/PET<35 mm Hg) were studied. Read More

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A case report of streptococcal toxic shock syndrome caused by Streptococcus mitis in a healthy adult.

BMC Infect Dis 2021 Feb 6;21(1):154. Epub 2021 Feb 6.

Department of Gynecology, Affiliated Hospital of Jining Medical University, N89 Guhuai Road, Jining, 272029, Shandong Province, China.

Background: Streptococcal toxic shock syndrome (STSS) is an acute, multisystem and toxin-mediated disease that usually causes shock and multiple organ failure in the early stages of its clinical course. It is associated with a substantial increase in mortality rate. The disease has been associated with invasive group A Streptococcus and is rarely caused by Streptococcus mitis (S. Read More

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February 2021

Correlation of cerebellar granular layer autolysis with ante-mortem systemic acid-base status.

Cell Tissue Bank 2021 Feb 1. Epub 2021 Feb 1.

University of Texas Health Science Center San Antonio, San Antonio, USA.

Research in neuroscience relies heavily upon postmortem human brain tissue. Cerebellar granular layer autolysis (GLA) is a surrogate marker for the quality of such tissue and suitability for molecular analysis. GLA is associated with reduced brain tissue pH. Read More

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February 2021

Clinical Utility of Venous Blood Gas Analysis for the Evaluation of Psychogenic Hyperventilation in the Emergency Department.

Cureus 2020 Dec 25;12(12):e12273. Epub 2020 Dec 25.

Division of General Medicine, Center for Community Medicine, Jichi Medical University School of Medicine, Shimotsuke, JPN.

Background Patients with psychogenic hyperventilation frequently visit emergency departments (EDs). Arterial blood gas (ABG) analysis is performed to evaluate patients with dyspnea. This may show respiratory alkalosis in patients with hyperventilation. Read More

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December 2020

Clinical Approach to a Patient With an Acid-Base Disturbance.

Am J Kidney Dis 2021 02;77(2):A9-A11

Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; Nephrology Center of Maryland, Baltimore, MD.

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February 2021

Effects of Prior Voluntary Hyperventilation on the 3-min All-Out Cycling Test in Men.

Med Sci Sports Exerc 2021 Jul;53(7):1482-1494

Exercise and Health Research Group, Sport, Health and Performance Enhancement (SHAPE) Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UNITED KINGDOM.

Introduction: The ergogenic effects of respiratory alkalosis induced by prior voluntary hyperventilation (VH) are controversial. This study examined the effects of prior VH on derived parameters from the 3-min all-out cycling test (3MT).

Methods: Eleven men ( = 46 ± 8 mL·kg-1·min-1) performed a 3MT preceded by 15 min of rest (CONT) or VH ( = 38 ± 5 L·min-1) with PETCO2 reduced to 21 ± 1 mm Hg (HYP). Read More

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COVID-19 myocarditis and postinfection Bell's palsy.

BMJ Case Rep 2021 Jan 11;14(1). Epub 2021 Jan 11.

Department of Clinical Science, Universitetet i Bergen, Bergen, Hordaland, Norway

Here we present the case of a 37-year-old previously healthy man who developed fever, headache and a unilateral, painful neck swelling while working offshore. He had no known contact with anyone with COVID-19; however, due to the ongoing pandemic, a nasopharyngeal swab was performed, which was positive for the virus. After transfer to hospital for assessment his condition rapidly deteriorated, requiring admission to intensive care for COVID-19 myocarditis. Read More

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January 2021

Tetany Exacerbating Heart Failure: A Case Report.

Cureus 2021 Jan 4;13(1):e12467. Epub 2021 Jan 4.

Cardiology, Shimane University Faculty of Medicine, Izumo, JPN.

Tetany is characterized by numbness and stiffness in the hands and feet caused by hypocalcemia, hypomagnesemia, and hyperventilatory alkalosis, primarily at peripheral neuromuscular junctions. Although hypocalcemia is common in critically ill patients, its diagnosis of hypocalcemia is complicated and sometimes overlooked. We encountered an 82-year-old woman with tetany that exacerbated heart failure. Read More

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January 2021

The physiological response to digestion in snakes: A feast for the integrative physiologist.

Comp Biochem Physiol A Mol Integr Physiol 2021 04 2;254:110891. Epub 2021 Jan 2.

Zoophysiology, Department of Biology, Aarhus University, Universitetsparken, 8000 Aarhus C, Denmark.

Many snakes can subdue and swallow very large prey after many months of fasting. The functional capacity and the mass of the gastrointestinal organs regress during fasting, but are quickly restored upon feeding. This phenotypic flexibility appears to be energetically inexpensive, and represents a key adaptation that enables snakes to match digestive performance without compromising bodily energy stores prior to nutrient absorption. Read More

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Respiratory alkalinization and posterior cerebral artery dilatation predict acute mountain sickness severity during 10 h normobaric hypoxia.

Exp Physiol 2021 Jan;106(1):175-190

Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

New Findings: What is the central question of this study? The pathophysiology of acute mountain sickness (AMS), involving the respiratory, renal and cerebrovascular systems, remains poorly understood. How do the early adaptations in these systems during a simulated altitude of 5000 m relate to AMS risk? What is the main finding and its importance? The rate of blood alkalosis and cerebral artery dilatation predict AMS severity during the first 10 h of exposure to a simulated altitude of 5000 m. Slow metabolic compensation by the kidneys of respiratory alkalosis attributable to a brisk breathing response together with excessive brain blood vessel dilatation might be involved in early development of AMS. Read More

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January 2021

Impact of different exercise intensities on pregnant rats and on their offspring.

An Acad Bras Cienc 2020 14;92(4):e20191572. Epub 2020 Dec 14.

Programa de Pós-Graduação em Tocoginecologia, Universidade Estadual Paulista/ UNESP, Laboratório de Pesquisa Experimental em Ginecologia e Obstetrícia, Distrito de Rubião Jr, s/n, 18618-970 Botucatu, SP, Brazil.

This study aimed at evaluating the levels of different maternal exercise intensities on maternal and fetal outcomes. Wistar rats were mated and the pregnant rats were distributed into four experimental groups (n = 13 animals/group): Control (Not exercise group - 0% of the anaerobic threshold- AT), mild (20%), moderate (80%), and heavy-exercise intensity (140% of AT). These AT were matched to the load of 0, 1, 4 and 7% of the body weight of the animal related to swimming-induced physical intensity. Read More

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December 2020

Kidney Physiology in Pregnancy.

Adv Chronic Kidney Dis 2020 11;27(6):449-454

Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, NY, NY.

A woman's body undergoes a myriad of changes throughout the course of a normal gestation. The kidneys play a central role in driving adjustments that guarantee maternal and fetal well-being, including a dramatic increase in glomerular filtration rate, alterations in tubular function, and changes in electrolyte and acid/base handling. Early in gestation, systemic vasodilation, driven by both a change in quantity of and response to various hormones, leads to increased renal blood flow and glomerular filtration rate. Read More

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November 2020