2,435 results match your criteria Respiratory Alkalosis


Mechanisms of acid-base regulation following respiratory alkalosis in red drum (Sciaenops ocellatus).

Comp Biochem Physiol A Mol Integr Physiol 2020 Aug 4:110779. Epub 2020 Aug 4.

Marine Science Institute, University of Texas at Austin, Port Aransas, TX 78373, USA.

Respiratory acidosis and subsequent metabolic compensation are well-studied processes in fish exposed to elevated CO (hypercapnia). Yet, such exposures in the marine environment are invariably accompanied by a return of environmental CO to atmospheric baselines. This understudied phenomenon has the potential to cause a respiratory alkalosis that would necessitate base excretion. Read More

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http://dx.doi.org/10.1016/j.cbpa.2020.110779DOI Listing

Early onset children's Gitelman syndrome with severe hypokalaemia: a case report.

BMC Pediatr 2020 Aug 5;20(1):366. Epub 2020 Aug 5.

Department of Paediatrics, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 88 Changling Road, Xiqing district, Tianjin, 300000, China.

Background: Hypokalaemia is a common condition among paediatric patients, but severe hypokalaemia is rare and can be life-threatening if not treated properly. The causes of hypokalaemia are complex. Finding the root cause is the key. Read More

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http://dx.doi.org/10.1186/s12887-020-02265-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409408PMC

Phosphate metabolism and Respiratory Alkalosis: a forgotten lesson in COVID-19.

Age Ageing 2020 Jul 28. Epub 2020 Jul 28.

Manchester University NHS Foundation Trust.

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http://dx.doi.org/10.1093/ageing/afaa176DOI Listing

A case of Crimean Congo hemorrhagic fever complicated with acute pulmonary embolism.

J Med Virol 2020 Jul 27. Epub 2020 Jul 27.

Department of Infectious Diseases, Faculty of Medicine, Erciyes University, Kayseri, Turkey.

Background: Crimean-Congo hemorrhagic fever (CCHF) is one of the common causes of tick-borne hemorrhagic infections. The study aims to report a case of a female patient with severe CCHF with pulmonary embolism.

Case Report: A 61-year-old woman admitted to the emergency department with complaints of high fever, nausea, and weakness. Read More

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http://dx.doi.org/10.1002/jmv.26358DOI Listing

Cardiogenic Auto-Triggering as a Consequence of Hemoperitoneum.

Chest 2020 Jul 2;158(1):e1-e3. Epub 2020 Jul 2.

Department of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI.

A 70-year-old woman presented with hemorrhagic shock secondary to hemoperitoneum following a paracentesis. On hospital day 3, she developed respiratory alkalosis and increased respiratory rates observed on the ventilator despite no spontaneous inspiratory effort. Converting to pressure support mode uncovered a cardiogenic oscillatory flow that had been auto-triggering the ventilator. Read More

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http://dx.doi.org/10.1016/j.chest.2020.03.023DOI Listing

A Dietary Sugarcane-Derived Polyphenol Mix Reduces the Negative Effects of Cyclic Heat Exposure on Growth Performance, Blood Gas Status, and Meat Quality in Broiler Chickens.

Animals (Basel) 2020 Jul 8;10(7). Epub 2020 Jul 8.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville Melbourne, Victoria 3010, Australia.

Heat stress (HS) compromises growth performance and meat quality of broiler chickens by interrupting lipid and protein metabolism, resulting in increased oxidative damages. The experiment attempted to investigate whether dietary polyphenols (Polygain (POL)) could ameliorate the aforementioned adverse effects of HS on performance and meat quality. One hundred and twenty one day-old-male chicks were allocated to two temperature conditions, thermoneutral (TN) or HS, and fed with either a control diet (CON) or the CON plus four different doses of POL (2, 4, 6 and 10 g/kg). Read More

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http://dx.doi.org/10.3390/ani10071158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401608PMC

Respiratory problems owing to severe metabolic alkalosis in infants presenting with hypertrophic pyloric stenosis.

J Pediatr Surg 2020 Jun 6. Epub 2020 Jun 6.

Department of Paediatric Surgery, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam and Vrije Universiteit Amsterdam, The Netherlands.

Objective: Uncorrected metabolic alkalosis in infantile hypertrophic pyloric stenosis (IHPS) could lead to perioperative apnea. However, the precise incidence of preoperative respiratory problems and the association with metabolic alkalosis are unknown. Therefore, we aimed to determine the incidence of preoperative respiratory problems in IHPS and to assess the association with metabolic alkalosis. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2020.05.041DOI Listing

Clinical and Genotypical Features of False-Negative Patients in 26 Years of Cystic Fibrosis Neonatal Screening in Tuscany, Italy.

Diagnostics (Basel) 2020 Jul 1;10(7). Epub 2020 Jul 1.

Department of Pediatric, Meyer Children's Hospital, University of Florence, Viale Pieraccini 24, 50139 Florence, Italy.

Cystic fibrosis (CF) is a life-threatening and common genetic disorder. Cystic fibrosis newborn screening (CF NBS) has been implemented in many countries over the last 30 years, becoming a widely accepted public health strategy in economically developed countries. False-negative (FN) cases can occur after CF NBS, with the number depending on the method. Read More

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http://dx.doi.org/10.3390/diagnostics10070446DOI Listing

Comparative Analysis of Clinical and Biochemical Profile of Exertional Heat Related Illness Among Cadets in a Military Training Centre in South India: A Single Centre Experience.

J Assoc Physicians India 2020 Apr;68(4):29-31

Senior Advisor Medicine and Oncology, Command Hospital, Bengaluru, Karnataka.

Background: Heat-related illnesses includes a range of manifestation starting from minor illness like heat rashes/ heat cramps to more complicated illness like heat exhaustion and the most severe heat stroke. Often derangements in biochemical parameters including metabolic acidosis, respiratory alkalosis, electrolytes, transminitis and renal dysfunction are noticed in patients with heat stroke. Objective: The present study was an attempt to compare the clinical and changes in biochemical parameters in exertional heat exhaustion and heat stroke patients among cadets from a military training centre admitted to an Armed forces hospital in South India. Read More

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Acid-base disturbances in dehydrated patients with cystic fibrosis : four case reports with review of literature.

Acta Gastroenterol Belg 2020 Apr-Jun;83(2):315-318

Cystic Fibrosis Centre, Ghent University Hospital.

Most episodes of vomiting, reduced intake and diarrhoea in children can be evaluated and treated without additional tests. However, when the degree of clinical dehydration is not in line with the patient's medical history, other diagnoses should be suspected. In the presence of a hyponatraemic hypochloraemic metabolic alkalosis, cystic fibrosis (CF) should be included in the differential diagnosis, especially if there is failure to thrive even in the absence of respiratory symptoms. Read More

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A Case of Pulmonary Cement Embolism Managed through Symptomatic Treatment.

Case Rep Crit Care 2020 4;2020:2425973. Epub 2020 Jun 4.

Advent Health, Orlando, FL, USA.

Objective: This case describes symptomatic pulmonary cement embolism as a rare postvertebroplasty complication and highlights its critical yet ill-defined management.

Background: Pulmonary cement embolism (PCE) is a feared complication of vertebroplasty in the treatment of vertebral fractures. While the majority of PCEs are asymptomatic, symptomatic PCEs often present with chest pain, tachycardia, signs of severe respiratory distress, and death. Read More

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http://dx.doi.org/10.1155/2020/2425973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293736PMC

Circulatory Failure among Hospitalizations for Heatstroke in the United States.

Medicines (Basel) 2020 Jun 14;7(6). Epub 2020 Jun 14.

Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok 10400, Thailand.

This study aimed to assess the risk factors and the association of circulatory failure with treatments, complications, outcomes, and resource utilization in hospitalized patients for heatstroke in the United States. Hospitalized patients with a principal diagnosis of heatstroke were identified in the National Inpatient Sample dataset from the years 2003 to 2014. Circulatory failure, defined as any type of shock or hypotension, was identified using hospital diagnosis codes. Read More

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http://dx.doi.org/10.3390/medicines7060032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344500PMC

Biotinidase Deficiency With Suspected Sotos Syndrome: A Rare Entity.

Cureus 2020 May 7;12(5):e8000. Epub 2020 May 7.

Pediatrics, Abbasi Shaheed Hospital, Karachi, PAK.

Biotinidase deficiency (BTD) is a rare yet treatable metabolic autosomal recessive (AR) disorder in which the body is unable to recycle the vitamin biotin. Early diagnosis and treatment can be life-saving, but some symptoms of the disease are irreversible, and the condition can even prove to be fatal if not correctly diagnosed and managed. Here we present a case of a six-month-old child who presented with cough, fever, and difficulty in breathing. Read More

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http://dx.doi.org/10.7759/cureus.8000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274502PMC

Severe Respiratory Alkalosis in Acute Ischemic Stroke: A Rare Presentation.

Cureus 2020 Apr 20;12(4):e7747. Epub 2020 Apr 20.

Internal Medicine, The University of Texas Health Science Center/Christus Good Shepherd Medical Center, Longview, USA.

Respiratory alkalosis is a rare but severe complication of acute ischemic stroke (AIS). In ischemic stroke, respiratory alkalosis results from hyperventilation due to the effect of stroke on the respiratory center. We report a case of a young male who presented with acute encephalopathy. Read More

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http://dx.doi.org/10.7759/cureus.7747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241218PMC

[Respiratory alkalosis complicated in percutaneous endoscopic lumbar discectomy under local anesthesia:a case report].

Zhongguo Gu Shang 2020 05;33(5):476-8

The Second Department of Orthopaedics, People's Hospital of Gansu Province, Lanzhou 730000, Gansu, China.

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http://dx.doi.org/10.12200/j.issn.1003-0034.2020.05.017DOI Listing

Intralipid and haemodialysis in caffeine overdose.

BMJ Case Rep 2020 May 14;13(5). Epub 2020 May 14.

Critical Care, Queen Elizabeth Woolwich, London, UK.

A 26-year-old woman presented after an intentional ingestion of 20 g of caffeine. She suffered a profound respiratory alkalosis with metabolic acidosis, hypokalaemia and sustained polymorphic ventricular tachycardia. She was treated with intravenous intralipid and haemodialysis, and her arrhythmia was controlled using magnesium sulphate. Read More

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http://dx.doi.org/10.1136/bcr-2020-234256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232395PMC

Idiopathic Carpal Spasm (Trousseau's Sign) After Intraoperative Arm Tourniquet Inflation in an Intubated Patient.

Cureus 2020 Apr 4;12(4):e7543. Epub 2020 Apr 4.

Plastic Surgery, St. James's Hospital, Dublin, IRL.

We present a case of a 38-year-old male who sustained a laceration from a knife to the volar aspect of his left index and middle fingers. He had clinical injury to his flexor digitorum profundus tendons to both digits. He underwent operative exploration and repair of the tendons under general anaesthetic. Read More

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http://dx.doi.org/10.7759/cureus.7543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198088PMC

Study of Acid-Base Disorders and Biochemical Findings of Patients in a Tertiary Care Hospital: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2019 Nov-Dec;57(220):432-436

Department of Biochemistry, Nobel Medical College Teaching Hospital, Biratnagar, Nepal.

Introduction: Acid base disorder is a condition characterized by alteration in blood pH by the imbalance between the components of blood leading to a life threatening situation. The main aim of this study was to find the prevalence of acid-base disorders and biochemical findings of such disorders in patients in a tertairy care hospital.

Methods: This descriptive cross-sectional study was conducted in Nobel Medical College Teaching Hospital from 1st September, 2018 to 31st August, 2019. Read More

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Respiratory Alkalosis in Neurodegenerative Disorder.

Indian J Pediatr 2020 Apr 24. Epub 2020 Apr 24.

Department of Pediatrics, All India Institute of Medical Sciences, Bhubaneswar, Odisha, 751019, India.

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http://dx.doi.org/10.1007/s12098-020-03288-xDOI Listing

The Effect of Heat Stress on Respiratory Alkalosis and Insulin Sensitivity in Cinnamon Supplemented Pigs.

Animals (Basel) 2020 Apr 15;10(4). Epub 2020 Apr 15.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Melbourne, VIC 3010, Australia.

With increases in the frequency, intensity and duration of heat waves forecast plus expansion of tropical agriculture, heat stress (HS) is both a current and an emerging problem. As cinnamon has been shown to increase insulin sensitivity, which is part of the adaptive response to HS, the aim of this experiment was to determine if cinnamon could improve insulin sensitivity and ameliorate HS in grower pigs. In a 2 × 2 factorial design, 36 female Large White × Landrace pigs were fed control (0%) vs. Read More

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http://dx.doi.org/10.3390/ani10040690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222789PMC

Fentanyl-induced block of hERG channels is exacerbated by hypoxia, hypokalemia, alkalosis, and the presence of hERG1b.

Mol Pharmacol 2020 Apr 22. Epub 2020 Apr 22.

Queen's University

Human ether-a-go-go-related gene () encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel (I) important for repolarization of cardiac action potentials. Drug-induced disruption of hERG channel function is a main cause of acquired long QT syndrome (LQTS), which can lead to ventricular arrhythmias and sudden death. Illicit fentanyl use is associated with sudden death. Read More

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http://dx.doi.org/10.1124/mol.119.119271DOI Listing

Perioperative apnea in infants with hypertrophic pyloric stenosis: A systematic review.

Paediatr Anaesth 2020 Apr 16. Epub 2020 Apr 16.

Department of Paediatric Surgery, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands.

Background: Infantile hypertrophic pyloric stenosis (IHPS) leads to excessive vomiting and metabolic alkalosis, which may subsequently cause apnea. Although it is generally assumed that metabolic derangements should be corrected prior to surgery to prevent apnea, the exact incidence of perioperative apneas in infants with IHPS and the association with metabolic alkalosis are unknown. We performed this systematic review to assess the incidence of apnea in infants with IHPS and to verify the possible association between apnea and metabolic alkalosis. Read More

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http://dx.doi.org/10.1111/pan.13879DOI Listing

Acetazolamide Causes Worsening Acidosis in Uncompensated COPD Exacerbations: Increased Awareness Needed for Patient Safety.

Authors:
Jennifer L Cole

J Emerg Med 2020 Jun 30;58(6):953-958. Epub 2020 Mar 30.

Veterans Healthcare System of the Ozarks, Fayetteville, Arkansas.

Background: Acetazolamide has been studied extensively in post-hypercapnic alkalosis as a tool to facilitate ventilator weaning in chronic obstructive pulmonary disease (COPD). It has also been utilized to facilitate respiratory drive in nonmechanically ventilated patients with COPD. Although this is generally a forgiving intervention, providers must carefully select patients for this medication, as it can cause severe acidosis and deterioration of clinical status in severe COPD cases. Read More

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http://dx.doi.org/10.1016/j.jemermed.2020.01.019DOI Listing

Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study.

BMJ 2020 03 26;368:m1091. Epub 2020 Mar 26.

Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

Objective: To delineate the clinical characteristics of patients with coronavirus disease 2019 (covid-19) who died.

Design: Retrospective case series.

Setting: Tongji Hospital in Wuhan, China. Read More

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http://dx.doi.org/10.1136/bmj.m1091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190011PMC

Spironolactone-furosemide combination therapy and acid-base disorders in liver cirrhosis patients
.

Int J Clin Pharmacol Ther 2020 May;58(5):261-267

Objective: Respiratory alkalosis (RA) and dilutional hyperchloremic acidosis (DHA) are the most common acid-base balance (ABB) disorders in patients with liver cirrhosis. The aims of this study were to clarify whether RA develops in relation to DHA via respiratory compensation of metabolic acidosis and whether spironolactone in combination with low-dose furosemide - diuretics known to ameliorate DHA - positively affects RA in liver cirrhosis patients.

Materials And Methods: 59 patients with advanced cirrhosis were divided into two groups. Read More

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http://dx.doi.org/10.5414/CP203624DOI Listing

Unchanged cerebrovascular CO reactivity and hypercapnic ventilatory response during strict head-down tilt bed rest in a mild hypercapnic environment.

J Physiol 2020 Jun 2;598(12):2491-2505. Epub 2020 May 2.

NASA Johnson Space Center, Houston, TX, USA.

Key Points: Carbon dioxide levels are mildly elevated on the International Space Station and it is unknown whether this chronic exposure causes physiological changes to astronauts. We combined ∼4 mmHg ambient with the strict head-down tilt bed rest model of spaceflight and this led to the development of optic disc oedema in one-half of the subjects. We demonstrate no change in arterialized , cerebrovascular reactivity to CO or the hypercapnic ventilatory response. Read More

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http://dx.doi.org/10.1113/JP279383DOI Listing

Effects of respiratory rate on venous-to-arterial CO tension difference in septic shock patients undergoing volume mechanical ventilation.

Eur J Med Res 2020 Mar 17;25(1). Epub 2020 Mar 17.

Department of Critical Care Medicine, The 901st Hospital of the Joint Logistics Support Force of PLA, No. 424 Changjiang West Road, Hefei, 230000, Anhui, China.

Background: To explore the effects of the respiratory rate (RR) on the venous-to-arterial CO tension difference (gapCO) in septic shock patients undergoing volume mechanical ventilation.

Methods: Adult patients with septic shock underwent volume mechanical ventilation between October 2015 and October 2016. RR was started at 10 breaths/min, and 2 breaths/min were added every 60 min until 16 breaths/min was reached. Read More

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http://dx.doi.org/10.1186/s40001-020-00402-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076974PMC

Endogenous brain-sparing responses in brain pH and PO in a rodent model of birth asphyxia.

Acta Physiol (Oxf) 2020 Jul 3;229(3):e13467. Epub 2020 Apr 3.

Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences, University of Helsinki, Helsinki, Finland.

Aim: To study brain-sparing physiological responses in a rodent model of birth asphyxia which reproduces the asphyxia-defining systemic hypoxia and hypercapnia.

Methods: Steady or intermittent asphyxia was induced for 15-45 minutes in anaesthetized 6- and 11-days old rats and neonatal guinea pigs using gases containing 5% or 9% O plus 20% CO (in N ). Hypoxia and hypercapnia were induced with low O and high CO respectively. Read More

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http://dx.doi.org/10.1111/apha.13467DOI Listing

Role of electrolyte abnormalities and unmeasured anions in the metabolic acid-base abnormalities in dogs with parvoviral enteritis.

J Vet Intern Med 2020 Mar 4;34(2):857-866. Epub 2020 Mar 4.

Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Pretoria, South Africa.

Background: The strong ion model (SIM) is an alternative paradigm in the characterization of acid-base disturbances particularly in complex disorders.

Hypothesis/objectives: To compare the acid-base changes in dogs with parvoviral enteritis (PE) using the Henderson-Hasselbalch (HH) approach, with 2 strong ion approaches.

Animals: Forty-four dogs with PE, and 16 age-matched control dogs. Read More

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http://dx.doi.org/10.1111/jvim.15749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096617PMC

Sodium Fate after Sodium Bicarbonate Infusion: Influence of Altered Acid-Base Status.

Am J Nephrol 2020 18;51(3):182-191. Epub 2020 Feb 18.

Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA,

Background: We have previously investigated the fate of administered bicarbonate infused as a hypertonic solution in animals with each of the 4 chronic acid-base disorders. Those studies did not address the fate of sodium, the coadministered cation.

Methods: We examined baseline total body water (TBW), Na+ space, HCO3- space, and urinary sodium and bicarbonate excretion after acute hypertonic NaHCO3 infusion (1-N solution, 5 mmol/kg body weight) in dogs with each of the 4 chronic acid-base disorders. Read More

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http://dx.doi.org/10.1159/000506274DOI Listing
February 2020

Renovascular hypertension elevates pulmonary ventilation in rats by carotid body-dependent mechanisms.

Am J Physiol Regul Integr Comp Physiol 2020 04 5;318(4):R730-R742. Epub 2020 Feb 5.

Department of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.

The two kidney-one clip (2K1C) renovascular hypertension depends on the renin-angiotensin system and sympathetic overactivity. The maintenance of 2K1C hypertension also depends on inputs from the carotid bodies (CB), which when activated stimulate the respiratory activity. In the present study, we investigated the importance of CB afferent activity for the ventilatory responses in 2K1C hypertensive rats and for phrenic and hypoglossal activities in in situ preparations of normotensive rats treated with angiotensin II. Read More

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http://dx.doi.org/10.1152/ajpregu.00134.2019DOI Listing

A Delphi Analysis to Reach Consensus on Preoperative Care in Infants with Hypertrophic Pyloric Stenosis.

Eur J Pediatr Surg 2020 Jan 20. Epub 2020 Jan 20.

Department of Pediatric Surgery, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam & Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Introduction:  Infantile hypertrophic pyloric stenosis (IHPS) is a common gastrointestinal condition that can lead to metabolic alkalosis and, if uncorrected, to respiratory complications. A standardized approach to correct metabolic derangements and dehydration may reduce time until pyloromyotomy while preventing potential respiratory complications. Such an evidence-based policy regarding preoperative care is absent. Read More

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http://dx.doi.org/10.1055/s-0039-3401987DOI Listing
January 2020

Derangement of PaCO requires physician attention in acute carbon monoxide poisoning.

Hum Exp Toxicol 2020 May 13;39(5):642-652. Epub 2020 Jan 13.

Department of Emergency Medicine, Chonnam National University Medical School, Gwangju, South Korea.

The objective was to describe the prevalence of derangement of the partial pressure of arterial carbon dioxide (PaCO) and to determine the association between PaCO and adverse cardiovascular events (ACVEs) in carbon monoxide (CO)-poisoned patients. Additionally, we evaluated whether the derangement of PaCO was simply secondary to metabolic changes. This retrospective study included 194 self-breathing patients after CO poisoning with an indication for hyperbaric oxygen therapy and available arterial blood gas analysis at presentation and 6 h later. Read More

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http://dx.doi.org/10.1177/0960327119898720DOI Listing

Can Venous Blood Gas Be Used as an Alternative to Arterial Blood Gas in Intubated Patients at Admission to the Emergency Department? A Retrospective Study.

Open Access Emerg Med 2019 23;11:305-312. Epub 2019 Dec 23.

Department of Emergency Medicine, Medical University of Vienna, Vienna A-1090, Austria.

Objective: Blood gas analysis plays an important role in both diagnosis and subsequent treatment of critically ill patients in the emergency department and the ICU. Historically, arterial blood is predominantly used for blood gas analysis. The puncture is painful and complications may occur. Read More

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http://dx.doi.org/10.2147/OAEM.S228420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934126PMC
December 2019

Community-acquired pneumonia complicated by rhabdomyolysis: A clinical analysis of 11 cases.

Authors:
Bo Zhao Rui Zheng

World J Clin Cases 2019 Dec;7(24):4218-4225

Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.

Background: In clinical practice, community-acquired pneumonia (CAP) can be complicated by rhabdomyolysis (RM), and RM symptoms are mild and easily missed during diagnosis. Moreover, available data on RM induced by CAP are mainly from case reports. Due to the relatively low incidence of CAP-induced RM, more systematic studies are required to understand the characteristics of CAP-induced RM to improve its diagnosis and treatment. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i24.4218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940340PMC
December 2019

Cerebral metabolism, oxidation and inflammation in severe passive hyperthermia with and without respiratory alkalosis.

J Physiol 2020 Mar 11;598(5):943-954. Epub 2020 Feb 11.

Faculty of Health and Social Development, Center for Heart Lung and Vascular Health University of British Columbia, Kelowna, British Columbia, Canada.

Key Points: It was unknown whether respiratory alkalosis impacts the global cerebral metabolic response as well as the cerebral pro-oxidation and inflammatory response in passive hyperthermia. This study demonstrated that the cerebral metabolic rate was increased by ∼20% with passive hyperthermia of up to +2°C oesophageal temperature, and this response was unaffected by respiratory alkalosis. Additionally, the increase in cerebral metabolism did not significantly impact the net cerebral release of oxidative and inflammatory markers. Read More

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http://dx.doi.org/10.1113/JP278889DOI Listing

Use of sacubitril/valsartan in Marfan syndrome-related cardiomyopathy: The first case report.

Medicine (Baltimore) 2019 Nov;98(47):e17978

Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy.

Rationale: Marfan syndrome is a rare cause of heart failure due to primary or secondary cardiomyopathy. Recently, sacubitril/valsartan-an angiotensin receptor blocker-neprilysin inhibitor-has been added in clinical practice as a standard therapy for heart failure. To our knowledge, there are no data on sacubitril/valsartan's effects on cardiovascular outcomes in patients with Marfan syndrome. Read More

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http://dx.doi.org/10.1097/MD.0000000000017978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882602PMC
November 2019

Don't Take It 'Lytely': A Case of Acute Tetany.

Cureus 2019 Oct 5;11(10):e5845. Epub 2019 Oct 5.

Internal Medicine, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, USA.

The most common causes of tetany are hypocalcemia, hypomagnesemia, hypokalemia, and alkalosis. Most case reports of tetany in the literature include some combination of the above metabolic derangements leading to non-life-threatening symptoms. We present a unique case of severe life-threatening tetany in a 38-year-old female with a history of Crohn's disease. Read More

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http://dx.doi.org/10.7759/cureus.5845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830852PMC
October 2019

An 82-Year-Old Man With Sleep-Onset Insomnia, Breathing Arrest, and Heart Failure.

Chest 2019 11;156(5):e95-e98

Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany; Interdisciplinary Centre for Sleep and Ventilatory Medicine, Jena University Hospital, Jena, Germany; Research Programme "Else Kröner-Forschungskolleg AntiAge", Jena University Hospital, Jena, Germany. Electronic address:

Case Presentation: An 82-year-old man presented with 6 months of difficulties of falling asleep. He described a feeling of fading breath culminating in breathing arrest when he becomes drowsy. These recurrent events prevented him from falling asleep. Read More

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http://dx.doi.org/10.1016/j.chest.2019.05.044DOI Listing
November 2019

[Interpretation of acid-base disorders].

Med Klin Intensivmed Notfmed 2019 Nov 22;114(8):765-776. Epub 2019 Oct 22.

Medizinische Abteilung mit Pneumologie, Wilhelminenspital, Wien, Österreich.

Keeping blood pH levels stable within narrow limits is prerequisite for maintaining normal body function. Disruptions of this equilibrium can occur for a variety of reasons and may result in life-threatening conditions. Therefore, the identification and the interpretation of acid-base disorders are of great importance in emergency medicine. Read More

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http://dx.doi.org/10.1007/s00063-019-00621-xDOI Listing
November 2019

Influence of methazolamide on the human control of breathing: A comparison to acetazolamide.

Exp Physiol 2020 Feb 26;105(2):293-301. Epub 2019 Oct 26.

Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Science, University of British Columbia, Kelowna, BC, Canada.

New Findings: What is the central question of this study? Acetazolamide and methazolamide both reduce hypoxic pulmonary vasoconstriction equally, but methazolamide does not impair skeletal muscle function. The effect of methazolamide on respiratory control in humans is not yet known. What is the main finding and its importance? Similar to acetazolamide after chronic oral administration, methazolamide causes a metabolic acidosis and shifts the ventilatory CO response curve leftwards without reducing O sensitivity. Read More

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http://dx.doi.org/10.1113/EP088058DOI Listing
February 2020
2 Reads

Refractory Central Neurogenic Hyperventilation: A Novel Approach Utilizing Mechanical Dead Space.

Front Neurol 2019 4;10:937. Epub 2019 Sep 4.

Department of Neurology, University of California, Irvine, Irvine, CA, United States.

This report describes the successful management of a case of central neurogenic hyperventilation (CNH) refractory to high dose sedation by increasing the mechanical dead space. A 46-year-old male presented with a history of multiple neurological symptoms. Following an extensive evaluation, he was diagnosed with primary diffuse CNS lymphoma and started on high dose steroids. Read More

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http://dx.doi.org/10.3389/fneur.2019.00937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737039PMC
September 2019
2 Reads

Growth Performance and Characterization of Meat Quality of Broiler Chickens Supplemented with Betaine and Antioxidants under Cyclic Heat Stress.

Antioxidants (Basel) 2019 Aug 22;8(9). Epub 2019 Aug 22.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.

Heat stress (HS) causes oxidative stress, which compromises broiler performance and meat quality. The aim of this study was to determine whether dietary antioxidants could be used as an amelioration strategy. Seventy-two day-old-male Ross-308 chicks were exposed to either thermoneutral or cyclical heat stress conditions. Read More

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http://dx.doi.org/10.3390/antiox8090336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769705PMC
August 2019
2 Reads

Survival and Neurologic Recovery After Prompt Diagnosis and Aggressive Management of Severe Idiopathic Hyperammonemic Encephalopathy in a Patient with Acute Myeloid Leukemia.

J Pediatr Hematol Oncol 2020 Aug;42(6):e452-e455

Department of Pediatrics, Texas Children's Cancer and Hematology Center.

A case of a 19-year-old female with low-risk acute myeloid leukemia is presented who was diagnosed with idiopathic hyperammonemic encephalopathy following the development of abrupt neurologic decline, respiratory alkalosis, and elevated plasma ammonia levels of unknown etiology. Delayed symptom recognition of this exceedingly rare condition contributes to the often fatal outcomes of idiopathic hyperammonemic encephalopathy. As illustrated by this case, prompt diagnosis and utilization of a variety of ammonia-modulating treatment modalities can result in remarkable clinical recovery. Read More

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http://Insights.ovid.com/crossref?an=00043426-900000000-9748
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http://dx.doi.org/10.1097/MPH.0000000000001579DOI Listing
August 2020
3 Reads

A case of hyperventilation leading to apnea and desaturation in PACU.

BMC Anesthesiol 2019 08 14;19(1):152. Epub 2019 Aug 14.

Department of Anaesthesiology and Critical Care, B. P. Koirala Institute of Health Sciences, Dharan, Koshi, Nepal.

Background: Respiratory adverse events are not uncommon in the post-anesthesia care unit (PACU) following general anesthesia. In this regard, hyperventilation leading to apnea and desaturation is a rare entity. Here we have reported a case of a 15-year-old girl who, following an uneventful general anesthesia, developed severe hyperventilation leading to apnea and desaturation in the PACU. Read More

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http://dx.doi.org/10.1186/s12871-019-0827-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694688PMC
August 2019
6 Reads

A case of central neurogenic hyperventilation without tachypnoea.

Respirol Case Rep 2019 Oct 16;7(7):e00462. Epub 2019 Jul 16.

Department of Pulmonary Medicine Tokyo Saiseikai Central Hospital Tokyo Japan.

Central neurogenic hyperventilation (CNH) is a rare condition, with 37 cases reported in the literature to date. The underlying mechanisms remain unclear. Primary central nervous system lymphoma (PCNSL) is the most common cause of CNH, with 17 cases reported so far. Read More

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http://dx.doi.org/10.1002/rcr2.462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635121PMC
October 2019
3 Reads

Lessons of the month 2: A forgotten cause of transient T-wave inversion.

Clin Med (Lond) 2019 07;19(4):334-335

Royal Hampshire County Hospital, Winchester, UK.

A 19-year-old patient presented with severe chest pain, which is not typical for cardiac angina. However, his smoking history and the strong family history of ischaemic heart disease coupled with evidence of progressive T-wave changes on his electrocardiogram (ECG) caused dilemma in deciding further management. His blood tests were normal apart from hypophosphataemia, and he had two negative troponin results. Read More

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http://dx.doi.org/10.7861/clinmedicine.19-4-334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752258PMC
July 2019
3 Reads