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    7393 results match your criteria Respiratory Acidosis

    1 OF 148

    Thoracoscopic repair of congenital diaphragmatic hernia, review of the results.
    Minerva Pediatr 2017 Nov 21. Epub 2017 Nov 21.
    Department of Pediatric Surgery, Hospital de Braga, Braga, Portugal.
    Congenital diaphragmatic hernia (CDH) remains one of the major challenges in neonatal surgery. Survival rate has increased in the last decades mainly due to perinatal care and surgical technique improvements. Classically, a laparotomy has been performed after cardiovascular and respiratory stabilization. Read More

    Determinants and Outcome of Metabolic Acidosis in Diarrheal Children Under 5 Years of Age in an Urban Critical Care Ward in Bangladesh.
    Glob Pediatr Health 2017 7;4:2333794X17740223. Epub 2017 Nov 7.
    International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
    We evaluated the independent determinants and outcome of metabolic acidosis in diarrheal children. Children under 5 years of age admitted with diarrhea and severe respiratory distress in the critical care ward at Dhaka Hospital of icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh) from April 2010 to April 2014 who had their reports of arterial blood gas analyses were enrolled in the study. We compared clinical and laboratory characteristics between the study children with (cases = 74) and without metabolic acidosis (controls = 65). Read More

    Incidence and Consequences of Near-Drowning-Related Pneumonia-A Descriptive Series from Martinique, French West Indies.
    Int J Environ Res Public Health 2017 Nov 17;14(11). Epub 2017 Nov 17.
    Intensive Care Unit, University Hospital of Martinique, Fort-de-France, 97261 Martinique, France.
    Drowning represents one major cause of accidental death. Near-drowning patients are exposed to aspiration that may result in pneumonia with life-threatening consequences. We designed this descriptive study to investigate the frequency, nature, and consequences of post-drowning pneumonia. Read More

    Metabolic effects of Carbon Dioxide (CO2) insufflation during laparoscopic surgery: changes in pH, arterial partial Pressure of Carbon Dioxide (PaCo2) and End Tidal Carbon Dioxide (EtCO2).
    Cent Afr J Med 2015 Sep-Dec;61(9-12):61-5
    Background: Acid base alterations occur during laparoscopy with carbon dioxide insufflation. The purpose of this study was to investigate the effects of low tidal volume ventilation on acid base status during pneumoperitonium.

    Materials And Methods: 30 patients undergoing laparoscopic surgery under General Anaesthesia were ventilated with tidal volume of 6 ml/kg and respiratory rate of 12 breaths/minute. Read More

    Shifting Risks and Conflicting Outcomes-ECMO for Neonates with Congenital Diaphragmatic Hernia in the Modern Era.
    J Pediatr 2017 Nov;190:163-168.e4
    Department of Pediatrics, University of Washington, Seattle, WA.
    Objectives: To update previously described trends for neonates with congenital diaphragmatic hernia (CDH) receiving ECMO with changes in recommendations for care, and to determine how recent advancements in respiratory care have affected this patient population.

    Study Design: This study is a retrospective review of more than 2500 neonates with CDH who received ECMO listed in the Extracorporeal Life Support Organization (ELSO) registry. Cochran-Armitage and multivariate regression analyses were used to analyze changes in the patient population over time and in mortality-related risk factors. Read More

    Intensive care in severe malaria: Report from the task force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine.
    J Crit Care 2017 Nov 8. Epub 2017 Nov 8.
    Department of Critical Care Medicine, Bombay Hospital Institute of Medical Sciences, Mumbai, India. Electronic address:
    Severe malaria is common in tropical countries in Africa, Asia, Oceania and South and Central America. It may also occur in travelers returning from endemic areas. Plasmodium falciparum accounts for most cases, although P vivax is increasingly found to cause severe malaria in Asia. Read More

    Acute Systemic Complications of Convulsive Status Epilepticus-A Systematic Review.
    Crit Care Med 2017 Nov 2. Epub 2017 Nov 2.
    1Clinic for Intensive Care Medicine, University Hospital Basel, Basel, Switzerland. 2Division of Clinical Neurophysiology, Department of Neurology, University Hospital Basel, Basel, Switzerland. 3University of Basel, Basel, Switzerland. 4Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, MD.
    Objectives: Status epilepticus is a neurologic emergency with high morbidity and mortality requiring neurointensive care and treatment of systemic complications. This systematic review compiles the current literature on acute systemic complications of generalized convulsive status epilepticus in adults and their immediate clinical impact along with recommendations for optimal neurointensive care.

    Data Sources: We searched PubMed, Medline, Embase, and the Cochrane library for articles published between 1960 and 2016 and reporting on systemic complications of convulsive status epilepticus. Read More

    Pulseless electrical activity during general anesthesia induction in patients with amyotrophic lateral sclerosis.
    J Dent Anesth Pain Med 2017 Sep 25;17(3):235-240. Epub 2017 Sep 25.
    Department of Anesthesiology, School of Dentistry, Dankook University, Cheonan, Korea.
    Pulseless electrical activity (PEA) is a clinical condition characterized by unresponsiveness and lack of palpable pulse in the presence of organized cardiac electrical activity and is caused by a profound cardiovascular insult (e.g., severe prolonged hypoxia or acidosis, extreme hypovolemia, or flow-restricting pulmonary embolus). Read More

    Quantitative relationships among plasma lactate, inorganic phosphorus, albumin, unmeasured anions and the anion gap in lactic acidosis.
    J Crit Care 2017 Oct 13;44:101-110. Epub 2017 Oct 13.
    Department of Anesthesiology, Kobe University Hospital, Kobe City, Hyogo 650-0017, Japan.
    Background: Quantitative relationships among plasma [Lactate], [Pi], [Albumin], unmeasured anions ([UA]) and the anion gap (AGK) in lactic acidosis (LA) are not well defined.

    Methods: A mathematical model featuring compensatory potassium and chloride shifts and respiratory changes in LA demonstrated: (1) AGK=[Lactate]+Zp×[Pi]+2.4×[Albumin]+constant1+e, where Zp is a function of pH, and e reflects unmeasured anions and cations plus pH-related variations. Read More

    A novel de novo dominant mutation in ISCU associated with mitochondrial myopathy.
    J Med Genet 2017 Oct 27. Epub 2017 Oct 27.
    Molecular Neurogenetics Unit, Foundation IRCCS Neurological Institute Besta, Milan, Italy.
    Background: Hereditary myopathy with lactic acidosis and myopathy with deficiency of succinate dehydrogenase and aconitase are variants of a recessive disorder characterised by childhood-onset early fatigue, dyspnoea and palpitations on trivial exercise. The disease is non-progressive, but life-threatening episodes of widespread weakness, metabolic acidosis and rhabdomyolysis may occur. So far, this disease has been molecularly defined only in Swedish patients, all homozygous for a deep intronic splicing affecting mutation in ISCU encoding a scaffold protein for the assembly of iron-sulfur (Fe-S) clusters. Read More

    Effects of lung protective mechanical ventilation associated with permissive respiratory acidosis on regional extra-pulmonary blood flow in experimental ARDS.
    BMC Anesthesiol 2017 Oct 27;17(1):149. Epub 2017 Oct 27.
    Department of Anesthesia and Intensive Care Medicine, University Hospital of Bonn, Bonn, Germany.
    Background: Lung protective mechanical ventilation with limited peak inspiratory pressure has been shown to affect cardiac output in patients with ARDS. However, little is known about the impact of lung protective mechanical ventilation on regional perfusion, especially when associated with moderate permissive respiratory acidosis. We hypothesized that lung protective mechanical ventilation with limited peak inspiratory pressure and moderate respiratory acidosis results in an increased cardiac output but unequal distribution of blood flow to the different organs of pigs with oleic-acid induced ARDS. Read More

    Factors relating caesarean section to persistent pulmonary hypertension of the newborn.
    World J Pediatr 2017 Dec 20;13(6):517-527. Epub 2017 Oct 20.
    Department of Neonatology, Children Hospital of Fudan University, Shanghai, 201102, China.
    Background: Several studies have clearly demonstrated a significantly higher incidence of persistent pulmonary hypertension of the newborn (PPHN) in neonates delivered by caesarean section (CS) compared to those delivered vaginally. The pathophysiological factors underlying the link between CS and PPHN are still poorly understood. In this review, we describe the mechanisms that could explain the association between CS delivery and subsequent PPHN, as well as potential preventive measures. Read More

    Acid-base regulation and sensing: Accelerators and brakes in metabolic regulation of cerebrovascular tone.
    J Cereb Blood Flow Metab 2017 Jan 1:271678X17733868. Epub 2017 Jan 1.
    Department of Biomedicine, Aarhus University, Aarhus, Denmark.
    Metabolic regulation of cerebrovascular tone directs blood flow to areas of increased neuronal activity and during disease states partially compensates for insufficient perfusion by enhancing blood flow in collateral blood vessels. Acid-base disturbances frequently occur as result of enhanced metabolism or insufficient blood supply, but despite definitive evidence that acid-base disturbances alter arterial tone, effects of individual acid-base equivalents and the underlying signaling mechanisms are still being debated. H(+) is an important intra- and extracellular messenger that modifies cerebrovascular tone. Read More

    Defective mitochondrial rRNA methyltransferase MRM2 causes MELAS-like clinical syndrome.
    Hum Mol Genet 2017 Nov;26(21):4257-4266
    Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK.
    Defects in nuclear-encoded proteins of the mitochondrial translation machinery cause early-onset and tissue-specific deficiency of one or more OXPHOS complexes. Here, we report a 7-year-old Italian boy with childhood-onset rapidly progressive encephalomyopathy and stroke-like episodes. Multiple OXPHOS defects and decreased mtDNA copy number (40%) were detected in muscle homogenate. Read More

    Acute mitochondrial myopathy with respiratory insufficiency and motor axonal polyneuropathy.
    Int J Neurosci 2017 Oct 16:1-6. Epub 2017 Oct 16.
    d Department of Neurology , Tongren Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China.
    Background: Mitochondrial myopathies (MMs) are mainly presented with chronic muscle weakness and accompanied with other syndromes. MM with acute respiratory insufficiency is rare.

    Aims: To reveal the clinical, pathological and molecular characteristics of a life-threatening MM. Read More

    How important is the CO2 chemoreflex for the control of breathing? Environmental and evolutionary considerations.
    Comp Biochem Physiol A Mol Integr Physiol 2018 Jan 29;215:6-19. Epub 2017 Sep 29.
    University of Missouri, Columbia, United States. Electronic address:
    Haldane and Priestley (1905) discovered that the ventilatory control system is highly sensitive to CO2. This "CO2 chemoreflex" has been interpreted to dominate control of resting arterial PCO2/pH (PaCO2/pHa) by monitoring PaCO2/pHa and altering ventilation through negative feedback. However, PaCO2/pHa varies little in mammals as ventilation tightly couples to metabolic demands, which may minimize chemoreflex control of PaCO2. Read More

    Pulmonary hemodynamics and alveolar oxygenation in healthy dogs anesthetized with propofol or isoflurane during one-lung ventilation in a closed-thoracic experimental model.
    Am J Vet Res 2017 Oct;78(10):1117-1125
    OBJECTIVE To assess pulmonary hemodynamics and alveolar oxygenation in dogs anesthetized with propofol or isoflurane during one-lung ventilation (OLV) in a closed-thoracic experimental model. ANIMALS 6 healthy Beagles. PROCEDURES Dogs were anesthetized with each of 3 protocols (constant rate IV infusion of propofol [0. Read More

    Biallelic C1QBP Mutations Cause Severe Neonatal-, Childhood-, or Later-Onset Cardiomyopathy Associated with Combined Respiratory-Chain Deficiencies.
    Am J Hum Genet 2017 Oct 21;101(4):525-538. Epub 2017 Sep 21.
    Institute of Human Genetics, Technische Universität München, 81675 Munich, Germany; Institute of Human Genetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany. Electronic address:
    Complement component 1 Q subcomponent-binding protein (C1QBP; also known as p32) is a multi-compartmental protein whose precise function remains unknown. It is an evolutionary conserved multifunctional protein localized primarily in the mitochondrial matrix and has roles in inflammation and infection processes, mitochondrial ribosome biogenesis, and regulation of apoptosis and nuclear transcription. It has an N-terminal mitochondrial targeting peptide that is proteolytically processed after import into the mitochondrial matrix, where it forms a homotrimeric complex organized in a doughnut-shaped structure. Read More

    The Role of Sodium Bicarbonate in the Management of Some Toxic Ingestions.
    Int J Nephrol 2017 8;2017:7831358. Epub 2017 Aug 8.
    Department of Medicine, University of Kentucky College of Medicine, Lexington, KY, USA.
    Adverse reactions to commonly prescribed medications and to substances of abuse may result in severe toxicity associated with increased morbidity and mortality. According to the Center for Disease Control, in 2013, at least 2113 human fatalities attributed to poisonings occurred in the United States of America. In this article, we review the data regarding the impact of systemic sodium bicarbonate administration in the management of certain poisonings including sodium channel blocker toxicities, salicylate overdose, and ingestion of some toxic alcohols and in various pharmacological toxicities. Read More

    50 Years of Research in ARDS. Tidal Volume Selection in the Acute Respiratory Distress Syndrome.
    Am J Respir Crit Care Med 2017 Sep 20. Epub 2017 Sep 20.
    School of Medicine, Johns Hopkins University, Pulmonary and Critical Care, Baltimore, Maryland, United States ;
    Mechanical ventilation (MV) is critical in the management of many patients with the acute respiratory distress syndrome (ARDS). However, MV can also cause ventilator-induced lung injury (VILI). The selection of an appropriate tidal volume is an essential part of a lung-protective MV strategy. Read More

    Deceased Organ Donation From Pediatric Donors: Does the Literature Really Help Us? Implication for More Powerful Guidelines.
    Transplant Proc 2017 Oct;49(8):1708-1711
    Tracheal Diseases Research Center (TDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background: Brain-dead pediatric donors have always been the focus of attention because of the higher quality, utility, and possibility of their organ donation. However, donors under the age of 5 years always necessitate making more challenging management efforts, which are not clearly implied in most parts of the guidelines.

    Methods: The data obtained from 79 brain-dead pediatric donors of the Organ Procurement Unit of Masih Daneshvari Hospital, Tehran, Iran, were assessed. Read More

    Changes in acid-base and ion balance during exercise in normoxia and normobaric hypoxia.
    Eur J Appl Physiol 2017 Nov 15;117(11):2251-2261. Epub 2017 Sep 15.
    Department of Anesthesiology, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.
    Purpose: Both exercise and hypoxia cause complex changes in acid-base homeostasis. The aim of the present study was to investigate whether during intense physical exercise in normoxia and hypoxia, the modified physicochemical approach offers a better understanding of the changes in acid-base homeostasis than the traditional Henderson-Hasselbalch approach.

    Methods: In this prospective, randomized, crossover trial, 19 healthy males completed an exercise test until voluntary fatigue on a bicycle ergometer on two different study days, once during normoxia and once during normobaric hypoxia (12% oxygen, equivalent to an altitude of 4500 m). Read More

    Biallelic variants in WARS2 encoding mitochondrial tryptophanyl-tRNA synthase in six individuals with mitochondrial encephalopathy.
    Hum Mutat 2017 Dec 6;38(12):1786-1795. Epub 2017 Oct 6.
    Department of Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
    Mitochondrial protein synthesis involves an intricate interplay between mitochondrial DNA encoded RNAs and nuclear DNA encoded proteins, such as ribosomal proteins and aminoacyl-tRNA synthases. Eukaryotic cells contain 17 mitochondria-specific aminoacyl-tRNA synthases. WARS2 encodes mitochondrial tryptophanyl-tRNA synthase (mtTrpRS), a homodimeric class Ic enzyme (mitochondrial tryptophan-tRNA ligase; EC 6. Read More

    MELAS syndrome associated with a new mitochondrial tRNA-Val gene mutation (m.1616A>G).
    BMJ Case Rep 2017 Sep 11;2017. Epub 2017 Sep 11.
    Department of Neurology, Gifu Municipal Hospital, Gifu City, Japan.
    We describe the case of a 40-year-old-man with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome, with cardiomyopathy and severe heart failure. He had a mitochondrial transfer RNA (tRNA) mutation (m.1616A>G) of the (tRNA-Val) gene, and it was not found in MELAS syndrome ever before. Read More

    Peptide-mediated delivery of donor mitochondria improves mitochondrial function and cell viability in human cybrid cells with the MELAS A3243G mutation.
    Sci Rep 2017 Sep 6;7(1):10710. Epub 2017 Sep 6.
    Vascular and Genomic Center, Changhua Christian Hospital, Changhua, Taiwan.
    The cell penetrating peptide, Pep-1, has been shown to facilitate cellular uptake of foreign mitochondria but further research is required to evaluate the use of Pep-1-mediated mitochondrial delivery (PMD) in treating mitochondrial defects. Presently, we sought to determine whether mitochondrial transplantation rescue mitochondrial function in a cybrid cell model of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) disease. Following PMD, recipient cells had internalized donor mitochondria after 1 h, and expressed higher levels of normal mitochondrial DNA, particularly at the end of the treatment and 11 days later. Read More

    [Drowning-induced hyperfibrinolytic disseminated intravascular coagulation].
    Ugeskr Laeger 2017 Aug;179(35)
    This article summarizes the current knowledge of drowning-induced hyperfibrinolytic disseminated intravascular coagulation. Drowning induces respiratory failure with ensuing cardiac arrest, hypoxaemia and ischaemia. A coagulopathy is induced by ischaemia, acidosis and hypothermia, and clinically the patient develops uncontrolled bleeding due to hyperfibrinolysis. Read More

    Swimming Three Ice Miles within Fifteen Hours.
    Chin J Physiol 2017 08;60(4):197-206
    Gesundheitszentrum St. Gallen, St. Gallen, Switzerland.
    Ice Mile swimming (1608 m in water of below 5 °Celsius) is becoming increasingly popular. This case study aimed to identify body core temperature and selected haematological and biochemical parameters before and after repeated Ice Miles. An experienced ice swimmer completed three consecutive Ice Miles within 15 h. Read More

    Oxygen Administration Improves Survival but Worsens Cardiopulmonary Functions in Chlorine Exposed Rats.
    Am J Respir Cell Mol Biol 2017 Aug 28. Epub 2017 Aug 28.
    University of Colorado at Denver - Anschutz Medical Campus, 129263, Pediatric Pulmonary Medicine, Aurora, Colorado, United States ;
    Rationale: Chlorine is a highly reactive gas that can cause significant injury when inhaled. Unfortunately, its use as a chemical weapon has increased in recent years. Massive chlorine inhalation can cause death within 4h of exposure. Read More

    Evaluation of the expected ventilatory response to metabolic acidosis in chronic hemodialysis patients.
    Hemodial Int 2017 Aug 23. Epub 2017 Aug 23.
    Hemodialysis Unit, Maria Rosaria Clinic, Pompeii, Italy.
    Introduction: Expected pCO2 during metabolic acidosis should be computed to rule out superimposing respiratory acid-base disorders, the latter being featured by too high or too low pCO2 than expected. At least 4 different and inconsistent formulas exist. Based on the common practical rule, the reduction of pCO2 equals 1. Read More

    Dietary acid load and renal function have varying effects on blood acid-base status and exercise performance across age and sex.
    Appl Physiol Nutr Metab 2017 Aug 21:1-11. Epub 2017 Aug 21.
    a Biology of Physical Activity, Faculty of Sport and Health Sciences, University of Jyväskylä, PO Box 35, 40014 Jyväskylä, Finland.
    Diet composition influences acid-base status of the body. This may become more relevant as renal functional capacity declines with aging. We examined the effects of low (LD) versus high dietary acid load (HD) on blood acid-base status and exercise performance. Read More

    [Clinical Analysis of 10 Cases of B Cell Lymphoma-Associated Hemophagocytic Syndrome].
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 2017 Aug;25(4):1022-1029
    Department of Hematology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China.
    Objective: To investigate the clinical and laboratory features of patient with B cell lymphoma associated hemophagocytic syndrome(B-LAHS).

    Methods: The clinical data of 10 cases of B-LAHS were retrospectively analysed and the relevant literatures were reviewed.

    Results: The median age of 10 cases diagnosed as B-LAHS was 55. Read More

    Physiologic Features of Brain Death.
    Am Surg 2017 Aug;83(8):850-854
    Brain death is known to be associated with physiologic derangements but their incidence is poorly described. Knowledge of the changes that occur during brain death is important for management of the potential organ donor. Thus, we sought to characterize the pathophysiology that occurs during brain death in patients with traumatic injuries. Read More

    Successful Resuscitation of a Patient with Life-Threatening Metabolic Acidosis by Hemodialysis: A Case of Ethylene Glycol Intoxication.
    Case Rep Nephrol 2017 25;2017:9529028. Epub 2017 Jul 25.
    Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
    Background: Ethylene glycol intoxication causes severe metabolic acidosis and acute kidney injury. Fomepizole has become available as its antidote. Nevertheless, a prompt diagnosis is not easy because patients are often unconscious. Read More

    Combined Respiratory Chain Deficiency and UQCC2 Mutations in Neonatal Encephalomyopathy: Defective Supercomplex Assembly in Complex III Deficiencies.
    Oxid Med Cell Longev 2017 19;2017:7202589. Epub 2017 Jul 19.
    Department of Pediatrics, Salzburger Landeskliniken (SALK) and Paracelsus Medical University (PMU), 5020 Salzburg, Austria.
    Vertebrate respiratory chain complex III consists of eleven subunits. Mutations in five subunits either mitochondrial (MT-CYB) or nuclear (CYC1, UQCRC2, UQCRB, and UQCRQ) encoded have been reported. Defects in five further factors for assembly (TTC19, UQCC2, and UQCC3) or iron-sulphur cluster loading (BCS1L and LYRM7) cause complex III deficiency. Read More

    Practical approach to the patient with acute neuromuscular weakness.
    World J Clin Cases 2017 Jul;5(7):270-279
    Rajeev Nayak, Department of Neurology, Jabalpur Hospital and Research Centre, Jabalpur 482002, Madhyapradesh, India.
    Acute neuromuscular paralysis (ANMP) is a clinical syndrome characterized by rapid onset muscle weakness progressing to maximum severity within several days to weeks (less than 4 wk). Bulbar and respiratory muscle weakness may or may not be present. It is a common neurological emergency which requires immediate and careful investigations to determine the etiology because accurate diagnosis has significant impact on therapy and prognosis. Read More

    Effect of sodium bicarbonate on prolonged running performance: A randomized, double-blind, cross-over study.
    PLoS One 2017 10;12(8):e0182158. Epub 2017 Aug 10.
    Institute of Sports and Preventive Medicine, Saarland University, Saarbrücken, Germany.
    Background: The ability to sustain intense exercise seems to be partially limited by the body's capability to counteract decreases in both intra- and extracellular pH. While the influence of an enhanced buffering capacity via sodium bicarbonate (BICA) on short-term, high-intensity exercise performance has been repeatedly investigated, studies on prolonged endurance performances are comparatively rare, especially for running. The aim of the following study was to assess the ergogenic effects of an oral BICA substitution upon exhaustive intensive endurance running performance. Read More

    Synthetic cannabinoid induced acute respiratory depression: Case series and literature review.
    Respir Med Case Rep 2017 29;22:137-141. Epub 2017 Jul 29.
    Department of Internal Medicine, Division of Pulmonary Medicine and Critical Care Medicine, New York City Health+Hospitals Harlem, Columbia University College of Physicians and Surgeons, New York, NY, USA.
    Synthetic Cannabinoids are a street drug that is widely attainable and cheap compared to natural cannabis, and has variable potency and unpredictable effects with no commercially available diagnostic test to confirm its presence. Similar to natural cannabis, Synthetic Cannabinoid intoxication can present in several ways with the most common emergency room presentations to be of neurologic and psychiatric manifestation. The respiratory depressive effect of Synthetic Cannabinoids has not been well documented in medical literature. Read More

    Oral pyridoxine can substitute for intravenous pyridoxine in managing patients with severe poisoning with isoniazid and rifampicin fixed dose combination tablets: a case report.
    BMC Res Notes 2017 Aug 8;10(1):370. Epub 2017 Aug 8.
    University Medical Unit, National Hospital of Sri Lanka, Colombo 10, Sri Lanka.
    Background: Fixed drug combination of isoniazid and rifampicin is a rare cause of poisoning even in endemic countries for tuberculosis infection. Severe poisoning can cause severe morbidity and mortality if not treated promptly. Though intravenous pyridoxine is the preferred antidote for severe standard isoniazid poisoning it is not freely available even in best of care centers. Read More

    Atropine use may lead to post-operative respiratory acidosis in neonates receiving ductal ligation: A retrospective cohort study.
    Pediatr Neonatol 2017 Jul 20. Epub 2017 Jul 20.
    Department of Pediatrics, MacKay Children's Hospital, Taipei 10449, Taiwan; Department of Medicine, MacKay Medical College, New Taipei City 252, Taiwan. Electronic address:
    Background: Patent ductus arteriosus (PDA) is one of the most common cardiac conditions in preterm infants. Closure of the PDA in symptomatic patients can be achieved medically or surgically. Atropine is commonly administered in general anesthesia as a premedication in this age group but with limited evidence addressing the effect of its use. Read More

    Severe pulmonary edema following hyperbaric oxygen therapy for acute carbon monoxide poisoning: a case report and clinical experience.
    Undersea Hyperb Med 2017 May-Jun;44(3):287-291
    Department of Hyperbaric Oxygen, Navy General Hospital, PR China.
    Purpose: Pulmonary edema following hyperbaric oxygen (HBO₂) therapy is a rare clinical phenomenon. This case report describes such a patient - a 56-year-old woman who suffered from severe pulmonary edema after HBO₂ therapy for carbon monoxide (CO) poisoning.

    Case: Patient experienced ecphysesis and dyspnea suddenly after HBO₂ therapy (100% oxygen at 0. Read More

    Impact of membrane lung surface area and blood flow on extracorporeal CO2 removal during severe respiratory acidosis.
    Intensive Care Med Exp 2017 Dec 1;5(1):34. Epub 2017 Aug 1.
    Department of Pneumology and Critical Care Medicine, Cologne-Merheim Hospital, ARDS and ECMO Centre, Kliniken der Stadt Köln gGmbH, Witten/Herdecke University Hospital, Ostmerheimer Strasse 200, D-51109, Cologne, Germany.
    Background: Veno-venous extracorporeal CO2 removal (vv-ECCO2R) is increasingly being used in the setting of acute respiratory failure. Blood flow rates through the device range from 200 ml/min to more than 1500 ml/min, and the membrane surface areas range from 0.35 to 1. Read More

    Migraine in mitochondrial disorders: Prevalence and characteristics.
    Cephalalgia 2017 Jan 1:333102417723568. Epub 2017 Jan 1.
    1 Unità di Neurofisiopatologia, Area Neuroscienze, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.
    Background Migraine is a well-known feature of mitochondrial disorders (MDs). However, no systematic epidemiological data are available in large populations of patients. Aims The aim of this cross-sectional cohort study was to describe the prevalence and migraine characteristics in a large cohort of patients with mitochondrial encephalomyopathies. Read More

    Therapeutic hypothermia brings favorable neurologic outcomes in children with near drowning.
    Ci Ji Yi Xue Za Zhi 2016 Oct-Dec;28(4):180-182. Epub 2016 Sep 15.
    Department of Pediatrics, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
    A 1-year-10-month-old boy was admitted to our pediatric intensive care unit due to near drowning with pulmonary edema. A conventional ventilator with 100% oxygen supplementation was used initially, but was shifted to high frequency oscillatory ventilation as his oxygen saturation was around 84-88%. Therapeutic hypothermia was applied due to hypoxic ischemic encephalopathy with severe acidosis. Read More

    Carbon dioxide narcosis due to inappropriate oxygen delivery: a case report.
    J Med Case Rep 2017 Jul 28;11(1):204. Epub 2017 Jul 28.
    University of Bern, Medical Faculty, Bern, Switzerland.
    Background: Oxygen delivery to patients with chronic obstructive pulmonary disease may be challenging because of their potential hypoxic ventilatory drive. However, some oxygen delivery systems such as non-rebreathing face masks with an oxygen reservoir bag require high oxygen flow for adequate oxygenation and to avoid carbon dioxide rebreathing.

    Case Presentation: A 72-year-old Caucasian man with severe chronic obstructive pulmonary disease was admitted to the emergency department because of worsening dyspnea and an oxygen saturation of 81% measured by pulse oximetry. Read More

    Two Cases of Pneumatosis Cystoides Intestinalis With Intraperitoneal Free Air.
    Gastroenterology Res 2017 Jun 30;10(3):208-211. Epub 2017 Jun 30.
    Department of Internal Medicine, Kawasaki Hospital, Kobe, Japan.
    Intraperitoneal free air (IFA) is sometimes accompanied by pneumatosis cystoides intestinalis (PCI); therefore, proper diagnosis is essential for PCI management. We report two cases of PCI with IFA. A 70-year-old female taking anti-psychotic medication for schizophrenia presented with repeated vomiting and high-grade fever. Read More

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