7,873 results match your criteria Respiratory Acidosis


Editorialist's Reply to: Whither the Bicarbonate Era.

Am J Respir Crit Care Med 2020 May 27. Epub 2020 May 27.

University of Pittsburgh, Pittsburgh, Pennsylvania, United States.

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http://dx.doi.org/10.1164/rccm.202005-1747LEDOI Listing

Sudden Cardiac Arrest in an Asymptomatic Zinc Phosphide-Poisoned Patient: A Case Report.

Cardiovasc Toxicol 2020 May 25. Epub 2020 May 25.

Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Zinc phosphide is a gray to black powder mainly used as a rodenticide. In contact with gastric fluid, it releases phosphine which is the main toxic material of this compound. Phosphine interferes with oxidative respiratory cycle of the cells, but is generally expected to manifest its toxicity with prodromal signs and symptoms including abdominal pain, nausea and vomiting, metabolic acidosis, and increased liver function tests. Read More

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http://dx.doi.org/10.1007/s12012-020-09578-2DOI Listing

Predictors of 15-Day Survival for the Intensive Care Unit Patient on Continuous Renal Replacement Therapy: A Retrospective Analysis.

Cureus 2020 May 18;12(5):e8175. Epub 2020 May 18.

Internal Medicine, Zucker School of Medicine at Hofstra Northwell, Staten Island University Hospital Northwell Health, Staten Island, USA.

Purpose In the intensive care unit (ICU), acute renal failure is mostly part of multiple organ dysfunction syndromes with mortality ranging from 28%-90%, continuous renal replacement therapy (CRRT) is the predominant mode of RRT used in ICU. The main objective of the study was to evaluate the outcomes in patients with acute kidney injury (AKI) on CRRT in the ICU. Methods A retrospective chart review was conducted for all ICU patients with acute renal failure on CRRT in a tertiary care teaching hospital. Read More

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http://dx.doi.org/10.7759/cureus.8175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237053PMC

A Case of Toxicity from Cannabidiol Gummy Ingestion.

Cureus 2020 Apr 16;12(4):e7688. Epub 2020 Apr 16.

Internal Medicine, NCH Healthcare System, Naples, USA.

A 56-year-old male with no known history of substance abuse and no known prior medical conditions presented via ambulance to the emergency department after being found by coworkers with bizarre behavior, vomiting, and slurred speech. He had legally purchased cannabidiol (CBD) gummies marketed for pain and anxiety relief at a gas station several hours prior. Vitals upon arrival were temperature 36. Read More

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http://dx.doi.org/10.7759/cureus.7688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233499PMC

Interventionist videothermometry: a new model of cardiac ischemia evaluation.

BMC Vet Res 2020 May 19;16(1):142. Epub 2020 May 19.

Darcy Ribeiro North Fluminense State University, Alberto Lamego Avenue, Campos dos Goytacazes, 2000, Brazil.

Background: The purpose of the present study was to evaluate, through videothermometry, the temperature variation in the hearts of rabbits, that underwent induced myocardial ischemia and reperfusion.

Results: A total of 20 female rabbits were divided into two groups: a treated group and a sham group, the treatment group underwent 5 min of cardiac arrest and reperfusion, using the inflow occlusion technique. Throughout the experiment, the animals were monitored by videothermometry, observing the thermal variations of the myocardial tissue. Read More

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http://dx.doi.org/10.1186/s12917-020-02358-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236240PMC

Extracorporeal Membrane Oxygenation for Coronavirus Disease 2019-Induced Acute Respiratory Distress Syndrome: A Multicenter Descriptive Study.

Crit Care Med 2020 May 18. Epub 2020 May 18.

Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.

Objectives: Severe acute respiratory distress syndrome is complicated with coronavirus disease 2019 and extracorporeal membrane oxygenation support may be necessary in severe cases. This study is to summarize the clinical features, extracorporeal membrane oxygenation characteristics, and outcomes of patients with severe acute respiratory syndrome coronavirus 2 pneumonia received extracorporeal membrane oxygenation.

Design: Descriptive study from two hospitals. Read More

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http://dx.doi.org/10.1097/CCM.0000000000004447DOI Listing

[Management of patients with MELAS syndrome : A case report and general characteristics from an anesthesiological perspective].

Anaesthesist 2020 May 18. Epub 2020 May 18.

Klinik für Anästhesiologie, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland.

Background: Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome is a rare progressive disease with acute neurological episodes caused by a mitochondriopathy. Due to a defect of oxidative phosphorylation in the respiratory chain, there is impaired mitochondrial energy production with subsequent lactic acidosis, especially in situations with increased stress. Due to the high risk of metabolic derailment MELAS syndrome is a great challenge with respect to the perioperative management of anesthesia. Read More

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http://dx.doi.org/10.1007/s00101-020-00793-8DOI Listing

Intralipid and haemodialysis in caffeine overdose.

BMJ Case Rep 2020 May 14;13(5). Epub 2020 May 14.

Critical Care, Queen Elizabeth Woolwich, London, UK.

A 26-year-old woman presented after an intentional ingestion of 20 g of caffeine. She suffered a profound respiratory alkalosis with metabolic acidosis, hypokalaemia and sustained polymorphic ventricular tachycardia. She was treated with intravenous intralipid and haemodialysis, and her arrhythmia was controlled using magnesium sulphate. Read More

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http://dx.doi.org/10.1136/bcr-2020-234256DOI Listing

A 7-Year Trend of Malaria at Primary Health Facilities in Northwest Ethiopia.

J Parasitol Res 2020 29;2020:4204987. Epub 2020 Jan 29.

Department of Medical Parasitology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Malaria is a severe parasitic disease that can progress to complications of the nervous system, respiratory distress, renal problems, metabolic acidosis, and hypoglycemia which can result in death in case of delay or absence of appropriate treatment. Even though health service facilities and vector control strategy in the community are implemented as control measures, variations in temperature and rainfall that can affect the life cycle of parasite are among the factors of malaria prevalence over the years. The aim of this trend analysis was to assess the prevalence and the impact of malaria over the seasons and years. Read More

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http://dx.doi.org/10.1155/2020/4204987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204144PMC
January 2020

Reevaluation of Lung Injury in TNF-Induced Shock: The Role of the Acid Sphingomyelinase.

Mediators Inflamm 2020 1;2020:3650508. Epub 2020 May 1.

Institute of Immunology, Christian-Albrechts University, Arnold-Heller-Str. 3, 24105 Kiel, Germany.

Tumor necrosis factor (TNF) is a well-known mediator of sepsis. In many cases, sepsis results in multiple organ injury including the lung with acute respiratory distress syndrome (ARDS). More than 20-year-old studies have suggested that TNF may be directly responsible for organ injury during sepsis. Read More

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http://dx.doi.org/10.1155/2020/3650508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211256PMC

Extracorporeal membrane oxygenation and V/Q ratios: an ex vivo analysis of CO clearance within the Maquet Quadrox-iD oxygenator.

Perfusion 2020 May;35(1_suppl):29-33

Department of Intensive Care and Hyperbaric Medicine, The Alfred Hospital, Melbourne, VIC, Australia.

While hypercapnia is typically well treated with modern membrane oxygenators, there are cases where respiratory acidosis persists despite maximal extracorporeal membrane oxygenation support. To better understand the physiology of gas exchange within the membrane oxygenator, CO clearance within an adult Maquet Quadrox-iD oxygenator was evaluated at varying blood CO tensions and V/Q ratios in an ex vivo extracorporeal membrane oxygenation circuit. A closed blood-primed circuit incorporating two Maquet Quadrox-iD oxygenators in series was attached to a Maquet PLS Rotaflow pump. Read More

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http://dx.doi.org/10.1177/0267659120906767DOI Listing

Acute Myocardial Infarction among Hospitalizations for Heat Stroke in the United States.

J Clin Med 2020 May 6;9(5). Epub 2020 May 6.

Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok 10400, Thailand.

Background: This study aimed to assess the risk factors and impact of acute myocardial infarction on in-hospital treatments, complications, outcomes, and resource utilization in hospitalized patients for heat stroke in the United States.

Methods: Hospitalized patients with a principal diagnosis of heat stroke were identified in the National Inpatient Sample dataset from the years 2003 to 2014. Acute myocardial infarction was identified using the hospital International Classification of Diseases, Ninth Revision (ICD-9), diagnosis of 410. Read More

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http://dx.doi.org/10.3390/jcm9051357DOI Listing

Prehospital reversal of profound respiratory acidosis and hypercapnic coma by non-invasive ventilation: a report of two cases.

Authors:
P E Fubini L Suppan

Int J Emerg Med 2020 May 7;13(1):22. Epub 2020 May 7.

Division of Emergency Medicine, Department of Anaesthesiology, Clinical Pharmacology, Intensive Care and Emergency Medicine, Geneva University Hospitals and Faculty of Medicine University of Geneva, CH-1211, Geneva, Switzerland.

Background: In chronic obstructive pulmonary disease (COPD) patients with acute respiratory failure (ARF), non-invasive ventilation (NIV) is generally recommended and has proven its benefits by reducing endotracheal intubation (ETI) rates, intensive care unit (ICU) admissions, complications, and mortality. Choosing between immediate ETI or NIV trial is often difficult when such patients present with an altered mental status. Some guidelines recommend avoiding NIV when consciousness is impaired given the risk of aspiration, and some authors suggest that a pH < 7. Read More

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http://dx.doi.org/10.1186/s12245-020-00284-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206709PMC

Extracellular Acidosis and mTOR Inhibition Drive the Differentiation of Human Monocyte-Derived Dendritic Cells.

Cell Rep 2020 May;31(5):107613

INBIRS, Universidad de Buenos Aires (UBA)-CONICET, Buenos Aires, Argentina. Electronic address:

During inflammation, recruited monocytes can differentiate either into macrophages or dendritic cells (DCs); however, little is known about the environmental factors that determine this cell fate decision. Low extracellular pH is a hallmark of a variety of inflammatory processes and solid tumors. Here, we report that low pH dramatically promotes the differentiation of monocytes into DCs (monocyte-derived DCs [mo-DCs]). Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107613DOI Listing

The role of carotid bodies in the generation of active inspiratory and expiratory responses to exercise in rats.

Exp Physiol 2020 May 2. Epub 2020 May 2.

Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.

New Findings: What is the central question of this study? What is the carotid bodies' contribution to active inspiratory and expiratory response to exercise? What is the main finding and its importance? Removal of the carotid bodies reduced the active inspiratory and expiratory responses of diaphragm and abdominal internal oblique muscles, respectively, to high-intensity, but not to low-intensity, exercise in rats. Removal of the carotid bodies increased and decreased arterial pH in response to high-intensity exercise. The carotid bodies contribute to the inspiratory and expiratory adjustments to high-intensity exercise in rats. Read More

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http://dx.doi.org/10.1113/EP088203DOI Listing

Current targeted therapeutics against COVID-19: Based on first-line experience in China.

Pharmacol Res 2020 Apr 30;157:104854. Epub 2020 Apr 30.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu, 210029, China. Electronic address:

SARS-CoV-2 is a novel strain, causing a global pandemic since the end of 2019. The majority of patients showed nonspecific symptoms such as fever, dry cough, and fatigue. Most patients have a good prognosis while some with severe conditions could rapidly progress to acute respiratory distress syndrome, septic shock, metabolic acidosis, coagulation dysfunction, and even die. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.104854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192075PMC

Validation of RESP and PRESERVE score for ARDS patients with pumpless extracorporeal lung assist (pECLA).

BMC Anesthesiol 2020 May 2;20(1):102. Epub 2020 May 2.

Department of Intensive Care Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstr 30, 52074, Aachen, Germany.

Background: RESP score and PRESERVE score have been validated for veno-venous Extracorporeal Membrane Oxygenation in severe ARDS to assume individual mortality risk. ARDS patients with low-flow Extracorporeal Carbon Dioxide Removal, especially pumpless Extracorporeal Lung Assist, have also a high mortality rate, but there are no validated specific or general outcome scores. This retrospective study tested whether these established specific risk scores can be validated for pumpless Extracorporeal Lung Assist in ARDS patients in comparison to a general organ dysfunction score, the SOFA score. Read More

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http://dx.doi.org/10.1186/s12871-020-01010-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195797PMC

Steroid-induced Lactic Acidosis in Diffuse Large B-cell Lymphoma.

Cureus 2020 Mar 28;12(3):e7446. Epub 2020 Mar 28.

Internal Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, USA.

A previously healthy 53-year-old male with primary membranous nephropathy (positive anti phospholipase A2 antibody) presented to our hospital with worsening cough, shortness of breath, hypotension, and malaise. During his hospital stay, he quickly progressed to overt respiratory failure requiring mechanical ventilation. Upon further workup, he met clinical criteria for tumor lysis syndrome due to an unknown diffuse large B-cell lymphoma, who underwent rapid cytolysis after starting stress dose steroids. Read More

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http://dx.doi.org/10.7759/cureus.7446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186090PMC

Calcium Channel Blocker Toxicity Causing Acute Respiratory Distress Syndrome: A Commonly Used Drug Triggering a Life-Threatening Condition.

WMJ 2020 Mar;119(1):66-68

Marshfield Medical Center, Marshfield, Wisconsin.

Introduction: Calcium channel blockers (CCBs) are commonly used but have the potential to cause substantial toxicity. One such underreported toxicity of CCB use is the development of acute respiratory distress syndrome (ARDS).

Case Presentation: 44-year-old previously healthy woman presented to the emergency department (ED) having taken 60 tablets of 125 mg extended-release verapamil and 90 tablets of 0. Read More

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Acute Hyperglycemic Crises with Coronavirus Disease-19: Case Reports.

Diabetes Metab J 2020 04;44(2):349-353

Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.

Since the first case was contracted by coronavirus disease-19 (COVID-19) in Daegu, Korea in February 2020, about 6,800 cases and 130 deaths have been reported on April 9, 2020. Recent studies have reported that patients with diabetes showed higher mortality and they had a worse prognosis than the group without diabetes. In poorly controlled patients with diabetes, acute hyperglycemic crises such as diabetic ketoacidosis (DKA) or hyperosmolar hyperglycemic state (HHS) also might be precipitated by COVID-19. Read More

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http://dx.doi.org/10.4093/dmj.2020.0091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188962PMC

Study of Acid-Base Disorders and Biochemical Findings of Patients in a Tertiary Care Hospital: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2019 Nov-Dec;57(220):432-436

Department of Biochemistry, Nobel Medical College Teaching Hospital, Biratnagar, Nepal.

Introduction: Acid base disorder is a condition characterized by alteration in blood pH by the imbalance between the components of blood leading to a life threatening situation. The main aim of this study was to find the prevalence of acid-base disorders and biochemical findings of such disorders in patients in a tertairy care hospital.

Methods: This descriptive cross-sectional study was conducted in Nobel Medical College Teaching Hospital from 1st September, 2018 to 31st August, 2019. Read More

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Hypercapnia Exacerbates the Blood-Brain Barrier Disruption Via Promoting HIF-1a Nuclear Translocation in the Astrocytes of the Hippocampus: Implication in Further Cognitive Impairment in Hypoxemic Adult Rats.

Neurochem Res 2020 Apr 23. Epub 2020 Apr 23.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.

Hypercapnia in combination with hypoxemia is usually present in severe respiratory disease in the intensive care unit (ICU) and can lead to more severe cognitive dysfunction. Increasing evidence has indicated that the compromised blood-brain barrier (BBB) in the hippocampus in hypoxemia conditions can result in cognitive dysfunction. However, the role and underlying mechanism of hypercapnia in the BBB disruption remains poorly known. Read More

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http://dx.doi.org/10.1007/s11064-020-03038-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224048PMC

[Acute severe oral poisoning with 1,4-butandiol and ethanol with the development of coma].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(3):77-81

Dzhanelidze St. Petersburg Research Institute of Emergency Medicine, St. Petersburg, Russia.

A case of acute oral poisoning by 1.4-butanediol, complicated by the development of severe hypoxia in a 34-year-old patient actively engaged in bodybuilding, is presented. The psychoactive substance was used by the patient to increase sexual activity and physical stamina. Read More

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http://dx.doi.org/10.17116/jnevro202012003177DOI Listing
January 2020

Autosomal dominant transmission of transient neonatal lactic acidosis: a case report.

BMC Pediatr 2020 Apr 20;20(1):177. Epub 2020 Apr 20.

Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

Background: Lactic acidosis is a common finding in neonates, in whom mitochondrial dysfunction is often secondary to tissue hypoperfusion, respiratory failure, and/or sepsis. Primary (non-physiological) lactic acidosis is comparatively rare, and suggests the presence of an inborn error of mitochondrial energy metabolism. Optimal medical management and accurate prognostication requires the correct determination of the etiology of lactic acidosis in a given patient. Read More

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http://dx.doi.org/10.1186/s12887-020-02085-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168962PMC

A Novel PUS1 Mutation in 2 Siblings with MLASA Syndrome: A Review of the Literature.

J Pediatr Hematol Oncol 2020 Apr 13. Epub 2020 Apr 13.

Departments of Pediatric Metabolism.

Myopathy, lactic acidosis, and sideroblastic anemia (MLASA) is a rare mitochondrial disorder characterized by MLASA. Variable features of this condition include failure to thrive, and developmental delay or intellectual disability. Additional symptoms consist of cognitive impairment, skeletal and dental abnormalities, delayed motor milestones, cardiomyopathy, dysphagia, and respiratory insufficiency. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001806DOI Listing

Evaluation of cell metabolic adaptation in wound and tumour by Fluorescence Lifetime Imaging Microscopy.

Sci Rep 2020 Apr 14;10(1):6289. Epub 2020 Apr 14.

Unit of Advanced Optical Microscopy, IRCCS, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.

Acidic pH occurs in acute wounds progressing to healing as consequence of a cell metabolic adaptation in response to injury-induced tissue hypoperfusion. In tumours, high metabolic rate leads to acidosis affecting cancer progression. Acidic pH affects activities of remodelling cells in vitro. Read More

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http://dx.doi.org/10.1038/s41598-020-63203-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156395PMC

Clinical and Epidemiological Characteristics of Severe Acute Adult Poisoning Cases in Martinique: Implicated Toxic Exposures and Their Outcomes.

Toxics 2020 Apr 9;8(2). Epub 2020 Apr 9.

Intensive Care Unit, University Hospital of Martinique, Fort-de-France, 97261 Martinique, France.

The epidemiology of severe acute poisonings in the French overseas departments of the Americas remains poorly reported. The main objective of this study was to determine the epidemiology and characteristics of severe acutely poisoned adult patients.

Methods: A retrospective descriptive study was conducted from 1 January 2000 to 31 December 2010 in severely poisoned patients presenting to the emergency department (ED) of the University Hospital of Martinique, and the general public hospitals of Lamentin and Trinité. Read More

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http://dx.doi.org/10.3390/toxics8020028DOI Listing

Critical Care Admission of an HIV Patient with Diabetic Ketoacidosis Secondary to Pembrolizumab.

Case Rep Crit Care 2020 25;2020:8671530. Epub 2020 Mar 25.

Department of Critical Care & Respiratory Care, Division of Anesthesiology, Critical Care and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Pembrolizumab is a checkpoint inhibitor that targets the programmed cell death-1 receptor (PD-1) and has shown to be effective against several malignancies, including lung cancer. However, life-threatening immune-related adverse events can result from these immunotherapy treatments. . Read More

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http://dx.doi.org/10.1155/2020/8671530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132356PMC

Arterial Blood Gas Analysis of Patients with Tramadol-induced Seizure; a Cross Sectional Study.

Arch Acad Emerg Med 2020 1;8(1):e14. Epub 2020 Mar 1.

Toxicological Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Tramadol is an active analgesic drug that is commonly used to treat moderate to severe pain. The present study aimed to assess the arterial blood gas (ABG) analysis of patients with tramadol-induced seizure (TIS).

Methods: This prospective cross-sectional study was performed on 50 TIS cases that were referred to emergency department within a maximum of one hour after their last episode of seizure. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130435PMC

Isovaleric Acidemia: A Rare Case of an Inborn Error of Metabolism.

Cureus 2020 Feb 29;12(2):e7150. Epub 2020 Feb 29.

Pediatrics, Rehman Medical Institute, Peshawar, PAK.

Isovaleric acidemia (IVA) is an autosomal recessive disease of the leucine metabolism due to a deficiency of isovaleryl-CoA dehydrogenase (IVD). We report the case of a six-month-old girl admitted with a seven-day history of fever, cough, stridor, vomiting, and respiratory distress. Second-degree consanguinity was documented between the parents. Read More

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http://dx.doi.org/10.7759/cureus.7150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108672PMC
February 2020

Pioglitazone and Deoxyribonucleoside Combination Treatment Increases Mitochondrial Respiratory Capacity in m.3243A>G MELAS Cybrid Cells.

Int J Mol Sci 2020 Mar 20;21(6). Epub 2020 Mar 20.

School of Life and Environmental Sciences, Faculty of Science, Engineering and Built Environment, Deakin University, Geelong 3216, Australia.

The lack of effective treatments for mitochondrial disease has seen the development of new approaches, including those that aim to stimulate mitochondrial biogenesis to boost ATP generation above a critical disease threshold. Here, we examine the effects of the peroxisome proliferator-activated receptor γ (PPARγ) activator pioglitazone (PioG), in combination with deoxyribonucleosides (dNs), on mitochondrial biogenesis in cybrid cells containing >90% of the m.3243A>G mutation associated with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). Read More

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http://dx.doi.org/10.3390/ijms21062139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139379PMC

Acetazolamide Causes Worsening Acidosis in Uncompensated COPD Exacerbations: Increased Awareness Needed for Patient Safety.

Authors:
Jennifer L Cole

J Emerg Med 2020 Mar 30. Epub 2020 Mar 30.

Veterans Healthcare System of the Ozarks, Fayetteville, Arkansas.

Background: Acetazolamide has been studied extensively in post-hypercapnic alkalosis as a tool to facilitate ventilator weaning in chronic obstructive pulmonary disease (COPD). It has also been utilized to facilitate respiratory drive in nonmechanically ventilated patients with COPD. Although this is generally a forgiving intervention, providers must carefully select patients for this medication, as it can cause severe acidosis and deterioration of clinical status in severe COPD cases. Read More

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http://dx.doi.org/10.1016/j.jemermed.2020.01.019DOI Listing

Calabadion 1 selectively reverses respiratory and central nervous system effects of fentanyl in a rat model.

Br J Anaesth 2020 Mar 30. Epub 2020 Mar 30.

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg-Essen, Essen, Germany. Electronic address:

Background: We hypothesised that Calabadion 1, an acyclic cucurbit[n]uril molecular container, reverses fentanyl-induced respiratory depression and dysfunction of the CNS.

Methods: Experiments were conducted in male Sprague-Dawley rats. A constant-rate i. Read More

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http://dx.doi.org/10.1016/j.bja.2020.02.019DOI Listing
March 2020
4.853 Impact Factor

Risk factors associated with disease progression in a cohort of patients infected with the 2019 novel coronavirus.

Ann Palliat Med 2020 Mar 17;9(2):428-436. Epub 2020 Mar 17.

Department of Respiratory Medicine, The Ninth Hospital of Nanchang, Nanchang 330002, China.

Background: The emerging infection of the 2019 novel coronavirus (2019-nCoV) in late December, 2019 in Wuhan, China, has caused an extreme health concern, with many patients having progressed to acute respiratory disease or other complications in a short period. Meanwhile, the risk factors associated with the disease progression still remain elusive.

Methods: A cohort of 17 patients with laboratory-confirmed 2019-nCoV infections who were admitted to the Ninth Hospital of Nanchang between January 28 and February 6, 2020, were enrolled in this study. Read More

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http://dx.doi.org/10.21037/apm.2020.03.26DOI Listing

Alleviation of methyl isocyanate-induced airway obstruction and mortality by tissue plasminogen activator.

Ann N Y Acad Sci 2020 Mar 31. Epub 2020 Mar 31.

Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Methyl isocyanate (MIC, "Bhopal agent") is a highly reactive, toxic industrial chemical. Inhalation of high levels (500-1000 ppm) of MIC vapor is almost uniformly fatal. No therapeutic interventions other than supportive care have been described that can delay the onset of illness or death due to MIC. Read More

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http://dx.doi.org/10.1111/nyas.14344DOI Listing

A fatal case of severe systemic varicella zoster infection in a patient with chronic use of immunosuppressive agents for cutaneous vasculitis.

IDCases 2020 9;19:e00667. Epub 2019 Nov 9.

Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University, School of Medicine, Taipei, Taiwan.

Acute varicella zoster virus (VZV) infection is a common condition in children, which is considered a mild, self-limited disease with diffuse skin vesicular rash. However, disseminated VZV infection with multiple organ involvement can occur in immunocompromised patients with impaired T cell immunity including solid or hematopoietic stem cell transplant recipients, receiving immunosuppressive therapy, leukemia, lymphoma, and HIV infection. Prompt antiviral therapy is mandatory in those immunocompromised persons. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093748PMC
November 2019

Spironolactone-furosemide combination therapy and acid-base disorders in liver cirrhosis patients
.

Int J Clin Pharmacol Ther 2020 May;58(5):261-267

Objective: Respiratory alkalosis (RA) and dilutional hyperchloremic acidosis (DHA) are the most common acid-base balance (ABB) disorders in patients with liver cirrhosis. The aims of this study were to clarify whether RA develops in relation to DHA via respiratory compensation of metabolic acidosis and whether spironolactone in combination with low-dose furosemide - diuretics known to ameliorate DHA - positively affects RA in liver cirrhosis patients.

Materials And Methods: 59 patients with advanced cirrhosis were divided into two groups. Read More

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http://dx.doi.org/10.5414/CP203624DOI Listing

ORAL HALOPERIDOL PREMEDICATION TO REDUCE CAPTURE STRESS PRIOR TO XYLAZINE-KETAMINE ANESTHESIA IN CAPTIVE SPOTTED DEER ().

J Zoo Wildl Med 2020 Mar;51(1):88-95

Teaching Veterinary Clinical Complex, College of Veterinary and Animal Sciences, Mannuthy, Thrissur, Kerala 680651, India.

A prospective clinical trial was performed to evaluate the efficacy of haloperidol premedication prior to xylazine-ketamine anesthesia with a goal of reducing capture stress in adult male captive spotted deer (). On the morning of the study, deer were fed a banana either containing haloperidol tablets (1 mg/kg) (haloperidol group, = 10) or without haloperidol (placebo group, = 10). Six hours postadministration, xylazine (3 mg/kg) and ketamine (2 mg/kg) was administered intramuscularly via a dart. Read More

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http://dx.doi.org/10.1638/2017-0034DOI Listing

Uni-hemispheric hyperperfusion in the early postictal state: case report.

BMC Neurol 2020 Mar 24;20(1):108. Epub 2020 Mar 24.

Department of Clinical Radiology and Neuroradiology, University Hospital Muenster, Albert-Schweitzer-Campus 1, Building A1, 48149, Muenster, Germany.

Background: In the emergency setting of acute ischemic stroke, seizures have been reported in up to 4% of patients. In the absence of arterial occlusion, seizures may also cause abnormalities in CT perfusion in 78% of cases when the time window from onset to imaging is short. Both hyperperfusion and hypoperfusion in the postictal state have been described. Read More

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http://dx.doi.org/10.1186/s12883-020-01665-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093958PMC

ISCCM Guidelines for the Use of Non-invasive Ventilation in Acute Respiratory Failure in Adult ICUs.

Indian J Crit Care Med 2020 Jan;24(Suppl 1):S61-S81

Department of Division of Critical Care Medicine, Department of Anaesthesia, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India, , e-mail:

A. ACUTE HYPERCAPNIC RESPIRATORY FAILURE A1. Acute Exacerbation of COPD: Recommendations: NIV should be used in management of acute exacerbation of COPD in patients with acute or acute-on-chronic respiratory acidosis (pH = 7. Read More

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http://dx.doi.org/10.5005/jp-journals-10071-G23186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085817PMC
January 2020

Atherosclerosis Can Be Mitochondrial: A Review.

Authors:
Josef Finsterer

Cureus 2020 Feb 13;12(2):e6987. Epub 2020 Feb 13.

Neurology, Krankenanstalt Rudolfstiftung, Vienna, AUT.

One of the systems that are potentially affected in mitochondrial disorders, but hardly get systematically investigated, are the arteries. One of the phenotypic manifestations in arteries is atherosclerosis. This review focuses on the current knowledge and recent advances of mitochondrial atherosclerosis. Read More

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http://dx.doi.org/10.7759/cureus.6987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075516PMC
February 2020

Unchanged cerebrovascular CO reactivity and hypercapnic ventilatory response during strict head-down tilt bed rest in a mild hypercapnic environment.

J Physiol 2020 Mar 20. Epub 2020 Mar 20.

NASA Johnson Space Center, Houston, TX, USA.

Key Points: Carbon dioxide levels are mildly elevated on the International Space Station and it is unknown whether this chronic exposure causes physiological changes to astronauts. We combined ∼4 mmHg ambient with the strict head-down tilt bed rest model of spaceflight and this led to the development of optic disc oedema in one-half of the subjects. We demonstrate no change in arterialized , cerebrovascular reactivity to CO or the hypercapnic ventilatory response. Read More

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http://dx.doi.org/10.1113/JP279383DOI Listing

Endogenous brain-sparing responses in brain pH and PO in a rodent model of birth asphyxia.

Acta Physiol (Oxf) 2020 Mar 16:e13467. Epub 2020 Mar 16.

Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences, University of Helsinki, Helsinki, Finland.

Aim: To study brain-sparing physiological responses in a rodent model of birth asphyxia which reproduces the asphyxia-defining systemic hypoxia and hypercapnia.

Methods: Steady or intermittent asphyxia was induced for 15-45 minutes in anaesthetized 6- and 11-days old rats and neonatal guinea pigs using gases containing 5% or 9% O plus 20% CO (in N ). Hypoxia and hypercapnia were induced with low O and high CO respectively. Read More

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http://dx.doi.org/10.1111/apha.13467DOI Listing

Intermittent Hemodialysis for Managing Metabolic Acidosis During Resuscitation of Septic Shock: A Descriptive Study.

Crit Care Explor 2019 Dec 10;1(12):e0065. Epub 2019 Dec 10.

Department of Intensive Care Medicine, Kameda Medical Center, Kamogawa, Chiba, Japan.

Septic shock is often complicated by severe metabolic acidosis, for which renal replacement therapy may be considered. However, little is known about the use of intermittent hemodialysis to manage this condition. The aim of this study was to compare physiologic and biochemical variables and vasopressor requirements before and after intermittent hemodialysis among patients who received intermittent hemodialysis to manage metabolic acidosis during resuscitation of septic shock. Read More

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http://dx.doi.org/10.1097/CCE.0000000000000065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063923PMC
December 2019

Unusual Presentation of Methicillin-Resistant Colitis Complicated with Acute Appendicitis.

J Glob Infect Dis 2020 Jan-Mar;12(1):34-36. Epub 2020 Feb 19.

Division of Pulmonary and Critical Care, St. Joseph's University Medical Center, Paterson, NJ, USA.

Clostridium difficile colitis has been the most recognized bacterial enterocolitis for years and other bacteria such as Staphylococcus colitis has been relegated. Staphylococcus enterocolitis following antibiotics had been one of the most frequent complications in surgical patients in the 1950s and 1960s and now reappear with more resistance such as methicillin-resistant(MRSA) colitis which brings a new challenge. A 32-year-old Hispanic female with a history of type I diabetes mellitus presenting with altered sensorium and a 2-day history of watery, nonbloody diarrhea, intractable emesis, and diffuse crampy abdominal pain. Read More

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http://dx.doi.org/10.4103/jgid.jgid_117_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045764PMC
February 2020

Subcutaneous emphysema and hypercarbia as a complication of laparoscopic procedure: case report.

J Surg Case Rep 2020 Mar 6;2020(3):rjz415. Epub 2020 Mar 6.

Department of Anaesthesia, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Subcutaneous emphysema (SE) is a rare complication of laparoscopic procedures, with an incidence rate of only 0.43-2.3%. Read More

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http://dx.doi.org/10.1093/jscr/rjz415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059889PMC

Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly.

Nat Commun 2020 Mar 11;11(1):1312. Epub 2020 Mar 11.

Cardiovascular Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore.

The emergence of small open reading frame (sORF)-encoded peptides (SEPs) is rapidly expanding the known proteome at the lower end of the size distribution. Here, we show that the mitochondrial proteome, particularly the respiratory chain, is enriched for small proteins. Using a prediction and validation pipeline for SEPs, we report the discovery of 16 endogenous nuclear encoded, mitochondrial-localized SEPs (mito-SEPs). Read More

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http://dx.doi.org/10.1038/s41467-020-14999-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066179PMC
March 2020
10.742 Impact Factor

[Influence of the blood gas composition and mechanical ventilation parameters of the medical evacuation prognosis of critically ill patients.]

Klin Lab Diagn 2020 ;65(2):84-89

GBUS TO «Regional clinical hospital №1», 625032, Tyumen, Russia.

The clinical estimation of the state of patient is one of the basic components of the checking of the state of patient, but more precise and more objective indices today become necessary. The arterial blood gases analysis helps to select the optimum regime of mechanical ventilation. The medical evacuation of the critically ill patients frequently requires the correction of the parameters of respiratory support. Read More

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http://dx.doi.org/10.18821/0869-2084-2020-65-2-84-89DOI Listing
January 2020

An integrative approach to the regulation of mitochondrial respiration during exercise: Focus on high-intensity exercise.

Redox Biol 2020 Feb 25:101478. Epub 2020 Feb 25.

Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, 35017, Las Palmas de Gran Canaria, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe "Físico" (s/n), 35017, Las Palmas de Gran Canaria, Canary Islands, Spain.

During exercise, muscle ATP demand increases with intensity, and at the highest power output, ATP consumption may increase more than 100-fold above the resting level. The rate of mitochondrial ATP production during exercise depends on the availability of O, carbon substrates, reducing equivalents, ADP, P, free creatine, and Ca. It may also be modulated by acidosis, nitric oxide and reactive oxygen and nitrogen species (RONS). Read More

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http://dx.doi.org/10.1016/j.redox.2020.101478DOI Listing
February 2020

Update on extracorporeal carbon dioxide removal: a comprehensive review on principles, indications, efficiency, and complications.

Perfusion 2020 Mar 10:267659120906048. Epub 2020 Mar 10.

Department of Medicine I, Intensive Care Unit, Medical University of Vienna, Vienna General Hospital, Vienna, Austria.

Technology: Extracorporeal carbon dioxide removal means the removal of carbon dioxide from the blood across a gas exchange membrane without substantially improving oxygenation. Carbon dioxide removal is possible with substantially less extracorporeal blood flow than needed for oxygenation. Techniques for extracorporeal carbon dioxide removal include (1) pumpless arterio-venous circuits, (2) low-flow venovenous circuits based on the technology of continuous renal replacement therapy, and (3) venovenous circuits based on extracorporeal membrane oxygenation technology. Read More

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http://dx.doi.org/10.1177/0267659120906048DOI Listing