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    [Clinical Analysis of 10 Cases of B Cell Lymphoma-Associated Hemophagocytic Syndrome].
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 2017 Aug;25(4):1022-1029
    Department of Hematology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China.
    Objective: To investigate the clinical and laboratory features of patient with B cell lymphoma associated hemophagocytic syndrome(B-LAHS).

    Methods: The clinical data of 10 cases of B-LAHS were retrospectively analysed and the relevant literatures were reviewed.

    Results: The median age of 10 cases diagnosed as B-LAHS was 55. Read More

    Physiologic Features of Brain Death.
    Am Surg 2017 Aug;83(8):850-854
    Brain death is known to be associated with physiologic derangements but their incidence is poorly described. Knowledge of the changes that occur during brain death is important for management of the potential organ donor. Thus, we sought to characterize the pathophysiology that occurs during brain death in patients with traumatic injuries. Read More

    Successful Resuscitation of a Patient with Life-Threatening Metabolic Acidosis by Hemodialysis: A Case of Ethylene Glycol Intoxication.
    Case Rep Nephrol 2017 25;2017:9529028. Epub 2017 Jul 25.
    Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
    Background: Ethylene glycol intoxication causes severe metabolic acidosis and acute kidney injury. Fomepizole has become available as its antidote. Nevertheless, a prompt diagnosis is not easy because patients are often unconscious. Read More

    Combined Respiratory Chain Deficiency and UQCC2 Mutations in Neonatal Encephalomyopathy: Defective Supercomplex Assembly in Complex III Deficiencies.
    Oxid Med Cell Longev 2017 19;2017:7202589. Epub 2017 Jul 19.
    Department of Pediatrics, Salzburger Landeskliniken (SALK) and Paracelsus Medical University (PMU), 5020 Salzburg, Austria.
    Vertebrate respiratory chain complex III consists of eleven subunits. Mutations in five subunits either mitochondrial (MT-CYB) or nuclear (CYC1, UQCRC2, UQCRB, and UQCRQ) encoded have been reported. Defects in five further factors for assembly (TTC19, UQCC2, and UQCC3) or iron-sulphur cluster loading (BCS1L and LYRM7) cause complex III deficiency. Read More

    Practical approach to the patient with acute neuromuscular weakness.
    World J Clin Cases 2017 Jul;5(7):270-279
    Rajeev Nayak, Department of Neurology, Jabalpur Hospital and Research Centre, Jabalpur 482002, Madhyapradesh, India.
    Acute neuromuscular paralysis (ANMP) is a clinical syndrome characterized by rapid onset muscle weakness progressing to maximum severity within several days to weeks (less than 4 wk). Bulbar and respiratory muscle weakness may or may not be present. It is a common neurological emergency which requires immediate and careful investigations to determine the etiology because accurate diagnosis has significant impact on therapy and prognosis. Read More

    Effect of sodium bicarbonate on prolonged running performance: A randomized, double-blind, cross-over study.
    PLoS One 2017 10;12(8):e0182158. Epub 2017 Aug 10.
    Institute of Sports and Preventive Medicine, Saarland University, Saarbrücken, Germany.
    Background: The ability to sustain intense exercise seems to be partially limited by the body's capability to counteract decreases in both intra- and extracellular pH. While the influence of an enhanced buffering capacity via sodium bicarbonate (BICA) on short-term, high-intensity exercise performance has been repeatedly investigated, studies on prolonged endurance performances are comparatively rare, especially for running. The aim of the following study was to assess the ergogenic effects of an oral BICA substitution upon exhaustive intensive endurance running performance. Read More

    Synthetic cannabinoid induced acute respiratory depression: Case series and literature review.
    Respir Med Case Rep 2017 29;22:137-141. Epub 2017 Jul 29.
    Department of Internal Medicine, Division of Pulmonary Medicine and Critical Care Medicine, New York City Health+Hospitals Harlem, Columbia University College of Physicians and Surgeons, New York, NY, USA.
    Synthetic Cannabinoids are a street drug that is widely attainable and cheap compared to natural cannabis, and has variable potency and unpredictable effects with no commercially available diagnostic test to confirm its presence. Similar to natural cannabis, Synthetic Cannabinoid intoxication can present in several ways with the most common emergency room presentations to be of neurologic and psychiatric manifestation. The respiratory depressive effect of Synthetic Cannabinoids has not been well documented in medical literature. Read More

    Oral pyridoxine can substitute for intravenous pyridoxine in managing patients with severe poisoning with isoniazid and rifampicin fixed dose combination tablets: a case report.
    BMC Res Notes 2017 Aug 8;10(1):370. Epub 2017 Aug 8.
    University Medical Unit, National Hospital of Sri Lanka, Colombo 10, Sri Lanka.
    Background: Fixed drug combination of isoniazid and rifampicin is a rare cause of poisoning even in endemic countries for tuberculosis infection. Severe poisoning can cause severe morbidity and mortality if not treated promptly. Though intravenous pyridoxine is the preferred antidote for severe standard isoniazid poisoning it is not freely available even in best of care centers. Read More

    Atropine use may lead to post-operative respiratory acidosis in neonates receiving ductal ligation: A retrospective cohort study.
    Pediatr Neonatol 2017 Jul 20. Epub 2017 Jul 20.
    Department of Pediatrics, MacKay Children's Hospital, Taipei 10449, Taiwan; Department of Medicine, MacKay Medical College, New Taipei City 252, Taiwan. Electronic address:
    Background: Patent ductus arteriosus (PDA) is one of the most common cardiac conditions in preterm infants. Closure of the PDA in symptomatic patients can be achieved medically or surgically. Atropine is commonly administered in general anesthesia as a premedication in this age group but with limited evidence addressing the effect of its use. Read More

    Severe pulmonary edema following hyperbaric oxygen therapy for acute carbon monoxide poisoning: a case report and clinical experience.
    Undersea Hyperb Med 2017 May-Jun;44(3):287-291
    Department of Hyperbaric Oxygen, Navy General Hospital, PR China.
    Purpose: Pulmonary edema following hyperbaric oxygen (HBO₂) therapy is a rare clinical phenomenon. This case report describes such a patient - a 56-year-old woman who suffered from severe pulmonary edema after HBO₂ therapy for carbon monoxide (CO) poisoning.

    Case: Patient experienced ecphysesis and dyspnea suddenly after HBO₂ therapy (100% oxygen at 0. Read More

    Impact of membrane lung surface area and blood flow on extracorporeal CO2 removal during severe respiratory acidosis.
    Intensive Care Med Exp 2017 Dec 1;5(1):34. Epub 2017 Aug 1.
    Department of Pneumology and Critical Care Medicine, Cologne-Merheim Hospital, ARDS and ECMO Centre, Kliniken der Stadt Köln gGmbH, Witten/Herdecke University Hospital, Ostmerheimer Strasse 200, D-51109, Cologne, Germany.
    Background: Veno-venous extracorporeal CO2 removal (vv-ECCO2R) is increasingly being used in the setting of acute respiratory failure. Blood flow rates through the device range from 200 ml/min to more than 1500 ml/min, and the membrane surface areas range from 0.35 to 1. Read More

    Migraine in mitochondrial disorders: Prevalence and characteristics.
    Cephalalgia 2017 Jan 1:333102417723568. Epub 2017 Jan 1.
    1 Unità di Neurofisiopatologia, Area Neuroscienze, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.
    Background Migraine is a well-known feature of mitochondrial disorders (MDs). However, no systematic epidemiological data are available in large populations of patients. Aims The aim of this cross-sectional cohort study was to describe the prevalence and migraine characteristics in a large cohort of patients with mitochondrial encephalomyopathies. Read More

    Therapeutic hypothermia brings favorable neurologic outcomes in children with near drowning.
    Ci Ji Yi Xue Za Zhi 2016 Oct-Dec;28(4):180-182. Epub 2016 Sep 15.
    Department of Pediatrics, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
    A 1-year-10-month-old boy was admitted to our pediatric intensive care unit due to near drowning with pulmonary edema. A conventional ventilator with 100% oxygen supplementation was used initially, but was shifted to high frequency oscillatory ventilation as his oxygen saturation was around 84-88%. Therapeutic hypothermia was applied due to hypoxic ischemic encephalopathy with severe acidosis. Read More

    Carbon dioxide narcosis due to inappropriate oxygen delivery: a case report.
    J Med Case Rep 2017 Jul 28;11(1):204. Epub 2017 Jul 28.
    University of Bern, Medical Faculty, Bern, Switzerland.
    Background: Oxygen delivery to patients with chronic obstructive pulmonary disease may be challenging because of their potential hypoxic ventilatory drive. However, some oxygen delivery systems such as non-rebreathing face masks with an oxygen reservoir bag require high oxygen flow for adequate oxygenation and to avoid carbon dioxide rebreathing.

    Case Presentation: A 72-year-old Caucasian man with severe chronic obstructive pulmonary disease was admitted to the emergency department because of worsening dyspnea and an oxygen saturation of 81% measured by pulse oximetry. Read More

    Two Cases of Pneumatosis Cystoides Intestinalis With Intraperitoneal Free Air.
    Gastroenterology Res 2017 Jun 30;10(3):208-211. Epub 2017 Jun 30.
    Department of Internal Medicine, Kawasaki Hospital, Kobe, Japan.
    Intraperitoneal free air (IFA) is sometimes accompanied by pneumatosis cystoides intestinalis (PCI); therefore, proper diagnosis is essential for PCI management. We report two cases of PCI with IFA. A 70-year-old female taking anti-psychotic medication for schizophrenia presented with repeated vomiting and high-grade fever. Read More

    Minimum Alveolar Concentration and Cardiopulmonary Effects of Isoflurane in Ring-tailed Lemurs (Lemur catta).
    J Am Assoc Lab Anim Sci 2017 Jul;56(4):452-456
    Duke Lemur Center, Duke University, Durham, North Carolina.
    The goal of this study was to determine the minimum alveolar concentration (MAC) and cardiopulmonary effects of isoflurane in ring-tailed lemurs (Lemur catta). The MAC of isoflurane was determined by using a tail-clamp stimulus in adult ring-tailed lemurs (6 male, 4 female). Once MAC was determined, another group of 10 adult ring-tailed lemurs (5 male, 5 female) were anesthetized and instrumented similarly as the previous group and maintained at 0. Read More

    [Disorders of water and electrolyte metabolism and changes in acid-base balance in patients with ascitic liver cirrhosis].
    Cas Lek Cesk 2017 ;156(3):150-152
    In patients with advanced cirrhosis with ascites disorders of water and electrolyte metabolism are often present and they are associated with changes in acid-base balance. These changes can be very complicated, their diagnosis and treatment difficult. Dilutional hyponatremia is the most common disorder. Read More

    Current perspectives for the use of gonane progesteronergic drugs in the treatment of central hypoventilation syndromes.
    Curr Neuropharmacol 2017 Jul 19. Epub 2017 Jul 19.
    Sorbonne Universités, UPMC Univ. Paris 06, INSERM, UMR_S1158 Neurophysiologie Respiratoire Expérimentale et Clinique, F-75013, Paris. France.
    Background: Central alveolar hypoventilation syndromes (CHS) encompass neurorespiratory diseases resulting from congenital or acquired neurological disorders. Hypercapnia, acidosis, and hypoxemia resulting from CHS negatively affect physiological functions and can be life-threatening. To date, the absence of pharmacological treatment implies that the patients must receive assisted ventilation throughout their lives. Read More

    Acute Alcohol Binge Deteriorates Metabolic and Respiratory Compensation Capability After Blunt Chest Trauma Followed by Hemorrhagic Shock-A New Research Model.
    Alcohol Clin Exp Res 2017 Jul 17. Epub 2017 Jul 17.
    Department of Trauma, Hand and Reconstructive Surgery, University Hospital Frankfurt, Goethe-University, Frankfurt am Main, Germany.
    Background: The clinical relevance of blunt (thoracic) chest trauma (TxT) and hemorrhagic shock is indisputable due to the high prevalence of this injury type, as well as its close association with mortality and/or preventable deaths. Furthermore, there is an ongoing discussion about the influence of alcohol in trauma patients. Thus, we established a model of TxT followed by hemorrhagic shock with resuscitation (H/R) in alcohol-intoxicated rats. Read More

    [Update: acute hypercapnic respiratory failure].
    Med Klin Intensivmed Notfmed 2017 Jul 13. Epub 2017 Jul 13.
    Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Klinikum Kassel GmbH, 34125, Kassel, Deutschland.
    Background: Hypercapnic respiratory failure is a frequent problem in critical care and mainly affects patients with acute exacerbation of COPD (AECOPD) and acute respiratory distress syndrome (ARDS). In recent years, the usage of extracorporeal CO2 removal (ECCO2R) has been increasing.

    Objective: Summarizing the state of the art in the management of hypercapnic respiratory failure with special regard to the role of ECCO2R. Read More

    Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease.
    Cochrane Database Syst Rev 2017 Jul 13;7:CD004104. Epub 2017 Jul 13.
    Department of Physiotherapy, Monash University, McMahons Road, Frankston, Melbourne, Victoria, Australia, 3199.
    Background: Non-invasive ventilation (NIV) with bi-level positive airway pressure (BiPAP) is commonly used to treat patients admitted to hospital with acute hypercapnic respiratory failure (AHRF) secondary to an acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

    Objectives: To compare the efficacy of NIV applied in conjunction with usual care versus usual care involving no mechanical ventilation alone in adults with AHRF due to AECOPD. The aim of this review is to update the evidence base with the goals of supporting clinical practice and providing recommendations for future evaluation and research. Read More

    Acid-base disorders in liver disease.
    J Hepatol 2017 Jul 3. Epub 2017 Jul 3.
    Department of Respiratory and Critical Care Medicine, Otto Wagner Spital, Vienna, Austria. Electronic address:
    Next to the kidneys and lungs, the liver has been recognized as an important regulator of acid-base homeostasis. While respiratory alkalosis is the most common acid-base disorder in chronic liver disease, various complex metabolic acid-base disorders may occur with liver dysfunction. Although the standard variables of acid-base equilibrium, such as pH and overall base excess, often fail to unmask the underlying cause of acid-base disorders, the physical-chemical acid-base model allows a more in-depth pathophysiological understanding and clinical judgement of acid-base disorders in patients with liver diseases. Read More

    The metabolic effects of diuron in the rat liver.
    Environ Toxicol Pharmacol 2017 Sep 27;54:53-61. Epub 2017 Jun 27.
    Department of Biochemistry, Maringá University, 87020900 Maringá, Brazil. Electronic address:
    A systematic study on the effects of diuron on the hepatic metabolism was conducted with emphasis on parameters linked to energy metabolism. The experimental system was the isolated perfused rat liver. The results demonstrate that diuron inhibited biosynthesis (gluconeogenesis) and ammonia detoxification, which are dependent of ATP generated within the mitochondria. Read More

    Review of Evidence for Adult Diabetic Ketoacidosis Management Protocols.
    Front Endocrinol (Lausanne) 2017 13;8:106. Epub 2017 Jun 13.
    Department of Endocrinology, Austin Health, Melbourne, VIC, Australia.
    Background: Diabetic ketoacidosis (DKA) is an endocrine emergency with associated risk of morbidity and mortality. Despite this, DKA management lacks strong evidence due to the absence of large randomised controlled trials (RCTs).

    Objective: To review existing studies investigating inpatient DKA management in adults, focusing on intravenous (IV) fluids; insulin administration; potassium, bicarbonate, and phosphate replacement; and DKA management protocols and impact of DKA resolution rates on outcomes. Read More

    Assessing Passeriformes health in South Texas via select venous analytes.
    Comp Biochem Physiol B Biochem Mol Biol 2017 Aug 17;210:64-71. Epub 2017 Jun 17.
    Department of Wildlife & Fisheries Sciences, Texas A&M University, 210 Nagle Hall, 2258 TAMU, College Station, TX 77843, USA.
    The handheld point of care analyzer is a quick and feasible option to obtain hematology data from individuals. The iSTAT-1® was used to evaluate select venous blood analytes obtained via jugular venipuncture from 238 passerine birds from South Texas. These data were used to assess the health of birds in the area while taking into consideration life history (migratory or sedentary), locale, seasonality, sex, and age. Read More

    Pseudo-thrombotic thrombocytopenic purpura presenting as multi-organ dysfunction syndrome: A rare complication of pernicious anemia.
    SAGE Open Med Case Rep 2017 6;5:2050313X17713149. Epub 2017 Jun 6.
    Interfaith Medical Center, Brooklyn, NY, USA.
    Objective: We present a rare case of pernicious anemia presented as multi-organ dysfunction syndrome, later found to have pseudo-thrombotic thrombocytopenic purpura.

    Methods: An 86-year-old female presented with respiratory distress, altered mental status, acute renal failure and was intubated in emergency room. She was found to have severe anemia, thrombocytopenia, high lactate, high lactate dehydrogenase and low haptoglobin. Read More

    Hypercapnia Accelerates Adipogenesis: A Novel Role of High CO2 in Exacerbating Obesity.
    Am J Respir Cell Mol Biol 2017 Jun 14. Epub 2017 Jun 14.
    Tokyo Medical University Ibaraki Medical Center , Department of Respiratory Medicine, Ibaraki, Japan ;
    Obesity is a major risk factor for the development of obstructive sleep apnea (OSA) and obesity hypoventilation syndrome (OHS), which manifest as intermittent hypercapnia and sustained plus intermittent hypercapnia, respectively. In this study, we investigated whether CO2 affects adipocyte differentiation (adipogenesis) and maturation (hypertrophy). Human visceral or subcutaneous preadipocytes were grown to confluence and then induced to differentiate to adipocytes under hypocapnia, normocapnia, and hypercapnia with or without hypoxia. Read More

    Postoperative Compensatory Ammonium Excretion Subsequent to Systemic Acidosis in Cardiac Patients.
    Biomed Res Int 2017 22;2017:5383574. Epub 2017 May 22.
    Institute of Physiological Chemistry, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, Essen, 45147 North Rhine-Westphalia, Germany.
    Background: Postoperative acid-base imbalances, usually acidosis, frequently occur after cardiac surgery. In most cases, the human body, not suffering from any severe preexisting illnesses regarding lung, liver, and kidney, is capable of transient compensation and final correction. The aim of this study was to correlate the appearance of postoperatively occurring acidosis with renal ammonium excretion. Read More

    Water, electrolyte, acid-base, and trace elements alterations in cirrhotic patients.
    Int Urol Nephrol 2017 Jun 12. Epub 2017 Jun 12.
    Department of Medicine, Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
    Chronic hepatic patients, and particularly those suffering from cirrhosis, are predisposed to different sort of water, electrolyte, acid-base, and trace elements disorders due to their altered liver function, and also to their exposition to infectious, inflammatory, oncologic, and pharmacologic variables whose combination undermines their homeostatic capability. Hyponatremia, hypokalemia, hyperkalemia, hypocalcemia, metabolic acidosis, respiratory, and metabolic alkalosis are the main internal milieu alterations in this group. Read More

    Metabolic Acidosis or Respiratory Alkalosis? Evaluation of a Low Plasma Bicarbonate Using the Urine Anion Gap.
    Am J Kidney Dis 2017 Jun 6. Epub 2017 Jun 6.
    Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, CT.
    Hypobicarbonatemia, or a reduced bicarbonate concentration in plasma, is a finding seen in 3 acid-base disorders: metabolic acidosis, chronic respiratory alkalosis and mixed metabolic acidosis and chronic respiratory alkalosis. Hypobicarbonatemia due to chronic respiratory alkalosis is often misdiagnosed as a metabolic acidosis and mistreated with the administration of alkali therapy. Proper diagnosis of the cause of hypobicarbonatemia requires integration of the laboratory values, arterial blood gas, and clinical history. Read More

    Compound heterozygous mutations in glycyl-tRNA synthetase (GARS) cause mitochondrial respiratory chain dysfunction.
    PLoS One 2017 8;12(6):e0178125. Epub 2017 Jun 8.
    Genetic Metabolic Disorders Research Unit, Western Sydney Genetics Program, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
    Glycyl-tRNA synthetase (GARS; OMIM 600287) is one of thirty-seven tRNA-synthetase genes that catalyses the synthesis of glycyl-tRNA, which is required to insert glycine into proteins within the cytosol and mitochondria. To date, eighteen mutations in GARS have been reported in patients with autosomal-dominant Charcot-Marie-Tooth disease type 2D (CMT2D; OMIM 601472), and/or distal spinal muscular atrophy type V (dSMA-V; OMIM 600794). In this study, we report a patient with clinical and biochemical features suggestive of a mitochondrial respiratory chain (MRC) disorder including mild left ventricular posterior wall hypertrophy, exercise intolerance, and lactic acidosis. Read More

    Hyperlactetemia And Its Trends In Critically Ill Children Admitted In Pediatric Intensive Care Unit Of A Developing Country.
    J Ayub Med Coll Abbottabad 2016 Oct-Dec;28(4):660-663
    Department Of Paediatrics and Child Health, Aga Khan University Karachi, Pakistan.
    Background: There is increasing evidence that in setting of critical ailments clinical signs lag biomarkers like Lactate and hyperlactetemia can be the only marker for this disorder. This study was conducted to describe the incidence of hyperlactatemia in critically ill children and its association with outcome.

    Methods: Retrospective review of medical records of all children who had their lactic acid (LA) levels measured during their admission in PICU from January 2014 to December 2015 was done. Read More

    Delayed but successful response to noninvasive ventilation in COPD patients with acute hypercapnic respiratory failure.
    Int J Chron Obstruct Pulmon Dis 2017 25;12:1539-1547. Epub 2017 May 25.
    Intensive Care Unit, Arras Hospital, Arras.
    Background: We evaluated a new noninvasive ventilation (NIV) protocol that allows the pursuit of NIV in the case of persistent severe respiratory acidosis despite a first NIV challenge in COPD patients with acute hypercapnic respiratory failure (AHRF).

    Patients And Methods: A prospective observational multicentric pilot study was conducted in three tertiary hospitals over a 12-month study period. A total of 155 consecutive COPD patients who were admitted for AHRF and treated by NIV were enrolled. Read More

    Gelsemium elegans Poisoning: A Case with 8 Months of Follow-up and Review of the Literature.
    Front Neurol 2017 17;8:204. Epub 2017 May 17.
    Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
    Background: Gelsemium elegans (G. elegans) is a toxic plant indigenous to Southeast Asia. It is highly poisonous due to its strong respiratory depressive effect. Read More

    Metabolic acidosis as a risk factor for the development of acute kidney injury and hospital mortality.
    Exp Ther Med 2017 May 30;13(5):2362-2374. Epub 2017 Mar 30.
    Division of Nephrology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China.
    Metabolic acidosis has been proved to be a risk factor for the progression of chronic kidney disease, but its relation to acute kidney injury (AKI) has not been investigated. In general, a diagnosis of metabolic acidosis is based on arterial blood gas (ABG) analysis, but the diagnostic role of carbon dioxide combining power (CO2CP) in the venous blood may also be valuable to non-respiratory patients. This retrospective study included all adult non-respiratory patients admitted consecutively to our hospital between October 01, 2014 and September 30, 2015. Read More

    Radiographic assessment of pulmonary fluid clearance and lung aeration in newborn calves delivered by elective Caesarean section.
    Reprod Domest Anim 2017 May 30. Epub 2017 May 30.
    Faculty of Veterinary Science, Clinic for Large Animals, Szent István University, Üllő - Dóra major, Hungary.
    The aim of this study was to develop a radiographic standard for the assessment of pulmonary fluid clearance and lung aeration in newborn calves. Caesarean-delivered mature calves (n = 9) underwent lung assessment by thoracic radiography as well as arterial and venous blood gas analysis within the first 30 min, 1, 2, 3, 6, 12 and 24 hr after birth. The results indicated that newborn calves delivered by elective Caesarean section suffered from a physiological combined respiratory and metabolic acidosis with the dominance of respiratory acidosis, and an improvement in these conditions was recorded within 24 hr after birth. Read More

    Combination Clearance Therapy and Barbiturate Coma for Severe Carbamazepine Overdose.
    Pediatrics 2017 May;139(5)
    Divisions of Medicine Critical Care,
    A 15-year-old female subject presented comatose, in respiratory failure and shock, after the intentional ingestion of ∼280 extended-release 200-mg carbamazepine tablets with a peak serum concentration of 138 µg/mL (583.74 µmol/L). The patient developed clinical seizures and an EEG pattern of stimulus-induced rhythmic, periodic, or ictal discharges, suggestive of significant cortical dysfunction. Read More

    Physiological implications of ocean acidification for marine fish: emerging patterns and new insights.
    J Comp Physiol B 2017 May 25. Epub 2017 May 25.
    Marine Science Institute, University of Texas at Austin, Austin, TX, 78373, USA.
    Ocean acidification (OA) is an impending environmental stress facing all marine life, and as such has been a topic of intense research interest in recent years. Numerous detrimental effects have been documented in marine fish, ranging from reduced mortality to neurosensory impairment, and the prevailing opinions state that these effects are largely the downstream consequences of altered blood carbon dioxide chemistry caused by respiratory acid-base disturbances. While the respiratory acid-base disturbances are consistent responses to OA across tested fish species, it is becoming increasingly clear that there is wide variability in the degree of downstream impairments between species. Read More

    Green discolouration of urine following propofol infusion in a dog.
    J Small Anim Pract 2017 May 25. Epub 2017 May 25.
    Division of Small Animal Clinical Sciences, Institute of Comparative Medicine, School of Veterinary Medicine, University of Glasgow, Bearsden, Glasgow, G61 1QH, UK.
    A three-year-old, female neutered Weimaraner was presented with a history of neck pain and tetraparesis. MRI revealed an extradural mass at the level of C3 vertebra, which was thought to be a spinal abscess, and the dog was scheduled for surgical exploration the following morning. Overnight the dog developed an exaggerated ventilatory pattern, with paradoxical inward movement of the thorax on inspiration. Read More

    Clinicopathological spectrum of snake bite-induced acute kidney injury from India.
    World J Nephrol 2017 May;6(3):150-161
    Sanjay Vikrant, Ajay Jaryal, Department of Nephrology, Indira Gandhi Medical College, Himachal Pradesh, Shimla 171001, India.
    Aim: To study the clinico-pathological spectrum of snake bite-induced acute kidney injury (AKI).

    Methods: A retrospective study of patients admitted at Indira Gandhi Medical College Hospital, Shimla with snake bite-induced AKI from July 2003 to June 2016. Medical records were evaluated for patient's information on demographic, clinical characteristics, complications and outcome. Read More

    Linezolid-induced lactic acidosis: the thin line between bacterial and mitochondrial ribosomes.
    Expert Opin Drug Saf 2017 Jul 1;16(7):833-843. Epub 2017 Jun 1.
    a Dipartimento di Anestesia, Rianimazione ed Emergenza-Urgenza , Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico , Milan , Italy.
    Introduction: Linezolid inhibits bacterial growth by targeting bacterial ribosomes and by interfering with bacterial protein synthesis. Lactic acidosis is a rare, but potentially lethal, side effect of linezolid. Areas covered: The pathogenesis of linezolid-induced lactic acidosis is reviewed with special emphasis on aspects relevant to the recognition, prevention and treatment of the syndrome. Read More

    Nasal high flow in management of children with status asthmaticus: a retrospective observational study.
    Ann Intensive Care 2017 Dec 22;7(1):55. Epub 2017 May 22.
    Réanimation pédiatrique, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 69500, Bron, France.
    Background: Asthma is the most common obstructive airway disease in children and adults. Nasal high flow (NHF) is a recent device that is now used as a primary support for respiratory distress. Several studies have reported use of NHF as a respiratory support in status asthmaticus; however, there are no data to recommend such practice. Read More

    [Procedural analysis of acid-base balance disorder: case serials in 4 patents].
    Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2017 May;29(5):436-441
    Department of Nephrology, Shuyang People's Hospital, Suqian 223600, Jiangsu, China (Ma CY); Teaching Section of Mathematics, China Medical University, Shenyang 110000, Liaoning, China (Wang GJ). Corresponding author: Wang Guijie, Email:
    Objective: To establish the standardization process of acid-base balance analysis, analyze cases of acid-base balance disorder with the aid of acid-base balance coordinate graph.

    Methods: The acid-base balance theory were reviewed systematically on recent research progress, and the important concepts, definitions, formulas, parameters, regularity and inference in the analysis of acid-base balance were studied. The analysis of acid-base balance disordered processes and steps were figured. Read More

    Renal manifestations of primary mitochondrial disorders.
    Biomed Rep 2017 05 12;6(5):487-494. Epub 2017 Apr 12.
    Paulista de Medicina School, Federal University of São Paulo, Primeiro Andar CEP, São Paulo 04039-032, SP, Brazil.
    The aim of the present review was to summarize and discuss previous findings concerning renal manifestations of primary mitochondrial disorders (MIDs). A literature review was performed using frequently used databases. The study identified that primary MIDs frequently present as mitochondrial multiorgan disorder syndrome (MIMODS) at onset or in the later course of the MID. Read More

    One oxygen breath shortened the time to return of spontaneous circulation in severely asphyxiated piglets.
    Acta Paediatr 2017 May 16. Epub 2017 May 16.
    Department of Paediatric Anaesthesia and Intensive Care, Lund University, Skåne University Hospital, Lund, Sweden.
    Aim: Asphyxiated neonates should be resuscitated with air, but it remains unclear if oxygen supplementation is needed in ineffectively ventilated newborn infants. We studied the return of spontaneous circulation (ROSC) with oxygen or air in an experimental model of inadequate ventilation.

    Methods: Asphyxia was induced in 16 newborn piglets until their heart rate was <60 bpm or mean arterial pressure (MAP) <30 mmHg. Read More

    Electrolyte and Acid-Base Disturbances in End-Stage Liver Disease: A Physiopathological Approach.
    Dig Dis Sci 2017 Aug 13;62(8):1855-1871. Epub 2017 May 13.
    Department of Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, 14080, Mexico City, Mexico.
    Electrolyte and acid-base disturbances are frequent in patients with end-stage liver disease; the underlying physiopathological mechanisms are often complex and represent a diagnostic and therapeutic challenge to the physician. Usually, these disorders do not develop in compensated cirrhotic patients, but with the onset of the classic complications of cirrhosis such as ascites, renal failure, spontaneous bacterial peritonitis and variceal bleeding, multiple electrolyte, and acid-base disturbances emerge. Hyponatremia parallels ascites formation and is a well-known trigger of hepatic encephalopathy; its management in this particular population poses a risky challenge due to the high susceptibility of cirrhotic patients to osmotic demyelination. Read More

    Treatment of Persistent Pulmonary Hypertension of the Newborn: Use of Pulmonary Vasodilators in Term Neonates.
    Neonatal Netw 2017 May;36(3):160-168
    Persistent pulmonary hypertension of the newborn (PPHN) represents a challenging condition associated with significant morbidity. A successful transition from intrauterine to extrauterine life is contingent on adequate pulmonary vasodilation. Several pathophysiologies contribute to the failure of this cascade and may result in life-threatening hypoxia and acidosis in the newborn. Read More

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