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    7432 results match your criteria Respiratory Acidosis

    1 OF 149

    Rhabdomyolysis in Stuve-Wiedemann syndrome.
    BMJ Case Rep 2018 Feb 8;2018. Epub 2018 Feb 8.
    Paediatric Department, University Hospital of Wales, Cardiff, UK.
    A 6-month-old male infant with Stuve-Wiedemann syndrome (SWS) presented with an acute respiratory arrest secondary to a rhinovirus respiratory infection from which he was rapidly resuscitated. He developed an acute kidney injury requiring supportive treatment and on day 3 of his illness was noted to have developed severe rhabdomyolysis (creatine kinase level 132 040 U/L (normal <320 U/L)). He was born from consanguineous parents with homozygous mutations in the leukaemia inhibitory factor receptor. Read More

    Pediatric acute respiratory distress syndrome - current views.
    Exp Ther Med 2018 Feb 14;15(2):1775-1780. Epub 2017 Dec 14.
    Department of Neonatology, Xuzhou Chlidren's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
    Acute respiratory distress syndrome (ARDS) mainly involves acute respiratory failure. In addition to this affected patients feel progressive arterial hypoxemia, dyspnea, and a marked increase in the work of breathing. The only clinical solution for the above pathological state is ventilation. Read More

    Extracorporeal carbon dioxide removal in acute exacerbations of chronic obstructive pulmonary disease.
    Ann Transl Med 2018 Jan;6(2):31
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
    Extracorporeal carbon dioxide removal (ECCOR) has been proposed as an adjunctive intervention to avoid worsening respiratory acidosis, thereby preventing or shortening the duration of invasive mechanical ventilation (IMV) in patients with exacerbation of chronic obstructive pulmonary disease (COPD). This review will present a comprehensive summary of the pathophysiological rationale and clinical evidence of ECCOR in patients suffering from severe COPD exacerbations. Read More

    NDUFB8 Mutations Cause Mitochondrial Complex I Deficiency in Individuals with Leigh-like Encephalomyopathy.
    Am J Hum Genet 2018 Feb 1. Epub 2018 Feb 1.
    Department of Pediatrics, Salzburger Landeskliniken and Paracelsus Medical University Salzburg, 5020 Salzburg, Austria. Electronic address:
    Respiratory chain complex I deficiency is the most frequently identified biochemical defect in childhood mitochondrial diseases. Clinical symptoms range from fatal infantile lactic acidosis to Leigh syndrome and other encephalomyopathies or cardiomyopathies. To date, disease-causing variants in genes coding for 27 complex I subunits, including 7 mitochondrial DNA genes, and in 11 genes encoding complex I assembly factors have been reported. Read More

    Challenges in the diagnosis of acute cyanide poisoning.
    Clin Toxicol (Phila) 2018 Feb 8:1-9. Epub 2018 Feb 8.
    a Division of Medical Toxicology, Department of Emergency Medicine , University of Virginia School of Medicine , Charlottesville , VA , USA.
    Objective: The aim of this systematic review was to identify isolated acute cyanide poison cases and to identify reported signs, symptoms, and laboratory findings.

    Methods: We searched MEDLINE, Cochrane Reviews, and Web of Science case reports and series using a number of MeSH descriptors pertaining to cyanide, toxicity, and poisonings. We excluded studies on plants, laboratory analyses, smoke inhalation poisonings, animals as well as non-English language articles and those in which data were not available. Read More

    Normal saline versus a balanced crystalloid for goal-directed perioperative fluid therapy in major abdominal surgery: a double-blind randomised controlled study.
    Br J Anaesth 2018 Feb 2;120(2):274-283. Epub 2017 Dec 2.
    Department of General Internal Medicine & Emergency Medicine, Hirslanden Klinik im Park, Zurich, Switzerland.
    Background: This double-blind randomised controlled trial investigated whether normal saline or a balanced crystalloid has distinct effects on vasopressor use in patients undergoing major abdominal surgery.

    Methods: Patients received either normal saline 0.9% or an acetate-buffered crystalloid for intraoperative volume replacement in a goal-directed fashion. Read More

    [Severe lactic acidosis requiring continuos haemodiafiltration in a young patient with unrecognized metabolic abnormality. Case report].
    G Ital Nefrol 2018 Feb;35(1)
    S.S. Nefrologia e Dialisi, Ospedale E. Agnelli, Pinerolo, Turin, ASL TO3.
    Background: Lactic acidosis (LA) is the most common form of metabolic acidosis, defined by lactate values greater than 5 mmol/L and pH<7.34. The pathogenesis of LA involves hypoxic causes (type A) and non-hypoxic (type B), often coexisting. Read More

    Home Non-Invasive Ventilation for COPD: How, Who and When?
    Arch Bronconeumol 2018 Jan 19. Epub 2018 Jan 19.
    Lane Fox Respiratory Unit, St Thomas' Hospital, London.
    Patients with chronic obstructive pulmonary disease (COPD) and chronic respiratory failure have high levels of morbidity and mortality. The clinical efficacy of long term home oxygen therapy has been well documented in this patient group but despite the efficacy of non-invasive ventilation (NIV) during acute decompensated respiratory failure the addition of home NIV has been associated with equivocal results. The physiological efficacy of home NIV to improve gas exchange in chronic stable hypercapnic respiratory failure has been proven in small studies but larger clinical trials failed to translate this into clinical efficacy. Read More

    The effects of elevated environmental COon nitrite uptake in the air-breathing clown knifefish, Chitala ornata.
    Aquat Toxicol 2018 Mar 31;196:124-131. Epub 2018 Jan 31.
    Zoophysiology, Department of Bioscience, Aarhus University, Building 1131 C.F. Møllers Allé 3, DK-8000 Aarhus C., Denmark. Electronic address:
    Nitrite and carbon dioxide are common environmental contaminants in the intensive aquaculture ponds used to farm clown knifefish (Chitala ornata) in the Mekong delta, Vietnam. Here we tested the hypothesis that hypercapnia reduces nitrite uptake across the gills, because pH regulation will reduce chloride uptake and hence nitrite uptake as the two ions compete for the same transport route via the branchial HCO/Clexchanger. Fish fitted with arterial catheters were exposed to normocapnic/normoxic water (control), nitrite (1 mM), hypercapnia (21 mmHg CO), or combined hypercapnia (acclimated hypercapnia) and nitrite for 96 h. Read More

    Ammonia excretion and acid-base regulation in the American horseshoe crab,.
    J Exp Biol 2018 Jan 18. Epub 2018 Jan 18.
    Department of Biological Sciences, University of Manitoba, Winnipeg, Canada
    Many studies have investigated ammonia excretion and acid-base regulation in aquatic arthropods, yet current knowledge of marine chelicerates is non-existent. In American horseshoe crabs (), book gills bear physiologically distinct regions: dorsal and ventral half-lamellae, and central mitochondria-rich (CMRA) and peripheral mitochondria-poor areas (PMPA). CMRA and ventral half-lamella exhibited characteristics important to ammonia excretion and/or acid-base regulation as supported by high expression levels of Rhesus-protein 1 (LpRh-1), cytoplasmic carbonic anhydrase (CA-2), and hyperpolarization-activated cyclic nucleotide-gated Kchannel (HCN) compared to PMPA and dorsal half-lamella. Read More

    Deficiency of Carbonic Anhydrase II Results in a Urinary Concentrating Defect.
    Front Physiol 2017 5;8:1108. Epub 2018 Jan 5.
    Department of Physiology, University of Alberta, Edmonton, AB, Canada.
    Carbonic anhydrase II (CAII) is expressed along the nephron where it interacts with a number of transport proteins augmenting their activity. Aquaporin-1 (AQP1) interacts with CAII to increase water flux through the water channel. Both CAII and aquaporin-1 are expressed in the thin descending limb (TDL); however, the physiological role of a CAII-AQP1 interaction in this nephron segment is not known. Read More

    New Findings on the Pathogenesis of Distal Renal Tubular Acidosis.
    Kidney Dis (Basel) 2017 Dec 24;3(3):98-105. Epub 2017 Aug 24.
    Department of Cardiothoracic and Respiratory Science, University of Campania "Luigi Vanvitelli," Naples, Italy.
    Background: Distal renal tubular acidosis (dRTA) is characterized by an impairment of the urinary acidification process in the distal nephron. Complete or incomplete metabolic acidosis coupled with inappropriately alkaline urine are the hallmarks of this condition. Genetic forms of dRTA are caused by loss of function mutations of either, encoding the AE1 anion exchanger, orand, encoding for the B1 and a4 subunits of the vHATPase, respectively. Read More

    Acute kidney injury due to multiple Hymenoptera stings-a clinicopathological study.
    Clin Kidney J 2017 Aug 28;10(4):532-538. Epub 2017 Mar 28.
    Community Medicine, Indira Gandhi Medial College, Shimla, Himachal Pradesh, India.
    Background: Acute kidney injury (AKI) after multiple Hymenoptera stings is well known but still a rare phenomenon.

    Methods: We conducted a retrospective study of the clinicopathological spectrum of AKI due to multiple Hymenoptera stings over 13 years (July 2003-June 2016).

    Results: A total of 35 patients were diagnosed with AKI due to multiple Hymenoptera stings. Read More

    Acute Cor Pulmonale in Veno-Venous Extracorporeal Membrane Oxygenation: Three Case Reports.
    ASAIO J 2018 Jan 10. Epub 2018 Jan 10.
    A retrospective review of three patients with acute respiratory distress syndrome (ARDS) and normal baseline right ventricular function admitted to the Cardiac Surgery Intensive Care Unit whom developed acute cor pulmonale while on veno-venous extracorporeal membrane oxygenation. These patients were diagnosed with ARDS using Berlin Criteria definitions and cannulated with a dual lumen (Avalon) cannula. Despite variations in history, presentation, and course, findings of acute cor pulmonale were encountered 4 to 6 weeks after extracorporeal membrane oxygenation cannulation. Read More

    [Our experience with chest wall stabilization].
    Rozhl Chir 2017 ;96(11):469-474
    Introduction: An unstable chest wall is defined as a fracture of at least three adjacent ribs broken at least in two planes. As a result of impaired mechanical strength of the chest wall, paradoxical movements occur, resulting in insufficient pulmonary ventilation with the development of respiratory insufficiency with typical consequences - hypoxia, hypercapnia and acidosis.

    Methods: In this paper we describe a group of 16 patients who underwent stabilization of the chest wall. Read More

    The effect of metabolic alkalosis on the ventilatory response in healthy subjects.
    Respir Physiol Neurobiol 2018 Feb 4;249:47-53. Epub 2018 Jan 4.
    Department of Critical Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Intensive Care Medicine, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:
    Background: Patients with acute respiratory failure may develop respiratory acidosis. Metabolic compensation by bicarbonate production or retention results in posthypercapnic alkalosis with an increased arterial bicarbonate concentration. The hypothesis of this study was that elevated plasma bicarbonate levels decrease respiratory drive and minute ventilation. Read More

    Establishment of an Extracellular Acidic pH Culture System.
    J Vis Exp 2017 Nov 19(129). Epub 2017 Nov 19.
    Laboratory for Systems Biology and Medicine, RCAST, The University of Tokyo;
    Conditions of the tumor microenvironment, such as hypoxia or nutrient starvation, play critical roles in cancer progression and malignancy. However, the role of acidic extracellular pH in tumor aggressiveness and its underlying mechanism has not been extensively studied compared to hypoxic or nutrient starvation conditions. In addition, a well-defined culture method to mimic the acidic extracellular tumor microenvironment has not been fully reported. Read More


    Mitochondrial Alterations (Inhibition of Mitochondrial Protein Expression, Oxidative Metabolism and Ultrastructure) Induced by Linezolid and Tedizolid at Clinically-relevant Concentrations in cultured Human HL-60 promyelocytes and THP-1 monocytes.
    Antimicrob Agents Chemother 2017 Dec 20. Epub 2017 Dec 20.
    Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium
    Linezolid, the first clinically-available oxazolidinone antibiotic, causes potentially severe toxicities (myelosuppression, lactic acidosis, neuropathies) ascribed to impairment of mitochondrial protein synthesis and consecutive mitochondrial dysfunction. Tedizolid, a newly approved oxazolidinone, shows an enhanced activity compared to linezolid but is also a more potent inhibitor of mitochondrial protein synthesis. We have compared linezolid and tedizolid for (i) inhibition of the expression of subunit I of cytochrome-oxidase (CYTox I; Western blot analysis); (ii) cytochrome-oxidase activity (biochemical assay), (iii) mitochondrial oxidative metabolism (Seahorse technology), and alteration of mitochondrial ultrastructure (electron microscopy) using HL-60 promyelocytes and THP-1 monocytes exposed to microbiologically (multiples of modal MIC against) and therapeutically (C- C) pertinent concentrations. Read More

    Adult-onset of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome with hypothyroidism and psychiatric disorders.
    eNeurologicalSci 2017 Mar 4;6:16-20. Epub 2016 Nov 4.
    Department of Neurology, Tongji University Affiliated Tenth People's Hospital, 200072 Shanghai, PR China.
    Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) is a clinical syndrome associated with mitochondrial disorders (MIDs). This report illustrates a case of MELAS syndrome with hypothyroidism and psychiatric disorders, which is different from the common clinical manifestations of MELAS syndrome, such as exercise intolerance, migraine-like headaches, hearing loss and seizures etc. There are considerable interests in the possibility that mitochondrial dysfunction may play a role in the pathogenesis of endocrine dysfunctions and psychiatric disorders in MELAS syndrome. Read More

    Umbilical cord milking at birth for term newborns with acidosis: neonatal outcomes.
    J Perinatol 2017 Dec 12. Epub 2017 Dec 12.
    Neonatal Research Institute at Sharp Mary Birch Hospital for Women and Newborns, San Diego, CA, USA.
    Objective: To determine if umbilical cord milking is detrimental in compromised term/near-term infants.

    Study Design: A retrospective analysis of infants with abnormal cord gases (cord arterial or venous pH of ≤ 7.1 or base deficit > -12). Read More

    Models of care for non-invasive ventilation in the Acute COPD Comparison of three Tertiary hospitals (ACT3) study.
    Respirology 2017 Dec 10. Epub 2017 Dec 10.
    Department of Respiratory and Sleep Medicine, Box Hill Hospital, Melbourne, VIC, Australia.
    Background And Objective: Non-invasive ventilation (NIV) improves clinical outcomes in hypercapnic acute exacerbations of COPD (AECOPD), but the optimal model of care remains unknown.

    Methods: We conducted a prospective observational non-inferiority study comparing three models of NIV care: general ward (Ward) (1:4 nurse to patient ratio, thrice weekly consultant ward round), a high dependency unit (HDU) (1:2 ratio, twice daily ward round) and an intensive care unit (ICU) (1:1 ratio, twice daily ward round) model in three similar teaching tertiary hospitals. Changes in arterial blood gases (ABG) and clinical outcomes were compared and corrected for differences in AECOPD severity (Blood urea > 9 mmol/L, Altered mental status (Glasgow coma scale (GCS) < 14), Pulse > 109 bpm, age > 65 (BAP-65)) and co-morbidities. Read More

    Kombucha: is a cup of tea good for you?
    BMJ Case Rep 2017 Dec 2;2017. Epub 2017 Dec 2.
    Department of Respiratory Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
    A 54-year-old asthmatic woman presented to hospital with a 10-day history of breathlessness. On examination, she was tachypnoeic with mild wheeze. She had preserved peak flows and was saturating at 100% on room air. Read More

    Mechanisms of acid-base regulation in peritoneal dialysis.
    Nephrol Dial Transplant 2017 Nov 22. Epub 2017 Nov 22.
    Division of Nephrology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
    Background: Peritoneal dialysis (PD) contributes to restore acid-base homeostasis in patients with end-stage renal disease. The transport pathways for buffers and carbon dioxide (CO2) across the peritoneal membrane remain poorly understood.

    Methods: Combining well-established PD protocols, whole-body plethysmography and renal function studies in mice, we investigated molecular mechanisms of acid-base regulation in PD, including the potential role of the water channel aquaporin-1 (AQP1). Read More

    Cardiopulmonary rehabilitation program impact on prognostic markers in selected patients with resting and exercise-induced ventilatory inefficiency: a clinical trial.
    J Phys Ther Sci 2017 Oct 21;29(10):1803-1810. Epub 2017 Oct 21.
    Physical Therapy Department for Cardiovascular/Respiratory Disorder and Geriatrics, Faculty of Physical Therapy, Cairo University, Egypt.
    [Purpose] Ventilatory limitation is a common problem in patients with chronic heart failure and pulmonary hypertension. Excess ventilation may arise from augmented ventilatory drive, over activity of chemoreceptors and muscle ergoreceptors, or premature onset of lactic acidosis. Exertional dyspnea can cause limitations in the activities of daily living and as a result, reduced quality of life for these patients. Read More

    Salicylate Intoxication in an Infant: A Case Report.
    Drug Saf Case Rep 2017 Nov 27;4(1):23. Epub 2017 Nov 27.
    Intensive Care Unit, Paediatric Department, Hospital of Santa Maria, Lisbon, Portugal.
    In children, the most common cause of an elevated anion gap (AG) with ketonemia, ketonuria, hyperglycemia, and glycosuria is diabetic ketoacidosis. However, when the clinical history is not clear, other causes must be considered. A 9-month-old girl was transferred to our pediatric intensive care unit (PICU) because of severe metabolic acidosis. Read More

    Low flow extracorporeal COremoval in ARDS patients: a prospective short-term crossover pilot study.
    BMC Anesthesiol 2017 Nov 28;17(1):155. Epub 2017 Nov 28.
    Intensive Care Unit, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium.
    Background: Lung protective mechanical ventilation (MV) is the corner stone of therapy for ARDS. However, its use may be limited by respiratory acidosis. This study explored feasibility of, effectiveness and safety of low flow extracorporeal COremoval (ECCOR). Read More

    Lithium increases ammonium excretion leading to altered urinary acid-base buffer composition.
    J Nephrol 2017 Nov 24. Epub 2017 Nov 24.
    Department of Biomedicine, Aarhus University, Aarhus, Denmark.
    Previous reports identify a voltage dependent distal renal tubular acidosis (dRTA) secondary to lithium (Li) salt administration. This was based on the inability of Li-treated patients to increase the urine-blood (U-B) pCOwhen challenged with NaHCOand, the ability of sodium neutral phosphate or NaSOadministration to restore U-B pCOin experimental animal models. The underlying mechanisms for the Li-induced dRTA are still unknown. Read More

    Management of Congenital Heart Disease Associated with Ellis-van Creveld Short-rib Thoracic Dysplasia.
    J Pediatr 2017 Dec;191:145-151
    Clinic for Special Children, Strasburg, PA. Electronic address:
    Objective: To evaluate clinical outcome of patients with Ellis-van Creveld syndrome (EVC) in whom congenital heart disease (CHD) repair was delayed intentionally to reduce the risk of postoperative respiratory morbidity and mortality.

    Study Design: This retrospective review of 51 EVC c.1886+5G>T homozygotes born between 2005 and 2014 focused on 18 subjects who underwent surgery for CHD, subdivided into early (mean, 1. Read More

    Thoracoscopic repair of congenital diaphragmatic hernia, review of the results.
    Minerva Pediatr 2017 Nov 21. Epub 2017 Nov 21.
    Department of Pediatric Surgery, Hospital de Braga, Braga, Portugal.
    Congenital diaphragmatic hernia (CDH) remains one of the major challenges in neonatal surgery. Survival rate has increased in the last decades mainly due to perinatal care and surgical technique improvements. Classically, a laparotomy has been performed after cardiovascular and respiratory stabilization. Read More

    Determinants and Outcome of Metabolic Acidosis in Diarrheal Children Under 5 Years of Age in an Urban Critical Care Ward in Bangladesh.
    Glob Pediatr Health 2017 7;4:2333794X17740223. Epub 2017 Nov 7.
    International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
    We evaluated the independent determinants and outcome of metabolic acidosis in diarrheal children. Children under 5 years of age admitted with diarrhea and severe respiratory distress in the critical care ward at Dhaka Hospital of icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh) from April 2010 to April 2014 who had their reports of arterial blood gas analyses were enrolled in the study. We compared clinical and laboratory characteristics between the study children with (cases = 74) and without metabolic acidosis (controls = 65). Read More

    Incidence and Consequences of Near-Drowning-Related Pneumonia-A Descriptive Series from Martinique, French West Indies.
    Int J Environ Res Public Health 2017 Nov 17;14(11). Epub 2017 Nov 17.
    Intensive Care Unit, University Hospital of Martinique, Fort-de-France, 97261 Martinique, France.
    Drowning represents one major cause of accidental death. Near-drowning patients are exposed to aspiration that may result in pneumonia with life-threatening consequences. We designed this descriptive study to investigate the frequency, nature, and consequences of post-drowning pneumonia. Read More

    Shifting Risks and Conflicting Outcomes-ECMO for Neonates with Congenital Diaphragmatic Hernia in the Modern Era.
    J Pediatr 2017 Nov;190:163-168.e4
    Department of Pediatrics, University of Washington, Seattle, WA.
    Objectives: To update previously described trends for neonates with congenital diaphragmatic hernia (CDH) receiving ECMO with changes in recommendations for care, and to determine how recent advancements in respiratory care have affected this patient population.

    Study Design: This study is a retrospective review of more than 2500 neonates with CDH who received ECMO listed in the Extracorporeal Life Support Organization (ELSO) registry. Cochran-Armitage and multivariate regression analyses were used to analyze changes in the patient population over time and in mortality-related risk factors. Read More

    Hyperacute Hemodynamic Effects of BiPAP Noninvasive Ventilation in Patients With Acute Heart Failure and Left Ventricular Systolic Dysfunction in Emergency Department.
    J Intensive Care Med 2018 Feb 15;33(2):128-133. Epub 2017 Nov 15.
    1 Emergency Department, Ospedali Riuniti University Hospital, Foggia, Italy.
    Background: Acute heart failure (AHF) is one of the leading causes of admission to emergency department (ED); severe hypoxemic AHF may be treated with noninvasive ventilation (NIV). Despite the demonstrated clinical efficacy of NIV in relieving symptoms of AHF, less is known about the hyperacute effects of bilevel positive airway pressure (BiPAP) ventilation on hemodynamics of patients admitted to ED for AHF. We therefore aimed to assess the effect of BiPAP ventilation on principal hemodynamic, respiratory, pulse oximetry, and microcirculation indexes in patients admitted to ED for AHF, needing NIV. Read More

    Intensive care in severe malaria: Report from the task force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine.
    J Crit Care 2018 Feb 8;43:356-360. Epub 2017 Nov 8.
    Department of Critical Care Medicine, Bombay Hospital Institute of Medical Sciences, Mumbai, India. Electronic address:
    Severe malaria is common in tropical countries in Africa, Asia, Oceania and South and Central America. It may also occur in travelers returning from endemic areas. Plasmodium falciparum accounts for most cases, although P vivax is increasingly found to cause severe malaria in Asia. Read More

    Acute Systemic Complications of Convulsive Status Epilepticus-A Systematic Review.
    Crit Care Med 2018 Jan;46(1):138-145
    Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, MD.
    Objectives: Status epilepticus is a neurologic emergency with high morbidity and mortality requiring neurointensive care and treatment of systemic complications. This systematic review compiles the current literature on acute systemic complications of generalized convulsive status epilepticus in adults and their immediate clinical impact along with recommendations for optimal neurointensive care.

    Data Sources: We searched PubMed, Medline, Embase, and the Cochrane library for articles published between 1960 and 2016 and reporting on systemic complications of convulsive status epilepticus. Read More

    Pulseless electrical activity during general anesthesia induction in patients with amyotrophic lateral sclerosis.
    J Dent Anesth Pain Med 2017 Sep 25;17(3):235-240. Epub 2017 Sep 25.
    Department of Anesthesiology, School of Dentistry, Dankook University, Cheonan, Korea.
    Pulseless electrical activity (PEA) is a clinical condition characterized by unresponsiveness and lack of palpable pulse in the presence of organized cardiac electrical activity and is caused by a profound cardiovascular insult (e.g., severe prolonged hypoxia or acidosis, extreme hypovolemia, or flow-restricting pulmonary embolus). Read More

    Quantitative relationships among plasma lactate, inorganic phosphorus, albumin, unmeasured anions and the anion gap in lactic acidosis.
    J Crit Care 2017 Oct 13;44:101-110. Epub 2017 Oct 13.
    Department of Anesthesiology, Kobe University Hospital, Kobe City, Hyogo 650-0017, Japan.
    Background: Quantitative relationships among plasma [Lactate], [Pi], [Albumin], unmeasured anions ([UA]) and the anion gap (AG) in lactic acidosis (LA) are not well defined.

    Methods: A mathematical model featuring compensatory potassium and chloride shifts and respiratory changes in LA demonstrated: (1) AG=[Lactate]+Zp×[Pi]+2.4×[Albumin]+constant1+e, where Zp is a function of pH, and e reflects unmeasured anions and cations plus pH-related variations. Read More

    A novel de novo dominant mutation inassociated with mitochondrial myopathy.
    J Med Genet 2017 Dec 27;54(12):815-824. Epub 2017 Oct 27.
    Molecular Neurogenetics Unit, Foundation IRCCS Neurological Institute Besta, Milan, Italy.
    Background: Hereditary myopathy with lactic acidosis and myopathy with deficiency of succinate dehydrogenase and aconitase are variants of a recessive disorder characterised by childhood-onset early fatigue, dyspnoea and palpitations on trivial exercise. The disease is non-progressive, but life-threatening episodes of widespread weakness, metabolic acidosis and rhabdomyolysis may occur. So far, this disease has been molecularly defined only in Swedish patients, all homozygous for a deep intronic splicing affecting mutation inencoding a scaffold protein for the assembly of iron-sulfur (Fe-S) clusters. Read More

    Effects of lung protective mechanical ventilation associated with permissive respiratory acidosis on regional extra-pulmonary blood flow in experimental ARDS.
    BMC Anesthesiol 2017 Oct 27;17(1):149. Epub 2017 Oct 27.
    Department of Anesthesia and Intensive Care Medicine, University Hospital of Bonn, Bonn, Germany.
    Background: Lung protective mechanical ventilation with limited peak inspiratory pressure has been shown to affect cardiac output in patients with ARDS. However, little is known about the impact of lung protective mechanical ventilation on regional perfusion, especially when associated with moderate permissive respiratory acidosis. We hypothesized that lung protective mechanical ventilation with limited peak inspiratory pressure and moderate respiratory acidosis results in an increased cardiac output but unequal distribution of blood flow to the different organs of pigs with oleic-acid induced ARDS. Read More

    Factors relating caesarean section to persistent pulmonary hypertension of the newborn.
    World J Pediatr 2017 Dec 20;13(6):517-527. Epub 2017 Oct 20.
    Department of Neonatology, Children Hospital of Fudan University, Shanghai, 201102, China.
    Background: Several studies have clearly demonstrated a significantly higher incidence of persistent pulmonary hypertension of the newborn (PPHN) in neonates delivered by caesarean section (CS) compared to those delivered vaginally. The pathophysiological factors underlying the link between CS and PPHN are still poorly understood. In this review, we describe the mechanisms that could explain the association between CS delivery and subsequent PPHN, as well as potential preventive measures. Read More

    Acid-base regulation and sensing: Accelerators and brakes in metabolic regulation of cerebrovascular tone.
    J Cereb Blood Flow Metab 2017 Jan 1:271678X17733868. Epub 2017 Jan 1.
    Department of Biomedicine, Aarhus University, Aarhus, Denmark.
    Metabolic regulation of cerebrovascular tone directs blood flow to areas of increased neuronal activity and during disease states partially compensates for insufficient perfusion by enhancing blood flow in collateral blood vessels. Acid-base disturbances frequently occur as result of enhanced metabolism or insufficient blood supply, but despite definitive evidence that acid-base disturbances alter arterial tone, effects of individual acid-base equivalents and the underlying signaling mechanisms are still being debated. His an important intra- and extracellular messenger that modifies cerebrovascular tone. Read More

    Defective mitochondrial rRNA methyltransferase MRM2 causes MELAS-like clinical syndrome.
    Hum Mol Genet 2017 Nov;26(21):4257-4266
    Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK.
    Defects in nuclear-encoded proteins of the mitochondrial translation machinery cause early-onset and tissue-specific deficiency of one or more OXPHOS complexes. Here, we report a 7-year-old Italian boy with childhood-onset rapidly progressive encephalomyopathy and stroke-like episodes. Multiple OXPHOS defects and decreased mtDNA copy number (40%) were detected in muscle homogenate. Read More

    Acute mitochondrial myopathy with respiratory insufficiency and motor axonal polyneuropathy.
    Int J Neurosci 2018 Mar 16;128(3):231-236. Epub 2017 Oct 16.
    d Department of Neurology , Tongren Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China.
    Background: Mitochondrial myopathies (MMs) are mainly presented with chronic muscle weakness and accompanied with other syndromes. MM with acute respiratory insufficiency is rare.

    Aims: To reveal the clinical, pathological and molecular characteristics of a life-threatening MM. Read More

    How important is the COchemoreflex for the control of breathing? Environmental and evolutionary considerations.
    Comp Biochem Physiol A Mol Integr Physiol 2018 Jan 29;215:6-19. Epub 2017 Sep 29.
    University of Missouri, Columbia, United States. Electronic address:
    Haldane and Priestley (1905) discovered that the ventilatory control system is highly sensitive to CO. This "COchemoreflex" has been interpreted to dominate control of resting arterial PCO/pH (PCO/pH) by monitoring PCO/pHand altering ventilation through negative feedback. However, PCO/pHvaries little in mammals as ventilation tightly couples to metabolic demands, which may minimize chemoreflex control of PCO. Read More

    Pulmonary hemodynamics and alveolar oxygenation in healthy dogs anesthetized with propofol or isoflurane during one-lung ventilation in a closed-thoracic experimental model.
    Am J Vet Res 2017 Oct;78(10):1117-1125
    OBJECTIVE To assess pulmonary hemodynamics and alveolar oxygenation in dogs anesthetized with propofol or isoflurane during one-lung ventilation (OLV) in a closed-thoracic experimental model. ANIMALS 6 healthy Beagles. PROCEDURES Dogs were anesthetized with each of 3 protocols (constant rate IV infusion of propofol [0. Read More

    Biallelic C1QBP Mutations Cause Severe Neonatal-, Childhood-, or Later-Onset Cardiomyopathy Associated with Combined Respiratory-Chain Deficiencies.
    Am J Hum Genet 2017 Oct 21;101(4):525-538. Epub 2017 Sep 21.
    Institute of Human Genetics, Technische Universität München, 81675 Munich, Germany; Institute of Human Genetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany. Electronic address:
    Complement component 1 Q subcomponent-binding protein (C1QBP; also known as p32) is a multi-compartmental protein whose precise function remains unknown. It is an evolutionary conserved multifunctional protein localized primarily in the mitochondrial matrix and has roles in inflammation and infection processes, mitochondrial ribosome biogenesis, and regulation of apoptosis and nuclear transcription. It has an N-terminal mitochondrial targeting peptide that is proteolytically processed after import into the mitochondrial matrix, where it forms a homotrimeric complex organized in a doughnut-shaped structure. Read More

    The Role of Sodium Bicarbonate in the Management of Some Toxic Ingestions.
    Int J Nephrol 2017 8;2017:7831358. Epub 2017 Aug 8.
    Department of Medicine, University of Kentucky College of Medicine, Lexington, KY, USA.
    Adverse reactions to commonly prescribed medications and to substances of abuse may result in severe toxicity associated with increased morbidity and mortality. According to the Center for Disease Control, in 2013, at least 2113 human fatalities attributed to poisonings occurred in the United States of America. In this article, we review the data regarding the impact of systemic sodium bicarbonate administration in the management of certain poisonings including sodium channel blocker toxicities, salicylate overdose, and ingestion of some toxic alcohols and in various pharmacological toxicities. Read More

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