Search our Database of Scientific Publications and Authors

I’m looking for a

    7249 results match your criteria Respiratory Acidosis

    1 OF 145

    Vinculin variant M94I identified in sudden unexplained nocturnal death syndrome decreases cardiac sodium current.
    Sci Rep 2017 Feb 20;7:42953. Epub 2017 Feb 20.
    Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison, WI 53792, USA.
    Sudden unexplained nocturnal death syndrome (SUNDS) remains an autopsy negative disorder with unclear etiology. Vinculin (VCL) was linked to sudden arrhythmia death in VCL knockout mice prior to the appearance of cardiomyopathy. We hypothesized VCL mutations underlie risk for SUNDS. Read More

    The influence of mechanical ventilation on physiological parameters in ball pythons (Python regius).
    Comp Biochem Physiol A Mol Integr Physiol 2017 Feb 10;207:30-35. Epub 2017 Feb 10.
    Centre for Zoo and Wildlife Health, Copenhagen Zoo, Roskildevej 32, 2000 Frederiksberg, Denmark.
    Mechanical ventilation is widely recommended for reptiles during anesthesia, and while it is well-known that their low ectothermic metabolism requires much lower ventilation than in mammals, very little is known about the influence of ventilation protocol on the recovery from anesthesia. Here, 15 ball pythons (Python regius) were induced and maintained with isoflurane for 60min at one of three ventilation protocols (30, 125, or 250mlmin(-1)kg(-1) body mass) while an arterial catheter was inserted, and ventilation was then continued on 100% oxygen at the specified rate until voluntary extubation. Mean arterial blood pressure and heart rate (HR) were measured, and arterial blood samples collected at 60, 80, 180min and 12 and 24h after intubation. Read More

    Dynamics of acid-base and hematological regulation in day 15 chicken embryos (Gallus gallus domesticus) exposed to graded hypercapnia and hypoxia.
    Respir Physiol Neurobiol 2017 Feb 9;239:55-63. Epub 2017 Feb 9.
    Developmental Integrative Biology, Department of Biological Sciences, University of North Texas, 1155 Union Circle #305220, Denton, TX 76203, USA.
    Most experiments examining acid-base regulation of chicken embryos have employed static, single time point measurements rather than dynamic, multiple time point measurements that might reveal additional components of developing acid-base regulation. Thus, we studied blood acid-base balance and hematology of day 15 chicken embryos under 24h exposure to graded hypercapnia (1%-7% CO2) accompanied by graded hypoxia (20% O2 down to 13% O2). Across all hypercapnic/hypoxic environments, respiratory acidosis occurred 2h after exposure in proportion to the magnitude of hypercapnia. Read More

    [Systemic lupus erythematosus presenting as severe alveolar hypoventilation and the shrinking lung syndrome].
    Rev Mal Respir 2017 Feb 8. Epub 2017 Feb 8.
    Service des maladies respiratoires, unité Inserm 903, hôpital Maison-Blanche, CHU de Reims, 45, rue Cognacq-Jay, 51092 Reims cedex, France. Electronic address:
    Introduction: The shrinking lung syndrome (SLS) is a rare complication of systemic lupus erythematosus.

    Case Report: A 69-year-old man presented with exertional dyspnoea, muscle weakness, and weight loss of 15kg in 6months. Pulmonary function tests revealed a restrictive lung disorder, with a dramatic decrease in maximal inspiratory pressure (17% of theoretical value), and alveolar hypoventilation (pH 7. Read More

    Lactic Acidosis with Chloramphenicol Treatment in a Child with Cystic Fibrosis.
    J Popul Ther Clin Pharmacol 2017 Jan 30;24(1):40-45. Epub 2017 Jan 30.
    Department of Pediatrics, University of Montreal.
    Children with cystic fibrosis are commonly colonized with multi-resistant bacteria. In such patients, infectious exacerbation may require salvage therapy with uncommonly used antimicrobials, including chloramphenicol. Chloramphenicol is rarely used nowadays because of the associated severe adverse events. Read More

    Blast-Burn Combined Injury Followed by Immediate Seawater Immersion Induces Hemodynamic Changes and Metabolic Acidosis: An Experimental Study in a Canine Model.
    Clin Lab 2016 Jul;62(7):1193-1199
    Background: Severe burn-blast combined injury often causes systematic dysfunction related to blood coagulation, anticoagulation, and fibrinolysis. However, studies of burn-blast combined injury followed by immersion in seawater are rarely reported.

    Methods: A canine burn-blast combined injury model was established including blast injury caused by explosion immediately followed by burning with gelatinized gasoline flames. Read More

    Pulmonary gas exchange and acid-base status during immobilisation of black rhinoceroses (Diceros bicornis) in Zimbabwe.
    J S Afr Vet Assoc 2016 Dec 2;87(1):e1-e9. Epub 2016 Dec 2.
    Department of Clinical Sciences, Swedish University of Agricultural Sciences.
    When immobilising wildlife, adverse side effects can include hypoxaemia, acidosis and hypertension. Pulmonary gas exchange and acid-base status were evaluated during immobilisation of 25 free-ranging and one boma-held black rhinoceros (Diceros bicornis) in Zimbabwe. The effect of different body positions on arterial oxygenation was evaluated. Read More

    Further delineation of a rare recessive encephalomyopathy linked to mutations in GFER thanks to Data Sharing of whole exome sequencing data.
    Clin Genet 2017 Feb 2. Epub 2017 Feb 2.
    Centre de Génétique et Centre de référence «Anomalies du Développement et Syndromes Malformatifs», Hôpital d'Enfants, Centre Hospitalier Universitaire de Dijon, Dijon, France.
    Alterations in GFER gene have been associated with progressive mitochondrial myopathy, congenital cataracts, hearing loss, developmental delay, lactic acidosis and respiratory chain deficiency in 3 siblings born to consanguineous Moroccan parents by homozygosity mapping and candidate gene approach (OMIM#613076). Next generation sequencing recently confirmed this association by the finding of compound heterozygous variants in 19-year-old girl with a strikingly similar phenotype, but this ultra-rare entity remains however unknown from most of the scientific community. Whole exome sequencing was performed as part of a "diagnostic odyssey" for suspected mitochondrial condition in two patients, presenting congenital cataracts, progressive encephalomyopathy and hypotrophy and detected unreported compound heterozygous variants in GFER. Read More

    A case of rapid progression of postoperative hyperthermia: Dantrolene or not dilemma?
    Int J Crit Illn Inj Sci 2016 Oct-Dec;6(4):203-205
    Department of Anesthesiology and Pain Medicine, Seattle Children's Hospital, Seattle, WA 98105, USA.
    Malignant hyperthermia (MH) is an extremely rare and life-threatening differential diagnosis of postoperative fever. We present an 8-month-old child scheduled for elective outpatient procedure who rapidly developed high fever, tachycardia, and respiratory acidosis shortly after transfer to the postanesthesia care unit. MH hotline expert recommended administering dantrolene, but there was no evidence of hypermetabolism or lactic acidosis. Read More

    Bilateral putaminal necrosis in a comatose patient with metabolic acidosis.
    Indian J Crit Care Med 2016 Dec;20(12):745-748
    Department of Neurology, Institute of Neurological Sciences, Apollo Hospitals, Hyderabad, Telangana, India.
    We present a case of acute-onset coma in a young woman, associated with metabolic acidosis, respiratory distress, and hypotension. Magnetic resonance imaging of the brain done on day 2 of admission showed features of bilateral putaminal necrosis. History of methanol ingestion, though not forthcoming at admission, was confirmed later after the patient regained consciousness. Read More

    Acidosis Activates Endoplasmic Reticulum Stress Pathways through GPR4 in Human Vascular Endothelial Cells.
    Int J Mol Sci 2017 Jan 27;18(2). Epub 2017 Jan 27.
    Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA;.
    Acidosis commonly exists in the tissue microenvironment of various pathophysiological conditions such as tumors, inflammation, ischemia, metabolic disease, and respiratory disease. For instance, the tumor microenvironment is characterized by acidosis and hypoxia due to tumor heterogeneity, aerobic glycolysis (the "Warburg effect"), and the defective vasculature that cannot efficiently deliver oxygen and nutrients or remove metabolic acid byproduct. How the acidic microenvironment affects the function of blood vessels, however, is not well defined. Read More

    [Metabolic acidosis].
    G Ital Nefrol 2016 Nov-Dec;33(6)
    Metabolic acidosis is frequently observed in clinical practice, especially among critically ill patients and/or in the course of renal failure. Complex mechanisms are involved, in most cases identifiable by medical history, pathophysiology-based diagnostic reasoning and measure of some key acid-base parameters that are easily available or calculable. On this basis the bedside differential diagnosis of metabolic acidosis should be started from the identification of the two main subtypes of metabolic acidosis: the high anion gap metabolic acidosis and the normal anion gap (or hyperchloremic) metabolic acidosis. Read More

    A definition of gentle ventilation in congenital diaphragmatic hernia: a survey of neonatologists and pediatric surgeons.
    J Perinat Med 2017 Jan 28. Epub 2017 Jan 28.
    Ventilation practices have changed significantly since the initial reports in the mid 1980 of successful use of permissive hypercapnia and spontaneous ventilation [often called gentle ventilation (GV)] in infants with congenital diaphragmatic hernia (CDH). However, there has been little standardization of these practices or of the physiologic limits that define GV. We sought to ascertain among Diaphragmatic Hernia Research and Exploration; Advancing Molecular Science (DHREAMS) centers' GV practices in the neonatal management of CDH. Read More

    MELAS (Mitochondrial Encephalomyopathy, Lactic Acidosis, Stroke) - a Diagnosis Not to be Missed.
    Ir Med J 2016 Sep 9;109(8):455. Epub 2016 Sep 9.
    Departments of Paediatrics, Neurology and Radiology, Childrens University Hospital, Temple St, Dublin 1.
    MELAS is a rare mitochondrial disorder. We report two cases in Irish males where the characteristics were evident, but the diagnosis not made for a considerable period of time. In one of the cases the symptoms were presumed secondary to prematurity. Read More

    Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome.
    Intensive Care Med 2017 Feb 20;43(2):200-208. Epub 2017 Jan 20.
    CIBER Enfermedades Respiratorias, Madrid, Spain.
    Purpose: To analyze the relationship between hypercapnia developing within the first 48 h after the start of mechanical ventilation and outcome in patients with acute respiratory distress syndrome (ARDS).

    Patients And Methods: We performed a secondary analysis of three prospective non-interventional cohort studies focusing on ARDS patients from 927 intensive care units (ICUs) in 40 countries. These patients received mechanical ventilation for more than 12 h during 1-month periods in 1998, 2004, and 2010. Read More

    Preventing Hospitalizations From Acute Exacerbations of Chronic Obstructive Pulmonary Disease.
    Am J Med Sci 2017 Jan 2;353(1):31-40. Epub 2016 Jul 2.
    , Johnson City, Tennessee.
    Chronic obstructive lung disease is among the leading causes of adult hospital admissions and readmissions in the United States. Preventing acute exacerbations is the primary approach in therapy. Combinations of smoking cessation, pulmonary rehabilitation, vaccinations and inhaled and oral medications may all reduce the overall risk of acute exacerbations. Read More

    Strategies to Prevent Cast Formation in Patients with Plastic Bronchitis Undergoing Heart Transplantation.
    Pediatr Cardiol 2017 Jan 19. Epub 2017 Jan 19.
    The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.
    Plastic bronchitis, a rare complication after Fontan palliation, carries a high morbidity and mortality risk. Heart transplantation is an effective treatment option, but casts may occur in the early post-operative period. We present a case series detailing peri-operative management strategies to minimize morbidity and mortality related to plastic bronchitis in patients undergoing heart transplantation. Read More

    Sepsis-related acute respiratory distress syndrome in children with cancer: the respiratory dynamics of a devastating condition.
    Rev Bras Ter Intensiva 2016 Oct-Dec;28(4):436-443
    Departamento de Oncologia Pediátrica, Grupo de Apoio ao Adolescente e à Criança com Câncer, Instituto de Oncologia Pediátrica, Universidade Federal de São Paulo - São Paulo (SP), Brasil.
    Objective:: To evaluate the clinical course and respiratory parameters of mechanically ventilated children with cancer suffering from sepsis-related acute respiratory distress syndrome.

    Methods:: This 2-year prospective, longitudinal, observational cohort study enrolled 29 children and adolescents. Clinical data, measurements of blood gases and ventilation parameters were collected at four different time points. Read More

    Disseminated adenovirus infection causing severe ARDS.
    BMJ Case Rep 2017 Jan 17;2017. Epub 2017 Jan 17.
    Department of Infectious Diseases, Ohio State University College of Medicine, Columbus, Ohio, USA.
    A previously healthy young man with a rare genetic condition presented with severe acute respiratory distress syndrome secondary to pneumonia with septic shock. He did not improve with conventional therapy for his known causal organism thus prompting further workup. He was found to be profoundly immunosuppressed raising our suspicion for atypical organisms. Read More

    Non-invasive respiratory support for infants with bronchiolitis: a national survey of practice.
    BMC Pediatr 2017 Jan 17;17(1):20. Epub 2017 Jan 17.
    Children's Acute Transport Service, Great Ormond Street Hospital NHS Foundation Trust, London, UK.
    Background: Bronchiolitis is a common respiratory illness of early childhood. For most children it is a mild self-limiting disease but a small number of children develop respiratory failure. Nasal continuous positive airway pressure (nCPAP) has traditionally been used to provide non-invasive respiratory support in these children, but there is little clinical trial evidence to support its use. Read More

    Clinical indicators of blood gas disturbances, elevated L-lactate concentration and other abnormal blood parameters in newborn beef calves.
    Vet J 2017 Jan 6;219:49-57. Epub 2016 Dec 6.
    Department of Production Animal Health, University of Calgary Faculty of Veterinary Medicine, 3330 Hospital Dr. NW, Calgary, AB T2N 4N1, Canada. Electronic address:
    Blood gas disturbances, commonly resulting from dystocia, are associated with failed transfer of passive immunity, morbidity and mortality in newborn calves. Modified APGAR scores intended to identify compromised calves are not widely adopted due to lack of practicality and inconsistent associations with blood parameters. The objective of this study was to determine clinical indicators of acidemia in newborn beef calves. Read More

    The midpoint between ventilatory thresholds approaches maximal lactate steady state intensity in amateur cyclists.
    Biol Sport 2016 Dec 10;33(4):373-380. Epub 2016 Oct 10.
    Department of Health and Human Performance, Technical University of Madrid, Madrid, Spain.
    The aim was to determine whether the midpoint between ventilatory thresholds (MPVT) corresponds to maximal lactate steady state (MLSS). Twelve amateur cyclists (21.0 ± 2. Read More

    Assessment of the optimal operating parameters during extracorporeal CO2 removal with the Abylcap® system.
    Int J Artif Organs 2017 Jan 12. Epub 2017 Jan 12.
    Intensive Care, Ghent University Hospital, Ghent - Belgium.
    Purpose: Lung protective ventilation is recommended in patients with acute respiratory distress syndrome (ARDS) needing mechanical ventilation. This can however be associated with hypercapnia and respiratory acidosis, such that extracorporeal CO2 removal (ECCO2R) can be applied. The aim of this study was to derive optimal operating parameters for the ECCO2R Abylcap® system (Bellco, Italy). Read More

    Treatment of Acidified Blood Using Reduced Osmolarity Mixed-Base Solutions.
    Front Physiol 2016 26;7:625. Epub 2016 Dec 26.
    Medical and Research Services, Veterans Health Administration Greater Los Angeles Area Healthcare SystemLos Angeles, CA, USA; Division of Nephrology, Veterans Health Administration Greater Los Angeles Area Healthcare SystemLos Angeles, CA, USA; Membrane Biology Laboratory, David Geffen School of Medicine, University of California, Los AngelesLos Angeles, CA, USA.
    We hypothesize that reduced osmolarity mixed-base (ROMB) solutions can potentially serve as customizable treatments for acidoses, going beyond standard solutions in clinical use, such as 1.0 M sodium bicarbonate. Through in silico quantitative modeling, by treating acidified canine blood using ROMB solutions, and by performing blood-gas and optical microscopy measurements in vitro, we demonstrate that ROMB solutions having a high proportion of a strong base, such as disodium carbonate or sodium hydroxide, can be effective in reducing carbon dioxide pressure PCO2 while raising pH and bicarbonate ion concentration without causing significant osmotic damage to red blood cells, which can occur during rapid administration of hypertonic solutions of weak bases. Read More

    Respiratory gas exchange as a new aid to monitor acidosis in endotoxemic rats: relationship to metabolic fuel substrates and thermometabolic responses.
    Physiol Rep 2017 Jan;5(1)
    Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
    This study introduces the respiratory exchange ratio (RER; the ratio of whole-body CO2 production to O2 consumption) as an aid to monitor metabolic acidosis during the early phase of endotoxic shock in unanesthetized, freely moving rats. Two serotypes of lipopolysaccharide (lipopolysaccharide [LPS] O55:B5 and O127:B8) were tested at shock-inducing doses (0.5-2 mg/kg). Read More

    Activity of Tachykinin1-Expressing Pet1 Raphe Neurons Modulates the Respiratory Chemoreflex.
    J Neurosci 2017 Feb 16;37(7):1807-1819. Epub 2017 Jan 16.
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, and
    Homeostatic control of breathing, heart rate, and body temperature relies on circuits within the brainstem modulated by the neurotransmitter serotonin (5-HT). Mounting evidence points to specialized neuronal subtypes within the serotonergic neuronal system, borne out in functional studies, for the modulation of distinct facets of homeostasis. Such functional differences, read out at the organismal level, are likely subserved by differences among 5-HT neuron subtypes at the cellular and molecular levels, including differences in the capacity to coexpress other neurotransmitters such as glutamate, GABA, thyrotropin releasing hormone, and substance P encoded by the Tachykinin-1 (Tac1) gene. Read More

    Is potassium thiosulfate a poison? Is it safe? A case series.
    J Pak Med Assoc 2017 Jan;67(1):137-139
    Department of Emergency Medicine, Marmara University Pendik Research and Training Hospital, Istanbul, Turkey.
    Potassium Thiosulfate is a liquid substance used for producing fertilizers. In this case series, we present five patients who have been exposed to potassium thiosulfate inhalation. Three of them were intubated in the scene by paramedics because of confusion and respiratory depression. Read More

    3-MeO-PCP intoxication in two young men: First in vivo detection in Italy.
    Forensic Sci Int 2016 Dec 26. Epub 2016 Dec 26.
    Forensic Toxicology Division, Department of Health Science, University of Florence, Italy. Electronic address:
    3-MeO-PCP or 3-methoxyphencyclidine is a derivative of phencyclidine. It acts as a dissociative anesthetic and it has allegedly hallucinogenic and sedative effects. There are almost no documented intoxication cases and references about its pharmacology and toxicity in literature. Read More

    Assessment of resuscitation as measured by markers of metabolic acidosis and features of injury.
    Bone Joint J 2017 Jan;99-B(1):122-127
    MetroHealth Medical Center, Case Western Reserve University, Department of Orthopaedic Surgery, 2500 MetroHealth Drive, Cleveland, Ohio, 44109, USA.
    Aims: The best time for definitive orthopaedic care is often unclear in patients with multiple injuries. The objective of this study was make a prospective assessment of the safety of our early appropriate care (EAC) strategy and to evaluate the potential benefit of additional laboratory data to determine readiness for surgery.

    Patients And Methods: A cohort of 335 patients with fractures of the pelvis, acetabulum, femur, or spine were included. Read More

    Severe Hypoxemia in Muskoxen ( Ovibos moschatus ) Immobilized with Etorphine and Xylazine Corrected with Supplemental Nasal Oxygen.
    J Wildl Dis 2017 Jan 4. Epub 2017 Jan 4.
    3 Department of Forestry and Wildlife Management, Hedmark University of Applied Sciences, Campus Evenstad, NO-2480 Koppang, Norway.
    Twenty-three muskoxen ( Ovibos moschatus ) housed in a captive facility for rewilding in Sweden were chemically immobilized for annual health evaluations and hoof trimming. The muskoxen were darted in May to September (2012-2015) in their holding pen with etorphine (0.015 mg/kg) and xylazine (0. Read More

    The effectiveness of apneic oxygenation during tracheal intubation in various clinical settings: a narrative review.
    Can J Anaesth 2017 Jan 3. Epub 2017 Jan 3.
    Department of Anesthesia, Toronto Western Hospital, University Health Network, University of Toronto, MC2-405, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada.
    Purpose: During the process of tracheal intubation, patients are apneic or hypoventilating and are at risk of becoming hypoxemic. This risk is especially high in patients with acute or chronic respiratory failure and accompanying compromised respiratory reserve. To address this concern, apneic oxygenation can be administered during tracheal intubation to aid in maintaining arterial oxygen saturation. Read More

    The dangers of accepting a single diagnosis: case report of concurrent Plasmodium knowlesi malaria and dengue infection.
    Malar J 2017 Jan 3;16(1). Epub 2017 Jan 3.
    Hospital Raja Perempuan Zainab II, 15000, Kota Bharu, Kelantan, Malaysia.
    Background: Dengue and malaria are two common, mosquito-borne infections, which may lead to mortality if not managed properly. Concurrent infections of dengue and malaria are rare due to the different habitats of its vectors and activities of different carrier mosquitoes. The first case reported was in 2005. Read More

    Mutations in the accessory subunit NDUFB10 result in isolated complex I deficiency and illustrate the critical role of intermembrane space import for complex I holoenzyme assembly.
    Hum Mol Genet 2016 Dec 30. Epub 2016 Dec 30.
    Department of Chemistry, Institute of Biochemistry, University of Cologne, Cologne, Germany
    An infant presented with fatal infantile lactic acidosis and cardiomyopathy, and was found to have profoundly decreased activity of respiratory chain complex I in muscle, heart and liver. Exome sequencing revealed compound heterozygous mutations in NDUFB10, which encodes an accessory subunit located within the PD part of complex I. One mutation resulted in a premature stop codon and absent protein, while the second mutation replaced the highly conserved cysteine 107 with a serine residue. Read More

    Respiratory acidosis in obese gynecological patients undergoing laparoscopic surgery independently of the type of ventilation.
    Acta Anaesthesiol Taiwan 2016 Dec 1;54(4):131-133. Epub 2016 Dec 1.
    Moscow Institute of Physics and Technology (State University), Dolgoprudny, Moscow Region, Russia; The Russian National Research Medical University named after N.I. Pirogov, Moscow, Russia. Electronic address:

    Mitochondrial respiratory chain complex I deficiency causes intractable gastrointestinal symptoms.
    Pediatr Int 2016 Dec 6;58(12):1337-1340. Epub 2016 Nov 6.
    Division of Perinatology and Pediatrics, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan.
    We report the case of a 13-month-old girl with frequent vomiting, intractable diarrhea, hyperlactatemia, and liver dysfunction. Although the symptoms were treatment resistant, enteral nutrition formula containing medium-chain triglycerides reduced the weight loss, vomiting, and diarrhea. Immunostaining of mitochondrial respiratory chain (MRC) complexes of the colonic mucosa confirmed the diagnosis of MRC complex I deficiency. Read More

    Nasal flaring as a clinical sign of respiratory acidosis in patients with dyspnea.
    Am J Emerg Med 2016 Dec 10. Epub 2016 Dec 10.
    Universitat Internacional de Catalunya (UIC), Sant Cugat del Vallès, Barcelona, Spain; Intensive Care Unit, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Barcelona, Spain.
    Objective: To determine whether the presence of nasal flaring is a clinical sign of respiratory acidosis in patients attending emergency departments for acute dyspnea.

    Methods: Single-center, prospective, observational study of patients aged over 15 requiring urgent attention for dyspnea, classified as level II or III according to the Andorran Triage Program and who underwent arterial blood gas test on arrival at the emergency department. The presence of nasal flaring was evaluated by two observers. Read More

    Early severe acute respiratory distress syndrome: What's going on? Part II: controlled vs. spontaneous ventilation?
    Anaesthesiol Intensive Ther 2016 ;48(5):339-351
    Physiology, Claude Bernard University, University of Lyon, Lyon, France.
    The second part of this overview on early severe ARDS delineates the pros and cons of the following: a) controlled mechanical ventilation (CMV: lowered oxygen consumption and perfect patient-to-ventilator synchrony), to be used during acute cardio-ventilatory distress in order to "buy time" and correct circulatory insufficiency and metabolic defects (acidosis, etc.); b) spontaneous ventilation (SV: improved venous return, lowered intrathoracic pressure, absence of muscle atrophy). Given a stabilized early severe ARDS, as soon as the overall clinical situation improves, spontaneous ventilation will be used with the following stringent conditionalities: upfront circulatory optimization, upright positioning, lowered VO2, lowered acidotic and hypercapnic drives, sedation without ventilatory depression and without lowered muscular tone, as well as high PEEP (titrated on transpulmonary pressure, or as a second best: "trial"-PEEP) with spontaneous ventilation + pressure support (or newer modes of ventilation). Read More

    Changes of Respiratory Mechanics in COPD Patients from Stable State to Acute Exacerbations with Respiratory Failure.
    COPD 2016 Dec 20:1-6. Epub 2016 Dec 20.
    c Institute of Respiratory Diseases, Policlinico S. Orsola and Alma Mater University , Bologna , Italy.
    Symptoms, clinical course, functional and biological data during an exacerbation of chronic obstructive pulmonary disease (EXCOPD) have been investigated, but data on physiological changes of respiratory mechanics during a severe exacerbation with respiratory acidosis requiring noninvasive mechanical ventilation (NIMV) are scant. The aim of this study was to evaluate changes of respiratory mechanics in COPD patients comparing data observed during EXCOPD with those observed during stable state in the recovery phase. In 18 COPD patients having severe EXCOPD requiring NIMV for global respiratory failure, we measured respiratory mechanics during both EXCOPD (T0) and once the patients achieved a stable state (T1). Read More

    [Phenotypic and genetic analysis of a family affected with microvillus inclusion disease].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2016 Dec;33(6):792-796
    Center of Clinical Laboratory Medicine, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510630, China. .
    Objective: To explore the clinical features and mutations of MYO5B gene in a family affected with microvillus inclusion disease.

    Methods: Clinical data of an infant affected with microvillus inclusion disease was collected. Genomic DNA was extracted from peripheral blood samples from the patient and her parents. Read More

    Bicarbonate Increases Ischemia-Reperfusion Damage by Inhibiting Mitophagy.
    PLoS One 2016 14;11(12):e0167678. Epub 2016 Dec 14.
    Cedars-Sinai Heart Institute, Los Angeles, California, United States of America.
    During an ischemic event, bicarbonate and CO2 concentration increase as a consequence of O2 consumption and lack of blood flow. This event is important as bicarbonate/CO2 is determinant for several redox and enzymatic reactions, in addition to pH regulation. Until now, most work done on the role of bicarbonate in ischemia-reperfusion injury focused on pH changes; although reperfusion solutions have a fixed pH, cardiac resuscitation protocols commonly employ bicarbonate to correct the profound acidosis associated with respiratory arrest. Read More

    [Lactic acidosis in a 24-year-old woman with status asthmaticus].
    Ugeskr Laeger 2016 Dec;178(50)
    A 24-year-old woman with asthma presented with symptoms of upper airway infection and tachypnoea and wheezes. She had a history of admissions to intensive care units (ICU) due to respiratory insufficiency. The initial lactate concentration was 2. Read More

    Mixed acid-base disorder secondary to topiramate use in traumatic brain injury.
    Indian J Nephrol 2016 Nov-Dec;26(6):452-454
    Department of Neurosurgery, Yashoda Hospitals, Secunderabad, Telangana, India.
    We report a case of a man with traumatic brain injury. He was started on to prophylactic topiramate which led to a mixed acid-base disorder. He had severe metabolic acidosis secondary to renal tubular acidification defect and respiratory alkalosis secondary to hyperventilation. Read More

    A Quick Reference on Respiratory Acidosis.
    Vet Clin North Am Small Anim Pract 2017 Mar 8;47(2):185-189. Epub 2016 Dec 8.
    Department of Surgical Sciences, University of Wisconsin - Madison, 2015 Linden Drive, Madison, WI 53706, USA. Electronic address:
    Respiratory acidosis, or primary hypercapnia, occurs when carbon dioxide production exceeds elimination via the lung and is mainly owing to alveolar hypoventilation. Concurrent increases in Paco2, decreases in pH and compensatory increases in blood HCO3(-) concentration are associated with respiratory acidosis. Respiratory acidosis can be acute or chronic, with initial metabolic compensation to increase HCO3(-) concentrations by intracellular buffering. Read More

    ECMO for intractable status asthmaticus following atracurium.
    J Artif Organs 2016 Dec 8. Epub 2016 Dec 8.
    Dipartimento di Anestesia, Rianimazione ed Emergenza Urgenza, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, MI, Italy.
    Intraoperative allergic reactions are rare but serious events associated with increased morbidity and mortality. We report the salvage of intraoperative anaphylaxis leading to extreme hypercapnic respiratory failure by veno-venous extracorporeal membrane oxygenation (ECMO). A 38-year-old woman undergoing thyroidectomy developed intractable bronchospasm after administration of atracurium, leading to extreme hypercapnic respiratory failure (PaCO2 > 250 mmHg, pH 6. Read More

    Intercalated Cell Depletion and Vacuolar H+-ATPase Mistargeting in an AE1 R607H Knockin Model.
    J Am Soc Nephrol 2016 Dec 8. Epub 2016 Dec 8.
    Institute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Jena, Germany;
    Distal nephron acid secretion is mediated by highly specialized type A intercalated cells (A-ICs), which contain vacuolar H(+)-ATPase (V-type ATPase)-rich vesicles that fuse with the apical plasma membrane on demand. Intracellular bicarbonate generated by luminal H(+) secretion is removed by the basolateral anion-exchanger AE1. Chronically reduced renal acid excretion in distal renal tubular acidosis (dRTA) may lead to nephrocalcinosis and renal failure. Read More

    Membrane Oxygenator Use With Biventricular Assist Device: Facilitation of Support and Lung Recovery.
    World J Pediatr Congenit Heart Surg 2016 Dec 6. Epub 2016 Dec 6.
    Division of Cardiothoracic Surgery, Department of Surgery, the Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    We present the use of a low-resistance membrane oxygenator (Quadrox D, Maquet) in series with a pulsatile right ventricular assist device (Berlin Heart EXCOR, Berlin Heart) in a patient with biventricular support who required high-frequency oscillatory ventilation (HFOV), due to refractory acute respiratory distress syndrome associated with Cytomegalovirus pneumonia. The high mean airway pressure associated with the use of HFOV resulted in a significant negative impact on left ventricular assist device (LVAD) filling that led to a combined respiratory and metabolic acidosis and the need for vasopressor support. Oxygenator placement enabled transition to conventional ventilation and the discontinuation of vasopressor support. Read More

    [Severe hypercapnic respiratory failure in acute exacerbation of COPD: significance of ventilation and extracorporal CO2 removal].
    Dtsch Med Wochenschr 2016 Nov 30;141(24):1758-1762. Epub 2016 Nov 30.
    In acute exacerbations of COPD with acute hypercapnic respiratory failure and a pH 7.25 - 7.35, the initiation of non-invasive ventilation is the gold standard. Read More

    Global cerebral ischemia due to circulatory arrest: insights into cellular pathophysiology and diagnostic modalities.
    Mol Cell Biochem 2017 Feb 28;426(1-2):111-127. Epub 2016 Nov 28.
    Division of Cardiovascular Diseases, Department of Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA.
    Circulatory arrest (CA) remains a major unresolved public health problem in the United States; the annual incidence of which is ~0.50 to 0.55 per 1000 population. Read More

    1 OF 145