J Crit Care 2021 Feb 26;64:10-17. Epub 2021 Feb 26.
Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; Department of Intensive Care, Austin Hospital, Heidelberg, Victoria, Australia; Department of Intensive Care, Royal Melbourne Hospital, Melbourne, Victoria, Australia; Centre for Integrated Critical Care, Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia; Data Analytics Research and evaluation Centre, The University of Melbourne and Austin Hospital, Melbourne, Australia.
Purpose: To study the prevalence, characteristic, outcome, and acid-base biomarker predictors of outcome for different acidemia subtypes.
Methods: We used national intensive care databases from three countries and classified acidemia subtypes as metabolic (standard base excess [SBE] < -2 mEq/L only), respiratory (PaCO > 42 mmHg only), and combined (both SBE < -2 mEq/L and PaCO > 42 mmHg) based on blood gas analysis in the first 24 h after ICU admission. To investigate acid-base predictors for hospital mortality, we applied the area under the receiver operating characteristic curve approach. Read More