Vinculin variant M94I identified in sudden unexplained nocturnal death syndrome decreases cardiac sodium current.
- Jianding Cheng,
- John W Kyle,
- Brandi Wiedmeyer,
- Di Lang,
- Ravi Vaidyanathan,
- Jonathan C Makielski
Sci Rep 2017 Feb 20;7:42953. Epub 2017 Feb 20.
Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison, WI 53792, USA.
Sudden unexplained nocturnal death syndrome (SUNDS) remains an autopsy negative disorder with unclear etiology. Vinculin (VCL) was linked to sudden arrhythmia death in VCL knockout mice prior to the appearance of cardiomyopathy. We hypothesized VCL mutations underlie risk for SUNDS. Read More