J Am Soc Nephrol 2018 Apr 20. Epub 2018 Apr 20.
Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Urine citrate is reabsorbed exclusively along the renal proximal tubule the apical Na-dicarboxylate cotransporter NaDC-1. We previously showed that an acid load and media acidification increase NaDC-1 activity through endothelin-1 (ET-1)/endothelin B (ET) signaling. Here, we further examined the signaling pathway mediating acid-induced NaDC-1 activity. Read More