Search Our Scientific Publications & Authors

J Vet Emerg Crit Care (San Antonio) 2021 Apr 30. Epub 2021 Apr 30.

California Animal Health and Food Safety Lab, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.

Objective: To describe the clinical course and novel biochemical findings in 3 dogs with amitraz toxicosis.

Case Series Summary: Three Labrador Retrievers developed acute onset obtundation to stupor after being in a rice field. On admittance to the hospital, they all displayed bradycardia, hyperglycemia, hyperlactatemia, respiratory acidosis, and metabolic alkalosis. Read More

Clin Nephrol Case Stud 2021 26;9:49-53. Epub 2021 Apr 26.

Department of Medicine, Nephrology Section, University of Miami Miller School of Medicine/Miami VAMC, and.

Introduction: Lactic acidosis (LA) can be categorized as type A, which occurs in the presence of tissue hypoxia, or type B, occurring in the absence of tissue hypoxia. Hematologic malignancies are an uncommon cause of type B LA.

Case Presentation: A 63-year-old man, HIV-negative, with a history of diabetes mellitus, hypothyroidism, and non-alcoholic fatty liver disease (NAFLD), presented to the ED complaining of acute-on-chronic lumbar pain, and was found to have high serum anion gap (AG) LA. Read More

Laryngoscope 2021 Apr 29. Epub 2021 Apr 29.

Department of Otolaryngology - Head & Neck Surgery, Tufts University School of Medicine, Boston, Massachusetts, U.S.A.

Objectives/hypothesis: To describe the use of capillary blood gas (CBG) sampling to detect and quantify hypoventilation in infants with Robin sequence (RS).

Methods: Case series with chart review at two institutions. Infants with RS presenting over a 10-year period were identified using departmental databases. Read More

Sci Rep 2021 04 22;11(1):8731. Epub 2021 Apr 22.

Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Coronavirus disease 2019 (COVID-19) can present with a variety of symptoms. Severity of the disease may be associated with several factors. Here, we review clinical features of COVID-19 inpatients with different severities. Read More

Cureus 2021 Mar 17;13(3):e13958. Epub 2021 Mar 17.

Department of Diabetology and Endocrinology, Mohammed VI University Hospital, Mohamed I University, Oujda, MAR.

During the course of this year, scientific research has revolved around coronavirus disease 2019 (COVID-19), with much uncertainty surrounding its pathogenesis, complications, and mortality as well as limited pediatric evidence. The exact relationship between COVID-19 and new-onset type 1 diabetes, especially in children, remains an unresolved issue. Our case exhibited a unique presentation of diabetic ketoacidosis (DKA) triggering COVID-19 diagnosis at this age. Read More

BMC Emerg Med 2021 Apr 20;21(1):52. Epub 2021 Apr 20.

Emergency Intensive Care Unit, The Second Affiliated Hospital of Nantong University, Nantong First People's Hospital, 6 Haier Xiang North Road, Nantong, 226001, Jiangsu, China.

Background: Endothelial glycocalyx (EG) abnormal degradation were widely found in critical illness. However, data of EG degradation in multiple traumas is limited. We performed a study to assess the EG degradation and the correlation between the degradation and organ functions in polytrauma patients. Read More

BMJ Case Rep 2021 Apr 19;14(4). Epub 2021 Apr 19.

Obstetrics & Gynaecology, Amsterdam UMC Location AMC, Amsterdam, North Holland, The Netherlands.

We present a case of a metabolic acidosis in a term-pregnant woman with SARS-CoV-2 infection.Our patient presented with dyspnoea, tachypnoea, thoracic pain and a 2-day history of vomiting, initially attributed to COVID-19 pneumonia. Differential diagnosis was expanded when arterial blood gas showed a high anion gap metabolic non-lactate acidosis without hypoxaemia. Read More

J Emerg Nurs 2021 Apr 13. Epub 2021 Apr 13.

Kratom ingestion for its psychotropic effect or to self-treat opioid withdrawal symptoms has increased over the last 10 years in the United States. Although mild adverse effects have been observed in users, reports of respiratory failure and shock after kratom consumption remain rare. In this case, a 35-year-old man initially presented to the emergency department with profound circulatory shock, metabolic acidosis, hypoxia, and symptoms of autonomic nervous system dysfunction. Read More

Front Vet Sci 2021 29;8:655345. Epub 2021 Mar 29.

Department of Forestry and Wildlife Management, Inland Norway University of Applied Sciences, Koppang, Norway.

Three medetomidine-based drug protocols were compared by evaluating time courses, reliability and physiological effects in wild boars. A total of 21 cage-trapped wild boars () were immobilized using one of the following drug combinations; MTZ: medetomidine (0.2 mg/kg) + tiletamine-zolazepam (2. Read More

J Med Case Rep 2021 Apr 8;15(1):200. Epub 2021 Apr 8.

Unit of Intensive Care, Department of Emergency, "A. Cardarelli" Hospital, Naples, Italy.

Background: Acute severe asthma is a life-threatening medical emergency. Characteristics of asthma include increased airway resistance and dynamic pulmonary hyperinflation that can manifest in dangerous levels of hypercapnia and acidosis, with significant mortality and morbidity. Severe respiratory distress can lead to endotracheal intubation followed by mechanical ventilation, which can cause increased air trapping with dynamic hyperinflation, predisposing the lungs to barotraumas. Read More

BMC Psychiatry 2021 04 13;21(1):192. Epub 2021 Apr 13.

Westmead Hospital Intensive Care Unit, Sydney, Australia.

Background: Caffeine is a known inhibitor of Clozapine metabolism mediated by inhibition of CYP1A2. Hitherto, the effects of caffeine on Clozapine levels have always been modest, as have the clinical manifestations of toxicity resulting from their interaction. We present a case of severe toxicity associated with the co-consumption of caffeine and Clozapine culminating in life-threatening complications requiring management in Intensive Care. Read More

Diabetologia 2021 Apr 12. Epub 2021 Apr 12.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China.

Aims/hypothesis: The long-term effects of metformin in individuals with type 2 diabetes who are at increased risk of severe respiratory infections are unknown. This study aimed to evaluate the effects of metformin use on the risk of first pneumonia hospitalisation and pneumonia-related death in a cohort of Chinese individuals with type 2 diabetes.

Methods: We performed a retrospective analysis of a consecutive cohort of 22,638 individuals with type 2 diabetes in the Hong Kong Diabetes Register enrolled between 2001 and 2018, with follow-up until 31 December 2019. Read More

BJR Case Rep 2021 Apr 19;7(2):20200088. Epub 2020 Nov 19.

Department of Radiology, SUNY Upstate Medical University Syracuse, New York, NY, USA.

We present a case of 6-year-old female with history of respiratory distress who went into respiratory failure requiring intubation. Patient was subsequently found to be in hypertensive crisis with hyponatremic hypochloremic metabolic acidosis and acute kidney injury. Renal ultrasound was performed to find the cause of hypertension. Read More

Neuromuscul Disord 2021 Feb 21. Epub 2021 Feb 21.

Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.

Reversible infantile respiratory chain deficiency is a severe neonatal mitochondrial myopathy that resolves spontaneously. It is caused by the homoplasmic m.14674T>C mtDNA mutation and additional nuclear variants in genes interacting with mt-tRNAGlu have been detected in some patients. Read More

Am J Respir Crit Care Med 2021 Apr 6. Epub 2021 Apr 6.

Hospital Clínico Universidad de Chile, Departamento de Medicina, Unidad de Pacientes Críticos, Santiago, Chile.

Rationale: The role and needs of extracorporeal membrane oxygenation (ECMO) at a population-level during the COVID-19 pandemic have not been completely established.

Objectives: To identify the cumulative incidence for ECMO use in the first pandemic wave and to describe the Nationwide Chilean cohort of ECMO-supported COVID-19 patients.

Methods: We conducted a population-based study from March 3 to August 31, 2020, using linked data from National agencies. Read More

BMC Neurol 2021 Apr 5;21(1):147. Epub 2021 Apr 5.

Department of Neurology, Uijeongbu Eulji Medical Center, 712, Dongil-ro, Uijeongbu, 11759, Republic of Korea.

Background: Until recently, it is generally considered safe to perform magnetic resonance imaging (MRI) in patients with an intrathecal drug administration system (ITDAS) device. In this study, we presented a case of morphine overdose due to ITDAS malfunction during MRI evaluation for the diagnosis of stroke.

Case Presentation: A 58-year-old woman was referred to the emergency department for left-sided hemiparesis and dysarthria. Read More

FASEB J 2021 May;35(5):e21532

Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.

TWIK-related acid-sensitive potassium channels (TASKs)-like current was recorded in orexin neurons in the lateral hypothalamus (LH), which are essential in respiratory chemoreflex. However, the specific mechanism responsible for the pH-sensitivity remains elusive. Thus, we hypothesized that TASKs contribute to respiratory chemoreflex. Read More

Wiad Lek 2021 ;74(2):288-290

KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.

Objective: The aim: To study the regulation of acid-base balance and blood acid - renal excretory function in patients with COPD.

Patients And Methods: Materials and methods: We examined 82 people, suggests that even during the most severe stages of COPD. Group 1 included 56 patients with COPD, group C. Read More

J Clin Med 2021 Mar 23;10(6). Epub 2021 Mar 23.

Mater Research Institute, University of Queensland, Level 3 Aubigny Place, Raymond Terrace, South Brisbane, QLD 4101, Australia.

Although the risk of neonatal mortality is generally low for late preterm and early term infants, they are still significantly predisposed to severe neonatal morbidity (SNM) despite being born at relatively advanced gestations. In this study, we investigated maternal and intrapartum risk factors for early SNM in late preterm and early term infants. This was a retrospective cohort study of non-anomalous, singleton infants (34-38 gestational weeks) born at the Mater Mother's Hospital in Brisbane, Australia from January 2015 to May 2020. Read More

Crit Care Explor 2021 Mar 9;3(3):e0372. Epub 2021 Mar 9.

Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA.

Objectives: About 15% of hospitalized coronavirus disease 2019 patients require ICU admission, and most (80%) of these require invasive mechanical ventilation. Lung-protective ventilation in coronavirus disease 2019 acute respiratory failure may result in severe respiratory acidosis without significant hypoxemia. Low-flow extracorporeal Co removal can facilitate lung-protective ventilation and avoid the adverse effects of severe respiratory acidosis. Read More

Cureus 2021 Feb 24;13(2):e13531. Epub 2021 Feb 24.

Pulmonary Critical Care, McLaren Flint Hospital/Michigan State University (MSU), Flint, USA.

E-cigarette-associated lung injury (EVALI) is related to the usage of e-cigarettes or a related product (e.g., "vaping" or "dabbing"). Read More

Neurol Sci 2021 Mar 29. Epub 2021 Mar 29.

Research Institute of Neuromuscular and Neurodegenerative Diseases and Department of Neurology, Qilu Hospital, Shandong University, Jinan, Shandong, China.

Objective: To report a Chinese family with combined m.14459G>A mutation and m.6064A>T mutation of which the female proband presenting unique Leber hereditary optic neuropathy and dystonia (LDYT) overlapping mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) phenotype. Read More

Medicine (Baltimore) 2021 Mar;100(12):e24084

Intensive Care Unit, Wuchang Hospital of Wuhan.

Background: For patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated by respiratory acidosis, noninvasive ventilation therapy is thought to be the first-line treatment. In patients with AECOPD, the effect of high-flow nasal oxygen therapy is not well studied. In this study, the existing data will be synthesized to obtain an effective rate of movement of nasal oxygen therapy in patients with AECOPD. Read More

BMJ Case Rep 2021 Mar 19;14(3). Epub 2021 Mar 19.

Pediatric Pulmonology and Sleep Medicine, Emory University School of Medicine, Atlanta, Georgia, USA

A 20-day-old term infant presented with recurrent apnoea, lethargy and respiratory failure. Examination revealed episodes of apnoea and desaturation to 85% without any signs of respiratory distress requiring initiation of non-invasive positive pressure ventilation (NPPV). Capillary blood gas was indicative of respiratory acidosis and serum bicarbonate was elevated at 35 mmol/L. Read More

JFMS Open Rep 2021 Jan-Jun;7(1):2055116920984748. Epub 2021 Feb 27.

Intensive Care Unit UCICOOP, CABA, Buenos Aires, Argentina.

Case Summary: A 9-year-old neutered male domestic shorthair cat was presented for evaluation of severe hemodynamic collapse and suspected lower urinary tract disease. On admission, severe metabolic acidosis, hyperkalemia and azotemia, and electrocardiographic findings consistent with cardiotoxicity were identified. The diagnosis of uroabdomen was made based on abdominal fluid to plasma concentration ratios of creatinine and potassium. Read More

J Crit Care 2021 Feb 26;64:10-17. Epub 2021 Feb 26.

Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; Department of Intensive Care, Austin Hospital, Heidelberg, Victoria, Australia; Department of Intensive Care, Royal Melbourne Hospital, Melbourne, Victoria, Australia; Centre for Integrated Critical Care, Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia; Data Analytics Research and evaluation Centre, The University of Melbourne and Austin Hospital, Melbourne, Australia.

Purpose: To study the prevalence, characteristic, outcome, and acid-base biomarker predictors of outcome for different acidemia subtypes.

Methods: We used national intensive care databases from three countries and classified acidemia subtypes as metabolic (standard base excess [SBE] < -2 mEq/L only), respiratory (PaCO > 42 mmHg only), and combined (both SBE < -2 mEq/L and PaCO > 42 mmHg) based on blood gas analysis in the first 24 h after ICU admission. To investigate acid-base predictors for hospital mortality, we applied the area under the receiver operating characteristic curve approach. Read More

Front Cell Infect Microbiol 2021 26;11:632965. Epub 2021 Feb 26.

Department of Medicine, Oman Medical Specialty Board, The Royal Hospital, Muscat, Oman.

Introduction: COVID-19 is raising with a second wave threatening many countries. Therefore, it is important to understand COVID-19 characteristics across different countries.

Methods: This is a cross-sectional descriptive study of 525 hospitalized symptomatic COVID-19 patients, from the central federal hospital in Dubai-UAE during period of March to August 2020. Read More

Am J Emerg Med 2021 Mar 2. Epub 2021 Mar 2.

Lehigh Valley Health Network, Department of Emergency, Hospital Medicine/USF Morsani College of Medicine, Cedar Crest Boulevard & I-78, Allentown, PA 18103, USA.

Central neurogenic hyperventilation (CNH) is a neurogenic disorder rarely described within Emergency Medicine literature. CNH is a primary cause of hyperventilation, most commonly due to primary central nervous system neoplasms. Patient presentation varies based on the underlying cause, and may present with a sole chief complaint of dyspnea. Read More

Ann Intensive Care 2021 Mar 11;11(1):43. Epub 2021 Mar 11.

Intensive Care Unit, Geneva University Hospitals, 4, Rue Gabrielle Perret-Gentil, 1205, Geneva, Switzerland.

Background: Chronic obstructive pulmonary disease (COPD) exacerbation and protective mechanical ventilation of acute respiratory distress syndrome (ARDS) patients induce hypercapnic respiratory acidosis.

Main Text: Extracorporeal carbon dioxide removal (ECCOR) aims to eliminate blood CO to fight against the adverse effects of hypercapnia and related acidosis. Hypercapnia has deleterious extrapulmonary consequences, particularly for the brain. Read More

J Appl Physiol (1985) 2021 Mar 11. Epub 2021 Mar 11.

Department of Biology, Faculty of Science and Technology, Mount Royal University, Canada.

Rapid ascent to high altitude imposes an acute hypoxic and acid-base challenge, with ventilatory and renal acclimatization countering these perturbations. Specifically, ventilatory acclimatization improves oxygenation, but with concomitant hypocapnia and respiratory alkalosis. A compensatory, renally-mediated relative metabolic acidosis follows via bicarbonate elimination, normalizing arterial pH(a). Read More