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Front Pediatr 2022 3;10:885633. Epub 2022 May 3.

Pediatric Critical Care Division, Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, TX, United States.

Background: Children with cancer are at risk of critical disease and mortality from COVID-19 infection. In this study, we describe the clinical characteristics of pediatric patients with cancer and COVID-19 from multiple Latin American centers and risk factors associated with mortality in this population.

Methods: This study is a multicenter, prospective cohort study conducted at 12 hospitals from 6 Latin American countries (Argentina, Bolivia, Colombia, Ecuador, Honduras and Peru) from April to November 2021. Read More

J Med Case Rep 2022 May 17;16(1):192. Epub 2022 May 17.

Department of Internal Medicine, Emam Sajad Hospital, Yasuj University of Medical Sciences, Yasuj, Iran.

Background: Aluminum phosphide (rice tablet) is a highly efficient agent for preserving grains against rodents and insects. It accounts for a large number of poisoning cases. Aluminum phosphide poisoning has a high mortality rate of about 90%, and to date, no antidote is available. Read More

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2022 Mar;34(3):260-264

Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. Corresponding author: Wang Daoxin, Email:

Objective: To investigate the value of machine learning methods for predicting in-hospital mortality in trauma patients with acute respiratory distress syndrome (ARDS).

Methods: A retrospective non-intervention case-control study was performed. Trauma patients with ARDS met the Berlin definition were extracted from the the Medical Information Mart for Intensive Care III (MIMIC III) database. Read More

Anaesth Rep 2022 Jan-Jun;10(1):e12164. Epub 2022 May 5.

Department of Anaesthesiology and Intensive Care Saint-Petersburg State University Hospital St. Petersburg Russian Federation.

We report a case of massive carbon dioxide embolism associated with injury to the inferior vena cava, during posterior retroperitoneoscopic adrenalectomy. The presenting clinical features were tachycardia, rapid oxygen desaturation and severe respiratory acidosis, without evidence of bleeding. The patient was resuscitated by increasing the fraction of inspired oxygen, administering intravenous fluid and converting to an open procedure to suture the vein. Read More

Pediatr Transplant 2022 May 14:e14305. Epub 2022 May 14.

Organ Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.

Background: Twenty percent of pediatric patients with BA develop ACLF with increased mortality while awaiting LT. Respiratory complications are common in pediatric ACLF and are associated with increased morbidity and mortality. ARDS is the most severe manifestation of acute respiratory failure with considerable risk of mortality. Read More

Theranostics 2022 4;12(7):3237-3250. Epub 2022 Apr 4.

Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Impaired mitochondrial function contributes to non-alcoholic steatohepatitis (NASH). Acylglycerol kinase (AGK) is a subunit of the translocase of the mitochondrial inner membrane 22 (TIM22) protein import complex. AGK mutation is the leading cause of Sengers syndrome, characterized by congenital cataracts, hypertrophic cardiomyopathy, skeletal myopathy, lactic acidosis, and liver dysfunction. Read More

Clin Med Insights Case Rep 2022 30;15:11795476221093287. Epub 2022 Apr 30.

Child Metabolism Division, Ondokuz Mayıs University, Atakum Samsun, Turkey.

Kwashiorkor is a serious nutritional disease. The 7-month-old male patient presented with severe metabolic acidosis and elevated liver enzymes. His condition was similar to fatty acid oxidation defect. Read More

J Ultrasound 2022 May 5. Epub 2022 May 5.

Department of Emergency Medicine, Emergency Medicine Specialist, Prof. Dr. Cemil Taşçıoğlu City Hospital, Istanbul, Turkey.

Objective: This study aims to determine if there is a correlation between differences in optic nerve sheath diameter (ONSD) and changes in PaCO and pH values that were measured in the arterial blood gas (ABG) before and after treatment in COPD patients with acute hypercarbic respiratory failure (AHRF).

Materials And Methods: This study serves as a prospective self-controlled non-randomized trial study conducted in the emergency clinic of a tertiary hospital. Forty-four patients with COPD, who were found to have acidosis and hypercarbia in ABG and had an indication for non-invasive mechanic ventilation (NIMV), were analyzed prospectively. Read More

Intensive Care Med 2022 May 5. Epub 2022 May 5.

AP-HP, Hôpital Universitaire Ambroise-Paré, Service de Médecine Intensive Réanimation, 92100, Boulogne-Billancourt, France.

Pulm Circ 2022 Jan 23;12(1):e12060. Epub 2022 Mar 23.

Department of Intensive Care Medicine, University Hospital of Heraklion, Medical School University of Crete Heraklion Crete Greece.

Dyspnea on exertion is a devastating symptom, commonly observed in patients with pulmonary hypertension (PH). The pathophysiology of dyspnea in these patients has been mainly attributed to cardiovascular determinants and isolated abnormalities of the respiratory system during exercise, neglecting the contribution of the control of the breathing system. The aim of this review is to provide a novel approach to the interpretation of dyspnea in patients with PH, focused on the impact of the control of the breathing system during exercise. Read More

Cureus 2022 Mar 28;14(3):e23570. Epub 2022 Mar 28.

Department of Medicine, Roger Williams Medical Center, Providence, USA.

Long-term alcohol abuse can cause alcohol-related liver injury (acute alcoholic hepatitis, acute liver failure, hepatic steatosis, fibrosis, or cirrhosis), as well as cardiac injury. Alcoholic cardiomyopathy is a severe consequence of chronic alcohol abuse. Incidence of alcoholic cardiomyopathy ranges from 1-2% of all heavy alcohol users. Read More

Ann Clin Transl Neurol 2022 Apr 28. Epub 2022 Apr 28.

Department of Neurology, Lausanne University Hospital CHUV, Lausanne, Switzerland.

We present a patient who developed, after an early-onset, a stable course of spastic paraplegia and ataxia for 4 decades and eventually succumbed to two episodes of postinfectious lactic acidosis. Diagnostic workup including muscle biopsy and postmortem analysis, oxymetric analysis, spectrophotometric enzyme analysis, and MitoExome sequencing revealed a necrotizing leukoencephalomyelopathy due to the so far unreported biallelic variant of the NDUFV1 gene (p.(Pro122Leu)). Read More

Ann Intensive Care 2022 Apr 21;12(1):36. Epub 2022 Apr 21.

Department of Critical Care, NHS Foundation Trust, Guy's and St ThomasWestminster Bridge Rd, London, SE1 7EH, UK.

Background: Patients presenting with acute hypercapnic respiratory failure due to exacerbations of chronic obstructive pulmonary disease (AECOPD) are typically managed with non-invasive ventilation (NIV). The impact of low-flow extracorporeal carbon dioxide removal (ECCOR) on outcome in these patients has not been explored in randomised trials.

Methods: Open-label randomised trial comparing NIV (NIV arm) with ECCOR (ECCOR arm) in patients with AECOPD at high risk of NIV failure (pH < 7. Read More

J Assoc Physicians India 2022 Apr;70(4):11-12

Sawai Man Singh Medical College and Hospital, Jaipur, Rajasthan.

Sjogren syndrome is an autoimmune disease characterised by lymphocytic infiltration and inflammation of the exocrine glands resulting in decreased secretion of involved glands which manifests mostly as dry eye and dry mouth. The prevalence of the disease is reported to be about 10.3 per 10,000 population. Read More

Front Vet Sci 2022 1;9:842528. Epub 2022 Apr 1.

Discipline of Anesthesiology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Objective: This study aimed to evaluate lung overinflation at different airway inspiratory pressure levels using computed tomography in cats undergoing general anesthesia.

Study Design: Prospective laboratory study.

Animals: A group of 17 healthy male cats, aged 1. Read More

Am J Case Rep 2022 Apr 18;23:e935730. Epub 2022 Apr 18.

College of Medicine and Science, Mayo Clinic, Rochester, MN, USA.

BACKGROUND Metformin-associated lactic acidosis (MALA) is a relatively rare adverse effect of metformin therapy. It usually occurs in patients with metformin overdose or in those with underlying acute and/or chronic conditions resulting in impaired lactate metabolism. Among these, patients with acute kidney injury, heart failure, sepsis, and cirrhosis are the most vulnerable to MALA, even in the setting of appropriate therapy. Read More

Crit Care 2022 04 15;26(1):109. Epub 2022 Apr 15.

Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, No. 2 East Yinghua Road, Chaoyang District, Beijing, 100029, China.

Background: High-flow nasal cannula (HFNC) can improve ventilatory function in patients with acute COPD exacerbation. However, its effect on clinical outcomes remains uncertain.

Methods: This randomized controlled trial was conducted from July 2017 to December 2020 in 16 tertiary hospitals in China. Read More

Am J Emerg Med 2022 Mar 31. Epub 2022 Mar 31.

Department of Critical Care Medicine, Taipei Medical University Hospital, Taipei City, Taiwan; Department of Emergency Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan; Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei City, Taiwan. Electronic address:

We report a case of a young male with amphetamine toxicity initially obscured by concomitant use of gamma-hydroxybutyrate (GHB), and the sympathomimetic symptoms emerged after GHB's effects receded. A 24-year-old unconscious man presented to emergency department showed the following vital signs upon admission: blood pressure 136/58 mmHg; heart rate 79 bpm; SpO2 87% under ambient air; body temperature 36.1 °C; Glasgow Coma Scale score 3. Read More

Ann Med Surg (Lond) 2022 May 8;77:103550. Epub 2022 Apr 8.

Neurology & Neurophysiology Center, Vienna, Austria.

Int J Gen Med 2022 7;15:3121-3132. Epub 2022 Apr 7.

Centre Hospitalier Universitaire de Poitiers, Médecine Intensive Réanimation, Poitiers, France.

Purpose Of Review: High-flow nasal oxygen and noninvasive ventilation are two alternative strategies to standard oxygen in the management of acute respiratory failure.

Discussion: Although high-flow nasal oxygen has gained major popularity in ICUs due to its simplicity of application, good comfort for patients, efficiency in improving oxygenation and promising results in patients with acute hypoxemic respiratory failure, further large clinical trials are needed to confirm its superiority over standard oxygen. Non-invasive ventilation may have deleterious effects, especially in patients exerting strong inspiratory efforts, and no current recommendations support its use in this setting. Read More

Georgian Med News 2022 Mar(324):151-157

2Institute of Toxicology, Federal Biomedical Agency, St. Petersburg, Russia.

A case of acute severe concomitant poisoning with narcotic substances of depreciating and psychostimulating action (1,4 - butanediol, 1-phenyl-2- (1-pyrrolidinyl) -1-pentanone, methadone) complicated by the development of severe hypoxic-ischemic changes in the supratentorial white matter of the large brain is presented. edema and swelling of the brain, nosocomial focal left-sided lower lobe pneumonia in a 25-year-old patient. Psychoactive substances were used for hedonic purposes. Read More

J Card Surg 2022 Apr 11. Epub 2022 Apr 11.

Division of Cardiology, University of Florida College of Medicine, Jacksonville, USA.

Background: The coronavirus disease 2019 (COVID-19) pandemic has significantly burdened the global healthcare system since December 2019. Minority populations are found to have a higher incidence of hospitalization and higher mortality when compared to Caucasians. Extracorporeal membrane oxygenation (ECMO) is reserved for COVID-19 patients who develop respiratory failure refractory to conventional management. Read More

Am J Med Genet A 2022 Apr 8. Epub 2022 Apr 8.

Department of Neurology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.

Myopathy, lactic acidosis, and sideroblastic anemia 2 (MLASA2) is an autosomal recessive mitochondrial disorder caused by pathogenic variants in YARS2. YARS2 variants confer heterogeneous phenotypes ranging from the full MLASA syndrome to a clinically unaffected state. Symptom onset is most common in the first decade of life but can occur in adulthood and has been reported following intercurrent illness. Read More

Intensive Care Med Exp 2022 Apr 4;10(1):11. Epub 2022 Apr 4.

Skåne University Hospital Perioperative and Intensive Care, Entregatan 7, 22242, Lund, Sweden.

Background/aims: Acid-base status is important for understanding pathophysiology, making a diagnosis, planning effective treatment and monitoring progress of critically ill patients. Manual calculations are cumbersome, easily result in wrong conclusions. We wanted to develop an automated assessment of acid-base status. Read More

Am J Emerg Med 2022 Jun 27;56:71-76. Epub 2022 Mar 27.

Department of Emergency Medicine, Faculty of Medicine Ataturk University, Istanbul, Turkey.

Backgrounds: Acute cardiogenic pulmonary edema (ACPE), one of the outcomes of acute heart failure (AHF), is a common reason in a critical condition with respiratory distress. Non-invasive synchronized intermittent mandatory ventilation(nSIMV) mode, which includes inspiratory pressure in addition to positive end expiratory pressure with/without pressure support provided in the non-invasive continuous positive airway pressure plus/pressure support(nCPAP/PS) mode can be effective in hypercarbia and the associated changes in consciousness. This study aimed to demonstrate the efficacy of nSIMV in ACPE. Read More

BMC Pulm Med 2022 Mar 31;22(1):118. Epub 2022 Mar 31.

Department of Radiology, Daping Hospital, Army Medical University, Chongqing, 400042, China.

Background: Noncardiogenic pulmonary edema (NCPE) is a rare and life-threatening allergy-like reaction to the intravascular injection of a nonionic radiographic agent. We first describe a very rare case of fatal NCPE after the intravenous injection of nonionic, iso-osmolar iodine contrast media. Case presentation A 55-year-old male patient was admitted to the hospital with esophageal cancer. Read More

JGH Open 2022 Mar 10;6(3):205-212. Epub 2022 Mar 10.

Department of Medicine, Division of Gastroenterology, Faculty of Medicine Chulalongkorn University and Thai Red Cross Bangkok Thailand.

Background And Aim: Acute-on-chronic liver failure (ACLF) leads to multi-organ failure related to high mortality rates. This study aimed to gather epidemiological data and validate a scoring system to predict mortality in ACLF.

Methods: This retrospective cohort study collected data from multicenter tertiary care hospitals in Thailand. Read More

Perm J 2021 Nov 12;25. Epub 2021 Nov 12.

Department of Cardiology, Thoracic and Cardiovascular Institute, Sparrow Hospital, Lansing, MI.

Introduction: Primary cardiac tumors are rarely seen in the general population and only a subset are classified as cardiac papillary fibroelastoma.

Case Presentation: A 59-year-old female that presented for unresponsiveness and cardiac arrest required 4 rounds of cardiopulmonary resuscitation and intubation. Laboratory investigations showed uncompensated respiratory acidosis, hyperkalemia, and elevated troponins. Read More

Respirol Case Rep 2022 Apr 16;10(4):e0934. Epub 2022 Mar 16.

Department of Pulmonary Medicine St. Luke's International Hospital Tokyo Japan.

We encountered a patient with severe coronavirus disease 2019 (COVID-19)-related pneumonia, who died of progressive respiratory acidosis after 2 months of treatment with mechanical ventilation. The autopsy revealed diffuse alveolar damage (DAD) without any active signs of fungal or bacterial infections, suggesting prolonged and over-activated immune responses against COVID-19 infection. When COVID-19 patients develop acute respiratory distress syndrome, it is essential to remember that the infection can progress to DAD a few months after the disease onset. Read More

Asian J Psychiatr 2022 Jun 21;72:103070. Epub 2022 Mar 21.

Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Jodhpur, Rajasthan 342005, India. Electronic address:

Background: Delirium is a common occurrence in medically compromised adults, but, research is limited in the pediatric population especially from low- and middle-income countries such as India.

Aims: This study aimed to evaluate the emergence of delirium in children aged 5-18 years admitted to a pediatric intensive care unit (PICU) of a tertiary care hospital in North India. Other objectives included delineating the clinical characteristics of delirium and its clinical correlates. Read More