5,592 results match your criteria Respiration[Journal]


Diff-Quik Cytology Smears from Endobronchial Ultrasound Transbronchial Needle Aspiration Lymph Node Specimens as a Source of DNA for Next-Generation Sequencing Instead of Cell Blocks.

Respiration 2019 Feb 7:1-14. Epub 2019 Feb 7.

Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

Background: Next-generation sequencing (NGS) in lung cancer specimens from endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) is usually performed on formalin-fixed paraffin-embedded cell block material.

Objectives: Since DNA can be damaged by this process, we investigated the potential of using DNA extracted from Diff-Quik cytology smears made for rapid on-site evaluation during EBUS-TBNA.

Methods: In a prospective study, 67 patients undergoing diagnostic EBUS-TBNA were ana-lysed. Read More

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http://dx.doi.org/10.1159/000495661DOI Listing
February 2019

Long-Term Ventilation in Neuromuscular Patients: Review of Concerns, Beliefs, and Ethical Dilemmas.

Respiration 2019 Jan 24:1-12. Epub 2019 Jan 24.

Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Palermo, Italy.

Background: Noninvasive mechanical ventilation (NIV) is an effective treatment in patients with neuromuscular diseases (NMD) to improve symptoms, quality of life, and survival.

Summary: NIV should be used early in the course of respiratory muscle involvement in NMD patients and its requirements may increase over time. Therefore, training on technical equipment at home and advice on problem solving are warranted. Read More

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http://dx.doi.org/10.1159/000495941DOI Listing
January 2019
4 Reads

Prevalence and Factors Contributing to Daytime and Nocturnal Hypoxemia in Chronic Heart Failure Patients.

Respiration 2019 Jan 17:1-10. Epub 2019 Jan 17.

Laboratoire HP2, INSERM U 1042, Grenoble Alpes University, Grenoble, France.

Background: Despite clinical optimization, many chronic heart failure (CHF) patients remain symptomatic with dyspnea and poor quality of life.

Study Objective: While oxygen therapy is prescribed in severe cases, the actual prevalence of different patterns of hypoxemia is unknown.

Methods: We analyzed 183 stable CHF patients with optimized medical treatment in the "MARS" database. Read More

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http://dx.doi.org/10.1159/000490734DOI Listing
January 2019
2 Reads

Can Early Introduction of Palliative Care Limit Intensive Care, Emergency and Hospital Admissions in Patients with Severe Chronic Obstructive Pulmonary Disease? A Pilot Randomized Study.

Respiration 2019 Jan 16:1-10. Epub 2019 Jan 16.

Department of Community Medicine, Primary Care, and Emergency, Geneva University Hospitals, Geneva, Switzerland.

Background: Despite their poor prognosis, patients with severe chronic obstructive pulmonary disease (COPD) have little access to palliative care and tend to have a high rate of hospital and intensive care unit (ICU) admissions during their last year of life.

Objectives: To determine the feasibility of a home palliative care intervention during 1 year versus usual care, and the possible impact of this intervention on emergency, hospital and ICU admissions, survival, mood, and health-related quality of life (HRQL).

Methods: Prospective controlled study of patients with severe COPD (GOLD stage III or IV) and long-term oxygen therapy and/or home noninvasive ventilation and/or one or more hospital admissions in the previous year for acute exacerbation, randomized to usual care versus usual care with add-on monthly intervention by palliative care specialists at home for 12 months. Read More

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http://dx.doi.org/10.1159/000495312DOI Listing
January 2019
3 Reads

Acute Respiratory Distress Syndrome following Cardiac Surgery: Comparison of the American-European Consensus Conference Definition versus the Berlin Definition.

Respiration 2019 Jan 16:1-7. Epub 2019 Jan 16.

Department of Cardiac Surgery, Sheba Medical Center (affiliated to the Sackler School of Medicine, Tel Aviv University), Tel Hashomer, Israel.

Background: Lung injury with development of the acute respiratory distress syndrome (ARDS) is a serious complication which can occur after major surgery, including cardiac surgery.

Objective: The aim of our study was to compare the prevalence, risk factors, and mortality of ARDS following cardiac surgery according to the American-European Consensus Conference (AECC) definition and the new Berlin definition of ARDS.

Methods: We performed a retrospective, observational study that included prospectively collected data from consecutive adult patients, aged from 18 to 92 years, who had undergone cardiac surgery (both on and off pump) at a large tertiary university hospital over 5 years (from September 2012 to September 2017). Read More

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https://www.karger.com/Article/FullText/495511
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http://dx.doi.org/10.1159/000495511DOI Listing
January 2019
7 Reads

Chronic Eosinophilic Pneumonia with Cardiac Involvement.

Tanaffos 2018 Feb;17(2):142-145

Department of Cardiology, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Chronic Eosinophilic Pneumonia (CEP) is an idiopathic disorder characterized by an abnormal marked accumulation of eosinophils in the interstitial and alveolar spaces of the lung. CEP is typically suspected in a patient with progressive dyspnoea over one to four months and a chest radiograph showing bilateral peripheral or pleural-based opacities. Dominant extrapulmonary manifestations in CEP are rare. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320557PMC
February 2018
1 Read

Fatal Outcome of Ruptured Pulmonary Hydatid Cyst.

Tanaffos 2018 Feb;17(2):138-141

Tracheal Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences. Tehran, Iran.

Most authors believe that the optimal treatment for pulmonary hydatid cyst is surgery. Albendazole has been used as a prophylactic measure for reducing recurrence rate but there are some controversies about this strategy. Some researchers have described the increased risk of spontaneous rupture of cysts following albendazole treatment. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320564PMC
February 2018
2 Reads

Elastic Band Exercises for Patients with Intensive Care Unit-Acquired Weakness: A Case Report.

Tanaffos 2018 Feb;17(2):132-137

Department of Clinical, Integrated and Experimental Medicine (DIMES), Respiratory and Critical Care Unit, University Hospital St. Orsola-Malpighi, Bologna, Italy.

Intensive care unit-acquired weakness is characterised by severe impairment of muscle function that often arises after prolonged mechanical ventilation, difficult weaning, and severe sepsis. Elastic band exercises constitute an inexpensive and simple technique that is quite appealing for implementation in a "protected environment" such as the intensive care unit; however, elastic band application in the intensive care unit and in critical patients has not yet been described. A 72-year-old male was referred to the respiratory intensive care unit for hypoxemic respiratory failure due to acute respiratory distress syndrome. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320560PMC
February 2018
9 Reads

Successful Treatment of Refractory Massive Pulmonary Embolism with Repeated Administration of Systemic Thrombolysis.

Tanaffos 2018 Feb;17(2):127-131

Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.

Background: We report a case series of two patients in the intensive care unit with massive pulmonary embolism and obstructive shock who had resolution of shock after repeated administration of alteplase.

Case Summaries: Both patients were initially dosed 10 mg of alteplase followed by infusion of 90 mg over 2 hours, but remained in obstructive shock requiring significant inotropic and vasopressor support. Both patients were deemed poor candidates for embolectomy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320563PMC
February 2018
4 Reads

Drug Induced Sleep Endoscopy in Obstructive Sleep Apnea.

Tanaffos 2018 Feb;17(2):122-126

Department of Pulmonary and Critical Care Medicine, Lung Diseases Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.

Background: One of the main challenges of surgical treatment in Obstructive Sleep Apnea (OSA) is identifying the correct site of upper airway obstruction in an individual patient. Drug-Induced Sleep Endoscopy (DISE) in sedated patients with obstructive sleep apnea is the technique of choice for revealing anatomic and dynamic collapsible areas.

Materials And Methods: In a prospective cross-sectional study adult patients with OSA documented by polysomnography were evaluated by sleep endoscopy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320559PMC
February 2018
6 Reads

Role of Telemedicine in Pace of Consultation and Physicians' Satisfaction in Thoracic Surgery ICU.

Tanaffos 2018 Feb;17(2):117-121

Telemedicine Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Science, Tehran, Iran.

Background: Despite various applications of tele-ICU, there are still many questions about its costs and advantages in ICU. Some of its advantages are accelerating consultations and bringing physicians' satisfaction from tele-consultation outcomes. The aim of this study is to discuss these advantages. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320565PMC
February 2018
4 Reads

Is a Low Incidence Rate of Ventilation Associated Pneumonia Associated with Lower Mortality? a Descriptive Longitudinal Study in Iran.

Tanaffos 2018 Feb;17(2):110-116

Department of Anesthesiology and Critical Care, Anesthesiology Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Ventilator-Associated Pneumonia (VAP) is an important cause of morbidity and mortality in patients admitted to Intensive Care Unit (ICU). The current study conducted to estimate VAP incidence, attributable mortality and case fatality rate, cost, so related factors can affect the outcome in patients.

Materials And Methods: In this descriptive longitudinal study, demographic, clinical and para-clinical data were collected and attributable mortality and case fatality rate was estimated. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320555PMC
February 2018
2 Reads

The Effect of Adaptation Training on Controlling Maladaptation Behaviors in Adolescents with Asthma Based on Roy Adaptation Model.

Tanaffos 2018 Feb;17(2):103-109

Nursing and Midwifery Care Research Center, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Asthma is a common long term inflammatory disease during adolescent. Absence of school education and reduction of mental and social mindedness are among the most common problems found in adolescents with asthma. Therefore, the present study was aimed to examine the effect of Roy adaptation model on controlling maladaptation behaviors in adolescents with asthma. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320562PMC
February 2018
13 Reads

Comparison of the Efficacy of Budesonide Nebulizer Suspension and Budesonide Inhalation Suspension in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Tanaffos 2018 Feb;17(2):96-102

Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Inhaled corticosteroids have been successfully used to improve lung function. Budesonide nebulizer suspension and Budesonide inhalation suspension are two inhaled corticosteroids used in treating chronic obstructive pulmonary disorder (COPD). We compared the efficacy of Budesonide nebulizer suspension and Budesonide inhalation suspension in the treatment of patients with acute exacerbations of COPD, to prioritize the two treatments. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320566PMC
February 2018
2 Reads

Forced Expiratory Flow at 25-75% as a Marker for Airway Hyper Responsiveness in Adult Patients with Asthma-like Symptoms.

Tanaffos 2018 Feb;17(2):90-95

Air pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: The aim of the present study was threefold: to assess the association between baseline FEF and Airway Hyper-responsiveness (AHR), to specify whether a decrease in FEF may reflect severe hyper-responsiveness, and finally to confirm a FEF cut-off value.

Materials And Methods: In a cross sectional study in Imam Khomeini Hospital, Ahvaz, patients suffering from respiratory symptoms due the 2013 autumn rainfall with normal FEV1 and FEV1/FVC were evaluated by methacholine challenge test. Those with PD20<1000, 10002000 μg were classified as severe, moderate and mild AHR, respectively. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320556PMC
February 2018
4 Reads

Effect of Aerobic Exercises on Serum Levels of Apolipoprotein A1 and Apolipoprotein B, and Their Ratio in Patients with Chronic Obstructive Pulmonary Disease.

Tanaffos 2018 Feb;17(2):82-89

Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Cardiovascular disease is one of the most common disorders associated with chronic obstructive pulmonary disease (COPD). There are few studies on the effects of physical exercises, especially aerobic exercises, on serum levels of apolipoprotein A1 and apolipoprotein B in patients with COPD. The current study aimed at determining the effect of aerobic exercises on serum levels of apolipoprotein A1 and B and apo-A1/apo-B ratio. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320561PMC
February 2018
2 Reads

Reappraisal of Frequency of Common Cystic Fibrosis Transmembrane Conductance Regulator Gene Mutations in Iranian Cystic Fibrosis Patients.

Tanaffos 2018 Feb;17(2):73-81

Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Disease, (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Cystic Fibrosis (CF) is a life-threatening recessive genetic disorder resulting from mutations in the gene encoding the fibrosis transmembrane conductance regulator protein (CFTR). The CF clinical phenotype shows wide variation ranging from severe disease in early childhood in those homozygous for the p.Phe508del mutation to absence of the vas deferens in otherwise healthy men homozygous for the p. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320558PMC
February 2018
8 Reads

Immunologic Role of Extracellular Vesicles and Exosomes in the Pathogenesis of Cystic Fibrosis.

Tanaffos 2018 Feb;17(2):66-72

Pediatric Respiratory Disease Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran- Iran.

Cystic Fibrosis (CF) is the most common lethal autosomal recessive disease that affects many organs including, lung, pancreas and liver. Cystic fibrosis is a monogenic disease and occurs in the white Caucasians. Massive neutrophil granulocyte influx in the airways is one of the characteristics of CF. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320567PMC
February 2018
2 Reads

Community-Acquired Pneumonia with Negative Chest Radiography Findings: Clinical and Radiological Features.

Respiration 2019 Jan 9:1-10. Epub 2019 Jan 9.

Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.

Background: Data regarding community-acquired pneumonia (CAP) identified on chest computed tomography (CT) but not on chest radiography (CR) are limited.

Objectives: The present study aimed to investigate the clinical and radiological features of these patients.

Methods: We retrospectively compared the clinical characteristics, etiological agents, treatment outcomes, and CT findings between CAP patients with negative CR and positive CT findings (negative CR group) and those with positive CR as well as CT findings (control group). Read More

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http://dx.doi.org/10.1159/000495068DOI Listing
January 2019
5 Reads

Ensuring Basic Competence in Thoracentesis.

Respiration 2019 Jan 9:1-9. Epub 2019 Jan 9.

Copenhagen Academy for Medical Education and Simulation, The Capital Region of Denmark, Copenhagen, Denmark.

Background: Trocar pigtail catheter thoracentesis (TPCT) is a common procedure often performed by junior physicians. Simulation-based training may effectively train physicians in the procedure prior to performing it on patients. An assessment tool with solid validity evidence is necessary to ensure sufficient procedural competence. Read More

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https://www.karger.com/Article/FullText/495686
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http://dx.doi.org/10.1159/000495686DOI Listing
January 2019
7 Reads

Microbiological Progress in Patients with Bronchial Infection with Pseudomonas aeruginosa Treated with Nebulised Colistin.

Respiration 2019 Jan 3:1-7. Epub 2019 Jan 3.

Department of Medicine, Universitat Autònoma de Barcelona, Bellatera, Spain.

Background: Inhaled antibiotics allow the delivery of higher drug concentrations at the site of infection without the systemic adverse effects observed with the use of parenteral or oral antibiotics. These antibiotics have shown to decrease the number of exacerbations, reduce bacterial load or improve pulmonary function in several chronic respiratory conditions.

Objectives: The aim of this study was to describe changes in the bacteriology of sputum in patients with chronic bronchial infection with Pseudomonas aeruginosa treated with nebulised colistin. Read More

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https://www.karger.com/Article/FullText/495069
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http://dx.doi.org/10.1159/000495069DOI Listing
January 2019
2 Reads

Exploratory Study to Evaluate Respiratory Rate Using a Thermal Imaging Camera.

Respiration 2019 Jan 3:1-8. Epub 2019 Jan 3.

Faculty of ACES, Sheffield Hallam University, Sheffield, United Kingdom.

Background: Respiratory rate is a vital physiological measurement used in the immediate assessment of unwell children and adults. Convenient electronic devices exist for the measurement of pulse, blood pressure, oxygen saturation, and temperature. Although devices which measure respiratory rate exist, none have entered everyday clinical practice for acute assessment of children and adults. Read More

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http://dx.doi.org/10.1159/000490546DOI Listing
January 2019
2 Reads

Ultrathin Bronchoscopy with and without Virtual Bronchoscopic Navigation: Influence of Segmentation on Diagnostic Yield.

Respiration 2018 Dec 21:1-7. Epub 2018 Dec 21.

Department of Respiratory Medicine, University Hospital of Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), University of Barcelona, L'Hospitalet de Llobregat,

Background: Bronchoscopy is a safe technique for diagnosing peripheral pulmonary lesions (PPLs), and virtual bronchoscopic navigation (VBN) helps guide the bronchoscope to PPLs.

Objectives: We aimed to compare the diagnostic yield of VBN-guided and unguided ultrathin bronchoscopy (UTB) and explore clinical and technical factors associated with better results. We developed a diagnostic algorithm for deciding whether to use VBN to reach PPLs or choose an alternative diagnostic approach. Read More

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http://dx.doi.org/10.1159/000493270DOI Listing
December 2018
1 Read

Optimal Endobronchial Ultrasound Strain Elastography Assessment Strategy: An Explorative Study.

Respiration 2018 Dec 14:1-11. Epub 2018 Dec 14.

Department of Pulmonology, Radboud University Medical Center, Nijmegen, The

Background: In lung cancer staging, mediastinal lymph nodes are currently aspirated using endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) based on size and FDG-PET avidity. EBUS strain elastography (SE) is a new technique that may help predict the presence of malignancy. However, a standardized assessment strategy for EBUS-SE measurement is lacking. Read More

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http://dx.doi.org/10.1159/000494143DOI Listing
December 2018
1 Read

The REACH Trial: A Randomized Controlled Trial Assessing the Safety and Effectiveness of the Spiration® Valve System in the Treatment of Severe Emphysema.

Respiration 2018 Dec 14:1-12. Epub 2018 Dec 14.

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou,

Background: Chronic obstructive pulmonary disease (COPD) has become a leading cause of morbidity and mortality in China, with tobacco smoke, air pollution, and occupational biohazards being the major risk factors.

Objectives: The REACH trial is a multicenter, prospective, randomized controlled trial undertaken in China to assess the safety and effectiveness of the Spiration® Valve System (SVS) compared to standard medical care in COPD patients with severe emphysema.

Methods: Patients with severe airflow obstruction, hyperinflation, and severe dyspnea with interlobar fissure integrity were evaluated for enrollment. Read More

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http://dx.doi.org/10.1159/000494327DOI Listing
December 2018
2 Reads

Transbronchial Cryobiopsies for Diagnosing Interstitial Lung Disease: Real-Life Experience from a Tertiary Referral Center for Interstitial Lung Disease.

Respiration 2018 Dec 14:1-7. Epub 2018 Dec 14.

Center for Interstitial and Rare Lung Diseases, Thoraxklinik, University of Heidelberg, Heidelberg,

Background: Transbronchial cryobiopsy (cTBB) may offer an alternative to surgical lung biopsy (SLB) for histopathological diagnosis of interstitial lung diseases (ILDs). However, real-life experience is limited, although case series are increasingly reported.

Objectives: We aimed to evaluate the value of cTBB performed under real-life conditions in a tertiary care center for ILDs. Read More

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http://dx.doi.org/10.1159/000493428DOI Listing
December 2018
4 Reads

Nintedanib in Idiopathic Pulmonary Fibrosis: Practical Management Recommendations for Potential Adverse Events.

Respiration 2019 13;97(2):173-184. Epub 2018 Dec 13.

Department of Pulmonary Disease, Erasmus Medical Centre, University Hospital Rotterdam, Rotterdam, The Netherlands.

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a dismal survival rate of only 3 years and no curative pharmacological therapy. The recent approval of 2 anti-fibrotic drugs (nintedanib and pirfenidone) that slow disease progression has provided some hope for patients. However, effectively managing anti-fibrotic treatment can be a challenge due to tolerability issues, the presence of pulmonary and extra-pulmonary comorbidities, and the need for concomitant medications in many patients. Read More

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http://dx.doi.org/10.1159/000495046DOI Listing
December 2018
3 Reads

Catheter Tract Metastasis in Mesothelioma Patients with Indwelling Pleural Catheters: A Retrospective Cohort Study.

Respiration 2018 Dec 13:1-8. Epub 2018 Dec 13.

Division of Respirology, Department of Medicine, University of Ottawa, Ottawa, Ontario,

Background: Use of indwelling pleural catheters (IPCs) for the management of symptomatic pleural effusions in patients with mesothelioma has increased in popularity. An important concern with this approach is the potential for the development of catheter tract metastasis (CTM).

Objectives: To determine the incidence of IPC-related CTM in patients with malignant pleural mesothelioma (MPM). Read More

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https://www.karger.com/Article/FullText/494500
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http://dx.doi.org/10.1159/000494500DOI Listing
December 2018
8 Reads

Effect of Jet Nebulization on Noninvasive Positive-Pressure Ventilation Administered with Noninvasive or Intensive Care Unit Ventilators: A Bench Study.

Respiration 2018 Dec 13:1-8. Epub 2018 Dec 13.

Background: Most of the patients on noninvasive positive pressure ventilation require aerosol inhalation therapy to moisturize the airways or deliver drugs in acute settings. However, the effect of jet nebulization on noninvasive positive pressure ventilation (NPPV) has not been determined.

Objectives: This study was designed to investigate the impact of jet nebulization on NPPV applied in ventilators. Read More

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http://dx.doi.org/10.1159/000494456DOI Listing
December 2018
1 Read
2.593 Impact Factor

Let's Call It Lung Shock - Or Do We Use the Right Wording?

Respiration 2018 Dec 12:1-2. Epub 2018 Dec 12.

Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1159/000495256DOI Listing
December 2018
1 Read

Usual Interstitial Pneumonia Pattern in the Lower Lung Lobes as a Prognostic Factor in Idiopathic Pleuroparenchymal Fibroelastosis.

Respiration 2018 Dec 6:1-10. Epub 2018 Dec 6.

Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Background: Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a rare interstitial pneumonia that is characterized by stiffness in both the upper lobes and pleura, which is evident on high resolution computed tomography (HRCT) of the chest. However, prognostic factors for IPPFE have not been identified yet.

Objective: We aimed to investigate the clinical prognostic factors affecting survival in patients with IPPFE. Read More

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https://www.karger.com/Article/FullText/494061
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http://dx.doi.org/10.1159/000494061DOI Listing
December 2018
10 Reads

Obstructive Sleep Apnoea in Children and Adolescents with Ehlers-Danlos Syndrome.

Respiration 2018 Nov 28:1-8. Epub 2018 Nov 28.

Department of Pulmonology, University Hospital Zurich, Zurich,

Background: In Ehlers-Danlos syndrome (EDS), a group of monogenic disorders affecting connective tissues, obstructive sleep apnoea (OSA) is highly prevalent in adults. The prevalence of OSA in children with EDS is unknown.

Objectives: This prospective cross-sectional study aimed at determining the prevalence of OSA in paediatric EDS patients. Read More

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https://www.karger.com/Article/FullText/494328
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http://dx.doi.org/10.1159/000494328DOI Listing
November 2018
12 Reads

The Ratio Serum Creatinine/Serum Cystatin C (a Surrogate Marker of Muscle Mass) as a Predictor of Hospitalization in Chronic Obstructive Pulmonary Disease Outpatients.

Respiration 2018 Nov 27:1-8. Epub 2018 Nov 27.

Servicio Cántabro de Salud, Santander, Spain.

Background: In chronic obstructive pulmonary disease (COPD), low muscle mass has been associated with several clinical outcomes such as low exercise capacity, hospital admission, and mortality. The Sarcopenia Index (SI) is a novel way to estimate muscle mass based on the ratio of serum creatinine (produced exclusively by muscle)/cystatin C (produced by all nucleated body cells).

Objectives: This study aims to assess the SI in stable COPD outpatients, as compared with a healthy control group, to quantify its relationship with several important clinical features in COPD, and to study its potential usefulness to predict COPD exacerbations and hospital admissions. Read More

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http://dx.doi.org/10.1159/000494296DOI Listing
November 2018
1 Read

Health Outcomes for Definite Concurrent Chemoradiation in Locally Advanced Non-Small Cell Lung Cancer: A Prospective Study.

Respiration 2018 Nov 22:1-9. Epub 2018 Nov 22.

Department of Respiratory Medicine/Thoracic Oncology, Onze-Lieve-Vrouw Ziekenhuis Aalst, Aalst,

Background: In patients with locally advanced lung cancer treated with concurrent chemoradiation, outcome measurements have been mostly limited to survival.

Objectives: We aimed to measure outcomes that matter to these patients beyond survival in a general clinical practice.

Methods: In a prospective single-centre study, consecutive patients with locally advanced non-small cell lung cancer reported their own outcomes using the EORTC Quality of Life Questionnaire Core 30 at baseline, during therapy, at therapy stop and till 1 year after therapy end every 3 months. Read More

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http://dx.doi.org/10.1159/000493984DOI Listing
November 2018
10 Reads

Confocal Laser Endomicroscopy as a Guidance Tool for Transbronchial Lung Cryobiopsies in Interstitial Lung Disorder.

Respiration 2018 Nov 14:1-5. Epub 2018 Nov 14.

Department of Respiratory Medicine, Amsterdam University Medical Centers, Amsterdam, The

Background: Transbronchial cryobiopsy (TBCB) of the lung parenchyma is a minimally invasive alternative for surgical lung biopsy in interstitial lung disease (ILD) patients. Drawbacks are the nondiagnostic rate and complication risk of pneumothorax and bleeding. Fluoroscopy is the current guidance tool for TBCB, which is limited by 2D imaging and a radiation dose for the patient. Read More

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https://www.karger.com/Article/FullText/493271
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http://dx.doi.org/10.1159/000493271DOI Listing
November 2018
9 Reads

The Pathophysiology of Respiratory Failure: Control of Breathing, Respiratory Load, and Muscle Capacity.

Respiration 2019 13;97(2):93-104. Epub 2018 Nov 13.

Division of Lung Diseases, University Hospitals of Geneva and Geneva Medical School, Geneva, Switzerland.

The purpose of this review is to provide an overview on how interactions between control of breathing, respiratory load, and muscle function may lead to respiratory failure. The mechanisms involved vary according to the underlying pathology, but respiratory failure is most often the result of an imbalance between the muscular pump and the mechanical load placed upon it. Changes in respiratory drive and response to CO2 seem to be important contributors to the pathophysiology of respiratory failure. Read More

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https://www.karger.com/Article/FullText/494063
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http://dx.doi.org/10.1159/000494063DOI Listing
November 2018
15 Reads

Increased Risk for Cancer in Young Patients with Severe Obstructive Sleep Apnea.

Respiration 2019 12;97(1):15-23. Epub 2018 Nov 12.

Ben-Gurion University, Beer-Sheva,

Background: Several studies in animal models and human with obstructive sleep apnea syndrome (OSAS) demonstrated an increase in cancer aggressiveness and mortality. However, there is a need for further clinical evidence supporting a correlation between OSAS and cancer incidence.

Objectives: To reveal whether OSAS presence and severity is correlated with cancer incidence in a large homogenous patients' cohort. Read More

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https://www.karger.com/Article/FullText/486577
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http://dx.doi.org/10.1159/000486577DOI Listing
November 2018
16 Reads

Comparison of Nocturnal Cough Analysis in Healthy Subjects and in Patients with Cystic Fibrosis and Primary Ciliary Dyskinesia: A Prospective Observational Study.

Respiration 2019 8;97(1):60-69. Epub 2018 Nov 8.

Pediatric Respiratory Medicine Unit, Department of General Pediatrics, University Hospital Münster, Münster,

Background: Cough is a key symptom in patients with cystic fibrosis (CF) and primary ciliary dyskinesia (PCD).

Objective: The study objectives were to test whether cough is related to parameters reflecting their disease severity and whether CF and PCD differ in cough frequency.

Methods: In this prospective observational study, we used a microphone-based monitoring system (LEOSound® Monitor) to count the coughs in healthy subjects (HS) and in stable patients with CF and PCD (25 subjects per group) on 2 consecutive nights. Read More

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http://dx.doi.org/10.1159/000493323DOI Listing
November 2018
12 Reads

Hospital Volume and Mortality following Diagnostic Bronchoscopy in Lung Cancer Patients: Data from a National Inpatient Database in Japan.

Respiration 2018 Nov 8:1-9. Epub 2018 Nov 8.

Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: Recent advances in bronchoscopy utilizing endobronchial ultrasound (EBUS) as well as lung cancer therapy may have driven physicians to perform diagnostic bronchoscopy (DB) for high-risk patients.

Objectives: The aim of this study was to clarify the relationship between hospital volume (HV) and outcomes of DB.

Methods: We collected data on inpatients with lung cancer who underwent DB from July 2010 to March 31, 2014. Read More

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https://www.karger.com/Article/FullText/493859
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http://dx.doi.org/10.1159/000493859DOI Listing
November 2018
8 Reads

Primary Tracheal Mucosa-Associated Lymphoid Tissue Lymphoma Treated with a Water-Jet Hybrid Knife: A Case Report.

Respiration 2019 8;97(2):168-172. Epub 2018 Nov 8.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing,

Primary mucosa-associated lymphoid tissue (MALT) lymphoma of the trachea is very rare and is easily misdiagnosed as a bronchogenic carcinoma or benign tracheal tumor. Here, we report a clinical case where a new clinical approach involving a water-jet hybrid knife was employed in the diagnosis and treatment of primary tracheal MALT lymphoma. Read More

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https://www.karger.com/Article/FullText/494064
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November 2018
6 Reads

Developing and Gathering Validity Evidence for a Simulation-Based Test of Competencies in Lung Ultrasound.

Respiration 2018 Nov 7:1-8. Epub 2018 Nov 7.

Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark.

Background: Clinical lung ultrasound (LUS) is a fast bedside diagnostic tool which can assist clinicians in decisions regarding the treatment and monitoring of patients with respiratory symptoms. LUS training and education differ widely, and is often done in a clinical setting, with potential risks for patients if decisions are made based on the wrong interpretations. No clear guidelines or recommendations for objective and standardized assessment of LUS skills exist, and those that do are often based on a fixed time-frame or an arbitrary number of examinations performed; this does not ensure adequate competencies. Read More

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November 2018
14 Reads

Doc, I Have COPD: Will I Tolerate Moderate-High Altitude?

Respiration 2019 7;97(2):105-107. Epub 2018 Nov 7.

Department of Internal Medicine, Pneumology Unit, Regional Hospital, Locarno,

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http://dx.doi.org/10.1159/000493861DOI Listing
November 2018
2 Reads

Simulation-Based Mastery Learning of Flexible Bronchoscopy: Deciding Factors for Completion.

Respiration 2019 2;97(2):160-167. Epub 2018 Nov 2.

Copenhagen Academy for Medical Education and Simulation (CAMES), Copenhagen, Denmark.

Background: Several studies have shown the beneficial effects of mastery learning of a simulation-based course, but not all trainees complete it.

Objectives: The purpose of this study was to find deciding factors for the completion of a simulation-based mastery learning course with distributive practice in flexible bronchoscopy.

Methods: Seventy-seven trainees who signed up for the course were invited to a survey for deciding factors of completing the course. Read More

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http://dx.doi.org/10.1159/000493431DOI Listing
November 2018
1 Read

Patient Satisfaction and Clinical Outcomes with Budesonide plus Formoterol Spiromax for Asthma and Chronic Obstructive Pulmonary Disease: A Real-World, Observational Trial.

Respiration 2018 Nov 2:1-10. Epub 2018 Nov 2.

Cologne Merheim Hospital, Witten/Herdecke University, Cologne, Germany.

Background: The fixed-dose combination of budesonide/formoterol (B/F) has been available in the Spiromax® dry powder inhaler since 2014.

Objectives: To assess patient satisfaction, inhaler use errors, and disease control in patients with asthma or chronic obstructive pulmonary disease (COPD) treated with B/F Spiromax.

Methods: This non-interventional, prospective, 12-week study enrolled consecutive asthma or COPD patients who had recently begun treatment with B/F Spiromax or were switched from another inhaled corticosteroid/long-acting β2-agonist combination to B/F Spiromax in routine clinical practice. Read More

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November 2018
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Non-Invasive Ventilation as an Adjunct to Exercise Training in Chronic Ventilatory Failure: A Narrative Review.

Respiration 2019 31;97(1):3-11. Epub 2018 Oct 31.

Istituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Institute of Montescano (PV), Montescano, Italy.

Background: Chronic ventilatory failure (CVF) may be associated with reduced exercise capacity. Long-term non-invasive ventilation (NIV) may reduce patients' symptoms, improve health-related quality of life and reduce mortality and hospitalisations. There is an increasing use of NIV during exercise training with the purpose to train patients at intensity levels higher than allowed by their pathophysiological conditions. Read More

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http://dx.doi.org/10.1159/000493691DOI Listing
October 2018
2 Reads

Closure of Bronchopleural Fistula with Mesenchymal Stem Cells: Case Report and Brief Literature Review.

Respiration 2018 Oct 26:1-4. Epub 2018 Oct 26.

Department of Pulmonary and Critical Care Medicine, the Second Affiliated Hospital of Fujian Medical University, the Second Clinical Medical College of Fujian Medical University, Center of Respiratory Medicine of Fujian Province, Quanzhou, China.

Closure of bronchopleural fistula remains a difficult challenge for clinicians. Although several therapeutic approaches have been proposed, the clinical results are commonly unsatisfactory. Previous reports have indicated that autologous mesenchymal stem cells (MSCs) are useful for aiding treatment of bronchopleural fistula. Read More

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https://www.karger.com/Article/FullText/493757
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October 2018
10 Reads

When the Heart Steals Your Breath Away.

Respiration 2018 Oct 25:1-3. Epub 2018 Oct 25.

COPD Center, Institute of Medicine, Sahlgrenska University Hospital, Gothenburg University, Gothenburg, Sweden.

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https://www.karger.com/Article/FullText/493760
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October 2018
8 Reads

Real-Time PCR Detection of the Basidiomycetous Fungus Bjerkandera adusta: A Tool to Identify Itraconazole Responder Patients with Unexplained Chronic Cough.

Respiration 2019 19;97(1):84-91. Epub 2018 Oct 19.

Graduate School of Medicine, Teikyo University, Tokyo,

Background: Filamentous basidiomycetes (f-BMs) are involved in some unexplained chronic cough (UCC) cases that can be improved by the administration of antifungal agents. The disease concept was termed fungus-associated chronic cough (FACC). The current diagnostic criteria warrant environmental fungi isolation from respiratory specimens, which is hardly conceivable for such fungi. Read More

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http://dx.doi.org/10.1159/000492118DOI Listing
October 2018
2 Reads