5,623 results match your criteria Respiration[Journal]


The Impact of Continuous Positive Airway Pressure upon Pleural Fluid Pressures during Thoracentesis.

Respiration 2019 Apr 17:1-5. Epub 2019 Apr 17.

University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA.

Background: Excessive drop of pleural pressure (Ppl) during therapeutic thoracentesis may be related to adverse events and/or to repeated procedures due to incomplete drainage.

Objective: This was a pilot study of the impact of the application of continuous positive airway pressure (CPAP) at +5 cm H2O upon the Ppl profile during thoracentesis.

Methods: This was a prospective, controlled study of 49 consecutive adults who underwent thoracentesis. Read More

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http://dx.doi.org/10.1159/000496610DOI Listing
April 2019
2 Reads

Delays in the Diagnosis and Treatment of Tuberculous Lymphadenitis in Low-Incidence Countries: A Systematic Review.

Respiration 2019 Apr 17:1-9. Epub 2019 Apr 17.

Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.

Early detection and treatment of tuberculosis (TB) is essential to achieve the goals appointed in the WHO End TB Strategy. Tuberculous lymphadenitis (TBLA) is the most common manifestation of extrapulmonary TB, but the diagnosis can be challenging in low-incidence countries due to sparse and inconsistent clinical features, resulting in delay. We aimed to summarize and discuss the current literature on patient delay, health care delay, and total delay (i. Read More

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http://dx.doi.org/10.1159/000499052DOI Listing

A Trained Pulmonologist Can Reliably Assess Endosonography-Derived Lymph Node Samples during Rapid On-Site Evaluation.

Respiration 2019 Apr 12:1-9. Epub 2019 Apr 12.

Interventional Pulmonology Unit, Policlinico Sant'Orsola-Malpighi and Ospedale Maggiore, Bologna, Italy,

Background: The widespread use of rapid on-site evaluation is hampered by constraints related to time and resources, inadequate reimbursement, and evidence from randomized trials that show a lack of increase in diagnostic yield and specimen adequacy associated with its usage.

Objective: We aimed to verify whether a pulmonologist can assess endosonography-derived lymph node samples after a comprehensive and reproducible training provided by a specialist pathologist.

Methods: Prospective, observational trial structured in three phases. Read More

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http://dx.doi.org/10.1159/000496549DOI Listing
April 2019
1 Read

Interventional Bronchoscopy for the Treatment of Malignant Central Airway Stenosis: An Expert Recommendation for China.

Respiration 2019 Apr 10:1-11. Epub 2019 Apr 10.

Department of Respiratory Medicine, Meitan General Hospital, Beijing, China.

Malignant central airway stenosis refers to airway stenosis caused by primary or metastatic malignant tumors which may lead to different levels of dyspnea or asphyxia in patients. With the rapid development of interventional pulmonology, therapeutic bronchoscopy has become one of the main methods for the diagnosis and treatment of malignant central airway stenosis. However, the level of diagnosis and treatment of respiratory intervention techniques in China is uneven at present, the treatment methods are not uniform, the treatment effects vary greatly, and some treatments even lead to serious complications. Read More

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http://dx.doi.org/10.1159/000497213DOI Listing

A 2-Year Observational Study in Patients Suffering from Idiopathic Pulmonary Fibrosis and Treated with Pirfenidone: A French Ancillary Study of PASSPORT.

Respiration 2019 Apr 9:1-10. Epub 2019 Apr 9.

Pulmonology Department, National Coordinating Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, University Claude Bernard Lyon 1, Lyon, France.

Background: The European observational, prospective PASSPORT study evaluated the long-term safety of pirfenidone under real-world conditions in idiopathic pulmonary fibrosis (IPF), over up to 2 years following its initiation.

Objectives: The FAS (French Ancillary Study) assessed the clinical outcomes of IPF patients participating in PASSPORT (n = 192).

Methods: Efficacy data were collected retrospectively and prospectively. Read More

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http://dx.doi.org/10.1159/000496735DOI Listing
April 2019
4 Reads

A New-Designed Lung-Bending Device for Bronchoscopic Lung Volume Reduction of Severe Emphysema: A Feasibility Study in Pigs.

Respiration 2019 Apr 4:1-7. Epub 2019 Apr 4.

Department of Respiratory and Critical Care Medicine of Peking University First Hospital, Beijing, China,

Background: Bronchoscopic therapies are less invasive alternatives of surgical lung volume reduction for severe emphysema. Bending of lung tissue by implanting metallic coils into bronchi is one of the procedures. A new-designed device with a similar rationale, Reverser, has been developed with some improvements. Read More

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http://dx.doi.org/10.1159/000495142DOI Listing
April 2019
3 Reads

Safety and Efficacy of Early and Long-Term Use of Pirfenidone in Idiopathic Pulmonary Fibrosis.

Respiration 2019 Apr 4:1-3. Epub 2019 Apr 4.

First Academic Department of Pneumonology, Sotiria General Hospital for Chest Diseases, National and Kapodistrian University of Athens School of Medicine, Athens, Greece,

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http://dx.doi.org/10.1159/000497391DOI Listing
April 2019
1 Read

Muddied Waters: Echogenic Pleural Transudates Do Exist!

Respiration 2019 Apr 3:1-3. Epub 2019 Apr 3.

Division of Pulmonology, Department of Medicine, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa,

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https://www.karger.com/Article/FullText/496706
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http://dx.doi.org/10.1159/000496706DOI Listing
April 2019
8 Reads

Similar Airway Function after Volitional Hyperpnea in Mild-Moderate Asthmatics and Healthy Controls.

Respiration 2019 Apr 1:1-11. Epub 2019 Apr 1.

Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich, Zurich, Switzerland,

Background: The beneficial effects of exercise training for asthmatics might relate to repetitive airway stretching. Thus, a training with more pronounced airway stretch using isolated, volitional hyperpnea (HYP) might be similarly or more effective. However, in healthy subjects, a bout of HYP training is known to cause an acute FEV1 decline. Read More

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http://dx.doi.org/10.1159/000496028DOI Listing
April 2019
1 Read

Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency.

Respiration 2019 Mar 29:1-4. Epub 2019 Mar 29.

Center for Interstitial and Rare Lung Diseases, Thoraxklinik at University of Heidelberg, Heidelberg, Germany,

GATA2 deficiency is characterized by monocytopenia, deficiency of dendritic cells, and a variable degree of lymphocytopenia affecting B cells and NK cells, leading to an enhanced risk of mycobacterial, viral, and fungal infections. Here we present a patient with a heterozygous intronic GATA2 mutation who acquired a fatal disseminated mycosis due to the black yeast-like fungus Arthrocladium fulminans following an infection with Mycobacterium sherrisii. This case illustrates that in patients with severe uncommon infections, immunodeficiency syndromes must be ruled out. Read More

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http://dx.doi.org/10.1159/000493429DOI Listing
March 2019
1 Read

Utility of Anti-DSF70 Antibodies to Predict Connective Tissue Disease in Patients Originally Presenting with Idiopathic Interstitial Pneumonia.

Respiration 2019 Mar 29:1-9. Epub 2019 Mar 29.

Center for Interstitial and Rare Lung Diseases, Department of Pneumology, Ruhrlandklinik University Hospital, University of Duisburg-Essen, Essen, Germany,

Background: Anti-DFS70 antibodies, corresponding to the dense fine speckled antinuclear antibody (ANA) pattern in HEp-2 substrates, have been observed in chronic inflammatory conditions, cancer and in healthy individuals but in only a small percentage of patients with connective tissue diseases (CTD).

Objectives: The study was aimed to investigate the possible role of Anti-DFS70 antibodies to distinguish CTD associated interstitial lung disease (CTD-ILD) from idiopathic interstitial pneumonia (IIP) and to explore potential correlations between anti-DFS70 antibodies and clinical parameters.

Methods: Serum samples were collected from 49 healthy controls (HC), 35 scleroderma-ILD (SSc-ILD) patients as negative controls for anti-DFS70 antibody, and 260 patients with the initial diagnosis IIP including 100 nonspecific interstitial pneumonia (NSIP) and 160 idiopathic pulmonary fibrosis (IPF) patients. Read More

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http://dx.doi.org/10.1159/000496483DOI Listing
March 2019
3 Reads

Clinical and Economic Benefits of Upper Airway Stimulation for Obstructive Sleep Apnea in a European Setting.

Respiration 2019 Mar 28:1-10. Epub 2019 Mar 28.

Institute for Health Care Management and Research, University of Duisburg-Essen, Essen, Germany.

Background: Upper airway stimulation (UAS) is a treatment approach for patients with moderate-to-severe obstructive sleep apnea who cannot adhere to continuous positive airway pressure therapy.

Objective: The objective was to evaluate added patient benefit and cost-effectiveness of UAS in the German health care system.

Methods: We used a decision-analytic Markov model to project major adverse cardiovascular or cerebrovascular events (myocardial infarction [MI] or stroke), motor vehicle collision (MVC), mortality, quality-adjusted life years (QALYs), and costs. Read More

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http://dx.doi.org/10.1159/000497101DOI Listing
March 2019
2 Reads

Spinal Anesthesia for Renal Transplantation in Lung Resected Patient: A Case Report.

Tanaffos 2018 Mar;17(3):207-210

Department of Anesthesiology, Loghman Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Renal transplantation is among the definitive therapies for treatment of patients with "End-Stage Renal Disease" (ESRD). Proper anesthesia should be considered in patients who undergo renal transplantation. On the other hand, anesthesia in patients with single lung is an ever challenging issue. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428382PMC
March 2018
1 Read

Caspofungin as Salvage Therapy for Pneumocystis Pneumonia in a Heart Transplant Recipient.

Tanaffos 2018 Mar;17(3):203-206

Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pneumocystis pneumonia (PCP) is a common opportunistic infection in immunocompromised patients. In general, clinical response to therapy with cotrimoxazole is excellent. However, therapy may be limited by side effects or treatment failure. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428377PMC
March 2018
4 Reads

Designing and Construction of a Cloning Vector Containing Gene of .

Tanaffos 2018 Mar;17(3):198-202

Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Tuberculosis caused by , remains as one of the leading causes of deaths worldwide, with nearly two million death cases annually. BCG (Bacille Calmette-Guerin) continues to be the most widely used vaccine in the world, but the protective immunity differs in different parts of the world. Accordingly, new strategies including DNA vaccines are essentially needed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428376PMC

Impact of HIV Co-Infection on Clinical Presentation in Patients with TB and Correlation of the Findings with Level of Immune Suppression.

Tanaffos 2018 Mar;17(3):188-197

Department of Respiratory Medicine, R N T Medical College, Udaipur (Raj.), India.

Background: The Human Immunodeficiency Virus (HIV) has long been known to alter the clinical presentation of tuberculosis (TB), which varies according to the time of occurrence of TB infection and the level of immunodeficiency. Identifying variations in clinical features in HIV-TB coinfection might be helpful in settings with limited diagnostic facilities. The aim of this study was to assess the clinical presentation of TB in HIV coinfection and associate clinical findings with level of immune suppression (CD4 count). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428384PMC

Study Protocol on Antimicrobial Stewardship in a Tertiary Respiratory Referral Hospital.

Tanaffos 2018 Mar;17(3):183-187

Clinical Tuberculosis and Epidemiology Research Center, NIRTLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Antimicrobial stewardship program is a comprehensive, longitudinal program designed to improve and measure the appropriateness of antimicrobial use while increasing patients' safety, decreasing cost of patients' care, and combating emerging antimicrobial resistance. Antimicrobial resistance, specially emerging multidrug-resistance and extremely drug-resistance gram negative bacteria, is an important concern in the modern world. This is particularly problematic since antimicrobials in production pipelines are not meeting the demand for the emerging resistance micro-organisms; in another word "we are running out of options". Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428375PMC

Effect of Diaphragm Plication in Thymoma Patients with and without Myasthenia Gravis.

Tanaffos 2018 Mar;17(3):177-182

Lung Disease Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Thymoma is the most common tumor of the anterior mediastinum that has the most effective treatment, as it can be completely resected. In patients with advanced stage, phrenic nerve involvement can be seen and suggested treatment for these patients is unilateral phrenic excision and diaphragm plication. However in patients with myasthenia gravis, there are concerns in relation to this method of treatment. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428380PMC
March 2018
1 Read

Causes of Deceased Donors Loss before Organ Retrieval.

Tanaffos 2018 Mar;17(3):172-176

Lung Transplantation Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: When potential brain dead donors are in line-up for organ retrieval, their loss would be such a disaster. The aim of this study was to detect the occurrence of different disorders leading to pre-retrieval donor's cardiac arrest and loss in order to prevent this energy and money wasting challenge.

Materials And Methods: In this observational study, medical records of potential donors from 2001 to 2016 who were lost after transfer to Organ Procurement Unit (OPU) of Masih Daneshvari Hospital and before organ donation were reviewed and weigh of every responsible disorder was tested. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428383PMC
March 2018
1 Read

Effect of Salmeterol-Fluticasone Combination and Tiotropium on Clinical and Physiological Improvement of Bronchial Anthracofibrosis: a Double Blind Randomized, Cross Over, Placebo Controlled, Clinical Trial.

Tanaffos 2018 Mar;17(3):163-171

Department of Urology, Akbar Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Bronchial anthracosis is the black discoloration of bronchial mucosa that exhibits similar manifestations to Chronic Obstructive Pulmonary Disease ( COPD). The etiology of this obstructive lung disease has not been elucidated and standard therapy for this disease has not been introduced in the literature. The objective of this study is to determine the efficacy of the salmeterol-fluticasone inhaler and tiotropium as two safe treatments of obstructive lung disease for the treatment of symptomatic subjects of anthracofibrosis of the lung. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428379PMC
March 2018
3 Reads

Comparison of Therapeutic Approaches to Addicted Patients with Central Sleep Apnea.

Tanaffos 2018 Mar;17(3):155-162

Department of Cardiology and Pulmonology, Center of Sleep Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Nowadays, the most practical approaches used to treat sleep apnea, are Continuous Positive Airway Pressure (CPAP), Bi-level Positive Airway Pressure therapy (BPAP), supplemental O, servoventilation and/or a combination of these approaches simultaneously. However, each leads to different consequences in opioid related Central Sleep Apnea (CSA) patients. Given the high prevalence of CSA and frequently use of opioids worldwide, it seems that evaluation of the condition in these patients is required to determine their responsiveness to the above mentioned treatments and to choose the most appropriate therapy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428378PMC
March 2018
1 Read

The Study of and Genes Expression in Patients with Different Stages of Asthma: a Case-Control Study.

Tanaffos 2018 Mar;17(3):146-154

Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.

Background: Asthma is considered as a complex disorder in which genetics and environment play crucial role in its susceptibility. In addition to the huge financial costs that significantly reduce the quality of life of the patients and their families, it causes high prevalence of lung diseases. Finding contributing new genetic factors involved in early diagnosis or progression of asthma can provide novel approaches for treatment or managing of asthma. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428381PMC
March 2018
2 Reads

Management of Persistent Air Leaks Using Endobronchial Autologous Blood Patch and Spigot Occlusion: A Multicentre Randomized Controlled Trial in China.

Respiration 2019 Mar 22:1-8. Epub 2019 Mar 22.

Department of Respiration, Tangdu Hospital, Air Force Military Medical University, Xi'an, China,

Background: Optimal management of persistent air leaks (PALs) in patients with secondary spontaneous pneumothorax (SSP) remains controversial.

Objective: To evaluate the efficacy and safety of endobronchial autologous blood plus thrombin patch (ABP) and bronchial occlusion using silicone spigots (BOS) in patients with SSP accompanied by alveolar-pleural fistula (APF) and PALs.

Methods: This prospective multicentre randomized controlled trial compared chest tube-attached water-seal drainage (CTD), ABP, and BOS that were performed between February 2015 and June 2017 in one of six tertiary care hospitals in China. Read More

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http://dx.doi.org/10.1159/000495298DOI Listing
March 2019
3 Reads

Prospective Analysis of the Predictive Value of Sonographic Pleural Fluid Echogenicity for the Diagnosis of Exudative Effusion.

Respiration 2019 Mar 19:1-6. Epub 2019 Mar 19.

Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.

Background: Pleural effusion echogenicity on ultrasound has previously been suggested to allow identification of exudates. A case series suggested that homogenously echogenic effusions are always exudates. With modern imaging techniques and more advanced ultrasound technology, this may no longer be true. Read More

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http://dx.doi.org/10.1159/000496153DOI Listing
March 2019
1 Read

COPD: Rethinking Patient Management - How to Approach a Challenging Patient Group Successfully.

Respiration 2019 Mar 15;97(4):363-368. Epub 2019 Mar 15.

Clinic for Pneumology and Allergology, Centre of Sleep Medicine and Respiratory Care, Bethanien Hospital, Institute of Pneumology, University of Cologne, Solingen, Germany.

In comparison to other chronically ill people, patients suffering from chronic obstructive pulmonary disease (COPD) have many additional difficulties to face and conquer. Due to the contribution of avoidable causes of their illness ("smokers' lung"), society holds people with COPD responsible for their disease, which in return often leads to stigmatization and social isolation. In addition, COPD patients commonly belong to a less privileged social class, own a low socioeconomic status, and lower education. Read More

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http://dx.doi.org/10.1159/000493759DOI Listing
March 2019
2 Reads

Is the Metronome-Paced Tachypnea Test (MPT) Ready for Clinical Use? Accuracy of the MPT in a Prospective and Clinical Study.

Respiration 2019 Mar 14:1-7. Epub 2019 Mar 14.

Pulmonary Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands.

Background: A simple technique to measure dynamic hyperinflation (DH) in patients with chronic obstructive pulmonary disease (COPD) is the metronome-paced tachypnea test (MPT). Earlier studies show conflicting results about the accuracy of the MPT compared to cardiopulmonary exercise testing (CPET).

Objectives: The focus was to investigate the diagnostic accuracy of MPT to detect DH in a prospective and clinical study. Read More

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http://dx.doi.org/10.1159/000496290DOI Listing
March 2019
1 Read

Endoscopic Lung Volume Reduction: An Expert Panel Recommendation - Update 2019.

Respiration 2019 Mar 5:1-10. Epub 2019 Mar 5.

Division of Pulmonary and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Endoscopic lung volume reduction (ELVR) therapies are gaining prominence as a treatment option with guideline recommendations by COPD GOLD and NICE and the recent FDA approval for endobronchial valves. The transition from an experiment-based therapy only to clinical care comes with new challenges. A significant volume of evidence-based data has been published; all data demonstrate consistent improvements in several aspects of patient outcomes. Read More

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http://dx.doi.org/10.1159/000496122DOI Listing
March 2019
6 Reads

Simplified Criteria Using Pleural Fluid Cholesterol and Lactate Dehydrogenase to Distinguish between Exudative and Transudative Pleural Effusions.

Respiration 2019 Mar 1:1-7. Epub 2019 Mar 1.

Université de Sherbrooke, Hôpital Charles-Lemoyne, Greenfield Park, Québec, Canada.

Background: An important part of the investigation of pleural effusion is the identification of markers that help separate exudate from transudate.

Objectives: The purposes of this study were to compare the accuracy of published and new sets of criteria to distinguish between exudative and transudative pleural effusions, and to determine whether serum biochemical analysis is necessary.

Methods: An externally validated cohort study was performed. Read More

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http://dx.doi.org/10.1159/000496396DOI Listing
March 2019
3 Reads

A Design-Based Stereologic Method to Quantify the Tissue Changes Associated with a Novel Drug-Eluting Tracheobronchial Stent.

Respiration 2019 Feb 20:1-10. Epub 2019 Feb 20.

Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA,

Background: Granulation tissue is a common complication of airway stenting, but no published methods can quantify the volume and type of tissue that develops.

Objective: To use design-based stereology to quantify changes in tissue volume and type associated with airway stenting.

Methods: We compared drug-eluting stents (DES) filled with gendine to standard silicone stents in pigs in an assessor-blinded randomized trial. Read More

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https://www.karger.com/Article/FullText/496152
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http://dx.doi.org/10.1159/000496152DOI Listing
February 2019
5 Reads

The Cryoablation for Peripheral Pulmonary Lesions Using a Novel Flexible Bronchoscopic Cryoprobe in the ex vivo Pig Lung and Liver.

Respiration 2019 Feb 21:1-6. Epub 2019 Feb 21.

Department of Endoscopy, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China,

Background: Percutaneous cryoablation has been used for the treatment of lung cancer and has been shown to be safe and effective. However, some lung cancer lesions cannot be reached by percutaneous puncture; using bronchoscopy cryoablation is necessary in these cases.

Purposes: To examine the efficiency and security of a flexible cryoprobe, we measured the size and temperature distribution of the frozen area (ice ball) in ex vivo pig lung and liver and the temperature of the bronchoscope. Read More

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http://dx.doi.org/10.1159/000494142DOI Listing
February 2019
2 Reads

Effects of Breath-Hold Deep Diving on the Pulmonary System.

Respiration 2019 Feb 15:1-8. Epub 2019 Feb 15.

Department of Sports Medicine, Medical Clinic, Eberhard Karls University of Tübingen, Tübingen, Germany.

This short review focuses on pulmonary injury in breath-hold (BH) divers. When practicing their extreme leisure sport, they are exposed to increased pressure on pulmonary gas volumes, hypoxia, and increased partial gas pressures. Increasing ambient pressures do present a serious problem to BH deep divers, because the semi-rigid thorax prevents the deformation required by the Boyle-Mariotte law. Read More

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http://dx.doi.org/10.1159/000495757DOI Listing
February 2019
1 Read

Diff-Quik Cytology Smears from Endobronchial Ultrasound Transbronchial Needle Aspiration Lymph Node Specimens as a Source of DNA for Next-Generation Sequencing Instead of Cell Blocks.

Respiration 2019 Feb 7:1-14. Epub 2019 Feb 7.

Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

Background: Next-generation sequencing (NGS) in lung cancer specimens from endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) is usually performed on formalin-fixed paraffin-embedded cell block material.

Objectives: Since DNA can be damaged by this process, we investigated the potential of using DNA extracted from Diff-Quik cytology smears made for rapid on-site evaluation during EBUS-TBNA.

Methods: In a prospective study, 67 patients undergoing diagnostic EBUS-TBNA were ana-lysed. Read More

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http://dx.doi.org/10.1159/000495661DOI Listing
February 2019

Long-Term Ventilation in Neuromuscular Patients: Review of Concerns, Beliefs, and Ethical Dilemmas.

Respiration 2019 24;97(3):185-196. Epub 2019 Jan 24.

Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Palermo, Italy.

Background: Noninvasive mechanical ventilation (NIV) is an effective treatment in patients with neuromuscular diseases (NMD) to improve symptoms, quality of life, and survival.

Summary: NIV should be used early in the course of respiratory muscle involvement in NMD patients and its requirements may increase over time. Therefore, training on technical equipment at home and advice on problem solving are warranted. Read More

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http://dx.doi.org/10.1159/000495941DOI Listing
January 2019
24 Reads

Prevalence and Factors Contributing to Daytime and Nocturnal Hypoxemia in Chronic Heart Failure Patients.

Respiration 2019 17;97(3):213-222. Epub 2019 Jan 17.

Laboratoire HP2, INSERM U 1042, Grenoble Alpes University, Grenoble, France.

Background: Despite clinical optimization, many chronic heart failure (CHF) patients remain symptomatic with dyspnea and poor quality of life.

Study Objective: While oxygen therapy is prescribed in severe cases, the actual prevalence of different patterns of hypoxemia is unknown.

Methods: We analyzed 183 stable CHF patients with optimized medical treatment in the "MARS" database. Read More

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http://dx.doi.org/10.1159/000490734DOI Listing
January 2019
3 Reads

Can Early Introduction of Palliative Care Limit Intensive Care, Emergency and Hospital Admissions in Patients with Severe Chronic Obstructive Pulmonary Disease? A Pilot Randomized Study.

Respiration 2019 Jan 16:1-10. Epub 2019 Jan 16.

Department of Community Medicine, Primary Care, and Emergency, Geneva University Hospitals, Geneva, Switzerland.

Background: Despite their poor prognosis, patients with severe chronic obstructive pulmonary disease (COPD) have little access to palliative care and tend to have a high rate of hospital and intensive care unit (ICU) admissions during their last year of life.

Objectives: To determine the feasibility of a home palliative care intervention during 1 year versus usual care, and the possible impact of this intervention on emergency, hospital and ICU admissions, survival, mood, and health-related quality of life (HRQL).

Methods: Prospective controlled study of patients with severe COPD (GOLD stage III or IV) and long-term oxygen therapy and/or home noninvasive ventilation and/or one or more hospital admissions in the previous year for acute exacerbation, randomized to usual care versus usual care with add-on monthly intervention by palliative care specialists at home for 12 months. Read More

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http://dx.doi.org/10.1159/000495312DOI Listing
January 2019
4 Reads

Acute Respiratory Distress Syndrome following Cardiac Surgery: Comparison of the American-European Consensus Conference Definition versus the Berlin Definition.

Respiration 2019 Jan 16:1-7. Epub 2019 Jan 16.

Department of Cardiac Surgery, Sheba Medical Center (affiliated to the Sackler School of Medicine, Tel Aviv University), Tel Hashomer, Israel.

Background: Lung injury with development of the acute respiratory distress syndrome (ARDS) is a serious complication which can occur after major surgery, including cardiac surgery.

Objective: The aim of our study was to compare the prevalence, risk factors, and mortality of ARDS following cardiac surgery according to the American-European Consensus Conference (AECC) definition and the new Berlin definition of ARDS.

Methods: We performed a retrospective, observational study that included prospectively collected data from consecutive adult patients, aged from 18 to 92 years, who had undergone cardiac surgery (both on and off pump) at a large tertiary university hospital over 5 years (from September 2012 to September 2017). Read More

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https://www.karger.com/Article/FullText/495511
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http://dx.doi.org/10.1159/000495511DOI Listing
January 2019
14 Reads

Chronic Eosinophilic Pneumonia with Cardiac Involvement.

Tanaffos 2018 Feb;17(2):142-145

Department of Cardiology, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Chronic Eosinophilic Pneumonia (CEP) is an idiopathic disorder characterized by an abnormal marked accumulation of eosinophils in the interstitial and alveolar spaces of the lung. CEP is typically suspected in a patient with progressive dyspnoea over one to four months and a chest radiograph showing bilateral peripheral or pleural-based opacities. Dominant extrapulmonary manifestations in CEP are rare. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320557PMC
February 2018
1 Read

Fatal Outcome of Ruptured Pulmonary Hydatid Cyst.

Tanaffos 2018 Feb;17(2):138-141

Tracheal Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences. Tehran, Iran.

Most authors believe that the optimal treatment for pulmonary hydatid cyst is surgery. Albendazole has been used as a prophylactic measure for reducing recurrence rate but there are some controversies about this strategy. Some researchers have described the increased risk of spontaneous rupture of cysts following albendazole treatment. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320564PMC
February 2018
2 Reads

Elastic Band Exercises for Patients with Intensive Care Unit-Acquired Weakness: A Case Report.

Tanaffos 2018 Feb;17(2):132-137

Department of Clinical, Integrated and Experimental Medicine (DIMES), Respiratory and Critical Care Unit, University Hospital St. Orsola-Malpighi, Bologna, Italy.

Intensive care unit-acquired weakness is characterised by severe impairment of muscle function that often arises after prolonged mechanical ventilation, difficult weaning, and severe sepsis. Elastic band exercises constitute an inexpensive and simple technique that is quite appealing for implementation in a "protected environment" such as the intensive care unit; however, elastic band application in the intensive care unit and in critical patients has not yet been described. A 72-year-old male was referred to the respiratory intensive care unit for hypoxemic respiratory failure due to acute respiratory distress syndrome. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320560PMC
February 2018
20 Reads

Successful Treatment of Refractory Massive Pulmonary Embolism with Repeated Administration of Systemic Thrombolysis.

Tanaffos 2018 Feb;17(2):127-131

Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.

Background: We report a case series of two patients in the intensive care unit with massive pulmonary embolism and obstructive shock who had resolution of shock after repeated administration of alteplase.

Case Summaries: Both patients were initially dosed 10 mg of alteplase followed by infusion of 90 mg over 2 hours, but remained in obstructive shock requiring significant inotropic and vasopressor support. Both patients were deemed poor candidates for embolectomy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320563PMC
February 2018
5 Reads

Drug Induced Sleep Endoscopy in Obstructive Sleep Apnea.

Tanaffos 2018 Feb;17(2):122-126

Department of Pulmonary and Critical Care Medicine, Lung Diseases Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.

Background: One of the main challenges of surgical treatment in Obstructive Sleep Apnea (OSA) is identifying the correct site of upper airway obstruction in an individual patient. Drug-Induced Sleep Endoscopy (DISE) in sedated patients with obstructive sleep apnea is the technique of choice for revealing anatomic and dynamic collapsible areas.

Materials And Methods: In a prospective cross-sectional study adult patients with OSA documented by polysomnography were evaluated by sleep endoscopy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320559PMC
February 2018
10 Reads

Role of Telemedicine in Pace of Consultation and Physicians' Satisfaction in Thoracic Surgery ICU.

Tanaffos 2018 Feb;17(2):117-121

Telemedicine Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Science, Tehran, Iran.

Background: Despite various applications of tele-ICU, there are still many questions about its costs and advantages in ICU. Some of its advantages are accelerating consultations and bringing physicians' satisfaction from tele-consultation outcomes. The aim of this study is to discuss these advantages. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320565PMC
February 2018
8 Reads

Is a Low Incidence Rate of Ventilation Associated Pneumonia Associated with Lower Mortality? a Descriptive Longitudinal Study in Iran.

Tanaffos 2018 Feb;17(2):110-116

Department of Anesthesiology and Critical Care, Anesthesiology Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Ventilator-Associated Pneumonia (VAP) is an important cause of morbidity and mortality in patients admitted to Intensive Care Unit (ICU). The current study conducted to estimate VAP incidence, attributable mortality and case fatality rate, cost, so related factors can affect the outcome in patients.

Materials And Methods: In this descriptive longitudinal study, demographic, clinical and para-clinical data were collected and attributable mortality and case fatality rate was estimated. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320555PMC
February 2018
5 Reads

The Effect of Adaptation Training on Controlling Maladaptation Behaviors in Adolescents with Asthma Based on Roy Adaptation Model.

Tanaffos 2018 Feb;17(2):103-109

Nursing and Midwifery Care Research Center, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Asthma is a common long term inflammatory disease during adolescent. Absence of school education and reduction of mental and social mindedness are among the most common problems found in adolescents with asthma. Therefore, the present study was aimed to examine the effect of Roy adaptation model on controlling maladaptation behaviors in adolescents with asthma. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320562PMC
February 2018
18 Reads

Comparison of the Efficacy of Budesonide Nebulizer Suspension and Budesonide Inhalation Suspension in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Tanaffos 2018 Feb;17(2):96-102

Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Inhaled corticosteroids have been successfully used to improve lung function. Budesonide nebulizer suspension and Budesonide inhalation suspension are two inhaled corticosteroids used in treating chronic obstructive pulmonary disorder (COPD). We compared the efficacy of Budesonide nebulizer suspension and Budesonide inhalation suspension in the treatment of patients with acute exacerbations of COPD, to prioritize the two treatments. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320566PMC
February 2018
2 Reads

Forced Expiratory Flow at 25-75% as a Marker for Airway Hyper Responsiveness in Adult Patients with Asthma-like Symptoms.

Tanaffos 2018 Feb;17(2):90-95

Air pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: The aim of the present study was threefold: to assess the association between baseline FEF and Airway Hyper-responsiveness (AHR), to specify whether a decrease in FEF may reflect severe hyper-responsiveness, and finally to confirm a FEF cut-off value.

Materials And Methods: In a cross sectional study in Imam Khomeini Hospital, Ahvaz, patients suffering from respiratory symptoms due the 2013 autumn rainfall with normal FEV1 and FEV1/FVC were evaluated by methacholine challenge test. Those with PD20<1000, 10002000 μg were classified as severe, moderate and mild AHR, respectively. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320556PMC
February 2018
8 Reads

Effect of Aerobic Exercises on Serum Levels of Apolipoprotein A1 and Apolipoprotein B, and Their Ratio in Patients with Chronic Obstructive Pulmonary Disease.

Tanaffos 2018 Feb;17(2):82-89

Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Cardiovascular disease is one of the most common disorders associated with chronic obstructive pulmonary disease (COPD). There are few studies on the effects of physical exercises, especially aerobic exercises, on serum levels of apolipoprotein A1 and apolipoprotein B in patients with COPD. The current study aimed at determining the effect of aerobic exercises on serum levels of apolipoprotein A1 and B and apo-A1/apo-B ratio. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320561PMC
February 2018
3 Reads

Reappraisal of Frequency of Common Cystic Fibrosis Transmembrane Conductance Regulator Gene Mutations in Iranian Cystic Fibrosis Patients.

Tanaffos 2018 Feb;17(2):73-81

Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Disease, (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Cystic Fibrosis (CF) is a life-threatening recessive genetic disorder resulting from mutations in the gene encoding the fibrosis transmembrane conductance regulator protein (CFTR). The CF clinical phenotype shows wide variation ranging from severe disease in early childhood in those homozygous for the p.Phe508del mutation to absence of the vas deferens in otherwise healthy men homozygous for the p. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320558PMC
February 2018
16 Reads

Immunologic Role of Extracellular Vesicles and Exosomes in the Pathogenesis of Cystic Fibrosis.

Tanaffos 2018 Feb;17(2):66-72

Pediatric Respiratory Disease Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran- Iran.

Cystic Fibrosis (CF) is the most common lethal autosomal recessive disease that affects many organs including, lung, pancreas and liver. Cystic fibrosis is a monogenic disease and occurs in the white Caucasians. Massive neutrophil granulocyte influx in the airways is one of the characteristics of CF. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320567PMC
February 2018
3 Reads

Community-Acquired Pneumonia with Negative Chest Radiography Findings: Clinical and Radiological Features.

Respiration 2019 Jan 9:1-10. Epub 2019 Jan 9.

Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.

Background: Data regarding community-acquired pneumonia (CAP) identified on chest computed tomography (CT) but not on chest radiography (CR) are limited.

Objectives: The present study aimed to investigate the clinical and radiological features of these patients.

Methods: We retrospectively compared the clinical characteristics, etiological agents, treatment outcomes, and CT findings between CAP patients with negative CR and positive CT findings (negative CR group) and those with positive CR as well as CT findings (control group). Read More

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http://dx.doi.org/10.1159/000495068DOI Listing
January 2019
7 Reads