5,566 results match your criteria Respiration[Journal]
Respiration 2018 Dec 13:1-12. Epub 2018 Dec 13.
Department of Pulmonary Disease, Erasmus Medical Centre, University Hospital Rotterdam, Rotterdam, The Netherlands.
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a dismal survival rate of only 3 years and no curative pharmacological therapy. The recent approval of 2 anti-fibrotic drugs (nintedanib and pirfenidone) that slow disease progression has provided some hope for patients. However, effectively managing anti-fibrotic treatment can be a challenge due to tolerability issues, the presence of pulmonary and extra-pulmonary comorbidities, and the need for concomitant medications in many patients. Read More
Respiration 2018 Dec 13:1-8. Epub 2018 Dec 13.
Division of Respirology, Department of Medicine, University of Ottawa, Ottawa, Ontario,
Background: Use of indwelling pleural catheters (IPCs) for the management of symptomatic pleural effusions in patients with mesothelioma has increased in popularity. An important concern with this approach is the potential for the development of catheter tract metastasis (CTM).
Objectives: To determine the incidence of IPC-related CTM in patients with malignant pleural mesothelioma (MPM). Read More
Respiration 2018 Dec 13:1-8. Epub 2018 Dec 13.
Background: Most of the patients on noninvasive positive pressure ventilation require aerosol inhalation therapy to moisturize the airways or deliver drugs in acute settings. However, the effect of jet nebulization on noninvasive positive pressure ventilation (NPPV) has not been determined.
Objectives: This study was designed to investigate the impact of jet nebulization on NPPV applied in ventilators. Read More
Respiration 2018 Dec 12:1-2. Epub 2018 Dec 12.
Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Respiration 2018 Dec 6:1-10. Epub 2018 Dec 6.
Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Background: Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a rare interstitial pneumonia that is characterized by stiffness in both the upper lobes and pleura, which is evident on high resolution computed tomography (HRCT) of the chest. However, prognostic factors for IPPFE have not been identified yet.
Objective: We aimed to investigate the clinical prognostic factors affecting survival in patients with IPPFE. Read More
Respiration 2018 Nov 28:1-8. Epub 2018 Nov 28.
Department of Pulmonology, University Hospital Zurich, Zurich,
Background: In Ehlers-Danlos syndrome (EDS), a group of monogenic disorders affecting connective tissues, obstructive sleep apnoea (OSA) is highly prevalent in adults. The prevalence of OSA in children with EDS is unknown.
Objectives: This prospective cross-sectional study aimed at determining the prevalence of OSA in paediatric EDS patients. Read More
Respiration 2018 Nov 27:1-8. Epub 2018 Nov 27.
Servicio Cántabro de Salud, Santander, Spain.
Background: In chronic obstructive pulmonary disease (COPD), low muscle mass has been associated with several clinical outcomes such as low exercise capacity, hospital admission, and mortality. The Sarcopenia Index (SI) is a novel way to estimate muscle mass based on the ratio of serum creatinine (produced exclusively by muscle)/cystatin C (produced by all nucleated body cells).
Objectives: This study aims to assess the SI in stable COPD outpatients, as compared with a healthy control group, to quantify its relationship with several important clinical features in COPD, and to study its potential usefulness to predict COPD exacerbations and hospital admissions. Read More
Respiration 2018 Nov 22:1-9. Epub 2018 Nov 22.
Department of Respiratory Medicine/Thoracic Oncology, Onze-Lieve-Vrouw Ziekenhuis Aalst, Aalst,
Background: In patients with locally advanced lung cancer treated with concurrent chemoradiation, outcome measurements have been mostly limited to survival.
Objectives: We aimed to measure outcomes that matter to these patients beyond survival in a general clinical practice.
Methods: In a prospective single-centre study, consecutive patients with locally advanced non-small cell lung cancer reported their own outcomes using the EORTC Quality of Life Questionnaire Core 30 at baseline, during therapy, at therapy stop and till 1 year after therapy end every 3 months. Read More
Respiration 2018 Nov 19:1-3. Epub 2018 Nov 19.
Respiration 2018 Nov 14. Epub 2018 Nov 14.
Respiration 2018 Nov 14:1-5. Epub 2018 Nov 14.
Department of Respiratory Medicine, Amsterdam University Medical Centers, Amsterdam, The
Background: Transbronchial cryobiopsy (TBCB) of the lung parenchyma is a minimally invasive alternative for surgical lung biopsy in interstitial lung disease (ILD) patients. Drawbacks are the nondiagnostic rate and complication risk of pneumothorax and bleeding. Fluoroscopy is the current guidance tool for TBCB, which is limited by 2D imaging and a radiation dose for the patient. Read More
Respiration 2018 Nov 13:1-12. Epub 2018 Nov 13.
The purpose of this review is to provide an overview on how interactions between control of breathing, respiratory load, and muscle function may lead to respiratory failure. The mechanisms involved vary according to the underlying pathology, but respiratory failure is most often the result of an imbalance between the muscular pump and the mechanical load placed upon it. Changes in respiratory drive and response to CO2 seem to be important contributors to the pathophysiology of respiratory failure. Read More
Respiration 2019 12;97(1):15-23. Epub 2018 Nov 12.
Ben-Gurion University, Beer-Sheva,
Background: Several studies in animal models and human with obstructive sleep apnea syndrome (OSAS) demonstrated an increase in cancer aggressiveness and mortality. However, there is a need for further clinical evidence supporting a correlation between OSAS and cancer incidence.
Objectives: To reveal whether OSAS presence and severity is correlated with cancer incidence in a large homogenous patients' cohort. Read More
Respiration 2019 8;97(1):60-69. Epub 2018 Nov 8.
Pediatric Respiratory Medicine Unit, Department of General Pediatrics, University Hospital Münster, Münster,
Background: Cough is a key symptom in patients with cystic fibrosis (CF) and primary ciliary dyskinesia (PCD).
Objective: The study objectives were to test whether cough is related to parameters reflecting their disease severity and whether CF and PCD differ in cough frequency.
Methods: In this prospective observational study, we used a microphone-based monitoring system (LEOSound® Monitor) to count the coughs in healthy subjects (HS) and in stable patients with CF and PCD (25 subjects per group) on 2 consecutive nights. Read More
Respiration 2018 Nov 8:1-9. Epub 2018 Nov 8.
Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Background: Recent advances in bronchoscopy utilizing endobronchial ultrasound (EBUS) as well as lung cancer therapy may have driven physicians to perform diagnostic bronchoscopy (DB) for high-risk patients.
Objectives: The aim of this study was to clarify the relationship between hospital volume (HV) and outcomes of DB.
Methods: We collected data on inpatients with lung cancer who underwent DB from July 2010 to March 31, 2014. Read More
Respiration 2018 Nov 8:1-5. Epub 2018 Nov 8.
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing,
Primary mucosa-associated lymphoid tissue (MALT) lymphoma of the trachea is very rare and is easily misdiagnosed as a bronchogenic carcinoma or benign tracheal tumor. Here, we report a clinical case where a new clinical approach involving a water-jet hybrid knife was employed in the diagnosis and treatment of primary tracheal MALT lymphoma. Read More
Respiration 2018 Nov 7:1-8. Epub 2018 Nov 7.
Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark.
Background: Clinical lung ultrasound (LUS) is a fast bedside diagnostic tool which can assist clinicians in decisions regarding the treatment and monitoring of patients with respiratory symptoms. LUS training and education differ widely, and is often done in a clinical setting, with potential risks for patients if decisions are made based on the wrong interpretations. No clear guidelines or recommendations for objective and standardized assessment of LUS skills exist, and those that do are often based on a fixed time-frame or an arbitrary number of examinations performed; this does not ensure adequate competencies. Read More
Respiration 2018 Nov 7:1-3. Epub 2018 Nov 7.
Respiration 2018 Nov 2:1-8. Epub 2018 Nov 2.
Copenhagen Academy for Medical Education and Simulation (CAMES), Copenhagen, Denmark.
Background: Several studies have shown the beneficial effects of mastery learning of a simulation-based course, but not all trainees complete it.
Objectives: The purpose of this study was to find deciding factors for the completion of a simulation-based mastery learning course with distributive practice in flexible bronchoscopy.
Methods: Seventy-seven trainees who signed up for the course were invited to a survey for deciding factors of completing the course. Read More
Respiration 2018 Nov 2:1-10. Epub 2018 Nov 2.
Cologne Merheim Hospital, Witten/Herdecke University, Cologne, Germany.
Background: The fixed-dose combination of budesonide/formoterol (B/F) has been available in the Spiromax® dry powder inhaler since 2014.
Objectives: To assess patient satisfaction, inhaler use errors, and disease control in patients with asthma or chronic obstructive pulmonary disease (COPD) treated with B/F Spiromax.
Methods: This non-interventional, prospective, 12-week study enrolled consecutive asthma or COPD patients who had recently begun treatment with B/F Spiromax or were switched from another inhaled corticosteroid/long-acting β2-agonist combination to B/F Spiromax in routine clinical practice. Read More
Respiration 2019 31;97(1):3-11. Epub 2018 Oct 31.
Istituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Institute of Montescano (PV), Montescano, Italy.
Background: Chronic ventilatory failure (CVF) may be associated with reduced exercise capacity. Long-term non-invasive ventilation (NIV) may reduce patients' symptoms, improve health-related quality of life and reduce mortality and hospitalisations. There is an increasing use of NIV during exercise training with the purpose to train patients at intensity levels higher than allowed by their pathophysiological conditions. Read More
Respiration 2018 Oct 26:1-4. Epub 2018 Oct 26.
Department of Pulmonary and Critical Care Medicine, the Second Affiliated Hospital of Fujian Medical University, the Second Clinical Medical College of Fujian Medical University, Center of Respiratory Medicine of Fujian Province, Quanzhou, China.
Closure of bronchopleural fistula remains a difficult challenge for clinicians. Although several therapeutic approaches have been proposed, the clinical results are commonly unsatisfactory. Previous reports have indicated that autologous mesenchymal stem cells (MSCs) are useful for aiding treatment of bronchopleural fistula. Read More
Respiration 2018 Oct 25:1-3. Epub 2018 Oct 25.
COPD Center, Institute of Medicine, Sahlgrenska University Hospital, Gothenburg University, Gothenburg, Sweden.
Respiration 2019 19;97(1):84-91. Epub 2018 Oct 19.
Graduate School of Medicine, Teikyo University, Tokyo,
Background: Filamentous basidiomycetes (f-BMs) are involved in some unexplained chronic cough (UCC) cases that can be improved by the administration of antifungal agents. The disease concept was termed fungus-associated chronic cough (FACC). The current diagnostic criteria warrant environmental fungi isolation from respiratory specimens, which is hardly conceivable for such fungi. Read More
Respiration 2018 Oct 17:1-10. Epub 2018 Oct 17.
Kliniken für Pneumologie und Infektiologie, Thoraxzentrum Ruhrgebiet, Herne, Germany.
Background: The impact of respiratory tract pathogens and infection on outcomes in patients with prolonged weaning is largely unknown.
Objective: We studied predictors of weaning outcomes (death and failure to achieve spontaneous ventilation) in a population treated during a 3.5-year period in a specialized and certified weaning centre. Read More
Respiration 2018 Oct 17:1-10. Epub 2018 Oct 17.
Background: Although phase 3 trials showed significant efficacy and acceptable safety profiles for pirfenidone in mild-to-moderate idiopathic pulmonary fibrosis (IPF), data on advanced IPF are limited.
Objectives: The study aimed to evaluate the efficacy and safety of pirfenidone in advanced IPF patients.
Methods: The clinical data of 138 IPF patients (advanced group: 27%) treated with pirfenidone were retrospectively reviewed and compared between advanced and non-advanced groups. Read More
Respiration 2018 11;96(6):571-587. Epub 2018 Oct 11.
Center for Interstitial and Rare Lung Diseases, Pneumology and Respiratory Critical Care Medicine, Thoraxklinik, University of Heidelberg and Translational Lung Research Center Heidelberg, member of the German Center for Lung Research, Heidelberg, Germany.
The mechanisms of idiopathic pulmonary fibrosis (IPF), a rare, devastating disease with a median survival of 3-5 years, are not fully understood. Gastroesophageal reflux disease (GERD) is a frequent comorbidity encountered in IPF. Hypothetically, GERD-associated microaspiration may lead to persistent inflammation impairing lung infrastructure, thereby possibly accelerating the progression of IPF. Read More
Respiration 2018 9;96(5):403-405. Epub 2018 Oct 9.
Department of Respiratory Medicine, National Reference Center for Rare Pulmonary Diseases, Hospices Civils de Lyon, Lyon, France.
Respiration 2018 9;96(6):590. Epub 2018 Oct 9.
Geneva Medical University, Geneva University Hospitals, Geneva,
Respiration 2018 Oct 5:1-8. Epub 2018 Oct 5.
Istituti Clinici Scientifici Maugeri, IRCCS Montescano, Montescano, Italy.
Background: After undergoing a procedure of pulmonary endarterectomy (PEA), patients with chronic thromboembolic pulmonary hypertension (CTEPH) may still experience reduced exercise capacity. Data on effects of exercise training in these patients are scant.
Objectives: To evaluate the effectiveness of exercise training after PEA for CTEPH and if the presence of "residual pulmonary hypertension" may affect the outcome. Read More
Respiration 2018 Oct 5:1-11. Epub 2018 Oct 5.
Children's Hospital, Klinikum Leverkusen, Leverkusen, Germany.
Background: Congenital cardiovascular malformations (CCVM) may cause infrequently airway pathologies (AP) in children and are of prognostic and therapeutic relevance. While computed tomography (CT) is considered first-line imaging modality in many centres, we started using magnetic resonance imaging (MRI) more and more in the last years to detect CCVM and AP to avoid radiation in this patient group.
Objective: The aim of this retrospective study was to determine and to compare the diagnostic accuracy of CT and MRI when used to detect CCVM and/or AP. Read More
Respiration 2019 4;97(1):78-83. Epub 2018 Oct 4.
Background: Radial-probe endobronchial ultrasound (RP-EBUS) is predominantly used clinically for the localisation of peripheral pulmonary lesions prior to biopsy. However, the RP-EBUS image itself contains information that can characterise the aetiology of lesions.
Objectives: The aim of this study was to show the utility of RP-EBUS image analysis using unconstrained regions of interest (ROIs) that utilise more image information and eliminate ROI selection bias. Read More
Respiration 2018 4;96(6):507-513. Epub 2018 Oct 4.
Center for Respiratory Diseases, National Hospital Organization Tokyo National Hospital, Tokyo, Japan.
Background: While nontuberculous mycobacterial (NTM) pleuritis rarely complicates pulmonary NTM infection, high mortality has been reported in case reports and small studies.
Objectives: The purpose of this study was to clarify the clinical features and treatment outcomes of pulmonary NTM infection cases accompanied by NTM pleuritis.
Methods: Medical records of 1,044 patients with pulmonary NTM disease were retrospectively reviewed to select patients complicated by NTM-proven pleuritis. Read More
Respiration 2018 4;96(6):588-589. Epub 2018 Oct 4.
Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Respiration 2018 3;96(6):495-496. Epub 2018 Oct 3.
Respiration 2019 28;97(1):1-2. Epub 2018 Sep 28.
Pulmonary Division and Sleep Disorders Centre, University Hospital Zurich, Zurich, Switzerland.
Respiration 2018 Sep 28:1-10. Epub 2018 Sep 28.
Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
Background: Changes in pulmonary hemodynamics and cardiac function in patients with chronic obstructive pulmonary disease (COPD) traveling to altitude have not been assessed despite an increasing prevalence of the disease.
Objectives: We hypothesized that pulmonary artery pressure (PAP) significantly increases and cardiac function deteriorates during exposure to hypobaric hypoxia as encountered by traveling to moderate altitude or air flight.
Methods: A total of 37 patients (17 female; median age [quartiles] 66 years [60; 69] with COPD GOLD grade 2-3 [FEV1 57% predicted (49; 71)]) living < 800 m underwent echocardiography in Zurich (490 m) and after 1 night at Davos Jakobshorn (2,590 m) in a randomized order of allocation. Read More
Respiration 2018 Sep 27:1-6. Epub 2018 Sep 27.
Pulmonary Department Clínica Universidad de Navarra, CIBERes, Madrid, Spain.
Background: Obstructive sleep apnea (OSA) has been linked to tumorigenesis and tumor progression.
Objectives: The Sleep Apnea in Lung Cancer (SAIL) study (NCT02764866) was designed to determine the prevalence of OSA in patients with lung cancer.
Methods: Cross-sectional study including consecutive patients with newly diagnosed lung cancer. Read More
Respiration 2018 26;96(5):434-445. Epub 2018 Sep 26.
Department of Pulmonary Medicine, MD Anderson Cancer Center, Houston, Texas, USA.
Background: Predictions that overestimate post-lobectomy lung function are more likely than underestimates to lead to lobectomy. Studies of post-lobectomy lung function have included only surgical patients, so overestimates are overrepresented. This selection bias has led to incorrect estimates of prediction bias, which has led to inaccurate threshold values for determining lobectomy eligibility. Read More
Respiration 2018 Sep 25:1-7. Epub 2018 Sep 25.
Department of Internal Medicine, Zealand University Hospital, Roskilde, Denmark.
Background: Diagnosing centrally located lung tumors without endobronchial abnormalities and not located near the major airways is a diagnostic challenge. Tumors near or adjacent to the esophagus can be aspirated and detected with esophageal ultrasound (EUS) using gastrointestinal endoscopes.
Objective: To assess the feasibility and diagnostic yield of endoscopic ultrasound with bronchoscope-guided fine needle aspiration (EUS-B-FNA) in paraesophageally located lung tumors and its added value to bronchoscopy and endobronchial ultrasound (EBUS). Read More
Respiration 2018 18;96(4):370-381. Epub 2018 Sep 18.
Department of Biomedical Sciences, Humanitas University, Milano, Italy.
Background: While fixed dose combinations (FDCs) of long-acting beta 2-agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) are increasingly tested on their efficacy in improving lung function, their effectiveness on Patient Reported Outcomes (PROs) such as Health Related Quality of Life (HRQoL) and Health Status (HS) deserve more attention.
Objectives: To review current available evidence about the treatment effect of fixed LABA/LAMA FDCs on HRQoL.
Methods: A systematic literature search for randomized controlled trials (RCTs) about the impact of LABA/LAMA FDCs versus placebo, LABA or LAMA or LABA/ICS on HRQoL in Chronic obstructive pulmonary disease (COPD) patients has been performed. Read More
Respiration 2019 18;97(1):12-14. Epub 2018 Sep 18.
Respiration 2019 18;97(1):42-51. Epub 2018 Sep 18.
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou,
Background: Hydrogen-oxygen mixture (H2-O2) may reduce airway resistance in patients with acute severe tracheal stenosis, yet data supporting the clinical use of H2-O2 are insufficient.
Objectives: To evaluate the efficacy and safety of breathing H2-O2 in acute severe tracheal stenosis.
Methods: Thirty-five consecutive patients with severe acute tracheal stenosis were recruited in this prospective self-control study. Read More
Respiration 2018 Sep 18:1-8. Epub 2018 Sep 18.
Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Heidelberg, Germany.
Background: Endoscopic valve therapy leads to an improvement of lung function, exercise tolerance, and quality of life in a selected cohort of patients with advanced emphysema. So far, only few data exist on the long-term outcome.
Objectives: This analysis evaluated the impact of valve therapy on the survival of emphysema patients. Read More
Respiration 2018 18;96(6):525-534. Epub 2018 Sep 18.
Department of Respiratory Medicine, Hospital Universitari de Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), Universitat de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Barcelona,
Rationale: Virtual bronchoscopic navigation (VBN) guidance to peripheral pulmonary lesions is often limited by insufficient segmentation of the peripheral airways.
Objectives: To test the effect of applying positive airway pressure (PAP) during CT acquisition to improve segmentation, particularly at end-expiration.
Methods: CT acquisitions in inspiration and expiration with 4 PAP protocols were recorded prospectively and compared to baseline inspiratory acquisitions in 20 patients. Read More
Respiration 2019 18;97(1):70-77. Epub 2018 Sep 18.
Background: Indwelling pleural catheters (IPC) offer an alternative to talc pleurodesis in recurrent effusion, especially in patients wishing to avoid hospitalization. Two randomized trials have demonstrated reduced time in hospital using IPCs versus talc pleurodesis in malignant pleural effusion (MPE). However, the impact of IPCs on hospital services and patients has not been well studied. Read More
Respiration 2018 13;96(5):488-494. Epub 2018 Sep 13.
Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Managing complex benign airway disease is a major challenge in interventional pulmonology. Airway stent placement can result in complications due to a variety of factors, including poor fit of the stent in the airway. We report the 1-year outcome of 2 patients with airway disease caused by granulomatosis with polyangiitis (Wegener's) affecting the left main bronchus and secondary carina. Read More
Respiration 2018 13;96(6):497-499. Epub 2018 Sep 13.
Respiration 2019 13;97(1):92. Epub 2018 Sep 13.
Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Heidelberg, Germany.
Respiration 2018 Sep 11:1-7. Epub 2018 Sep 11.
State Key Laboratory of Respiratory Disease, Guangzhou Institute for Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Background: Patients with pulmonary tuberculosis (PTB) have a high risk of concomitant tracheobronchial tuberculosis (TBTB), which commonly causes severe complications such as tracheobronchial stenosis. The prevalence and predictors of TBTB in China remain unclear due to the lack of prospective and large-scale studies.
Objectives: To investigate the incidence of TBTB in PTB patients in southern China, and elucidate the predictors of TBTB and related tracheobronchial stenosis. Read More