3,125 results match your criteria Reproductive Toxicology[Journal]


Panax ginseng methabolit (GIM-1) prevents oxidative stress and apoptosis in human Sertoli cells exposed to Monobutyl-phthalate (MBP).

Reprod Toxicol 2019 Apr 6;86:68-75. Epub 2019 Apr 6.

São Paulo State University (UNESP), Institute of Biosciences, Department of Morphology, Botucatu, SP, 18618-689, Brazil. Electronic address:

This study evaluated oxidative stress markers in Human Sertoli cells cultivated on Geltrex® and exposed to Monobutyl Phthalate (MBP), and the potential cytoprotective role of GIM-1 on the antioxidant response. Exposure was performed at 30 min, 1, 12 and 48 h into 4 groups: control, MBP (10μM), GIM-1 (0,05μM) and MBP + GIM-1. Morphology was evaluated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08906238183061
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http://dx.doi.org/10.1016/j.reprotox.2019.02.008DOI Listing
April 2019
3 Reads

Statistical sensitivity analysis for the estimation of fetal alcohol spectrum disorders prevalence.

Reprod Toxicol 2019 Apr 5;86:62-67. Epub 2019 Apr 5.

Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, United States; Department of Pediatrics, University of California, San Diego, La Jolla, CA, United States.

Fetal alcohol spectrum disorders (FASD) are thought to be the leading cause of developmental disabilities worldwide. Accurate estimates of the prevalence of FASD have been lacking. An improved estimate of FASD prevalence in the U. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.04.002DOI Listing

Impact of prenatal arsenate exposure on gene expression in a pure population of migratory cranial neural crest cells.

Reprod Toxicol 2019 Apr 3;86:76-85. Epub 2019 Apr 3.

Department of Oral Immunology and Infectious Diseases, Division of Craniofacial Development and Anomalies, ULSD, University of Louisville, Louisville, KY 40202, United States.

Prenatal exposure to arsenic, a naturally occurring toxic element, causes neural tube defects (NTDs) and, in animal models, orofacial anomalies. Since aberrant development or migration of cranial neural crest cells (CNCCs) can also cause similar anomalies within developing embryos, we examined the effects of in utero exposure to sodium arsenate on gene expression patterns in pure populations of CNCCs, isolated by fluorescence activated cell sorting (FACS), from Cre/LoxP reporter mice. Changes in gene expression were analyzed using Affymetrix GeneChip microarrays and expression of selected genes was verified by TaqMan quantitative real-time PCR. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.04.001DOI Listing

Retinoic acid signaling determines the fate of the uterus from the mouse Müllerian duct.

Reprod Toxicol 2019 Mar 30;86:56-61. Epub 2019 Mar 30.

Graduate School of Nanobioscience, Yokohama City University, Yokohama 236-0027, Japan. Electronic address:

In female mice, the Müllerian duct develops into the oviduct, uterus and vagina. The fate of epithelia is determined by factors secreted from the mesenchyme. Retinoic acid (RA) and its receptors are present in the mesenchyme of cranial Müllerian duct. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.03.006DOI Listing
March 2019
5 Reads

The ossification status of Wistar rat fetuses at the end of gestation.

Reprod Toxicol 2019 Mar 23;86:45-49. Epub 2019 Mar 23.

Trier University, Department of Biogeography, Universitätsring 15, D-54286 Trier, Germany.

We present a comprehensive description of spontaneous skeletal development of Wistar rat fetuses close to parturition. Fetuses were collected on the day of expected parturition and one and two days before (Gestation Days 21-23) and skeletal development state was examined. Data is presented on an individual fetal basis to allow insights in developmental patterns. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.03.005DOI Listing

The association between sperm DNA fragmentation and reproductive outcomes following intrauterine insemination, a meta analysis.

Reprod Toxicol 2019 Mar 21;86:50-55. Epub 2019 Mar 21.

Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi province, PR China. Electronic address:

Sperm DNA fragmentation has been suggested as a predictor of pregnancy of intrauterine insemination (IUI), but the controversy still exists. Then a meta-analysis was performed to evaluate the association between sperm DNA fragmentation and reproductive outcomes. A total of 10 articles retrieved from the databases of PUBMED, MEDLINE, EMBASE and WANFANG were included in the meta-analysis. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.03.004DOI Listing
March 2019
6 Reads

Differential effects of ambient PAH mixtures on cellular and steroidogenic properties of placental JEG-3 and BeWo cells.

Reprod Toxicol 2019 Mar 20;86:14-22. Epub 2019 Mar 20.

Department of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Kraków, Kraków, Poland. Electronic address:

We determined the action of a mixture of 16 priority PAHs present in high concentrations in maternal blood (Mix I) and the same but in low concentrations detected in placental tissue (Mix II) on AhR, ERα, NFκB, CYP1A1, CYP1B1, and COMT protein expression and cell proliferation of JEG-3 and BeWo cell lines. Both mixtures induced AhR expression in JEG-3 and BeWo; however, in JEG-3 cells expression of ERα, CYP1A1, CYP1B1, and COMT was upregulated, while in BeWo cells downregulated. The opposite effect of mixtures on NFκB protein expression (inhibitory in JEG-3, stimulatory in BeWo) was noted. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.03.003DOI Listing

A multi-institutional study benchmarking the zebrafish developmental assay for prediction of embryotoxic plasma concentrations from rat embryo-fetal development studies.

Reprod Toxicol 2019 Mar 13;86:33-44. Epub 2019 Mar 13.

Medicine for Malaria Venture, Geneva, Switzerland.

Predicting embryotoxicity of pharmaceutical compounds or industrial chemicals is crucial for public safety. Conventional studies which monitor embryo-fetal development in rats and rabbits are costly and time consuming. Alternative assays which are simpler and less costly are being pursued. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.004DOI Listing
March 2019
1 Read

Developmental programming: Changes in mediators of insulin sensitivity in prenatal bisphenol A-treated female sheep.

Reprod Toxicol 2019 Apr 7;85:110-122. Epub 2019 Mar 7.

Departments of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA; Departments of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Developmental exposure to endocrine disruptor bisphenol A (BPA) is associated with metabolic defects during adulthood. In sheep, prenatal BPA treatment causes insulin resistance (IR) and adipocyte hypertrophy in the female offspring. To determine if changes in insulin sensitivity mediators (increase in inflammation, oxidative stress, and lipotoxicity and/or decrease in adiponectin) and the intracrine steroidal milieu contributes to these metabolic perturbations, metabolic tissues collected from 21-month-old female offspring born to mothers treated with 0, 0. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443435PMC

Use of ondansetron during pregnancy and the risk of major congenital malformations: A systematic review and meta-analysis.

Reprod Toxicol 2019 Mar 5;86:1-13. Epub 2019 Mar 5.

Mothersafe, The Royal Hospital for Women, Sydney, New South Wales, Australia; School of Women's and Children's Health University of New South Wales, Australia.

Aims: To investigate whether ondansetron use during pregnancy is associated with increased rates of major or subgroups of malformations.

Methods: PubMed/MEDLINE, Cochrane and Reprotox databases were searched. Observational studies comprising an exposed and control group (healthy and/or disease-matched) were included. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.03.001DOI Listing
March 2019
2 Reads

Hospital centered surveillance of births in Gaza, Palestine, 2011-2017 and heavy metal contamination of the mothers reveals long-term impact of wars.

Reprod Toxicol 2019 Mar 5;86:23-32. Epub 2019 Mar 5.

I.T. Independent Professional, Gaza, Palestine. Electronic address:

Prevalence of preterm, low birth weight and birth defects increased significantly since 2011 in Gaza, Palestine. No change in known co-factors of reproductive health justified this rise. Two military attacks in 2012 and 2014 introduced novel risk factors for outcomes at birth: contamination by teratogenic and carcinogenic heavy metals weapon-remnants, ongoing impoverishment, and impaired rehabilitation of waste management. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.003DOI Listing
March 2019
3.227 Impact Factor

Body size at birth, early-life growth and the timing of the menopausal transition and natural menopause.

Reprod Toxicol 2019 Mar 1. Epub 2019 Mar 1.

Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA; The Imprints Center for Genetic and Environmental Lifecourse Studies, Columbia University Mailman School of Public Health, New York, NY, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA. Electronic address:

Background: Whether birth weight and early-life growth are associated with age at menopause has not been resolved.

Methods: We conducted a prospective study in two U.S. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.013DOI Listing
March 2019
1 Read

Can oxybenzone cause Hirschsprung's disease?

Reprod Toxicol 2019 Mar 1. Epub 2019 Mar 1.

Haereticus Environmental Laboratory, Clifford, VA, USA.

Oxybenzone is a ultraviolet (UV) absorber used in 70% of sunscreen products, is a recognized endocrine disrupting chemical (EDC) and is small enough to pass through skin and placenta barriers. Numerous studies have identified this chemical in the urine/blood of pregnant women as well as in fetal and umbilical cord blood. A recent study demonstrated that women with medium to high levels of oxybenzone in their urine was associated with giving birth to neonates with Hirschsprung's Disease (HSCR). Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.014DOI Listing

HT-2 toxin exposure induces mitochondria dysfunction and DNA damage during mouse early embryo development.

Reprod Toxicol 2019 Apr 1;85:104-109. Epub 2019 Mar 1.

College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China. Electronic address:

HT-2 toxin is one of the type A trichothecene mycotoxins existed in contaminated feed and has exerted various toxic effects on human and livestock, as it induces lesions in multiple tissues including reproductive system. However, till now it is still unclear about the toxicity of HT-2 on mammalian embryos. In this study, we showed that HT-2 treatment disrupted mouse early embryo development, and we also found the occurrence of oxidative stress, showing with the increased ROS level. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.011DOI Listing
April 2019
1 Read

Exposure to mercury and human reproductive health: A systematic review.

Reprod Toxicol 2019 Apr 1;85:93-103. Epub 2019 Mar 1.

Department of Medical Sciences, Institute of Biomedicine - iBiMED, University of Aveiro, 3810-193, Aveiro, Portugal. Electronic address:

Background: Evidences from human and animal studies suggest that reproductive function may be affected by mercury. The aim of this review was to explore the mercury influence on human fertility.

Methods: A systematic search was made in PubMED for papers published between 1975-2017, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.012DOI Listing
April 2019
2 Reads

DDT exposure during pregnancy and DNA methylation alterations in female offspring in the Child Health and Development Study.

Reprod Toxicol 2019 Feb 26. Epub 2019 Feb 26.

Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, United States; Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY, United States; Imprints Center, Columbia University Medical Center, New York, NY, United States; Department of Epidemiology, Mailman School of Public Health of Columbia University, New York, NY, United States.

Studies measuring dichlorodiphenyltrichloroethane (DDT) exposure during key windows of susceptibility including the intrauterine period suggest that DDT exposure is associated with breast cancer risk. We hypothesized that prenatal DDT exposure is associated with DNA methylation. Using prospective data from 316 daughters in the Child Health and Development Study, we examined the association between prenatal exposure to DDTs and DNA methylation in blood collected in midlife (mean age: 49 years). Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.010DOI Listing
February 2019
2 Reads

Bisphenol-S promotes endocrine-disrupting effects similar to those promoted by bisphenol-A in the prostate of adult gerbils.

Reprod Toxicol 2019 Apr 26;85:83-92. Epub 2019 Feb 26.

Department of Histology, Embryology and Cell Biology, Laboratory of Microscopy Applied to Reproduction, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Goiás, 74001970, Brazil. Electronic address:

This study evaluated the effects of BPS (40 μg/kg/day, during 28 consecutive days) on the male ventral prostate and female prostate of adult gerbils. For comparative purposes, gerbils were also exposed to BPA under the same experimental conditions. The prostates were submitted to biometric, morphometric, histopathological, immunohistochemical and ultrastructural analyses. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.009DOI Listing

Safety assessment of cefuroxime on male reproductive system: Subacute toxicity and potential reversibility after a complete cycle of spermatogenesis and epididymal maturation in Wistar rats.

Reprod Toxicol 2019 Apr 22;85:75-82. Epub 2019 Feb 22.

Research Unit of Pharmacology and Toxicology of Xenobiotics (UR12 ES13), Faculty of Medicine, University of Sfax, Tunisia. Electronic address:

The effects of cefuroxime on reproductive system were investigated in male rats. Doses of 0, 30, 60 or 120 mg/kg of cefuroxime were intraperitoneally injected daily, for 7 days. Half of the rats were euthanized 24 h after the last dose and other half were induced to death 70 days after the last treatment. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.007DOI Listing
April 2019
1 Read
3.227 Impact Factor

Dietary exposure to mycotoxin zearalenone (ZEA) during post-implantation adversely affects placental development in mice.

Reprod Toxicol 2019 Apr 14;85:42-50. Epub 2019 Feb 14.

Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA; Interdisciplinary Toxicology Program, University of Georgia, Athens, GA, USA. Electronic address:

Zearalenone (ZEA) is a common food contaminant (ppb-ppm) derived from Fusarium fungi. With its estrogenicity and potential chronic exposure, ZEA poses a risk to pregnancy. Our previous studies implied post-implantational lethality by ZEA. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443452PMC

Prenatal exposure to pyrrolizidine alkaloids induced hepatotoxicity and pulmonary injury in fetal rats.

Reprod Toxicol 2019 Apr 13;85:34-41. Epub 2019 Feb 13.

Department of pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Diseases, Wuhan 430071, China. Electronic address:

Hepatic and pulmonary toxicity in fetal rats induced by pyrrolizidine alkaloids (PAs) was investigated. Retrorsine (RTS) or monocrotaline (MCT) was intragastrically administered during pregnancy. The reduction of body and tail lengths was consistent with body weight loss in PA-exposed fetuses, and pathological lesions in liver and lung were observed only in fetuses. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.006DOI Listing
April 2019
3 Reads

Trehalose restores functional autophagy suppressed by high glucose.

Reprod Toxicol 2019 Apr 12;85:51-58. Epub 2019 Feb 12.

Department of Obstetrics, Gynecology & Reproductive Sciences, Baltimore, MD, USA; Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA. Electronic address:

Autophagy is required for neurulation, and autophagy activators with minimal toxicity, such as the natural compound trehalose, a nonreducing disaccharide, possess high therapeutic value. To determine whether trehalose directly induces autophagy, FITC-labeled trehalose was used for tracing its presence in autophagosome complexes. Trehalose was as potent as rapamycin and starvation in inducing de novo autophagosome formation and increasing autophagosome flux in GFP-LC3 reporter cells and C17. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.005DOI Listing
April 2019
3 Reads
3.227 Impact Factor

Pregnancy outcomes following quinolone and fluoroquinolone exposure during pregnancy: A systematic review and meta-analysis.

Reprod Toxicol 2019 Apr 7;85:65-74. Epub 2019 Feb 7.

Izmir Katip Celebi University, Faculty of Medicine, Department of Pharmacology Izmir, Turkey; Terafar, Izmir Katip Celebi University Teratology Information, Training and Research Center, Izmir, Turkey.

Objective: To investigate whether maternal exposure to quinolones, fluoroquinolones and specifically ciprofloxacin is associated with major malformations and other adverse pregnancy outcomes.

Methods: MEDLINE/PubMed, Embase and Reprotox® databases were searched. Observational studies with an exposed and control group were included. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.002DOI Listing
April 2019
7 Reads

Mitochondrial-related gene associated to obesity can be modulated by in utero hyperglycemic environment.

Reprod Toxicol 2019 Apr 6;85:59-64. Epub 2019 Feb 6.

UNESP, São Paulo State University, Botucatu Medical School, Department of Pathology, Botucatu, São Paulo, Brazil.

We investigated whether mitochondrial-related genes and proteins are modulated by hyperglycemia promoted by gestational diabetes (GDM), thereby increasing neonate obesity predisposition. 19 healthy pregnant women, 16 pregnant women with GDM and their respective neonates were enrolled. Additionally, 19 obese and 19 eutrophic adults were recruited as a reference population. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.001DOI Listing
April 2019
1 Read

Adverse outcome pathway of developmental neurotoxicity resulting from prenatal exposures to cannabis contaminated with organophosphate pesticide residues.

Reprod Toxicol 2019 Apr 19;85:12-18. Epub 2019 Jan 19.

Department of Pesticide Regulation, California Environmental Protection Agency, Sacramento, 1001 I Street, Sacramento, CA 95812, United States.

There is growing concern that increased use of medical and recreational cannabis may result in increased exposure to contaminants on the cannabis, such as pesticides. Several states are moving towards implementing robust regulation of the sales, cultivation, and manufacture of cannabis products. However, there are challenges with creating health-protective regulations in an industry that, to date, has been largely unregulated. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.01.004DOI Listing
April 2019
7 Reads

Screening for prenatal alcohol exposure and corresponding short-term neonatal outcomes.

Reprod Toxicol 2019 Apr 18;85:6-11. Epub 2019 Jan 18.

Department of Obstetrics and Gynecology, West Virginia University-Charleston Division, Charleston Area Medical Center, Charleston, WV, USA.

Detection of prenatal alcohol exposure (PAE) is important for early intervention and treatment. The main purpose of this study was to compare 1.) PAE rates using the biomarker, phosphatidylethanol (PEth), in umbilical cord (UC) blood vs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08906238183047
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http://dx.doi.org/10.1016/j.reprotox.2019.01.009DOI Listing
April 2019
11 Reads

Using patient support programs for pregnancy surveillance: Current paradigm, emerging opportunity.

Reprod Toxicol 2019 03 17;84:122-124. Epub 2019 Jan 17.

Teva Pharmaceutical Industries Ltd, 12 Hatrufa St, Netanya, Israel.

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https://linkinghub.elsevier.com/retrieve/pii/S08906238183056
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http://dx.doi.org/10.1016/j.reprotox.2019.01.006DOI Listing
March 2019
9 Reads

ABCG2 c.421C>A polymorphism alters nifedipine transport to breast milk in hypertensive breastfeeding women.

Reprod Toxicol 2019 Apr 16;85:1-5. Epub 2019 Jan 16.

Department of Natural Products and Toxicology, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, Brazil. Electronic address:

Nifedipine, a known substrate to breast cancer resistance protein (ABCG2/BCRP), is used for the treatment of hypertension during breastfeeding. This study aimed to evaluate the effect of ABCG2 c.421C>A on nifedipine transfer to breast milk (BM) in hypertensive women. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.01.007DOI Listing
April 2019
3 Reads

A human embryonic stem cell-based model for benzo[a]pyrene-induced embryotoxicity.

Reprod Toxicol 2019 Apr 16;85:26-33. Epub 2019 Jan 16.

Center for Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China; Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China. Electronic address:

Benzo[a]pyrene (B[a]P) is one of the most common polycyclic aromatic hydrocarbons. In utero B[a]P exposure exerts multiple adverse effects on embryo development, although the underlying molecular mechanisms have still not been clearly elucidated. In the present study, we used human embryonic stem cell derived embryoid body (EB) as an in vitro model to investigate the embryotoxicity effects of B[a]P. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.01.008DOI Listing
April 2019
9 Reads

Sanitary pads and diapers contain higher phthalate contents than those in common commercial plastic products.

Reprod Toxicol 2019 03 16;84:114-121. Epub 2019 Jan 16.

Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, 61802, USA. Electronic address:

Sanitary pads and diapers are made of synthetic plastic materials that can potentially be released while being used. This study measured the amounts of volatile organic compounds (VOCs) (methylene chloride, toluene, and xylene) and phthalates (DBP, DEHP, DEP, and BBP) contained in sanitary pads and diapers. In sanitary pads, 5,900- and 130-fold differences of VOC and phthalate concentrations were seen among the brands. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08906238183022
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http://dx.doi.org/10.1016/j.reprotox.2019.01.005DOI Listing
March 2019
32 Reads
3.227 Impact Factor

Redox regulation of hormone sensitive lipase: Potential role in the mechanism of MEHP-induced stimulation of basal steroid synthesis in MA-10 Leydig cells.

Reprod Toxicol 2019 Apr 14;85:19-25. Epub 2019 Jan 14.

Department of Biochemistry and Genetics, Campbell University Jerry M. Wallace School of Osteopathic Medicine, Lillington, NC 27546, USA. Electronic address:

Mono-(2-ethylhexyl) phthalate (MEHP), the active metabolite of di-(2-ethylhexyl) phthalate (DEHP), is a plasticizer with endocrine disruptor activity that has been shown to stimulate basal steroid biosynthesis in Leydig cells. The mechanism by which it does so is unknown. Using MA-10 mouse tumor Leydig cells, we assessed the effects of MEHP on reactive oxygen species (ROS) levels, and on the signal transduction pathways that mobilize cholesterol. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.12.010DOI Listing
April 2019
2 Reads

Pregnancy outcomes following maternal venlafaxine use: A prospective observational comparative cohort study.

Reprod Toxicol 2019 03 11;84:108-113. Epub 2019 Jan 11.

UK Teratology Information Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK; Institute of Cellular Medicine, Newcastle University, Newcastle, UK.

Background: Venlafaxine is a serotonin noradrenaline reuptake inhibitor used to treat major depressive episodes and anxiety disorders. The primary aim of this study was to investigate spontaneous abortion risks following gestational exposure.

Methods: This prospective observational comparative cohort study utilised data collected by the UK Teratology Information Service (UKTIS) between 1995 and 2018. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.01.003DOI Listing
March 2019
4 Reads

N-acetylcysteine alleviates fluoride-induced testicular apoptosis by modulating IRE1α/JNK signaling and nuclear Nrf2 activation.

Reprod Toxicol 2019 03 8;84:98-107. Epub 2019 Jan 8.

College of Public Health, Zhengzhou University, No. 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China. Electronic address:

We previously investigated excessive fluoride exposure elicited intracellular endoplasmic reticulum (ER) stress and led to Sertoli cells dysfunction in vitro. However, the mechanisms underlying fluoride-mediated male reproductive damage in vivo remain largely unknown. Considerable evidence has now revealed ER stress is closely linked with testicular oxidative damage. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08906238183046
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http://dx.doi.org/10.1016/j.reprotox.2019.01.001DOI Listing
March 2019
18 Reads

Assessment of medication use during pregnancy by Web-based questionnaires, pharmacy records and serum screening.

Reprod Toxicol 2019 03 4;84:93-97. Epub 2019 Jan 4.

Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands. Electronic address:

Objective: To compare assessment of early pregnancy medication exposure using three methods of data collection.

Methods: Serum samples were obtained from 752 women participating in the PRegnancy and Infant DEvelopment (PRIDE) Study before gestational week 17. For 52 women using medication at the date of blood sampling according to Web-based questionnaires or pharmacy records, we analysed serum samples using untargeted liquid chromatography time-of-flight spectrometry. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08906238183049
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http://dx.doi.org/10.1016/j.reprotox.2019.01.002DOI Listing
March 2019
4 Reads

4-Methylbenzylidene-camphor inhibits proliferation and induces reactive oxygen species-mediated apoptosis of human trophoblast cells.

Reprod Toxicol 2019 03 28;84:49-58. Epub 2018 Dec 28.

Department of Biotechnology, Korea University, Seoul, 02841, Republic of Korea. Electronic address:

4-Methylbenzylidene-camphor (4-MBC) is an estrogenic compound used in a variety of personal care products and is associated with water pollution. In this study, we verified that exposure to 4-MBC suppresses the proliferation and invasiveness of the HTR8/SVneo human trophoblast cell line. Moreover, HTR8/SVneo cells treated with 4-MBC underwent apoptosis with increased DNA fragmentation. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.12.011DOI Listing
March 2019
3 Reads

Analysis of neurodevelopmental delay in children exposed in utero to hyperemesis gravidarum reveals increased reporting of autism spectrum disorder.

Reprod Toxicol 2019 03 27;84:59-64. Epub 2018 Dec 27.

Department of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

The purpose of this study was to follow up on the reporting of neurodevelopmental disorders in children exposed in utero to Hyperemesis Gravidarum (HG). This was an exploratory descriptive study whereby neurodevelopmental outcomes of 267 children delivered by 177 mothers with HG were compared to neurodevelopmental outcomes from 93 children delivered by 60 unaffected mothers. Similar to at age 8, the children (now 12) exposed in utero to HG had over 3-fold increase in odds of neurodevelopmental disorders including attention, anxiety, sensory, sleep difficulty, and social development delay/social anxiety. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.12.009DOI Listing
March 2019
4 Reads

Reproductive and hormone-related outcomes in women whose mothers were exposed in utero to diethylstilbestrol (DES): A report from the US National Cancer Institute DES Third Generation Study.

Reprod Toxicol 2019 03 27;84:32-38. Epub 2018 Dec 27.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, United States.

Background: Animal studies suggest that prenatal exposure to diethylstilbestrol (DES) causes epigenetic alterations in primordial germ cells that affect the next generation, but human studies are sparse.

Methods: We assessed hormonally mediated outcomes in third generation women whose mothers were prenatally DES-exposed and unexposed.

Results: Compared to the unexposed, DES-exposed third generation women had an increased risk of irregular menses and amenorrhea; the respective prevalence ratios and 95% confidence intervals (CI) in follow-up data were 1. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382553PMC
March 2019
4 Reads

Elevated serum chemokines are independently associated with both endometriosis and uranium exposure.

Reprod Toxicol 2019 03 21;84:26-31. Epub 2018 Dec 21.

Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, University of Cincinnati College of Medicine, Cincinnati, OH, United States. Electronic address:

Endometriosis is a complex disease impacted by the hormonal and immune systems. Cytokines and chemokines are serum biomarkers that maybe useful to develop a noninvasive disease diagnosis. Individuals in the Fernald Community Cohort were exposed to uranium, a heavy metal with radioactive properties and estrogenic potential; therefore, serum samples from women in this cohort with or without uranium and with or without endometriosis were compared for alterations in chemokine, cytokine, and matrix metalloproteinase (MMP) levels. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.12.006DOI Listing
March 2019
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Bisphenol A, Bisphenol AF, di-n-butyl phthalate, and 17β-estradiol have shared and unique dose-dependent effects on early embryo cleavage divisions and development in Xenopus laevis.

Reprod Toxicol 2019 03 21;84:65-74. Epub 2018 Dec 21.

Department of Biology, School of Science, Saint Mary's College of California, United States. Electronic address:

Bisphenol A (BPA), Bisphenol AF (BPAF), and di-n-butyl phthalate (DBP) are widespread compounds used in the production of plastics. We used Xenopus laevis to compare their effects on early embryo cell division and development. Directly after in vitro fertilizations, embryos were exposed to BPA, BPAF, DBP, or 17β-estradiol (E2) for up to 96 h. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08906238183023
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http://dx.doi.org/10.1016/j.reprotox.2018.12.005DOI Listing
March 2019
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In vitro study of Withanolide D toxicity on goat preantral follicles and its effects on the cell cycle.

Reprod Toxicol 2019 03 21;84:18-25. Epub 2018 Dec 21.

Faculty of Veterinary Medicine, Laboratory of Manipulation of Oocyte and Preantral Follicles (LAMOFOPA), State University of Ceara, Avenue Silas Munguba 1700, 60740-000, Fortaleza, CE, Brazil. Electronic address:

The Withanolide D is a chemotherapeutic potential against the human tumor cell. However, there is no report on the effect of this compound on ovarian function, especially on preantral folliculogenesis. The aim of this study was to evaluate the toxicity of a new candidate to anticancer drug, Withanolide D (WD) on morphologic integrity, development (activation and granulosa cell proliferation) and gene expression of ABCB1 protein of caprine preantral follicles. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.12.007DOI Listing
March 2019
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The effects of Bisphenol A (BPA) on sympathetic nerve fibers in the uterine wall of the domestic pig.

Reprod Toxicol 2019 03 15;84:39-48. Epub 2018 Dec 15.

Department of Internal Disease with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury, Poland.

Bisphenol A (BPA), used in the production of plastic, shows multidirectional negative effects on the living organism. BPA may affect the reproductive and nervous systems; however, its influence on the nerves supplying the uterus has not been studied. During the present study, the impact of BPA on the sympathetic nerves in the uterus was investigated using a double immunofluorescence technique. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.12.004DOI Listing
March 2019
3 Reads

Increased hepatic INSIG-SCAP-SREBP expression is associated with cholesterol metabolism disorder in assisted reproductive technology-conceived aged mice.

Reprod Toxicol 2019 03 15;84:9-17. Epub 2018 Dec 15.

Center of Reproductive Medicine, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China; Key Laboratory of Reproductive Genetics, Ministry of Education, Hangzhou 310006, China.

Although most children conceived by assisted reproductive technology (ART) are healthy, there are concerns regarding the potential long-term health implications of ART. It has been reported that alterations in insulin-induced gene (INSIG), sterol regulatory element binding protein (SREBP), and SREBP cleavage-activating protein (SCAP) are involved in cardiometabolic changes. Thus, ART mouse models were established via in vitro fertilization (IVF), intracytoplasmic injection (ICSI), and in vitro oocyte maturation (IVM). Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.12.003DOI Listing
March 2019
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Aspirin pre-treatment modulates ozone-induced fetal growth restriction and alterations in uterine blood flow in rats.

Reprod Toxicol 2019 01 5;83:63-72. Epub 2018 Dec 5.

Environmental Public Health Division, National Health & Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.

Prenatal exposure to ozone has been linked to low birth weight in people and fetal growth restriction in rats. Clinical recommendations suggest use of low dose aspirin to lower risk of preeclampsia and intrauterine growth restriction in high-risk pregnancies, yet its utility in mitigating the postnatal effects of gestational ozone exposure is unknown. The present study investigated the possibility of low dose aspirin to mitigate the effects of ozone exposure during pregnancy. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.12.002DOI Listing
January 2019
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Effects of BPA on expression of apoptotic genes and migration of ovine trophectoderm (oTr1) cells during the peri-implantation period of pregnancy.

Reprod Toxicol 2019 01 5;83:73-79. Epub 2018 Dec 5.

Department of Animal Science, Texas A&M University, College Station, TX 77843, United States; Center for Animal Biotechnology and Genomics, Texas A&M University, College Station, TX 77843, United States. Electronic address:

Bisphenol A (BPA) is an endocrine-disrupting chemical used in the manufacture of many products used daily. In the present study, the effects of BPA (1 × 10 to 1 × 10 M) on migration and on the expression of some apoptotic genes were examined in vitro using ovine trophectoderm (oTr1) primary cell line. The results revealed that BPA at 1 × 10, 1 × 10 and 1 × 10M increased migration of oTr1 cells, while 1 × 10, 1 × 10 and 1 × 10 M BPA decreased cell migration. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.12.001DOI Listing
January 2019
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Biphasic effects of perfluorooctanoic acid on steroidogenesis in mouse Leydig tumour cells.

Reprod Toxicol 2019 01 30;83:54-62. Epub 2018 Nov 30.

Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China. Electronic address:

Perfluorooctanoic acid (PFOA) is a persistent organic pollutant, which may possess endocrine disrupting properties. Herein, we investigated the possible mechanism(s) of toxicity and steroidogenesis in mouse Leydig cells. MLTC-1 (mouse Leydig tumour cells) cells were exposed to 0, 50, 100 or 200 μM PFOA for 48 h to ascertain their effects on the nuclear (membrane) receptor responses, steroidogenesis pathway and related regulated gene expression and steroid hormone secretion profiles. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.11.006DOI Listing
January 2019
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A two-generation reproductive toxicity study of sodium molybdate dihydrate administered in drinking water or diet to Sprague-Dawley rats.

Reprod Toxicol 2019 03 29;84:75-92. Epub 2018 Nov 29.

International Molybdenum Association, 325 Avenue Louise, 1050, Brussels, Belgium. Electronic address:

In an OECD Test Guideline 416 multigenerational study, groups of 24 male and 24 female Sprague-Dawley rats were administered sodium molybdate dihydrate at 0, 5, 17, or 40 mg molybdenum (Mo)/kg bw/day in the drinking water or 40 mg Mo/kg bw/day in the diet over two generations to assess reproductive toxicity. No adverse effect on reproductive function was observed at any dose level in either generation as indicated by no significant dose-related effect on estrus cycles, sperm parameters, mating, fertility, gestation, litter size, pup survival, growth or postnatal development. Systemic toxicity, including decreased body weight, food consumption (males only) and water consumption, was observed among both sexes given 40 mg Mo/kg bw/day in the diet. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.11.004DOI Listing
March 2019
5 Reads

Perfluorononanoic acid (PFNA) alters lipid accumulation in bovine blastocysts after oocyte exposure during in vitro maturation.

Reprod Toxicol 2019 03 28;84:1-8. Epub 2018 Nov 28.

Department of Clinical Sciences, Swedish University of Agricultural Science (SLU), Box 7054, SE-750 07, Uppsala, Sweden; Centre for Reproductive Biology in Uppsala, P.O Box 7054, SE-750 07, Uppsala, Sweden. Electronic address:

Perfluorononanoic acid (PFNA) is one of the perfluoroalkyl acids present in human tissues. In this study, effects on early embryo development after PFNA exposure were investigated using the bovine in vitro production system. Oocytes were exposed to PFNA during maturation in vitro (10 μg mL and 0. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.11.005DOI Listing
March 2019
2 Reads

Trichloroethylene exposure in mid-pregnancy decreased fetal weight and increased placental markers of oxidative stress in rats.

Reprod Toxicol 2019 01 20;83:38-45. Epub 2018 Nov 20.

Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI, 48201, USA. Electronic address:

Although epidemiology studies have associated maternal trichloroethylene (TCE) exposure with decreased birth weight and preterm birth, mechanistic explanations for these associations are currently lacking. We hypothesized that TCE targets the placenta with adverse consequences for pregnancy outcomes. Pregnant Wistar rats were exposed orally to vehicle or 480 mg TCE/kg body weight from gestational days (gd) 6-16, and tissues were collected on gd 16. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404769PMC
January 2019
15 Reads

Structural characterization of potential endocrine disrupting activity of alternate plasticizers di-(2-ethylhexyl) adipate (DEHA), acetyl tributyl citrate (ATBC) and 2,2,4-trimethyl 1,3-pentanediol diisobutyrate (TPIB) with human sex hormone-binding globulin.

Reprod Toxicol 2019 01 20;83:46-53. Epub 2018 Nov 20.

King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

Plasticizers are chemical compounds used to increase the softness and fluidity of polymer materials. Phthalate compounds constitute the most common class of compounds used as plasticizers. However, phthalate plasticizers, especially the predominant di(2-ethylhexyl)phthalate, have been shown to have adverse effects on environment and human health. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.11.003DOI Listing
January 2019
17 Reads

The effects and possible mechanisms of triclosan on steroidogenesis in primary rat granulosa cells.

Reprod Toxicol 2019 01 14;83:28-37. Epub 2018 Nov 14.

Department of Developmental and Behavioral Pediatrics, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Ministry of Education Shanghai Key Laboratory of Children's Environmental Health, Shanghai, China. Electronic address:

Background: Triclosan (TCS) has been detected in human tissues. It can disrupt steroidogenesis in vivo. The study on the effects of TCS on ovarian granulosa cells was lacking. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08906238183014
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http://dx.doi.org/10.1016/j.reprotox.2018.11.001DOI Listing
January 2019
17 Reads

Tri-ortho-cresyl phosphate (TOCP) induced ovarian failure in mice is related to the Hippo signaling pathway disruption.

Reprod Toxicol 2019 01 13;83:21-27. Epub 2018 Nov 13.

Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330031, China; Jiangxi Key Laboratory of Reproductive Physiology and Pathology, Nanchang University, Nanchang, Jiangxi 330031, China. Electronic address:

As a plasticizer widely used in society, tri-ortho-cresyl phosphate (TOCP) is reported to inhibit spermatogenesis and growth of spermatogonial stem cells. However, its effects on female reproductive system are virtually unknown. The present study investigated the effects of TOCP on ovarian follicle development by using mouse model of chronic TOCP exposure, and examined the expression of the core components of the Hippo pathway, which had been proven to be crucial for ovarian follicle development. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.10.007DOI Listing
January 2019
4 Reads