3,107 results match your criteria Reproductive Toxicology[Journal]


Dietary exposure to mycotoxin zearalenone (ZEA) during post-implantation adversely affects placental development in mice.

Reprod Toxicol 2019 Feb 14. Epub 2019 Feb 14.

Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA; Interdisciplinary Toxicology Program, University of Georgia, Athens, Georgia, USA. Electronic address:

Zearalenone (ZEA) is a common food contaminant (ppb˜ppm) derived from Fusarium fungi. With its estrogenicity and potential chronic exposure, ZEA poses a risk to pregnancy. Our previous studies implied post-implantational lethality by ZEA. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.01.010DOI Listing
February 2019

Prenatal exposure to pyrrolizidine alkaloids induced hepatotoxicity and pulmonary injury in fetal rats.

Reprod Toxicol 2019 Feb 13. Epub 2019 Feb 13.

Department of pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Diseases, Wuhan 430071, China. Electronic address:

Hepatic and pulmonary toxicity in fetal rats induced by pyrrolizidine alkaloids (PAs) was investigated. Retrorsine (RTS) or monocrotaline (MCT) was intragastrically administered during pregnancy. The reduction of body and tail lengths was consistent with body weight loss in PA-exposed fetuses, and pathological lesions in liver and lung were observed only in fetuses. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.006DOI Listing
February 2019

Trehalose restores functional autophagy suppressed by high glucose.

Reprod Toxicol 2019 Feb 12. Epub 2019 Feb 12.

Department of Obstetrics, Gynecology & Reproductive Sciences, Baltimore, Maryland, USA; Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA. Electronic address:

Autophagy is required for neurulation, and autophagy activators with minimal toxicity, such as the natural compound trehalose, a nonreducing disaccharide, possess high therapeutic value. To determine whether trehalose directly induces autophagy, FITC-labeled trehalose was used for tracing its presence in autophagosome complexes. Trehalose was as potent as rapamycin and starvation in inducing de novo autophagosome formation and increasing autophagosome flux in GFP-LC3 reporter cells and C17. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.005DOI Listing
February 2019
1 Read

Pregnancy outcomes following quinolone and fluoroquinolone exposure during pregnancy: A systematic review and meta-analysis.

Reprod Toxicol 2019 Feb 7. Epub 2019 Feb 7.

Izmir Katip Celebi University, Faculty of Medicine, Department of Pharmacology Izmir, Turkey; Terafar, Izmir Katip Celebi University Teratology Information, Training and Research Center, Izmir, Turkey.

Objective: To investigate whether maternal exposure to quinolones, fluoroquinolones and specifically ciprofloxacin is associated with major malformations and other adverse pregnancy outcomes.

Methods: MEDLINE/PubMed, Embase and Reprotox® databases were searched. Observational studies with an exposed and control group were included. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.002DOI Listing
February 2019
1 Read

MITOCHONDRIAL-RELATED GENE ASSOCIATED TO OBESITY CAN BE MODULATED BY IN UTERO HYPERGLYCEMIC ENVIRONMENT.

Reprod Toxicol 2019 Feb 6. Epub 2019 Feb 6.

UNESP, São Paulo State University, Botucatu Medical School, Department of Pathology, Botucatu, São Paulo, Brazil; UNESP, São Paulo State University, Institute of Biosciences, Department of Genetics, Botucatu, São Paulo, Brazil.

We investigated whether mitochondrial-related genes and proteins are modulated by hyperglycemia promoted by gestational diabetes (GDM), thereby increasing neonate obesity predisposition. 19 healthy pregnant women, 16 pregnant women with GDM and their respective neonates were enrolled. Additionally, 19 obese and 19 eutrophic adults were recruited as a reference population. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.001DOI Listing
February 2019

Adverse outcome pathway of developmental neurotoxicity resulting from prenatal exposures to cannabis contaminated with organophosphate pesticide residues.

Reprod Toxicol 2019 Jan 19;85:12-18. Epub 2019 Jan 19.

Department of Pesticide Regulation, California Environmental Protection Agency, Sacramento, 1001 I Street, Sacramento, CA 95812, United States.

There is growing concern that increased use of medical and recreational cannabis may result in increased exposure to contaminants on the cannabis, such as pesticides. Several states are moving towards implementing robust regulation of the sales, cultivation, and manufacture of cannabis products. However, there are challenges with creating health-protective regulations in an industry that, to date, has been largely unregulated. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.01.004DOI Listing
January 2019
1 Read

Screening for prenatal alcohol exposure and corresponding short-term neonatal outcomes.

Reprod Toxicol 2019 Jan 18;85:6-11. Epub 2019 Jan 18.

Department of Obstetrics and Gynecology, West Virginia University-Charleston Division, Charleston Area Medical Center, Charleston, WV, USA.

Detection of prenatal alcohol exposure (PAE) is important for early intervention and treatment. The main purpose of this study was to compare 1.) PAE rates using the biomarker, phosphatidylethanol (PEth), in umbilical cord (UC) blood vs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08906238183047
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http://dx.doi.org/10.1016/j.reprotox.2019.01.009DOI Listing
January 2019
5 Reads

Using patient support programs for pregnancy surveillance: Current paradigm, emerging opportunity.

Reprod Toxicol 2019 Jan 17;84:122-124. Epub 2019 Jan 17.

Teva Pharmaceutical Industries Ltd, 12 Hatrufa St, Netanya, Israel.

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http://dx.doi.org/10.1016/j.reprotox.2019.01.006DOI Listing
January 2019
4 Reads

ABCG2 c.421C>A polymorphism alters nifedipine transport to breast milk in hypertensive breastfeeding women.

Reprod Toxicol 2019 Jan 16;85:1-5. Epub 2019 Jan 16.

Department of Natural Products and Toxicology, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, Brazil. Electronic address:

Nifedipine, a known substrate to breast cancer resistance protein (ABCG2/BCRP), is used for the treatment of hypertension during breastfeeding. This study aimed to evaluate the effect of ABCG2 c.421C>A on nifedipine transfer to breast milk (BM) in hypertensive women. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.01.007DOI Listing
January 2019
1 Read

A human embryonic stem cell-based model for benzo[a]pyrene-induced embryotoxicity.

Reprod Toxicol 2019 Jan 16;85:26-33. Epub 2019 Jan 16.

Center for Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China; Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China. Electronic address:

Benzo[a]pyrene (B[a]P) is one of the most common polycyclic aromatic hydrocarbons. In utero B[a]P exposure exerts multiple adverse effects on embryo development, although the underlying molecular mechanisms have still not been clearly elucidated. In the present study, we used human embryonic stem cell derived embryoid body (EB) as an in vitro model to investigate the embryotoxicity effects of B[a]P. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.01.008DOI Listing
January 2019
1 Read

Sanitary pads and diapers contain higher phthalate contents than those in common commercial plastic products.

Reprod Toxicol 2019 Jan 16;84:114-121. Epub 2019 Jan 16.

Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, 61802, USA. Electronic address:

Sanitary pads and diapers are made of synthetic plastic materials that can potentially be released while being used. This study measured the amounts of volatile organic compounds (VOCs) (methylene chloride, toluene, and xylene) and phthalates (DBP, DEHP, DEP, and BBP) contained in sanitary pads and diapers. In sanitary pads, 5,900- and 130-fold differences of VOC and phthalate concentrations were seen among the brands. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08906238183022
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http://dx.doi.org/10.1016/j.reprotox.2019.01.005DOI Listing
January 2019
21 Reads
3.227 Impact Factor

Redox regulation of hormone sensitive lipase: Potential role in the mechanism of MEHP-induced stimulation of basal steroid synthesis in MA-10 Leydig cells.

Reprod Toxicol 2019 Jan 14;85:19-25. Epub 2019 Jan 14.

Department of Biochemistry and Genetics, Campbell University Jerry M. Wallace School of Osteopathic Medicine, Lillington, NC 27546, USA. Electronic address:

Mono-(2-ethylhexyl) phthalate (MEHP), the active metabolite of di-(2-ethylhexyl) phthalate (DEHP), is a plasticizer with endocrine disruptor activity that has been shown to stimulate basal steroid biosynthesis in Leydig cells. The mechanism by which it does so is unknown. Using MA-10 mouse tumor Leydig cells, we assessed the effects of MEHP on reactive oxygen species (ROS) levels, and on the signal transduction pathways that mobilize cholesterol. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.12.010DOI Listing
January 2019
2 Reads

Pregnancy outcomes following maternal venlafaxine use: A prospective observational comparative cohort study.

Reprod Toxicol 2019 Jan 11;84:108-113. Epub 2019 Jan 11.

UK Teratology Information Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK; Institute of Cellular Medicine, Newcastle University, Newcastle, UK.

Background: Venlafaxine is a serotonin noradrenaline reuptake inhibitor used to treat major depressive episodes and anxiety disorders. The primary aim of this study was to investigate spontaneous abortion risks following gestational exposure.

Methods: This prospective observational comparative cohort study utilised data collected by the UK Teratology Information Service (UKTIS) between 1995 and 2018. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.01.003DOI Listing
January 2019
3 Reads

N-acetylcysteine alleviates fluoride-induced testicular apoptosis by modulating IRE1α/JNK signaling and nuclear Nrf2 activation.

Reprod Toxicol 2019 Jan 8;84:98-107. Epub 2019 Jan 8.

College of Public Health, Zhengzhou University, No. 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China. Electronic address:

We previously investigated excessive fluoride exposure elicited intracellular endoplasmic reticulum (ER) stress and led to Sertoli cells dysfunction in vitro. However, the mechanisms underlying fluoride-mediated male reproductive damage in vivo remain largely unknown. Considerable evidence has now revealed ER stress is closely linked with testicular oxidative damage. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08906238183046
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http://dx.doi.org/10.1016/j.reprotox.2019.01.001DOI Listing
January 2019
14 Reads

Assessment of medication use during pregnancy by Web-based questionnaires, pharmacy records and serum screening.

Reprod Toxicol 2019 Jan 4;84:93-97. Epub 2019 Jan 4.

Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands. Electronic address:

Objective: To compare assessment of early pregnancy medication exposure using three methods of data collection.

Methods: Serum samples were obtained from 752 women participating in the PRegnancy and Infant DEvelopment (PRIDE) Study before gestational week 17. For 52 women using medication at the date of blood sampling according to Web-based questionnaires or pharmacy records, we analysed serum samples using untargeted liquid chromatography time-of-flight spectrometry. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08906238183049
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http://dx.doi.org/10.1016/j.reprotox.2019.01.002DOI Listing
January 2019
3 Reads

4-Methylbenzylidene-camphor inhibits proliferation and induces reactive oxygen species-mediated apoptosis of human trophoblast cells.

Reprod Toxicol 2018 Dec 28;84:49-58. Epub 2018 Dec 28.

Department of Biotechnology, Korea University, Seoul, 02841, Republic of Korea. Electronic address:

4-Methylbenzylidene-camphor (4-MBC) is an estrogenic compound used in a variety of personal care products and is associated with water pollution. In this study, we verified that exposure to 4-MBC suppresses the proliferation and invasiveness of the HTR8/SVneo human trophoblast cell line. Moreover, HTR8/SVneo cells treated with 4-MBC underwent apoptosis with increased DNA fragmentation. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.12.011DOI Listing
December 2018
1 Read

Analysis of neurodevelopmental delay in children exposed in utero to hyperemesis gravidarum reveals increased reporting of autism spectrum disorder.

Reprod Toxicol 2018 Dec 27;84:59-64. Epub 2018 Dec 27.

Department of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

The purpose of this study was to follow up on the reporting of neurodevelopmental disorders in children exposed in utero to Hyperemesis Gravidarum (HG). This was an exploratory descriptive study whereby neurodevelopmental outcomes of 267 children delivered by 177 mothers with HG were compared to neurodevelopmental outcomes from 93 children delivered by 60 unaffected mothers. Similar to at age 8, the children (now 12) exposed in utero to HG had over 3-fold increase in odds of neurodevelopmental disorders including attention, anxiety, sensory, sleep difficulty, and social development delay/social anxiety. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.12.009DOI Listing
December 2018
3 Reads

Reproductive and hormone-related outcomes in women whose mothers were exposed in utero to diethylstilbestrol (DES): A report from the US National Cancer Institute DES Third Generation Study.

Reprod Toxicol 2018 Dec 27;84:32-38. Epub 2018 Dec 27.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, United States.

Background: Animal studies suggest that prenatal exposure to diethylstilbestrol (DES) causes epigenetic alterations in primordial germ cells that affect the next generation, but human studies are sparse.

Methods: We assessed hormonally mediated outcomes in third generation women whose mothers were prenatally DES-exposed and unexposed.

Results: Compared to the unexposed, DES-exposed third generation women had an increased risk of irregular menses and amenorrhea; the respective prevalence ratios and 95% confidence intervals (CI) in follow-up data were 1. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.12.008DOI Listing
December 2018
3 Reads

Elevated serum chemokines are independently associated with both endometriosis and uranium exposure.

Reprod Toxicol 2018 Dec 21;84:26-31. Epub 2018 Dec 21.

Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, University of Cincinnati College of Medicine, Cincinnati, OH, United States. Electronic address:

Endometriosis is a complex disease impacted by the hormonal and immune systems. Cytokines and chemokines are serum biomarkers that maybe useful to develop a noninvasive disease diagnosis. Individuals in the Fernald Community Cohort were exposed to uranium, a heavy metal with radioactive properties and estrogenic potential; therefore, serum samples from women in this cohort with or without uranium and with or without endometriosis were compared for alterations in chemokine, cytokine, and matrix metalloproteinase (MMP) levels. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.12.006DOI Listing
December 2018
1 Read

Bisphenol A, Bisphenol AF, di-n-butyl phthalate, and 17β-estradiol have shared and unique dose-dependent effects on early embryo cleavage divisions and development in Xenopus laevis.

Reprod Toxicol 2018 Dec 21;84:65-74. Epub 2018 Dec 21.

Department of Biology, School of Science, Saint Mary's College of California, United States. Electronic address:

Bisphenol A (BPA), Bisphenol AF (BPAF), and di-n-butyl phthalate (DBP) are widespread compounds used in the production of plastics. We used Xenopus laevis to compare their effects on early embryo cell division and development. Directly after in vitro fertilizations, embryos were exposed to BPA, BPAF, DBP, or 17β-estradiol (E2) for up to 96 h. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08906238183023
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http://dx.doi.org/10.1016/j.reprotox.2018.12.005DOI Listing
December 2018
6 Reads

In vitro study of Withanolide D toxicity on goat preantral follicles and its effects on the cell cycle.

Reprod Toxicol 2018 Dec 21;84:18-25. Epub 2018 Dec 21.

Faculty of Veterinary Medicine, Laboratory of Manipulation of Oocyte and Preantral Follicles (LAMOFOPA), State University of Ceara, Avenue Silas Munguba 1700, 60740-000, Fortaleza, CE, Brazil. Electronic address:

The Withanolide D is a chemotherapeutic potential against the human tumor cell. However, there is no report on the effect of this compound on ovarian function, especially on preantral folliculogenesis. The aim of this study was to evaluate the toxicity of a new candidate to anticancer drug, Withanolide D (WD) on morphologic integrity, development (activation and granulosa cell proliferation) and gene expression of ABCB1 protein of caprine preantral follicles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08906238183056
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http://dx.doi.org/10.1016/j.reprotox.2018.12.007DOI Listing
December 2018
6 Reads

The effects of Bisphenol A (BPA) on sympathetic nerve fibers in the uterine wall of the domestic pig.

Reprod Toxicol 2018 Dec 15;84:39-48. Epub 2018 Dec 15.

Department of Internal Disease with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury, Poland.

Bisphenol A (BPA), used in the production of plastic, shows multidirectional negative effects on the living organism. BPA may affect the reproductive and nervous systems; however, its influence on the nerves supplying the uterus has not been studied. During the present study, the impact of BPA on the sympathetic nerves in the uterus was investigated using a double immunofluorescence technique. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.12.004DOI Listing
December 2018
3 Reads

Increased hepatic INSIG-SCAP-SREBP expression is associated with cholesterol metabolism disorder in assisted reproductive technology-conceived aged mice.

Reprod Toxicol 2018 Dec 15;84:9-17. Epub 2018 Dec 15.

Center of Reproductive Medicine, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China; Key Laboratory of Reproductive Genetics, Ministry of Education, Hangzhou 310006, China.

Although most children conceived by assisted reproductive technology (ART) are healthy, there are concerns regarding the potential long-term health implications of ART. It has been reported that alterations in insulin-induced gene (INSIG), sterol regulatory element binding protein (SREBP), and SREBP cleavage-activating protein (SCAP) are involved in cardiometabolic changes. Thus, ART mouse models were established via in vitro fertilization (IVF), intracytoplasmic injection (ICSI), and in vitro oocyte maturation (IVM). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08906238183018
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http://dx.doi.org/10.1016/j.reprotox.2018.12.003DOI Listing
December 2018
2 Reads

Aspirin pre-treatment modulates ozone-induced fetal growth restriction and alterations in uterine blood flow in rats.

Reprod Toxicol 2019 Jan 5;83:63-72. Epub 2018 Dec 5.

Environmental Public Health Division, National Health & Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.

Prenatal exposure to ozone has been linked to low birth weight in people and fetal growth restriction in rats. Clinical recommendations suggest use of low dose aspirin to lower risk of preeclampsia and intrauterine growth restriction in high-risk pregnancies, yet its utility in mitigating the postnatal effects of gestational ozone exposure is unknown. The present study investigated the possibility of low dose aspirin to mitigate the effects of ozone exposure during pregnancy. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.12.002DOI Listing
January 2019
2 Reads

Effects of BPA on expression of apoptotic genes and migration of ovine trophectoderm (oTr1) cells during the peri-implantation period of pregnancy.

Reprod Toxicol 2019 Jan 5;83:73-79. Epub 2018 Dec 5.

Department of Animal Science, Texas A&M University, College Station, TX 77843, United States; Center for Animal Biotechnology and Genomics, Texas A&M University, College Station, TX 77843, United States. Electronic address:

Bisphenol A (BPA) is an endocrine-disrupting chemical used in the manufacture of many products used daily. In the present study, the effects of BPA (1 × 10 to 1 × 10 M) on migration and on the expression of some apoptotic genes were examined in vitro using ovine trophectoderm (oTr1) primary cell line. The results revealed that BPA at 1 × 10, 1 × 10 and 1 × 10M increased migration of oTr1 cells, while 1 × 10, 1 × 10 and 1 × 10 M BPA decreased cell migration. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.12.001DOI Listing
January 2019
1 Read

Biphasic effects of perfluorooctanoic acid on steroidogenesis in mouse Leydig tumour cells.

Reprod Toxicol 2019 Jan 30;83:54-62. Epub 2018 Nov 30.

Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China. Electronic address:

Perfluorooctanoic acid (PFOA) is a persistent organic pollutant, which may possess endocrine disrupting properties. Herein, we investigated the possible mechanism(s) of toxicity and steroidogenesis in mouse Leydig cells. MLTC-1 (mouse Leydig tumour cells) cells were exposed to 0, 50, 100 or 200 μM PFOA for 48 h to ascertain their effects on the nuclear (membrane) receptor responses, steroidogenesis pathway and related regulated gene expression and steroid hormone secretion profiles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08906238183049
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http://dx.doi.org/10.1016/j.reprotox.2018.11.006DOI Listing
January 2019
11 Reads

A two-generation reproductive toxicity study of sodium molybdate dihydrate administered in drinking water or diet to Sprague-Dawley rats.

Reprod Toxicol 2018 Nov 29;84:75-92. Epub 2018 Nov 29.

International Molybdenum Association, 325 Avenue Louise, 1050, Brussels, Belgium. Electronic address:

In an OECD Test Guideline 416 multigenerational study, groups of 24 male and 24 female Sprague-Dawley rats were administered sodium molybdate dihydrate at 0, 5, 17, or 40 mg molybdenum (Mo)/kg bw/day in the drinking water or 40 mg Mo/kg bw/day in the diet over two generations to assess reproductive toxicity. No adverse effect on reproductive function was observed at any dose level in either generation as indicated by no significant dose-related effect on estrus cycles, sperm parameters, mating, fertility, gestation, litter size, pup survival, growth or postnatal development. Systemic toxicity, including decreased body weight, food consumption (males only) and water consumption, was observed among both sexes given 40 mg Mo/kg bw/day in the diet. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.11.004DOI Listing
November 2018
2 Reads

Perfluorononanoic acid (PFNA) alters lipid accumulation in bovine blastocysts after oocyte exposure during in vitro maturation.

Reprod Toxicol 2018 Nov 28;84:1-8. Epub 2018 Nov 28.

Department of Clinical Sciences, Swedish University of Agricultural Science (SLU), Box 7054, SE-750 07, Uppsala, Sweden; Centre for Reproductive Biology in Uppsala, P.O Box 7054, SE-750 07, Uppsala, Sweden. Electronic address:

Perfluorononanoic acid (PFNA) is one of the perfluoroalkyl acids present in human tissues. In this study, effects on early embryo development after PFNA exposure were investigated using the bovine in vitro production system. Oocytes were exposed to PFNA during maturation in vitro (10 μg mL and 0. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.11.005DOI Listing
November 2018
2 Reads

Trichloroethylene exposure in mid-pregnancy decreased fetal weight and increased placental markers of oxidative stress in rats.

Reprod Toxicol 2019 Jan 20;83:38-45. Epub 2018 Nov 20.

Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI, 48201, USA. Electronic address:

Although epidemiology studies have associated maternal trichloroethylene (TCE) exposure with decreased birth weight and preterm birth, mechanistic explanations for these associations are currently lacking. We hypothesized that TCE targets the placenta with adverse consequences for pregnancy outcomes. Pregnant Wistar rats were exposed orally to vehicle or 480 mg TCE/kg body weight from gestational days (gd) 6-16, and tissues were collected on gd 16. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.11.002DOI Listing
January 2019
11 Reads

Structural characterization of potential endocrine disrupting activity of alternate plasticizers di-(2-ethylhexyl) adipate (DEHA), acetyl tributyl citrate (ATBC) and 2,2,4-trimethyl 1,3-pentanediol diisobutyrate (TPIB) with human sex hormone-binding globulin.

Reprod Toxicol 2019 Jan 20;83:46-53. Epub 2018 Nov 20.

King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

Plasticizers are chemical compounds used to increase the softness and fluidity of polymer materials. Phthalate compounds constitute the most common class of compounds used as plasticizers. However, phthalate plasticizers, especially the predominant di(2-ethylhexyl)phthalate, have been shown to have adverse effects on environment and human health. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.11.003DOI Listing
January 2019
12 Reads

The effects and possible mechanisms of triclosan on steroidogenesis in primary rat granulosa cells.

Reprod Toxicol 2019 Jan 14;83:28-37. Epub 2018 Nov 14.

Department of Developmental and Behavioral Pediatrics, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Ministry of Education Shanghai Key Laboratory of Children's Environmental Health, Shanghai, China. Electronic address:

Background: Triclosan (TCS) has been detected in human tissues. It can disrupt steroidogenesis in vivo. The study on the effects of TCS on ovarian granulosa cells was lacking. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08906238183014
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http://dx.doi.org/10.1016/j.reprotox.2018.11.001DOI Listing
January 2019
8 Reads

Tri-ortho-cresyl phosphate (TOCP) induced ovarian failure in mice is related to the Hippo signaling pathway disruption.

Reprod Toxicol 2019 Jan 13;83:21-27. Epub 2018 Nov 13.

Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330031, China; Jiangxi Key Laboratory of Reproductive Physiology and Pathology, Nanchang University, Nanchang, Jiangxi 330031, China. Electronic address:

As a plasticizer widely used in society, tri-ortho-cresyl phosphate (TOCP) is reported to inhibit spermatogenesis and growth of spermatogonial stem cells. However, its effects on female reproductive system are virtually unknown. The present study investigated the effects of TOCP on ovarian follicle development by using mouse model of chronic TOCP exposure, and examined the expression of the core components of the Hippo pathway, which had been proven to be crucial for ovarian follicle development. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.10.007DOI Listing
January 2019
3 Reads

Aqueous extract of Eruca Sativa protects human spermatozoa from mitochondrial failure due to bisphenol A exposure.

Reprod Toxicol 2018 Dec 25;82:103-110. Epub 2018 Oct 25.

Department of Medicine and Unit of Andrology and Reproductive Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy. Electronic address:

Medicinal plants are suggested to counteract health disorders from chemical pollutants. Here we explored the possible ameliorative effect of Eruca sativa aqueous extract (ESAE) on in vitro acute functional disturbance induced by Bisphenol A (BPA), a disruptor model in human spermatozoa. Phytochemical screening, high performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS) analysis and 2,2'-azino-bis [3-ethylbenzthiazoline-6-sulphonic acid]/α,α-diphenyl-β-picrylhydrazyl (ABTS/DPPH) tests disclosed antioxidant properties of ESAE, ascribed to polyphenols and flavonoids. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08906238183024
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http://dx.doi.org/10.1016/j.reprotox.2018.10.008DOI Listing
December 2018
8 Reads
3.230 Impact Factor

Effects of two environmental endocrine disruptors di-n-butyl phthalate (DBP) and mono-n-butyl phthalate (MBP) on human sperm functions in vitro.

Reprod Toxicol 2019 Jan 2;83:1-7. Epub 2018 Nov 2.

Department of Urology and Reproductive Center, The Sixth Affiliated Hospital of Wenzhou Medical University, People's Hospital of Lishui, Lishui, Zhejiang 323000, China. Electronic address:

Di-n-butyl phthalate (DBP), a plastic-derived, endocrine-disrupting chemical, is regarded as a male reproductive toxicant. In this study, we investigated the in vitro actions of DBP and mono-n-butyl phthalate (MBP, the main metabolite of DBP) on human sperm functions. Human sperm were treated with DBP (2 nM-6 μM), MBP (1 nM-3 μM), and a mixture of DBP and MBP in vitro. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.10.011DOI Listing
January 2019
4 Reads

Puberty exposure to cigarette smoke extract impairs adult spermatogenesis in the mouse.

Reprod Toxicol 2019 Jan 2;83:8-13. Epub 2018 Nov 2.

Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, No. 63 Duobao Rd, Guangzhou, 510150, China; Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, No. 63 Duobao Rd, Guangzhou, 510150, China. Electronic address:

Epidemiological studies suggested that exposure to cigarette smoke early in life is associated with long-term health risks. Using a nuclear factor erythroid 2-related factor 2 (Nrf2) knockout (KO) mouse model, we found the sperm concentration and sperm motility were significantly lower in mice exposed to cigarette smoke extract (CSE) beginning at 4 weeks of age compared to 8 week-old mice. Additionally, CSE exposure significantly decreased in vitro fertilization (IVF) and blastocyst rates in the Nrf2 KO mice compared to the wild-type (WT) mice. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.10.012DOI Listing
January 2019
13 Reads

First trimester ondansetron exposure and risk of structural birth defects.

Reprod Toxicol 2019 Jan 29;83:14-20. Epub 2018 Oct 29.

Department of Community and Family Health, College of Public Health, University of South Florida, 13201 Bruce B Downs Blvd, Tampa, FL 33612, USA.

This study investigates risk of specific structural birth defects associated with ondansetron exposure during the first trimester in a large US commercially-insured population. Medical claims data were obtained from Truven Health Analytics for 864,083 mother-infant pairs from 2000 to 2014. Logistic regression was used to measure the association between first trimester exposure to ondansetron and risk of cardiac defects, orofacial clefts and other specific structural defects in offspring. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.10.010DOI Listing
January 2019
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Bisphenol-A impairs cellular function and alters DNA methylation of stress pathway genes in first trimester trophoblast cells.

Reprod Toxicol 2018 Dec 21;82:72-79. Epub 2018 Oct 21.

Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address:

Humans are exposed to Bisphenol A (BPA) from the consumer products and plastic substances. However, impacts of low levels of BPA exposure on placental developmental processes such as first trimester trophoblast cell growth, angiogenesis and epigenetic modifications are not well studied. Low concentration of BPA (1 nM) affected cell proliferation of human placental first trimester trophoblasts using a model cell, HTR8/SVneo. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.10.009DOI Listing
December 2018
3 Reads
3.230 Impact Factor

Toxicological effects of 3-methyl-4-nitrophenol on mouse ovarian and testicular cell proliferation, apoptosis and oocyte maturation.

Reprod Toxicol 2018 Dec 21;82:94-102. Epub 2018 Oct 21.

College of Biological Science and Technology, Beijing Forestry University, Beijing, 100083, People's Republic of China. Electronic address:

The aim of the present study was to reveal the effects of 3-methyl-4-nitrophenol (PNMC) on mouse gonadal cell proliferation and apoptosis. Immature female and male mice were intramuscularly injected with 100 mg/kg PNMC or vehicle every five days. One-month later, ovarian rather than testicular weights were significantly decreased. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.10.005DOI Listing
December 2018
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Comparison of congenital malformations among babies born after administration of letrozole or clomiphene citrate for infertility treatment in a Korean cohort.

Reprod Toxicol 2018 Dec 16;82:88-93. Epub 2018 Oct 16.

Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Republic of Korea; Institute of Women's Life Medical Science, Seodaemun-gu, Seoul, Republic of Korea. Electronic address:

This retrospective study investigated and compared the incidence of congenital foetal anomalies after letrozole versus clomiphene citrate (CC) administration for infertility treatment. Data from 142 newborns were included: letrozole group, n = 83; CC group, n = 61. Congenital anomalies were found in 7. Read More

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December 2018
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Transcript profiling in the testes and prostates of postnatal day 30 Sprague-Dawley rats exposed prenatally and lactationally to 2-hydroxy-4-methoxybenzophenone.

Reprod Toxicol 2018 Dec 11;82:111-123. Epub 2018 Oct 11.

Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States.

2-hydroxy-4-methoxybenzophenone (HMB) is an ultraviolet light-absorbing compound that is used in sunscreens, cosmetics and plastics. HMB has been reported to have weak estrogenic activity by in vivo and in vitro studies, making it a chemical with potential reproductive concern. To explore if prenatal and lactational HMB exposure alters gene expression profiles of the developing reproductive organs, we performed microarray analysis using the prostate and testis of postnatal day (PND) 30 male Sprague-Dawley rats offspring exposed to 0, 3000, or 30,000 ppm of HMB from gestational day 6 through PND 21. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.10.001DOI Listing
December 2018
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Toxicological and nutritional status of trace elements in hair of women with in vitro fertilization (IVF) pregnancy and their 9-month-old children.

Reprod Toxicol 2018 Dec 11;82:50-56. Epub 2018 Oct 11.

Laboratory for Cognitive Investigations and Behavioural Genetics, Tomsk State University, Tomsk, Russia; Goldsmiths, University of London, London, UK.

The objective of the present study was to assess toxic and nutritional trace element and mineral status in hair of women with IVF pregnancy and their children. Inductively-coupled plasma mass-spectrometry was used to assess hair trace element levels of 50 women with IVF pregnancy and 158 controls with spontaneous pregnancy and their children. Women with IVF pregnancy were characterized by significantly elevated hair As, Hg, Li, K, Na, and reduced Fe, Si, and Zn contents. Read More

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December 2018
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Asymmetric development of the male mouse mammary gland and its response to a prenatal or postnatal estrogen challenge.

Reprod Toxicol 2018 Dec 11;82:63-71. Epub 2018 Oct 11.

Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, United States. Electronic address:

The CD-1 mouse mammary gland is sexually dimorphic, with males lacking nipples. Recent studies have revealed that the underlying epithelium in the male mammary gland is sensitive to estrogenic environmental chemicals. In ongoing investigations, we observed asymmetric morphology in the left and right male mouse mammary glands. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.10.003DOI Listing
December 2018
4 Reads

Nitrogen mustard exposure perturbs oocyte mitochondrial physiology and alters reproductive outcomes.

Reprod Toxicol 2018 Dec 9;82:80-87. Epub 2018 Oct 9.

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA. Electronic address:

Nitrogen mustard (NM) is an alkylating chemical warfare agent, and its derivatives are used in chemotherapy. Alkylating agents can cause mitochondrial damage, so exposed females may transmit damaged genomes to their children, since mitochondria are maternally inherited and oocytes are not thought to undergo mitophagy (Boudoures et al. [1]). Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.10.002DOI Listing
December 2018
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A mechanistic model for thiol redox dynamics in the organogenesis stage rat conceptus.

Reprod Toxicol 2018 Dec 5;82:38-49. Epub 2018 Oct 5.

Department of Environmental Health Sciences, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109-2029, USA.

Precise control of the glutathione/glutathione disulfide (GSH/GSSG) redox balance is vital for the developing embryo, but regulatory mechanisms are poorly understood. We developed a novel, mechanistic mass-balance model for GSH metabolism in the organogenesis stage (gestational day 10.0-11. Read More

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December 2018
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Presence of human herpes virus 1-thymidine kinase in testis of azoospermic infertile herpes-infected patients.

Reprod Toxicol 2018 Dec 30;82:57-62. Epub 2018 Sep 30.

Division of Life Science, Graduate School of Agriculture, Meiji University, Kawasaki, Kanagawa 214-8571, Japan; Institute for Endocrinology, Meiji University, Kawasaki, Kanagawa 214-8571, Japan; Laboratory of Molecular Biology and Gene Regulation, Department of Life Science, Meiji University, Kawasaki, Kanagawa 214-8571, Japan. Electronic address:

Infection with human herpes virus 1 (HHV1) is a suspected cause of human male infertility. However, the correlation between HHV1 infection and infertility is still unclear. We have previously generated transgenic rats that ectopically express the HHV1 thymidine kinase gene (HHV1-TK) in post-meiotic spermatids and found they had aberrant spermatogenesis and infertility. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.09.007DOI Listing
December 2018
1 Read
3.227 Impact Factor

Exposure to a glyphosate-based herbicide formulation, but not glyphosate alone, has only minor effects on adult rat testis.

Reprod Toxicol 2018 Dec 27;82:25-31. Epub 2018 Sep 27.

Division of Diet, Disease Prevention and Toxicology, National Food Institute, Technical University of Denmark, Kgs. Lyngby, DK-2800, Denmark. Electronic address:

Glyphosate has been suggested to be an endocrine disrupting chemical capable of disrupting male reproduction. There are conflicting data, however, with studies reporting effects from exposure to either glyphosate alone or to herbicide formulations, making comparisons difficult. We assessed rat testis histopathology and androgen function following two weeks exposure to either glyphosate at 2. Read More

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December 2018
3 Reads

Serum bisphenol A concentrations correlate with serum testosterone levels in women with polycystic ovary syndrome.

Reprod Toxicol 2018 Dec 25;82:32-37. Epub 2018 Sep 25.

Department of Analytical Chemistry, Chemical Faculty, Gdańsk University of Technology, Narutowicza 11/12, 80-223 Gdańsk, Poland.

The aim of this study was to determine serum bisphenol A (BPA) concentrations using high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS) in women with polycystic ovary syndrome (PCOS) (n = 106, age range 18-40 yrs) and to evaluate its potential impact on their hormonal and metabolic profile. The control group consisted of age- and BMI-matched 80 eumenorrheic women with no clinical or biochemical hyperandrogenism. Our results showed that women with PCOS had significantly higher serum BPA concentrations than healthy controls (geometric mean and [95% CI]: 0. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.09.006DOI Listing
December 2018
7 Reads

Smoking alters hydroxyprostaglandin dehydrogenase expression in fetal membranes.

Reprod Toxicol 2018 Dec 21;82:18-24. Epub 2018 Sep 21.

Department of Obstetrics and Gynecology, Level D, St Michael's Hospital, Southwell Street, Bristol, BS2 8EG, UK; University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY, UK. Electronic address:

Introduction: The way in which tobacco smoking increases the risk of preterm labor remains uncertain. Altered prostaglandin metabolism is one potential mechanism.

Methods: Proteins in fetal membrane samples (amniochoriodecidua) from 20 women were relatively quantified using Tandem Mass Tagging nano-liquid chromatography mass spectrometry. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.09.004DOI Listing
December 2018
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Effect of endocrine disruptors on the ratio of X and Y chromosome-bearing live spermatozoa.

Reprod Toxicol 2018 Dec 13;82:10-17. Epub 2018 Sep 13.

Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi-Do 17546, Republic of Korea. Electronic address:

Although equal numbers of X and Y spermatozoa are produced during spermatogenesis, the sex chromosome ratio in ejaculated spermatozoa can be altered by exposure to endocrine-disrupting chemicals (EDCs), which can be reflected by altered sex ratios at birth. Here, we hypothesized EDCs affect sperm functions and viability of X and Y chromosome-bearing human spermatozoa. After exposure to genistein (Gen), bisphenol A (BPA), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), dibromochloropropane (DBCP), and diazinon (Diaz), we evaluated motility, viability, capacitation, and differential viability of X and Y spermatozoa. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.09.002DOI Listing
December 2018
14 Reads
3.230 Impact Factor

Phthalate exposure and odds of bacterial vaginosis among U.S. reproductive-aged women, NHANES 2001-2004.

Reprod Toxicol 2018 Dec 9;82:1-9. Epub 2018 Sep 9.

Department of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC, USA. Electronic address:

Endocrine-disrupting chemicals, such as phthalates, are an unexamined potential risk factor for bacterial vaginosis (BV) and warrant investigation because hormones affect BV. We examined the association between phthalate exposure and BV in the National Health and Nutrition Examination Survey, 2001-2004. BV outcomes were defined as intermediate (Nugent score of 4-6) and positive (7-10). Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310056PMC
December 2018
4 Reads