1,955 results match your criteria Reproductive Sciences[Journal]


Progesterone Receptor B ( PGR-B) Is Partially Methylated in Eutopic Endometrium From Infertile Women With Endometriosis.

Reprod Sci 2019 Feb 19:1933719119828078. Epub 2019 Feb 19.

1 Human Reproduction Division, Department of Obstetrics and Gynecology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil.

Endometriosis is frequently related to infertility and little is known about the mechanisms underlying this association. Some studies point to an endometrial factor involved in this condition, which could compromise embryo implantation. Progesterone plays crucial role in endometrial receptivity by acting through progesterone receptor ( PGR) isoforms PR-A and PR-B whose expression is epigenetically regulated by DNA methylation, in a specific promoter region for each isoform. Read More

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http://dx.doi.org/10.1177/1933719119828078DOI Listing
February 2019

Sphingosine 1 Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells.

Reprod Sci 2019 Feb 19:1933719119828112. Epub 2019 Feb 19.

1 Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.

Objects:: There is growing evidence that sphingosine 1-phosphate (S1P) is involved in inflammatory diseases. As endometriosis is known as an inflammatory disease, we investigated the role of S1P system in the development of endometriosis.

Methods:: The expression of sphingosine kinase (SphK) 1 in endometriosis lesions was examined by immunohistochemistry. Read More

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http://dx.doi.org/10.1177/1933719119828112DOI Listing
February 2019

Rapamycin Corrects T Regulatory Cell Depletion and Improves Embryo Implantation and Live Birth Rates in a Murine Model.

Reprod Sci 2019 Feb 19:1933719119828110. Epub 2019 Feb 19.

1 National Institute of Child Health and Human Development, Bethesda, MD, USA.

There are few treatments for patients with recurrent pregnancy loss (RPL) or recurrent implantation failure (RIF). Women with RPL and unexplained infertility have lower T regulatory cell (T) expression when compared to fertile controls. A murine model has been developed with depletion of regulatory T cells (DEREG) after administration of diphtheria toxin (DT), resulting in smaller litter sizes, secondary to embryo implantation failure. Read More

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http://dx.doi.org/10.1177/1933719119828110DOI Listing
February 2019

Downregulation of MicroRNA-125a in Placenta Accreta Spectrum Disorders Contributes Antiapoptosis of Implantation Site Intermediate Trophoblasts by Targeting MCL1.

Reprod Sci 2019 Feb 19:1933719119828040. Epub 2019 Feb 19.

1 Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, People's Republic of China.

The typical hallmark of placenta accreta spectrum (PAS) disorders is increased implantation site intermediate trophoblast (ISIT) cell numbers. However, the extent of trophoblast proliferation and apoptosis have not been found to differ from those of normal placentation. MicroRNA-125a (miR-125a) induces apoptosis in colon cancer cell by targeting myeloid cell leukemia-1 gene ( MCL1). Read More

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http://dx.doi.org/10.1177/1933719119828040DOI Listing
February 2019

Gestational and Hormonal Effects on Magnesium Sulfate's Ability to Inhibit Mouse Uterine Contractility.

Reprod Sci 2019 Feb 17:1933719119828089. Epub 2019 Feb 17.

1 Department of Cellular and Molecular Physiology, University Department, Harris-Wellbeing Preterm Birth Research Centre, The Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

Magnesium sulfate is used as a tocolytic, but clinical efficacy has been seriously questioned. Our objective was to use controlled ex vivo conditions and known pregnancy stages, to investigate how 2 key factors, hormones and gestation, affect magnesium's tocolytic ability. We hypothesized that these factors could underlie the varying clinical findings around magnesium's efficacy. Read More

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http://dx.doi.org/10.1177/1933719119828089DOI Listing
February 2019
1 Read

Reduction in FSH Throughout the Menstrual Cycle After Omega-3 Fatty Acid Supplementation in Young Normal Weight but not Obese Women.

Reprod Sci 2019 Feb 17:1933719119828099. Epub 2019 Feb 17.

1 Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, USA.

Dietary fish oil restores ovarian function in subfertile rats, which is thought to be associated with decreased transcription of follicle-stimulating hormone (FSH) β-subunit. We have previously demonstrated a reduction in early follicular serum FSH levels in normal weight but not obese women after treatment with omega-3 polyunsaturated fatty acids (PUFA). Herein, we report the effect of supplementation with omega-3 PUFA on urinary reproductive hormones across the whole menstrual cycle. Read More

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http://dx.doi.org/10.1177/1933719119828099DOI Listing
February 2019

Lipoxin A Suppresses IL-1β-Induced Cyclooxygenase-2 Expression Through Inhibition of p38 MAPK Activation in Endometriosis.

Reprod Sci 2019 Feb 17:1933719119828115. Epub 2019 Feb 17.

1 Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, Xiamen, People's Republic of China.

Endometriosis is an inflammation-dependent gynecologic disorder. Increased cyclooxygenase-2 (COX-2) expression plays an important role in the development and progression of endometriosis. Lipoxin A (LXA) is an endogenous anti-inflammation lipid and showed inhibitory effects on the development of endometriosis; however, the mechanism remains unclear. Read More

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http://dx.doi.org/10.1177/1933719119828115DOI Listing
February 2019

Ovarian Reserve Reduction With Surgery Is Not Correlated With the Amount of Ovarian Tissue Inadvertently Excised at Laparoscopic Surgery for Endometriomas.

Reprod Sci 2019 Feb 14:1933719119828055. Epub 2019 Feb 14.

1 Department of Obstetrics and Gynecology, "Sapienza" University of Rome, Rome, Italy.

The aim of the present study was to evaluate the effect of laparoscopic cystectomy on ovarian reserve by means of anti-Müllerian hormone (AMH) serial measurements and to compare AMH values with the number of inadvertently removed follicles in histological specimens. Fifty-two women were enrolled: 34 patients with endometriomas (group 1) and 18 patients with other benign ovarian cysts (group 2). All patients underwent laparoscopic cystectomy performed by a single experienced surgeon. Read More

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http://dx.doi.org/10.1177/1933719119828055DOI Listing
February 2019
1 Read

PAX8: A Highly Sensitive Marker for the Glands in Extragenital Endometriosis.

Reprod Sci 2019 Feb 14:1933719119828095. Epub 2019 Feb 14.

1 Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan.

In cases of extragenital endometriosis or microscopic endometriosis lesions, pathological diagnosis can be challenging because endometriotic stroma and glands represent only a minor component of fibrotic endometriotic lesions. For better accuracy of diagnosis, the development of a sensitive and specific epithelial marker is beneficial. Previous studies showed that PAX8 is a highly sensitive and specific marker for primary and metastatic Mullerian epithelial tumors. Read More

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http://dx.doi.org/10.1177/1933719119828095DOI Listing
February 2019
1 Read

Perioperative Intervention by β-Blockade and NF-κB Suppression Reduces the Recurrence Risk of Endometriosis in Mice Due to Incomplete Excision.

Reprod Sci 2019 Feb 14:1933719119828066. Epub 2019 Feb 14.

1 Shanghai OB/GYN Hospital, Fudan University, Shanghai, China.

Despite the demonstrated efficacy of surgical treatment of endometriosis, recurrence after surgery still remains a formidable challenge. Surgery, especially when performed repeatedly, decreases ovarian reserve. Clearly, control of recurrence is an unmet medical need. Read More

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http://dx.doi.org/10.1177/1933719119828066DOI Listing
February 2019

Expression, Regulation, and Function of the Calmodulin Accessory Protein PCP4/PEP-19 in Myometrium.

Reprod Sci 2019 Feb 11:1933719119828072. Epub 2019 Feb 11.

1 Department of Obstetrics and Gynecology, Division of Research, University of Kansas School of Medicine, Kansas City, KS, USA.

Objective:: Calmodulin (CaM) plays a key role in the orchestration of Ca signaling events, and its regulation is considered an important component of cellular homeostasis. The control of uterine smooth muscle function is largely dependent on the regulation of Ca and CaM signaling. The objective of this study was to investigate the expression, function, and regulation of CaM regulatory proteins in myometrium during pregnancy. Read More

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http://dx.doi.org/10.1177/1933719119828072DOI Listing
February 2019
3 Reads

Fetal Growth Restriction Is Associated With Decreased Number of Ovarian Follicles and Impaired Follicle Growth in Young Adult Guinea Pig Offspring.

Reprod Sci 2019 Feb 11:1933719119828041. Epub 2019 Feb 11.

1 Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.

Background:: The mechanisms mediating the impacts of fetal growth restriction (FGR) on follicular development are commonly studied in mouse/rat models, where ovarian development occurs largely during the early postnatal period. These models have shown that FGR is associated with premature follicle loss, early pubertal onset, and accelerated ovarian aging. Whether the same occurs in precocious species is unknown. Read More

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http://dx.doi.org/10.1177/1933719119828041DOI Listing
February 2019

Antibody Microarray Analysis of Plasma Proteins for the Prediction of Histologic Chorioamnionitis in Women With Preterm Premature Rupture of Membranes.

Reprod Sci 2019 Feb 6:1933719119828043. Epub 2019 Feb 6.

2 Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, South Korea.

We aimed to identify maternal blood biomarkers predictive of histologic chorioamnionitis (HCA) in the plasma of women with preterm premature rupture of membranes (PPROM) and to determine whether the combination of these biomarkers with conventional clinical variables can improve the prediction of HCA. This retrospective cohort study included 82 consecutive women with PPROM (23-34 gestational weeks) who delivered within 96 hours of blood sampling. A membrane-based human antibody microarray was used to analyze the plasma proteome. Read More

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http://dx.doi.org/10.1177/1933719119828043DOI Listing
February 2019

Evaluation of Sperm DNA Fragmentation via Halosperm Technique and TUNEL Assay Before and After Cryopreservation.

Reprod Sci 2019 Feb 4:1933719119828096. Epub 2019 Feb 4.

5 Department of Obstetrics and Gynecology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Acibadem Altunizade Hospital, Unit of ART, Istanbul, Turkey.

Aim:: Human sperm DNA fragmentation is one of the factors suggested for male infertility. The ratio of sperm DNA damage in semen may adversely affect both the fertilization rate and the embryo development of in vitro fertilization/ intracytoplasmic sperm injection cycles. Sperm cryopreservation both increases the success rates in assisted reproductive techniques (ARTs) and contributes to the preservation of fertility before testis surgery, chemotherapy, and radiotherapy. Read More

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http://journals.sagepub.com/doi/10.1177/1933719119828096
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http://dx.doi.org/10.1177/1933719119828096DOI Listing
February 2019
2 Reads

Not Having Been Breastfed May Protect Chinese Women From Developing Deep Infiltrating Endometriosis: Results From Subgroup Analyses of the FEELING Study.

Reprod Sci 2019 Jan 22:1933719118820469. Epub 2019 Jan 22.

1 Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Background:: This study aimed to investigate potential factors, especially early-life exposures, associated with endometrioma (OMA) and/or deep infiltrating endometriosis (DIE) in Chinese women.

Methods:: This is a subgroup analyses of the FEELING study, which was a case-control study that investigated the clinical, lifestyle, and environmental factors associated with OMA and/or DIE in China, Russia, and France. In this subgroup analysis, the data for the Chinese participants were further analyzed using logistic regression model. Read More

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http://dx.doi.org/10.1177/1933719118820469DOI Listing
January 2019
1 Read

Cervix Stromal Cells and the Progesterone Receptor A Isoform Mediate Effects of Progesterone for Prepartum Remodeling.

Reprod Sci 2019 Jan 17:1933719118820462. Epub 2019 Jan 17.

1 Longo Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, USA.

The prepartum transition from a soft to ripening cervix is an inflammatory process that occurs well before birth when systemic progesterone is near peak concentration. This 2-part study first determined that stromal fibroblasts but not macrophages in the cervix have progesterone receptors (PRs). Neither the number of PR cells in cervix sections nor the relative abundance or ratio of nuclear PR isoforms (PR-A/PR-B) were diminished in mice between day 15 of pregnancy and term. Read More

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http://dx.doi.org/10.1177/1933719118820462DOI Listing
January 2019
1 Read

Regulation of CX3CL1 Expression in Human First-Trimester Decidual Cells: Implications for Preeclampsia.

Reprod Sci 2019 Jan 3:1933719118815592. Epub 2019 Jan 3.

2 Department of Obstetrics and Gynecology, University of South Florida, Tampa, FL, USA.

C-X3-C motif ligand 1 (CX3CL1) mediates migration, survival, and adhesion of natural killer (NK) cells, monocytes, and T-cells to endothelial/epithelial cells. Aberrant numbers and/or activation of these decidual immune cells elicit preeclampsia development. Decidual macrophages and NK cells are critical for implantation, while macrophage-derived tumor necrosis factor-α (TNF-α), interleukin-1 β (IL-1β), and NK cell-derived interferon-γ (IFN-γ) are associated with preeclampsia development. Read More

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http://dx.doi.org/10.1177/1933719118815592DOI Listing
January 2019
8 Reads

Metformin Regulates Key MicroRNAs to Improve Endometrial Receptivity Through Increasing Implantation Marker Gene Expression in Patients with PCOS Undergoing IVF/ICSI.

Reprod Sci 2019 Jan 1:1933719118820466. Epub 2019 Jan 1.

1 Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.

To some extent, the use of metformin may improve endometrial receptivity and pregnancy outcomes of women with polycystic ovarian syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection. However, the mechanism is not well-known. The endometrium of metformin-treated group (metformin-treated patients with PCOS) and the control group (non-metformin-treated patients with PCOS) were analyzed for the expression of homeobox A10 (HOXA10) and integrin beta-3 (ITGB3) and differential micro RNA (miRNA) expression profiles. Read More

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http://dx.doi.org/10.1177/1933719118820466DOI Listing
January 2019
7 Reads

Increased Expression of KISS1 and KISS1 Receptor in Human Granulosa Lutein Cells-Potential Pathogenesis of Polycystic Ovary Syndrome.

Reprod Sci 2018 Dec 30:1933719118818899. Epub 2018 Dec 30.

1 Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Kisspeptins are a family of neuropeptides that are essential for fertility. Recent experimental data suggest a putative role of kisspeptin signaling in the direct control of ovarian function. To explore the expression of KISS1 and KISS1 receptor (KISS1R) in human granulosa lutein cells and the potential role of KISS1/KISS1R system in the pathogenesis of polycystic ovary syndrome (PCOS), we measured the concentration of KISS1 in follicular fluid, the expression of KISS1 and KISS1R in granulosa lutein cells, and the circulating hormones. Read More

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http://dx.doi.org/10.1177/1933719118818899DOI Listing
December 2018
5 Reads

Decreased Ang-(1-7) and Downregulated Intrarenal RAS May Contribute to the Direct Podocyte Injury With Proteinuria in Preeclampsia.

Reprod Sci 2018 Dec 30:1933719118813200. Epub 2018 Dec 30.

1 Division of Nephrology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, People's Republic of China.

The mechanisms of proteinuria development in preeclampsia (PE) are still enigmatic. Renin-angiotensin system (RAS) components may play a role. Maternal serum and urinary concentrations of angiotensin-(1-7) [Ang-(1-7)], angiotensin II (Ang II), and angiotensinogen in women with PE (n = 14), gestational hypertension (n = 14), and normal pregnancy were quantified. Read More

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http://dx.doi.org/10.1177/1933719118813200DOI Listing
December 2018
2 Reads

Regulation of Embryonic Signal on Talin1 in Mouse Endometrium.

Reprod Sci 2018 Dec 20:1933719118815584. Epub 2018 Dec 20.

1 Department of Reproductive Center, First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Embryonic signals can affect the spatiotemporal-specific expression of the uterus to establish a successful pregnancy. Our previous study has found that talin1 underwent dynamic changes in the mouse endometrium during peri-implantation period. However, whether talin1 is affected by the embryo signals is not clear. Read More

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http://dx.doi.org/10.1177/1933719118815584DOI Listing
December 2018
1 Read

Cell-Free DNA Release by Mouse Fetal Membranes.

Reprod Sci 2018 Dec 20:1933719118817659. Epub 2018 Dec 20.

1 Division of Maternal-Fetal Medicine and the Vincent Center for Reproductive Biology, Department of Obstetrics & Gynecology, Massachusetts General Hospital, Boston, MA, USA.

Introduction:: Cell-free "fetal" DNA is released from the placenta. Because the fetal membranes also arise from the trophectoderm layer of the blastocyst, these studies sought to test the hypothesis that the membranes also release cell-free DNA (cfDNA).

Methods:: Fetal membranes were harvested from pregnant CD-1 mice and cultured in 12-well plates containing media alone or with staurosporine and thapsigargin (apoptosis stimulators), Q-VD-OPh (caspase inhibitor), Trolox (vitamin E analog), and lipopolysaccharide and tumor necrosis factor α (TNFα; inflammatory mediators). Read More

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http://dx.doi.org/10.1177/1933719118817659DOI Listing
December 2018
12 Reads

Low-Dose Aspirin May Prevent Trophoblast Dysfunction in Women With Chlamydia Pneumoniae Infection.

Reprod Sci 2018 Dec 20:1933719118820468. Epub 2018 Dec 20.

2 Maternal and Child Health Research Program, University of Pennsylvania, Philadelphia, PA, USA.

Objective:: Previously, we demonstrated that live Chlamydia pneumoniae (Cp) impaired extravillous trophoblast (EVT) viability and invasion and that Cp DNA was detected in placentas from cases with preeclampsia. We sought to elucidate whether (1) inactive forms of Cp also affect EVT function; (2) potential therapeutic interventions protect against the effects of Cp; and (3) anti-Cp antibodies are associated with preeclampsia.

Methods:: Human first-trimester EVTs were infected with ultraviolet light-inactivated Cp. Read More

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http://dx.doi.org/10.1177/1933719118820468DOI Listing
December 2018
11 Reads

A Comparison of Pregnancy Outcomes in Patients Undergoing Donor Egg Single Embryo Transfers With and Without Preimplantation Genetic Testing.

Reprod Sci 2018 Dec 20:1933719118820474. Epub 2018 Dec 20.

1 New York University Fertility Center, New York, NY, USA.

Two of the many milestone developments in the field of assisted reproduction have been oocyte donation and preimplantation genetic testing for aneuploidy (PGT-A). Because it has been demonstrated that even young women produce a meaningful proportion of aneuploid embryos, screening out such abnormalities could potentially increase the efficacy of donor egg (DE) cycles. In this retrospective cohort study, we investigated the effect of PGT-A on DE cycle outcomes, including implantation rate (IR), spontaneous abortion rate (SABR), and ongoing pregnancy/live birth rate. Read More

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http://dx.doi.org/10.1177/1933719118820474DOI Listing
December 2018
5 Reads

Ulipristal Acetate Mediates Decreased Proteoglycan Expression Through Regulation of Nuclear Factor of Activated T-Cells (NFAT5).

Reprod Sci 2018 Dec 19:1933719118816836. Epub 2018 Dec 19.

1 Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Nuclear factor of activated T-cells (NFAT5) is a tissue specific, osmoadaptive transcription factor essential for the control of hydration homeostasis in mammalian cells. Nuclear factor of activated T-cells regulates osmolyte transporters aldo-keto reductase family 1 member B1 (AKR1B1) and solute carrier family 5 member 3 (SLC5A3) to maintain fluid equilibrium in cells. The osmotic potential of the extracellular matrix of leiomyomas is attributed to the role of proteoglycans. Read More

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http://dx.doi.org/10.1177/1933719118816836DOI Listing
December 2018
1 Read
2.230 Impact Factor

Scutellarin Suppresses Platelet Aggregation and Stalls Lesional Progression in Mouse With Induced Endometriosis.

Reprod Sci 2018 Dec 17:1933719118817661. Epub 2018 Dec 17.

1 Shanghai OB/GYN Hospital, Fudan University, Shanghai, China.

Platelets play an important role in the development of endometriosis. Scutellarin is a flavonoid isolated from a medicinal herb traditionally used as a potent antiplatelet agent. In this study, we sought to evaluate its potential therapeutic effect, if any, in mice with induced endometriosis. Read More

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http://dx.doi.org/10.1177/1933719118817661DOI Listing
December 2018
2 Reads

Mate Choice and the Persistence of Maternal Mortality.

Reprod Sci 2018 Dec 13:1933719118812730. Epub 2018 Dec 13.

1 Department of Biology, McMaster University, Hamilton, Canada. Santosh Jagadeeshan is now with the Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada.

Maternal mortality remains one of the leading causes of death in women of reproductive age in developing countries, and a major concern in some developed countries. It is puzzling why such a condition has not been reduced in frequency, if not eliminated, in the course of evolution. Maternal mortality is a complex phenomenon caused by several physiological and physical factors. Read More

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http://dx.doi.org/10.1177/1933719118812730DOI Listing
December 2018
1 Read

Resumption of Ovarian Function After Ovarian Biopsy/Scratch in Patients With Premature Ovarian Insufficiency.

Reprod Sci 2018 Dec 12:1933719118818906. Epub 2018 Dec 12.

1 Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China.

To evaluate the effect of ovarian biopsy and scratch on the resumption of ovarian function in women with premature ovarian insufficiency (POI), the follicle development and pregnancy outcome were retrospectively analyzed in women with POI after ovarian biopsy/scratch. Eighty patients with POI with secondary amenorrhea were accepted the laparoscopic surgery, and then hormone replacement treatment for 6 months was applied and in vitro fertilization and embryo transfer was suggested. No significant difference in clinical characteristics was observed before and after ovarian biopsy/scratch ( P > . Read More

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http://dx.doi.org/10.1177/1933719118818906DOI Listing
December 2018
2 Reads

Cytokine Changes in Maternal Peripheral Blood Correlate With Time-to-Delivery in Pregnancies Complicated by Premature Prelabor Rupture of the Membranes.

Reprod Sci 2018 Dec 12:1933719118815590. Epub 2018 Dec 12.

2 Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Toronto, Ontario, Canada.

Premature prelabor rupture of the membranes (PPROM) causes one-third of preterm births worldwide and is most likely caused by subclinical intrauterine infection and/or inflammation. We proposed that women with systemic inflammation at the time of PPROM would have shorter latency. Peripheral blood samples were collected from 20 singleton pregnant women with PPROM between 23 ± 1 and 33 ± 6 weeks. Read More

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http://dx.doi.org/10.1177/1933719118815590DOI Listing
December 2018
1 Read

Maternal Oxidative Stress, Placental Morphometry, and Fetal Growth in Diabetic Rats Exposed to Cigarette Smoke.

Reprod Sci 2018 Dec 6:1933719118815589. Epub 2018 Dec 6.

1 Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu, São Paulo, Brazil.

The diabetic syndrome affects pregnancy, contributing to placental functional and structural disruptions and impaired fetal development, with many reports indicating tobacco-associated morbidity and perinatal mortality. In our study, an experimental rat model of diabetes and cigarette smoke exposure in pregnant rats was used to determine the impact of the combination of diabetes and exposure to cigarette smoke during pregnancy on maternal oxidative stress biomarkers and placental and fetal development. Diabetes was induced by streptozotocin, and dams were exposed to cigarette smoke by mainstream smoke generated by a mechanical smoking device and delivered into a chamber. Read More

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http://dx.doi.org/10.1177/1933719118815589DOI Listing
December 2018
2 Reads

DNA Methylation Inhibitor 5-Aza-2'-Deoxycytidine Modulates Endometrial Receptivity Through Upregulating HOXA10 Expression.

Reprod Sci 2018 Dec 6:1933719118815575. Epub 2018 Dec 6.

2 Department of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.

Endometrial receptivity is a critical factor for embryo implantation. A decrease in endometrial homeobox A10 (HOXA10) expression is associated with hypermethylation of its promoter and lower endometrial receptivity in animals and humans. 5-Aza-2'-deoxycytidine (AZA) is a DNA methyltransferase inhibitor. Read More

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http://dx.doi.org/10.1177/1933719118815575DOI Listing
December 2018
3 Reads
2.230 Impact Factor

Methylseleninic Acid Suppresses Breast Cancer Growth via the JAK2/STAT3 Pathway.

Reprod Sci 2018 Dec 9:1933719118815582. Epub 2018 Dec 9.

1 Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China.

Previous studies show that methylseleninic acid (MSA), which is the most common selenium derivative used as a drug in humans, exerts specific cytotoxic effects in several cancer cell types. However, the complex mechanism of these effects has not been fully elucidated. Here, we demonstrate by Cell Counting Kit-8 in mouse breast cancer cell line 4T1 that MSA inhibits cell viability in a concentration-dependent (5, 10, 20 μmol/L) and time-dependent (6, 12, 24 hours) manner. Read More

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http://journals.sagepub.com/doi/10.1177/1933719118815582
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http://dx.doi.org/10.1177/1933719118815582DOI Listing
December 2018
12 Reads

Comparative Effects of Estrogen and Phytoestrogen, Genistein on Testicular Activities of Streptozotocin-Induced Type 2 Diabetic Mice.

Reprod Sci 2018 Dec 5:1933719118815576. Epub 2018 Dec 5.

3 Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

The aim of this study was to compare the effect of synthetic estrogen (E2) with a phytoestrogen and genistein in ameliorating type 2 diabetes mellitus (T2D)-mediated testicular dysfunction in mice. The streptozotocin (STZ)-induced type 2 diabetic mice were treated exogenously with either E2 or genistein for 2 durations and compared their effects on testicular activities, serum glucose, and insulin level. Type 2 diabetic mice treated with E2 for only short term (14 days) improved regressive changes in the testicular histology by increasing testosterone synthesis and improving insulin sensitivity, whereas those treated for longer duration (28 days) failed to improve testicular dysfunctions. Read More

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http://dx.doi.org/10.1177/1933719118815576DOI Listing
December 2018
2 Reads

The Disease Phenotype of Adenomyosis-Affected Women Correlates With Specific Serum Cytokine Profiles.

Reprod Sci 2018 Dec 5:1933719118816852. Epub 2018 Dec 5.

1 Department of Gynaecology Obstetrics II and Reproductive Medicine, Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Universitaire Paris Centre, Centre Hospitalier Universitaire (CHU) Cochin, Paris, France.

Background:: Adenomyosis (ADE) is an enigmatic uterine disorder. Several types have been previously described: diffuse adenomyosis (DIF-ADE), focal adenomyosis (FOC-ADE), and association of focal and diffuse lesions (FOC/DIF-ADE). Abnormal immune phenomena have been described that may provide an understanding of the pathophysiology of adenomyosis. Read More

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http://dx.doi.org/10.1177/1933719118816852DOI Listing
December 2018
20 Reads

Endometrial but not Ovarian Response is Associated With Clinical Outcomes and can be Improved by Prolonged Pituitary Downregulation in Patients With Thin and Medium Endometrium.

Reprod Sci 2018 Dec 3:1933719118816835. Epub 2018 Dec 3.

1 Reproductive Medicine Centre, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan, China.

The aim of this study is to investigate the effect of ovarian and endometrial response on live birth rates (LBRs) in young normal and high responders and prolonged pituitary downregulation on endometrial receptivity and clinical outcomes in patients with different endometrial thickness. Between January 2013 and December 2017, 9511 patients underwent first in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles with age ≤35 years, follicle stimulating hormone < 10 IU/l, and ≥4 retrieved oocytes were conducted. The estradiol (E) levels on the human chorionic gonadotropin (HCG) day were classified into 4 groups: group 1 (<3000 pg/mL); group 2 (3000-5000 pg/mL); group 3 (5000-7000 pg/mL), and group 4 (≥7000 pg/mL). Read More

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http://dx.doi.org/10.1177/1933719118816835DOI Listing
December 2018
3 Reads

1,25 Dihydroxyvitamin D3 Enhances the Antifibroid Effects of Ulipristal Acetate in Human Uterine Fibroids.

Reprod Sci 2018 Dec 4:1933719118812720. Epub 2018 Dec 4.

1 Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, IL, USA.

Background:: Both European and American trials showed superior effect of ulipristal acetate (UPA) to placebo. However, the latter, which included black patients with known higher vitaminD3 deficiency risk, showed lower rate of amenorrhea responders and insignificant uterine fibroid (UF) size reduction. Our objective is to investigate whether adding vitamin D to UPA can enhance UPA potency on UF phenotype in vitro. Read More

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http://journals.sagepub.com/doi/10.1177/1933719118812720
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http://dx.doi.org/10.1177/1933719118812720DOI Listing
December 2018
9 Reads
2.230 Impact Factor

Impaired Localization of Claudin-11 in Endometriotic Epithelial Cells Compared to Endometrial Cells.

Reprod Sci 2018 Dec 4:1933719118811643. Epub 2018 Dec 4.

1 Department of Gynecology and Obstetrics, University of Giessen, Giessen, Germany.

Claudins are the major components of tight junctions and are often deregulated in human cancer, permitting escape of cancer cells along with the acquisition of invasive properties. Similarly, endometrial cells also show invasive capabilities; however, the role of tight junctions in endometriosis has only rarely been examined. In this study, we analyzed the protein expression and localization of claudin-7 and claudin-11 in human eutopic and ectopic endometrium and endometrial cell lines. Read More

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http://dx.doi.org/10.1177/1933719118811643DOI Listing
December 2018
2 Reads

Necessity to Evaluate Epigenetic Quality of the Sperm for Assisted Reproductive Technology.

Reprod Sci 2019 Mar 29;26(3):315-322. Epub 2018 Nov 29.

3 The Center for Reproductive Medicine of Affiliated Hospital of Hebei University, Baoding, China.

Spermatogenesis is a highly complex process involving dynamic erasure and establishment of epigenetic modifications. Abnormal epigenetic marks have been shown to result in altered spermatogenesis and even cause male infertility. Assisted reproductive technology, with directly dealing and selecting the morphology qualified sperm, can be applied to treat male infertility, which may carry significant risks of passing on epigenetic defects to next generations. Read More

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http://dx.doi.org/10.1177/1933719118808907DOI Listing
March 2019
13 Reads

Granulocyte Colony-Stimulating Factor Prevents Ischemia/Reperfusion-Induced Ovarian Injury in Rats: Evaluation of Histological and Biochemical Parameters.

Reprod Sci 2018 Nov 29:1933719118816839. Epub 2018 Nov 29.

2 Department of Physiology, Istanbul Bilim University School of Medicine, Istanbul, Turkey.

Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein commonly used in the field of medicine to treat neutropenia. Granulocyte colony-stimulating factor has also crucial roles in ameliorating the ischemia/reperfusion (I/R) injury in particular tissues. In this study, we aimed to investigate the protective effect of G-CSF on ovarian damage in experimental ovarian I/R injury. Read More

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http://dx.doi.org/10.1177/1933719118816839DOI Listing
November 2018
4 Reads

Performance of Risk Assessment Models for Peripartum Thromboprophylaxis.

Reprod Sci 2018 Nov 28:1933719118813197. Epub 2018 Nov 28.

2 Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, TX, USA.

Objective:: There is no consensus on which risk stratification approach to use for thromboprophylaxis in pregnancy, and most available risk assessment models (RAMs) for venous thromboembolism (VTE) events have not been validated in pregnancy. Our objective was to compare the performance of some of the most commonly used VTEs RAMs in our patient population in the peripartum period.

Study Design:: This is a retrospective cohort of women who delivered at our institution in 2015 and 2016. Read More

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http://dx.doi.org/10.1177/1933719118813197DOI Listing
November 2018
12 Reads

Telomere Homeostasis and Senescence Markers Are Differently Expressed in Placentas From Pregnancies With Early- Versus Late-Onset Preeclampsia.

Reprod Sci 2018 Nov 25:1933719118811644. Epub 2018 Nov 25.

1 Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel.

Background:: Early-onset preeclampsia (EOPE; <34 weeks' gestation) usually has more severe morbidity for the mother and fetus compared to late-onset preeclampsia (LOPE). Telomere homeostasis is disrupted in preeclampsia (PE) and senescence markers are increased. The pathophysiologic differences between early and LOPE are not fully unraveled yet. Read More

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http://dx.doi.org/10.1177/1933719118811644DOI Listing
November 2018
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Aspirin in Preeclampsia and Its Molecular Intermediators.

Reprod Sci 2018 Dec;25(12):1605-1606

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http://dx.doi.org/10.1177/1933719118810611DOI Listing
December 2018
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Overexpression of Collapsin Response Mediator Protein 1 Inhibits Human Trophoblast Cells Proliferation, Migration, and Invasion.

Reprod Sci 2018 Nov 22:1933719118799214. Epub 2018 Nov 22.

1 Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, Liaoning Province, China.

Collapsin response mediator protein 1 (CRMP-1) is widely expressed in the nervous system and has tumor suppressive effects. Our previous studies have demonstrated that CRMP-1 was expressed in the trophoblasts of the whole stage of pregnancy with significantly increasing expression in the placenta of early-onset preeclampsia. Preeclampsia, especially early onset, is strongly associated with the dysfunction of trophoblast including proliferation, apoptosis, migration, and invasion. Read More

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http://dx.doi.org/10.1177/1933719118799214DOI Listing
November 2018
5 Reads

Metformin Promotes Regeneration of the Injured Endometrium Via Inhibition of Endoplasmic Reticulum Stress-Induced Apoptosis.

Reprod Sci 2018 Nov 22:1933719118804424. Epub 2018 Nov 22.

1 Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Intrauterine adhesion (IUA) is now recognized as one of the most common diseases in reproductive-age women. Metformin, a well-known frontline oral antidiabetic drug, has been found effective in numerous different diseases. The aim of this study was to determine the effect of metformin on reducing adhesions in an animal model of IUA. Read More

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http://dx.doi.org/10.1177/1933719118804424DOI Listing
November 2018
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The Absence of TLR4 Prevents Fetal Brain Injury in the Setting of Intrauterine Inflammation.

Reprod Sci 2018 Nov 21:1933719118805859. Epub 2018 Nov 21.

1 Department of Obstetrics and Gynecology, Maternal and Child Health Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background:: Exposure to intrauterine inflammation during pregnancy is linked to brain injury and neurobehavioral disorders in affected children. Innate immunity, specifically Toll-like receptor (TLR) signaling pathways are present throughout the reproductive tract as well as in the placenta, fetal membranes, and fetus. The TLR pathways are mechanistically involved in host responses to foreign pathogens and may lead to brain injury associated with prenatal inflammation. Read More

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http://dx.doi.org/10.1177/1933719118805859DOI Listing
November 2018
9 Reads

The Impact of Immunosuppressive Drugs on Human Placental Explants.

Reprod Sci 2018 Nov 20:1933719118812739. Epub 2018 Nov 20.

1 Department of Cellular and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

The use of immunosuppressive drugs guarantees the vitality of the graft and allows gestation in spite of intercurrences such as prematurity and intrauterine growth restriction. However, little is known about the direct effects of immunosuppressive drugs on placental cells. We investigated the effects of immunosuppressive drugs in the chorionic villous explants from human term placentas of healthy gestations. Read More

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http://dx.doi.org/10.1177/1933719118812739DOI Listing
November 2018
2 Reads

The Deferred Embryo Transfer Strategy Seems Not to be a Good Option After Repeated IVF/ICSI Cycle Failures.

Reprod Sci 2018 Nov 20:1933719118811648. Epub 2018 Nov 20.

1 Faculté de Médecine, Département de gynécologie, obstétrique II et médecine de la reproduction, Assistance Publique-Hôpitaux de Paris (AP-HP), Centre Hospitalier Universitaire (CHU) Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

Objective:: The aim of this study was to assess whether a deferred frozen-thawed embryo transfer (Def-ET) offers any benefits compared to a fresh ET strategy in women who have had 2 or more consecutive in vitro fertilization (IVF)/intracytoplasmic injection (ICSI) cycle failures.

Design:: An observational cohort study in a tertiary referral care center including 416 cycles from women with a previous history of 2 or more consecutive IVF/ICSI failures cycles. Both Def-ET and fresh ET strategies were compared using univariate and multivariate logistic regression models. Read More

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http://dx.doi.org/10.1177/1933719118811648DOI Listing
November 2018
7 Reads

Role of RFRP-3 in the Regulation of Kiss-1 Gene Expression in the AVPV Hypothalamic Cell Model mHypoA-50.

Reprod Sci 2018 Nov 20:1933719118813456. Epub 2018 Nov 20.

1 Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan.

Kisspeptin, encoded by the Kiss-1 gene, plays a crucial role in reproductive function by governing the hypothalamic-pituitary-gonadal axis. The recently established Kiss-1-expressing cell model mHypoA-50 displays characteristics of neuronal cells of the anteroventral periventricular (AVPV) region of the mouse hypothalamus. Because Kiss-1 gene expression in these cells is upregulated by estradiol (E2), mHypoA-50 cells are regarded as a valuable model for the study of Kiss-1-expressing neurons in the AVPV region. Read More

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http://dx.doi.org/10.1177/1933719118813456DOI Listing
November 2018
17 Reads

Bone Marrow Mesenchymal Stem Cells (BMSCs) Restore Functional Endometrium in the Rat Model for Severe Asherman Syndrome.

Reprod Sci 2019 Mar 20;26(3):436-444. Epub 2018 Nov 20.

5 Institute of Clinical Medicine, Jinan University, Guangzhou, China.

Objective:: To investigate the feasibility to restore functional endometrium using bone marrow mesenchymal stem cells (BMSCs) in the Sprague Dawley (SD["SD" has been defined as both "Sprague Dawley" and "standard deviation." Please clarify which one is to be followed.]) rat model for Asherman syndrome (AS). Read More

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http://dx.doi.org/10.1177/1933719118799201DOI Listing
March 2019
2 Reads