1,983 results match your criteria Reproductive Sciences[Journal]


Serum Decorin and Biglycan as Potential Biomarkers to Predict PPROM in Early Gestation.

Reprod Sci 2019 Mar 21:1933719119831790. Epub 2019 Mar 21.

1 Warren Alpert Medical School at Brown University, Providence, RI ,USA.

Preterm birth is a leading cause of neonatal mortality in the US and globally, with preterm premature rupture of fetal membranes (PPROM) accounting for one third of preterm births. Currently no predictive diagnostics are available to precisely assess risk and potentially reduce the incidence of PPROM. Bigycan and decorin, the main proteoglycans present in human fetal membranes, are involved in the physiological maturation of fetal membranes as well as in the pathophysiology of preterm birth. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119831790DOI Listing
March 2019
2 Reads

Genetic Variants Contributing to Early Recurrent Pregnancy Loss Etiology Identified by Sequencing Approaches.

Reprod Sci 2019 Mar 17:1933719119831769. Epub 2019 Mar 17.

1 Center For Research in Genetics and Genomics (CIGGUR), GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.

Recurrent pregnancy loss (RPL) affects up to 5% of couples. It is believed that genetic factors contribute to the disease's etiology and pathophysiology. Hundreds of genes represent coherent RPL candidates due to mammalian implantation's inherent complexity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119831769DOI Listing
March 2019
1 Read

Potential Biomarkers for Ovarian Cancer.

Reprod Sci 2019 Apr;26(4):449

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119833449DOI Listing
April 2019
2 Reads

Activation of Autophagy in Human Uterine Myometrium During Labor.

Reprod Sci 2019 Mar 7:1933719119834351. Epub 2019 Mar 7.

2 Department of Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Objective:: The purpose of this study was to analyze the autophagy of the human uterine myometrium during the labor.

Methods:: We collected uterine myometrium strips from term, singleton, nulliparous healthy women undergoing cesarean delivery before labor (nonlabor group, n = 10) or during normal labor (in-labor group, n = 10) without rupturing of membrane. The indications for cesarean delivery were breech presentation or maternal request. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1933719119834351
Publisher Site
http://dx.doi.org/10.1177/1933719119834351DOI Listing
March 2019
13 Reads

Bradykinin Exerts Independent Effects on Trophoblast Invasion and Blood Pressure in Pregnant Guinea Pigs.

Reprod Sci 2019 Mar 5:1933719119833494. Epub 2019 Mar 5.

3 Departamento de Salud Pública, Facultad de Medicina, Pontificia Universidad Católica, Santiago, Chile.

Introduction:: The pleiotropic kininogen-kallikrein-kinin system is upregulated in pregnancy and localizes in the uteroplacental unit. To identify the systemic and local participation of the bradykinin type 2 receptor (B2R), this was antagonized by Bradyzide (BDZ) during 2 periods: from days 20 to 34 and from days 20 to 60 in pregnant guinea pigs.

Methods:: Pregnant guinea pigs received subcutaneous infusions of saline or BDZ from gestational day 20 until sacrifice on day 34 (Short B2R Antagonism [SH-B2RA]) or on day 60 (Prolonged B2R Antagonism [PR-B2RA]). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119833494DOI Listing
March 2019
1 Read

Effects of Supraphysiologic Levels of Estradiol on Endometrial Decidualization, sFlt1, and HOXA10 Expression.

Reprod Sci 2019 Mar 4:1933719119833485. Epub 2019 Mar 4.

1 Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.

Objective:: Supraphysiologic estradiol (E) levels associated with controlled ovarian hyperstimulation in high in vitro fertilization (IVF) responders may alter implantation and placentation and increase the risk of preeclampsia. Our hypothesis is that elevated E levels in vitro significantly alter endometrial decidualization, sFlt1, and HOXA10 expression.

Methods:: Human endometrial stromal cells were treated with a decidualization cocktail of medroxyprogesterone, cyclic adenosine monophosphate, and 3 concentrations of E 10 nM (standard), 100 nM (intermediate), or 1000 nM E (high). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119833485DOI Listing
March 2019
1 Read

SPOCK2 Affects the Biological Behavior of Endometrial Cancer Cells by Regulation of MT1-MMP and MMP2.

Reprod Sci 2019 Mar 4:1933719119834341. Epub 2019 Mar 4.

1 Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

Abnormal expression of SPARC (osteonectin), cwcv and kazal-like domains proteoglycan 2 (SPOCK2) plays a significant role in the development and progression of various human cancers, yet a relationship between SPOCK2 and endometrial cancer (EC) has not been reported. Here, we assessed the potential role and mechanism by which SPOCK2 acts in the pathogenesis and progression of EC. First, protein expression of SPOCK2 in EC tissue from patients was detected by immunohistochemistry and associated clinical data were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119834341DOI Listing
March 2019
2 Reads

Abnormal Expression of Indoleamine 2, 3-Dioxygenase in Human Recurrent Miscarriage.

Reprod Sci 2019 Mar 4:1933719119833788. Epub 2019 Mar 4.

1 Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.

Indoleamine 2, 3-dioxygenase (IDO), an immunosuppressive enzyme that mediates the conversion of tryptophan to kynurenine, was shown to play a key role in placental development during normal pregnancy. However, little is known about the pattern of IDO expression in the endometrium and its attendant functional significance in pregnancies complicated with recurrent miscarriage (RM). Immunohistochemical studies of IDO, Foxp3, CD56, and CD163 expression were performed in endometrial samples from women with RM and healthy fertile controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119833788DOI Listing
March 2019
3 Reads

Hyperandrogenic Milieu Dysregulates the Expression of Insulin Signaling Factors and Glucose Transporters in the Endometrium of Patients With Polycystic Ovary Syndrome.

Reprod Sci 2019 Mar 4:1933719119833487. Epub 2019 Mar 4.

6 Fertility Center of CHA Bundang Medical Center, CHA University, Seongnam, Korea.

Purpose:: Subfertility associated with polycystic ovary syndrome (PCOS) mainly originates from oligoovulation/anovulation. Although insulin resistance and androgen excess are known to cause PCOS-associated implantation failure, the consequences of PCOS on endometrial homeostasis and pathophysiology have not been comprehensively understood. In this study, we examined whether the pathophysiologic milieu of PCOS intrinsically affects expression profiles of genes related to insulin signaling and facilitative glucose transporters (GLUTs) in the human endometrium and/or during in vitro decidualization. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119833487DOI Listing
March 2019
5 Reads

Expression of Cannabinoid Receptors in Myometrium and its Correlation With Dysmenorrhea in Adenomyosis.

Reprod Sci 2019 Mar 4:1933719119833483. Epub 2019 Mar 4.

1 Department of Minimally Invasive Gynecologic Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, People's Republic of China.

The myometrium, especially the junctional zone (JZ), is now well documented to have a role in the pathogenesis of adenomyosis. Cannabinoid receptors have been shown to participate in the establishment of endometriosis and its pain perception. However, its relation to adenomyosis has not been identified yet. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119833483DOI Listing
March 2019
2 Reads

The Fetal Reserve Index Significantly Outperforms ACOG Category System in Predicting Cord Blood Base Excess and pH: A Methodological Failure of the Category System.

Reprod Sci 2019 Mar 4:1933719119833796. Epub 2019 Mar 4.

1 Fetal Medicine Foundation of America, New York, NY, USA.

Objective:: Electronic fetal monitoring (EFM) has been used extensively for almost 50 years but performs poorly in predicting and preventing adverse neonatal outcome. In recent years, the current "enhanced" classification of patterns (category I-III system [CAT]) were introduced into routine practice without corroborative studies, which has resulted in even EFM experts lamenting its value. Since abnormalities of arterial cord blood parameters correlate reasonably well with risk of fetal injury, here we compare the statistical performance of EFM using the current CAT system with the Fetal Reserve Index (FRI) for predicting derangements in base excess (BE), pH, and pO in arterial cord blood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119833796DOI Listing

Molecular Basis Supporting the Association of Talcum Powder Use With Increased Risk of Ovarian Cancer.

Reprod Sci 2019 Feb 28:1933719119831773. Epub 2019 Feb 28.

1 Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA.

Genital use of talcum powder and its associated risk of ovarian cancer is an important controversial topic. Epithelial ovarian cancer (EOC) cells are known to manifest a persistent prooxidant state. Here we demonstrated that talc induces significant changes in key redox enzymes and enhances the prooxidant state in normal and EOC cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119831773DOI Listing
February 2019
10 Reads

Establishment and Characterization of a Stromal Cell Line Derived From a Patient With Thoracic Endometriosis.

Reprod Sci 2019 Feb 28:1933719119833475. Epub 2019 Feb 28.

5 Service d'Anatomie Pathologique, Institut Mutualiste Montsouris, Paris, France.

Thoracic endometriosis (TE) syndrome is a clinical condition known as an extrapelvic form of endometriosis with the presence of functioning endometrial tissue involving lung parenchyma, pleura, chest wall, or diaphragm. In an effort to obtain an endometriosis ex vivo model, we established the spontaneously growing TH-EM1 cell line from endometriotic implants in lung parenchyma from a woman with TE. Maintained in long-term culture, the cells grew as large mesenchymal-like cells with a doubling time between 5 and 6 days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119833475DOI Listing
February 2019
2 Reads

The Possible Involvement of miR-371a-5p Regulating XIAP in the Pathogenesis of Recurrent Pregnancy Loss.

Reprod Sci 2019 Feb 28:1933719119828051. Epub 2019 Feb 28.

1 Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Apoptosis is an interactive and dynamic biological process involved in all phases of embryogenesis. If apoptosis dominates the trophoblast cell growth process, it will result in adverse pregnancy outcomes. X-linked inhibitor of apoptosis protein (XIAP) is a potent caspase inhibitor and an important barrier to apoptotic cell death. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119828051DOI Listing
February 2019

Acute Glucose Load, Inflammation, Oxidative Stress, Nonenzymatic Glycation, and Screening for Gestational Diabetes.

Reprod Sci 2019 Feb 27:1933719119831772. Epub 2019 Feb 27.

1 Department of Obstetrics & Gynecology, The Ohio State University College of Medicine, Columbus, OH, USA.

Aims:: To investigate if oral glucose tolerance test (OGTT) associates with changes in maternal symptoms (ie, flushing, sweating), blood nonenzymatic advanced glycation end products (AGE), acute-phase reactive inflammatory markers, and oxidative stress.

Methods:: Prospective case-control study of patients screened for gestational diabetes mellitus (GDM). One hundred nonfasting, second-trimester consecutive pregnant women allocated to either 50 g OGTT or water. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119831772DOI Listing
February 2019
1 Read

LIM Kinase 1 Mediates Estradiol Effects on the Phosphorylation of Cofilin1 in Eutopic Endometrial Stromal Cells During the Invasion and Proliferation of Endometriosis.

Reprod Sci 2019 Feb 26:1933719119828076. Epub 2019 Feb 26.

1 Department of Gynecology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, People's Republic of China.

Endometriosis is an estrogen-dependent gynecological disease; however, the mechanism by which estradiol promotes the development of endometriosis, including invasion and proliferation, remains unclear. Estradiol is involved in cell invasion and proliferation by regulating the cytoskeleton. The abnormally high expression of cytoskeletal regulators (LIM kinase 1 [LIMK1] and cofilin1) is closely related to increased invasiveness and proliferation of eutopic endometrial stromal cells from endometriosis patients compared to normal eutopic endometrial cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119828076DOI Listing
February 2019
1 Read

Anethole Supplementation During Oocyte Maturation Improves In Vitro Production of Bovine Embryos.

Reprod Sci 2019 Feb 26:1933719119831783. Epub 2019 Feb 26.

1 Laboratory of Manipulation of Oocytes and Preantral Follicles (LAMOFOPA), Faculty of Veterinary Medicine, State University of Ceara, Fortaleza, Ceara, Brazil.

Oxidative stress is one of the most detrimental factors that affect oocyte developmental competence and embryo development in vitro. The impact of anethole supplementation to in vitro maturation (IVM) media on oocyte maturation and further bovine in vitro embryo production was investigated. Oocytes of slaughterhouse-derived bovine ovaries were placed in IVM with anethole at different concentrations of 30 (AN30), 300 (AN300), and 2000 μg/mL (AN2000), or without (control treatment). Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1933719119831783
Publisher Site
http://dx.doi.org/10.1177/1933719119831783DOI Listing
February 2019
6 Reads

The Exosomal Long Noncoding RNA aHIF is Upregulated in Serum From Patients With Endometriosis and Promotes Angiogenesis in Endometriosis.

Reprod Sci 2019 Feb 26:1933719119831775. Epub 2019 Feb 26.

1 Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.

Objective:: The transfer of long noncoding RNAs (lncRNAs) via exosomes to modulate recipient cells represents an important mechanism for disease progression. Antisense hypoxia-inducible factor (aHIF) is a well-known angiogenesis-related lncRNA. Here, we aimed to investigate the clinical implications of aHIF and exosomal aHIF in endometriosis and the involvement of exosome-shuttled aHIF in endometriosis angiogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119831775DOI Listing
February 2019

Can Pregnancies Be Achieved in Premature Ovarian Insufficiency?

Reprod Sci 2019 02;26(2):157-158

1 Department of Obstetrics and Gynecology, Florida International University Herbert Wertheim College of Medicine, Miami, FL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719118823597DOI Listing
February 2019

CD97 Is Decreased in Preeclamptic Placentas and Promotes Human Trophoblast Invasion Through PI3K/Akt/mTOR Signaling Pathway.

Reprod Sci 2019 Feb 21:1933719119828067. Epub 2019 Feb 21.

1 Department of Obstetrics and Gynecology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.

Preeclampsia (PE) is a pregnancy disorder leading to the morbidity and mortality. Despite the development of the understanding of etiology, the only effective treatment of PE is the delivery of the placenta. An improved mastery on the regulation of trophoblast invasion could be meaningful to alleviate the disease burden of PE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119828067DOI Listing
February 2019
1 Read

Suppressed Immune-Related Profile Rescues Abortion-Prone Fetuses: A Novel Insight Into the CBA/J × DBA/2J Mouse Model.

Reprod Sci 2019 Feb 21:1933719119828042. Epub 2019 Feb 21.

1 Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.

The adverse clinical result and poor treatment outcome in recurrent spontaneous abortion (RSA) make it necessary to understand the pathogenic mechanism. The mating combination CBA/J × DBA/2 has been widely used as an abortion-prone model compared to DBA/2-mated CBA/J mice. Here, we used RNA-seq to get a comprehensive catalogue of genes differentially expressed between survival placenta in abortion-prone model and control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119828042DOI Listing
February 2019
1 Read

Diminished Ovarian Reserve Chemotherapy-Induced Mouse Model: A Tool for the Preclinical Assessment of New Therapies for Ovarian Damage.

Reprod Sci 2019 Feb 21:1933719119831784. Epub 2019 Feb 21.

1 IVI Foundation, Valencia Spain.

Diminished ovarian reserve (DOR) and primary ovarian insufficiency (POI) are primary factors leading to infertility. However, there is a lack of appropriate animal models of DOR usable for assessing new therapeutic strategies. In this study, we aimed to evaluate whether chemotherapy treatment in mice could reproduce features similar of that observed in women with DOR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119831784DOI Listing
February 2019
2 Reads

The Effect of Atosiban on Patients With Difficult Embryo Transfers Undergoing In Vitro Fertilization-Embryo Transfer.

Reprod Sci 2019 Feb 21:1933719119831791. Epub 2019 Feb 21.

1 Department of Gynecology and Obstetrics, Qilu Hospital, Shandong University, Jinan, People's Republic of China.

The purpose of this study was to evaluate the effect of atosiban on the outcomes of infertile women undergoing in vitro fertilization (IVF) with difficult embryo transfers (ETs). This randomized double-blind study enrolled 204 infertile women with difficult ETs during IVF treatment between June 2014 and June 2018. According to a computer-generated randomization list, participants were randomized into placebo (n = 102) and atosiban (n = 102) groups. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1933719119831791
Publisher Site
http://dx.doi.org/10.1177/1933719119831791DOI Listing
February 2019
2 Reads

Diagnosis of Placental Position by Early First-Trimester Ultrasound: A Pilot Study.

Reprod Sci 2019 Feb 21:1933719119831778. Epub 2019 Feb 21.

1 Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN, USA.

Objective:: Conventional wisdom is that placental location cannot be identified before 8 weeks' gestation when the placenta first becomes hyperechogenic on ultrasound. We sought to evaluate whether placental location could be reliably diagnosed between 5 and 6 weeks' gestation.

Materials And Methods:: This was a retrospective analysis of prospectively acquired data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119831778DOI Listing
February 2019
3 Reads

Fetal Membrane Organ-On-Chip: An Innovative Approach to Study Cellular Interactions.

Reprod Sci 2019 Feb 21:1933719119828084. Epub 2019 Feb 21.

1 Division of Maternal-Fetal Medicine & Perinatal Research, Department of Obstetrics & Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA.

Objective:: Fetal membranes, a vital component that helps maintain pregnancy and contribute to parturition signaling, are often studied in segments due to its structural complexity. Transwells are traditionally used to study cell interactions; however, their usefulness is limited. To overcome these difficulties, a fetal membrane-organ-on-chip (FM-OO-C) was created to study interactive properties of amnion epithelial cells (AECs) and decidual cells compared to transwell systems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119828084DOI Listing
February 2019
1 Read

IFITM1 is a Novel, Highly Sensitive Marker for Endometriotic Stromal Cells in Ovarian and Extragenital Endometriosis.

Reprod Sci 2019 Feb 21:1933719119831782. Epub 2019 Feb 21.

1 Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan.

When the presence of endometriotic lesions are not evident by hematoxylin and eosin staining, CD10 is used to highlight and confirm the presence of endometriotic stroma. However, CD10 is not specific only to the endometrial stroma but is also expressed in many other cells. Recently, interferon-inducible transmembrane protein 1 (IFITM1) was reported as a highly specific immunohistochemical marker of normal endometrial stroma and endometrial stromal neoplasm. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119831782DOI Listing
February 2019
4 Reads

Progesterone Receptor B ( PGR-B) Is Partially Methylated in Eutopic Endometrium From Infertile Women With Endometriosis.

Reprod Sci 2019 Feb 19:1933719119828078. Epub 2019 Feb 19.

1 Human Reproduction Division, Department of Obstetrics and Gynecology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil.

Endometriosis is frequently related to infertility and little is known about the mechanisms underlying this association. Some studies point to an endometrial factor involved in this condition, which could compromise embryo implantation. Progesterone plays crucial role in endometrial receptivity by acting through progesterone receptor ( PGR) isoforms PR-A and PR-B whose expression is epigenetically regulated by DNA methylation, in a specific promoter region for each isoform. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119828078DOI Listing
February 2019
1 Read

Sphingosine 1 Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells.

Reprod Sci 2019 Feb 19:1933719119828112. Epub 2019 Feb 19.

1 Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.

Objects:: There is growing evidence that sphingosine 1-phosphate (S1P) is involved in inflammatory diseases. As endometriosis is known as an inflammatory disease, we investigated the role of S1P system in the development of endometriosis.

Methods:: The expression of sphingosine kinase (SphK) 1 in endometriosis lesions was examined by immunohistochemistry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119828112DOI Listing
February 2019
3 Reads

Rapamycin Corrects T Regulatory Cell Depletion and Improves Embryo Implantation and Live Birth Rates in a Murine Model.

Reprod Sci 2019 Feb 19:1933719119828110. Epub 2019 Feb 19.

1 National Institute of Child Health and Human Development, Bethesda, MD, USA.

There are few treatments for patients with recurrent pregnancy loss (RPL) or recurrent implantation failure (RIF). Women with RPL and unexplained infertility have lower T regulatory cell (T) expression when compared to fertile controls. A murine model has been developed with depletion of regulatory T cells (DEREG) after administration of diphtheria toxin (DT), resulting in smaller litter sizes, secondary to embryo implantation failure. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1933719119828110
Publisher Site
http://dx.doi.org/10.1177/1933719119828110DOI Listing
February 2019
5 Reads

Downregulation of MicroRNA-125a in Placenta Accreta Spectrum Disorders Contributes Antiapoptosis of Implantation Site Intermediate Trophoblasts by Targeting MCL1.

Reprod Sci 2019 Feb 19:1933719119828040. Epub 2019 Feb 19.

1 Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, People's Republic of China.

The typical hallmark of placenta accreta spectrum (PAS) disorders is increased implantation site intermediate trophoblast (ISIT) cell numbers. However, the extent of trophoblast proliferation and apoptosis have not been found to differ from those of normal placentation. MicroRNA-125a (miR-125a) induces apoptosis in colon cancer cell by targeting myeloid cell leukemia-1 gene ( MCL1). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119828040DOI Listing
February 2019
3 Reads

Gestational and Hormonal Effects on Magnesium Sulfate's Ability to Inhibit Mouse Uterine Contractility.

Reprod Sci 2019 Feb 17:1933719119828089. Epub 2019 Feb 17.

1 Department of Cellular and Molecular Physiology, University Department, Harris-Wellbeing Preterm Birth Research Centre, The Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

Magnesium sulfate is used as a tocolytic, but clinical efficacy has been seriously questioned. Our objective was to use controlled ex vivo conditions and known pregnancy stages, to investigate how 2 key factors, hormones and gestation, affect magnesium's tocolytic ability. We hypothesized that these factors could underlie the varying clinical findings around magnesium's efficacy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119828089DOI Listing
February 2019
1 Read

Reduction in FSH Throughout the Menstrual Cycle After Omega-3 Fatty Acid Supplementation in Young Normal Weight but not Obese Women.

Reprod Sci 2019 Feb 17:1933719119828099. Epub 2019 Feb 17.

1 Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, USA.

Dietary fish oil restores ovarian function in subfertile rats, which is thought to be associated with decreased transcription of follicle-stimulating hormone (FSH) β-subunit. We have previously demonstrated a reduction in early follicular serum FSH levels in normal weight but not obese women after treatment with omega-3 polyunsaturated fatty acids (PUFA). Herein, we report the effect of supplementation with omega-3 PUFA on urinary reproductive hormones across the whole menstrual cycle. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119828099DOI Listing
February 2019
2 Reads

Lipoxin A Suppresses IL-1β-Induced Cyclooxygenase-2 Expression Through Inhibition of p38 MAPK Activation in Endometriosis.

Reprod Sci 2019 Feb 17:1933719119828115. Epub 2019 Feb 17.

1 Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, Xiamen, People's Republic of China.

Endometriosis is an inflammation-dependent gynecologic disorder. Increased cyclooxygenase-2 (COX-2) expression plays an important role in the development and progression of endometriosis. Lipoxin A (LXA) is an endogenous anti-inflammation lipid and showed inhibitory effects on the development of endometriosis; however, the mechanism remains unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119828115DOI Listing
February 2019
1 Read

Ovarian Reserve Reduction With Surgery Is Not Correlated With the Amount of Ovarian Tissue Inadvertently Excised at Laparoscopic Surgery for Endometriomas.

Reprod Sci 2019 Feb 14:1933719119828055. Epub 2019 Feb 14.

1 Department of Obstetrics and Gynecology, "Sapienza" University of Rome, Rome, Italy.

The aim of the present study was to evaluate the effect of laparoscopic cystectomy on ovarian reserve by means of anti-Müllerian hormone (AMH) serial measurements and to compare AMH values with the number of inadvertently removed follicles in histological specimens. Fifty-two women were enrolled: 34 patients with endometriomas (group 1) and 18 patients with other benign ovarian cysts (group 2). All patients underwent laparoscopic cystectomy performed by a single experienced surgeon. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119828055DOI Listing
February 2019
1 Read

PAX8: A Highly Sensitive Marker for the Glands in Extragenital Endometriosis.

Reprod Sci 2019 Feb 14:1933719119828095. Epub 2019 Feb 14.

1 Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan.

In cases of extragenital endometriosis or microscopic endometriosis lesions, pathological diagnosis can be challenging because endometriotic stroma and glands represent only a minor component of fibrotic endometriotic lesions. For better accuracy of diagnosis, the development of a sensitive and specific epithelial marker is beneficial. Previous studies showed that PAX8 is a highly sensitive and specific marker for primary and metastatic Mullerian epithelial tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119828095DOI Listing
February 2019
3 Reads

Perioperative Intervention by β-Blockade and NF-κB Suppression Reduces the Recurrence Risk of Endometriosis in Mice Due to Incomplete Excision.

Reprod Sci 2019 Feb 14:1933719119828066. Epub 2019 Feb 14.

1 Shanghai OB/GYN Hospital, Fudan University, Shanghai, China.

Despite the demonstrated efficacy of surgical treatment of endometriosis, recurrence after surgery still remains a formidable challenge. Surgery, especially when performed repeatedly, decreases ovarian reserve. Clearly, control of recurrence is an unmet medical need. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119828066DOI Listing
February 2019
1 Read

Expression, Regulation, and Function of the Calmodulin Accessory Protein PCP4/PEP-19 in Myometrium.

Reprod Sci 2019 Feb 11:1933719119828072. Epub 2019 Feb 11.

1 Department of Obstetrics and Gynecology, Division of Research, University of Kansas School of Medicine, Kansas City, KS, USA.

Objective:: Calmodulin (CaM) plays a key role in the orchestration of Ca signaling events, and its regulation is considered an important component of cellular homeostasis. The control of uterine smooth muscle function is largely dependent on the regulation of Ca and CaM signaling. The objective of this study was to investigate the expression, function, and regulation of CaM regulatory proteins in myometrium during pregnancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119828072DOI Listing
February 2019
10 Reads

Fetal Growth Restriction Is Associated With Decreased Number of Ovarian Follicles and Impaired Follicle Growth in Young Adult Guinea Pig Offspring.

Reprod Sci 2019 Feb 11:1933719119828041. Epub 2019 Feb 11.

1 Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.

Background:: The mechanisms mediating the impacts of fetal growth restriction (FGR) on follicular development are commonly studied in mouse/rat models, where ovarian development occurs largely during the early postnatal period. These models have shown that FGR is associated with premature follicle loss, early pubertal onset, and accelerated ovarian aging. Whether the same occurs in precocious species is unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119828041DOI Listing
February 2019
2 Reads

Antibody Microarray Analysis of Plasma Proteins for the Prediction of Histologic Chorioamnionitis in Women With Preterm Premature Rupture of Membranes.

Reprod Sci 2019 Feb 6:1933719119828043. Epub 2019 Feb 6.

2 Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, South Korea.

We aimed to identify maternal blood biomarkers predictive of histologic chorioamnionitis (HCA) in the plasma of women with preterm premature rupture of membranes (PPROM) and to determine whether the combination of these biomarkers with conventional clinical variables can improve the prediction of HCA. This retrospective cohort study included 82 consecutive women with PPROM (23-34 gestational weeks) who delivered within 96 hours of blood sampling. A membrane-based human antibody microarray was used to analyze the plasma proteome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719119828043DOI Listing
February 2019
1 Read

Evaluation of Sperm DNA Fragmentation via Halosperm Technique and TUNEL Assay Before and After Cryopreservation.

Reprod Sci 2019 Feb 4:1933719119828096. Epub 2019 Feb 4.

5 Department of Obstetrics and Gynecology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Acibadem Altunizade Hospital, Unit of ART, Istanbul, Turkey.

Aim:: Human sperm DNA fragmentation is one of the factors suggested for male infertility. The ratio of sperm DNA damage in semen may adversely affect both the fertilization rate and the embryo development of in vitro fertilization/ intracytoplasmic sperm injection cycles. Sperm cryopreservation both increases the success rates in assisted reproductive techniques (ARTs) and contributes to the preservation of fertility before testis surgery, chemotherapy, and radiotherapy. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1933719119828096
Publisher Site
http://dx.doi.org/10.1177/1933719119828096DOI Listing
February 2019
7 Reads

Not Having Been Breastfed May Protect Chinese Women From Developing Deep Infiltrating Endometriosis: Results From Subgroup Analyses of the FEELING Study.

Reprod Sci 2019 Jan 22:1933719118820469. Epub 2019 Jan 22.

1 Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Background:: This study aimed to investigate potential factors, especially early-life exposures, associated with endometrioma (OMA) and/or deep infiltrating endometriosis (DIE) in Chinese women.

Methods:: This is a subgroup analyses of the FEELING study, which was a case-control study that investigated the clinical, lifestyle, and environmental factors associated with OMA and/or DIE in China, Russia, and France. In this subgroup analysis, the data for the Chinese participants were further analyzed using logistic regression model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719118820469DOI Listing
January 2019
4 Reads

Cervix Stromal Cells and the Progesterone Receptor A Isoform Mediate Effects of Progesterone for Prepartum Remodeling.

Reprod Sci 2019 Jan 17:1933719118820462. Epub 2019 Jan 17.

1 Longo Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, USA.

The prepartum transition from a soft to ripening cervix is an inflammatory process that occurs well before birth when systemic progesterone is near peak concentration. This 2-part study first determined that stromal fibroblasts but not macrophages in the cervix have progesterone receptors (PRs). Neither the number of PR cells in cervix sections nor the relative abundance or ratio of nuclear PR isoforms (PR-A/PR-B) were diminished in mice between day 15 of pregnancy and term. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719118820462DOI Listing
January 2019
2 Reads

Regulation of CX3CL1 Expression in Human First-Trimester Decidual Cells: Implications for Preeclampsia.

Reprod Sci 2019 Jan 3:1933719118815592. Epub 2019 Jan 3.

2 Department of Obstetrics and Gynecology, University of South Florida, Tampa, FL, USA.

C-X3-C motif ligand 1 (CX3CL1) mediates migration, survival, and adhesion of natural killer (NK) cells, monocytes, and T-cells to endothelial/epithelial cells. Aberrant numbers and/or activation of these decidual immune cells elicit preeclampsia development. Decidual macrophages and NK cells are critical for implantation, while macrophage-derived tumor necrosis factor-α (TNF-α), interleukin-1 β (IL-1β), and NK cell-derived interferon-γ (IFN-γ) are associated with preeclampsia development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719118815592DOI Listing
January 2019
15 Reads

Metformin Regulates Key MicroRNAs to Improve Endometrial Receptivity Through Increasing Implantation Marker Gene Expression in Patients with PCOS Undergoing IVF/ICSI.

Reprod Sci 2019 Jan 1:1933719118820466. Epub 2019 Jan 1.

1 Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.

To some extent, the use of metformin may improve endometrial receptivity and pregnancy outcomes of women with polycystic ovarian syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection. However, the mechanism is not well-known. The endometrium of metformin-treated group (metformin-treated patients with PCOS) and the control group (non-metformin-treated patients with PCOS) were analyzed for the expression of homeobox A10 (HOXA10) and integrin beta-3 (ITGB3) and differential micro RNA (miRNA) expression profiles. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719118820466DOI Listing
January 2019
11 Reads

Increased Expression of KISS1 and KISS1 Receptor in Human Granulosa Lutein Cells-Potential Pathogenesis of Polycystic Ovary Syndrome.

Reprod Sci 2018 Dec 30:1933719118818899. Epub 2018 Dec 30.

1 Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Kisspeptins are a family of neuropeptides that are essential for fertility. Recent experimental data suggest a putative role of kisspeptin signaling in the direct control of ovarian function. To explore the expression of KISS1 and KISS1 receptor (KISS1R) in human granulosa lutein cells and the potential role of KISS1/KISS1R system in the pathogenesis of polycystic ovary syndrome (PCOS), we measured the concentration of KISS1 in follicular fluid, the expression of KISS1 and KISS1R in granulosa lutein cells, and the circulating hormones. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719118818899DOI Listing
December 2018
7 Reads

Decreased Ang-(1-7) and Downregulated Intrarenal RAS May Contribute to the Direct Podocyte Injury With Proteinuria in Preeclampsia.

Reprod Sci 2018 Dec 30:1933719118813200. Epub 2018 Dec 30.

1 Division of Nephrology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, People's Republic of China.

The mechanisms of proteinuria development in preeclampsia (PE) are still enigmatic. Renin-angiotensin system (RAS) components may play a role. Maternal serum and urinary concentrations of angiotensin-(1-7) [Ang-(1-7)], angiotensin II (Ang II), and angiotensinogen in women with PE (n = 14), gestational hypertension (n = 14), and normal pregnancy were quantified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719118813200DOI Listing
December 2018
2 Reads

Regulation of Embryonic Signal on Talin1 in Mouse Endometrium.

Reprod Sci 2018 Dec 20:1933719118815584. Epub 2018 Dec 20.

1 Department of Reproductive Center, First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Embryonic signals can affect the spatiotemporal-specific expression of the uterus to establish a successful pregnancy. Our previous study has found that talin1 underwent dynamic changes in the mouse endometrium during peri-implantation period. However, whether talin1 is affected by the embryo signals is not clear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1933719118815584DOI Listing
December 2018
1 Read