3,310 results match your criteria Reproduction[Journal]


Tri-ortho-cresyl phosphate induces autophagy of mouse ovarian granulosa cells.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

J Chen, Department of Physiology, Medical College of Nanchang University, Nanchang, China.

Tri-ortho -cresyl phosphate (TOCP) has been widely used as plasticizers, plastic softeners, and flame-retardants in industry and reported to have male reproductive toxicology. However, it is still unknown whether TOCP affects the female reproductive system and its underlying mechanism. In the present study, we found that TOCP exposure significantly decreased ovarian coefficient, caused disintegration and depletion of the granulosa cells in the ovary tissue and significantly inhibited the level of serum estradiol (E2). Read More

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https://rep.bioscientifica.com/view/journals/rep/aop/rep-18-
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http://dx.doi.org/10.1530/REP-18-0456DOI Listing
April 2019
1 Read

Effects of a n-3 PUFA enriched diet on embryo production in dairy cows.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

S Elis, CNRS, IFCE, INRA, Université de Tours, PRC, Nouzilly, France.

Beneficial effects of n-3 polyunsaturated fatty acid (PUFA) supplementation on dairy cow reproduction have been previously reported. The objectives of the present study were to assess whether n-3 PUFA supplementation would affect in vitro embryo production (IVP) after ovarian stimulation. Holstein cows received a diet with 1% dry matter supplementation of either n-3 PUFA (n = 18, micro encapsulated fish oil) or a control, n-6 PUFA (n = 19, micro encapsulated soy oil). Read More

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http://dx.doi.org/10.1530/REP-18-0644DOI Listing

Reproductive science and the future of the planet.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

B Wong, School of Biological Sciences, Monash University, Clayton, Australia.

Reproductive sciences have made major contributions to human health, livestock production and environmental management in the past and will continue to do so in future. In collaboration with other disciplines, reproductive scientists can provide scientifically valid information that will allow the rational development of policies on topics such as declining fertility in men and women, livestock breeding efficiencies, climate change, pest animal control, wildlife management and environmental influences. It is imperative that the reproductive sciences are recognised by the community and policy makers as important contributors to future health and welfare of animals, humans and the planet if these potential benefits are to be captured and utilized. Read More

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http://dx.doi.org/10.1530/REP-18-0640DOI Listing

Role of Nodal signalling in testis development and initiation of testicular cancer.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

A Jorgensen, Department of Growth and Reproduction, Rigshospitalet, Kobenhavn, Denmark.

Testicular development from the initially bipotential gonad is a tightly regulated process involving a complex signalling cascade to ensure proper sequential expression of signalling factors and secretion of steroid hormones. Initially, Sertoli cell specification facilitates differentiation of the steroidogenic fetal Leydig cells and establishment of the somatic niche, which is critical in supporting the germ cell population. Impairment of the somatic niche during fetal life may lead to development of male reproductive disorders, including arrest of gonocyte differentiation, which is considered the first step in the testicular cancer pathogenesis. Read More

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https://rep.bioscientifica.com/view/journals/rep/aop/rep-18-
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http://dx.doi.org/10.1530/REP-18-0641DOI Listing
April 2019
1 Read

Obesity Induces Ovarian Inflammation and Reduces Oocyte Quality.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

J Wood, Animal Science, University of Nebraska, Lincoln, 68583-0908, United States.

In the US, 36.5 percent of women between the ages of 20-39 are obese. This obesity results in not only metabolic disorders including type II diabetes and cardiovascular disease, but also impaired female fertility. Read More

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https://rep.bioscientifica.com/view/journals/rep/aop/rep-18-
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http://dx.doi.org/10.1530/REP-18-0583DOI Listing
April 2019
5 Reads

Totipotency continuity from zygote to early blastomeres - a model under revision.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

E Christians, CNRS, Laboratoire de Biologie du Développement de Villefranche sur Mer (LBDV), 181, Chemin du Lazaret, Sorbonne Université, 06230 Villefranche sur Mer, France.

The mammalian zygote is a totipotent cell that generates all the cells of a new organism through embryonic development. However, if one asks about the totipotency of blastomeres after one or two zygotic divisions, opinions differ. As it is impossible to determine the intrinsic developmental potency of early blastomeres in an intact embryo, experiments of blastomere isolation were conducted in various species, showing that 2-cell blastomeres could give rise to a new organism when sister cells were separated. Read More

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http://dx.doi.org/10.1530/REP-18-0462DOI Listing
April 2019
3 Reads

Endometriosis in MRKH Cases as a Proof for the Coelomic Metaplasia Hypothesis?

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

I Meinhold-Heerlein, Institute of Gynecology and Obstetrics, Justus Liebig Universitat Giessen, Giessen, Germany.

The diagnosis of endometriosis is based upon the histological identification of endometrial tissue at ectopic sites which are commonly located on the pelvic organs, the peritoneum and ovary. In rare cases, ectopic lesions can be found in other organs, such as kidney, bladder, lung or brain. Diagnosis is achieved by laparoscopic intervention followed by histological confirmation of endometriotic tissue. Read More

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https://rep.bioscientifica.com/view/journals/rep/aop/rep-19-
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http://dx.doi.org/10.1530/REP-19-0106DOI Listing
April 2019
3 Reads

Artificial intelligence in reproductive medicine.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

S Liao, Department of Obstetrics and Gynecology, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Artificial intelligence (AI) has experienced rapid growth over the past few years, moving from the experimental to the implementation phase in various fields, including medicine. Advances in learning algorithms and theories, the availability of large datasets, and improvements in computing power have contributed to breakthroughs in current AI applications. Machine learning (ML), a subset of AI, allows computers to detect patterns from large complex datasets automatically and uses these patterns to make predictions. Read More

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http://dx.doi.org/10.1530/REP-18-0523DOI Listing
April 2019
3 Reads

DNA Methylation in the Pathogenesis of Polycystic Ovary Syndrome.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

M Cerbón, Faculty of Chemistry, National autonomous University of Mexico, D.F., Mexico.

Polycystic ovary syndrome (PCOS) is the leading endocrine and metabolic disorder in premenopausal women characterized by hyperandrogenism and abnormal development of ovarian follicles. To date, the PCOS etiology remains unclear and has been related to insulin resistance, obesity, type 2 diabetes mellitus, cardiovascular disease, and infertility, among other morbidities. Substantial evidence illustrates the impact of genetic, intrauterine, and environmental factors on the PCOS etiology. Read More

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https://rep.bioscientifica.com/view/journals/rep/aop/rep-18-
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http://dx.doi.org/10.1530/REP-18-0449DOI Listing
April 2019
11 Reads

Microtubule depolymerization attenuates WNT4/CaMKIIα signaling in mouse uterus and leads to implantation failure.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

A Dwivedi, Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.

Microtubule (MT) dynamics plays a crucial role in fertilization and early embryonic development but its involvement in uterus during embryo implantation remains unclear. Herein, we report the effect of microtubule depolymerization during embryo implantation in BALB/c mice. Intra-uterine treatment with depolymerizing agent nocodazole at pre-implantation phase (D4, 0700h) in mice resulted into mitigation in receptivity markers viz. Read More

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http://dx.doi.org/10.1530/REP-18-0611DOI Listing
April 2019
2 Reads

Regulation of long non-coding RNAs and circular RNAs in spermatogonial stem cells.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

Z He, Basic Medicine, Hunan Normal University School of Medicine, Changsha, China.

Spermatogonial stem cells (SSCs) are one of the most significant stem cells with the potentials of self-renewal, differentiation, transdifferentiation and dedifferentiation, and thus they have important applications in reproductive and regenerative medicine. They can transmit the genetic and epigenetic information across generations, which highlights the importance of the correct establishment and maintenance of epigenetic marks. Accurate transcriptional and post-transcriptional regulation is required to support the highly coordinated expression of specific genes for each step of spermatogenesis. Read More

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http://dx.doi.org/10.1530/REP-18-0517DOI Listing
April 2019
1 Read

Uterine fluid proteome changes during diapause and resumption of embryo development in roe deer.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

S Ulbrich, Animal Physiology, Institute of Agricultural Sciences, ETH Zurich, Zurich, Switzerland.

The uterine microenvironment during pre-implantation presents a pro-survival milieu, and is essential for embryo elongation in ruminants. The European roe deer (Careolus capreolus) pre-implantation embryo development is characterised by a 4-month period of reduced development, embryonic diapause, after which the embryo rapidly elongates and implants. We investigated the uterine fluid proteome by label-free liquid chromatography tandem mass spectrometry at four defined stages covering the phase of reduced developmental pace (early diapause, mid diapause, and late diapause) and embryo elongation. Read More

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http://dx.doi.org/10.1530/REP-19-0022DOI Listing
April 2019
7 Reads

Effect of the Neuropeptide Phoenixin and Its Receptor GPR173 During Folliculogenesis.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

F Kikkawa, Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Folliculogenesis is a complex process, defined by the growth and development of follicles from the primordial population. Granulosa cells (GCs) play a vital role in every stage of follicular growth through proliferation, acquisition of gonadotropic responsiveness, steroidogenesis, and production of autocrine/paracrine factors. A recently discovered hypothalamic neuropeptide phoenixin, is involved in the regulation of the reproductive system. Read More

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http://dx.doi.org/10.1530/REP-19-0025DOI Listing

Persistent effects on bovine granulosa cell transcriptome after resolution of uterine disease.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

J Bromfield, Animal Sciences, University of Florida, Gainesville, 32611, United States.

Metritis is associated with reduced fertility in dairy cows, but the mechanisms are unclear because the disease resolves several weeks before insemination. One hypothesis is that metritis causes persistent changes in granulosa cells during follicle development, which might be evident in the transcriptome of granulosa cells from dominant follicles weeks after parturition. To test this hypothesis we collected follicular fluid and granulosa cells from dominant follicles 63 days post partum from cows previously diagnosed with metritis, at least 6 weeks after resolution of the disease, and from cows not diagnosed with metritis (control cows). Read More

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http://dx.doi.org/10.1530/REP-19-0037DOI Listing

Interleukin in endometriosis-associated infertility-pelvic pain: systematic review and meta-analysis.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

S Podgaec, Jewish Teaching and Research Institute, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.

The objective is to study the significance of altered interleukin levels in endometriosis-related infertility or pelvic pain. The present systematic review and meta-analysis includes a discussion on interleukin roles in the physiopathology of endometriosis-associated infertility and/or pelvic pain. We included all studies in which interleukins in peritoneal fluid, follicular fluid or serum from patients were measured and that correlated the findings with either peritoneal or deep endometriosis-associated infertility or pelvic pain. Read More

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http://dx.doi.org/10.1530/REP-18-0618DOI Listing
April 2019
2 Reads

Transcriptome analyses of ovarian stroma; tunica albuginea, interstitium and theca interna.

Reproduction 2019 Mar 1. Epub 2019 Mar 1.

H Irving-Rodgers, School of Medical Science, Griffith University - Gold Coast Campus, Southport, Australia.

The ovary has specialised stromal compartments, including the tunica albuginea, interstitial stroma and theca interna, which develops concurrently with the follicular antrum. To characterise the molecular determinants of these compartments, stroma adjacent to preantral follicles (pre-theca), interstitium and tunica albuginea were laser microdissected (n = 4 per group) and theca interna was dissected from bovine antral follicles (n = 6). RNA microarray analysis showed minimal differences between interstitial stroma and pre-theca, and these were combined for some analyses and referred to as stroma. Read More

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http://dx.doi.org/10.1530/REP-18-0323DOI Listing

The biological mechanisms regulating sperm selection by the ovine cervix.

Reproduction 2019 Mar 1. Epub 2019 Mar 1.

S de Graaf, Faculty of Veterinary Science, The University of Sydney, The University of Sydney, Australia.

In species where semen is deposited in the vagina, the cervix has the unique function of facilitating progress of spermatozoa towards the site of fertilisation while also preventing the ascending influx of pathogens from the vagina. For the majority of species, advances in assisted reproduction techniques facilitate the bypassing of the cervix and therefore its effect on the transit of processed spermatozoa has been largely overlooked. The exception is in sheep, as it is currently not possible to traverse the ovine cervix with an inseminating catheter due to it's complex anatomy, and semen must be deposited at the external cervical os. Read More

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http://dx.doi.org/10.1530/REP-18-0595DOI Listing

Maladaptation of trout spermatozoa to fresh water is related to oxidative stress and proteome changes.

Reproduction 2019 Jun;157(6):485-499

Department of Gametes and Embryo Biology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.

Rainbow trout sperm are 'maladapted' to freshwater spawning, resulting in shorter duration of sperm motility in fresh water compared to buffered saline solution. We hypothesized that different sperm motility-activating media have various effects on sperm motility characteristics and oxidative stress, as well as on the protein profiles of rainbow trout sperm. We designed an experimental model for activation of rainbow trout sperm motility in different osmotic conditions: (i) isosmotic and (ii) hypoosmotic. Read More

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http://dx.doi.org/10.1530/REP-19-0012DOI Listing

Errors and Insight: Intentional and accidental studies of human chromosome abnormalities.

Authors:
Pat Hunt

Reproduction 2019 Mar 1. Epub 2019 Mar 1.

P Hunt, smb, washington state university, pullman, 99164-4660, United States.

Synopsis: Perhaps every career makes sense in retrospect. I've spent mine facing a series of accidental environmental exposures that derailed our studies but provided new insight. Although at times I have felt more catalyst than scientist, the journey has been extraordinary, and the problem I have spent my career studying - human aneuploidy - has taken on new significance with growing evidence of the sensitivity of the germline to the environment. Read More

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http://dx.doi.org/10.1530/REP-19-0013DOI Listing

Genome-wide profiling of miRNA expression patterns in tubal endometriosis.

Reproduction 2019 Mar 1. Epub 2019 Mar 1.

J Zhang, Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200030, China.

MicroRNA (miRNA) expression profiles in tubal endometriosis (EM) are still poorly understood. In this study, we analyzed the differential expression of miRNAs and the related gene networks and signaling pathways in tubal EM. Four tubal epithelium samples from tubal EM patients and five normal tubal epithelium samples from uterine leiomyoma patients were collected for miRNA microarray. Read More

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http://dx.doi.org/10.1530/REP-18-0631DOI Listing
March 2019
1 Read
3.174 Impact Factor

AC002454.1 and CDK6 synergistically promote Endometrial Cell Migration and Invasion in Endometriosis.

Reproduction 2019 Mar 1. Epub 2019 Mar 1.

D Wang, Department of Gynecology, Cancer Hospital of China Medical University,Liaoning Cancer Hospital and Institute, Shenyang, China.

Previous lncRNA microarray screening found that the AC002454.1 gene was highly expressed in Endometriosis (EMS) and these expression levels were highly correlated with cyclin-dependent kinase-6 (CDK6). This study investigated the expression level and correlation between AC002454. Read More

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http://dx.doi.org/10.1530/REP-19-0005DOI Listing
March 2019
2 Reads

Multiple superovulations alter histone modifications in mouse early embryos.

Reproduction 2019 Mar 1. Epub 2019 Mar 1.

Q Sun, State Kay Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

It is demonstrated that repeated superovulation has deleterious effects on mouse ovaries and cumulus cells. However, little is known about the effects of repeated superovulation on early embryos. Epigenetic reprogramming is an important event in early embryonic development, and could be easily disrupted by the environment. Read More

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http://dx.doi.org/10.1530/REP-18-0495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454231PMC
March 2019
1 Read
3.174 Impact Factor

HASPIN kinase mediates histone deacetylation to regulate oocyte meiotic maturation in pigs.

Reproduction 2019 Mar 1. Epub 2019 Mar 1.

Y Zhang, College of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.

HASPIN kinase-catalyzed phosphorylation of histone H3 on threonine 3 (H3T3p) directs the activity and localization of chromosomal passenger complex (CPC) and spindle assembly checkpoint (SAC) to regulate chromosome condensation and segregation in both mitosis and meiosis. However, the function of HASPIN kinase in the meiotic maturation of porcine oocytes is not yet known. Here, we found that HASPIN mRNA is constantly expressed in porcine oocyte maturation and subsequent early embryo development. Read More

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http://dx.doi.org/10.1530/REP-18-0447DOI Listing
March 2019
1 Read
3.174 Impact Factor

Mitochondria in early development: linking the microenvironment, metabolism and the epigenome.

Reproduction 2019 May;157(5):R159-R179

School of BioSciences, University of Melbourne, Parkville, Victoria, Australia.

Mitochondria, originally of bacterial origin, are highly dynamic organelles that have evolved a symbiotic relationship within eukaryotic cells. Mitochondria undergo dynamic, stage-specific restructuring and redistribution during oocyte maturation and preimplantation embryo development, necessary to support key developmental events. Mitochondria also fulfil a wide range of functions beyond ATP synthesis, including the production of intracellular reactive oxygen species and calcium regulation, and are active participants in the regulation of signal transduction pathways. Read More

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http://dx.doi.org/10.1530/REP-18-0431DOI Listing

Ram seminal plasma and its functional proteomic assessment.

Reproduction 2019 Mar 1. Epub 2019 Mar 1.

S de Graaf, Faculty of Science, The University of Sydney, The University of Sydney, 2006, Australia.

Ejaculation results in the confluence of epididymal spermatozoa with secretions of the accessory sex glands. This interaction is not a prerequisite for fertilisation success but seminal factors do play a crucial role in prolonging the survival of spermatozoa both in vitro and in vivo by affording protection from handling induced stress and some selective mechanisms of the female reproductive tract. Reproductive biologists have long sought to identify specific factors in seminal plasma that influence sperm function and fertility in these contexts. Read More

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http://dx.doi.org/10.1530/REP-18-0627DOI Listing

Anti-Müllerian hormone : a look back and ahead.

Authors:
Nathalie Josso

Reproduction 2019 Mar 1. Epub 2019 Mar 1.

N Josso, Unité 938, INSERM, Paris, France.

AMH is a member of the TGF-β family secreted by immature Sertoli cells and by the granulosa cells of growing ovarian follicles. In males, it induces the regression of fetal Müllerian ducts and represses androgen synthesis through receptors located on the Leydig cell membrane. In female mice, AMH inhibits primary follicle recruitment and sensitivity to FSH. Read More

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https://rep.bioscientifica.com/view/journals/rep/aop/rep-18-
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http://dx.doi.org/10.1530/REP-18-0602DOI Listing
March 2019
13 Reads

Mitochondria as a Biomarker for IVF Outcome.

Authors:
Julia Kim Emre Seli

Reproduction 2019 Mar 1. Epub 2019 Mar 1.

E Seli, Obstetrics, Gynecology, and Reproductive Sciences, Yale Univeristy School of Medicine, New Haven , 06520-8063, United States.

Mitochondria play an essential role in generating energy for embryo development and maintaining embryo metabolism through key cellular functions including ion homeostasis, amino acid metabolism, glycolysis, fatty acid metabolism, signal transduction, and apoptotic regulation. Recent literature suggests that mitochondrial content and function may be related to implantation success and embryo viability. Some studies have linked increased levels of mitochondrial DNA to aneuploidy, advanced maternal age, and euploid blastocyst with implantation failure, while others have failed to demonstrate similar findings. Read More

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http://dx.doi.org/10.1530/REP-18-0580DOI Listing
March 2019
1 Read

Testicular Transplantation for Fertility Preservation - Clinical Potential and Current Challenges.

Reproduction 2019 Mar 1. Epub 2019 Mar 1.

R Mitchell, MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom of Great Britain and Northern Ireland.

Transplantation of testicular tissues and cells has been proposed as a future clinical option for patients who have had testicular tissue cryopreserved prior to receiving gonadotoxic therapies. Whilst this approach remains experimental, success using animal models and successful transplantation of ovarian tissue resulting in live births in female patients provides optimism for the development of clinical applications involving transplantation of testicular tissue in males. Careful consideration must be given to patient groups that may benefit from this approach in the future. Read More

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http://dx.doi.org/10.1530/REP-18-0533DOI Listing
March 2019
1 Read

Unraveling the connection between GABA and Kisspeptin in the control of reproduction.

Reproduction 2019 Mar 1. Epub 2019 Mar 1.

V Lux-Lantos, Lab. de Neuroendocrinología, Instituto de Biología y Medicina Experimental (IByME) - CONICET, CABA, C1428ADN, Argentina.

Neuroendocrine control of reproduction involves the interplay of various factors that become active at some point along development. GnRH is the main neurohormone controlling reproduction and among the most important inputs modulating GnRH synthesis/secretion are GABA and kisspeptins. These interactions of GABA and kisspeptin in the control of GnRH secretion can take place by the presence of the receptors of both factors on the GnRH neuron or alternatively by the actions of GABA on kisspeptin neurons and/or the actions of kisspeptin on GABA neurons. Read More

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http://dx.doi.org/10.1530/REP-18-0527DOI Listing
March 2019
1 Read

Transcriptional status of mouse oocytes corresponds with their ability to generate Ca2+ release.

Reproduction 2019 Feb 1. Epub 2019 Feb 1.

A Ajduk, Department of Embryology, University of Warsaw, Warsaw, Poland.

In fully grown ovarian follicles both transcriptionally active (NSN) and inactive (SN) oocytes are present. NSN oocytes have been shown to display lower developmental potential. It is possible that oocytes that have not completed transcription before meiosis resumption accumulate less RNA and proteins required for their further development, including those responsible for regulation of Ca2+ homeostasis. Read More

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http://dx.doi.org/10.1530/REP-18-0625DOI Listing
February 2019

Glucose regulates the histone acetylation of gene promoters in decidualizing stromal cells.

Reproduction 2019 Feb 1. Epub 2019 Feb 1.

N Sugino, Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan.

Decidualization stimuli activate the insulin signaling pathway and increase the glucose uptake in human endometrial stromal cells (ESCs). The inductions of prolactin (PRL) and IGF-binding protein-1 (IGFBP1), specific markers of decidualization, were inhibited by incubating ESCs under low-glucose concentrations. These results suggested that decidualization stimuli activate the insulin signaling pathway, which contributes to decidualization through the increase of glucose uptake. Read More

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http://dx.doi.org/10.1530/REP-18-0393DOI Listing
February 2019
1 Read

VIP activates primordial follicles of rat through ERK-mTOR pathway during in tissue culture.

Reproduction 2019 Feb 1. Epub 2019 Feb 1.

Q Zhang, Department of Obstetrics and Gynaecology, IVF Centre, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

In vitro activation of primordial follicles is becoming more essential in assisted reproductive technologies. Vasoactive intestinal peptide (VIP) is one of the members of the neurotrophin family which has demonstrated to have an impact on follicle development in recent years. This study aims to investigate the effect of VIP on the activation of primordial follicles in neonatal rat in an in vitro culture system and to determine the relevant molecular mechanism of their activation. Read More

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https://rep.bioscientifica.com/view/journals/rep/aop/rep-18-
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http://dx.doi.org/10.1530/REP-18-0466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433003PMC
February 2019
20 Reads

C-type natriuretic peptide enhances mouse preantral follicle growth.

Reproduction 2019 Feb 1. Epub 2019 Feb 1.

J Tian, College of Animal Sciences and Technology, China Agricultural University, Beijing, China.

Compared to ovarian antral follicle development, the mechanism underlying preantral follicle growth has not been well documented. Although C-type natriuretic peptide (CNP) involvement in preantral folliculogenesis has been explored, its detailed role has not been fully defined. Here, we used mouse preantral follicles and granulosa cells (GCs) as a model for investigating the dynamic expression of CNP and natriuretic peptide receptor 2 (NPR2) during preantral folliculogenesis, the regulatory role of oocyte-derived growth factors (ODGFs) in natriuretic peptide type C (Nppc) and Npr2 expression, and the effect of CNP on preantral GC viability. Read More

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http://dx.doi.org/10.1530/REP-18-0470DOI Listing
February 2019

Inhibition of DNA repair protein RAD51 affects porcine preimplantation embryo development.

Reproduction 2019 03;157(3):223-234

Department of Animal Sciences, Chungbuk National University, Cheongju, Korea.

Homologous recombination (HR) plays a critical role in facilitating replication fork progression when the polymerase complex encounters a blocking DNA lesion, and it also serves as the primary mechanism for error-free DNA repair of double-stranded breaks. DNA repair protein RAD51 homolog 1 (RAD51) plays a central role in HR. However, the role of RAD51 during porcine early embryo development is unknown. Read More

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http://dx.doi.org/10.1530/REP-18-0271DOI Listing
March 2019
2 Reads

Gestational nutrition 1: alterations to gestational nutrition can increase indicators of fertility in sheep.

Reproduction 2019 03;157(3):199-213

Animal Science, AgResearch, Invermay Agricultural Centre, Mosgiel, New Zealand.

The aim of this study was to examine the relationships between gestational nutrition, fetal ovarian development and offspring fertility in female sheep and to highlight the potential mechanisms underlying these relationships. Adult sheep (n = 79) were fed either a maintenance or 0.6 of maintenance plane of nutrition for the first 55 days of gestation and thereafter fed ad libitum. Read More

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http://dx.doi.org/10.1530/REP-18-0357DOI Listing
March 2019
1 Read

Gastrointestinal capacity, gut hormones and appetite change during rat pregnancy and lactation.

Reproduction 2019 Feb 1. Epub 2019 Feb 1.

V Taylor, School of Life, Health and Chemical Sciences, The Open University, Milton Keynes, United Kingdom of Great Britain and Northern Ireland.

Pregnancy and lactation increase maternal appetite and adiposity, which in humans can lead to long-term body mass retention. Previous rat reproduction studies suggest that appetite-inhibiting gut hormone, peptide-YY (PYY), is elevated, despite hyperphagia; also that gastrointestinal size increases. The present study characterised changes in orexigenic (appetite-stimulating) ghrelin and anorexigenic (appetite-inhibiting) PYY and glucagon-like peptide-1 (GLP-1), and gastrointestinal architecture during pregnancy and lactation, in matched fed and fasted plasma and gut tissue samples taken during the dark phase. Read More

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http://dx.doi.org/10.1530/REP-18-0414DOI Listing
February 2019
2 Reads

Discovering Science and the Ovary: A Career of Joy.

Authors:
JoAnne Richards

Reproduction 2019 Feb 1. Epub 2019 Feb 1.

J Richards, Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.

My career has been about discovering science and learning the joys of the discovery process itself. It has been a challenging but rewarding process filled with many exciting moments and wonderful colleagues and students. Although I went to college to become a French major, I ultimately stumbled into research while pursuing a Masters Degree in teaching. Read More

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http://dx.doi.org/10.1530/REP-18-0513DOI Listing
February 2019

The contribution of epididymosomes to the sperm small RNA profile.

Reproduction 2019 Feb 1. Epub 2019 Feb 1.

B Nixon, School of Environmental and Life Sciences, The University of Newcastle, Priority Research Centre for Reproductive Science, Callaghan, Australia.

It is now well established that mature spermatozoa harbour a rich and diverse profile of small non-protein coding regulatory RNAs (sRNAs). There is also growing appreciation that this sRNA profile displays considerable plasticity, being altered in response to paternal exposure to a variety of environmental stressors. Coupled with evidence that upon delivery to the oocyte at the moment of fertilisation, sperm-borne sRNAs are able to influence both early embryonic development and the subsequent health of the offspring, there is now interest in both the timing and degree of change in the composition of the sRNA cargo of sperm. Read More

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http://dx.doi.org/10.1530/REP-18-0480DOI Listing
February 2019

H19 regulates trophoblastic spheroid adhesion by competitively binding to let-7.

Reproduction 2019 Feb 1. Epub 2019 Feb 1.

N Liu, reproductive center of medicine, Xiangya Hospital Central South University, Changsha, China.

Integrin β3 (ITGB3), which is the target gene of the miRNA let-7 that can be antagonized by long noncoding RNA (lncRNA) H19, is well-known to have a critical role in endometrium receptivity. However, the regulation of ITGB3 in cell-cell or cell-extracellular matrix adhesion and invasion for the maintenance of early pregnancy remains unknown. This study aimed to explore the role of the H19/let-7/ITGB3 axis in regulating trophoblastic spheroid adhesion and in vitro invasion ability using the HTR-8/SVneo cell line and to investigate the expression levels of lncRNA H19 and ITGB3 in human products of conception. Read More

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http://dx.doi.org/10.1530/REP-18-0339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433002PMC
February 2019
1 Read

Progesterone alters the bovine uterine fluid lipidome during the period of elongation.

Reproduction 2018 Apr;157(4):399-411

School of Agriculture and Food Science, University College Dublin, Belfield, Dublin 4, Ireland.

Successful bovine pregnancy establishment hinges on conceptus elongation, a key reproductive phenomenon coinciding with the period during which most pregnancies fail. Elongation is yet to be recapitulated in vitro, whereas in vivo it is directly driven by uterine secretions and indirectly influenced by prior circulating progesterone levels. To better understand the microenvironment evolved to facilitate this fundamental developmental event, uterine fluid was recovered on Days 12-14 of the oestrous cycle - the window of conceptus elongation initiation - from cycling heifers supplemented, or not, with progesterone. Read More

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http://dx.doi.org/10.1530/REP-18-0615DOI Listing
April 2018
1 Read

Cyclin-dependent kinase 21 is a novel regulator of proliferation and meiosis in the male germline of zebrafish.

Reproduction 2018 Apr;157(4):383-398

Biology Department, University of Massachusetts Boston, Boston, Massachusetts, USA.

Germ cell differentiation and maintenance relies on complex regulation of mitotic and meiotic progression. Cyclin-dependent kinases (CDKs) and their activating cyclin partners are known to have specialized roles in regulating cell cycle progression across tissues, including germ cells. Very little is known about CDK/cyclin function in zebrafish or the regulation of germ cell maintenance and differentiation. Read More

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http://dx.doi.org/10.1530/REP-18-0386DOI Listing

Serum and tissue pregnanes and pregnenes after dexamethasone treatment of cows in late gestation.

Reproduction 2019 Feb 1. Epub 2019 Feb 1.

L Reynolds, Department of Animal Sciences, North Dakota State University, Fargo, United States.

Dexamethasone (DEX) initiates parturition by inducing progesterone withdrawal and affecting placental steroidogenesis, but the effects of DEX in fetal and maternal tissue steroid synthetic capacity remains poorly investigated. Blood was collected from cows at 270 days of gestation before DEX or saline (SAL) treatment, and blood and tissues were collected at slaughter 38 hours later. Steroid concentrations were determined by liquid chromatography tandem mass spectrometry to detect multiple steroids including 5α-reduced pregnane metabolites of progesterone. Read More

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http://dx.doi.org/10.1530/REP-18-0558DOI Listing
February 2019

New insights of the role of β-NGF in the ovulation mechanism of induced ovulating species.

Reproduction 2019 Feb 1. Epub 2019 Feb 1.

G Adams, Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Canada.

The type of stimuli triggering GnRH secretion has been used to classify mammalian species into two categories: spontaneous or induced ovulators. In the former, ovarian steroids produced by a mature follicle elicit the release of GnRH from the hypothalamus, but in the latter, GnRH secretion requires coital stimulation. However, the mechanism responsible for eliciting the preovulatory LH surge in induced ovulators is still not well understood and seems to vary among species. Read More

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http://dx.doi.org/10.1530/REP-18-0305DOI Listing
February 2019

Notch activity mediates oestrogen-induced stromal cell invasion in endometriosis.

Reproduction 2018 Apr;157(4):371-381

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Oestrogen has been reported to control the invasiveness of endometrial stromal cells in endometriosis. Notch signalling, a master regulator of cell invasion in tumours, is regulated by oestrogen in other diseases and hyperactivated in endometriotic stromal cells. Therefore, we hypothesized that an interaction between Notch signalling and oestrogen may exist in the regulation of endometrial stromal cell invasion, which is essential for the development of endometriosis. Read More

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https://rep.bioscientifica.com/view/journals/rep/aop/rep-18-
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http://dx.doi.org/10.1530/REP-18-0326DOI Listing
April 2018
11 Reads
3.174 Impact Factor

DZNep and UNC0642 enhance in vitro developmental competence of cloned pig embryos.

Reproduction 2018 04;157(4):359-369

National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, China.

Somatic cell nuclear transfer in mammalian cloning suffers from a faulty epigenetic reprogramming, which is believed to cause developmental failures in cloned embryos. Regulating the epigenetic-modifying enzymes can rescue the chromatin of cloned embryos from aberrant epigenetic status, thereby potentially promoting cloning efficiency. In this study, we investigated the effect of two histone methyltransferase inhibitors, namely, DZNep and UNC0642, on the in vitro developmental competence of cloned pig embryos. Read More

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http://dx.doi.org/10.1530/REP-18-0571DOI Listing

Update on mammalian sperm capacitation: How much does the horse differ from other species?

Reproduction 2019 Feb 1. Epub 2019 Feb 1.

B Gadella, Faculty of Veterinary Medicine Department Bicohemistry and Cell Biology, Utrecht University, Utrecht, Netherlands.

In contrast to various other mammalian species, conventional in vitro fertilization (IVF) with horse gametes is not reliably successful. In particular, stallion spermatozoa fail to penetrate the zona pellucida, most likely due to incomplete activation of stallion spermatozoa (capacitation) under in vitro conditions. In other mammalian species, specific capacitation triggers have been described; unfortunately, none of these is able to induce full capacitation in stallion spermatozoa. Read More

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http://dx.doi.org/10.1530/REP-18-0541DOI Listing
February 2019
1 Read
3.174 Impact Factor

Ovarian stimulation for preimplantation genetic testing.

Reproduction 2019 04;157(4):R127-R142

Hospital Universitario Dexeus, Barcelona, Spain.

A narrative review of the management of controlled ovarian stimulation in patients undergoing preimplantation genetic testing is presented. An electronic search was performed to identify research publications that addressed ovarian stimulation and preimplantation genetic testing published until December 2017. Studies were classified in decreasing categories: randomized controlled trials, prospective controlled trials, prospective non-controlled trials, retrospective studies and experimental studies. Read More

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https://rep.bioscientifica.com/view/journals/rep/aop/rep-18-
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http://dx.doi.org/10.1530/REP-18-0475DOI Listing
April 2019
6 Reads

Do prenatal exposures pose a real threat to ovarian function? Bisphenol A as a case study.

Reproduction 2019 04;157(4):R143-R157

Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.

Fetal development represents a time of potential vulnerability due to rapid cell division, organ development and limited fetal kidney/liver activity for detoxification and metabolism of exposures. Health effects of prenatal toxicant exposure have previously been described, but there is little cohesive evidence surrounding effects on ovarian function. Using bisphenol A (BPA) as a case study, we seek to examine whether a prominent prenatal environmental exposure can pose a real threat to human ovarian function. Read More

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http://dx.doi.org/10.1530/REP-17-0734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450087PMC
April 2019
1 Read

Ejaculate-mediated paternal effects: evidence, mechanisms and evolutionary implications.

Reproduction 2019 04;157(4):R109-R126

Centre for Evolutionary Biology, School of Biological Sciences, University of Western Australia, Crawley, Western Australia, Australia.

Despite serving the primary objective of ensuring that at least one sperm cell reaches and fertilises an ovum, the male ejaculate (i.e. spermatozoa and seminal fluid) is a compositionally complex 'trait' that can respond phenotypically to subtle changes in conditions. Read More

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http://dx.doi.org/10.1530/REP-18-0524DOI Listing
April 2019
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Evidence that growth hormone can improve mitochondrial function in oocytes from aged mice.

Reproduction 2018 Apr;157(4):345-358

Department of Obstetrics and Gynecology, Characteristic Medical Center of PAP, Tianjin, People's Republic of China.

Decline in successful conception decreases more rapidly after 38 years of age owing to follicular depletion and decreased oocyte quality. However, limited information is available regarding the underlying mechanism and the useful treatment. This study aimed to evaluate the effects of growth hormone supplementation on oocyte maturation in vivo in aged and young mice and to determine its effect on mitochondrial function. Read More

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http://dx.doi.org/10.1530/REP-18-0529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420407PMC
April 2018
1 Read
3.174 Impact Factor