6,235 results match your criteria Reperfusion Injury in Stroke


Electroacupuncture Inhibits Neuronal Autophagy and Apoptosis the PI3K/AKT Pathway Following Ischemic Stroke.

Front Cell Neurosci 2020 15;14:134. Epub 2020 May 15.

Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang, China.

Electroacupuncture (EA) is a safe and effective therapy for ischemic stroke in both clinical and laboratory settings. However, the underlying mechanism behind EA treatment for stroke remains unclear. Here, we aimed to evaluate whether EA treatment at the acupoints of Zusanli (ST36) and Quchi (LI11) exerted a neuroprotective effect on ischemic stroke rats by modulating autophagy and apoptosis the PI3K/AKT/mTOR signaling pathway. Read More

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http://dx.doi.org/10.3389/fncel.2020.00134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242565PMC

Reduced Post-ischemic Brain Injury in Knockout Mice.

Front Neurosci 2020 12;14:453. Epub 2020 May 12.

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background And Purpose: In the acute phase of ischemia-reperfusion, hypoperfusion associated with ischemia and reperfusion in microvascular regions and disruption of the blood-brain barrier (BBB) contribute to post-ischemic brain injury. We aimed to clarify whether brain injury following transient middle cerebral artery occlusion (tMCAO) is ameliorated in knockout ( ) mice.

Methods: tMCAO was induced in wild-type (WT) and mice aged 8-10 weeks. Read More

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http://dx.doi.org/10.3389/fnins.2020.00453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235376PMC

Inhibition of IL-32 Expression Ameliorates Cerebral Ischemia-Reperfusion Injury via the NOD/MAPK/NF-κB Signaling Pathway.

J Mol Neurosci 2020 May 30. Epub 2020 May 30.

Neurology Department, Luoyang Central Hospital Affiliated to Zhengzhou University, 288 Zhongzhou Road, Luoyang City, Henan Province, China.

Cerebral ischemia represents a major cause of disability, yet its precise mechanism remains unknown. In addition, ischemia-reperfusion injury which occurs during the blood recovery process increases the risk of mortality, and is not adequately addressed with current treatment. To improve therapeutic options, it is important to explore the vital substances that play a pivotal role in ischemia-reperfusion injury. Read More

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http://dx.doi.org/10.1007/s12031-020-01557-0DOI Listing

Baicalin combats glutamate excitotoxicity via protecting glutamine synthetase from ROS-induced 20S proteasomal degradation.

Redox Biol 2020 May 16;34:101559. Epub 2020 May 16.

Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, China; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, China. Electronic address:

Background: Many neuroprotective approaches targeting neurons in animal models fail to provide benefits for the treatment of ischemic stroke in clinic and glial cells have become the targets in some basic studies. Baicalin has neuroprotective effects but the mechanisms related to glial cells are not revealed. This study investigated whether and how baicalin can combat excitotoxicity via protecting the functions of astrocytes in early stage of ischemia/reperfusion (I/R) insult by focusing on glutamine synthetase (GS). Read More

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http://dx.doi.org/10.1016/j.redox.2020.101559DOI Listing

Icariin protects neurons from endoplasmic reticulum stress-induced apoptosis after OGD/R injury via suppressing IRE1α-XBP1 signaling pathway.

Life Sci 2020 May 26:117847. Epub 2020 May 26.

Zhuhai Campus of Zunyi Medical University, Zhuhai, Guangdong 519041, China.

Icariin (ICA), a flavonol glycoside isolated from Epimedium, has been considered as a potential alternative therapy for ischemic stroke. However, the protective mechanisms of ICA on cerebral ischemia-reperfusion (I/R) are not fully illuminated yet. The effects of ICA on ER stress and inflammatory response which were involved in the pathological process of cerebral I/R were investigated in vitro. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117847DOI Listing

Protective effect of microRNA‑340‑5p against oxygen‑glucose deprivation/reperfusion in PC12 cells through targeting neuronal differentiation 4.

Mol Med Rep 2020 May 22. Epub 2020 May 22.

Department of Neurology, The Central Hospital of Wuhan, Wuhan, Hubei 430014, P.R. China.

The expression levels of microRNA (miR)‑340‑5p are reportedly decreased in the peripheral blood during acute ischemic stroke; however, the direct effect and mechanism of action of miR‑340‑5p in ischemic stroke remains largely unknown. The present study aimed to investigate the effects of miR‑340‑5p, and its mechanism of action, on PC12 cells following oxygen‑glucose deprivation/reperfusion (OGD/R) induction. OGD/R‑induced PC12 cells served as the cellular model and subsequently, mRNA expression levels of miR‑340‑5p and neuronal differentiation 4 (Neurod4) were analyzed using reverse transcription‑quantitative PCR. Read More

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http://dx.doi.org/10.3892/mmr.2020.11174DOI Listing

Triad3A displays a critical role in suppression of cerebral ischemic/reperfusion (I/R) injury by regulating necroptosis.

Biomed Pharmacother 2020 May 24;128:110045. Epub 2020 May 24.

Department of Neurology, Liaocheng People's Hospital, Liaocheng, Shandong, 252000, PR China. Electronic address:

Ischemic stroke is a major cause of death and disability worldwide. Necroptosis is known as a form of cell death, playing an essential role in regulating ischemia-induced brain injury. Triad3A is a ubiquitin ligase of the RING-in-between-RING family, and regulates necroptotic cell death under different pathological conditions, including neurodegenerative disorders. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110045DOI Listing

Lung injury in brain ischemia/reperfusion is exacerbated by mechanical ventilation with moderate tidal volume in rat.

Am J Physiol Regul Integr Comp Physiol 2020 May 27. Epub 2020 May 27.

Physiology, Shiraz University of Medical Sciences, Iran.

Introduction: Ischemic stroke is one of the most frequent causes of injury in the central nervous system which may lead to multi-organ dysfunction, including the lung. The aim of this study was to investigate whether brain ischemia/reperfusion with or without mechanical ventilation leads to lung injury.

Method: Male Sprague Dawley rats were assigned to 4 groups of Sham, 1-hour brain ischemia (MCAO)/24 hours reperfusion (I/R), mechanical ventilation with moderate tidal volume (MTV), and I/R+MTV. Read More

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http://dx.doi.org/10.1152/ajpregu.00367.2019DOI Listing

An Integrative Pharmacology-Based Analysis of Refined Qingkailing Injection Against Cerebral Ischemic Stroke: A Novel Combination of Baicalin, Geniposide, Cholic Acid, and Hyodeoxycholic Acid.

Front Pharmacol 2020 8;11:519. Epub 2020 May 8.

School of Traditional Chinese Medicine Department, Beijing University of Chinese Medicine, Beijing, China.

Stroke is the second leading cause of death after heart disease globally and cerebral ischemic stroke accounts for approximately 70% of all incident stroke cases. We selected four main compounds from a patent Chinese medicine, Qingkailing (QKL) injection, including baicalin from Georgi (Huang Qin), geniposide from J. Ellis (Zhizi), and cholic acid and hyodeoxycholic acid from (Niuhuang) with a ratio of 4. Read More

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http://dx.doi.org/10.3389/fphar.2020.00519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227481PMC

Platelets in Thrombo-Inflammation: Concepts, Mechanisms, and Therapeutic Strategies for Ischemic Stroke.

Hamostaseologie 2020 Jun 26;40(2):153-164. Epub 2020 May 26.

Institute of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany.

Platelets are anucleate cells known for their essential function in hemostasis and formation of thrombi under pathologic conditions. In recent years, strong evidence emerged demonstrating the critical involvement of platelets in inflammatory processes including acute ischemic stroke (AIS), which is one of the leading causes of death and disability worldwide. Recanalization of the occluded brain artery to reconstitute cerebral blood flow is the primary goal in the treatment of stroke patients. Read More

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http://dx.doi.org/10.1055/a-1151-9519DOI Listing

Farnesoid X receptor knockout protects brain against ischemic injury through reducing neuronal apoptosis in mice.

J Neuroinflammation 2020 May 25;17(1):164. Epub 2020 May 25.

School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua-Shan Road, Shanghai, 200030, China.

Background: Farnesoid X receptor (FXR) is a nuclear receptor that plays a critical role in controlling cell apoptosis in diverse diseases. Previous studies have shown that knocking out FXR improved cardiac function by reducing cardiomyocyte apoptosis in myocardial ischemic mice. However, the role of FXR after cerebral ischemia remains unknown. Read More

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http://dx.doi.org/10.1186/s12974-020-01838-wDOI Listing

Therapeutic treatment with vitamin C reduces focal cerebral ischemia-induced brain infarction in rats by attenuating disruptions of blood brain barrier and cerebral neuronal apoptosis.

Free Radic Biol Med 2020 May 23;155:29-36. Epub 2020 May 23.

Department of Food Science and Applied Biotechnology, National Chung-Hsing University, Taichung, Taiwan.

Stroke is a major public health problem and ranks third most common cause of death in adults worldwide. Thrombolysis with recombinant tissue plasminogen activator and endovascular thrombectomy are the main revascularization therapies for acute ischemic stroke. However, ischemia-reperfusion injury, mainly caused by oxidative/nitrosative stress injury, after revascularization therapy can result in worsening outcomes. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2020.05.015DOI Listing

Phoenixin 14 inhibits ischemia/reperfusion-induced cytotoxicity in microglia.

Arch Biochem Biophys 2020 May 22:108411. Epub 2020 May 22.

Department of Neurology, Liaocheng People's Hospital of Shandong First Medical University, Liaocheng City, Shandong Province, 252000, China. Electronic address:

The process of ischemia/reperfusion (IR) in ischemic stroke often leads to significant cell death and permanent neuronal damage. Safe and effective treatments are urgently needed to mitigate the damage caused by IR injury. The naturally occurring pleiotropic peptide phoenixin 14 (PNX-14) has recently come to light as a potential treatment for IR injury. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108411DOI Listing

PAQR3 protects against oxygen-glucose deprivation/reperfusion-induced injury through the ERK signaling pathway in N2A cells.

J Mol Histol 2020 Jun 25;51(3):307-315. Epub 2020 May 25.

Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Cerebral ischemia-reperfusion injury is pivotal in the development of multiple-subcellular organelle and tissue injury after acute ischemic stroke. Recently, the Golgi apparatus (GA) has been shown to be a key subcellular organelle that plays an important role in neuroprotection against oxygen-glucose deprivation/reperfusion (OGD/R) injury. PAQR3, a scaffold protein exclusively localized in the GA, was originally discovered as a potential tumor suppressor protein. Read More

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http://dx.doi.org/10.1007/s10735-020-09881-wDOI Listing

Histone Deacetylase Inhibitors: A Novel Strategy for Neuroprotection and Cardioprotection Following Ischemia/Reperfusion Injury.

J Am Heart Assoc 2020 May 22:e016349. Epub 2020 May 22.

Department of Emergency Medicine Michigan Medicine University of Michigan Ann Arbor MI.

Ischemia/reperfusion injury is a complex molecular cascade that causes deleterious cellular damage and organ dysfunction. Stroke, sudden cardiac arrest, and acute myocardial infarction are the most common causes of ischemia/reperfusion injury without effective pharmacologic therapies. Existing preclinical evidence suggests that histone deacetylase inhibitors may be an efficacious, affordable, and clinically feasible therapy that can improve neurologic and cardiac outcomes following ischemia/reperfusion injury. Read More

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http://dx.doi.org/10.1161/JAHA.120.016349DOI Listing

Idebenone attenuates cerebral inflammatory injury in ischemia and reperfusion via dampening NLRP3 inflammasome activity.

Mol Immunol 2020 May 18;123:74-87. Epub 2020 May 18.

Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

Background: Idebenone is a well-appreciated mitochondrial protectant while the mechanisms underlying the neuroprotection in cerebral ischemia and reperfusion (I/R) remain elusive. It has been manifested NLRP3 inflammasom activation contributed to I/R induced damage. It raises questions how exactly NLRP3 inflammasom was activated in microglia and neuron and whether idebenone reverses the process in I/R. Read More

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http://dx.doi.org/10.1016/j.molimm.2020.04.013DOI Listing

Therapeutic mechanism of human neural stem cell-derived extracellular vesicles against hypoxia-reperfusion injury in vitro.

Life Sci 2020 May 11;254:117772. Epub 2020 May 11.

Key Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhuaxi Road, Jinan 250012, China. Electronic address:

Aims: This study aimed to explore that the human neural stem cell derived extracellular vesicles (hNSC-EVs) have therapeutic effect on neuronal hypoxia-reperfusion (H/R) injured neurons in vitro by mediating the nuclear translocation of NF-E2-related factor 2 (Nrf2) to regulate the expression of downstream oxidative kinases.

Main Methods: The neuroprotective effects of hNSC-EVs were evaluated in an in vitro neuronal H/R model. Three parameters of hNSC-EVs, structure, phenotype and particle size, were characterized. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117772DOI Listing

Empagliflozin alleviates neuronal apoptosis induced by cerebral ischemia/reperfusion injury through HIF-1α/VEGF signaling pathway.

Arch Pharm Res 2020 May 20. Epub 2020 May 20.

Department of Pharmacology, Faculty of Medicine, Minia University, El-Minia, Egypt.

Ischemic stroke is a serious condition associated with severe functional disability and high mortality, however; effective therapy remains elusive. Empagliflozin, a sodium-glucose cotransporter 2 inhibitor, has been shown to exert additional non-glycemic benefits including anti-apoptotic effects in different disease settings. Thereby, this study was designed to investigate the ameliorative effect of empagliflozin on the neuronal apoptosis exhibited in cerebral ischemia/reperfusion (I/R) in a rat model targeting HIF-1α/VEGF signaling which is involved in this insult. Read More

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http://dx.doi.org/10.1007/s12272-020-01237-yDOI Listing

Therapeutic strategies for ischemia reperfusion injury in emergency medicine.

Acute Med Surg 2020 Jan-Dec;7(1):e501. Epub 2020 Apr 13.

Department of Emergency, Critical Care and Disaster Medicine Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan.

Ischemia reperfusion (IR) injury occurs when blood supply, perfusion, and concomitant reoxygenation is restored to an organ or area following an initial poor blood supply after a critical time period. Ischemia reperfusion injury contributes to mortality and morbidity in many pathological conditions in emergency medicine clinical practice, including trauma, ischemic stroke, myocardial infarction, and post-cardiac arrest syndrome. The process of IR is multifactorial, and its pathogenesis involves several mechanisms. Read More

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http://dx.doi.org/10.1002/ams2.501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231568PMC

Disulfide-HMGB1 Drives Ischemia-Reperfusion Injury in Human Liver Transplantation.

Hepatology 2020 May 19. Epub 2020 May 19.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.

Background & Aims: Sterile inflammation is a major clinical concern during ischemia-reperfusion injury (IRI) triggered by traumatic events including stroke, myocardial infarction, and solid organ transplantation. Despite HMGB1 clearly being involved in sterile inflammation, its role is controversial due to a paucity of patient-focused research.

Approach & Results: Here, we examined the role of HMGB1 oxidation states in human IRI following liver transplantation. Read More

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http://dx.doi.org/10.1002/hep.31324DOI Listing

N-methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury.

Ther Adv Chronic Dis 2020 29;11:2040622320916024. Epub 2020 Apr 29.

Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China Wencheng County People's Hospital, Wenzhou, Zhejiang, China.

Background: Although N-methyladenosine (mA) plays a very important role in different biological processes, its function in the brain has not been fully explored. Thus, we investigated the roles of the RNA demethylases Alkbh5/Fto in cerebral ischemia-reperfusion injury.

Methods: We used a rat model and primary neuronal cell culture to study the role of mA and Alkbh5/Fto in the cerebral cortex ischemic penumbra after cerebral ischemia-reperfusion injury. Read More

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http://dx.doi.org/10.1177/2040622320916024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222229PMC

Expression of Long Non-coding RNA RGD1566344 in the Brain Cortex of Male Mice After Focal Cerebral Ischemia-Reperfusion and the Neuroprotective Effect of a Non-coding RNA RGD1566344 Inhibitor.

Cell Mol Neurobiol 2020 May 18. Epub 2020 May 18.

Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, The Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer of the State Administration of Traditional Chinese Medicine, Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225001, People's Republic of China.

Ischemic stroke (IS) remains a major cause of disability and death. The changes in long non-coding RNA (lncRNA) RGD1566344 expression in the mouse cerebral cortex, including the infarct and penumbra regions after IS, are not clear. Less is known about the impact and underlying mechanisms of RGD1566344 in IS. Read More

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http://dx.doi.org/10.1007/s10571-020-00877-4DOI Listing

Cerebral Ischemia-Reperfusion Injury: Lysophosphatidic Acid Mediates Inflammation by Decreasing the Expression of Liver X Receptor.

J Mol Neurosci 2020 May 18. Epub 2020 May 18.

Department of Neurology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, HanZheng Street 473# QiaoKou District, Wuhan, 430033, China.

Lysophosphatidic acid (LPA), a ubiquitous phospholipid, plays a crucial role in the pathogenesis and pathophysiological process of neurological diseases, which constitute the pathological course after cerebral ischemia. Nevertheless, the molecular mechanisms associated with the pathogenic roles of LPA remain elusive. In this study, we evaluated the expression of the liver X receptor (LXR) and nuclear factor kappa B (NFκB) by Western blotting, quantified the levels of IL-1β, IL-6, TNF-α, and LPA by ELISA, and evaluated apoptosis and infarct by TUNEL (terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling) and TTC (triphenyltetrazolium chloride) staining respectively in Sprague-Dawley (SD) rats after middle cerebral artery occlusion (MCAO). Read More

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http://dx.doi.org/10.1007/s12031-020-01554-3DOI Listing

Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke.

J Clin Med 2020 May 14;9(5). Epub 2020 May 14.

Department of Neurology, Keimyung University School of Medicine, Daegu 42601, Korea.

Acute kidney injury (AKI) is often associated with the use of contrast agents. We evaluated the frequency of AKI, factors associated with AKI after endovascular treatment (EVT), and associations with AKI and clinical outcomes. We retrospectively analyzed consecutively enrolled patients with acute ischemic stroke who underwent EVT at three stroke centers in Korea. Read More

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http://dx.doi.org/10.3390/jcm9051471DOI Listing

Baicalein exerts neuroprotective effect against ischaemic/reperfusion injury via alteration of NF-kB and LOX and AMPK/Nrf2 pathway.

Inflammopharmacology 2020 May 16. Epub 2020 May 16.

Neurosurgery, Affiliated Hospital of Hebei University, Baoding, 071000, Hebei, China.

ischaemic stroke accounts for almost 11% of all deaths worldwide and has a high incidence of permanent disability among patients. Baicalein has many beneficial pharmacological properties, including anti-inflammatory and anti-oxidant effects. However, the neuroprotective effect of baicalein is still unclear. Read More

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http://dx.doi.org/10.1007/s10787-020-00714-6DOI Listing

Shuxuening injection facilitates neurofunctional recovery via down-regulation of G-CSF-mediated granulocyte adhesion and diapedesis pathway in a subacute stroke mouse model.

Biomed Pharmacother 2020 May 14;127:110213. Epub 2020 May 14.

State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Beihua South Road, JingHai District, Tianjin, 301617, China; Research and Development Center of TCM, Tianjin International Joint Academy of Biotechnology & Medicine, 220 Dongting Road, TEDA, Tianjin, 300457, China. Electronic address:

Post-stroke neural damage is a serious health concern which does not yet have an effective treatment. We have shown previously that Shuxuening injection (SXNI), a Ginkgo biloba extract-based natural medicine, protects brain after an acute ischemic stroke, but its efficacy for post-stroke recovery is not known. This study was to investigate whether SXNI can improve the prognosis of stroke at a subacute phase. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110213DOI Listing

Effects of protective controlled coronary reperfusion on left ventricular remodeling in dogs with acute myocardial infarction: A pilot study.

Cardiovasc Revasc Med 2020 May 6. Epub 2020 May 6.

InVatin Technologies, Ltd., Kazrin, Israel; Applicative Cardiovascular Research Center (ACRC) and Department of Cardiology, Meir Medical Center, Kfar Saba, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Background: Coronary artery obstruction causes ischemia of cardiac tissue, leading to acute myocardial infarction (AMI). The treatment of choice for reducing acute myocardial ischemic injury is early, effective vascular reperfusion using thrombolytic therapy or primary percutaneous coronary intervention. However, reperfusion can cause cardiomyocyte injury. Read More

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http://dx.doi.org/10.1016/j.carrev.2020.05.001DOI Listing

Compound K inhibits autophagy-mediated apoptosis induced by oxygen and glucose deprivation/reperfusion via regulating AMPK-mTOR pathway in neurons.

Life Sci 2020 May 19;254:117793. Epub 2020 May 19.

Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin, China; Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Changchun University of Chinese Medicine, Changchun, Jilin, China; Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China. Electronic address:

Aims: Oxygen and glucose deprivation and reperfusion (OGD/R) injury contributes to the pathophysiology after ischemic stroke, which needs to urgently develop treatment strategies. Previous studies have demonstrated that autophagy in reperfusion period exerted adverse effects on the cerebral ischemic injury. Ginsenoside monomer compound K (CK) is the main intestinal metabolite of ginseng that exerts the pharmacological activities and has a protective effect against cerebral OGD/R injury. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117793DOI Listing

α7nAchR mediates transcutaneous auricular vagus nerve stimulation-induced neuroprotection in a rat model of ischemic stroke by enhancing axonal plasticity.

Neurosci Lett 2020 May 19;730:135031. Epub 2020 May 19.

Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Axonal plasticity is important for neurofunctional recovery after stroke. This study aimed to explore the role of transcutaneous auricular vagus nerve stimulation (ta-VNS) on axonal plasticity and its underlying association with the α7 nicotinic acetylcholine receptor(α7nAchR) after cerebral ischemia/reperfusion (I/R) injury. Adult male Sprague-Dawley rats were pretreated by intraperitoneal injection with either phosphate-buffered saline (PBS) or an α7nAchR antagonist and then subjected to middle cerebral artery occlusion and ta-VNS treatment. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135031DOI Listing

CU06-1004 (endothelial dysfunction blocker) ameliorates astrocyte end-feet swelling by stabilizing endothelial cell junctions in cerebral ischemia/reperfusion injury.

J Mol Med (Berl) 2020 May 16. Epub 2020 May 16.

Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Cerebral ischemia, or stroke, is widespread leading cause of death and disability. Surgical and pharmacological interventions that recover blood flow are the most effective treatment strategies for stroke patients. However, restoring the blood supply is accompanied by severe reperfusion injury, with edema and astrocyte end-feet disruption. Read More

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http://dx.doi.org/10.1007/s00109-020-01920-zDOI Listing

Update on cerebral hyperperfusion syndrome.

J Neurointerv Surg 2020 May 15. Epub 2020 May 15.

Radiology, National Taiwan University, Taipei, Taiwan

Cerebral hyperperfusion syndrome (CHS) is a clinical syndrome following a revascularization procedure. In the past decade, neurointerventional surgery has become a standard procedure to treat stenotic or occluded cerebral vessels in both acute and chronic settings, as well as endovascular thrombectomy in acute ischemic stroke. This review aims to summarize relevant recent studies regarding the epidemiology, diagnosis, and management of CHS as well as to highlight areas of uncertainty. Read More

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http://dx.doi.org/10.1136/neurintsurg-2019-015621DOI Listing

Astilbin protects against cerebral ischaemia/reperfusion injury by inhibiting cellular apoptosis and ROS-NLRP3 inflammasome axis activation.

Int Immunopharmacol 2020 May 6;84:106571. Epub 2020 May 6.

Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China; Modern Medical Research Center, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China. Electronic address:

Background: Ischaemic stroke is a lethal cerebrovascular disease that occurs worldwide. Astilbin is a natural flavonoid compound with various physiological activities. The purpose of this study was to investigate the neuroprotective effects of Astilbin after cerebral ischaemia reperfusion (I/R) injury. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106571DOI Listing

Salvianolic Acid D Alleviates Cerebral Ischemia-Reperfusion Injury by Suppressing the Cytoplasmic Translocation and Release of HMGB1-Triggered NF-B Activation to Inhibit Inflammatory Response.

Mediators Inflamm 2020 22;2020:9049614. Epub 2020 Jan 22.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Inflammatory response participates in the overall pathophysiological process of stroke. It is a promising strategy to develop antistroke drugs targeting inflammation. This study is aimed at investigating the therapeutic effect and anti-inflammatory mechanism of salvianolic acid D (SalD) against cerebral ischemia/reperfusion (I/R) injury. Read More

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http://dx.doi.org/10.1155/2020/9049614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204335PMC
January 2020

Therapeutic targets of oxidative/nitrosative stress and neuroinflammation in ischemic stroke: Applications for natural product efficacy with omics and systemic biology.

Pharmacol Res 2020 May 12;158:104877. Epub 2020 May 12.

School of Chinese Medicine, The University of Hong Kong, Hong Kong Special Administrative Region; The University of Hong Kong-Shenzhen Institute of Research and Innovation (HKU-SIRI), China; School of Medical Technology, Xuzhou Medical University, Xuzhou, 221002, China. Electronic address:

Oxidative/nitrosative stress and neuroinflammation are critical pathological processes in cerebral ischemia-reperfusion injury, and their intimate interactions mediate neuronal damage, blood-brain barrier (BBB) damage and hemorrhagic transformation (HT) during ischemic stroke. We review current progress towards understanding the interactions of oxidative/nitrosative stress and inflammatory responses in ischemic brain injury. The interactions between reactive oxygen species (ROS)/reactive nitrogen species (RNS) and innate immune receptors such as TLR2/4, NOD-like receptor, RAGE, and scavenger receptors are crucial pathological mechanisms that amplify brain damage during cerebral ischemic injury. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.104877DOI Listing

Modulatory effect of 17β-estradiol on myeloid cell infiltration into the male rat brain after ischemic stroke.

J Steroid Biochem Mol Biol 2020 May 11:105667. Epub 2020 May 11.

University Clinic, Institute of Neuroanatomy, RWTH Aachen University, Germany. Electronic address:

Ischemic stroke is the leading cause of human disability and mortality in the world. Neuroinflammation is the main pathological event following ischemia which contributes to secondary brain tissue damage which is driven by infiltration of circulating immune cells such as macrophages. Because of neuroprotective properties against ischemic brain damage, estrogens have the potential to become of therapeutic interest. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2020.105667DOI Listing

No evidence of cardiac stunning or decoupling immediately after cardiopulmonary bypass for elective coronary surgery.

Acta Anaesthesiol Scand 2020 May 14. Epub 2020 May 14.

Department of Anesthesia and Intensive Care, St Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.

Background: There is significant uncertainty regarding the timing of onset of cardiovascular stunning after cardiac surgery. Cardiovascular stunning is affecting both contractility (Ees) and arterial load. Arterial load may be represented by arterial elastance (Ea) and participates in ventriculo-arterial coupling through the Ea/Ees ratio, giving information on efficiency and performance. Read More

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http://dx.doi.org/10.1111/aas.13621DOI Listing

Icariside II, a PDE5 Inhibitor, Suppresses Oxygen-Glucose Deprivation/Reperfusion-Induced Primary Hippocampal Neuronal Death Through Activating the PKG/CREB/BDNF/TrkB Signaling Pathway.

Front Pharmacol 2020 24;11:523. Epub 2020 Apr 24.

Department of Clinical Pharmacotherapeutics, School of Pharmacy, Zunyi Medical University, Zunyi, China.

Background: Ischemic stroke remains the leading cause of death and adult disability. Cerebral ischemic/reperfusion (I/R) injury is caused by ischemic stroke thereafter aggravates overwhelming neuronal apoptosis and even the death of neurons. Of note, hippocampus is more susceptive to cerebral I/R injury than the other brain region. Read More

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http://dx.doi.org/10.3389/fphar.2020.00523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194126PMC

rLj-RGD4, the shortened peptide of rLj-RGD3 from Lampetra japonica, protects against cerebral ischemia/reperfusion injury via the PI3K/Akt pathway.

Peptides 2020 May 7;129:170310. Epub 2020 May 7.

Department of Pharmacology, Dalian Medical University, Dalian, Liaoning Province, 116044, China. Electronic address:

The toxic RGD peptide, rLj-RGD4, characterized by 4 (Arg-Gly-Asp) (RGD) motifs, is a novel mutant of rLj-RGD3 from the salivary gland of Lampetra japonica. Our previous study showd that rLj-RGD3 exerts a protective effect against cerebral ischemia injury in rats. Through the induction of middle cerebral artery occlusion/reperfusion (MCAO) injuries in rats, the present study investigated the effects and the mechanism through which rLj-RGD4 protects against ischemic stroke. Read More

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http://dx.doi.org/10.1016/j.peptides.2020.170310DOI Listing

CD4 T Cell Responses Mediate Progressive Neurodegeneration in Experimental Ischemic Retinopathy.

Am J Pathol 2020 May 7. Epub 2020 May 7.

Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. Electronic address:

Retinal ischemic events as a result of occlusion of the ocular vasculature share similar etiologies of central nervous system (CNS) stroke and are among the most common cause of acute and irreversible vision loss in elderly patients. Currently, there is no established treatment, and the condition often leaves patients with seriously impaired vision or blindness. The immune system, particularly T cell-mediated responses, is thought to be intricately involved, but their exact roles remain elusive. Read More

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http://dx.doi.org/10.1016/j.ajpath.2020.04.011DOI Listing

Microglial-specific depletion of TAK1 is neuroprotective in the acute phase after ischemic stroke.

J Mol Med (Berl) 2020 May 7. Epub 2020 May 7.

Department of Neurology, RWTH Aachen University, Pauwelsstraße 30, D-52074, Aachen, Germany.

Transforming growth factor-β-activated kinase 1 (TAK1) is upregulated after cerebral ischemia and contributes to an aggravation of brain injury. TAK1 acts as a key regulator of NF-ΚB and the MAP kinases JNK and p38 and modulates post-ischemic neuroinflammation and apoptosis. Microglia are the main TAK1-expressing immunocompetent cells of the brain. Read More

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http://dx.doi.org/10.1007/s00109-020-01916-9DOI Listing

Kaempferol Protects Cell Damage in In Vitro Ischemia Reperfusion Model in Rat Neuronal PC12 Cells.

Biomed Res Int 2020 23;2020:2461079. Epub 2020 Apr 23.

School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China.

Ischemic cerebral stroke is a severe neurodegenerative disease with high mortality. Ischemia and reperfusion injury plays a fundamental role in ischemic cerebral stroke. To date, the strategy for ischemic cerebral stroke treatment is limited. Read More

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http://dx.doi.org/10.1155/2020/2461079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196139PMC

TET3 regulates DNA hydroxymethylation of neuroprotective genes following focal ischemia.

J Cereb Blood Flow Metab 2020 May 7:271678X20912965. Epub 2020 May 7.

Department of Neurological Surgery, University of Wisconsin-Madison, Madison, WI, USA.

The 5-hydroxymethylcytosine (5hmC) epigenetic modification is highly enriched in the CNS and a critical modulator of neuronal function and development. We found that cortical 5hmC was enhanced from 5 min to three days of reperfusion following focal ischemia in adult mice. Blockade of the 5hmC-producing enzyme ten-eleven translocase 3 (TET3) increased edema, infarct volume, and motor function impairments. Read More

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http://dx.doi.org/10.1177/0271678X20912965DOI Listing

miR-18b attenuates cerebral ischemia/reperfusion injury through regulation of ANXA3 and PI3K/Akt signaling pathway.

Brain Res Bull 2020 May 5;161:55-64. Epub 2020 May 5.

Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan, China. Electronic address:

Recent, research has displayed that the disorders of miR-18b are related to ischemic stroke. Here, we aimed to investigate the underlying neuroprotective mechanism of miR-18b in cerebral ischemia/reperfusion (I/R) injury. Oxygen-glucose deprivation/reperfusion (OGDR) model in vitro and middle cerebral artery occlusion (MCAO) model in vivo were established to simulate cerebral I/R injury. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2020.04.021DOI Listing

Artesunate promotes the proliferation of neural stem/progenitor cells and alleviates Ischemia-reperfusion Injury through PI3K/Akt/FOXO-3a/p27 signaling pathway.

Aging (Albany NY) 2020 May 7;12(9):8029-8048. Epub 2020 May 7.

Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, The Third Military Medical University (Army Military Medical University), Chongqing, China.

Stroke is one of the leading causes of death worldwide that also result in long-term disability. Endogenous neural stem/progenitor cells (NSPCs) within subventricular (SVZ) and dentate gyrus (DG) zone, stimulated by cerebral infarction, can promote neural function recovery. However, the proliferation of eNSPCs triggered by ischemia is not enough to induce neural repair, which may contribute to the permanent disability in stroke patients. Read More

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http://dx.doi.org/10.18632/aging.103121DOI Listing
May 2020
6.432 Impact Factor

High-frequency repetitive transcranial magnetic stimulation improves functional recovery by inhibiting neurotoxic polarization of astrocytes in ischemic rats.

J Neuroinflammation 2020 May 6;17(1):150. Epub 2020 May 6.

Department of Neurology, Jingling Hospital, Nanjing University School of Medicine, 305# East Zhongshan Road, Nanjing, 210002, Jiangsu, China.

Background: Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive treatment for ischemic stroke. Astrocytes regulation has been suggested as one mechanism for rTMS effectiveness. But how rTMS regulates astrocytes remains largely undetermined. Read More

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http://dx.doi.org/10.1186/s12974-020-01747-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203826PMC

Shared Genomic and Proteomic Contribution of Amyloid and Tau Protein Characteristic of Alzheimer's Disease to Brain Ischemia.

Int J Mol Sci 2020 Apr 30;21(9). Epub 2020 Apr 30.

Department of Pathophysiology, Medical University of Lublin, 20-090 Lublin, Poland.

Post-ischemic brain damage is associated with the deposition of folding proteins such as the amyloid and tau protein in the intra- and extracellular spaces of brain tissue. In this review, we summarize the protein changes associated with Alzheimer's disease and their gene expression (amyloid protein precursor and tau protein) after ischemia-reperfusion brain injury and their role in the post-ischemic injury. Recent advances in understanding the post-ischemic neuropathology have revealed dysregulation of and genes after ischemic brain injury. Read More

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http://dx.doi.org/10.3390/ijms21093186DOI Listing

Improvement of cerebral ischemia/reperfusion injury by daucosterol palmitate-induced neuronal apoptosis inhibition via PI3K/Akt/mTOR signaling pathway.

Metab Brain Dis 2020 May 4. Epub 2020 May 4.

Department of Surgery, Tumour Hospital of Liaocheng, Liaocheng city, 252000, Shandong, China.

Traditional Chinese medicine has growing importance in the treatment of ischemia stroke due to its abundance and low drug resistance. In this study, we aim to investigate the therapeutic potential of daucosterol palmitate against ischemia stroke, as well as its neuro-protective mechanism. The dose-response effects of daucosterol palmitate in the protection from brain damage were evaluated in a cerebral ischemia/reperfusion (I/R) rat model. Read More

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http://dx.doi.org/10.1007/s11011-020-00575-6DOI Listing

Geniposide inhibits NLRP3 inflammasome activation via autophagy in BV-2 microglial cells exposed to oxygen-glucose deprivation/reoxygenation.

Int Immunopharmacol 2020 Apr 30;84:106547. Epub 2020 Apr 30.

Central Laboratory, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China. Electronic address:

The nod-like receptor protein 3 (NLRP3) inflammasome has a critical role in cerebral ischemia. Autophagy may cause microglial inflammatory response or stimulate microglial function. The evidences clarify a direct crosstalk between autophagy and NLRP3. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106547DOI Listing

Protection of the Geum japonicum Thunb. var. chinense extracts against oxygen-glucose deprivation and re-oxygenation induced astrocytes injury via BDNF/PI3K/Akt/CREB pathway.

Biomed Pharmacother 2020 Apr 28;127:110123. Epub 2020 Apr 28.

Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, Medical College of China Three Gorges University, Yichang, 443002, China. Electronic address:

Geum japonicum Tunb. var. chinense (GJ) is a traditional Chinese medicine usually used for the alleviation of dizziness and headache. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110123DOI Listing

Computed tomography (CT) imaging evaluation of integrated traditional Chinese medicine cooperative therapy in treating acute cerebral infarction: A randomized controlled trial.

Medicine (Baltimore) 2020 May;99(18):e19998

Department of Radiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.

Introduction: Acute cerebral infarction is a clinically common cerebrovascular disease. Acute cerebral infarction is characterized by sudden onset, dangerous illness, high risk of death, and disability. Computed tomography perfusion imaging can detect abnormal brain tissue perfusion 30 minutes after the onset of cerebral ischemia, providing the earliest and most valuable information for clinical diagnosis and treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000019998DOI Listing