5,642 results match your criteria Reperfusion Injury in Stroke


Identification of key transcription factors associated with cerebral ischemia‑reperfusion injury based on gene‑set enrichment analysis.

Int J Mol Med 2019 Jun 9;43(6):2429-2439. Epub 2019 Apr 9.

Department of Vascular Neurosurgery, New Era Stroke Care and Research Institute, The PLA Rocket Force Characteristic Medical Center, Beijing 100088, P.R. China.

Cerebral ischemia‑reperfusion injury (CIRI) usually causes detrimental complications following reperfusion therapy in stroke patients. The present study systematically investigated the regulatory mechanism involved in the pathogenesis of CIRI using gene set enrichment analysis of the transient middle cerebral artery occlusion mouse stroke model. The results revealed a total of 13 CIRI‑related transcription factors (TFs), including CCAAT enhancer binding protein b (Cebpb), Cebpa, early growth response‑1, Fos, Rela, Jund, signal transduction and activator of transcription 5a/b, transformation related protein 53, GLI family zinc finger 2 (Gli2), Sp3, TF AP‑2 α (Tfap2a) and spleen focus forming virus proviral integration oncogene (Spi1). Read More

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http://dx.doi.org/10.3892/ijmm.2019.4159DOI Listing

Theophylline as an add-on to thrombolytic therapy in acute ischaemic stroke (TEA-Stroke): A randomized, double-blinded, placebo-controlled, two-centre phase II study.

Eur Stroke J 2016 Dec 14;1(4):248-254. Epub 2016 Oct 14.

Department of Neurology, Aalborg University Hospital, Aalborg, Denmark.

Introduction: Early reperfusion of brain tissue at risk of injury (penumbra salvage) is crucial in treating acute ischaemic stroke. Neuroprotective agents may extend the time window for the reperfusion. The vasoactive agent theophylline redistributes the perfusion to ischaemic brain tissue and thus reduces brain damage, brain tissue oedema and mortality in animal stroke models. Read More

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http://dx.doi.org/10.1177/2396987316674542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301252PMC
December 2016

ORAI1/STIM1 Interaction Intervenes in Stroke and in Neuroprotection Induced by Ischemic Preconditioning Through Store-Operated Calcium Entry.

Stroke 2019 May;50(5):1240-1249

IRCCS SDN, Naples, Italy (L.A.).

Background and Purpose- Disturbance of endoplasmic reticulum (ER) Ca homeostasis causes neuronal cell injury in stroke. By contrast, ischemic preconditioning (IPC)-a brief sublethal ischemic episode affording tolerance to a subsequent ischemic insult-restores ER Ca homeostasis. Under physiological conditions, ER calcium content is continuously refilled by the interaction between the ER-located Ca sensor STIM (stromal interacting molecule) 1 and the plasma membrane channel ORAI1 (a structural component of the CRAC calcium channel)-2 key mediators of the store-operated calcium entry (SOCE) mechanism. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.024115DOI Listing

Yangyin Tongnao granules enhance neurogenesis in the peri-infarct area and upregulate brain-derived neurotrophic factor and vascular endothelial growth factor after focal cerebral ischemic infarction in rats.

Mol Biol Rep 2019 Apr 20. Epub 2019 Apr 20.

Zhejiang Chinese Medical University, Hangzhou, 310053, China.

Yangyin Tongnao granules (YYTNG) have been extensively applied in the treatment of brain injury, mainly due to its antioxidant effects, inhibition of apoptosis, and enhancement of blood circulation. To analyze the effect of YYTNG on the recovery of neurological function and neurogenesis in the peri-infarct area after cerebral ischemic infarction in rats and to elucidate its role in the neuroprotective mechanism of stroke, Sprague-Dawley (SD) rats were subjected to middle cerebral artery occlusion (MCAO) for 90 min followed by reperfusion. Rats were randomly divided into five groups: sham, MCAO, and YYTNG-treated rats given doses of 0. Read More

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http://dx.doi.org/10.1007/s11033-019-04824-5DOI Listing

Inhibition of sodium-glucose cotransporter-2 preserves cardiac function during regional myocardial ischemia independent of alterations in myocardial substrate utilization.

Basic Res Cardiol 2019 Apr 19;114(3):25. Epub 2019 Apr 19.

Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN, 46202, USA.

The goal of the present study was to evaluate the effects of SGLT2i on cardiac contractile function, substrate utilization, and efficiency before and during regional myocardial ischemia/reperfusion injury in normal, metabolically healthy swine. Lean swine received placebo or canagliflozin (300 mg PO) 24 h prior to and the morning of an invasive physiologic study protocol. Hemodynamic and cardiac function measurements were obtained at baseline, during a 30-min complete occlusion of the circumflex coronary artery, and during a 2-h reperfusion period. Read More

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http://link.springer.com/10.1007/s00395-019-0733-2
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http://dx.doi.org/10.1007/s00395-019-0733-2DOI Listing
April 2019
1 Read

NLRP3 inflammasome activates interleukin-23/interleukin-17 axis during ischaemia-reperfusion injury in cerebral ischaemia in mice.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Department of Neurology, The First Affiliated Hospital of Harbin Medical University, China. Electronic address:

Aims: NLRP3 inflammasome has been reported associated with some inflammatory and autoimmune diseases. We previously researches showed that interleukin-23 (IL-23) and interleukin-17 (IL-17) aggravates the ischaemic injury of the brain tissue. However, it is poorly understood whether the NLPR3 inflammasome was involved in regulating and activating the IL-23/IL-17 axis in ischaemic stroke. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.031DOI Listing

RTN1-C is involved in high glucose-aggravated neuronal cell subjected to oxygen-glucose deprivation and reoxygenation injury via endoplasmic reticulum stress.

Brain Res Bull 2019 Apr 16. Epub 2019 Apr 16.

Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China. Electronic address:

Background: Patients suffering from diabetes mellitus experience poor outcomes after ischemic stroke. RTN1-C, ER-associated proteins localized in endoplasmic reticulum (ER) membrane, plays an important role in ER stress-induced apoptosis and regulates cellular susceptibility to different apoptosis pathways. Overexpression of RTN1-C can aggravate cerebral ischemia/reperfusion injury (IRI). Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.010DOI Listing
April 2019
1 Read

Protective cardiac conditioning by an atypical cytokine.

Clin Sci (Lond) 2019 Apr 18;133(8):933-937. Epub 2019 Apr 18.

Chair of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München (KUM), Ludwig-Maximilians-University (LMU), Munich 81377, Germany

Ischemic heart disease (IHD) represents the leading cause of morbidity and mortality worldwide. Therapy options generally aim at restoring the blood flow to the heart muscle and relieve the ischemic insult. Paradoxically, coronary artery reperfusion itself, both during emergency intervention in ST segment elevation myocardial infarction (STEMI) patients or in the setting of elective cardiac surgery, damages the heart muscle, a phenomenon known as myocardial ischemia-reperfusion (I/R) injury (IRI). Read More

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http://www.clinsci.org/lookup/doi/10.1042/CS20190036
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http://dx.doi.org/10.1042/CS20190036DOI Listing
April 2019
1 Read

Correction to: Non-Invasive Multimodality Imaging Directly Shows TRPM4 Inhibition Ameliorates Stroke Reperfusion Injury.

Transl Stroke Res 2019 Apr 17. Epub 2019 Apr 17.

Department of Research, National Neuroscience Institute, Singapore, Singapore.

The original version of the article unfortunately contained an error. Read More

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http://dx.doi.org/10.1007/s12975-019-00705-yDOI Listing

Chrysin prevents cognitive and hippocampal long-term potentiation deficits and inflammation in rat with cerebral hypoperfusion and reperfusion injury.

Life Sci 2019 Apr 13. Epub 2019 Apr 13.

Department of Physiology, Faculty of Medicine, Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Introduction: Ischemic stroke is one of the leading causes of death worldwide, and extensive efforts have focused on the neuroprotective strategies to minimize complications due to ischemia. This study aimed to examine neuroprotective potential of chrysin, as a natural potent antioxidative and anti-inflammatory agent in an animal model of bilateral common carotid artery occlusion and reperfusion (BCCAO/R).

Methods: Adult male Wistar rats (250-300 g) were randomly divided into 6 groups and submitted to either sham surgery or BCCAO/R after pretreatment with chrysin (10, 30 and 100 mg/kg, once daily, for 21 consecutive days) or saline containing %5 DMSO. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.027DOI Listing

microRNA-340-5p inhibits hypoxia/reoxygenation-induced apoptosis and oxidative stress in cardiomyocytes by regulating the Act1/NF-κB pathway.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Department of Cardiology, Gansu Provincial Hospital of TCM, Lanzhou, Gansu, China.

MicroRNAs (miRNAs) have been reported to play critical roles in the occurrence, progression, and treatment of many cardiovascular diseases. However, the molecular mechanism by which miRNA regulates target gene expression in ischemia-reperfusion (I/R) injury in acute myocardial infarction (AMI) is not entirely clear. MiR-340-5p was reported to be downregulated in acute ischemic stroke. Read More

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http://dx.doi.org/10.1002/jcb.28723DOI Listing
April 2019
1 Read

TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis.

Cell Death Dis 2019 Apr 15;10(5):328. Epub 2019 Apr 15.

Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Soochow University, Jiangsu Province, Suzhou, China.

Necroptosis contributes to ischemia-induced brain injury. Tumor necrosis factor (TNF) receptor associated factor 2 (TRAF2) has been reported to suppress necroptotic cell death under several pathological conditions. In this study, we investigated the role of TRAF2 in experimental stroke using a mouse middle cerebral artery occlusion (MCAO) model and in vitro cellular models. Read More

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http://dx.doi.org/10.1038/s41419-019-1558-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465397PMC
April 2019
1 Read

Cerebellar fastigial nucleus electrical stimulatin protects against cerebral ischemic damage by upregulating telomerase activity.

Restor Neurol Neurosci 2019 ;37(2):131-141

Department of Neurology, The First Affiliated Hospital of Guangxi Medical University in Nanning, China.

Background: Cerebellar fastigial nucleus electrical stimulation (FNS) in rats has been shown to protect against brain ischemia/reperfusion (I/R) damage. Activation of telomerase has been reported to provide neuroprotection in animal models of stroke.

Objective: The aim of this study was to explore whether precondition FNS increases the expression of telomerase reverse transcriptase (TERT) and telomerase activity in rats after cerebral I/R injury. Read More

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http://dx.doi.org/10.3233/RNN-180876DOI Listing
January 2019
2 Reads
2.490 Impact Factor

IMM-H004 Protects against Cerebral Ischemia Injury and Cardiopulmonary Complications via CKLF1 Mediated Inflammation Pathway in Adult and Aged Rats.

Int J Mol Sci 2019 Apr 3;20(7). Epub 2019 Apr 3.

Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces & College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.

(1) Background: Chemokine-like factor 1 (CKLF1) is a chemokine with potential to be a target for stroke therapy. Compound IMM-H004 is a novel coumarin derivative screened from a CKLF1/C-C chemokine receptor type 4 (CCR4) system and has been reported to improve cerebral ischemia/reperfusion injury. This study aims to investigate the protective effects of IMM-H004 on cerebral ischemia injury and its infectious cardiopulmonary complications in adult and aged rats from the CKLF1 perspective. Read More

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http://dx.doi.org/10.3390/ijms20071661DOI Listing
April 2019
2 Reads

Therapeutic potential of a TrkB agonistic antibody for ischemic brain injury.

Neurobiol Dis 2019 Apr 11. Epub 2019 Apr 11.

School of Pharmaceutical Sciences, IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing 100084, China; R&D Center for the Diagnosis and Treatment of Major Brain Diseases, Research Institute of Tsinghua University in Shenzhen, Shenzhen, Guangdong 518057, China. Electronic address:

The clinical trials employing neuroprotectants targeting single, early pathogenic mechanisms in stroke have so far been barely successful. We found in human postmortem stroke brains that in addition to apoptosis, necroptosis also contributed to neuronal damage. Thus, a new strategy targeting both mechanisms might be necessary. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09699961193009
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http://dx.doi.org/10.1016/j.nbd.2019.04.009DOI Listing
April 2019
11 Reads

TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury.

Free Radic Biol Med 2019 Apr 9. Epub 2019 Apr 9.

Department of Pharmacology, Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Science, Soochow University, Suzhou, 215123, China. Electronic address:

Autophagy has been reported to play protective and pathogenetic roles in cerebral ischemia/reperfusion (I/R)-induced neuronal injury. Our previous studies have shown that TP53-induced glycolysis and apoptosis regulator (TIGAR) ameliorates I/R-induced brain injury and reduces anti-cancer drug-induced autophagy activation. However, if TIGAR plays a regulatory role on autophagy in cerebral I/R injury is still unclear. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.002DOI Listing

Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents.

Acta Pharm Sin B 2019 Mar 7;9(2):335-350. Epub 2019 Jan 7.

Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.

Scavenging reactive oxygen species (ROS) by antioxidants is the important therapy to cerebral ischemia-reperfusion injury (CIRI) in stroke. The antioxidant with novel dual-antioxidant mechanism of directly scavenging ROS and indirectly through antioxidant pathway activation may be a promising CIRI therapeutic strategy. In our study, a series of chalcone analogues were designed and synthesized, and multiple potential chalcone analogues with dual antioxidant mechanisms were screened. Read More

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http://dx.doi.org/10.1016/j.apsb.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437665PMC
March 2019
2 Reads

Myosin1f-mediated neutrophil migration contributes to acute neuroinflammation and brain injury after stroke in mice.

J Neuroinflammation 2019 Apr 10;16(1):77. Epub 2019 Apr 10.

Department of Neurosurgery, Stanford University School of Medicine, 1201 Welch Road, MSLS Building, Room P306, Stanford, CA, 94305, USA.

Background: During the acute stroke phase, neutrophils from the peripheral blood are first to arrive in the ischemic brain, which then attracts other immune cells that exacerbate neuroinflammation in the ischemic tissue. Myosin1f was reported to specifically mediate neutrophil migration in the peripheral tissues, but whether it plays a critical role in the neuroinflammatory response after ischemic stroke remains unknown. In this study, we aim to test the hypothesis that myosin1f-mediated neutrophil migration is critical in acute neuroinflammation induced by ischemic stroke. Read More

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http://dx.doi.org/10.1186/s12974-019-1465-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456973PMC
April 2019
3 Reads

Specific contribution of mannose-binding lectin murine isoforms to brain ischemia/reperfusion injury.

Cell Mol Immunol 2019 Apr 9. Epub 2019 Apr 9.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Department of Neuroscience, Milan, Italy.

Mannose-binding lectin (MBL), an initiator of the lectin pathway (LP) of complement activation, is detrimental in ischemic stroke, as shown in clinical studies and rodent models. Whereas humans have one functional MBL protein, rodents have two isoforms, MBL-A and MBL-C, whose functions relative to that of human MBL are unknown. To permit the clinical translation of preclinical data, we aimed to define the specific contributions of MBL-A and MBL-C to brain ischemia. Read More

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http://dx.doi.org/10.1038/s41423-019-0225-1DOI Listing
April 2019
1 Read

Neurotherapeutic potential of erythropoietin after ischemic injury of the central nervous system.

Neural Regen Res 2019 Aug;14(8):1309-1312

Department of Vascular and Endovascular Surgery, Heinrich-Heine-University of Düsseldorf, Düsseldorf, Germany.

Erythropoietin (EPO) is one of the most successful biopharmaceuticals in history and is used for treating anemia of different origins. However, it became clear that EPO could also work in a neuroprotective, antiapoptotic, antioxidative, angiogenetic and neurotropic way. It causes stimulation of cells to delay cell apoptosis, especially in the central nervous system. Read More

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http://dx.doi.org/10.4103/1673-5374.253507DOI Listing
August 2019
1 Read

Microthrombus-Targeting Micelles for Neurovascular Remodeling and Enhanced Microcirculatory Perfusion in Acute Ischemic Stroke.

Adv Mater 2019 Apr 8:e1808361. Epub 2019 Apr 8.

Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 201203, China.

Reperfusion injury exists as the major obstacle to full recovery of neuron functions after ischemic stroke onset and clinical thrombolytic therapies. Complex cellular cascades including oxidative stress, neuroinflammation, and brain vascular impairment occur within neurovascular units, leading to microthrombus formation and ultimate neuron death. In this work, a multitarget micelle system is developed to simultaneously modulate various cell types involved in these events. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.2018083
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http://dx.doi.org/10.1002/adma.201808361DOI Listing
April 2019
4 Reads

Evaluation of the neuroprotective and antioxidant effects of Dorema aucheri extract on cerebral ischaemia-reperfusion injury in rats.

Pharm Biol 2019 Dec;57(1):255-262

b Department of Physiology and Biophysics School of Medicine , Baqiyatallah University of Medical Sciences , Tehran , Iran.

Context: The hydroalcoholic extract of Dorema aucheri Bilhar (Umbelliferae) (DA) leaves, a medicinal plant, has powerful antioxidant properties.

Objective: This study evaluates the neuroprotective effects of pre-treatment with DA leaves extract against cerebral ischaemia-induced brain injury through alteration of the antioxidant capacity.

Materials And Methods: The study was conducted in three groups of Wistar rats (N = 47) as follows; sham, control ischaemic and pre-treated ischaemic groups. Read More

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https://www.tandfonline.com/doi/full/10.1080/13880209.2019.1
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http://dx.doi.org/10.1080/13880209.2019.1597132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461074PMC
December 2019
5 Reads

Novel MASP-2 inhibitors developed directed evolution of human TFPI1 are potent lectin pathway inhibitors.

J Biol Chem 2019 Apr 5. Epub 2019 Apr 5.

Department of Biochemistry, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/C, Hungary.

The lectin pathway (LP) of the complement system is an important anti-microbial defense mechanism, but it also contributes significantly to ischemia reperfusion injury (IRI) associated with myocardial infarct, stroke and several other clinical conditions. Mannan-binding lectin (MBL)-associated serine proteinase 2 (MASP-2) is essential for LP activation and therefore it is a potential drug target. We have previously developed the first two generations of MASP-2 inhibitors by in vitro evolution of two unrelated canonical serine proteinase inhibitors. Read More

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http://dx.doi.org/10.1074/jbc.RA119.008315DOI Listing
April 2019
1 Read

KCNQ1OT1 promotes autophagy by regulating miR-200a/FOXO3/ATG7 pathway in cerebral ischemic stroke.

Aging Cell 2019 Apr 3:e12940. Epub 2019 Apr 3.

Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, China.

Dysregulation of long noncoding RNAs (lncRNAs) is associated with abnormal development and pathophysiology in the brain. Increasing evidence has indicated that ischemic stroke is becoming the most common cerebral disease in aging populations. The treatment of ischemic stroke is challenging, due in part to ischemia and reperfusion (I/R) injury. Read More

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http://dx.doi.org/10.1111/acel.12940DOI Listing
April 2019
5 Reads

Fluoxetine suppresses inflammatory reaction in microglia under OGD/R challenge via modulation of NF-κB signalling.

Biosci Rep 2019 Apr 3. Epub 2019 Apr 3.

Department of Anesthesiology, Changzheng Hospital,Second Military University, No.415, Fengyang Road, Shanghai, China

We aimed to investigate the anti-inflammatory role of fluoxetine, a selective serotonin reuptake inhibitor, in microglia (MG) and the mechanisms under oxygen glucose deprivation/reoxygenation (OGD/R). An OGD/R model on BV-2 cells was used for the study of microglia under ischemia/reperfusion injury in ischemic stroke. Lentiviral transfection was applied to knock down IκB-α. Read More

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http://dx.doi.org/10.1042/BSR20181584DOI Listing
April 2019
2 Reads

The Combined Extract of Black Sticky Rice and Dill Improves Poststroke Cognitive Impairment in Metabolic Syndrome Condition.

Oxid Med Cell Longev 2019 26;2019:9089035. Epub 2019 Feb 26.

Integrative Complementary Alternative Medicine Research and Development Center, Khon Kaen University, Khon Kaen 40002, Thailand.

Despite the increase in cognitive deficit following stroke in metabolic syndrome (MetS) condition, the therapeutic strategy is still limited. Since oxidative stress and neuroinflammation play the crucial roles on the pathophysiology of aforementioned conditions, the cognitive enhancing effect of the combined extract of and was considered based on their antioxidant, anti-inflammation, and neuroprotective effects together with the synergistic effect concept. Male Wistar rats weighing 180-220 g were induced metabolic syndrome-like condition by using a high-carbohydrate high-fat diet (HCHF diet). Read More

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https://www.hindawi.com/journals/omcl/2019/9089035/
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http://dx.doi.org/10.1155/2019/9089035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413387PMC
April 2019
14 Reads

Potential therapeutic roles of stem cells in ischemia-reperfusion injury.

Stem Cell Res 2019 Mar 16;37:101421. Epub 2019 Mar 16.

Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, USA. Electronic address:

Ischemia-reperfusion injury (I/RI), produced by an initial interruption of organ blood flow and its subsequent restoration, contributes significantly to the pathophysiologies of stroke, myocardial infarction, renal I/RI, intestinal I/RI and liver I/RI, which are major causes of disability (including transplant failure) and even mortality. While the restoration of blood flow is required to restore oxygen and nutrient requirements, reperfusion often triggers local and systemic inflammatory responses and subsequently elevate the ischemic insult where the duration of ischemia determines the magnitude of I/RI damage. I/RI increases vascular leakage, changes transcriptional and cell death programs, drives leukocyte entrapment and inflammation and oxidative stress in tissues. Read More

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http://dx.doi.org/10.1016/j.scr.2019.101421DOI Listing
March 2019
2 Reads

Anti-inflammatory Effects of Traditional Chinese Medicines on Preclinical Models of Brain Ischemia-Reperfusion-Injury: Prospects for Neuroprotective Drug Discovery and Therapy.

Front Pharmacol 2019 7;10:204. Epub 2019 Mar 7.

Center of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Macau, China.

Acquired brain ischemia-and reperfusion-injury (IRI), including both Ischemic stroke (IS) and Traumatic Brain injury (TBI), is one of the most common causes of disability and death in adults and represents a major burden in both western and developing countries worldwide. China's clinical neurological therapeutic experience in the use of traditional Chinese medicines (TCMs), including TCM-derived active compounds, Chinese herbs, TCM formulations and decoction, in brain IRI diseases indicated a trend of significant improvement in patients' neurological deficits, calling for blind, placebo-controlled and randomized clinical trials with careful meta-analysis evaluation. There are many TCMs in use for brain IRI therapy in China with significant therapeutic effects in preclinical studies using different brain IRI-animal. Read More

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http://dx.doi.org/10.3389/fphar.2019.00204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423897PMC
March 2019
1 Read

Homer1a Attenuates Endoplasmic Reticulum Stress-Induced Mitochondrial Stress After Ischemic Reperfusion Injury by Inhibiting the PERK Pathway.

Front Cell Neurosci 2019 15;13:101. Epub 2019 Mar 15.

Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Homer1a is the short form of a scaffold protein that plays a protective role in many forms of stress. However, the role of Homer1a in cerebral ischemia/reperfusion (I/R) injury and its potential mechanism is still unknown. In this study, we found that Homer1a was upregulated by oxygen and glucose deprivation (OGD) and that overexpression of Homer1a alleviated OGD-induced lactate dehydrogenase (LDH) release and cell death in cultured cortical neurons. Read More

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https://www.frontiersin.org/article/10.3389/fncel.2019.00101
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http://dx.doi.org/10.3389/fncel.2019.00101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428733PMC
March 2019
6 Reads
4.289 Impact Factor

Autoimmunity in acute ischemic stroke and the role of blood-brain barrier: the dark side or the light one?

Front Med 2019 Mar 30. Epub 2019 Mar 30.

Department of Pathology, Laboratory of the Mosaic of Autoimmunity, Saint Petersburg State University, Saint Petersburg, 199034, Russian Federation.

This article presents a synopsis of the current data on the mechanisms of blood-brain barrier (BBB) alteration and autoimmune response in acute ischemic stroke. Most researchers confirm the relationship between the severity of immunobiochemical changes and clinical outcome of acute ischemic stroke. Ischemic stroke is accompanied by aseptic inflammation, which alters the brain tissue and exposes the co-stimulatory molecules of the immune system and the neuronal antigens. Read More

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http://dx.doi.org/10.1007/s11684-019-0688-6DOI Listing
March 2019
1 Read

Inhibition of Calcium/Calmodulin-Dependent Protein Kinase IIα Suppresses Oxidative Stress in Cerebral Ischemic Rats Through Targeting Glucose 6-Phosphate Dehydrogenase.

Neurochem Res 2019 Mar 27. Epub 2019 Mar 27.

Neurological Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, No. 1 Eastern Jianshe Road, Zhengzhou, 450000, Henan, China.

Ischemic stroke is a leading cause of mortality and morbidity worldwide, and oxidative stress plays a significant role in the ischemia stage and reperfusion stage. Previous studies have indicated that both calcium/calmodulin-dependent protein kinase II (CaMKII) and glucose 6-phosphate dehydrogenase (G6PD) are involved in the oxidative stress. Thus, the aim of this study was to investigate the roles of CaMKIIα, an important isoform of CaMKII, and G6PD in a rat model of middle cerebral artery occlusion (MCAO). Read More

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http://dx.doi.org/10.1007/s11064-019-02785-6DOI Listing
March 2019
1 Read

Neuroimaging evolution of ischemia in men and women: an observational study.

Ann Clin Transl Neurol 2019 Mar 21;6(3):575-585. Epub 2019 Feb 21.

Department of Neurology Dell Medical School at The University of Texas Austin Texas.

Objective: We present an exploratory study for identification of sex differences in imaging biomarkers that could further refine selection of patients for acute reperfusion therapy and trials based on sex and imaging targets.

Methods: The Lesion Evolution in Stroke and Ischemia On Neuroimaging (LESION) study included consecutive acute stroke patients who underwent MRI within 24 h of time from last known well and prior to therapy. Those demonstrating a potential therapeutic target on imaging were identified by presence of: (1) arterial occlusion on angiography, (2) focal ischemic region on perfusion maps, or (3) a mismatch of perfusion versus diffusion imaging lesion size. Read More

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http://doi.wiley.com/10.1002/acn3.733
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http://dx.doi.org/10.1002/acn3.733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414486PMC
March 2019
6 Reads

HMG-CoA Reductase Inhibitors Attenuate Neuronal Damage by Suppressing Oxygen Glucose Deprivation-Induced Activated Microglial Cells.

Neural Plast 2019 17;2019:7675496. Epub 2019 Feb 17.

The First Affiliated Hospital, Jinan University, Guangzhou, China.

Ischemic stroke is usually followed by inflammatory responses mediated by microglia. However, the effect of statins on directly preventing posthypoxia microglia inflammatory factors to prevent injury to surrounding healthy neurons is unclear. Atorvastatin and rosuvastatin, which have different physical properties regarding their lipid and water solubility, are the most common HMG-CoA reductase inhibitors (statins) and might directly block posthypoxia microglia inflammatory factors to prevent injury to surrounding neurons. Read More

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https://www.hindawi.com/journals/np/2019/7675496/
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http://dx.doi.org/10.1155/2019/7675496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397982PMC
February 2019
3 Reads

Fn-EDA (Fibronectin Containing Extra Domain A) in the Plasma, but Not Endothelial Cells, Exacerbates Stroke Outcome by Promoting Thrombo-Inflammation.

Stroke 2019 May;50(5):1201-1209

From the Division of Hematology/Oncology, Department of Internal Medicine (N.D., M.R.C., M.J., A.B., M.N., P.D., A.K.C.), University of Iowa, Iowa City.

Background and Purpose- Cellular Fn-EDA (fibronectin containing extra domain A) is expressed in activated endothelial cells and elevated in circulation in patients with cardiovascular diseases. Although global deficiency of Fn-EDA in mice improves stroke outcome, the specific contribution of plasma versus endothelium Fn-EDA in stroke outcome is currently unknown. We investigated the role of plasma versus endothelial Fn-EDA in stroke exacerbation in the comorbid condition of hyperlipidemia. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476677PMC
May 2019
5.723 Impact Factor

Inhibition of HDAC3 Ameliorates Cerebral Ischemia Reperfusion Injury in Diabetic Mice In Vivo and In Vitro.

J Diabetes Res 2019 13;2019:8520856. Epub 2019 Feb 13.

Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province 430060, China.

Background: A substantial increase in histone deacetylase 3 (HDAC3) expression is implicated in the pathological process of diabetes and stroke. However, it is unclear whether HDAC3 plays an important role in diabetes complicated with stroke. We aimed to explore the role and the potential mechanisms of HDAC3 in cerebral ischemia/reperfusion (I/R) injury in diabetic state. Read More

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http://dx.doi.org/10.1155/2019/8520856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393870PMC
February 2019
1 Read

Ischemia-Reperfusion Injury in Sickle Cell Disease: From Basics to Therapeutics.

Am J Pathol 2019 Apr;189(4):706-718

Department of Molecular & Cellular Physiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana. Electronic address:

Sickle cell disease (SCD) is one of the most common hereditary hemoglobinopathies worldwide, affecting almost 400,000 newborns globally each year. It is characterized by chronic hemolytic anemia and endothelial dysfunction, resulting in a constant state of disruption of the vascular system and leading to recurrent episodes of ischemia-reperfusion injury (I/RI) to multiple organ systems. I/RI is a fundamental vascular pathobiological paradigm and contributes to morbidity and mortality in a wide range of conditions, including myocardial infarction, stroke, acute kidney injury, and transplantation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029440183062
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http://dx.doi.org/10.1016/j.ajpath.2018.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446225PMC
April 2019
6 Reads

miRNA-145-5p induces apoptosis after ischemia-reperfusion by targeting dual specificity phosphatase 6.

J Cell Physiol 2019 Mar 18. Epub 2019 Mar 18.

Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.

Disorders mainly caused by ischemia-reperfusion (I/R), including stroke and myocardial infarction, is linked to debilitating health conditions and death. Recent research indicates that microRNAs (miRNAs) mediate the process of ischemic pathology. This study investigated the effects of miR-145-5p in regulating myocardial ischemic injury. Read More

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http://dx.doi.org/10.1002/jcp.28291DOI Listing

Two-vessel Occlusion Mouse Model of Cerebral Ischemia-reperfusion.

J Vis Exp 2019 Mar 1(145). Epub 2019 Mar 1.

Department of Medical Research, Taipei Medical University Hospital, Taipei Medical University;

In this study, a middle cerebral artery (MCA) occlusion mouse model is employed to study cerebral ischemia-reperfusion. A reproducible and reliable mouse model is useful for investigating the pathophysiology of cerebral ischemia-reperfusion and determining potential therapeutic strategies for patients with stroke. Variations in the anatomy of the circle of Willis of C57BL/6 mice affects their infarct volume after cerebral-ischemia-induced injury. Read More

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http://dx.doi.org/10.3791/59078DOI Listing
March 2019
1 Read

Initial Experience in Direct Aspiration Thrombectomy Utilizing a Novel 0.071-inch Aspiration Catheter.

World Neurosurg 2019 Mar 14. Epub 2019 Mar 14.

Department of Neurosurgery, Medical University of South Carolina, Charleston, SC, USA.

Introduction: ADAPT (A Direct Aspiration First Pass Technique) is one of the most widely used techniques in mechanical thrombectomy. Aspiration catheter size plays a major role in the success of this technique. The AXS Vecta (Stryker Neurovascular, Fremont, CA) aspiration catheter is the first approved 0. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.055DOI Listing
March 2019
2 Reads

Neuroprotection and Vasculoprotection using Genetically Targeted Protease-Ligands.

Brain Res 2019 Mar 14. Epub 2019 Mar 14.

Department of Neurology, Cedars Sinai Medical Center, 127 S San Vicente Blvd, Los Angeles, CA, 90048, United States. Electronic address:

Thrombin and activated protein C (APC) are known coagulation factors that exhibit profound effects in brain by acting on the protease activated receptor (PAR). The wild type (WT) proteases appear to impact cell survival powerfully, and therapeutic forms of APC are under development. Engineered recombinant thrombin or APC were designed to separate their procoagulant or anticoagulant effects from their cytoprotective properties. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.010DOI Listing

Neuro-protective effect of monomethyl fumarate on ischemia reperfusion injury in rats: Role of Nrf2/HO1 pathway in peri-infarct region.

Neurochem Int 2019 Jun 14;126:96-108. Epub 2019 Mar 14.

Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.

Post stroke recanalization has been associated with increased risk of oxidative stress. Stimulating endogenous antioxidant pathway by activation of nuclear factor erythroid-2-related factor-2 (Nrf2) plays a key role in neuronal defense against inflammation and oxidative stress in penumbra. Here, we explored whether monomethyl fumarate (MMF) could produce neuro-protection after ischemia/reperfusion (I/R) injury via Nrf2/HO1 activation. Read More

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http://dx.doi.org/10.1016/j.neuint.2019.03.010DOI Listing
June 2019
2 Reads

An update on the association of protein kinases with cardiovascular diseases.

Curr Pharm Des 2019 03 11. Epub 2019 Mar 11.

Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh (U.P.). India.

Background: Protein kinases are the enzymes involved in phosphorylation of different proteins and leads to functional changes in those proteins. They are classified into the AGC (Protein kinase A/ Protein kinase G/ Protein kinase C) families of protein and Rho-associated kinase protein (ROCK) and belong to serine-threonine kinases family. The AGC family of kinases are involved in G-protein stimuli, muscle contraction, platelet biology and lipid signaling. Read More

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http://dx.doi.org/10.2174/1381612825666190312115140DOI Listing
March 2019
2 Reads

Mitochondrial complex I deficiency and cardiovascular diseases: current evidence and future directions.

J Mol Med (Berl) 2019 Mar 12. Epub 2019 Mar 12.

Department of Angiocardioneurology, IRCCS Neuromed, Località Camerelle, 86077, Pozzilli, IS, Italy.

Compelling evidence demonstrates the emerging role of mitochondrial complex I deficiency in the onset and development of cardiovascular diseases (CVDs). In particular, defects in single subunits of mitochondrial complex I have been associated with cardiac hypertrophy, ischemia/reperfusion injury, as well as diabetic complications and stroke in pre-clinical studies. Moreover, data obtained in humans revealed that genes coding for complex I proteins were associated with different CVDs. Read More

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http://dx.doi.org/10.1007/s00109-019-01771-3DOI Listing

Sex Differences in Ischemia/Reperfusion Injury: The Role of Mitochondrial Permeability Transition.

Neurochem Res 2019 Mar 12. Epub 2019 Mar 12.

Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st St., RR506, New York, NY, 10065, USA.

Brain and heart ischemia are among the leading causes of death and disability in both men and women, but there are significant sex differences in the incidence and severity of these diseases. Ca dysregulation in response to ischemia/reperfusion injury (I/RI) is a well-recognized pathogenic mechanism leading to the death of affected cells. Excess intracellular Ca causes mitochondrial matrix Ca overload that can result in mitochondrial permeability transition (MPT), which can have severe consequences for mitochondrial function and trigger cell death. Read More

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http://link.springer.com/10.1007/s11064-019-02769-6
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http://dx.doi.org/10.1007/s11064-019-02769-6DOI Listing
March 2019
9 Reads

A Novel Na-K-Cl Cotransporter 1 Inhibitor STS66* Reduces Brain Damage in Mice After Ischemic Stroke.

Stroke 2019 Apr;50(4):1021-1025

From the Department of Neurology (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.

Background and Purpose- Inhibition of brain NKCC1 (Na-K-Cl cotransporter 1) with bumetanide (BMT) is of interest in ischemic stroke therapy. However, its poor brain penetration limits the application. In this study, we investigated the efficacy of 2 novel NKCC1 inhibitors, a lipophilic BMT prodrug STS5 (2-(Dimethylamino)ethyl 3-(butylamino)-4-phenoxy-5-sulfamoyl-benzoate;hydrochloride) and a novel NKCC1 inhibitor STS66 (3-(Butylamino)-2-phenoxy-5-[(2,2,2-trifluoroethylamino)methyl]benzenesulfonamide), on reducing ischemic brain injury. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.024287DOI Listing
April 2019
2 Reads

Dose-Dependent Influences of Ethanol on Ischemic Stroke: Role of Inflammation.

Front Cell Neurosci 2019 12;13. Epub 2019 Feb 12.

Department of Cellular Biology & Anatomy, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, United States.

Chronic ethanol consumption dose-dependently affects both incidence and prognosis of ischemic stroke. Our goal was to determine whether the influence of chronic ethanol consumption on ischemic stroke is related to an altered inflammatory profile in the brain. Male C57BL/6J mice were divided into six groups and gavage fed with 0. Read More

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https://www.frontiersin.org/article/10.3389/fncel.2019.00006
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http://dx.doi.org/10.3389/fncel.2019.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396710PMC
February 2019
5 Reads
4.289 Impact Factor

Management of Blood Pressure During and After Recanalization Therapy for Acute Ischemic Stroke.

Front Neurol 2019 21;10:138. Epub 2019 Feb 21.

Department of Neurology, University of California, San Francisco, San Francisco, CA, United States.

Ischemic stroke is a common neurologic condition and can lead to significant long term disability and death. Observational studies have demonstrated worse outcomes in patients presenting with the extremes of blood pressure as well as with hemodynamic variability. Despite these associations, optimal hemodynamic management in the immediate period of ischemic stroke remains an unresolved issue, particularly in the modern era of revascularization therapies. Read More

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http://dx.doi.org/10.3389/fneur.2019.00138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394277PMC
February 2019
2 Reads

Exosomes from LPS-stimulated macrophages induce neuroprotection and functional improvement after ischemic stroke by modulating microglial polarization.

Biomater Sci 2019 Apr;7(5):2037-2049

School of Pharmacy, Jinzhou Medical University, Jinzhou 121000, P R China.

Inflammation occurs throughout the progression of cerebral ischemia/reperfusion and mediates myriads of pathological events following an ischemic insult. After ischemic stroke, inflammation was significantly triggered and microglia were activated to phenotypes (M1) typically releasing pro-inflammatory mediators, thus inducing neuron apoptosis and exacerbating brain injury. Therefore, shifting the polarization of microglia from the detrimental pro-inflammatory M1 phenotype to the beneficial anti-inflammatory M2 phenotype seems a promising therapeutic strategy in ischemic stroke. Read More

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http://dx.doi.org/10.1039/c8bm01449cDOI Listing
April 2019
1 Read

Neurotherapeutic potential of kolaviron on neurotransmitter dysregulation, excitotoxicity, mitochondrial electron transport chain dysfunction and redox imbalance in 2-VO brain ischemia/reperfusion injury.

Biomed Pharmacother 2019 Mar 8;111:859-872. Epub 2019 Jan 8.

Phytomedicine, Biochemical Pharmacology and Toxicology Laboratories, Department of Biochemistry, School of Sciences, The Federal University of Technology, PMB 704, Akure, Nigeria. Electronic address:

This study investigated the effects of post-treatment with kolaviron on a 2-Vessel Occlusion (2-VO) model of cerebral ischemia/reperfusion (I/R) injury in rats to ascertain its level of efficacy as a potential therapeutic agent for stroke. Male Wistar rats submitted to 30 min of bilateral common carotid artery occlusion and 24 h of reperfusion were treated with kolaviron (25-100 mg/kg) or 20 mg/kg quercetin immediately after reperfusion and 2 h post reperfusion. At the end of the period of reperfusion, animals were scored for motor and cognitive deficits. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.12.144DOI Listing
March 2019
4 Reads

Neuroprotective Effects of BHDPC, a Novel Neuroprotectant, on Experimental Stroke by Modulating Microglia Polarization.

ACS Chem Neurosci 2019 Mar 19. Epub 2019 Mar 19.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences , University of Macau , Macau 999078 , China.

This study mainly investigated the therapeutic effects of BHDPC on ischemic stroke and its underlying mechanisms. In vivo, the transient middle cerebral artery occlusion (MCAO) was used to induce ischemic model. In vitro, oxygen and glucose deprivation/reperfusion (OGD/R)-induced ischemic stroke in BV-2 microglia and primary neurons, and bEnd. Read More

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http://dx.doi.org/10.1021/acschemneuro.8b00713DOI Listing
March 2019
1 Read