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BMJ Case Rep 2019 Apr 15;12(4). Epub 2019 Apr 15.

Department of Internal Medicine, Okinawa Chubu Hospital, Uruma, Japan.

Nephrotic range proteinuria and metabolic alkalosis are unusual findings in large vessel vasculitis. In this case, renovascular hypertension with unilateral renal artery stenosis in Takayasu arteritis was complicated by nephrotic range proteinuria. Symptoms resolved after angioplasty, although non-nephrotic proteinuria persisted. Read More

Turk Kardiyol Dern Ars 2019 Apr;47(3):185-190

Department of Cardiology, Haseki Training and Research Hospital, İstanbul, Turkey.

Objective: Various hematological blood count parameters, including the neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV), were analyzed to assess differences in patients with renovascular (RVH) and essential hypertension (EH).

Methods: A propensity score analysis was performed to match 51 patients with RVH and 173 patients with EH. After matching, 49 pairs of patients were compared. Read More

Front Neurosci 2019 26;13:282. Epub 2019 Mar 26.

Shaanxi Key Laboratory of Chinese Medicine Encephalopathy, Shaanxi University of Chinese Medicine, Xianyang, China.

Electroacupuncture (EA) has been used to treat numerous diseases, including hypertension. This study aimed to investigate the long-term effect and underlying mechanisms of EA stimulation at the LI11 point on the hypertension and sympathetic nerve activity in two-kidney, one-clip (2K1C) hypertensive rats. EA (0. Read More

Biol Pharm Bull 2019 Apr 5. Epub 2019 Apr 5.

Department of Physiology, Fasa University of Medical Sciences.

Alamandine is a new member of the angiotensin family. Here, we studied the mRNA and protein expression of cardiac angiotensin-converting enzyme 2) ACE2 (in the chronic phase of a rat model of two-kidney, one-clip hypertension (2KIC) , and the effects of 2-week alamandine infusion on blood pressure, cardiac indices, and ACE2 mRNA and protein expression in the hearts. The rats were subjected to to sham-operation or placement of plexiglass clips around the left renal artery. Read More

Protein Pept Lett 2019 Apr 5. Epub 2019 Apr 5.

Department of Morphology - Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG. Brazil.

Background: Angiotensin converting enzyme (ACE) 2 is an important modulator of the renin angiotensin system (RAS) and the RAS plays a central role in renovascular hypertension. Very few studies investigated the role of components of the counterregulatory RAS axis (ACE2, Ang-(1-7) and Mas receptor) in renovascular hypertension and the results are controversial.

Objective: The aim of this study was to investigate the effects of diminazene aceturate (DIZE) administration on renal function and renal inflammation parameters in 2K1C hypertensive rats. Read More

J Vasc Res 2019 Apr 4;56(1):28-38. Epub 2019 Apr 4.

Department of Molecular Pathology, Faculty of Medicine, Graduate School of Medical Sciences, University of Yamanashi, Yamanashi, Japan,

Background: Hypertension is a major risk factor for atherosclerotic disease. However, it is still not clear whether mechanical stress caused by hypertension directly affects the atherosclerotic development in the aorta and coronary arteries.

Objectives And Methods: We generated a hypertensive (HTN) rabbit model by surgical removal of the left kidney and partial ligation of the right renal artery. Read More

Cardiovasc Revasc Med 2019 Mar;20(3):175-176

Kidney Int 2019 Apr;95(4):948-957

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:

The relationships between renal blood flow (RBF), tissue oxygenation, and inflammatory injury in atherosclerotic renovascular disease (ARVD) are poorly understood. We sought to correlate RBF and tissue hypoxia with glomerular filtration rate (GFR) in 48 kidneys from patients with ARVD stratified by single kidney iothalamate GFR (sGFR). Oxygenation was assessed by blood oxygenation level dependent magnetic resonance imaging (BOLD MRI), which provides an index for the levels of deoxyhemoglobin within a defined volume of tissue (R2*). Read More

JACC Cardiovasc Interv 2019 Mar;12(6):505-517

Department of Cardiology at Ochsner Clinic Foundation, New Orleans, Louisiana.

Atherosclerotic renal artery stenosis is the leading cause of secondary hypertension and may lead to resistant (refractory) hypertension, progressive decline in renal function, and cardiac destabilization syndromes (pulmonary edema, recurrent heart failure, or acute coronary syndromes) despite guideline-directed medical therapy. Although randomized controlled trials comparing medical therapy with medical therapy and renal artery stenting have failed to show a benefit for renal artery stenting, according to comparative effectiveness reviews by the Agency for Healthcare Research and Quality, the trials may not have enrolled patients with the most severe atherosclerotic renal artery stenosis, who would be more likely to benefit from renal stenting. Because of limitations of conventional angiography, it is critical that the hemodynamic severity of moderately severe (50% to 70%) atherosclerotic renal artery stenosis lesions be confirmed on hemodynamic measurement. Read More

J Hypertens 2019 Mar 14. Epub 2019 Mar 14.

Hirakata General Hospital for Developmental Disorders, Hirakata.

Objective: Hypertension is one of the most prevalent diseases in humans who live a modern lifestyle. Alongside more effective care, clarification of the genetic background of hypertension is urgently required. Gene expression in mesenteric resistance arteries of spontaneously hypertensive rats (SHR), stroke-prone SHR (SHRSP) and two types of renal hypertensive Wistar Kyoto rats (WKY), two kidneys and one clip renal hypertensive rat (2K1C) and one kidney and one clip renal hypertensive rat (1K1C), was compared using DNA microarrays. Read More

Am J Hypertens 2019 Mar 14. Epub 2019 Mar 14.

Monash Cardiovascular Research Centre, MonashHEART, Monash Health, Monash University, Melbourne, Australia.

Familial hypercholesterolemia (FH) is a common hereditary lipid disorder associated with substantial risk of premature atherosclerotic cardiovascular disease (ASCVD). We report an interesting newly diagnosed index case of FH in a 31 year old man who presented to the hospital with a ST-elevated myocardial infarction (STEMI). He had a background of inadequately treated hypertension and hypercholesterolemia. Read More

Int J Hypertens 2019 30;2019:3872065. Epub 2019 Jan 30.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.

Background: Percutaneous transluminal renal angioplasty (PTRA) improves blood pressure (BP) and renal function only in selected patients with atherosclerotic renovascular disease (ARVD). Hyperuricemia is associated with elevated risk for hypertension and chronic renal disease, but its role in renovascular hypertension is unclear. We hypothesized that hyperuricemia negatively impacts renal and BP outcomes among patients with ARVD undergoing PTRA. Read More

Acta Physiol (Oxf) 2019 Feb 25:e13267. Epub 2019 Feb 25.

Department of Internal Medicine, Divisions of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.

Aims: Patients with renovascular hypertension (RVH) exhibit elevated urinary mtDNA copy numbers, considered to constitute surrogate markers of renal mitochondrial injury. The modest success of percutaneous transluminal renal angioplasty (PTRA) in restoring renal function in RVH has been postulated to be partly attributable to acute reperfusion injury. We hypothesized that mitoprotection during revascularization would ameliorate PTRA-induced renal mitochondrial injury, reflected in elevated urinary mtDNA copy numbers and improve blood pressure and functional outcomes 3 months later. Read More

Intern Med 2019 Feb 25. Epub 2019 Feb 25.

Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Japan.

We experienced a young woman with congestive heart failure (CHF) caused by renovascular hypertension (RVH) and subsequent hypertensive heart disease. She underwent tumor resection and intraoperative radiation therapy because of neuroblastoma at age 2. She was diagnosed with RVH and hypertensive heart disease due to radiation-induced renal artery stenosis at age 12. Read More

Hypertens Res 2019 May 22;42(5):754-757. Epub 2019 Feb 22.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Clin Med Insights Case Rep 2019 7;12:1179547619828721. Epub 2019 Feb 7.

Department of Interventional Radiology, Queen's Medical Centre (QMC), Nottingham University Hospitals NHS Trust, Nottingham, UK.

Aims: Renovascular hypertension is a rare cause of paediatric hypertension. It is however, a potentially treatable cause particularly when caused by renal artery stenosis (RAS).

Materials And Methods: We present the case of an 11-month-old girl presenting with cardiac dysfunction. Read More

Exp Physiol 2019 Feb 21. Epub 2019 Feb 21.

Laboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

New Findings: What is the central question of this study? Can a single bone marrow mononuclear cell (BMMC) transplant into the subcapsular region of kidney improve cellular communication and adhesion, while restoring renal tissue cytoarchitecture and function during renovascular hypertension? What is the main finding and its importance? The BMMC transplantation restored connexin 40 expression and led to recovery of N- and E-cadherin levels within 15 days. It was observed, for the first time, that BMMC transplantation restores expression of nephrin, a component of the glomerular filtration barrier related to podocytes and the glomerular basal membrane.

Abstract: Stem cell therapy has emerged as a potential treatment for renal diseases owing to the regenerative potential of stem cells. Read More

Urol Ann 2019 Jan-Mar;11(1):46-52

Department of Urology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Introduction: With significant advances in the area of interventional radiology, angioplasty and stenting have become preferred first-line treatment in patients with significant renal artery stenosis. However, not all patients have favorable anatomy to undergo minimally invasive treatments, and reconstruction of the renal artery is an option. In select cases, either improved renal function or maintenance of existing function and sometimes resolution of hypertension can follow surgical treatment. Read More

Hypertens Res 2019 May 21;42(5):749-751. Epub 2019 Feb 21.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

J Ultrasound Med 2019 Feb 18. Epub 2019 Feb 18.

Department of Radiology, Seoul National University Hospital, Seoul, Korea.

Objectives: The diagnostic role of an ultrasound (US) and plasma renin activity (PRA) combination is unknown, despite the usefulness of Doppler US as a screening tool for renovascular hypertension (RVHT). The purpose of this study was to evaluate the diagnostic usefulness of US for RVHT in children stratified according to PRA.

Methods: We identified 336 children who underwent renal Doppler US examinations for hypertension and divided them into a high-renin group (n = 177) and a normal-renin group (n = 159) based on PRA and stratified them by age. Read More

Sci Rep 2019 Feb 18;9(1):2223. Epub 2019 Feb 18.

Department of Physiology, School of Medicine, University of Louisville, Louisville, KY, 40292, USA.

The accumulation of homocysteine (Hcy) during chronic kidney failure (CKD) can exert toxic effects on the glomeruli and tubulo-interstitial region. Among the potential mechanisms, the formation of highly reactive metabolite, Hcy thiolactone, is known to modify proteins by N-homocysteinylation, leading to protein degradation, stress and impaired function. Previous studies documented impaired nitric oxide production and altered caveolin expression in hyperhomocysteinemia (HHcy), leading to endothelial dysfunction. Read More

Iran J Vet Res 2018 ;19(4):304-309

Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, Madras Veterinary College, TANUVAS, Chennai-600007, India.

Present study was conducted with the objectives of determining the renal vascular resistance in dogs with diabetes mellitus and to study the correlation between the indices of renovascular resistance with glycemic status, systolic blood pressure (SBP) and proteinuria in dogs with diabetes mellitus. This study was conducted on seventeen diabetic dogs and ten apparently healthy dogs. Increased renal resistive index (RI) and pulsatility index (PI) were observed in diabetic dogs as compared to healthy dogs. Read More

Nitric Oxide 2019 May 14;86:12-20. Epub 2019 Feb 14.

Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil. Electronic address:

Purpose: This study investigated the intracellular mechanisms involved in the vasodilatation induced by the classic NO donor SNP and the non-classic NO donor cis-[Ru(bpy)2(py)(NO2)](PF6) (or RuBPY) in mesenteric resistance arteries obtained from renal hypertensive (2K-1C) and normotensive (2K) rats.

Methods: On the basis of fluorimetric assays in cultured vascular smooth muscle cells (VSMCs) isolated from 2K-1C and 2K rats, we measured NO release from SNP and RuBPY, cytosolic Ca concentration ([Ca]c), and reactive oxygen species (ROS) with the selective probes DAF-2DA, Fluo-3AM and the more selective probe for peroxynitrite (7-CBA), respectively. We determined isometric tension in mesenteric arteries to assess SNP- and RuBPY-induced relaxation. Read More

J Ultrason 2018 ;18(75):338-343

Department of General Surgery and Endocrinology, Medical University of Warsaw , Poland.

The present clinical practice recommendations are addressed to physicians of all specialties, who perform Doppler ultrasound examinations of the kidneys on a daily basis, and in particular to specialists in radiology and imaging diagnostics. The recommendations were based on the Ultrasonography Standards of the Polish Ultrasound Society and current scientific reports consistent with Evidence Based Medicine. The paper discusses patient preparation protocol, examinat ion technique with particular emphasis on patient's position allowing to obtain proper Doppler angle of insonation, as well as diagnostic limitations of the technique. Read More

Rev Assoc Med Bras (1992) 2018 Aug;64(8):723-728

. Pediatric Nephrology Unit, Institute of Children, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brasil.

Aim: To describe the incidence, diagnosis, and management of systemic arterial hypertension related to renal artery stenosis in patients with Williams-Beuren syndrome.

Methods: Sixty-five patients with Williams-Beuren syndrome were evaluated for hypertension. Enrolled patients underwent Doppler sonography of the renal arteries and Doppler echocardiography. Read More

Nephrology (Carlton) 2019 Jan 20. Epub 2019 Jan 20.

NHMRC CKD.CRE and CKD.QLD, University of Queensland, Brisbane, Queensland, Australia.

Background: Chronic Kidney Disease, Queensland (CKD.QLD) is a multidisciplinary, collaborative research platform for CKD in Queensland. All public renal services contribute towards the CKD Registry, including Toowoomba Hospital which is a referral hospital for Darling Downs Health (DDH) serving largely regional population in Queensland. Read More

Cardiovasc Res 2019 Jan 18. Epub 2019 Jan 18.

Department of Pharmacology, Carver College of Medicine, The University of Iowa, Iowa City, IA.

Cureus 2018 Nov 12;10(11):e3573. Epub 2018 Nov 12.

Neurology, University of Missouri, Columbia, USA.

Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiologic syndrome resulting in subcortical vasogenic edema appreciated on T2/fluid-attenuated inversion recovery (FLAIR) sequence of magnetic resonance imaging (MRI). PRES classically involves bilateral parieto-occipital lobes and is usually reversible. Atypical variant of PRES includes the involvement of brainstem, basal ganglia, thalami, or periventricular white matter. Read More

Vasc Med 2019 04 16;24(2):164-189. Epub 2019 Jan 16.

6 Paris Descartes University, Paris, France.

This article is a comprehensive document on the diagnosis and management of fibromuscular dysplasia (FMD), which was commissioned by the working group 'Hypertension and the Kidney' of the European Society of Hypertension (ESH) and the Society for Vascular Medicine (SVM). This document updates previous consensus documents/scientific statements on FMD published in 2014 with full harmonization of the position of European and US experts. In addition to practical consensus-based clinical recommendations, including a consensus protocol for catheter-based angiography and percutaneous angioplasty for renal FMD, the document also includes the first analysis of the European/International FMD Registry and provides updated data from the US Registry for FMD. Read More

BMC Nephrol 2019 Jan 14;20(1):19. Epub 2019 Jan 14.

Section of Nephrology, Department of Medicine, Regina General Hospital, 1440, 14th Avenue, Regina, S4P 0W5, Canada.

Background: We report a 61-year-old female with end-stage renal disease (ESRD) secondary to polycystic kidney disease (PKD) complicated by intradialytic hypertension (IDH). Increased sympathetic drive leading to increased stroke volume and/or vasoconstriction with an inappropriate increase in peripheral vascular resistance (PVR) has been postulated to be the cause of IDH.

Case Presentation: Attempts to control her blood pressure by reducing her goal weight; increasing dialysis times/ frequency and decreasing her sodium concentrate in the dialysis fluid were unsuccessful. Read More

F1000Res 2018 29;7. Epub 2018 Nov 29.

Departments of Physiology and Biophysics, Medicine, and Radiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA.

Atherosclerotic renovascular disease (ARVD) is an unresolved therapeutic dilemma despite extensive pre-clinical and clinical studies. The pathophysiology of the disease has been widely studied, and many factors that may be involved in progressive renal injury and cardiovascular risk associated with ARVD have been identified. However, therapies and clinical trials have focused largely on attempts to resolve renal artery stenosis without considering the potential need to treat the renal parenchyma beyond the obstruction. Read More

Chin Med J (Engl) 2019 Jan;132(1):63-68

Department of Sonography, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.

Background: Renal artery stenosis (RAS) is always associated with abnormalities in renal microvascular perfusion (RMP). However, few imaging methods can simultaneously evaluate the degree of luminal stenosis and RMP. Thus, this study will aim to evaluate the feasibility of using contrast-enhanced ultrasound (CEUS) for assessing both RAS and RMP to achieve a one-stop assessment of patients with suspected renovascular hypertension. Read More

Hypertens Res 2019 May 8;42(5):587-597. Epub 2019 Jan 8.

Department of Physiology and Pathology, School of Dentistry, São Paulo State University, UNESP, Araraquara, SP, Brazil.

The rodent renovascular hypertension model has been used to investigate the mechanisms promoting hypertension. The importance of the carotid body for renovascular hypertension has been demonstrated. As the commissural NTS (cNTS) is the first synaptic site in the central nervous system that receives information from carotid body chemoreceptors, we evaluated the contribution of cNTS to renovascular hypertension in the present study. Read More

Phytomedicine 2019 Jan 22;52:216-224. Epub 2018 Sep 22.

Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Xi'an Jiaotong University, Xi'an 710061, China. Electronic address:

Background: Berberine (BBR), a Chinese traditional herbal medicine, has many pharmacologic benefits such as anti-inflammation and anti-oxidation. It is widely used in clinical treatment of cardiovascular diseases such as hypertension. However, the mechanism of how BBR attenuates hypertension through affecting central neural system is not clear. Read More

Hypertens Res 2019 May 20;42(5):628-640. Epub 2018 Dec 20.

Department of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.

The underlying mechanisms by which renal denervation (RD) decreases blood pressure (BP) remain incompletely understood. In this study, we investigated the effects of ischemic kidney denervation on different sympathetic outflows, brain and renal expression of angiotensin-II receptors, oxidative stress and renal function markers in the 2-kidney, 1-clip (2K-1C) rat model. Surgical RD was performed in Wistar male rats 4-5 weeks after clip implantation. Read More

J Clin Rheumatol 2018 Dec 18. Epub 2018 Dec 18.

Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.

Int J Surg Case Rep 2019 24;54:79-82. Epub 2018 Nov 24.

Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine, Aomori, Japan. Electronic address:

Introduction: Middle aortic syndrome (MAS) combined with thoracic aortic aneurysm (TAA) is a rare vascular disease. One stage open surgery to treat this condition, becomes a challenge for our cardiovascular surgery.

Presentation Of Case: A 69-year-old man presented with a saccular type aortic arch aneurysm, shaggy aorta and severe atherosclerotic stenosis of the thoracoabdominal aorta with middle aortic syndrome and aberrant right subclavian artery, renovascular hypertension, renal dysfunction, and intermittent claudication of both legs. Read More

Case Rep Pediatr 2018 31;2018:5957987. Epub 2018 Oct 31.

1st Department of Pediatrics, Aristotle University Thessaloniki, Hippokration Hospital, Thessaloniki, Greece.

Arterial hypertension is a common finding in patients with neurofibromatosis (NF) type 1. Renovascular hypertension due to renal artery stenosis or midaortic syndrome could be the underlying cause. We report the case of a 4-year-old girl with NF type 1 and midaortic syndrome whose changes in blood pressure and pulse wave velocity suggested the evolution of vasculopathy, diagnosis of renovascular hypertension, and provided insights of response to treatment. Read More

Eurasian J Med 2018 Oct;50(3):210-212

Department of Cardiology, Istanbul Medeniyet University School of Medicine, İstanbul, Turkey.

A 23-year-old female patient with factor VII (FVII) deficiency was admitted with severe hypertension and renal failure. Brachial arterial pressures were 230/120 and 220/115 mm/Hg on the right and left arms, respectively. There was no blood pressure difference between the arms. Read More

Turk J Pediatr 2018 ;60(3):331-334

Departments of Vascular Surgery, Xuanwu Hospital, Capital Medical University; Institute of Vascular Surgery, Capital Medical University, Beijing, China.

Guo J, Guo L, Zeng G, Tong Z, Gao X, Gu Y. An infant case of renovascular hypertension in moyamoya disease treated by angioplasty. Turk J Pediatr 2018; 60: 331-334. Read More

Lancet 2018 11;392(10161):2298

Department of Medicine, Division of Nephrology, Hospital Costa del Sol, Marbella, Malaga, Spain.

Phytomedicine 2018 Dec 19;51:7-19. Epub 2018 May 19.

Laboratório de Eletrofisiologia e Farmacologia Cardiovascular, Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Rodovia Dourados-Itahum, km 12, P.O. Box 533, 79.804-970, Dourados, MS, Brazil. Electronic address:

Background: One of the medicinal plants widely used by the population in the treatment of hypertension, atherosclerosis and circulatory disorders is Cuphea carthagenensis (Jacq.) J.F. Read More

J Hum Genet 2019 Feb 16;64(2):177-181. Epub 2018 Nov 16.

Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan.

Schimmelpenning syndrome is a rare neurocutaneous disorder categorized as a mosaic RASopathy due to postzygotic HRAS or KRAS mutations. We report a 6-year-old girl diagnosed with Schimmelpenning syndrome due to a postzygotic KRAS G12D mutation. The patient had three atypical symptoms of Schimmelpenning syndrome: renovascular hypertension, congenital lipomatosis, and diabetes mellitus. Read More

BMJ Case Rep 2018 Nov 8;2018. Epub 2018 Nov 8.

Department of Cardiology, PGIMER, Chandigarh, India.

Renovascular hypertension is a common clinical presentation in Takayasu arteritis (TA), when the renal arteries are involved. Although most of the patients respond to optimal antihypertensive drug therapy, certain patients with TA require percutaneous or surgical renal artery revascularisation to manage renovascular hypertension. We, hereby, present a 45-year-old woman, who had resistant hypertension secondary to in-stent restenosis (ISR) of renal artery stent in a single functioning kidney. Read More

Clin Hypertens 2018 1;24:15. Epub 2018 Nov 1.

Department of Medicine, Sarawak General Hospital, Ministry of Health Malaysia, Jalan Hospital, 93586 Kuching, Sarawak Malaysia.

Background: Hypokalemia in the presence of hypertension is often attributed to primary hyperaldosteronism as a cause of secondary hypertension, however secondary hyperaldosteronism may present similarly. Accessory renal arteries are variants in the vascular anatomy which are often thought to be innocuous but in some circumstances can cause renovascular hypertension leading to secondary hyperaldosteronism.

Case Presentation: We report 2 cases of hypertension with secondary hyperaldosteronism associated with accessory renal arteries. Read More

Hypertens Res 2019 Jan 6;42(1):40-51. Epub 2018 Nov 6.

Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

It remains unknown which surrogate markers can predict diagnostic test results for primary hyperaldosteronism (PA). The Secondary Hypertension Registry Investigation in Mie Prefecture (SHRIMP) study has sequentially and prospectively recruited 128 patients with hypertension with an aldosterone-to-renin ratio (ARR) greater than 20, evaluated the differences among essential hypertension (EHT), idiopathic hyperaldosteronism (IHA), and aldosterone-producing adenoma (APA), and analyzed the predictors for the confirmatory tests. The patients underwent saline-loading, captopril-challenge, and upright furosemide-loading tests. Read More

Int J Rheum Dis 2019 Jan 5;22(1):140-151. Epub 2018 Nov 5.

Allergy Immunology Unit, Department of Paediatrics, Advanced Paediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Aim: To report our experience on complex percutaneous interventions of the abdominal aorta and its branches in six children with Takayasu arteritis (TA).

Methods: A review of records of children with TA, who underwent percutaneous interventions of the abdominal aorta and its major branches.

Results: In this analysis, we included six children with TA who underwent intervention of the abdominal aorta and its major branches. Read More

PLoS One 2018 31;13(10):e0206432. Epub 2018 Oct 31.

Neurosurgery of NeuroCenter, Kuopio University Hospital, and Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.

Background: Secondary hypertension is a serious form of hypertension, involving 5% to 10% of all hypertension patients. Hypertension is a risk factor of the saccular intracranial aneurysm (sIA) disease and subarachnoid hemorrhage from ruptured sIA (aSAH), but the impact of secondary hypertension on sIA disease is poorly known. In a defined Eastern Finnish sIA population we studied the prevalence of secondary hypertension and its impact on sIA disease phenotype. Read More

Cardiovasc Ther 2018 Dec 4;36(6):e12474. Epub 2018 Dec 4.

Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, Dundee, UK.

Background And Objective: Results of interventional trials in renovascular hypertension have been disappointing, and medical therapy is the current recommended gold standard. However, the comparative long-term benefits of different antihypertensive drug classes in atherosclerotic renal artery stenosis are not known. We aim to assess the effect of different antihypertensive drug classes on outcomes in renovascular hypertension DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: Using Tayside Health Informatics Centre database, anonymized data over a 6-year period was analyzed. Read More

Front Med (Lausanne) 2018 10;5:282. Epub 2018 Oct 10.

Laboratorio de Investigacao Medica 12 (LIM12), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

The pathogenesis of chronic kidney disease (CKD) involves a very complex interaction between hemodynamic and inflammatory processes, leading to glomerular/vascular sclerosis, and fibrosis formation with subsequent evolution to end-stage of renal disease. Despite efforts to minimize the progression of CKD, its incidence and prevalence continue to increase. Besides cardiovascular diseases and infections, several studies demonstrate that vitamin D status could be considered as a non-traditional risk factor for the progression of CKD. Read More