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J Ethnopharmacol 2020 May 21:112972. Epub 2020 May 21.

Department of Animal Biology and Physiology, Laboratory of Animal Physiology, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon. Electronic address:

Ethnopharmacological Relevance: Fagara tessmannii is a shrub of the African rainforests in South-West, Centre, South and East provinces in Cameroon. It is used in traditional medicine for the treatment of tumors, swellings, inflammation, gonorrhoea, schistosomiasis, antifungal, heart diseases and as anti-hypertensive.

Aim Of The Study: We investigated the potential effects of F. Read More

Hypertens Res 2020 May 22. Epub 2020 May 22.

Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Renal artery stenosis causes kidney ischemia, reducing the size of the affected kidney, which eventually results in atrophy. Although renal atrophy is considered irreversible, resolution of the ischemia occasionally restores kidney size when the cause is renal artery stenosis. Angioplasty is effective in patients with nonatherosclerotic renovascular diseases (non-ARVDs). Read More

BMJ Case Rep 2020 May 21;13(5). Epub 2020 May 21.

Department of Obstetrics and Gynecology, Cantonal Hospital Lucerne, Lucerne, Switzerland.

The midaortic syndrome (MAS) is a rare anomaly, characterised by narrowing of the distal aorta and its major branches. The most common symptom is severe arterial hypertension. The combination of hyponatremia, polyuria and renovascular hypertension caused by a unilateral renal artery stenosis is described as hyponatremic hypertensive syndrome. Read More

J Cell Physiol 2020 May 19. Epub 2020 May 19.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.

Effective therapeutic strategies are needed to preserve renal function in patients with atherosclerotic renal artery stenosis (ARAS). Low-energy shockwave therapy (SW) and adipose tissue-derived mesenchymal stem/stromal cells (MSCs) both stimulate angiogenesis repair of stenotic kidney injury. This study tested the hypothesis that intrarenal delivery of adipose tissue-derived MSCs would enhance the capability of SW to preserve stenotic kidney function and structure. Read More

Cureus 2020 Apr 9;12(4):e7609. Epub 2020 Apr 9.

Radiology, James H. Quillen Veterans Affairs Medical Center, Johnson City, USA.

Renal hypoperfusion from renal artery stenosis (RAS) activates the renin-angiotensin system, which in turn causes volume overload and hypertension. Atherosclerosis and fibromuscular dysplasia are the most common causes of renal artery stenosis. Recurrent flash pulmonary edema, also known as Pickering syndrome, is commonly associated with bilateral renal artery stenosis. Read More

Neuroscience 2020 Apr 27;437:98-106. Epub 2020 Apr 27.

Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, No. 58 Zhongshan Road 2, Guangzhou 510080, China. Electronic address:

We investigated whether intermittent theta burst stimulation (iTBS) can improve the spatial cognitive function of rats with hypertension-induced cerebral small vessel disease. To prove our hypothesis, stroke-prone renovascular hypertensive rats (RHRSPs) were treated with iTBS beginning at postoperative week 22. The Morris water maze was performed to assess spatial cognitive function. Read More

Neurosci Lett 2020 May 15;728:134976. Epub 2020 Apr 15.

Cardiovascular Division, Department of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil. Electronic address:

Previous studies have been described changes in brain regions contributing to the sympathetic vasomotor overactivity in Goldblatt hypertension (2K1C). Furthermore, changes in the spinal cord are also involved in the cardiovascular and autonomic dysfunction in renovascular hypertension, as intrathecal (i.t. Read More

Am J Physiol Heart Circ Physiol 2020 May 17;318(5):H1346-H1355. Epub 2020 Apr 17.

Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

Renovascular hypertension is characterized by activation of the renin-angiotensin-aldosterone system, blunted natriuretic responses, and elevated sympathetic nerve activity. Excess dietary salt intake exaggerates arterial blood pressure (ABP) in multiple models of experimental hypertension. The present study tested whether a high-salt diet exaggerated ABP and vascular dysfunction in a 2-kidney, 1-clip (2K1C) murine model. Read More

Cardiovasc Res 2020 Apr 13. Epub 2020 Apr 13.

Division of Cardiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200 Brussels, Belgium/Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, 1200 Brussels, Belgium.

Aims: Since December 2015, the European/International Fibromuscular Dysplasia (FMD) Registry enrolled 1022 patients from 22 countries. We present their characteristics according to disease subtype, age and gender, as well as predictors of widespread disease, aneurysms and dissections.

Methods And Results: All patients diagnosed with FMD (string-of-beads or focal stenosis in at least one vascular bed) based on CTA, MRA and/or catheter-based angiography were eligible. Read More

J Vasc Surg 2020 Apr 7. Epub 2020 Apr 7.

The Section of Vascular Surgery, Department of Surgery.

Objective: The pathologic nature of pediatric renal artery occlusive lesions causing renovascular hypertension has been the subject of numerous anecdotal reports. This study was undertaken to define the character of childhood renal artery stenoses. A better understanding of this disease is particularly germane given its unknown etiology and the limited success of certain contemporary treatment options. Read More

J Vasc Surg 2020 Apr 7. Epub 2020 Apr 7.

University of Michigan, Department of Surgery, Section of Vascular Surgery.

Introduction: Renovascular hypertension (RVH) associated with renal artery and abdominal aortic narrowings is the third most common cause of pediatric hypertension. Untreated children may experience major cardiopulmonary complications, stroke, renal failure and death. The impetus of this study was to describe the increasingly complex surgical practice for such patients with an emphasis on anatomic phenotype and contemporary outcomes following surgical management, as a means of identifying those factors responsible for persistent or recurrent hypertension necessitating reoperation. Read More

Khirurgiia (Mosk) 2020 (3):43-47

Kemerovo State Medical University of the Ministry of Health of Russia, Kemerovo, Russia.

Objective: A retrospective analysis of in-hospital results of renal artery stenting in patients with multifocal atherosclerosis.

Material And Methods: The study included 19 patients who underwent stenting for renal artery stenosis for the period 2011-2015 in the Kemerovo Cardiology Dispensary. Renal function was assessed considering glomerular filtration rate (GFR). Read More

Clin Hypertens 2020 1;26. Epub 2020 Apr 1.

1Department of Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, USA.

Background: Renal artery stenosis is a notorious cause of secondary hypertension which classically presents as chronic refractory hypertension, recurrent flash pulmonary edema or renal insufficiency after initiation of an angiotensin converting enzyme inhibitor. Rarely, there have been reported cases of pregnant patients presenting with new onset or superimposed preeclampsia secondary to renovascular hypertension. In this subset of patients, renovascular hypertension carries significantly higher risks including obstetric, fetal and medical emergencies and death. Read More

J Stroke Cerebrovasc Dis 2020 Mar 28:104786. Epub 2020 Mar 28.

Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan.

Background: The de novo occurrence of renal artery stenosis in renal arteries that were angiographically confirmed to be normal in the past has never been reported before in patients with moyamoya disease.

Case Description: During the long-term follow-up of pediatric patients with moyamoya disease, we observed 3 patients who developed de novo renal artery stenosis in arteries that had been angiographically confirmed to be normal 1 year after the surgery (7 years on average, ranging from 4 to 11 years). All of these patients were neurologically stable after successful indirect bypass surgery during childhood. Read More

Hypertension 2020 May 30;75(5):1205-1212. Epub 2020 Mar 30.

From the Department of Vascular Medicine (D.C., B.-J.H.v.d.B.), Amsterdam UMC, University of Amsterdam, The Netherlands.

Lowering blood pressure (BP) can lead to an initial decline in estimated glomerular filtration rate (eGFR). However, there is debate how much eGFR decline is acceptable. We performed a post hoc analysis of ACCORD-BP (Action to Control Cardiovascular Risk in Diabetes-Blood Pressure) and SPRINT (Systolic Blood Pressure Intervention Trial), which randomized patients to intensive or standard systolic BP-targets. Read More

Indian Pediatr 2020 May 12;57(5):443-451. Epub 2020 Mar 12.

Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Renovascular hypertension (RVHTN) is an important contributor to secondary etiologies of hypertension in the pediatric population. A delay in diagnosis can be associated with adverse outcomes. The etiologies of renal artery stenosis (RAS) vary from anatomical, inflammatory, genetic syndromes, intra-luminal, external compression and idiopathic. Read More

Clin Nephrol 2020 Jun;93(6):300-305

An elderly Japanese woman with bilateral renal artery occlusion who developed massive proteinuria after unilateral percutaneous transluminal renal angioplasty (PTRA) is reported. She had a history of percutaneous coronary intervention and subsequently developed refractory hypertension. She was diagnosed with renovascular hypertension caused by bilateral total occlusion of the renal arteries, and underwent PTRA for the left renal artery. Read More

J Tradit Chin Med 2019 08;39(4):542-549

Henan University of Chinese Medicine, Zhengzhou, 450046, China.

Objective: To investigate the inhibitory effect of chrysanthemum extract on myocardial fibrosis in rats with renovascular hypertension, and explore the possible mechanism underlying this effect.

Methods: Sixty Wistar rats were randomly divided into six groups: sham operation, model, positive control, and low-, medium-, and high-dose Huai chrysanthemum extract groups (ten rats per group). With the exception of the sham operation group, a renal hypertensive model was established in rats using the "two-kidney, one clip" method. Read More

Am J Hypertens 2020 Mar 17. Epub 2020 Mar 17.

Department of Internal Medicine, Division of Nephrology and Hypertension, Rochester, MN.

Background: Mitochondria modulate several aspects of endothelial cell (EC) function, but may be damaged during renal disease. We hypothesized that the ischemic and metabolic constituents of swine renovascular disease (RVD) induce mitochondrial damage and impair the function of renal artery ECs.

Methods: Domestic pigs were studied after 16 weeks of diet-induced metabolic syndrome (MetS), renal artery stenosis (RAS), or coexisting MetS and RAS, and Lean pigs served as control (n=6 each). Read More

Life Sci 2020 Jun 13;250:117549. Epub 2020 Mar 13.

Departamento de Ciências Biológicas, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brasil; Núcleo de Pesquisa em Ciências Biológicas-Programa de Pós-Graduação em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil; Departamento de Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil. Electronic address:

Aim: To evaluate physical fitness and cardiovascular effects in rats with renovascular hypertension, two kidneys, one clip (2K1C) submitted to voluntary exercise (ExV).

Main Methods: 24 h after surgery (SHAM and 2K1C) rats were submitted to ExV for one week (adaptation). ExV adherent rats were separated into exercise (2K1C-EX and SHAM-EX) or sedentary (2K1C-SED and SHAM-SED) groups. Read More

J Clin Hypertens (Greenwich) 2020 Apr 16;22(4):678-682. Epub 2020 Mar 16.

Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada.

Drug-induced hypertension is one of the commonest causes of secondary hypertension. In the last few years, secondary hypertension due to tyrosine kinase inhibitors, from the vascular endothelial growth factor class, has been recognized to be an important cause of hypertension, as well as proteinuria, and occasionally kidney dysfunction in some cases. Less well-recognized is that BCR-ABL tyrosine kinase inhibitors also have adverse vascular effects. Read More

Front Pediatr 2020 27;8:72. Epub 2020 Feb 27.

Department of Paediatrics, Medical School, Comenius University and National Institute of Children's Diseases, Bratislava, Slovakia.

Myhre syndrome is a rare condition caused by a mutation in the gene, which leads to a defective TGF-β/BMP signaling, resulting in the proliferation of abnormal fibrous tissues. Clinically, patients with Myhre syndrome manifest with defects of connective tissue (skin, muscles, joints), and cardiovascular and neurological impairment. In our report, we present a case of a 16-year-old female with skeletal abnormalities, reduced articular mobility, skin, and muscular hypertrophy and cardiovascular defects characteristic of Myhre syndrome. Read More

Pediatr Int 2020 Mar 10. Epub 2020 Mar 10.

Division of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan.

Background: Despite advances in noninvasive vascular imaging, detection of renal artery stenosis via catheter angiography is the gold standard for the diagnosis of renovascular hypertension (RVH). Due to lack of evidence, the utility of various blood tests and imaging modalities remains unclear.

Methods: We retrospectively analyzed the utility of blood tests [plasma renin activity (PRA), aldosterone, and renal vein renin values] and imaging studies [computed tomography (CT) angiography, kidney ultrasonography (US)] by comparing them with renal angiography. Read More

Hypertension 2020 Apr 9;75(4):1102-1109. Epub 2020 Mar 9.

From the Departments of Hypertension (E.W.-C., A.P., P.D., E.F., K.J.-P., M.K., M.P., K.H., P.T., M.S., K.K., A.J.), Institute of Cardiology, Warsaw, Poland.

Fibromuscular dysplasia (FMD), regarded as a generalized vascular disease, may affect all vascular beds and may result in arterial stenosis, occlusion, aneurysm, or dissection. It has been proposed to systematically evaluate all vascular beds in patients with FMD, regardless of initial FMD involvement. However, the impact of this approach on clinical decisions and on management is unknown. Read More

Interv Cardiol Clin 2020 04 31;9(2):169-185. Epub 2020 Jan 31.

Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Center, Ochsner Medical Center, The Ochsner Clinical School, University of Queensland, 1514 Jefferson Highway, New Orleans, LA 70121, USA; Department of Cardiology, Ochsner Medical Center, 3rd Floor, 1514 Jefferson Highway, New Orleans, LA 70121, USA. Electronic address:

Atherosclerotic renal artery stenosis is the most common cause of secondary hypertension and may cause progressive renal disease and cardiac destabilization syndromes. Guideline-directed medical therapy is advised in all patients. Patients with refractory symptoms and hemodynamically significant stenoses are more likely to benefit from renal artery stent placement. Read More

J Vasc Surg 2020 Mar 2. Epub 2020 Mar 2.

Division of Vascular and Endovascular Surgery, Department of Surgery, Keck School of Medicine at the University of Southern California, Los Angeles, Calif.

Objective: The Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL) trial, a multicenter randomized controlled trial, failed to demonstrate a benefit of renal artery stenting (RAS) over medical therapy in patients with renal artery stenosis and hypertension. However, there are patients for whom RAS is a consideration because of failure of medical therapy. Unfortunately, selection of patients for RAS is complicated by a lack of validated predictors of blood pressure (BP) response. Read More

Rev Port Cardiol 2019 12 2;38(12):869-871. Epub 2020 Mar 2.

Serviço de Nefrologia do Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental, Carnaxide, Portugal. Electronic address:

Case Rep Vasc Med 2020 11;2020:4726381. Epub 2020 Feb 11.

Cardiovascular Surgery Department, Yamanashi Prefectural Central Hospital, 400-8506, Japan.

Both spontaneous superior mesenteric artery dissection (SMAD) and spontaneous renal artery dissection (SRAD) are very rare conditions. Their etiologies and natural histories are not precisely defined, but they are thought to be associated with underlying conditions. In this report, we describe an extremely rare case of SRAD in a man who had a history of spontaneous SMAD. Read More

Kidney Int 2020 Apr 13;97(4):793-804. Epub 2019 Dec 13.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:

Atherosclerotic renovascular disease (ARVD) reduces tissue perfusion and eventually leads to loss of kidney function with limited therapeutic options. Here we describe results of Phase 1a escalating dose clinical trial of autologous mesenchymal stem cell infusion for ARVD. Thirty-nine patients with ARVD were studied on two occasions separated by three months. Read More

Medicines (Basel) 2020 Feb 20;7(2). Epub 2020 Feb 20.

Department of Pediatrics, Division of Pediatric Nephrology, University of Florida, Gainesville, FL 32610, USA.

: Fibromuscular dysplasia (FMD) is one of the important etiologies of renovascular hypertension in children. It is usually resistant to multiple antihypertensive agents and can cause extreme elevation in blood pressures, which can lead to end organ damage if not promptly diagnosed and treated. Treatment options include medical management with antihypertensive agents, balloon or stent angioplasties, surgical revascularization, and nephrectomy. Read More

Cureus 2020 Feb 11;12(2):e6960. Epub 2020 Feb 11.

Cardiology, St. Elizabeth's Medical Center / Tufts University School of Medicine, Brighton, USA.

Isolated renal artery dissection (IRAD) is a rare and often unrecognized clinical entity, with a paucity of data on its epidemiology and management. We extracted 129 cases of IRAD from the medical literature between 1972 and 2016. IRAD as a result of an extended dissection from the aorta and splanchnic or mesenteric arteries was excluded. Read More

Curr Opin Cardiol 2020 May;35(3):249-257

Experimental and Clinical Research Center (ECRC), A joint cooperation between the Max-Delbrück Center of Molecular Medicine and the Charité Medical Faculty.

Purpose Of Review: Genetic variance on blood pressure was shown about 100 years ago; a Mendelian inheritance was initially presumed. Platt and Pickering conducted a lively debate, whether blood pressure was inherited in a Mendelian fashion or whether the condition was polygenic. Genetic-hypertension research has appropriately followed both pathways. Read More

J Control Release 2020 May 14;321:442-462. Epub 2020 Feb 14.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA; Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein 2028, South Africa. Electronic address:

The application of nanotechnology in medicine has the potential to make a great impact on human health, ranging from prevention to diagnosis and treatment of disease. The kidneys are the main organ of the human urinary system, responsible for filtering the blood, and concentrating metabolic waste into urine by means of the renal glomerulus. The glomerular filtration apparatus presents a barrier against therapeutic agents based on charge and/or molecular size. Read More

Hypertens Res 2020 Feb 14. Epub 2020 Feb 14.

Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, 3010, Australia.

There is evidence to suggest that hypertension involves a chronic low-grade systemic inflammatory response; however, the underlying mechanisms are unclear. To further understand the role of inflammation in hypertension, we used a rat renovascular model of hypertension in which we administered the TNF-α synthesis inhibitor pentoxifylline (PTX, 30 mg/kg/day) in the drinking water for 60 days. In conscious rats, PTX administration significantly attenuated the development of hypertension (systolic blood pressure, PTX: 145 ± 8 vs. Read More

Iran J Med Sci 2020 Jan;45(1):41-49

Cardiovascular Pharmacology Research Lab, Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Liposomes constitute a promising drug delivery vehicle, and are believed to improve drugs' effectiveness. This study was aimed to compare antihypertensive and vascular modifying activities of liposomal and non-liposomal forms of ascorbic acid.

Methods: Forty-nine male Sprague-Dawley rats were randomly divided into seven groups (n=7): A sham vehicle-receiving (Sham-veh), hypertensive (HTN), vehicle-receiving hypertensive (HTN-Veh), two liposomal Ascorbic acid-treated hypertensive at 50 or 100 mg/kg/day (LVC-50 and LVC-100), and two non-liposomal Ascorbic acid-treated hypertensive at 50 or 100 mg/kg/day (VC-50 and VC-100). Read More

Pflugers Arch 2020 03 5;472(3):323-324. Epub 2020 Feb 5.

Dobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit / Medical Research Foundation, University of Western Australia, Level 3, MRF Building, Rear 50 Murray St, Perth, WA, 6000, Australia.

Am J Physiol Regul Integr Comp Physiol 2020 Apr 5;318(4):R730-R742. Epub 2020 Feb 5.

Department of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.

The two kidney-one clip (2K1C) renovascular hypertension depends on the renin-angiotensin system and sympathetic overactivity. The maintenance of 2K1C hypertension also depends on inputs from the carotid bodies (CB), which when activated stimulate the respiratory activity. In the present study, we investigated the importance of CB afferent activity for the ventilatory responses in 2K1C hypertensive rats and for phrenic and hypoglossal activities in in situ preparations of normotensive rats treated with angiotensin II. Read More

Rev Med Suisse 2020 Feb;16(680):272-274

Service de néphrologie, Hôpital de la Tour, Avenue J.-D. Maillard 3, 1217 Meyrin.

Renal artery stenosis can lead to renovascular secondary hypertension. It can also induce an elevation of creatinine, but usually in the case of bilateral stenosis. In addition, it may be associated with the occurrence of heart failure and pulmonary edema. Read More

Am J Hypertens 2020 Apr;33(5):391-401

Department of Medicine, Katta General Hospital, Shiroishi, Japan.

Atherosclerotic renal artery stenosis (ARAS) can cause secondary hypertension, progressive decline in renal function, and cardiac complications. Recent randomized controlled trials including the Cardiovascular Outcomes in Renal Atherosclerotic Lesions study have not reported the benefit of renal artery stenting compared with medical therapy alone to improve renal function or reduce cardiovascular and renal events in the enrolled patients with ARAS. However, observational evidence indicating the benefits of angioplasty in the selected high-risk patients with ARAS has been increasing. Read More

BMC Nephrol 2020 Jan 29;21(1):29. Epub 2020 Jan 29.

Departments of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Background: Transplant renal artery dissection is a rare and serious event that can cause allograft dysfunction and activation of the renin-mediated renovascular hypertension. Most cases are induced by percutaneous transluminal angioplasty, arteriosclerotic disease, or fibromuscular dysplasia. We observed a case of transplant renal artery dissection induced by unusual causes during kidney transplantation. Read More

Turk J Pediatr 2019 ;61(4):629-634

Departments of Medical Imaging, Changhua Christian Children's Hospital, Changhua.

Lee ML, Chang TM, Yang RC, Yang AD, Chen M. Systemic hypertension followed by insidious stroke in a 12-year-old boy with childhood neurofibromatosis type 1 presenting with renal and cerebral artery vasculopathy. Turk J Pediatr 2019; 61: 629-634. Read More

Catheter Cardiovasc Interv 2020 Feb 13;95 Suppl 1:641-647. Epub 2020 Jan 13.

Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objectives: This study aimed to evaluate the safety and efficiency of percutaneous transluminal angioplasty (PTA) with selective stenting treating Chinese patients with renal artery stenosis (RAS) due to fibromuscular dysplasia (FMD).

Background: Endovascular data of patients with RAS caused by FMD are scarce in China.

Methods: Clinical data of 105 hypertensive patients with RAS caused by FMD underwent endovascular therapy at a single-site between June 2001 and October 2018 were analyzed retrospectively. Read More

Basic Res Cardiol 2020 01 14;115(2):16. Epub 2020 Jan 14.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, 55905, USA.

Extracellular vesicles (EVs) deliver genes and proteins to recipient cells, and mediate paracrine actions of their parent cells. Intrarenal delivery of mesenchymal stem cell (MSC)-derived EVs preserves stenotic-kidney function and reduces release of pro-inflammatory cytokines in a swine model of coexisting metabolic syndrome (MetS) and renal artery stenosis (RAS). We hypothesized that this approach is also capable of blunting cardiac injury and dysfunction. Read More

J Cardiol Cases 2020 Jan 27;21(1):28-31. Epub 2019 Sep 27.

Department of Pediatrics Jichi Medical University School of Medicine, Tochigi, Japan.

Background: Alagille syndrome (ALGS) is characterized by cholestasis due to paucity of intrahepatic bile ducts, cardiac anomalies, ophthalmologic abnormalities, skeletal abnormalities, and characteristic facies. Mid-aortic syndrome (MAS) is a rare entity characterized by segmental narrowing of the proximal abdominal aorta and ostial stenosis of its major branches. We report a case of ALGS with MAS involving severe renal artery stenosis (RAS). Read More

Pflugers Arch 2020 03 10;472(3):325-334. Epub 2020 Jan 10.

Department of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo - Escola Paulista de Medicina (UNIFESP-EPM), São Paulo, Brazil.

The ablation of renal nerves, by destroying both the sympathetic and afferent fibers, has been shown to be effective in lowering blood pressure in resistant hypertensive patients. However, experimental studies have reported that the removal of sympathetic fibers may lead to side effects, such as the impairment of compensatory cardiorenal responses during a hemodynamic challenge. In the present study, we evaluated the effects of the selective removal of renal afferent fibers on arterial hypertension, renal sympathetic nerve activity, and renal changes in a model of renovascular hypertension. Read More

Transplant Proc 2020 Jan - Feb;52(1):153-156. Epub 2020 Jan 7.

Royal North Shore Hospital Department of Renal Medicine, Sydney Australia; University of Sydney, Sydney Australia.

Background: We present a first case of orthostatic renal graft compression and acute kidney injury following weight gain.

Case Report: A 61-year-old male with a second cadaveric transplant presented with acute kidney injury - creatinine rise from 80 to 210 μmol/L (0.90 to 2. Read More

Iran J Kidney Dis 2019 11;13(6):362-371

Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Renovascular hypertension is known to occur due to varied causes. Absence of Renal artery stenosis or changes in renal vascular flow make it tough to establish a diagnosis of renovascular hypertension in the absence of invasive investigations. Segmental renal hypoplasia is not only a rare cause for renin mediated hypertension but also requires expertise and high index of suspicion while evaluating children with hypertension. Read More

World Neurosurg 2020 Apr 21;136:e158-e164. Epub 2019 Dec 21.

Division of Pediatric Neurosurgery, Department of Neurosurgery, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: Indirect bypass surgery is used to improve the hemodynamic status of pediatric patients with moyamoya disease (MMD). Symptomatic cerebral infarction during the early postoperative period may be the most frustrating complication. This study was conducted to investigate the factors associated with early postoperative symptomatic cerebral infarction. Read More

J Neurosurg 2019 Dec 20:1-13. Epub 2019 Dec 20.

1Department of Neurosurgery, National Hospital Organization Kyoto Medical Center, Kyoto.

Objective: There are no effective therapeutic drugs for cerebral aneurysms, partly because the pathogenesis remains unresolved. Chronic inflammation of the cerebral arterial wall plays an important role in aneurysm formation, but it is not clear what triggers the inflammation. The authors have observed that vascular endothelial P2X4 purinoceptor is involved in flow-sensitive mechanisms that regulate vascular remodeling. Read More