33,100 results match your criteria Renal Transplantation Medical


Early clear cell "sugar" lung cancer management: A case report and a brief literature review.

Thorac Cancer 2019 Apr 16. Epub 2019 Apr 16.

UOC of Oncology, University of Rome, Aprilia, Italy.

A clear cell tumor is a histological entity that rarely originates outside of the kidney. We describe a rare case of a clear cell tumor of the lung, also known as "sugar cancer," that occurred in a 74 year-old male patient, and perform a brief literature review. This report highlights the importance of an adequate disease management team, including surgeons, oncologists, and pathologists, to identify the best therapeutic approach to improve survival rates and the quality of life of patients affected by this rare disease. Read More

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http://dx.doi.org/10.1111/1759-7714.13077DOI Listing

Absolute basophil count is associated with time to recurrence in patients with high-grade T1 bladder cancer receiving bacillus Calmette-Guérin after transurethral resection of the bladder tumor.

World J Urol 2019 Apr 16. Epub 2019 Apr 16.

Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.

Background: Basophils, eosinophils and monocytes may be involved in BCG-induced immune responses and be associated with outcomes of bladder cancer patients receiving intravesical BCG. Our objective was to explore the association of baseline counts of basophils, eosinophils and monocytes with outcomes of patients with high-grade T1 bladder cancer receiving a standard course of intravesical BCG.

Methods: We retrospectively reviewed medical records of patients with primary T1 HG/G3 bladder cancer. Read More

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http://dx.doi.org/10.1007/s00345-019-02754-2DOI Listing

Safety and Efficacy of Reduced Prolonged-release Tacrolimus Exposure in De Novo Kidney Transplantation: A Randomized, Open-label, Pilot Study in Asia-OPTIMIZE Study.

Transplant Direct 2019 Apr 25;5(4):e340. Epub 2019 Mar 25.

Division of Kidney and Pancreas Transplant, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Background: A multicenter, randomized, open-label, parallel group, pilot, 52-week study in Asian countries that assessed the renal function, efficacy, and safety of reduced-exposure versus standard-exposure prolonged-release tacrolimus (PR-T) in adult kidney transplant recipients (KTRs).

Methods: Posttransplantation, KTRs received PR-T from weeks 0 to 4 (initial dose, 0.2-0. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445651PMC

Checkpoint inhibitor therapy for cancer in solid organ transplantation recipients: an institutional experience and a systematic review of the literature.

J Immunother Cancer 2019 Apr 16;7(1):106. Epub 2019 Apr 16.

Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Checkpoint inhibitors (CPIs) have revolutionized the treatment of cancer, but their use remains limited by off-target inflammatory and immune-related adverse events. Solid organ transplantation (SOT) recipients have been excluded from clinical trials owing to concerns about alloimmunity, organ rejection, and immunosuppressive therapy. Thus, we conducted a retrospective study and literature review to evaluate the safety of CPIs in patients with cancer and prior SOT. Read More

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http://dx.doi.org/10.1186/s40425-019-0585-1DOI Listing

The Current Status and Future of Peritoneal Dialysis in Japan.

Contrib Nephrol 2019 16;198:78-86. Epub 2019 Apr 16.

Department of General Internal Medicine, Saitama Medical University, Saitama, Japan,

Background: Recent reports have outlined the present conditions and future prospects of Japanese patients on dialysis. Japan currently has the most rapidly aging population in the world and its dialysis population is also aging rapidly.

Summary: Patients on dialysis in Japan have an extremely good prognosis, probably because of the national health insurance system with efficient introduction of patients to dialysis, creation of a good arteriovenous shunt, an adequate patient education system, management by skilled medical, nursing, and technical staff, and good hygiene. Read More

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https://www.karger.com/Article/FullText/496529
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http://dx.doi.org/10.1159/000496529DOI Listing
April 2019
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Pilot Experience with ABO-Incompatible Kidney Transplantation as a Second Transplant.

Urol Int 2019 Apr 16:1-8. Epub 2019 Apr 16.

Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background: Despite advances in immunosuppressant medications, improvement in long-term survival for kidney transplant recipients has been more difficult to achieve. In fact, the number of patients with failing grafts who must either return to dialysis or undergo a second transplant is increasing. Second transplantation is associated with reduced mortality rates compared to remaining on dialysis after an initial graft loss. Read More

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https://www.karger.com/Article/FullText/499490
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http://dx.doi.org/10.1159/000499490DOI Listing
April 2019
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The Role of Uric Acid in Acute Kidney Injury.

Nephron 2019 Apr 16:1-9. Epub 2019 Apr 16.

Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida, USA.

Studies have demonstrated the presence of a strong association between serum uric acid (SUA) and acute kidney injury (AKI) consistently across several disease models. Exposure to SUA at different time periods and concentrations has reliably resulted in AKI whether assessed by conventional or novel biomarkers or by kinetic estimated glomerular filtration rate (KeGFR) engineered for non-steady dynamic states. In experimental models, moderate hyperuricemia was associated with an absence of intrarenal crystals, manifestation of tubular injury, macrophage infiltration, and increased expression of inflammatory mediators that were attenuated with uric acid lowering therapy with rasburicase, a recombinant urate oxidase. Read More

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http://dx.doi.org/10.1159/000499939DOI Listing

Oxalate deposition in renal allograft biopsies within 3 months after transplantation is associated with allograft dysfunction.

PLoS One 2019 16;14(4):e0214940. Epub 2019 Apr 16.

Rotterdam Transplant Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Calcium oxalate (CaOx) deposition in the kidney may lead to loss of native renal function but little is known about the prevalence and role of CaOx deposition in transplanted kidneys.

Methods: In patients transplanted in 2014 and 2015, all for-cause renal allograft biopsies obtained within 3 months post-transplantation were retrospectively investigated for CaOx deposition. Additionally, all preimplantation renal biopsies obtained in 2000 and 2001 were studied. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214940PLOS

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy.

N Engl J Med 2019 Apr 14. Epub 2019 Apr 14.

From the George Institute for Global Health, University of New South Wales Sydney (V.P., M.J.J., B.N., S. Bompoint), the Royal North Shore Hospital (V.P.), Concord Repatriation General Hospital (M.J.J.), and the Charles Perkins Centre, University of Sydney (B.N.), Sydney, and the Kolling Institute of Medical Research, Sydney Medical School, University of Sydney, Royal North Shore Hospital, St. Leonards, NSW (C.P.) - all in Australia; Imperial College London (B.N.) and the Department of Renal Medicine, UCL Medical School (D.C.W.) - both in London; the Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands (H.J.L.H., D.Z.); the Nephrology Division, NYU School of Medicine and NYU Langone Medical Center, New York (D.M.C.); Baim Institute for Clinical Research (D.M.C., C.P.C., B.M.B.), the Cardiovascular Division (C.P.C.) and the Renal Division and Department of Medicine (B.M.B), Brigham and Women's Hospital, and Harvard Medical School (B.M.B.) - all in Boston; Janssen Research and Development, Raritan, NJ (R.E., S. Bull, G.C., P.-L.C., Y.Y., G.M.); Indiana University School of Medicine and Veterans Affairs Medical Center, Indianapolis (R.A.); the Department of Medicine, University of Chicago Medicine, Chicago (G.B.); the Division of Biostatistics, Department of Population Health Sciences, University of Utah, Salt Lake City (T.G.); the Division of Nephrology, University of British Columbia, Vancouver (A.L.), and the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto (B.Z.) - all in Canada; the Renal Division, Peking University First Hospital, Beijing (H.Z.); and the Stanford Center for Clinical Research, Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.).

Background: Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium-glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes.

Methods: In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1811744
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http://dx.doi.org/10.1056/NEJMoa1811744DOI Listing
April 2019
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Acute Tubular Injury is Associated With Severe Traumatic Brain Injury: in Vitro Study on Human Tubular Epithelial Cells.

Sci Rep 2019 Apr 15;9(1):6090. Epub 2019 Apr 15.

Department of Anesthesia and Intensive Care, University of Turin, Città della Salute e della Scienza - Molinette University Hospital, Turin, Italy.

Acute kidney injury following traumatic brain injury is associated with poor outcome. We investigated in vitro the effects of plasma of brain injured patients with acute tubular kidney injury on kidney tubular epithelial cell function. we performed a prospective observational clinical study in ICU in a trauma centre of the University hospital in Italy including twenty-three ICU patients with traumatic brain injury consecutively enrolled. Read More

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http://dx.doi.org/10.1038/s41598-019-42147-4DOI Listing

Low-dose agalsidase beta treatment in male pediatric patients with Fabry disease: A 5-year randomized controlled trial.

Mol Genet Metab 2019 Apr 3. Epub 2019 Apr 3.

Department of Pediatric Metabolic Diseases, Emma Children's Hospital and Amsterdam Lysosome Center "Sphinx", Academic Medical Center, University Hospital of Amsterdam, Amsterdam, the Netherlands.

Background: Fabry disease is a rare, X-linked, lifelong progressive lysosomal storage disorder. Severely deficient α-galactosidase A activity in males is associated with the classic phenotype with early-onset, multisystem manifestations evolving to vital organ complications during adulthood. We assessed the ability of 2 low-dose agalsidase beta regimens to lower skin, plasma, and urine globotriaosylceramide (GL-3) levels, and influence clinical manifestations in male pediatric Fabry patients. Read More

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http://dx.doi.org/10.1016/j.ymgme.2019.03.010DOI Listing

Diagnostic and prognostic roles of CK20 in the pathology of urothelial lesions. A systematic review.

Pathol Res Pract 2019 Apr 6. Epub 2019 Apr 6.

Urology and Renal Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.

Cytokeratin 20 (CK20) is one of the most common immunohistochemical markers in the routine practice of a pathology lab, as biopsies from the urinary tract encompass a wide spectrum of lesions which may pose issues in their detection and classification. In this review, we aim to outline the diagnostic accuracy and prognostic value of CK20 in flat urothelial lesions, papillary non-invasive and invasive urothelial carcinoma, molecular subgroups and variant histology, and we briefly discuss its limitations and potential pitfalls. Read More

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http://dx.doi.org/10.1016/j.prp.2019.04.005DOI Listing

Plasma Malondialdehyde and Risk of New-Onset Diabetes after Transplantation in Renal Transplant Recipients: A Prospective Cohort Study.

J Clin Med 2019 Apr 4;8(4). Epub 2019 Apr 4.

Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.

New-onset diabetes after transplantation (NODAT) is a frequent complication in renal transplant recipients (RTR). Although oxidative stress has been associated with diabetes mellitus, data regarding NODAT are limited. We aimed to prospectively investigate the long-term association between the oxidative stress biomarker malondialdehyde (measured by high-performance liquid chromatography) and NODAT in an extensively phenotyped cohort of non-diabetic RTR with a functioning graft ≥1 year. Read More

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http://dx.doi.org/10.3390/jcm8040453DOI Listing

No correlation between Torque Teno virus viral load and BK virus replication after kidney transplantation.

J Clin Virol 2019 Apr 1;116:4-6. Epub 2019 Apr 1.

Department of Virology, Amiens University Medical Center, Amiens, France; AGIR Research Unit, EA4294, Jules Verne University of Picardie, Amiens, France. Electronic address:

Background: Assessment of the intensity of immunosuppression in transplant recipients to estimate the risk of rejection and infection is not entirely satisfactory at the present time. Determination of Torque teno virus (TTV) viral load appears to be a promising tool in this setting.

Objectives: We evaluated the level of replication and kinetics of TTV during the first three months after kidney transplantation compared to BK virus replication. Read More

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http://dx.doi.org/10.1016/j.jcv.2019.03.018DOI Listing

Membranous Nephropathy Post-Transplantation: An Update of the Pathophysiology and Management.

Transplantation 2019 Apr 10. Epub 2019 Apr 10.

Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Membranous nephropathy (MN) is a common cause of nephrotic syndrome after transplantation and is associated with an increased risk of allograft loss. MN may occur either as a recurrent or as a de novo disease. As in native kidneys, the pathophysiology of the MN recurrence is in most cases associated with anti-phospholipid A2 receptor antibodies (antiPLA2R). Read More

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http://dx.doi.org/10.1097/TP.0000000000002758DOI Listing
April 2019
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The impact of preexisting and posttransplant diabetes mellitus on outcomes following liver transplantation.

Transplantation 2019 Apr 10. Epub 2019 Apr 10.

Multiorgan Transplant Program, Toronto General Hospital, University of Toronto, Toronto, Canada.

Background: Diabetes mellitus (DM) is said to adversely affect transplant outcomes. The aim of this study was to investigate the impact of preexisting and new-onset DM on liver transplant (LT) recipients.

Method: A single-center retrospective analysis of prospectively collected data of LT recipients (1990-2015) was undertaken. Read More

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http://dx.doi.org/10.1097/TP.0000000000002757DOI Listing
April 2019
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An overview of the mechanisms in vascular calcification during chronic kidney disease.

Curr Opin Nephrol Hypertens 2019 Apr 9. Epub 2019 Apr 9.

Institute for Physiology and Pathophysiology, Johannes Kepler University Linz, Linz, Austria.

Purpose Of Review: Chronic kidney disease (CKD) facilitates a unique environment to strongly accelerate vascular calcification - the pathological deposition of calcium-phosphate in the vasculature. These calcifications are associated with the excessive cardiovascular mortality of CKD patients.

Recent Findings: Vascular calcification is a multifaceted active process, mediated, at least partly, by vascular smooth muscle cells. Read More

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http://dx.doi.org/10.1097/MNH.0000000000000507DOI Listing
April 2019
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Increased microvascular disease in X-linked and autosomal recessive Alport syndrome: a case control cross sectional observational study.

Ophthalmic Genet 2019 Apr 15:1-6. Epub 2019 Apr 15.

a Department of Medicine , Royal Melbourne Hospital, The University of Melbourne , Parkville , Australia.

Background: Retinal microvascular disease reflects, in part, poor blood pressure control and systemic microvascular disease contributes to renal failure progression. This study examined the retinal microvasculature in Alport syndrome.

Materials And Methods: Retinal images from 28 males and 28 females with X-linked Alport syndrome, and 13 individuals with autosomal recessive disease were reviewed retrospectively for microvascular/ hypertensive retinopathy (Wong and Mitchell classification), and small vessel calibre (using a computerised semiautomated method and revised Knudtson formula). Read More

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http://dx.doi.org/10.1080/13816810.2019.1589528DOI Listing

Cardiovascular disease in the kidney transplant recipient: epidemiology, diagnosis and management strategies.

Nephrol Dial Transplant 2019 Apr 15. Epub 2019 Apr 15.

Weill Cornell Medicine-New York Presbyterian Hospital, New York, NY, USA.

Kidney transplantation (KT) is the optimal therapy for end-stage kidney disease (ESKD), resulting in significant improvement in survival as well as quality of life when compared with maintenance dialysis. The burden of cardiovascular disease (CVD) in ESKD is reduced after KT; however, it still remains the leading cause of premature patient and allograft loss, as well as a source of significant morbidity and healthcare costs. All major phenotypes of CVD including coronary artery disease, heart failure, valvular heart disease, arrhythmias and pulmonary hypertension are represented in the KT recipient population. Read More

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https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt
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http://dx.doi.org/10.1093/ndt/gfz053DOI Listing
April 2019
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Unusual Presentation of Hemophagocytic Lymphohistiocytosis in a Kidney Transplant Patient.

Case Rep Transplant 2019 10;2019:3682378. Epub 2019 Mar 10.

Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

We are presenting a case of a middle-aged woman with history of remote kidney transplantation who had multiple admissions for septic shock-like picture, recurrent fever, and hypotension. Her shock manifestation would resolve after stress dose steroid administration and less than 24 hours of vasopressor administration. Initially, extensive workup was performed without revealing etiology. Read More

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http://dx.doi.org/10.1155/2019/3682378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431471PMC

Risk Factors for Developing Nonmelanoma Skin Cancer after Lung Transplantation.

J Skin Cancer 2019 10;2019:7089482. Epub 2019 Mar 10.

Department of Dermatology and Allergy, Skin Cancer Center Hannover, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

Background: Nonmelanoma skin cancer (NSMC) is the most common malignancy after organ transplantation. Lung transplant recipients (LTRs) are particularly prone to develop NMSC as compared to renal or hepatic transplant recipients due to higher dosages of immunosuppression needed. Everolimus, an immunosuppressant used in organ transplant recipients, is thought to inherit a lower risk for NMSC than calcineurin inhibitors, especially in renal transplant recipients. Read More

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http://dx.doi.org/10.1155/2019/7089482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431522PMC
March 2019
2 Reads

C1q Nephropathy in a Patient of Neurofibromatosis Type 1: A Rare Case Report.

Indian J Nephrol 2019 Mar-Apr;29(2):125-127

Department of Nephrology and Transplantation Medicine, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases and Research Centre - Dr. H.L. Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat, India.

C1q nephropathy is a rare glomerular disease defined by the presence of characteristic mesangial dominant or codominant C1q deposition on immunofluorescence microscopy. Neurofibromatosis type 1 (NF-1) is an autosomal dominant syndrome caused by a mutation of a gene located on chromosomal segment 17q11.2. Read More

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http://www.indianjnephrol.org/preprintarticle.asp?id=252208
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http://dx.doi.org/10.4103/ijn.IJN_353_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440327PMC
April 2019
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Extranasal extranodal NK/T cell lymphoma: A post-transplantation lymphoproliferative disease.

Int Wound J 2019 Apr 14. Epub 2019 Apr 14.

Department of Dermatology, Medical Faculty, Ege University, Izmir, Turkey.

Extranodal NK/T cell lymphoma (ENKTL) is a rare form of non-Hodgkin lymphoma. It mostly occurs in the upper respiratory tract. Cutaneous involvement can be seen among the extranasal ENKTLs. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/iwj.13126
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http://dx.doi.org/10.1111/iwj.13126DOI Listing
April 2019
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Big science and big data in nephrology.

Kidney Int 2019 Mar 5. Epub 2019 Mar 5.

RWTH Aachen, Department of Nephrology and Clinical Immunology, Aachen, Germany; Department of Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address:

There have been tremendous advances during the last decade in methods for large-scale, high-throughput data generation and in novel computational approaches to analyze these datasets. These advances have had a profound impact on biomedical research and clinical medicine. The field of genomics is rapidly developing toward single-cell analysis, and major advances in proteomics and metabolomics have been made in recent years. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.048DOI Listing

Outcomes after Peripancreatic Fluid Drainage in Patients with Simultaneous Pancreas Kidney Transplantation.

J Vasc Interv Radiol 2019 Apr 11. Epub 2019 Apr 11.

Department of Radiology and Biomedical Imaging, San Francisco, 505 Parnassus Ave, M-361, San Francisco, CA 94143. Electronic address:

Purpose: To determine the clinical outcomes of patients who underwent image-guided drainage of peripancreatic fluid collections after simultaneous pancreas-kidney (SPK) transplantation.

Materials And Methods: A retrospective review of all patients who underwent peripancreatic fluid collection drainage after SPK, from January 2000 to August 2017, at a single institution was performed. Patient characteristics, surgical technique, medication regimen, microbial analysis, and clinical outcomes were reviewed. Read More

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http://dx.doi.org/10.1016/j.jvir.2018.10.030DOI Listing

APOL1 Genetic Testing in Living Kidney Transplant Donors.

Am J Kidney Dis 2019 Apr 11. Epub 2019 Apr 11.

Division of General Medical Sciences, Washington University School of Medicine, St. Louis, MO.

The presence of 2 apolipoprotein L1 gene (APOL1) risk variants is associated with increased risk for chronic kidney disease and end-stage kidney disease. Inferior allograft outcomes following transplantation with kidneys from donors with 2 risk variants have also been reported. These data, coupled with anecdotal case reports and a recent cohort study of living donors, raise important questions about the potential increased kidney disease risk for living donors with APOL1 risk variants and the need for testing as part of the standard living donor evaluation process. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.02.007DOI Listing

Treating chronic hepatitis delta: The need for surrogate markers of treatment efficacy.

J Hepatol 2019 May 27;70(5):1008-1015. Epub 2018 Dec 27.

Department of Gastroenterology and Hepatology, Essen University Hospital, University of Duisburg-Essen, Essen, Germany.

Chronic hepatitis delta represents the most severe form of chronic viral hepatitis. The current treatment of hepatitis delta virus (HDV) infection consists of the use of interferons and is largely unsatisfactory. Several new compounds are currently in development for the treatment of HDV infection. Read More

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http://dx.doi.org/10.1016/j.jhep.2018.12.022DOI Listing

Renal transplantation for lupus nephritis: non-adherence and graft survival.

Lupus 2019 Apr 13:961203319842641. Epub 2019 Apr 13.

1 Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom.

Objectives: Poor adherence to immunosuppressive treatment is common in patients with systemic lupus erythematosus and may identify those with lupus nephritis (LN) who have a poorer prognosis. Non-adherence has also been reported to be a potential adverse outcome predictor in renal transplantation (rTp). We investigated whether non-adherence is associated with increased rTp graft rejection and/or failure in patients with LN. Read More

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http://journals.sagepub.com/doi/10.1177/0961203319842641
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http://dx.doi.org/10.1177/0961203319842641DOI Listing
April 2019
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En-Bloc Pediatric Kidney Transplant to Adult Recipient with Two Different Ureterovesical Anastomosis Techniques.

Am J Case Rep 2019 Apr 14;20:517-521. Epub 2019 Apr 14.

Department of Surgery and Internal Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Jeolla, South Korea.

BACKGROUND En-bloc kidney transplantation from a small pediatric donor to an adult recipient has become more common owing to the shortage of deceased donor kidneys. In pediatric en-bloc kidney transplantation, ureterovesical anastomosis can be done either via ureteroneocystostomy or via partial bladder wall transplantation. We report 2 cases of en bloc kidney transplantation from a pediatric deceased donor to an adult recipient using different ureterovesical anastomosis methods and the long-term outcomes. Read More

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http://dx.doi.org/10.12659/AJCR.914290DOI Listing

Management of Kidney Transplant Recipients by General Nephrologists: Core Curriculum 2019.

Am J Kidney Dis 2019 Apr 10. Epub 2019 Apr 10.

University of California, San Francisco, CA. Electronic address:

Kidney transplantation is associated with improvement in quality of life and mortality as compared to remaining on dialysis. It is therefore the optimal treatment for kidney failure for most patients. While transplantation nephrologists typically care for the patient in the first 6 months posttransplantation, general nephrologists and internists often care for kidney transplant recipients after this period. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02726386193016
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http://dx.doi.org/10.1053/j.ajkd.2019.01.031DOI Listing
April 2019
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[Remote monitoring of renal replacement treatments].

Authors:
Pierre Simon

Nephrol Ther 2019 Apr;15 Suppl 1:S65-S78

2, rue de Cherbourg, 22000 Saint-Brieuc, France. Electronic address:

Dialysis (haemodialysis, peritoneal dialysis) and renal transplantation are the renal replacement treatments when the personal kidneys have been destroyed. Renal grafting is the desired treatment for most patients who arrive at the terminal stage of their chronic kidney disease. Many patients with chronic kidney disease remain in chronic dialysis until the transplantation or their death. Read More

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http://dx.doi.org/10.1016/j.nephro.2019.03.009DOI Listing

The future of organ perfusion and re-conditioning.

Transpl Int 2019 Apr 13. Epub 2019 Apr 13.

Oxford Transplant Centre, Nuffield Department of Surgical Sciences, University of Oxford, Oxford University Hospitals, Churchill Hospital, Oxford, United Kingdom.

Organ preservation and re-conditioning using machine perfusion technologies continue to generate promising results in terms of viability assessment, organ utilisation and improved initial graft function. Here, we summarise the latest findings and study the results of ex-vivo/ex-situ hypothermic (HMP) and normothermic machine perfusion (NMP) in the area of abdominal organ transplantation (kidney, liver, pancreas and intestine). We also consider the potential role of normothermic regional perfusion (NRP) to re-condition DCD organs before retrieval. Read More

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http://dx.doi.org/10.1111/tri.13441DOI Listing

Proliferation rate and penicillin binding of enterococcal isolates from patients with immunosupression.

Lett Appl Microbiol 2019 Apr 13. Epub 2019 Apr 13.

Department of Pathology and Experimental Rheumatology, Medical University of Gdańsk, Gdańsk, Poland.

Low proliferation rate of bacterial populations was recently assumed to be a reason for higher resistance to antibiotics and appearance of many chronic infections. Slowly growing populations, called 'small colony variants' (SCVs) have been described in many bacterial species to make from as low as 0,02% up to 46% of population. Thirty enterococcal strains from urine and faeces of renal transplant recipients with asymptomatic, insignificant bacteriuria were studied. Read More

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http://dx.doi.org/10.1111/lam.13161DOI Listing

Beyond Death and Graft Survival - Variation in Outcomes after Kidney Transplant. Results from the NSQIP Transplant Beta Phase.

Am J Transplant 2019 Apr 12. Epub 2019 Apr 12.

Montefiore Einstein Center for Transplantation, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.

The National Surgical Quality Program (NSQIP) Transplant program was designed by transplant surgeons from the ground up to track post-transplant outcomes beyond basic recipient and graft survival. After an initial pilot phase, the program has expanded to 29 participating sites and enrolled more than 4300 recipient-donor pairs into the database, including 2876 complete kidney transplant cases. In this analysis, surgical site infection (SSI), urinary tract infection (UTI) and re-operation/intervention were evaluated for kidney transplant recipients. Read More

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http://dx.doi.org/10.1111/ajt.15391DOI Listing

Characterization of donor and recipient CD8+ tissue-resident memory T cells in transplant nephrectomies.

Sci Rep 2019 Apr 12;9(1):5984. Epub 2019 Apr 12.

Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Tissue-resident memory T (T) cells are characterized by their surface expression of CD69 and can be subdivided in CD103+ and CD103- T cells. The origin and functional characteristics of T cells in the renal allograft are largely unknown. To determine these features we studied T cells in transplant nephrectomies. Read More

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http://dx.doi.org/10.1038/s41598-019-42401-9DOI Listing

Vein "Beltization" Technique Facilitates Venous Anastomoses for Laparoscopic Orthotopic Kidney Transplantation in a Pig Model.

Transplant Proc 2019 Apr 9;51(3):913-918. Epub 2019 Jan 9.

Liver and Kidney Transplant Service, Sir Charles Gairdner Hospital, School of Surgery, The University of Western Australia, Nedlands, Perth, Australia.

Objective: This study was performed to investigate the safety and efficiency of the renal vein "beltization" technique for laparoscopic orthotopic kidney transplantation (LOKT) in a pig model.

Material And Methods: Kidney autotransplants were conducted, in which the renal vein beltization technique was employed, in 12 domestic pigs. In the operation, the right kidney was autotransplanted to the left kidney vessel trunks. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.034DOI Listing

Low-Dose-Rate and High-Dose-Rate Brachytherapy for Localized Prostate Cancer in ABO-Incompatible Renal Transplant Recipients.

Transplant Proc 2019 Apr 9;51(3):774-778. Epub 2019 Jan 9.

Division of Urology, Department of Regenerative & Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Background: Brachytherapy is one of the standard treatments for localized prostate cancer (CaP). However, the feasibility of brachytherapy for renal transplant recipients (RTRs) is still uncertain.

Materials And Methods: Between August 2007 and March 2018, all patients who had undergone low-dose-rate (LDR) brachytherapy or high-dose-rate (HDR) brachytherapy for clinically localized CaP at our institution were retrospectively identified (n = 394). Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.10.027DOI Listing

Pretransplant Homeostasis Model Assessment of Insulin Resistance and Fasting Plasma Glucose Predict New-Onset Diabetes After Renal Transplant in Chinese Patients.

Transplant Proc 2019 Apr 26;51(3):768-773. Epub 2019 Jan 26.

Department of Nephrology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address:

Background And Aim: The present study aims to determine if homeostasis model assessment of insulin resistance (HOMA-IR) index, fasting plasma glucose (FPG), and plasma insulin (Ins) are able to predict development of new onset diabetes after transplant (NODAT) for kidney recipients.

Methods: We performed a single-center retrospective study of 123 nondiabetic patients receiving a first renal transplant. The NODAT was diagnosed between 1 month and 1 year post transplant. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.062DOI Listing

Relationship Between Stress Coping Mechanisms and Depression in Kidney Transplant Recipients.

Transplant Proc 2019 Apr 9;51(3):761-767. Epub 2019 Jan 9.

Department of Transplantation Surgery, National Hospital Organization Mito Medical Center, Higashiibaraki, Ibaraki, Japan.

Background: It has been reported that transplant recipients are exposed to physical and psychosocial stresses even after transplant surgery and exhibit psychological disorders such as depression.

Purpose: In this study, we extracted trends concerning how recipients of kidney transplants cope with stress, and we also examined how they cope with depression and its countermeasures.

Method: We administered questionnaire surveys to 109 kidney transplant recipients. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.12.034DOI Listing
April 2019
4 Reads

Randomized, Open-Label, Phase IV, Korean Study of Kidney Transplant Patients Converting From Cyclosporine to Prolonged-Release Tacrolimus Plus Standard- or Reduced-Dose Corticosteroids.

Transplant Proc 2019 Apr 26;51(3):749-760. Epub 2019 Jan 26.

Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: This 24-week, multicenter, randomized, exploratory, comparative, open-label, phase-IV study assessed the safety and efficacy of prolonged-release tacrolimus (PR-T) with reduced-dose versus standard-dose corticosteroids in stable kidney transplant recipients in Korea after converting from cyclosporine-based therapy.

Methods: At baseline, patients were converted from cyclosporine-based to PR-T-based immunosuppression and randomized (1:1) to receive either corticosteroids maintained at prestudy dose (standard-dose group) or tapered from week 4 to 50% of the prestudy dose by week 12 (reduced-dose group). Patients were seen at baseline and weeks 1, 4, 12, and 24. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.057DOI Listing
April 2019
3 Reads

Self-management and Related Psychosocial Variables Among Renal Transplant Patients.

Transplant Proc 2019 Apr 9;51(3):734-741. Epub 2019 Jan 9.

Xiangya Nursing School, Central South University, Changsha, China. Electronic address:

Objective: To explore the influential factors of kidney transplant patients' self-management, especially psychosocial variables.

Study Design: This was a cross-sectional study.

Methods: Questionnaires were administered to patients with the assistance of our team members to gather sociodemographic information, medical characteristics, self-management, social support, depression, and flourishing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183122
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http://dx.doi.org/10.1016/j.transproceed.2019.01.033DOI Listing
April 2019
3 Reads

Investigator Assessment of the Utility of the TruGraf Molecular Diagnostic Test in Clinical Practice.

Transplant Proc 2019 Apr 11;51(3):729-733. Epub 2018 Dec 11.

Transplant Genomics Inc, Mansfield, MA.

Background: TruGraf v1 is a well-validated DNA microarray-based test that analyzes blood gene expression profiles as an indicator of immune status in kidney transplant recipients with stable renal function.

Methods: In this study, investigators assessed clinical utility of the TruGraf test in patient management. In a retrospective study, simultaneous blood tests and clinical assessments were performed in 192 patients at 7 transplant centers, and in a prospective observational study they were performed in 45 subjects at 5 transplant centers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183098
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http://dx.doi.org/10.1016/j.transproceed.2018.10.024DOI Listing
April 2019
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Application of TruGraf v1: A Novel Molecular Biomarker for Managing Kidney Transplant Recipients With Stable Renal Function.

Transplant Proc 2019 Apr 26;51(3):722-728. Epub 2019 Jan 26.

Transplant Genomics Inc, Mansfield, Massachusetts, United States; Comprehensive Transplant Center, Northwestern University, Chicago, Illionis, United States.

TruGraf v1 is a laboratory-developed DNA microarray-based gene expression blood test to enable proactive noninvasive serial assessment of kidney transplant recipients with stable renal function. It has been previously validated in patients identified as Transplant eXcellence (TX: stable serum creatinine, normal biopsy results, indicative of immune quiescence), and not-TX (renal dysfunction and/or rejection on biopsy results). TruGraf v1 is intended for use in subjects with stable renal function to measure the immune status as an alternative to invasive, expensive, and risky surveillance biopsies. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.054DOI Listing

Estimating the Net Utility Gains Among Donors and Recipients of Adult Living Donor Kidney Transplant.

Transplant Proc 2019 Apr 26;51(3):676-683. Epub 2019 Jan 26.

Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objectives: Living donor kidney transplant relieves the disease burden of patients with end-stage renal disease but may shorten donor life expectancy; however, their quality of life (QOL) is preserved. Nevertheless, the magnitude of the net gain of this procedure is unknown. We evaluated the QOL of both donors and recipients concurrently and calculated the net utility gain. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.049DOI Listing

Development of a Telehealth Intervention to Improve Access to Live Donor Kidney Transplantation.

Transplant Proc 2019 Apr 9;51(3):665-675. Epub 2019 Jan 9.

Division of General Internal Medicine, Department of Medicine, Duke University School of Medicine, Durham, NC, USA. Electronic address:

Background: Live donor kidney transplantation (LDKT) is underutilized by patients with end-stage kidney disease due to knowledge, communication, and logistical barriers.

Material And Methods: The Talking About Live Kidney Donation Social Worker Intervention (TALK-SWI) is a previously validated intervention demonstrated to improve patients' access to and pursuit of LDKT through in-person delivery of education and social support. To help overcome logistical barriers to LDKT, we adapted TALK-SWI into a telehealth intervention employing digital (ie, tablet, smartphone) and telephone technologies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183132
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http://dx.doi.org/10.1016/j.transproceed.2018.12.032DOI Listing
April 2019
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Determinants of Professional Activity After Kidney and Liver Transplantation: Questionnaire Development and Validation.

Transplant Proc 2019 Apr 6;51(3):651-664. Epub 2018 Dec 6.

Department of Clinical Nursing, Medical University of Warsaw, Warsaw, Poland. Electronic address:

Background: Organ transplantation is currently the treatment of choice in end-stage organ failure. Organ replacement therapy compensates for most of organ function loss and offers recipients the potential for an independent life; nevertheless, the employment rate after kidney or liver transplant is low vs the general population. The purpose of this study was to create a questionnaire for kidney and liver transplant patients that comprehensively assesses factors affecting employment among these people including demographic, physical, and psychosocial variables. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183162
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http://dx.doi.org/10.1016/j.transproceed.2018.12.001DOI Listing
April 2019
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Mapping French Laypeople's Views Regarding Living Organ Donation.

Transplant Proc 2019 Apr 9;51(3):613-618. Epub 2019 Jan 9.

Institute of Advanced Studies (EPHE), Paris, France.

Background: French laypeople's views on living organ donation (LOD) were examined.

Methods: From 2010 to 2014, 327 adults (including 21 nurses) judged the acceptability of LOD in 60 realistic scenarios composed of all combinations of 5 factors: 1. type of organ; 2. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.12.029DOI Listing
April 2019
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Factors affecting mortality during the waiting time for kidney transplantation: A nationwide population-based cohort study using the Korean Network for Organ Sharing (KONOS) database.

PLoS One 2019 12;14(4):e0212748. Epub 2019 Apr 12.

Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea.

Background: Long waiting time for deceased donor kidney transplant is inevitable due to the scarcity of donor, resulting in highlighting the importance of waiting time care. We analyzed the Korean Network for Organ Sharing (KONOS) database to assess the impact of waiting time on post-transplant survival outcomes and investigate risk factors for mortality by waiting time based on a complete enumeration survey in Korea.

Methods: We analyzed all persons aged over 18 years in deceased donor kidney transplant cases enrolled in the Korean Network for Organ Sharing (KONOS) database from January 2000 to January 2015. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212748PLOS