39,779 results match your criteria Renal Transplantation Medical


Emerging biomarkers of delayed graft function in kidney transplantation.

Transplant Rev (Orlando) 2021 May 26;35(4):100629. Epub 2021 May 26.

Nephrology, Dialysis and Transplantation Unit, Advanced Research Center on Kidney Aging (A.R.K.A.), Department of Medical and Surgical Sciences, University of Foggia, Italy. Electronic address:

Delayed Graft Function (DGF) is one of the most common early complications in kidney transplantation, associated with poor graft outcomes, prolonged post-operative hospitalization and higher rejection rates. Given the severe shortage of high-quality organs for transplantation, DGF incidence is expected to raise in the next years because of the use of nonstandard kidneys from Extended Criteria Donors (ECD) and from Donors after Circulatory Death (DCD). Alongside conventional methods for the evaluation of renal allograft [e. Read More

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Barriers to and Facilitators of Sustained Employment: A Qualitative Study of Experiences in Dutch Patients With CKD.

Am J Kidney Dis 2021 Jun 9. Epub 2021 Jun 9.

Department of Health Sciences, Applied Health Research, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Rationale & Objective: Although patients with chronic kidney disease (CKD) are at risk for work disability and work loss, not all experience work disruption. We aimed to describe the experienced barriers to and facilitators of sustained employment among Dutch patients with CKD.

Study Design: Qualitative study using semi-structured interviews. Read More

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A DL-4- and TNFα-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors.

Cell Mol Immunol 2021 Jun 11. Epub 2021 Jun 11.

Université de Paris, Imagine Institute, Laboratory of Human Lymphohematopoiesis, INSERM UMR 1163, Paris, France.

Several obstacles to the production, expansion and genetic modification of immunotherapeutic T cells in vitro have restricted the widespread use of T-cell immunotherapy. In the context of HSCT, delayed naïve T-cell recovery contributes to poor outcomes. A novel approach to overcome the major limitations of both T-cell immunotherapy and HSCT would be to transplant human T-lymphoid progenitors (HTLPs), allowing reconstitution of a fully functional naïve T-cell pool in the patient thymus. Read More

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Kidney transplant recipient perspectives on telehealth during the COVID-19 pandemic.

Transpl Int 2021 Jun 11. Epub 2021 Jun 11.

Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.

Background: The COVID-19 pandemic has challenged the delivery of health services. Telehealth allows delivery of care without in-person contacts and minimizes the risk of vial transmission. We aimed to describe the perspectives of kidney transplant recipients on the benefits, challenges and risks of telehealth. Read More

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T Cell Exhaustion in Organ Transplantation.

Transplantation 2021 Jun 9. Epub 2021 Jun 9.

Division of Nephrology, Dialysis, Transplantation, Giannina Gaslini Children's Hospital, Genoa, Italy UO Nefrologia, Azienda Ospedaliera-Universitaria di Parma, Parma, Italy Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts Division of Nephrology, Massachusetts General Hospital, Harvard Medical School Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

Exhaustion of T cells occurs in response to chronic exposure to self and foreign antigens. It limits T cell capacity to proliferate and produce cytokines, leading to an impaired ability to clear chronic infections or eradicate tumors. T cell exhaustion is associated with a specific transcriptional, epigenetic, and metabolic program and characteristic cell surface markers' expression. Read More

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TRough vs. AUC Monitoring of cyclosporine: A randomized comparison of adverse drug reactions in adult allogeneic stem cell recipients (TRAM study).

Eur J Haematol 2021 Jun 11. Epub 2021 Jun 11.

Clinical pharmacist/ clinical pharmacologist, Amsterdam University Medical Centers, department of Clinical Pharmacology and Pharmacy, Amsterdam, The Netherlands.

Objective: To investigate the incidence and severity of adverse drug reactions of cyclosporine using AUC targeted Therapeutic Drug Monitoring (TDM) compared to trough levels (C ) targeted TDM in adult allogeneic stem cell recipients.

Methods: Blind, monocentre, intervention study. Subjects were 1:1 randomized into either an AUC group or a C group. Read More

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CIRBP promotes ferroptosis by interacting with ELAVL1 and activating ferritinophagy during renal ischaemia-reperfusion injury.

J Cell Mol Med 2021 Jun 10. Epub 2021 Jun 10.

Department of Organ Transplantation, Shanghai Changhai Hospital, Shanghai, China.

Renal ischaemia-reperfusion (IR) is a major cause of acute kidney injury (AKI). Cold-inducible RNA-binding protein (CIRBP) may contribute to AKI because its deficiency protects against renal IR injury in a mechanism believed to involve ferroptosis. We aimed to investigate whether ferroptosis is associated with CIRBP-mediated renal damage. Read More

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Cumulative Deficits Frailty Index Predicts Outcomes for Solid Organ Transplant Candidates.

Transplant Direct 2021 Mar 22;7(3):e677. Epub 2021 Feb 22.

Ajmera Transplant Centre, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

Despite comprehensive multidisciplinary candidacy assessments to determine appropriateness for solid organ transplantation, limitations persist in identifying candidates at risk of adverse outcomes. Frailty measures may help inform candidacy evaluation. Our main objective was to create a solid organ transplant frailty index (FI), using the cumulative deficits model, from data routinely collected during candidacy assessments. Read More

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Deep Learning-Based Quantification of Visceral Fat Volumes Predicts Posttransplant Diabetes Mellitus in Kidney Transplant Recipients.

Front Med (Lausanne) 2021 25;8:632097. Epub 2021 May 25.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.

Because obesity is associated with the risk of posttransplant diabetes mellitus (PTDM), the precise estimation of visceral fat mass before transplantation may be helpful. Herein, we addressed whether a deep-learning based volumetric fat quantification on pretransplant computed tomographic images predicted the risk of PTDM more precisely than body mass index (BMI). We retrospectively included a total of 718 nondiabetic kidney recipients who underwent pretransplant abdominal computed tomography. Read More

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Characteristics and outcomes of patients with COVID-19 supported by extracorporeal membrane oxygenation: A retrospective multicenter study.

J Thorac Cardiovasc Surg 2021 May 18. Epub 2021 May 18.

Department of Cardiothoracic and Vascular Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.

Objective: To determine characteristics, outcomes, and clinical factors associated with death in patients with COVID-19 requiring extracorporeal membrane oxygenation (ECMO) support.

Methods: A multicenter, retrospective cohort study was conducted. The cohort consisted of adult patients (18 years of age and older) requiring ECMO in the period from March 1, 2020, to September 30, 2020. Read More

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Extracorporeal treatment for poisoning to beta-adrenergic antagonists: systematic review and recommendations from the EXTRIP workgroup.

Crit Care 2021 06 10;25(1):201. Epub 2021 Jun 10.

Research Center, CIUSSS du Nord-de-L'île-de-Montréal, Hôpital du Sacré-Coeur de Montréal, University of Montreal, Montreal, QC, Canada.

Background: β-adrenergic antagonists (BAAs) are used to treat cardiovascular disease such as ischemic heart disease, congestive heart failure, dysrhythmias, and hypertension. Poisoning from BAAs can lead to severe morbidity and mortality. We aimed to determine the utility of extracorporeal treatments (ECTRs) in BAAs poisoning. Read More

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The utility of cytolytic flow cytometry crossmatch before kidney transplantation.

Transpl Immunol 2021 Jun 7;68:101426. Epub 2021 Jun 7.

Department of Medical Immunology, Medical University of Gdańsk, Poland.

The donor/recipient matching in kidney transplantation is based on approved laboratory tests, which are complement-dependent cytotoxic crossmatch (CDC-XM) and flow cytometry crossmatch (FCXM). Both have some disadvantages: CDC-XM has low sensitivity, whereas FCXM does not differentiate between lytic vs. non-lytic alloantibodies. Read More

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Replacing centrifugation with mixing in urine analysis enriches protein pool in the urine samples.

Anal Biochem 2021 Jun 7;628:114284. Epub 2021 Jun 7.

Department of General and Transplantation Surgery, Medical University of Warsaw, Warsaw, Poland.

Urine is the basic diagnostic material, easy to collect, not requiring invasive approach. During standard procedure the urine samples are centrifuged and the supernatant analysed physically, biochemically, and microscopically. The centrifugation step removes proteins including those forming aggregates especially in the state of illness and after transplantation. Read More

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The prevalence and evidence-based management of needle fear in adults with chronic disease: A scoping review.

PLoS One 2021 10;16(6):e0253048. Epub 2021 Jun 10.

Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Background: Little is known about the prevalence and best management of needle fear in adults with chronic disease, who may experience frequent and long-term exposure to needles for lifesaving therapies such as renal dialysis and cancer treatment. Identifying interventions that assist in management of needle fear and associated distress is essential to support these patients with repeated needle and cannula exposure.

Method: We followed the PRISMA methodology for scoping reviews and systematically searched PsychINFO, PubMed (MEDLINE), ProQuest, Embase and grey literature and reference lists between 1989 and October 2020 for articles related to needle discomfort, distress, anxiety, fear or phobia. Read More

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The Role of Regulatory B cells in Kidney Diseases.

Front Immunol 2021 24;12:683926. Epub 2021 May 24.

Department of Kidney Transplantation, The Second Xiangya Hospital of Central South University, Changsha, China.

B cells, commonly regarded as proinflammatory antibody-producing cells, are detrimental to individuals with autoimmune diseases. However, in recent years, several studies have shown that regulatory B (Breg) cells, an immunosuppressive subset of B cells, may exert protective effects against autoimmune diseases by secretion of inhibitory cytokines such as IL-10. In practice, Breg cells are identified by their production of immune-regulatory cytokines, such as IL-10, TGF-β, and IL-35, however, no specific marker or Breg cell-specific transcription factor has been identified. Read More

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Factors and Outcomes of Intensive Care Unit Readmission in Elderly Patients.

Gerontology 2021 Jun 9:1-9. Epub 2021 Jun 9.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Republic of Korea.

Introduction: An increase in age has been observed among patients admitted to the intensive care unit (ICU). Age is a well-known risk factor for ICU readmission and mortality. However, clinical characteristics and risk factors of ICU readmission of elderly patients (≥65 years) have not been studied. Read More

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An intracapsular nephrectomy for the acquired cystic disease-associated renal cell carcinoma in renal transplant allograft: A clinical case report.

Medicine (Baltimore) 2021 May;100(19):e25858

Department of Urology.

Rationale: Acquired cystic disease-associated renal cell carcinoma (ACKD-RCC) is a unique subtype of renal cell carcinoma (RCC) and is found exclusively in patients with end-stage renal disease. We report a case of intracapsular nephrectomy (ICAN) of renal allograft with ACKD-RCC. To our knowledge, this is the first case in Asia of ICAN of renal allograft to treat ACKD-RCC. Read More

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Febrile neutropenia after kidney transplantation.

Am J Transplant 2021 Jun 9. Epub 2021 Jun 9.

Department of Medicine, Division of Nephrology, Columbia University Irving Medical Center, New York, USA.

Neutropenia is common after kidney transplant. There are few data on febrile neutropenia episodes (FNE) after kidney transplant. We studied FNE in a single-center retrospective cohort of 1,682 kidney transplant recipients. Read More

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Peer Mentoring as an Avenue to Explore in Kidney Transplantation: Kidney Transplant Recipients' Perspectives on Peer Mentoring.

Transplant Direct 2021 Mar 18;7(3):e672. Epub 2021 Feb 18.

Université de Montréal, Montréal, QC, Canada.

Kidney transplant recipients (KTRs) face numerous challenges following transplantation. Given that healthcare professionals do not necessarily have first-hand experience living with or waiting for a transplant, it may be hard for them to communicate with and help patients when it comes to transplant-related issues. KTRs have experiential knowledge, which could enable them to help other patients going through similar situations. Read More

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Providers' View on the First Kidney Transplantation Center in Ethiopia: Experience From Past to Present.

Health Serv Res Manag Epidemiol 2021 Jan-Dec;8:23333928211018335. Epub 2021 May 25.

University of Toronto, Toronto, Ontario, Canada.

Introduction: Transplantation is the optimal management for patients with end-stage renal disease. In Ethiopia, the first national kidney transplantation center was opened at St. Paul's Hospital Millennium Medical College in September 2015. Read More

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Egyptian clinical practice guideline for kidney transplantation.

Arab J Urol 2021 Jan 3;19(2):105-122. Epub 2021 Jan 3.

Nephrology Department, Kasr El-Einy Medical School, Cairo University, Cairo, Egypt.

: To present the first Egyptian clinical practice guideline for kidney transplantation (KT). : A panel of multidisciplinary subspecialties related to KT prepared this document. The sources of information included updates of six international guidelines, and review of several relevant international and Egyptian publications. Read More

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January 2021

In Search of a Better Outcome: Opting Into the Live Donor Paired Kidney Exchange Program.

Can J Kidney Health Dis 2021 26;8:20543581211017412. Epub 2021 May 26.

Department of Medicine, Dalhousie University, Halifax, NS, Canada.

Background: Live donor (LD) kidney transplantation is the best option for patients with end-stage kidney disease (ESKD). However, this may not be the best option if a patient's donor is older and considerably smaller in weight. Patient (A) with a less than ideal donor (Donor A) might enter into a live donor paired exchange (LDPE) program with the hopes of swapping for a better-quality organ. Read More

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A rare case report of gemcitabine-induced thrombotic microangiopathies.

SAGE Open Med Case Rep 2021 24;9:2050313X211013208. Epub 2021 May 24.

Division of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Department of Internal Medicine, Hannover Medical School, Hannover, Germany.

A 65-year-old female patient with breast cancer and soft tissue sarcoma who experienced a gemcitabine-induced thrombotic microangiopathies manifestation visited the emergency department. The renal biopsy revealed endothelial cell swelling, focal reduplication of glomerular basement membrane, and narrowed capillary lumens with fibrin deposition and fragmented erythrocytes which are compatible with thrombotic microangiopathies. The patient was presented with organ injury, acute renal failure with the need for hemodialysis technique. Read More

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Healthcare students support opt-out organ donation for practical and moral reasons.

J Med Ethics 2021 Jun 8. Epub 2021 Jun 8.

Department of Medicine, Division of Nephrology, Columbia University Irving Medical Center, New York, NY, USA

Background And Purpose: Changes to deceased organ donation policy in the USA, including opt-out and priority systems, have been proposed to increase registration and donation rates. To study attitudes towards such policies, we surveyed healthcare students to assess support for opt-out and priority systems and reasons for support or opposition.

Methods: We investigated associations with supporting opt-out, including organ donation knowledge, altruism, trust in the healthcare system, prioritising autonomy and participants' evaluation of the moral severity of incorrectly assuming consent in opt-in systems ('opt-in error') or opt-out systems ('opt-out error'), by conducting an online survey among healthcare students at a large academic institution. Read More

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Chronic kidney disease ten years after pediatric allogeneic hematopoietic stem cell transplantation.

Kidney Int 2021 Jun 5. Epub 2021 Jun 5.

Willem-Alexander Children's Hospital,Department of Pediatrics,Leiden University Medical Center,Leiden,The Netherlands.

Chronic kidney disease (CKD) is an important sequela of hematopoietic stem cell transplantation (HSCT), but data regarding CKD after pediatric HSCT are limited. In this single center cohort study, we evaluated the estimated glomerular filtration rate (eGFR) dynamics, proteinuria and hypertension in the first decade after HSCT and assessed risk factors for CKD in 216 pediatric HSCT survivors, transplanted 2002-2012. The eGFR decreased from a median of 148 to 116 ml/min/1. Read More

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Characterization of ABH-subtype donor-specific antibodies in ABO-A-incompatible kidney transplantation.

Am J Transplant 2021 Jun 8. Epub 2021 Jun 8.

Department of Nephrology, University Hospital, Birmingham, United Kingdom.

ABO-incompatible (ABOi) transplantation requires preemptive antibody reduction, however, the relationship between antibody-mediated rejection (AMR) and ABO-antibodies, quantified by haemagglutination (HA), is inconsistent, possibly reflecting variable graft resistance to AMR or HA assay limitations. Using an ABH-glycan microarray, we quantified ABO-A antigen-subtype (A-subtype)-specific IgM and IgG in 53 ABO-O recipients of ABO-A kidneys, before and after antibody removal (plasma exchange (TPE) or ABO-A-trisaccharide immunoadsorption (IA)) and one-year post-transplant. IgM binding to all A-subtypes correlated highly (R2≥0. Read More

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Association between preoperative lipid profiles and new-onset diabetes after transplantation in Chinese kidney transplant recipients: A retrospective cohort study.

J Clin Lab Anal 2021 Jun 8:e23867. Epub 2021 Jun 8.

Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, P.R. China.

Background: This study investigated the association between the preoperative lipid profiles and new-onset diabetes after transplantation (NODAT) in Chinese kidney transplant recipients (KTRs).

Methods: In this study, of 1140 KTRs registered between January 1993 and March 2018 in Zhongshan Hospital, Fudan University, 449 were enrolled. Clinical data, obtained through a chart review of the patient records in the medical record system, were evaluated, and NODAT was diagnosed based on the American Diabetes Association guidelines. Read More

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Socioeconomic inequality: Accessibility and outcomes after renal transplantation in New Zealand.

ANZ J Surg 2021 Jun 7. Epub 2021 Jun 7.

Anatomy with Medical Imaging, FMHS, University of Auckland, Auckland, New Zealand.

Background: Socioeconomic deprivation (SED) is a risk factor for worse outcomes after renal transplantation (RTx). This study aimed to evaluate access to RTx in different SED strata of the New Zealand population. We also assessed patient survival, acute cellular allograft rejection (AR) and allograft loss. Read More

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Assessing risk factors of acute kidney injury and its influence on adverse outcomes after lung transplantation: methodology is important.

Ren Fail 2021 Dec;43(1):926-927

Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.

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December 2021