Transplantation 2021 Jun 9. Epub 2021 Jun 9.
Division of Nephrology, Dialysis, Transplantation, Giannina Gaslini Children's Hospital, Genoa, Italy UO Nefrologia, Azienda Ospedaliera-Universitaria di Parma, Parma, Italy Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts Division of Nephrology, Massachusetts General Hospital, Harvard Medical School Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Exhaustion of T cells occurs in response to chronic exposure to self and foreign antigens. It limits T cell capacity to proliferate and produce cytokines, leading to an impaired ability to clear chronic infections or eradicate tumors. T cell exhaustion is associated with a specific transcriptional, epigenetic, and metabolic program and characteristic cell surface markers' expression. Read More