36,612 results match your criteria Renal Transplantation Medical


A study on clinical outcomes of combination of terlipressin and albumin in Hepatorenal Syndrome.

Scand J Gastroenterol 2020 Jul 7:1-5. Epub 2020 Jul 7.

Department of GI surgery, Amrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.

Background: Hepatorenal Syndrome (HRS) is a reversible functional renal impairment that occurs in patients with advanced liver cirrhosis or those with fulminant hepatic failure.

Aim: To evaluate the effect of terlipressin and albumin combination in various clinical outcomes in Hepatorenal Syndrome patients It was a prospective study involving 50 patients with HRS. The effectiveness parameters of the treatments were: confirmed HRS reversal, Recurrence of HRS within 90 days of treatment and mortality rate up to 90 days. Read More

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http://dx.doi.org/10.1080/00365521.2020.1786851DOI Listing

ADAMTS13 and VWF activities guide individualized caplacizumab treatment in patients with aTTP.

Blood Adv 2020 Jul;4(13):3093-3101

Department of Nephrology and Hypertension, Medical School Hannover, Hannover, Germany.

Introduction of the nanobody caplacizumab was shown to be effective in the treatment of acquired thrombotic thrombocytopenic purpura (aTTP) in the acute setting. The official recommendations include plasma exchange (PEX), immunosuppression, and the use of caplacizumab for a minimum of 30 days after stopping daily PEX. This study was a retrospective, observational analysis of the use of caplacizumab in 60 patients from 29 medical centers in Germany. Read More

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http://dx.doi.org/10.1182/bloodadvances.2020001987DOI Listing

Real-world data confirm the effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura.

Blood Adv 2020 Jul;4(13):3085-3092

Department of Nephrology and Hypertension, Medical School Hannover, Hannover, Germany.

Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare but life-threatening condition. In 2018, the nanobody caplacizumab was approved for the treatment of adults experiencing an acute episode of aTTP, in conjunction with plasma exchange (PEX) and immunosuppression for a minimum of 30 days after stopping daily PEX. We performed a retrospective, observational analysis on the use of caplacizumab in 60 patients from 29 medical centers in Germany during acute disease management. Read More

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http://dx.doi.org/10.1182/bloodadvances.2020001973DOI Listing

Wound healing adverse events in kidney transplant recipients receiving everolimus with reduced calcineurin inhibitor exposure or current standard-of-care: Insights from the 24 month TRANSFORM study.

Expert Opin Drug Saf 2020 Jul 7. Epub 2020 Jul 7.

Department of Transplant Surgery and Nephrology, Nagoya Daini Red Cross Hospital , Nagoya-City, Aich, Japan.

Objectives: In TRANSFORM, kidney transplant recipients received either everolimus in combination with reduced-exposure calcineurin inhibitor (EVR+rCNI) at standard EVR pre-dose concentrations of 3-8 ng/mL or mycophenolic acid plus standard-exposure CNI (MPA+sCNI). The authors analyzed the incidence of wound healing adverse events (WHAEs) over the 2-year study period.

Methods: Patients were randomized to either EVR+rCNI or MPA+sCNI, both combined with induction therapy and steroids. Read More

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http://dx.doi.org/10.1080/14740338.2020.1792441DOI Listing

Clinical spectrum, prognosis and estimated prevalence of DNAJB11-kidney disease.

Kidney Int 2020 Mar 23. Epub 2020 Mar 23.

Department of Nephrology, Hemodialysis and Renal Transplantation, University Hospital, Brest, France; Univ Brest, F-29200 Brest, France; National Institute for Research in Health Science (INSERM) UMR 1078, "Genetics, Genomics and Biotechnologies," Brest, France. Electronic address:

Monoallelic mutations of DNAJB11 were recently described in seven pedigrees with atypical clinical presentations of autosomal dominant polycystic kidney disease. DNAJB11 encodes one of the main cofactors of the endoplasmic reticulum chaperon BiP, a heat-shock protein required for efficient protein folding and trafficking. Here we conducted an international collaborative study to better characterize the DNAJB11-associated phenotype. Read More

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http://dx.doi.org/10.1016/j.kint.2020.02.022DOI Listing

Delayed remnant kidney function recovery is less observed in living donors who receive an analgesic, intrathecal morphine block in laparoscopic nephrectomy for kidney transplantation: a propensity score-matched analysis.

BMC Anesthesiol 2020 Jul 6;20(1):165. Epub 2020 Jul 6.

Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.

Background: This study analyzed remnant kidney function recovery in living donors after laparoscopic nephrectomy to establish a risk stratification model for delayed recovery and further investigated clinically modifiable factors.

Patients And Methods: This retrospective study included 366 adult living donors who underwent elective donation surgery between January 2017 and November 2019 at our hospital. ITMB was included as an analgesic component in the living donor strategy for early postoperative pain relief from November 2018 to November 2019 (n = 116). Read More

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http://dx.doi.org/10.1186/s12871-020-01081-zDOI Listing

Risk Factors in and Long-Term Survival of Patients with Post-Transplantation Diabetes Mellitus: A Retrospective Cohort Study.

Int J Environ Res Public Health 2020 Jun 25;17(12). Epub 2020 Jun 25.

Department of Pharmacy, Chi Mei Medical Center, Tainan City 71004, Taiwan.

Post-transplant diabetes mellitus (PTDM) is associated with infection, cardiovascular morbidity, and mortality. A retrospective cohort study involving patients who underwent renal transplantation in a transplantation center in Taiwan from January 2000 to December 2018 was conducted to investigate the incidence and risk factors of PTDM and long-term patient and graft survival rates. High age (45-65 vs. Read More

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http://dx.doi.org/10.3390/ijerph17124581DOI Listing

Cardiorenal Syndrome in Renal Transplant Recipients: Prevalence, Clinical Presentation, Treatment, and Outcome.

Cardiorenal Med 2020 Jul 6:1-7. Epub 2020 Jul 6.

Department of Nephrology, Arterial Hypertension, Dialysis, and Transplantation, University Hospital Center Zagreb, Faculty of Medicine, University of Zagreb, Zagreb, Croatia.

Background: Data on the cardiorenal syndrome (CRS) in renal transplant recipients (RTR) are scarce. We investigated the prevalence, clinical presentation, treatment, and outcomes of patients with CRS in our renal transplant cohort.

Methods: Charts and medical records of adult RTR were investigated to identify patients with renal allograft dysfunction and heart failure (HF) with reduced (HFrEF) or preserved (HFpEF) ejection fraction. Read More

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http://dx.doi.org/10.1159/000507728DOI Listing

Effects of the dialysate calcium concentrations and mineral bone disease treatments on mortality in The French Renal Epidemiology and Information Network (REIN) registry.

PLoS One 2020 6;15(7):e0235135. Epub 2020 Jul 6.

CESP, Centre for Research in Epidemiology and Population Health, Univ Paris-Saclay, Univ Paris Sud, UVSQ, INSERM UMRS, Villejuif, France.

Background: In patients on hemodialysis (HD), the various chemical elements in the dialysate may influence survival rates. In particular, calcium modifies mineral and bone metabolism and the vascular calcification rate. We studied the influence of the dialysate calcium concentration and the treatments prescribed for mineral bone disease (MBD) on survival. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235135PLOS

[Conducting bilateral tonsillectomy in patients after kidney transplantation. Clinical observation].

Vestn Otorinolaringol 2020 ;85(3):83-87

Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia.

The experience of performing bilateral tonsillectomy under general anesthesia for two patients with a transplanted kidney receiving immunosuppressive therapy is presented. In both patients after surgery, pain and inflammatory changes in the postsurgery wound were minimal. However, in the postsurgery period, infection was observed in patients, this required the prescription of systemic antibacterial drugs. Read More

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http://dx.doi.org/10.17116/otorino20208503183DOI Listing
January 2020

A novel method for creatinine adjustment makes the revised Lund-Malmö GFR estimating equation applicable in children.

Scand J Clin Lab Invest 2020 Jul 6:1-8. Epub 2020 Jul 6.

Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.

The aim of this study was to establish creatinine growth curves separately for males and females that can be used to adjust childhood levels of serum creatinine to corresponding adult levels. Linear regression with fractional polynomials of age as independent variable was used to construct creatinine growth curves for a reference cohort (n = 83,157 samples from Belgium and Sweden, age 2-40 years). Adjusted creatinine obtained from the growth curves was used to improve accuracy of estimated glomerular filtration rate (eGFR) based on the Lund-Malmö revised (LMR) equation in children. Read More

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http://dx.doi.org/10.1080/00365513.2020.1774641DOI Listing

Diagnostic performance of kSORT, a blood-based mRNA assay for non-invasive detection of rejection after kidney transplantation: a retrospective multicenter cohort study.

Am J Transplant 2020 Jul 5. Epub 2020 Jul 5.

French National Institute of Health and Medical Research (Inserm) Unit 1111, Lyon, France.

The Kidney Solid Organ Response Test (kSORT) blood gene expression assay was developed to non-invasively detect acute rejection (AR) after kidney transplantation. Its performance in a setting with natural disease prevalence has not been evaluated. A retrospective, multicenter cohort study was conducted across all single kidney transplant recipients, transplanted between 2011 and 2015, with samples within the first year after transplantation available in existing biobanks. Read More

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http://dx.doi.org/10.1111/ajt.16179DOI Listing

Phase 3 Trial of Human Islet-after-Kidney Transplantation in Type 1 Diabetes.

Am J Transplant 2020 Jul 6. Epub 2020 Jul 6.

Department of Surgery, University of Texas Dell Medical School, Austin, Texas, USA.

Allogeneic islet transplantation offers a minimally invasive option for β-cell replacement in the treatment of type 1 diabetes (T1D). The CIT consortium trial of purified human pancreatic islets (PHPI) in patients with T1D after kidney transplantation (CIT06), a National Institutes of Health (NIH)-sponsored phase 3, prospective, open-label, single-arm pivotal trial of PHPI, was conducted in 24 patients with impaired awareness of hypoglycemia while receiving intensive insulin therapy (IIT). PHPI were manufactured using standardized processes. Read More

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http://dx.doi.org/10.1111/ajt.16174DOI Listing

Feeding patterns and outcomes of enterally tube fed paediatric kidney transplant recipients.

Pediatr Nephrol 2020 Jul 5. Epub 2020 Jul 5.

Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

Objective: Many children with chronic kidney disease (CKD) exhibiting symptoms of poor appetite, gastro-oesophageal reflux and vomiting are reliant on enteral tube feeds (ETF) to achieve adequate nutritional intake. Following a successful renal transplant (RT), some of these symptoms may resolve and ETF then discontinued. There are only a few studies reporting the time taken to transition from ETF to complete oral feeding after transplantation. Read More

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http://dx.doi.org/10.1007/s00467-020-04618-zDOI Listing

Surgical learning curve in kidney transplantation: A systematic review and meta-analysis.

Transplant Rev (Orlando) 2020 Jun 27:100564. Epub 2020 Jun 27.

Department of Surgery, Division of HPB & Transplant Surgery, Erasmus University Medical Center (Erasmus MC), Doctor Molenwaterplein 40, 3015GD Rotterdam, Netherlands. Electronic address:

Aim: To assess the impact of the learning curve of kidney transplantation on operative and postoperative complications.

Methods: A literature search was systematically conducted to evaluate the significance of the learning curve on complications in kidney transplantation. Meta-analyses of the effect of the learning curve on warm ischemic time, total operating time (TOT), vascular and urological complications, postoperative bleeding, lymphocele and infection. Read More

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http://dx.doi.org/10.1016/j.trre.2020.100564DOI Listing

Early subclinical tubulitis and interstitial inflammation in kidney transplantation have adverse clinical implications.

Kidney Int 2020 Apr 25. Epub 2020 Apr 25.

Division of Transplant Nephrology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

This prospective observational cohort study compared the impact of subclinical tubulitis with or without interstitial inflammation to interstitial inflammation alone and to no inflammation in early post kidney transplant biopsies. A study cohort of 415 patients (living and deceased donor recipients) was divided into three groups on the basis of their three-month biopsy: 149 patients with No Inflammation (NI), 83 patients with Isolated Interstitial Inflammation (IIF), and 183 patients with Tubulitis [(with or without interstitial inflammation) (TIF) but not meeting criteria for Banff IA]. TIF was further divided into 56 patients with tubulitis without interstitial inflammation (TIF0) and 127 patients with tubulitis alongside interstitial inflammation (TIF1). Read More

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http://dx.doi.org/10.1016/j.kint.2020.03.028DOI Listing

The relationship between Helicobacter pylori and chronic kidney disease: update 2020.

Minerva Gastroenterol Dietol 2020 Jul 3. Epub 2020 Jul 3.

Renal Transplantation Center "A. Vercellone", Division of Nephrology Dialysis and Transplantation, Department of Medical Sciences, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.

A number of studies has confirmed that the epidemiology of Helicobacter pylori (H. pylori) is changing worldwide, with a decrease especially in developed Countries. Nevertheless, since this Gram-negative bacterium infects almost 50% of the world's population, it remains a global problem. Read More

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http://dx.doi.org/10.23736/S1121-421X.20.02729-4DOI Listing

Hemostatic Changes of Acute Kidney Injury in Patients With Cirrhosis: What Do They Mean?

Authors:
Ton Lisman

Hepatology 2020 Jul 4. Epub 2020 Jul 4.

Surgical Research Laboratory and Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Historically, patients with liver disease were considered to have a bleeding tendency that was a consequence of changes in their hemostatic system. An important consequence of this concept is the ever-ongoing policy of prophylactic blood product transfusion prior to invasive procedures aimed to reduce bleeding risk. However, it is increasingly acknowledged that although bleeding in patients with liver diseases can be the consequence of a (temporal) hypocoagulable state, it is frequently unrelated to hemostatic failure and rather caused by portal hypertension (e. Read More

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http://dx.doi.org/10.1002/hep.31451DOI Listing

A Frailty Screening Tool for Patients undergoing Orthotopic Heart Transplant.

Ann Thorac Surg 2020 Jul 2. Epub 2020 Jul 2.

Division of Cardiac Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA. Electronic address:

Background: Although frailty has been previously shown to negatively influence post-operative outcomes, frailty measurements remain undefined and underutilized for patients undergoing orthotopic heart transplantation (OHT). This study aims to derive and validate an OHT frailty screening tool.

Methods: The UNOS database was queried for adults undergoing OHT between 2000 and 2018. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.05.072DOI Listing

Hand-Assisted Laparoscopic vs Hand-Assisted Retroperitoneoscopic Living-Donor Nephrectomy: A Retrospective, Single-Center, Propensity-Score Analysis of 840 Transplants Using 2 Techniques.

Transplant Proc 2020 Jul 1. Epub 2020 Jul 1.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Introduction: Living-donor kidney transplantation (LDKT) is the most realistic option for patients with end-stage kidney disease because of a severe shortage of deceased donors. Hand-assisted laparoscopic donor nephrectomy (HALDN) and hand-assisted retroperitoneoscopic donor nephrectomy (HARDN) have been undertaken at our institute. We compared these 2 surgical procedures with respect to donor outcome and the graft function of recipients. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.01.134DOI Listing

Eight Weeks Treatment With Glecaprevir/Pibrentasvir Is Safe and Efficacious in an Integrated Analysis of Treatment-Naïve Patients With Hepatitis C Virus Infection.

Clin Gastroenterol Hepatol 2020 Jul 1. Epub 2020 Jul 1.

Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, United Kingdom.

Background & Aims: The direct-acting antiviral combination glecaprevir/pibrentasvir has been approved by the Food and Drug Administration for 8 weeks treatment in treatment-naïve patients with hepatitis C virus (HCV) infection without cirrhosis or with compensated cirrhosis. We performed an integrated analysis of data from trials to evaluate the overall efficacy and safety of 8 weeks glecaprevir/pibrentasvir in treatment-naïve patients without cirrhosis or with compensated cirrhosis.

Methods: We pooled data from 8 phase 2 or phase 3 trials of treatment-naïve patients with HCV genotype 1‒6 infections, without cirrhosis or with compensated cirrhosis, who received 8-week glecaprevir/pibrentasvir. Read More

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http://dx.doi.org/10.1016/j.cgh.2020.06.044DOI Listing

Effect of pre-transplant sarcopenia on the estimation of standard liver volume in living-donor liver transplant candidates: risk factor for post-transplant small for size syndrome?

Transpl Int 2020 Jul 4. Epub 2020 Jul 4.

Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Aim: To investigate whether LT candidates with sarcopenia are at an increased risk of receiving an inappropriate standard liver volume (SLV) estimation by standard body weight(BW)-derived SLV formula.

Methods: Non-BW-SLV estimation formulas were tested in 262 LDLT donors, and compared to a standard BW-SLV formula. The anthropometric parameters used were the thoracic width (TW-SLV) and thoracoabdominal circumference (TAC-SLV). Read More

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http://dx.doi.org/10.1111/tri.13690DOI Listing

Skin Architecture, Kidney Transplantation, and Their Relationship to Basal and Squamous Cell Carcinomas.

Anticancer Res 2020 Jul;40(7):4017-4022

Department of Translational Medical Sciences, University of Campania "L. Vanvitelli", Naples, Italy

Background/aim: Squamous cell carcinoma (SCC) is highly prevalent in kidney transplant patients (KT). It is characterized by the presence of an inflammatory infiltrate. In this study, we examined the presence of similar infiltrates in intact skin, which could be regarded as a precancerous step. Read More

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http://dx.doi.org/10.21873/anticanres.14396DOI Listing

Outcomes of liver-kidney transplantation in patients with primary hyperoxaluria: an analysis of the scientific registry of transplant recipients database.

BMC Gastroenterol 2020 Jul 3;20(1):208. Epub 2020 Jul 3.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health Key Laboratory of Organ Transplantation, Zhejiang University, No.79 Qingchun Road, Hangzhou, 310003, Zhejiang Province, China.

Background: Primary hyperoxaluria (PH) is an inherited disease lacking of hepatic oxalic acid metabolic enzymes which could lead to irreverisible renal damage. Currently, liver-kidney transplantation is a curative but highly invasive therapy used to treat patients with PH. However, limited studies have focused on combined liver-kidney transplantation (CLKT) and sequential liver and kidney transplantation (SLKT) in patients with PH. Read More

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http://dx.doi.org/10.1186/s12876-020-01349-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333252PMC

Peptides in Blood, Urine and Dialysate: Towards Unravelling Renal Peptide Handling.

Proteomics Clin Appl 2020 Jul 3:e2000029. Epub 2020 Jul 3.

T. He, V. Jankowski, Institute for Molecular Cardiovascular Research (IMCAR), University of Aachen, Weinheim, Germany.

Purpose: We investigated the peptidomes of spent hemodialysate, urine, and plasma, to shed light on peptide handling in the kidney.

Experimental Design: We collected 15 plasma, 15 urine and 13 spent hemodialysate samples from age and sex-matched subjects with chronic kidney disease. Peptide identification and quantification were performed with capillary electrophoresis-coupled mass spectrometry. Read More

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http://dx.doi.org/10.1002/prca.202000029DOI Listing
July 2020
2.683 Impact Factor

Nasal Bridles for Securing Nasoenteric Feeding Tubes: A Review of Clinical Effectiveness and Potential Complications.

Cureus 2020 May 28;12(5):e8325. Epub 2020 May 28.

Transplant Hepatology, Cleveland Clinic Florida, Weston, USA.

Nasal bridle is a feeding tube retaining device that is now increasingly used worldwide. While common complications tend to be minor, it is important to remain vigilant for newer adverse events. We hereby delineate the case of an elderly female who required nasoenteric feeding tube following simultaneous liver-kidney transplantation. Read More

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http://dx.doi.org/10.7759/cureus.8325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325339PMC

Amphiregulin Aggravates Glomerulonephritis Recruitment and Activation of Myeloid Cells.

J Am Soc Nephrol 2020 Jul 2. Epub 2020 Jul 2.

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Background: Recent studies have identified the EGF receptor (EGFR) ligand amphiregulin (AREG) as an important mediator of inflammatory diseases. Both pro- and anti-inflammatory functions have been described, but the role of AREG in GN remains unknown.

Methods: The nephrotoxic nephritis model of GN was studied in AREG mice after bone marrow transplantation, and in mice with myeloid cell-specific EGFR deficiency. Read More

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http://dx.doi.org/10.1681/ASN.2019111215DOI Listing

Quality of care after AKI development in the hospital: Consensus from the 22nd Acute Disease Quality Initiative (ADQI) conference.

Eur J Intern Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Pharmacy; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, United States.

Background: Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Quality improvement has been identified as an important goal in the care of patients with AKI. Different settings can be targeted to improve AKI care, broadly classified these include the inpatient and outpatient environments. Read More

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http://dx.doi.org/10.1016/j.ejim.2020.04.056DOI Listing

Angiotensin II receptor 1 antibodies associate with post-transplant focal segmental glomerulosclerosis and proteinuria.

BMC Nephrol 2020 Jul 2;21(1):253. Epub 2020 Jul 2.

Department of Medicine, Division of Nephrology, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Carnegie 344B, Baltimore, MD, 21287, USA.

Background: Angiotensin II type 1 receptors (AT1Rs) are expressed on podocytes, endothelial and other cells, and play an essential role in the maintenance of podocyte function and vascular homeostasis. The presence of AT1R antibodies (AT1R-Abs) leads to activation of these receptors resulting in podocyte injury and endothelial cell dysfunction. We assessed the correlation between AT1R-Abs and the risk of post-transplant FSGS. Read More

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http://dx.doi.org/10.1186/s12882-020-01910-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331243PMC

The attitude of kidney transplant recipients towards elective arteriovenous fistula ligation.

PLoS One 2020 2;15(7):e0234931. Epub 2020 Jul 2.

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wrocław, Poland.

Background: Arteriovenous fistulas (AVF) are a source of various complications. Among previously hemodialyzed kidney transplant recipients (KTxR), the AVF may persist over time. The patients' decisions whether to ligate the functioning AVF may be prompted by many factors. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234931PLOS

Two rapid, accurate liquid chromatography tandem mass spectrometry methods for the quantification of seven uremic toxins: An application for describing their accumulation kinetic profile in a context of acute kidney injury.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Jun 13;1152:122234. Epub 2020 Jun 13.

EA 7517 MP3CV, UPJV, F-80054 Amiens, France; Laboratory of Pharmacology and Toxicology, Amiens-Picardie University Hospital, F-80054 Amiens, France. Electronic address:

Acute kidney injury (AKI) is a frequent, serious complication in critically ill patients. Even if renal replacement therapy is rapidly initiated, AKI may lead to the acute accumulation of metabolic waste products called uremic toxins (UTs). Although the accumulation and effects of UTs have been extensively described in the setting of chronic kidney disease (CKD), few data are available for AKI. Read More

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http://dx.doi.org/10.1016/j.jchromb.2020.122234DOI Listing

Tacrolimus trough levels higher than 6 ng/mL might not be required after a year in stable kidney transplant recipients.

PLoS One 2020 2;15(7):e0235418. Epub 2020 Jul 2.

Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.

Background: Little is known regarding optimal tacrolimus (TAC) trough levels after 1 year post-transplant in stable kidney transplant recipients (KTRs) who have not experienced renal or cardiovascular outcomes. This study aimed to investigate the effect of 1-year post-transplant TAC trough levels on long-term renal and cardiovascular outcomes and opportunistic infections in stable KTRs.

Methods: KTRs receiving TAC with mycophenolate-based immunosuppression who did not experience renal or cardiovascular outcomes within 1 year post-transplant were enrolled from a multicenter observational cohort study. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235418PLOS

Approach and Management of Hypertension After Kidney Transplantation.

Front Med (Lausanne) 2020 16;7:229. Epub 2020 Jun 16.

Department of Medicine, University of California Irvine School of Medicine, Orange, CA, United States.

Hypertension is one of the most common cardiovascular co-morbidities after successful kidney transplantation. It commonly occurs in patients with other metabolic diseases, such as diabetes mellitus, hyperlipidemia, and obesity. The pathogenesis of post-transplant hypertension is complex and is a result of the interplay between immunological and non-immunological factors. Read More

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http://dx.doi.org/10.3389/fmed.2020.00229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310511PMC

Long-term retrospective observation study to evaluate effects of adiponectin on skeletal muscle in renal transplant recipients.

Sci Rep 2020 Jul 1;10(1):10723. Epub 2020 Jul 1.

Department of Nephrology, Kanazawa Medical University School of Medicine, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293, Japan.

Although it has been reported that chronic kidney disease exacerbates sarcopenia progression, the mechanisms of the process remain unclear. Fifty-one patients who underwent renal transplantation at our hospital since 1998 (31 males and 20 females; aged 29-52 years at the time of transplantation) were retrospectively examined for the relationships among the psoas muscle index (PMI), intramuscular adipose tissue content (IMAC), serum adiponectin fractions (high-/low-molecular-weight) and new-onset diabetes after transplantation (NODAT). Before transplantation, age at kidney transplantation negatively correlated with PMI and positively correlated with IMAC (rS = - 0. Read More

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http://dx.doi.org/10.1038/s41598-020-67711-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330033PMC

Adverse Drug Reactions in Patients with CKD.

Clin J Am Soc Nephrol 2020 Jul 1. Epub 2020 Jul 1.

Department of Clinical Pharmacology, Amiens University Hospital, Amiens, France.

Background And Objectives: Little is known about the burden of adverse drug reactions in CKD. We estimated the incidence of overall and serious adverse drug reactions and assessed the probability of causation, preventability, and factors associated with adverse drug reactions in patients seen by nephrologists.

Design, Setting, Participants, & Measurements: The Chronic Kidney Disease-Renal Epidemiology and Information Network cohort included 3033 outpatients (65% men) with CKD and eGFR<60 ml/min per 1. Read More

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http://dx.doi.org/10.2215/CJN.01030120DOI Listing

Association of Pretransplant BK Polyomavirus Antibody Status with BK Polyomavirus Infection After Kidney Transplantation: A Prospective Cohort Pilot Study of 47 Transplant Recipients.

Transplant Proc 2020 Jun 28. Epub 2020 Jun 28.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Prevention and early detection of BK polyomavirus (BKV) infection is important for long-term kidney graft survival; hence, pretransplant screening methods are essential to identify recipients at high risk for BKV infection. This study investigated the association of pretransplant donor and recipient BKV antibody status with the occurrence of post-transplant BKV infection.

Methods: We prospectively enrolled 47 adult living donor kidney transplant pairs from December 2014 to January 2016. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.01.164DOI Listing

Plant-Dominant Low-Protein Diet for Conservative Management of Chronic Kidney Disease.

Nutrients 2020 06 29;12(7). Epub 2020 Jun 29.

Division of Nephrology, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.

Chronic kidney disease (CKD) affects >10% of the adult population. Each year, approximately 120,000 Americans develop end-stage kidney disease and initiate dialysis, which is costly and associated with functional impairments, worse health-related quality of life, and high early-mortality rates, exceeding 20% in the first year. Recent declarations by the World Kidney Day and the U. Read More

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http://dx.doi.org/10.3390/nu12071931DOI Listing
June 2020
3.148 Impact Factor

Neonatal and Maternal Outcomes among Women with Glomerulonephritis.

Am J Nephrol 2020 Jul 1:1-8. Epub 2020 Jul 1.

1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.

Background: The outcomes of pregnancy in women with renal diseases remain controversial. The purpose of the study was to report fetal and maternal outcomes among women with glomerular disease in comparison with healthy pregnant women and a review of the current literature on this issue.

Methods: Retrospective analysis included 72 pregnancies in 62 women with biopsy-proven glomerulonephritis (GN) (in 65. Read More

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http://dx.doi.org/10.1159/000508600DOI Listing

The usefulness of quantitative interferon-gamma releasing assay response for predicting active tuberculosis in kidney transplant recipients: a quasi-experimental study.

J Infect 2020 Jun 28. Epub 2020 Jun 28.

Surgery, and Nephrology, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Objectives: We evaluated the effectiveness of IGRA-based isoniazid (INH) treatment with the diagnostic value of quantitative IGRA titer for post-transplant tuberculosis (TB) in kidney transplant (KT) recipients.

Methods: All adult KT recipients were enrolled from January 2014 to December 2017. The development of TB after KT was observed, stratified by quantitative IGRA results as well as by IGRA results with/without INH treatment. Read More

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http://dx.doi.org/10.1016/j.jinf.2020.06.070DOI Listing

Impact of COVID-19 on liver transplantation in Europe: Alert from an early survey of European Liver and Intestine Transplantation Association (ELITA) and European Liver Transplant Registry (ELTR).

Transpl Int 2020 Jul 1. Epub 2020 Jul 1.

Medical Liver Transplant Unit and Liver Department, Henri Mondor Hospital AP-HP, Paris Est University, France.

There are scarce data on the impact of COVID-19 pandemic on liver transplantation (LT) in Europe. The aim of this study was to obtain a preliminary data on incidence, management and outcome of COVID-19 in liver transplant recipients and candidates in Europe. An internet-based survey was sent to the centers affiliated with ELTR. Read More

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http://dx.doi.org/10.1111/tri.13680DOI Listing

-acetylcysteine as a treatment for amatoxin poisoning: a systematic review.

Clin Toxicol (Phila) 2020 Jul 1:1-8. Epub 2020 Jul 1.

Department of Emergency Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.

Amatoxin leads to the majority of deaths by mushroom poisoning around the world. Amatoxin causes gastrointestinal disturbances and multiple organ dysfunction, including liver and renal failure. As a potential treatment for amatoxin poisoning, -acetylcysteine (NAC) has been used for decades but its benefit is still unproven. Read More

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http://dx.doi.org/10.1080/15563650.2020.1784428DOI Listing

T-cell adoptive immunotherapy for BK nephropathy in renal transplantation.

Transpl Infect Dis 2020 Jul 1:e13399. Epub 2020 Jul 1.

Kidney Health Service, Royal Brisbane and Women's Hospital, Butterfield Street, Herston 4029, Queensland, Australia.

Introduction: BK virus (BKPyV) nephropathy occurs in 1-10% of kidney transplant recipients, with suboptimal therapeutic options.

Case: A 54-year-old received a transplant in March 2017. BKPyV was detected at 1. Read More

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http://dx.doi.org/10.1111/tid.13399DOI Listing

Heart and kidney transplant: should they be combined or subsequent?

ESC Heart Fail 2020 Jun 30. Epub 2020 Jun 30.

Department of Medicine, University of Wisconsin Hospital and Clinics, Madison, WI, USA.

Aims: End-stage heart failure patients often present with severe kidney failure and have limited treatment options. We compared the clinical characteristics and outcomes among end-stage heart and kidney failure patients who underwent combined heart and kidney transplant (HKTx) with those who underwent kidney transplant after heart transplant (KAH).

Methods And Results: All patients from 2007-2016 who underwent combined HKTx (n = 715) and those who underwent KAH (n = 130) using the United Network for Organ Sharing database were included. Read More

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http://dx.doi.org/10.1002/ehf2.12864DOI Listing

Practical Considerations for Solid Organ Transplantation During the COVID-19 Global Outbreak: The Experience from Singapore.

Transplant Direct 2020 Jun 8;6(6):e554. Epub 2020 May 8.

Department of Infectious Diseases, Singapore General Hospital, Singapore.

The current coronavirus disease 2019 (COVID-19) pandemic has not only caused global social disruptions but has also put tremendous strain on healthcare systems worldwide. With all attention and significant effort diverted to containing and managing the COVID-19 outbreak (and understandably so), essential medical services such as transplant services are likely to be affected. Closure of transplant programs in an outbreak caused by a highly transmissible novel pathogen may be inevitable owing to patient safety. Read More

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http://dx.doi.org/10.1097/TXD.0000000000001002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266363PMC

Development and Validation of a Nomogram Predicting the Prognosis of Renal Cell Carcinoma After Nephrectomy.

Cancer Manag Res 2020 11;12:4461-4473. Epub 2020 Jun 11.

Department of Urology, The First Hospital of Shanxi Medical University, Taiyuan, People's Republic of China.

Objective: To develop and validate a nomogram for predicting the overall survival (OS) of renal cell carcinoma (RCC) patients after nephrectomy.

Materials And Methods: In total, 488 patients with RCC who underwent nephrectomy at the Urology Department of the First Hospital of Shanxi Medical University between January 2013 and December 2018 were randomly divided into a development cohort (n = 344) and a validation cohort (n = 144). The development cohort was used to build a prediction model, and the validation cohort was used for validation. Read More

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http://dx.doi.org/10.2147/CMAR.S250371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295215PMC

Synchronous Bilateral Carcinoma of the Ureters. Report of a Case and a Short Discussion of the Literature.

In Vivo 2020 Jul-Aug;34(4):2057-2060

Department of Anatomy and Surgical Anatomy, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Background/aim: The strategy for treatment of bilateral simultaneous renal pelvic and/or ureteral tumors has not been established and is dependent on individual decision.

Case Report: We herein report the case of an elderly man who was examined for fatigue at the emergency department and subsequently diagnosed with bilateral ureteral cancer. The most common histologic type of ureteral cancer is urothelial (transitional epithelium) cancer and though it is rare, it can be synchronously present in the contralateral ureter. Read More

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http://dx.doi.org/10.21873/invivo.12007DOI Listing

A Comparison of the BEAM and MITO/MEL Conditioning Regimens for Autologous Hematopoietic Stem Cell Transplantation in Hodgkin Lymphoma: An Analysis of Efficiency and Treatment-Related Toxicity.

Clin Lymphoma Myeloma Leuk 2020 May 21. Epub 2020 May 21.

Baskent University Adana Adult Bone Marrow Transplantation Center, Adana, Turkey.

Background: Approximately half of patients with relapsed chemosensitive disease achieve robust responses with BEAM (BCNU, etoposide, cytarabine, and melphalan) and autologous stem cell rescue. The scarcity of comparative studies further limits alternative treatment protocols, such as the MITO/MEL (mitoxantrone, melphalan) protocol.

Patients And Methods: In this retrospective multicenter study, we compared the BEAM and MITO/MEL regimens used before autologous hematopoietic stem cell transplantation (ASCT) in terms of efficacy and side effects in patients with Hodgkin lymphoma. Read More

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http://dx.doi.org/10.1016/j.clml.2020.05.009DOI Listing

Alopecia in Children Following Living Related Liver Transplantation: A Case Report.

Transplant Proc 2020 Jun 27. Epub 2020 Jun 27.

Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Introduction: Alopecia is a common complication in patients following kidney transplantation; however, reports regarding liver transplantation patients are still few.

Methods: This study followed 111 children who underwent living related liver transplantation. Alopecia patients and its possible risk factors were analyzed. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.05.020DOI Listing

High Incidence of Amoxicillin-Induced Crystal Nephropathy in Patients Receiving High Dose of Intravenous Amoxicillin.

J Clin Med 2020 Jun 27;9(7). Epub 2020 Jun 27.

Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, CHU Angers, 49000 Angers, France.

Background: Amoxicillin (AMX)-induced crystal nephropathy (AICN) is considered as a rare complication of high dose intravenous (IV) AMX administration. However, recently, its incidence seems to be increasing based on French pharmacovigilance centers. Occurrence of AICN has been observed mainly with IV administration of AMX and mostly under doses over 8 g/day. Read More

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http://dx.doi.org/10.3390/jcm9072022DOI Listing