32,658 results match your criteria Renal Transplantation Medical


Clonal expansion of hepatic progenitor cells and differentiation into hepatocyte-like cells.

Dev Growth Differ 2019 Feb 20. Epub 2019 Feb 20.

Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Hepatic progenitor cells (HPCs) in adult liver are promising for treatment of liver diseases. A biliary-derived HPC population in adult mice has been characterized by co-expression of stem cell marker Sry (sex determining region Y)-box 9 (SOX9) and biliary marker cytokeratin 7 (CK7). However, isolation of these HPCs in adult healthy liver without any selection procedures remains a big challenge in this field. Read More

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http://doi.wiley.com/10.1111/dgd.12596
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http://dx.doi.org/10.1111/dgd.12596DOI Listing
February 2019
1 Read

Cytomegalovirus and Epstein-Barr virus infections among pediatric kidney transplant recipients at a center using universal Valganciclovir Prophylaxis.

Pediatr Transplant 2019 Feb 20:e13382. Epub 2019 Feb 20.

Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.

Background: CMV is associated with adverse effects in renal transplant recipients. The objective of this study was to characterize the incidence and timing of CMV and EBV infections in relation to valGCV prophylaxis in a pediatric renal transplant cohort.

Methods: Retrospective cohort of pediatric renal transplant patients given universal valGCV prophylaxis and universal viral surveillance was evaluated. Read More

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http://dx.doi.org/10.1111/petr.13382DOI Listing
February 2019

Evaluation of hemostasis in patients with end-stage renal disease.

PLoS One 2019 20;14(2):e0212237. Epub 2019 Feb 20.

Department of General, Visceral and Transplant Surgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

An increased bleeding risk is reported for patients with end-stage renal disease. This study aims to analyze, whether bleeding risk can be assessed by global tests of hemostasis. Standard laboratory tests and an extended evaluation of hemostasis by rotational thromboelastometry, platelet function analyzer (PFA) and multiple electrode aggregometry as well as thrombin generation assays and measurement of fibrinolytic potential were performed in 20 patients on hemodialysis, 10 patients on peritoneal dialysis, 10 patients with chronic kidney disease stage G5 (CKD5) and in 10 healthy controls (HC). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212237PLOS
February 2019

Time dependent p53 inhibition determines senescence attenuation and long term outcome after renal ischemia/reperfusion.

Am J Physiol Renal Physiol 2019 Feb 20. Epub 2019 Feb 20.

Children's Hospital, Medical School Hannover, Germany.

Inhibition of p53 has been shown to be an efficient strategy for ameliorating kidney ischemia/reperfusion (I/R) injury in experimental models. The therapeutic value of p53 siRNA based inhibition for I/R in renal transplantation is currently evaluated in clinical studies. While the major rationale for these studies is the suppression of pro-apoptotic properties, there are more, equally important injury response pathways regulated by p53. Read More

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http://dx.doi.org/10.1152/ajprenal.00333.2018DOI Listing
February 2019

Novel ELISA for thrombospondin type 1 domain-containing 7A autoantibodies in membranous nephropathy.

Kidney Int 2019 Mar;95(3):666-679

Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275 Valbonne Sophia Antipolis, France. Electronic address:

Autoantibodies against phospholipase A2 receptor 1 (PLA2R1) and thrombospondin type 1 domain-containing 7A (THSD7A) are emerging as biomarkers to classify membranous nephropathy (MN) and to predict outcome or response to treatment. Anti-THSD7A autoantibodies are detected by Western blot and indirect immunofluorescence test (IIFT). Here, we developed a sensitive enzyme-linked immunosorbent assay (ELISA) optimized for quantitative detection of anti-THSD7A autoantibodies. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.024DOI Listing

Executive summary for the 2015 Annual Data Report of the China Kidney Disease Network (CK-NET).

Kidney Int 2019 Mar;95(3):501-505

Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China; Peking-Tsinghua Center for Life Sciences, Beijing, China.

Chronic kidney disease (CKD) has received increased attention as a leading public health problem worldwide. Globally surveillance systems for kidney disease are still lacking, especially in developing countries like China, which constitutes an obstacle to develop effective preventive strategies. China Kidney Disease Network (CK-NET) was initiated in 2014 and further developed in accordance with the national strategy of prompting Big Data application in China. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183081
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http://dx.doi.org/10.1016/j.kint.2018.11.011DOI Listing
March 2019
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Relation between invasive hemodynamics and measured glomerular filtration rate by Cr-EDTA clearance in advanced heart failure.

Scand J Clin Lab Invest 2019 Feb 20:1-8. Epub 2019 Feb 20.

a Department of Cardiology , Rigshopsitalet , Copenhagen , Denmark.

The interaction between hemodynamics and kidney function in heart failure (HF) is incompletely understood. We investigated the association between invasive hemodynamic parameters and measured glomerular filtration rate (mGFR) by plasma clearance of 51-chromium-labeled ethylenediamine tetra-acetic acid (Cr-EDTA) in patients with advanced HF and tested the hypothesis that patients with reduced mGFR have lower cardiac index (CI) and mean arterial pressure (MAP) as well as higher central venous pressure (CVP) and pulmonary capillary wedge pressure (PCWP). We retrospectively studied 242 patients (mean age 50 ± 13 years) referred for evaluation for heart transplantation or implantation of a left ventricular assist device with a left ventricular ejection fraction < 45% on optimal medical therapy, who underwent right heart catheterization (RHC) and measurement of Cr-EDTA clearance. Read More

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http://dx.doi.org/10.1080/00365513.2019.1576221DOI Listing
February 2019

Development and evaluation of dedicated low clearance transplant clinics for patients with failing kidney transplants.

J Ren Care 2019 Mar;45(1):51-58

University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.

Background: Recipients with failing kidney transplants (RFKTs) may receive sub-optimal care compared with patients with native kidney disease. The aim of this study is to compare the outcomes of RFKTs managed in a dedicated low clearance transplant clinic (LCTC) compared with those attending a general transplant clinic.

Methods: We undertook a retrospective analysis of patients with failing kidney transplants comparing two clinics-a LCTC versus a general transplant clinic. Read More

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http://dx.doi.org/10.1111/jorc.12268DOI Listing

Primary CNS Lymphoma in the Elderly: The Challenge.

Acta Haematol 2019 Feb 15;141(3):138-145. Epub 2019 Feb 15.

Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.

Primary central nervous system (CNS) lymphoma is an aggressive brain tumor sensitive to chemotherapy and radiotherapy. Its incidence has increased in the elderly, and they account for the majority of patients. The median survival of patients older than 70 years did not change over the last 40 years and remained in the range of 6-7 months. Read More

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http://dx.doi.org/10.1159/000495284DOI Listing
February 2019

The Role of Osteopontin as a Diagnostic and Prognostic Biomarker in Sepsis and Septic Shock.

Cells 2019 Feb 18;8(2). Epub 2019 Feb 18.

CAAD, IRCAD, Department of Health Sciences, Università degli Studi del Piemonte Orientale, Corso Trieste 15, 28100 Novara (NO), Piedmont, Italy.

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host-response to infections. Osteopontin (OPN) is an extracellular matrix protein involved in the inflammatory response. Our aim was to evaluate the diagnostic and prognostic performance in sepsis of a single OPN determination in the Emergency Department (ED). Read More

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http://dx.doi.org/10.3390/cells8020174DOI Listing
February 2019

The renoprotective effects of naringin and trimetazidine on renal ischemia/reperfusion injury in rats through inhibition of apoptosis and downregulation of micoRNA-10a.

Biomed Pharmacother 2019 Feb 16;112:108568. Epub 2019 Feb 16.

Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; The Persian Gulf Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Renal Ischemia-Reperfusion (IR) injury occurs due to circulatory shock and renal transplantation, leading to mortality and morbidity worldwide. The primary purpose of the current study was to evaluate the renoprotective effects of the naringin (NAR) and trimetazidine (TMZ) on IR injury, renal hemodynamics, antioxidant capacity, microRNA-10a, and expression of apoptosis factors. Forty rats were divided into five groups randomly: Sham, IR injury, (TMZ, 5 mg/kg), (NAR pretreatment, 100 mg/kg), and TMZ plus NAR. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.01.029DOI Listing
February 2019

Statin use among Veterans with dialysis-dependent chronic kidney disease.

Hemodial Int 2019 Feb 19. Epub 2019 Feb 19.

Center for Innovation in Complex Chronic Healthcare, Veterans Administration Hospital, Hines, Illinois, USA.

Introduction: The benefits of statin medications in patients receiving maintenance dialysis remains controversial and clinical trials overall have shown no benefit. Potential side effects of statin medications include myalgias, myopathy, and memory loss and risk of side effects associated with statin medications increase with higher statin doses. We examined statin use and statin dose among Veterans with dialysis dependent CKD. Read More

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http://dx.doi.org/10.1111/hdi.12730DOI Listing
February 2019

Sequential transplantation and implications for clinical management: OLT followed by HCT and consequent RT in a pediatric patient.

Pediatr Transplant 2019 Feb 18:e13370. Epub 2019 Feb 18.

Section of Hematology, Oncology and BMT, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.

We report a case of a pediatric patient who required three separate transplants: OLT at the age 5, HCT at age 13 (8 years post-OLT), and cadaveric RT at age 15 (10 years post-OLT). The child initially presented with fulminant liver failure without known cause, ultimately undergoing OLT from his mother. He then developed SAA, for which he required HCT. Read More

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http://dx.doi.org/10.1111/petr.13370DOI Listing
February 2019

Emergency Department Visits After Kidney, Liver, and Heart Transplantation in a Hospital of a University in Turkey: A Retrospective Study.

Exp Clin Transplant 2019 Jan;17(Suppl 1):264-269

From the Department of Public Health, Baskent University, Ankara, Turkey.

Objectives: In our country, there are few publications evaluating emergency department visits among kidney, liver, and heart transplant recipients. Here, we examined emergency department visits of transplant recipients after initial hospital discharge following organ transplant performed in a medical faculty hospital in Ankara, Turkey.

Materials And Methods: We retrospectively analyzed hospital records of 1144 transplant recipients (700 kidney, 332 liver, and 112 heart) who underwent living-donor and deceased-donor organ transplant procedures in a university hospital between 2007 and 2017 and were admitted to the emergency department during the same period. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P120DOI Listing
January 2019

Living Unrelated Kidney Transplantation: Does It Prevent Deceased-Donor Kidney Transplantation Growth?

Exp Clin Transplant 2019 Jan;17(Suppl 1):250-253

From the Department of Urology and Kidney Transplantation, Shahid Labbafinejad Hospital, Urology Nephrology Research Center, Shahid Beheshti Medical University, Tehran, Iran.

Objectives: It is usually assumed that an active livingdonor transplant program inhibits the growth of a deceased-donor kidney transplant program. In our 33-year experience, we found the contrary to be true.

Materials And Methods: From 1984 until 2017, we performed a total of 4966 kidney transplant procedures. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P110DOI Listing
January 2019

Predictable and Unusual Adverse Effects of Immunosuppression in Pediatric Liver Transplant Patients.

Exp Clin Transplant 2019 Jan;17(Suppl 1):230-233

From the Department of Pediatric Gastroenterology,Gazi University Faculty of Medicine, Ankara, Turkey.

Objectives: Our aim was to determine potentially adverse effects of immunosuppressive protocols after liver transplantation in children.

Materials And Methods: The medical records of 60 children who underwent liver transplant retrospectively analyzed. Corticosteroid, tacrolimus, and mycophenolate mofetil were the primary immunosuppressive agents used in our center. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P81DOI Listing
January 2019

Living-Donor Kidney Transplant-Associated Thrombotic Microangiopathy Successfully Treated With Thymoglobulin: A Case Report.

Exp Clin Transplant 2019 Jan;17(Suppl 1):175-177

From the Dr. Soliman Fakeeh Hospital, Jeddah, Saudi Arabia; and the Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.

Transplantation is the ultimate therapy for end-stage kidney disease. Early graft dysfunction is a devastating event to patients and carries risk of graft loss. Medical causes of early graft loss include graft rejection, drug toxicity, and thrombotic microangiopathy. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P51DOI Listing
January 2019

Kidney Transplant in Pediatric Patient With Heart Failure: Case Report.

Exp Clin Transplant 2019 Jan;17(Suppl 1):153-155

From the Department of Transplantation, Servicios de Salud Del Estado de Queretaro, Hospital General de Querétaro, Querétaro, México.

Chronic kidney disease is defined as irreversible and progressive damage of the kidney. Chronicity is defined by the presence of renal dysfunction for at least 3 months, and renal dysfunction is defined through combinations of investigation (abnormal radiologic findings, abnormal urine or abnormal biochemistry reflecting renal dysfunction) and/or documentation of glomerular filtration rate below 60 mL/min/1.73 m². Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P23DOI Listing
January 2019

Long-Term Outcome of Zero-Ischemia Partial Nephrectomy for the Treatment of Multifocal Renal Cell Carcinoma in Renal Transplant Allograft: A Case Report.

Exp Clin Transplant 2019 Jan;17(Suppl 1):145-147

From the Department of Urology and Kidney Transplantation, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Multifocal synchronous renal cell carcinoma in the functioning allograft is a rare disease; there is no consensus regarding its treatment, and few cases have been reported. In isolated masses, some authorities advocate graft nephrectomy, and some recommend partial nephrectomy. To our knowledge, we describe the first experience of nephron-sparing surgery in multifocal synchronous renal cell carcinoma in an allograft with its long-term outcome. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P13DOI Listing
January 2019

Posttransplant Care of Kidney Transplant Recipients and Their Donors in Nigeria.

Exp Clin Transplant 2019 Jan;17(Suppl 1):50-56

From the Department of Medicine, College of Medicine, University of Nigeria, Ituku-Ozalla, Enugu, Nigeria; and the Department of Medicine, Federal Teaching Hospital, Abakaliki, Nigeria.

Objectives: Kidney transplantation is not readily available in low-resource settings because of poor health structure, dearth of experts, and pervading poverty. Although many centers now offer kidney transplant, patients still travel outside Nigeria for this service for many reasons and many return home without a detailed medical report.

Materials And Methods: Medical records of individuals who underwent kidney transplant in Nigeria and elsewhere and who were presently receiving posttransplant care or had received such care from 2002 to 2018 at 4 Nigerian hospitals were retrospectively reviewed and analyzed. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.L44DOI Listing
January 2019

Anti-HLA Antibody: The Role of Epitopes in Organ Transplantation.

Authors:
Hassan Argani

Exp Clin Transplant 2019 Jan;17(Suppl 1):38-42

From the Transplantation Ward, Modarres Hospital, Shahidbeheshti University of Medical Sciences, Tehran, Iran.

Recent developments have been achieved for better matching in solid-organ transplantation by epitope matching. HLA matching remains a standard immunologic strategy to determine organ compatibility for recipients. Advancements in tissue typing have introduced HLA matching at the epitope level. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.L41DOI Listing
January 2019

African-Americans with End Stage Renal Disease in the Early Years of Kidney Transplantation.

J Natl Med Assoc 2019 Feb 15. Epub 2019 Feb 15.

Departments of Pediatrics, Medicine and Surgery, MacLean Center for Clinical Medical Ethics, University of Chicago, USA. Electronic address:

Introduction: The first successful kidney transplant in humans was performed in 1954. In the following 25 years, the biomedical, ethical, and social implications of kidney transplantation were widely discussed by both healthcare professionals and the public. Issues relating to race, however, were not commonly addressed, representing a "blind spot" regarding racial disparities in access and health outcomes. Read More

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http://dx.doi.org/10.1016/j.jnma.2019.01.005DOI Listing
February 2019

Challenges and opportunities for nephrology in Western Europe.

Kidney Int 2019 Feb 16. Epub 2019 Feb 16.

Oxford Kidney Unit and Transplant Centre, Churchill Hospital, Oxford, UK.

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http://dx.doi.org/10.1016/j.kint.2018.09.028DOI Listing
February 2019

Continuous-Flow LVADs in the Nordic Countries: Complications and Mortality and its Predictors.

Scand Cardiovasc J 2019 Feb 19:1-22. Epub 2019 Feb 19.

j Department of Medicine , Karolinska Institutet and Heart and Vascular Theme, Karolinska University Hospital , Stockholm , Sweden.

Objectives: The purpose of this study was to assess complications and mortality and its predictors, with continuous-flow left ventricular assist devices (CF-LVADs) in the Nordic Countries.

Design: This was a retrospective, international, multicenter cohort study.

Results: Between 1993 - 2013 442 surgically implanted long-term mechanical assist devices were used among 8 centers in the Nordic countries. Read More

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https://www.tandfonline.com/doi/full/10.1080/14017431.2019.1
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http://dx.doi.org/10.1080/14017431.2019.1583365DOI Listing
February 2019
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Metabolic profiling of a chronic kidney disease cohort reveals metabolic phenotype more likely to benefit from a probiotic.

Int J Probiotics Prebiotics 2017 21;12(1):43-54. Epub 2017 Aug 21.

NIH Eastern Regional Comprehensive Metabolomics Resource Core, RTI International, 3040 E Cornwallis Rd., Durham, NC 27709, USA.

Scope: Persistent reduction in Glomerular Filtration Rate (GFR) is a hallmark of Chronic Kidney Disease (CKD) and is associated with an elevation of Blood Urea Nitrogen (BUN). This metabolomics pilot study sought to identify metabolites that differentiated patients with CKD whose BUN decreased on a probiotic and possible mechanisms.

Methods And Results: Metabolomics was used to analyze baseline plasma samples previously diagnosed with CKD Stage III-IV. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377160PMC

T-VEC in advanced Melanoma - Complete response in a heart and kidney transplant patient: A case report.

Br J Dermatol 2019 Feb 18. Epub 2019 Feb 18.

Departments of 1Dermatology and 2Surgery, Medical University of Vienna, Vienna, Austria.

Talimogene laherparepvec (T-VEC) is a intralesional oncolytic virotherapy, licensed in the European Union (EU) for locoregional advanced melanoma of American Joint Committee on Cancer (AJCC) stages IIIB, IIIC and IVM1a. Organ transplant recipients (OTRs) are so far excluded from all clinical trials dealing with immunotherapies due to the risk of transplant rejection. A 58-year-old caucasian male with a history of a heart and kidney transplantation in 2014 was diagnosed with melanoma (Breslow thickness of 1. Read More

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http://dx.doi.org/10.1111/bjd.17783DOI Listing
February 2019

Correlation of Cytomegalovirus (CMV) Disease Severity and Mortality With CMV Viral Burden in CMV-Seropositive Donor and CMV-Seronegative Solid Organ Transplant Recipients.

Open Forum Infect Dis 2019 Feb 14;6(2):ofz003. Epub 2019 Jan 14.

Department of Medicine and the Division of Geographic Medicine and Infectious Disease, Tufts Medical Center, and Tufts University School of Medicine, Boston, Masschusetts.

Background: The rate of cytomegalovirus (CMV) viral load increase and peak viral loads are associated with CMV disease in kidney and liver transplant recipients, but relationships to disease severity or mortality have not been shown.

Methods: Using stored serial serum specimens from renal (n = 59) and liver (n = 35) transplant recipients (D+R-; CMV-seropositive donors, CMV-seronegative recipients) from 2 prospective, randomized, controlled, interventional prophylaxis trials of CMV immune globulin (CMVIG), CMV viral load was measured using the COBAS quantitative polymerase chain reaction assay and the World Health Organization CMV standard. Patients with severe CMV-associated disease were classified according to trial definitions. Read More

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https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofz00
Publisher Site
http://dx.doi.org/10.1093/ofid/ofz003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366655PMC
February 2019
1 Read

Treatment and long-term outcome in primary distal renal tubular acidosis.

Nephrol Dial Transplant 2019 Feb 18. Epub 2019 Feb 18.

Department of Paediatric Nephrology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.

Background: Primary distal renal tubular acidosis (dRTA) is a rare disorder, and we aimed to gather data on treatment and long-term outcome.

Methods: We contacted paediatric and adult nephrologists through European professional organizations. Responding clinicians entered demographic, biochemical, genetic and clinical data in an online form. Read More

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http://dx.doi.org/10.1093/ndt/gfy409DOI Listing
February 2019
1 Read
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Management of Urinary Retention in Patients with Benign Prostatic Obstruction: A Systematic Review and Meta-analysis.

Eur Urol 2019 Feb 14. Epub 2019 Feb 14.

Department of Urology, University General Hospital of Heraklion, University of Crete Medical School, Heraklion, Crete, Greece. Electronic address:

Context: Practice patterns for the management of urinary retention (UR) secondary to benign prostatic obstruction (BPO; UR/BPO) vary widely and remain unstandardized.

Objective: To review the evidence for managing patients with UR/BPO with pharmacological and nonpharmacological treatments included in the European Association of Urology guidelines on non-neurogenic male lower urinary tract symptoms.

Evidence Acquisition: Search was conducted up to April 22, 2018, using CENTRAL, MEDLINE, Embase, ClinicalTrials. Read More

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http://dx.doi.org/10.1016/j.eururo.2019.01.046DOI Listing
February 2019

Monogenic causes of chronic kidney disease in adults.

Kidney Int 2019 Feb 12. Epub 2019 Feb 12.

Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

Approximately 500 monogenic causes of chronic kidney disease (CKD) have been identified, mainly in pediatric populations. The frequency of monogenic causes among adults with CKD has been less extensively studied. To determine the likelihood of detecting monogenic causes of CKD in adults presenting to nephrology services in Ireland, we conducted whole exome sequencing (WES) in a multi-centre cohort of 114 families including 138 affected individuals with CKD. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.031DOI Listing
February 2019

Contribution of non-HLA incompatibility between donor and recipient to kidney allograft survival: genome-wide analysis in a prospective cohort.

Lancet 2019 Feb 14. Epub 2019 Feb 14.

Department of Nephrology, Medical University of Vienna, Vienna, Austria. Electronic address:

Background: The introduction of HLA matching of donors and recipients was a breakthrough in kidney transplantation. However, half of all transplanted kidneys still fail within 15 years after transplantation. Epidemiological data suggest a fundamental role of non-HLA alloimmunity. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32473-5DOI Listing
February 2019

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice.

Mol Metab 2019 Feb 5. Epub 2019 Feb 5.

Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden; Clinical Nutrition Unit, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy; Cardiology Department, Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address:

Objective: Nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of advanced chronic liver disease. The progression of NAFLD, including nonalcoholic steatohepatitis (NASH), has a strong genetic component, and the most robust contributor is the patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 encoding the 148M protein sequence variant. We hypothesized that suppressing the expression of the PNPLA3 148M mutant protein would exert a beneficial effect on the entire spectrum of NAFLD. Read More

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http://dx.doi.org/10.1016/j.molmet.2019.01.013DOI Listing
February 2019
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The detection of BKPyV genotypes II and IV after renal transplantation as a simple tool for risk assessment for PyVAN and transplant outcome already at early stages of BKPyV reactivation.

J Clin Virol 2019 Feb 10;113:14-19. Epub 2019 Feb 10.

Institute for Virology, University Hospital Essen, University of Duisburg-Essen Virchowstr. 179, 45147, Essen, Germany.

Background: After reactivation the BK-polyomavirus (BKPyV) associated nephropathy (PyVAN) is observed in 1-10% of renal transplant recipients, of which up to 80% undergo graft failure. BKPyV reactivation after renal transplantation was associated with donor-derived serotypes against which the recipient has no immunological protection. However, PyVAN risk assessment seroactivity testing is a time-consuming and cost intensive process. Read More

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http://dx.doi.org/10.1016/j.jcv.2019.02.002DOI Listing
February 2019
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Potential pathological role of pro-inflammatory cytokines (IL-6, TNF-α, and IL-17) in xenotransplantation.

Xenotransplantation 2019 Feb 16:e12502. Epub 2019 Feb 16.

Department of Nephrology, Shenzhen Longhua District Central Hospital, Guangdong Medical University Affiliated Longhua District Central Hospital, Shenzhen, China.

The major limitation of organ transplantation is the shortage of available organs from deceased human donors which leads to the deaths of thousands of patients each year. Xenotransplantation is considered to be an effective way to resolve the problem. Immune rejection and coagulation dysfunction are two major hurdles for the successful survival of pig xenografts in primate recipients. Read More

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http://dx.doi.org/10.1111/xen.12502DOI Listing
February 2019
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Increasing of the interferon-γ gene expression during polyomavirus BK infection in kidney transplant patients.

Microb Pathog 2019 Feb 13;129:187-194. Epub 2019 Feb 13.

Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Polyomavirus BK infection is a common complication and a major cause of morbidity after kidney transplantation. Surveillance of kidney transplant recipients was threatened by reactivation of polyomavirus BK infection can lead to polyomavirus BK-associated nephropathy (PVN). Antiviral immunoregulatory markers like Gamma interferon (IFN-γ) might also affect the polyomavirus BK pathogenesis for its role in antiviral host defense, graft rejection, and regulative of the adaptive immune responses. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.015DOI Listing
February 2019
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Donor organ intervention before kidney transplantation: Head-to-head comparison of therapeutic hypothermia, machine perfusion, and donor dopamine pretreatment. What is the evidence?

Am J Transplant 2018 Jul 31. Epub 2018 Jul 31.

Department of Immunology, University of Heidelberg, Germany.

Therapeutic hypothermia, hypothermic pulsatile machine perfusion (MP), and renal-dose dopamine administered to stable brain-dead donors have shown efficacy to reduce the dialysis requirement after kidney transplantation. In a head-to-head comparison of the three major randomized controlled trials in this field, we estimated the number-needed-to-treat for each method, evaluated costs and inquired into special features regarding long-term outcomes. The MP and hypothermia trials used any dialysis requirement during the first post-operative week, while the dopamine trial assessed >1 dialysis session as primary endpoint. Read More

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http://dx.doi.org/10.1111/ajt.15317DOI Listing
July 2018
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Simultaneous laparoscopic left lateral sectionectomy and nephrectomy in the same living donor: The first case report.

Am J Transplant 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, National Medical Research Center of Transplantology and Artificial Organs named after academician V.I. Shumakov, Moscow, Russian Federation.

With the presence of organ shortage, living donors remain important sources of grafts, especially for pediatric recipients. Laparoscopic nephrectomy has become the gold standard for living donors. Additionally, laparoscopic partial liver procurement in living donors has proven its safety and feasibility in the latest studies. Read More

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http://dx.doi.org/10.1111/ajt.15318DOI Listing
February 2019
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A systematic review for variables to be collected in a transplant database for improving risk prediction.

Transplantation 2019 Feb 6. Epub 2019 Feb 6.

Evidence-Based Practice Research Program, Mayo Clinic, MN, USA.

Background: This systematic review was commissioned to identify new variables associated with transplant outcomes that are not currently collected by the Organ Procurement and Transplantation Network (OPTN).

Methods: We identified 81 unique studies including 1,193,410 patients with median follow-up of 36 months posttransplant, reporting 108 unique risk factors.

Results: Most risk factors (104) were recipient-related; few (4) were donor-related. Read More

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http://dx.doi.org/10.1097/TP.0000000000002652DOI Listing
February 2019
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Robot-assisted pyeloplasty for ureteropelvic junction obstruction: experience from a tertiary referral centre.

Minerva Urol Nefrol 2019 Feb 14. Epub 2019 Feb 14.

Department of Urology, University of Florence, Careggi Hospital, Florence, Italy.

Background: The aim of the study was to describe the surgical outcomes of a series of consecutive patients treated with robot-assisted pyeloplasty (RAP) for ureteropelvic junction obstruction in a single tertiary referral centre.

Methods: We prospectively collected and retrospectively analysed data of 292 patients submitted to RAP performed from September 2011 to December 2016 by four experienced surgeons. The stenotic ureteropelvic junction was resected according to the Anderson-Hynes technique. Read More

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http://dx.doi.org/10.23736/S0393-2249.19.03328-9DOI Listing
February 2019
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Current activity of xenotransplantation in Japan.

Xenotransplantation 2019 Jan 15;26(1):e12487. Epub 2019 Feb 15.

Japanese Society for Xenotransplantation, Nagakute, Japan.

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http://dx.doi.org/10.1111/xen.12487DOI Listing
January 2019
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Unveiling the Role of DNA Methylation in Kidney Transplantation: Novel Perspectives toward Biomarker Identification.

Biomed Res Int 2019 15;2019:1602539. Epub 2019 Jan 15.

Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, Via S. Sofia, 87, 95123 Catania, Italy.

The burden of chronic kidney disease is dramatically rising, making it a major public health concern worldwide. Kidney transplantation is now the best treatment for patients with end-stage renal disease. Although kidney transplantation may improve survival and quality of life, its long-term results are hampered by immune- and/or non-immune-mediated complications. Read More

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http://dx.doi.org/10.1155/2019/1602539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350635PMC
January 2019
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Corin Is Downregulated in Renal Ischemia/Reperfusion Injury and Is Associated with Delayed Graft Function after Kidney Transplantation.

Dis Markers 2019 14;2019:9429323. Epub 2019 Jan 14.

Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Renal ischemia/reperfusion (IR) injury is one of the most important risk factors for the occurrence of delayed graft function (DGF) after kidney transplantation; however, its mechanism remains not fully understood. In the present study, we screened differentially expressed genes in a murine model of renal IR injury by using high-throughput assays. We identified as one of the most significantly downregulated genes among 2218 differentially expressed genes (≥2-fold, < 0. Read More

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http://dx.doi.org/10.1155/2019/9429323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350528PMC
January 2019
1 Read
2.174 Impact Factor

Long Term Survival of Patients Undergoing TIPS in Budd-Chiari Syndrome.

J Clin Exp Hepatol 2019 Jan-Feb;9(1):56-61. Epub 2018 Mar 1.

Consultant, Department of Vascular and Interventional Radiology, Tan Tock Seng Hospital, Singapore.

Background: There has been significant improvement in understanding the etiology and management of Budd-Chiari Syndrome (BCS). Patients with chronic or acute-on-chronic BCS need radiological interventions in the form of angioplasty, hepatic vein/inferior vena cava stenting or Transjugular Intrahepatic Portosystemic Shunt (TIPS). Data regarding the long term follow up of patients undergoing TIPS is limited. Read More

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http://dx.doi.org/10.1016/j.jceh.2018.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363956PMC
March 2018
3 Reads

Major Adverse Cardiovascular Events Following Simultaneous Pancreas and Kidney Transplantation in the United Kingdom.

Diabetes Care 2019 Feb 14. Epub 2019 Feb 14.

Department of Renal and Pancreatic Transplantation, Manchester University NHS Foundation Trust, Manchester, U.K.

Objective: People with type 1 diabetes and kidney failure have an increased risk for major adverse cardiovascular events (MACE). Simultaneous pancreas and kidney transplantation (SPKT) improves survival, but the long-term risk for MACE is uncertain.

Research Design And Methods: We assessed the frequency and risk factors for MACE (defined as fatal cardiovascular disease and nonfatal myocardial infarction or stroke) and related nonfatal MACE to allograft failure in SPKT recipients with type 1 diabetes who underwent transplantation between 2001 and 2015 in the U. Read More

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-211
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http://dx.doi.org/10.2337/dc18-2111DOI Listing
February 2019
3 Reads

Overall and Site-Specific Cancer Mortality in Patients on Dialysis and after Kidney Transplant.

J Am Soc Nephrol 2019 Feb 14. Epub 2019 Feb 14.

School of Public Health, University of Sydney, Sydney, Australia.

Patients with ESRD have a substantially increased cancer risk, but few studies have examined the patterns of cancer mortality along a patient's journey from dialysis to transplantation.

Methods: We identified all Australian patients on dialysis and patients with transplants from 1980 to 2014 from the Australia and New Zealand Dialysis and Transplant Registry. Using standardized mortality ratios (SMRs), we compared cancer mortality among patients on dialysis and patients with transplants versus the general population (overall and by age, sex, year, and site); we also performed a subgroup analysis excluding patients with preexisting cancers. Read More

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http://dx.doi.org/10.1681/ASN.2018090906DOI Listing
February 2019
2 Reads
9.343 Impact Factor

Recommendations for ultrasonographic assessment of renal arteries.

J Ultrason 2018 ;18(75):338-343

Department of General Surgery and Endocrinology, Medical University of Warsaw , Poland.

The present clinical practice recommendations are addressed to physicians of all specialties, who perform Doppler ultrasound examinations of the kidneys on a daily basis, and in particular to specialists in radiology and imaging diagnostics. The recommendations were based on the Ultrasonography Standards of the Polish Ultrasound Society and current scientific reports consistent with Evidence Based Medicine. The paper discusses patient preparation protocol, examinat ion technique with particular emphasis on patient's position allowing to obtain proper Doppler angle of insonation, as well as diagnostic limitations of the technique. Read More

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http://dx.doi.org/10.15557/JoU.2018.0049DOI Listing
January 2018
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18F-FDG PET/CT Demonstrates Renal Cell Cancer in a Transplant With Synchronous Intestinal Infection.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

From the Departments of Nuclear Medicine and PET/CT, and.

We present a case of a 22-year-old man with history of allogenic renal transplantation on immunosuppression, who underwent F-FDG-PET/CT to characterize a lesion in the transplanted kidney on ultrasonogram and contrast-enhanced computed tomography imaging. PET/CT revealed FDG avid lesion in the transplanted kidney and mural thickening involving the distal ileum, ileocecal junction, and ileocolic lymph nodes. Subsequent histopathological examination from the renal lesion revealed renal cell carcinoma in the transplanted kidney. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002482DOI Listing
February 2019
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Influence of renal function by transplant operation for living-related kidney donors in a short term.

Chin Med J (Engl) 2019 Feb 8. Epub 2019 Feb 8.

Department of Urology/Institute of Urology/Organ Transplantation Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

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http://dx.doi.org/10.1097/CM9.0000000000000080DOI Listing
February 2019
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Experience with antiviral agents for treatment of hepatitis C virus infection in hemodialysis patients on the kidney wait list.

Hemodial Int 2019 Feb 14. Epub 2019 Feb 14.

Department of Transplantation and General Surgery, Baskent University Faculty of Medicine, Adana, Turkey.

Introduction: Hepatitis C virus (HCV) infection is associated with increased mortality and morbidity in kidney transplant patients. The ability to establish a sustained viral response before renal transplant is important for these patients. Direct-acting antiviral agents can increase the sustained viral response in most patients with HCV infection. Read More

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http://dx.doi.org/10.1111/hdi.12719DOI Listing
February 2019
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Reduction of exposure to tacrolimus trough level variability is associated with better graft survival after kidney transplantation.

Eur J Clin Pharmacol 2019 Feb 14. Epub 2019 Feb 14.

Department of Nephrology and Hypertension, Rabin Medical Center, Beilinson campus, 39, Jabutinsky st., Petah Tikva, Israel.

Purpose: High tacrolimus trough drug level variability was found to be associated with reduced graft survival. The primary goal of this study was to find whether reduction of exposure to high tacrolimus trough level variability in patients in which previously had high variability was associated with better graft survival.

Methods: All tacrolimus drug level values in patients that underwent kidney transplantation at our center between 2006 and 2015 were collected. Read More

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http://dx.doi.org/10.1007/s00228-019-02643-yDOI Listing
February 2019
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