135,445 results match your criteria Renal Transplantation


Medication adherence in pediatric renal transplant patients: The role of family functioning and parent health locus of control.

Pediatr Transplant 2019 Jan 20:e13346. Epub 2019 Jan 20.

Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Children and adolescents with renal disease experience daily social, emotional, and medical challenges. Renal transplantation can help to improve quality of life but requires a lifelong regimen of immunosuppressant medication to maintain health. Adherence to a daily complex regimen can be difficult, particularly for adolescents who are beginning to develop autonomy from caregivers and are faced with a unique set of socio-emotional challenges. Read More

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http://dx.doi.org/10.1111/petr.13346DOI Listing
January 2019

Periodontal status and clinical outcomes in kidney transplant recipients: a systematic review.

Oral Dis 2019 Jan 20. Epub 2019 Jan 20.

Dentistry Graduate Program, Federal University of Maranhão, São Luís, Maranhão, Brazil.

Objective: The aim of this systematic review was to identify clinical outcomes following kidney transplantation associated with periodontal status.

Material And Methods: A systematic review was conducted and included cross-sectional, case control or cohort studies published until August 2018 from PubMed/Medline, Scopus, Science Direct and CENTRAL. The research was carried out using the following descriptors: "kidney transplantation", "chronic renal failure", "periodontal diseases", "periodontitis", "chronic periodontitis", "gingival hyperplasia", and "gingivitis". Read More

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http://dx.doi.org/10.1111/odi.13040DOI Listing
January 2019

[Clinical management of patients with hemophilia A in nephrology: Diagnostic and therapeutic challenges illustrated by the cases of 2 patients].

Nephrol Ther 2019 Jan 16. Epub 2019 Jan 16.

Centre de néphrologie et transplantation rénale, hôpital de la conception, 147, boulevard Baille, Assistance publique-Hôpitaux de Marseille, 13005 Marseille, France; Center for cardiovascular and nutrition research (C2VN), Inra 1260, Inserm 1263, Aix-Marseille Université, Campus Timone, 13005 Marseille, France. Electronic address:

Hemophilia A is an X-linked genetic hemorrhagic disorder characterized by a factor VIII deficiency. The availability of secured substitution products has led to a dramatic improvement of life expectancy in hemophiliac patients. Nowadays, adult hemophiliac patients may develop Chronic Kidney Disease (CKD) resulting from age-related comorbidities (hypertension, obesity, diabetes). Read More

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http://dx.doi.org/10.1016/j.nephro.2018.10.002DOI Listing
January 2019

Incidence, distribution and clinical relevance of microbial contamination of preservation solution in deceased kidney transplantation: a retrospective cohort study from China.

Clin Microbiol Infect 2019 Jan 16. Epub 2019 Jan 16.

Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Key Laboratory of Kidney Disease Prevention and Control Technology, Zhejiang Province, China; Institute of Nephrology, Zhejiang University, Hangzhou, China; The Third Grade Laboratory under the National State, Administration of Traditional Chinese Medicine, Hangzhou, China.

Objectives: To determine whether microbial contamination of preservation solution (PS) in kidney transplantation is associated with donor derived infections (DDIs).

Methods: We retrospectively analyzed data from 1077 deceased kidney transplant recipients of 560 donors. 1002 PS samples were collected for microbiological assessment to establish the incidence and distribution of contamination. Read More

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http://dx.doi.org/10.1016/j.cmi.2018.12.040DOI Listing
January 2019

Hepatitis E virus genotype 3 and capsid protein in the blood and urine of immunocompromised patients.

J Infect 2019 Jan 16. Epub 2019 Jan 16.

Inserm UMR1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France; Laboratory of Virology, CHU Purpan, Toulouse, France; Université Paul Sabatier, Toulouse, France. Electronic address:

Objectives: Hepatitis E virus genotype 3 (HEV3) is responsible for acute and chronic liver disease in solid organ transplant (SOT) recipients. HEV was recently found in the urine of some acutely and chronically genotype 4-infected patients.

Methods: We examined the urinary excretion of HEV3 by 24 consecutive SOT recipients at the acute phase of HEV hepatitis and characterized the excreted virus. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.01.004DOI Listing
January 2019
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Variables of importance in the Scientific Registry of Transplant Recipients database predictive of heart transplant waitlist mortality.

Am J Transplant 2019 Jan 19. Epub 2019 Jan 19.

Department of Public Health Sciences, Division of Biostatistics, University of Miami, Miami, FL, USA.

The pre-listing variables essential for creating an accurate heart transplant allocation score based on survival are unknown. To identify these we studied mortality of adults on the active heart transplant waiting list in the Scientific Registry of Transplant Recipients database from January 1, 2004-August 31, 2015. There were 33,069 candidates awaiting heart transplantation: 7,681 UNOS Status 1A, 13,027 Status 1B, and 12,361 Status 2. Read More

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http://dx.doi.org/10.1111/ajt.15265DOI Listing
January 2019

UK Registry Analysis of Donor Substance Misuse and Outcomes Following Pancreas Transplantation.

Clin Transplant 2019 Jan 19:e13481. Epub 2019 Jan 19.

NIHR Blood and Transplant Research Unit, Institute of Transplantation, Freeman Hospital, Newcastle upon Tyne.

Substance abuse is unfortunately common in organ donors. Often these organs are declined for transplant, not only because of concerns around blood borne virus transmission but also because of perceived poor outcomes. In kidney transplantation, previous studies have demonstrated donor smoking status significantly impacts transplant outcome, but intravenous drug use or alcohol dependence does not. Read More

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http://dx.doi.org/10.1111/ctr.13481DOI Listing
January 2019

The 2017 Banting Memorial Lecture The diabetic lower limb - a forty year journey: from clinical observation to clinical science.

Authors:
A J M Boulton

Diabet Med 2019 Jan 19. Epub 2019 Jan 19.

University of Manchester, Manchester, UK.

A series of clinical research projects conducted over the past 40 years, all of which were informed by clinical observation or discussions with people with diabetes and staff colleagues are described in this review. A study of necrobiosis lipoidica iabeticorum confirmed that this rare skin complication occurs predominantly in young women with Type 1 diabetes and other microvascular complications. Biopsies of necrobiotic lesions showed destruction of superficial nerve fibres by inflammatory tissue, which likely causes the sensory loss in lesions that is pathognomonic of the condition. Read More

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http://dx.doi.org/10.1111/dme.13901DOI Listing
January 2019

The PIRP project (Prevenzione Insufficienza Renale Progressiva): how to integrate hospital and community maintenance treatment for chronic kidney disease.

J Nephrol 2019 Jan 18. Epub 2019 Jan 18.

Nephrology and Dialysis Unit, Ospedale S. Maria della Scaletta, Imola, Italy.

Chronic kidney disease (CKD) represents a global health burden with great economic impact on healthcare and therefore it requires appropriate interventions by Health Care Systems. The PIRP (Prevenzione Insufficienza Renale Progressiva) project is endorsed and funded by the Emilia-Romagna Regional Health Board and involves all the Nephrology Units of the Emilia-Romagna Region (Italy). The project has a predominantly clinical purpose and is expected to bring about a continuous quality improvement in the treatment of patients with CKD. Read More

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http://dx.doi.org/10.1007/s40620-018-00570-2DOI Listing
January 2019

Obesity phenotype and patient-reported outcomes in moderate and severe chronic kidney disease: a cross-sectional study from the CKD-REIN cohort study.

Qual Life Res 2019 Jan 18. Epub 2019 Jan 18.

INSERM, CHU Nancy, Université de Lorraine, CIC-1433, Epidémiologie clinique, 54000, Nancy, France.

Purpose: To evaluate the association between obesity phenotypes and health-related quality of life (HRQoL) in non-dialysis-dependent CKD patients.

Methods: Data from the national CKD-REIN cohort which included 3033 patients with stage 3-4 CKD were used. Patients were divided into three groups: non-obese (NO) patients (BMI < 30 kg/m), metabolically healthy obese (MHO) (BMI ≥ 30 kg/m and ≤ 1 criterion NCEP/ATP III), and metabolically unhealthy obese (MUO) (BMI ≥ 30 kg/m and ≥ 2 criteria NCEP/ATP III). Read More

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http://dx.doi.org/10.1007/s11136-019-02110-2DOI Listing
January 2019

PreImplantation Trial of Histopathology In renal Allografts (PITHIA): a stepped-wedge cluster randomised controlled trial protocol.

BMJ Open 2019 Jan 17;9(1):e026166. Epub 2019 Jan 17.

Department of Surgery, University of Cambridge, Cambridge, UK.

Introduction: Most potential kidney transplant donors in the UK are aged over 60 years, yet increasing donor age is associated with poorer graft survival and function. Urgent preimplantation kidney biopsy can identify chronic injury, and may aid selection of better 'quality' kidneys from this group. However, the impact of biopsy on transplant numbers remains unproven. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026166DOI Listing
January 2019

ESC Working Group on Cellular Biology of the Heart: Tissue Engineering and Cell-Based Therapies for Cardiac Repair in Ischemic Heart Disease and Heart Failure.

Cardiovasc Res 2019 Jan 17. Epub 2019 Jan 17.

Department of Cardiology, Experimental Cardiology Laboratory, Regenerative Medicine Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Morbidity and mortality from ischemic heart disease (IHD) and heart failure (HF) remain significant in Europe and are increasing worldwide. Patients with IHD or HF might benefit from novel therapeutic strategies, such as cell-based therapies. We recently discussed the therapeutic potential of cell-based therapies and provided recommendations on how to improve the therapeutic translation of these novel strategies for effective cardiac regeneration and repair. Read More

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http://dx.doi.org/10.1093/cvr/cvz010DOI Listing
January 2019

Predicting outcomes of liver transplantation in patients with NASH: pre-transplant renal function is key.

Liver Transpl 2019 Jan 18. Epub 2019 Jan 18.

Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine - DIMED, University of Padova, Padova, Italy.

Patients with renal impairment prior to LT have an increased risk of end-stage renal disease and post-LT mortality[1]. Since the introduction of the Model for End-Stage Liver Disease, the number of recipients with renal impairment prior to LT has significantly increased. This was paralleled by a concomitant increase of simultaneous liver-kidney transplantation (SLKT)[2] and severe chronic kidney disease (CKD) after LT[3]. Read More

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http://dx.doi.org/10.1002/lt.25413DOI Listing
January 2019

Quantitative assessment of microperfusion by indocyanine green angiography in kidney transplantation resembles chronic morphological changes in kidney specimens.

Microcirculation 2019 Jan 17:e12529. Epub 2019 Jan 17.

Department of Surgery, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167, Mannheim, Germany.

Objective: Indocyanine green fluorescence angiography enables a quantitative real-time perfusion assessment in kidney transplantation. The results of intraoperative microperfusion of the kidney allograft were compared to the renal chronicity score in pre-transplantation kidney biopsy specimens. The intrarenal resistance index was calculated by duplex sonography as a method of reference. Read More

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http://dx.doi.org/10.1111/micc.12529DOI Listing
January 2019

Repeated cell transplantation and adjunct renal denervation in ischemic heart failure: exploring modalities for improving cell therapy efficacy.

Basic Res Cardiol 2019 Jan 17;114(2). Epub 2019 Jan 17.

Cardiovascular Center of Excellence, LSU Health Sciences Center, 533 Bolivar St., Suite 408, New Orleans, LA, 70112, USA.

Enthusiasm for cell therapy for myocardial injury has waned due to equivocal benefits in clinical trials. In an attempt to improve efficacy, we investigated repeated cell therapy and adjunct renal denervation (RDN) as strategies for augmenting cardioprotection with cardiosphere-derived cells (CDCs). We hypothesized that combining CDC post-conditioning with repeated CDC doses or delayed RDN therapy would result in superior function and remodeling. Read More

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http://dx.doi.org/10.1007/s00395-019-0718-1DOI Listing
January 2019

Low Titers of Antidonor ABO Antibodies After ABO-Incompatible Living Donor Liver Transplantation: A Long-Term Follow-Up Study.

Transplant Direct 2019 Jan 27;5(1):e420. Epub 2018 Dec 27.

Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, Japan.

Background: The ABO blood-type barrier in kidney and liver transplantation has been overcome by aggressive treatments such as B cell depletion using rituximab. However, the long-term effects of ABO-incompatible liver transplantation (ABO-I LTx) on immunological status have not previously been studied. Here, we assessed whether long-term immune hyporesponsiveness against ABO blood-group antigens was retained. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324916PMC
January 2019

Treatment With Grazoprevir/Elbasvir for Renal Transplant Recipients With Chronic Hepatitis C Virus Infection and Impaired Allograft Function.

Transplant Direct 2019 Jan 27;5(1):e419. Epub 2018 Dec 27.

Department of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany.

Background: Direct-acing antiviral agents are highly efficient treatment options for chronic hepatitis C virus (HCV) infection after renal allograft transplantation. Treatment options for patients with impaired graft function remain limited. Therefore, we assessed the effectiveness and safety of grazoprevir/elbasvir therapy for patients with chronic HCV infection and impaired renal allograft function. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324915PMC
January 2019

Immunomics of Renal Allograft Acute T Cell-Mediated Rejection Biopsies of Tacrolimus- and Belatacept-Treated Patients.

Transplant Direct 2019 Jan 20;5(1):e418. Epub 2018 Dec 20.

Department of Internal Medicine, Division of Nephrology and Transplantation, Rotterdam Transplant Group, Erasmus MC, Rotterdam, the Netherlands.

Background: Belatacept-based therapy in kidney transplant recipient has been shown to increase long-term renal allograft and patient survival compared with calcineurin inhibitor-based therapy, however, with an increased risk of acute T cell-mediated rejection (aTCMR). An improved understanding of costimulation blockade-resistant rejections could lead to a more personalized approach to belatacept therapy. Here, immunomic profiles of aTCMR biopsies of patients treated with either tacrolimus or belatacept were compared. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324913PMC
January 2019
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Early Versus Late Conversion From Immediate to Prolonged-Release Tacrolimus After Renal Transplantation: Clinical Effects and Treatment Costs.

Transplant Direct 2019 Jan 20;5(1):e417. Epub 2018 Dec 20.

Department of Nephrology, São João Hospital Center, EPE, Alameda Prof. Hernâni Monteiro, Porto, Portugal.

Introduction: Prolonged-release tacrolimus (PR-TAC) was associated with improved renal function after transplantation when compared to immediate-release tacrolimus (IR-TAC) although evidence is still scarce. This study aimed to compare clinical outcomes and treatment costs in patients who converted from IR-TAC to PR-TAC during the first year after renal transplantation (RT) (early converters [EC]) or after that period (late converters [LC]).

Methods: We performed a retrospective study including 79 patients (EC, 39; LC, 41) which were followed up over 60 months. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324909PMC
January 2019

Infectious Disease Transmission in Solid Organ Transplantation: Donor Evaluation, Recipient Risk, and Outcomes of Transmission.

Transplant Direct 2019 Jan 20;5(1):e416. Epub 2018 Dec 20.

Divisions of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL.

In 2016, the Transplantation Society of Australia and New Zealand, with the support of the Australian Government Organ and Tissue authority, commissioned a literature review on the topic of infectious disease transmission from deceased donors to recipients of solid organ transplants. The purpose of this review was to synthesize evidence on transmission risks, diagnostic test characteristics, and recipient management to inform best-practice clinical guidelines. The final review, presented as a special supplement in Transplantation Direct, collates case reports of transmission events and other peer-reviewed literature, and summarizes current (as of June 2017) international guidelines on donor screening and recipient management. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324914PMC
January 2019

Nonimmunologic Donor-Recipient Pairing, HLA Matching, and Graft Loss in Deceased Donor Kidney Transplantation.

Transplant Direct 2019 Jan 19;5(1):e414. Epub 2018 Dec 19.

Nova Scotia Health Authority Division of Nephrology, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.

Background: In kidney transplantation, nonimmunologic donor-recipient (D-R) pairing is generally not given the same consideration as immunologic matching. The aim of this study was to determine how nonimmunologic D-R pairing relates to independent donor and recipient factors, and to immunologic HLA match for predicting graft loss.

Methods: Seven D-R pairings (race, sex, age, weight, height, cytomegalovirus serostatus, and HLA match) were assessed for their association with the composite outcome of death or kidney graft loss using a Cox regression-based forward stepwise selection model. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324912PMC
January 2019

Association of Dialysis Duration With Outcomes After Kidney Transplantation in the Setting of Long Cold Ischemia Time.

Transplant Direct 2019 Jan 17;5(1):e413. Epub 2018 Dec 17.

Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, Buffalo, NY.

Background: There is no mechanism that matches hard-to-place kidneys with the most appropriate candidate. Thus, unwanted kidney offers are typically to recipients with long renal replacement time (vintage) which is a strong risk factor for mortality and graft failure, and in combination with prolonged cold ischemia time (CIT), may promote interactive effects on outcomes.

Methods: Consecutive adult isolated kidney transplants between October 2015 and December 2017 were stratified by vintage younger than 1 year and CIT longer than 30 hours. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324908PMC
January 2019

Kidney Discard Rates in the United States During American Transplant Congress Meetings.

Transplant Direct 2019 Jan 4;5(1):e412. Epub 2018 Dec 4.

Department of Internal Medicine, Division of Nephrology and Hypertension, University of Utah School of Medicine, Salt Lake City, UT.

Background: Deceased-donor kidney discard rates vary by region, but it is unknown whether discard rates and transplant outcomes vary during the American Transplant Congress (ATC) each year.

Methods: Using national registry data, we determined rates of kidney discard, delayed graft function, graft failure, and mortality from December 31, 1999, through December 30, 2015, during ATC dates and compared these rates with those on the same days of the week during the 2 weeks before and after the ATC (non-ATC). We used multivariable regression to determine associations between ATC and these outcomes. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324911PMC
January 2019

Magnusiomyces clavatus infection in a child after allogeneic hematotopoetic stem cell transplantation: Diagnostic and therapeutic implications.

Med Mycol Case Rep 2019 Mar 21;23:65-67. Epub 2018 Dec 21.

Infectious Disease Unit, IRCCS Istituto Giannina Gaslini, Via Gaslini 5, 16147 Genova, Italy.

is an ascomycetous fungus causing invasive disease in immuno-compromised patients. Neutropenia, contaminated venous catheters, previous antifungal treatment are risk factors for this infection. We report a case of fungemia with pulmonary, renal and skin localizations in a 6-year-old boy with prolonged neutropenia because of three allogeneic hematopoietic stem cell transplantations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22117539183010
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http://dx.doi.org/10.1016/j.mmcr.2018.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329693PMC
March 2019
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An uncommon cause of loss of vision in a dialysis patient with lupus.

Clin Case Rep 2019 Jan 12;7(1):244-245. Epub 2018 Dec 12.

Division of Nephrology, Hypertension and Renal Transplantation University of Florida Gainesville Florida.

Optic neuropathy is an uncommon finding in dialysis patients and has been associated with uremia, ischemia (arteritic and nonarteritic), drugs (isoniazid, ethambutol), infections (tuberculosis), and intracranial hypertension. Inflammatory optic neuritis associated with lupus is relatively rare, but clinicians need to be aware of this condition and obtain urgent ophthalmology consultation. Read More

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http://dx.doi.org/10.1002/ccr3.1954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332756PMC
January 2019

Point-of-care renal ultrasound: Interpret with care.

Clin Case Rep 2019 Jan 22;7(1):233-235. Epub 2018 Nov 22.

Division of Nephrology, Hypertension and Renal Transplantation University of Florida Gainesville Florida.

Renal vascular malformations may mimic hydronephrosis on gray-scale ultrasound and can be easily differentiated using color doppler imaging. Non-radiology physicians performing point-of-care renal ultrasound should be aware of this finding to avoid mismanagement. Read More

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http://dx.doi.org/10.1002/ccr3.1934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333064PMC
January 2019

Noninvasive evaluation of renal tissue oxygenation with blood oxygen level-dependent magnetic resonance imaging early after transplantation has a limited predictive value for the delayed graft function.

Pol J Radiol 2018 5;83:e389-e393. Epub 2018 Aug 5.

Department of General and Transplant Surgery, Nicolaus Copernicus University, Collegium Medicum, Bydgoszcz, Poland.

Purpose: The aim of this study was to evaluate the feasibility of renal oxygenation assessment using blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) in the early period after kidney transplantation and to estimate its prognostic value for delayed graft function.

Material And Methods: Examinations were performed in 50 subjects: 40 patients within a week after the kidney transplantation and 10 healthy controls, using T2*-weighted sequence. Measurements in transplant patients were correlated to basic laboratory parameters in the early period after transplantation and at follow-up. Read More

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http://dx.doi.org/10.5114/pjr.2018.78622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334089PMC

Efficacy and Safety of Delayed Prolonged-Release Tacrolimus Initiation in De Novo Hepatitis C Virus-Negative Orthotopic Liver Transplant Recipients: A Single-Center, Single-Arm, Prospective Study.

Ann Transplant 2019 Jan 18;24:36-44. Epub 2019 Jan 18.

Liver Transplant Unit, University Hospital of Bellvitge, Barcelona, Spain.

BACKGROUND Delaying initiation of tacrolimus after liver transplantation (LT) is a potential renal-sparing strategy. We assessed safety and efficacy of delayed initiation of prolonged-release tacrolimus (PR-T) in de novo LT. MATERIAL AND METHODS This was a single-center, single-arm, prospective, 12-month observational study of hepatitis C virus-negative orthotopic LT patients. Read More

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http://dx.doi.org/10.12659/AOT.912444DOI Listing
January 2019
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Whole-Exome Sequencing Enables a Precision Medicine Approach for Kidney Transplant Recipients.

J Am Soc Nephrol 2019 Jan 17. Epub 2019 Jan 17.

Division of Nephrology,

Background: Whole-exome sequencing (WES) finds a CKD-related mutation in approximately 20% of patients presenting with CKD before 25 years of age. Although provision of a molecular diagnosis could have important implications for clinical management, evidence is lacking on the diagnostic yield and clinical utility of WES for pediatric renal transplant recipients.

Methods: To determine the diagnostic yield of WES in pediatric kidney transplant recipients, we recruited 104 patients who had received a transplant at Boston Children's Hospital from 2007 through 2017, performed WES, and analyzed results for likely deleterious variants in approximately 400 genes known to cause CKD. Read More

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http://dx.doi.org/10.1681/ASN.2018060575DOI Listing
January 2019
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Return to Work and Quality of Life: A Psychosocial Survey After Kidney Transplant.

Transplant Proc 2018 Jun 30. Epub 2018 Jun 30.

Vascular Surgery and Organ Transplant Unit, Department of Surgery, Transplantation and Advanced Technologies GF Ingrassia, University Hospital of Catania, Italy.

Background: The main goals of kidney transplantation are to recreate a condition of psychophysical well-being and to improve the quality of life of the patient, including going back to work after transplant. Returning to work after a kidney transplant is an important health care indicator. The aim of the study was to assess the psychophysical well-being and work condition in kidney transplant recipients and to identify possible predictors of return to work. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183086
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http://dx.doi.org/10.1016/j.transproceed.2018.04.083DOI Listing
June 2018
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Living Kidney Donation Is Recipient Age Sensitive and Has a High Rate of Donor Organ Disqualifications.

Transplant Proc 2018 Jun 30. Epub 2018 Jun 30.

Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.

Background: Living donor kidney transplantation (LDKT) is the best therapy for patients with chronic renal failure. Its advantages, compared with cadaveric transplantation, include the possibility of avoiding dialysis, the likelihood of best outcome, and donor pool expansion. Careful assessment of potential donors is important to minimize the risks and ensure success. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.03.136DOI Listing

Psychological and Emotional Aspects in Living Donor Kidney Transplantation.

Transplant Proc 2018 Jun 30. Epub 2018 Jun 30.

Vascular Surgery and Organ Transplant Unit, Department of Surgery, Transplantation, and Advanced Technologies GF Ingrassia, University Hospital of Catania, Italy; Department of Formative Science, University of Catania, Italy.

Background: The decision to resort to living donor transplantation determines a particular condition characterized by a strong mental and emotional anguish, both for the patients and their families. The purpose of the study was to correlate the relational dynamics between donor-recipient, donor/recipient couple with the health team, and the family support perceived by the couple with the quality of life 6 months before transplant and 12 months after transplant and compare the data between the 2 time points after participating in the psychotherapy program of counseling about behavioral change.

Patients And Methods: Twenty-seven donor and recipient pairs consented to participate. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183086
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http://dx.doi.org/10.1016/j.transproceed.2018.04.085DOI Listing
June 2018
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Our Timing to Remove Peritoneal Catheter Dialysis After Kidney Transplant.

Transplant Proc 2018 Jun 30. Epub 2018 Jun 30.

Operative Unit of General Surgery and Kidney Transplantation, Advanced Biomedical Science Department, University Federico II of Naples.

Background: Patients on peritoneal dialysis treatment represent 15% of the global dialysis population. The major complication of peritoneal dialysis is catheter and peritoneal infection. Peritoneal dialysis patients who receive kidney transplants are at increased risk of infection because of immunosuppressive therapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183085
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http://dx.doi.org/10.1016/j.transproceed.2018.04.075DOI Listing
June 2018
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Impact of 3 Major Maintenance Immunosuppressive Protocols on Long-term Clinical Outcomes: Result of a Large Multicenter Italian Cohort Study Including 5635 Renal Transplant Recipients.

Transplant Proc 2018 Jun 28. Epub 2018 Jun 28.

Renal Unit, Department of Medicine, University Hospital of Verona, Italy. Electronic address:

Background: Although optimization of immunosuppressive schemes in renal transplantation have minimized acute posttransplant complications, long-term outcomes are still not optimal and most of the chronic graft damage is drug-related. Therefore, to define the best long-term maintenance immunosuppressive regimen is of major importance in renal transplantation. To assess this objective, we undertook a large, multicenter cohort study in Italy. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.02.209DOI Listing

Risk Factors for Early Mortality in Liver Transplant Patients.

Transplant Proc 2018 Jun 28. Epub 2018 Jun 28.

Department of Medicine, UO Anesthesia and Intensive Care, Padua University, Padua, Italy. Electronic address:

Background: Liver transplantation (LT) is an established treatment for patients with end-stage liver disease. The significant advances in surgical technique, immunosuppression therapy, and anesthesiological management have dramatically improved short- and long-term outcomes. The aim of this study is to correlate specific surgical and anesthesiological variables with causes of early death in LT recipients. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.06.025DOI Listing

Liver Cirrhosis From Chronic Hypervitaminosis A Resulting in Liver Transplantation: A Case Report.

Transplant Proc 2019 Jan 14. Epub 2019 Jan 14.

Hepatobiliopancreatic Surgery and Liver Transplantation Unit, Department of General and Digestive Surgery, Virgen del Rocío University Hospital, Seville, Spain.

Herein we report a case of liver dysfunction caused by consumption of vitamin A supplements leading to liver transplantation. The patient was a 48-year-old male with a medical history of congenital ichthyosiform erythroderma in treatment with vitamin A until 12 years of age, at which point he discontinued the supplements because he had developed ascites. Liver cirrhosis was diagnosed as secondary to hypervitaminosis A on the basis of histologic examination of liver biopsy and the absence of other potential causes of chronic liver disease. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.03.141DOI Listing
January 2019

Use of Peritoneovenous Shunt for the Management of Refractory Ascites.

Transplant Proc 2018 Jun 30. Epub 2018 Jun 30.

Unit of Hepatobiliary Surgery and Liver Transplantation, CIBERehd, IMIBIC, University Hospital Reina Sofía, Córdoba, Spain.

Background: Guidelines for the management of refractory ascites (RA) recommend transjugular intrahepatic portosystemic shunting (TIPS), diuretics, and paracentesis as the main strategies, discouraging use of surgical peritoneovenous shunts (PVSs). However, PVSs, including both Denver (DS) or saphenoperitoneal (SPS) modalities, may still have indications. Herein we report our experience with PVSs in the context of modern surgical and anesthetic management. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183088
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http://dx.doi.org/10.1016/j.transproceed.2018.04.089DOI Listing
June 2018
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Donation After Cardiac Death in Liver Transplantation: An Additional Source of Organs With Similar Results to Donation After Brain Death.

Transplant Proc 2018 Jun 28. Epub 2018 Jun 28.

Department of Surgery, Obstetrics and Ginecology, Faculty of Medicine, Universidad de Málaga, Málaga, Spain; Hepatobiliopancreatic Surgery and Transplant Unit, General and Digestive Surgery Service, Hospital Regional Universitario de Málaga, Málaga, Spain.

Background: As new sources of organs are needed, liver transplantation using donors after cardiac death (DCD) is progressively increasing, but outcomes with this method are still being questioned. We performed this study to verify that DCD outcomes are comparable to those seen in donation after brain death (DBD).

Methods: This was a prospective cohort study including 100 liver transplantation performed between 2014 and 2017, divided according to donor type in 75 DBD and 25 DCD. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.02.208DOI Listing

Liver Transplant From Controlled Cardiac Death Donors Using Normothermic Regional Perfusion: Comparison With Liver Transplants From Brain Dead Donors.

Transplant Proc 2018 Jun 28. Epub 2018 Jun 28.

Department of General Surgery, University Hospital "Marqués de Valdecilla," Santander, Spain.

Background: Liver transplantation from donors after either controlled or uncontrolled cardiac death (DCD) is associated with considerable rates of primary nonfunction (PNF) and ischemic cholangiopathy (IC). Normothermic regional perfusion (NRP) could significantly reduce such rates.

Methods: Retrospective study to analyze short-term (mortality, PNF, vascular complications) and long-term (IC, survival) complications in 11 liver transplants from controlled DCDs using NRP with extracorporeal membrane oxygenation (ECMO) (group 1). Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.067DOI Listing
June 2018
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FTO rs9939609 Gene Polymorphism and Obesity: Lack of Association in Kidney Transplantation.

Transplant Proc 2018 Jun 30. Epub 2018 Jun 30.

Transplant Unit, S. Salvatore Hospital, L'Aquila, Italy; Department of Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy.

The fat mass and obesity-associated (FTO) gene is one of the most important obesity susceptibility genes. Some FTO gene polymorphisms have been associated with obesity, diabetes, and hypertension, all conditions for which, after transplant, there is increased susceptibility, due to effects of immunosuppressive regimens. To evaluate whether FTO could be a candidate for targeted preventive intervention in the transplant setting, we investigated whether the common genetic variation, FTO rs9939609T>A, could affect weight gain and risk of cardiovascular complications in kidney transplantation. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.080DOI Listing

Ethical Issues in the Use of Suboptimal Kidneys for Transplants: An Italian Point of View.

Transplant Proc 2018 Jun 30. Epub 2018 Jun 30.

Operative Unit of General Surgery and Kidney Transplantation, Advanced Biomedical Science Department, University Federico II of Naples, Naples, Italy.

The shortage of organs leads to the need for utilizing suboptimal kidneys for transplantation. The distinction between optimal, marginal, and suboptimal kidneys leads surgeons to face not only technical problems but also ethical and legal issues related to clinical advantages offered by the transplant of a nonstandard kidney and the acquisition of consent. Between 1999 and 2015, we performed 658 transplants, 49 (7. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.05.031DOI Listing

Switch From Twice-daily Tacrolimus to Once-daily, Prolonged-release Tacrolimus in Kidney Transplantation: Long-term Outcome.

Transplant Proc 2018 Jun 30. Epub 2018 Jun 30.

UOC Chirurgia dei Trapianti, Policlinico Tor Vergata-Tor Vergata University, Rome, Italy.

Background: One daily dose of tacrolimus (QDT) improves adherence in kidney transplant (KT) recipients. A switch from twice-daily tacrolimus (BDT) to QDT showed similar efficacy and safety.

Methods: The aim of our study was to demonstrate the long-term efficacy and safety of switching from BDT to QDT in KT recipients. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.079DOI Listing

Psychological Aspects and Psychopharmacologic Treatment in the Very Early Period After Kidney Transplantation: Role of a Multidisciplinary Approach.

Transplant Proc 2018 Jun 30. Epub 2018 Jun 30.

Nephrology, Dialysis and Transplant Unit, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.

Background: In the context of kidney transplantation (KT), multidisciplinary interventions, including assessment and management of psychosocial aspects, are important to improve transplant's outcome. The aim of this study was to describe a multidisciplinary team approach to KT, with a specific focus on early detection and treatment of psychological distress and psychopathologic conditions in the early phase postsurgery.

Methods: The multidisciplinary team in kidney transplantation was implemented in January 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183086
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http://dx.doi.org/10.1016/j.transproceed.2018.02.211DOI Listing
June 2018
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Impact of hospital admissions subsequent to renal transplantation on Italian regional resources: a retrospective study in the region Emilia-Romagna.

Minerva Urol Nefrol 2019 Jan 17. Epub 2019 Jan 17.

Department of Nursing, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Córdoba, Spain.

Background: Aim of this retrospective study was to investigate costs and resource consuming, expressed by diagnosis related groups (DRG), related only to hospitalizations of renal transplant recipients (RTRs) for all causes in the Region Emilia Romagna (RER) in Italy.

Methods: We included all hospital admissions of RTRs (ICD-9-CM code V420) between 2001 and 2015. We calculated number of admissions, RTRs and inhabitants of RER for each year, mean age, length of stay (LOS) in the hospital as total number of days, mean and median days, mean value of DRG and costs of admissions during the 15 year period of the study. Read More

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http://dx.doi.org/10.23736/S0393-2249.19.03280-6DOI Listing
January 2019

Minimally-Invasive Ureteral Reconstruction for Ureteral Complications of Kidney Transplants.

Urology 2019 Jan 14. Epub 2019 Jan 14.

Lahey Hospital & Medical Center, Burlington, MA, USA.

Objective: To present the technique, feasibility and results of minimally-invasive reconstruction of the transplanted ureter using the native ipsilateral ureter in post-transplant ureteral strictures and vesicoureteral reflux causing graft pyelonephritis. Ureteral complications after kidney transplantation represent a significant cause of morbidity potentially leading to graft dysfunction or loss.

Methods: A prospective database from October 2011 to August 2018 identified renal transplant recipients who underwent minimally-invasive pyeloureterostomies or ureteroureterostomies using the ipsilateral ureter. Read More

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http://dx.doi.org/10.1016/j.urology.2019.01.002DOI Listing
January 2019

Nomogram for predicting the likelihood of postoperative surgical complications in patients treated with partial nephrectomy: a prospective multicenter observational study (the RECORd 2 project).

BJU Int 2019 Jan 17. Epub 2019 Jan 17.

Department of Urology, University of Florence, Unit of Oncologic Minimally-Invasive Urology and Andrology, Careggi Hospital, Florence, Italy.

Purpose: To identify the meaningful predictors and to develop a nomogram of postoperative surgical complications in patients treated with partial nephrectomy.

Materials And Methods: We prospectively evaluated 4308 consecutive patients who had surgical treatment for renal tumors between 2013 and 2016 at 26 urological Italian centers (RECORd 2 project). A multivariable logistic regression for surgical complication was performed. Read More

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http://dx.doi.org/10.1111/bju.14680DOI Listing
January 2019

A note on rotigotine for restless legs syndrome after renal transplantation.

Mov Disord 2019 Jan;34(1):151-152

Neurogenetics, Instituto de Investigación Sanitaria de Santiago-SERGAS Santiago de Compostela, Spain.

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http://dx.doi.org/10.1002/mds.27574DOI Listing
January 2019

Combination of bortezomib in the induction, conditioning and consolidation with autologous hematopoietic stem cell transplantation in patients with immunoglobulin light chain amyloidosis.

Am J Hematol 2019 Jan 16. Epub 2019 Jan 16.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.

Bortezomib and autologous hematopoietic stem cell transplantation (ASCT) are both active regimen in AL amyloidosis. In this study, we assessed safety and efficacy of combination of bortezomib in the induction, conditioning and consolidation with ASCT in patients with newly diagnosed AL amyloidosis. Treatment schedule consisted of two cycles of bortezomib and dexamethasone (BD) induction therapy, ASCT treatment (the conditioning regimen consisted of melphalan and bortezomib), and four additional 21-day cycles of bortezomib treatment after ASCT. Read More

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http://dx.doi.org/10.1002/ajh.25404DOI Listing
January 2019
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Reactivation of resolved hepatitis B virus infection combined with nephrotic syndrome in a patient after allogeneic haematopoietic stem cell transplantation.

BMC Infect Dis 2019 Jan 16;19(1):57. Epub 2019 Jan 16.

Department of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou, China.

Background: After allogeneic haematopoietic stem cell transplantation (allo-HSCT), Hepatitis B virus reactivation (HBVr) can be observed in patients with previous resolved Hepatitis B virus (HBV) infections. Nephrotic syndrome (NS) is the main clinical manifestation of HBsAg-positive glomerulonephritis. However, the development of HBVr combined with NS after allo-HSCT is uncommon. Read More

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http://dx.doi.org/10.1186/s12879-019-3690-3DOI Listing
January 2019