150,409 results match your criteria Renal Transplantation


Cuba's contribution in the diagnosis of brain death/death by neurologic criteria.

Authors:
Calixto Machado

Clin Neurol Neurosurg 2021 May 5;206:106674. Epub 2021 May 5.

Institute of Neurology and Neurosurgery, Havana, Cuba. Electronic address:

I read with interest the paper by Lewis et al. to identify the countries in the Latin America/Caribbean Group of the United Nations (GRULAC) that have protocols for brain death/death by neurologic criteria (BD/DNC). Curiously, the authors don't mention Cuba, which has been one of the most active countries in the area, since the early '90s. Read More

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New markers for predictions of acute and chronic rejection and graft outcomes in kidney transplant recipients; HLA-G gene 3'UTR 14bp polymorphism and sHLA-G.

Gene 2021 May 10:145712. Epub 2021 May 10.

Department of Medical Biology and Genetics, Akdeniz University Faculty of Medicine, Antalya, Turkey; Tuncer Karpuzoglu Transplantation Center, Akdeniz University Hospital, Antalya, Turkey. Electronic address:

The aim of this study was to evaluate the relation of Human Leukocyte Antigen-G (HLA-G) 14 bp ins/del (insertion/deletion) polymorphism and soluble HLA-G (sHLA-G) level with rejection in kidney transplant recipients. The study was planned as a case-control study involving two hundred fifty kidney transplant recipients. The case group consisted of 125 (female/male:56/69) kidney transplant recipients diagnosed with acute (n=52) and chronic rejection (n=73). Read More

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Renal allograft DARCness in subclinical acute and chronic active ABMR.

Transpl Int 2021 May 13. Epub 2021 May 13.

Department of Pathology, Medical University Vienna, Vienna, Austria.

Background: Gene expression profiling of renal allograft biopsies revealed the Duffy antigen receptor for chemokines (DARC) as being strikingly upregulated in antibody-mediated rejection (ABMR). DARC has previously been shown to be associated with endothelial injury. This study aimed at assessing the value of DARC immunohistochemistry as diagnostic marker in ABMR. Read More

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The Costs of Organ Procurement - Another Case of Efficiency Versus Equity.

Authors:
Martin Howell

Transplantation 2021 Feb 5. Epub 2021 Feb 5.

1 Sydney School of Public Health, The University of Sydney, Sydney, NSW 2006 2 Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, NSW 2145.

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February 2021

Kidney Allograft Fibrosis: Diagnostic and Therapeutic Strategies.

Transplantation 2021 Feb 8. Epub 2021 Feb 8.

1 Division of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Germany 2 Institute of Experimental Medicine and Systems Biology, University Hospital RWTH Aachen, Germany 3 Department of Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands.

Interstitial fibrosis with tubule atrophy (IF/TA) is the response to virtually any sustained kidney injury and correlates inversely with kidney function and allograft survival. IF/TA is driven by various pathways that include hypoxia, renin-angiotensin-aldosterone system, transforming growth factor (TGF)-β signaling, cellular rejection, inflammation and others. In this review we will focus on key pathways in the progress of renal fibrosis, diagnosis and therapy of allograft fibrosis. Read More

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February 2021

Advances in kidney preservation techniques and their application in clinical practice.

Transplantation 2021 Mar 18. Epub 2021 Mar 18.

Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

The use of cold preservation solutions to rapidly flush and cool the kidney followed by static cold storage (SCS) in ice has been the standard kidney preservation technique for the last 50 years. Nonetheless, changing donor demographics that include organs from extended criteria donors (ECDs) and donation after circulatory death (DCD) donors have led to the adoption of more diverse techniques of preservation. Comparison of hypothermic machine perfusion (HMP) and SCS techniques for deceased donor kidneys has long been debated and is still contested by some. Read More

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Role of Highly Sensitive Nucleic Acid Amplification Testing for Plasma Cytomegalovirus DNA Load in Diagnosis of Cytomegalovirus Gastrointestinal Disease Among Kidney Transplant Recipients.

Transpl Infect Dis 2021 May 13:e13635. Epub 2021 May 13.

Excellence Center for Organ Transplantation, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: High plasma cytomegalovirus (CMV) DNA load is generally associated with CMV tissue-invasive disease in solid organ transplant recipients. However, some tissue-invasive diseases, especially CMV gastrointestinal (GI) disease, have undetectable to very low plasma CMV DNA loads. Highly sensitive nucleic acid amplification testing (NAAT) has been increasingly used to quantify low-level CMV DNA loads. Read More

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Clinical impact of sexual dimorphism in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

Liver Int 2021 May 12. Epub 2021 May 12.

Gastroenterology Unit, Azienda Ospedaliero-Universitaria Policlinico di Modena, Largo del Pozzo, 71, 41125, Modena, Italy.

NAFLD/NASH is a sex dimorphic disease, with a general higher prevalence in men. Women are at reduced risk of NAFLD compared to men in fertile age, whereas after menopause women have a comparable prevalence of NAFLD as men. Indeed, sexual category, sex hormones and gender habits interact with numerous NAFLD factors including cytokines, stress, and environmental factors and alter the risk profiles and phenotypes of NAFLD. Read More

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HLA major allele group frequencies in a diverse population of the Free State Province, South Africa.

Heliyon 2021 Apr 21;7(4):e06850. Epub 2021 Apr 21.

Department of Haematology and Cell Biology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.

Background: Human Leucocyte Antigens (HLA) play a vital role in disease pathogenesis and transplant rejection. HLA-typing is a useful tool in predicting disease progression and to identify potential organ donors. Due to human migration and known ethnic variation, frequent targeted HLA sequencing of specific populations is crucial to increase their representation in global reference panels. Read More

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Impact of Acute Kidney Injury on Critically Ill Children and Neonates.

Front Pediatr 2021 26;9:635631. Epub 2021 Apr 26.

Pediatric Nephrology and Hypertension Division, Sidra Medicine, Doha, Qatar.

Acute kidney injury (AKI) is a clinical syndrome that manifests as an abrupt impairment of kidney function. AKI is common in critically ill pediatric patients admitted to the pediatric intensive care units. AKI is a deleterious complication in critically ill children as it is associated with increased morbidity and mortality. Read More

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International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Western Europe.

Kidney Int Suppl (2011) 2021 May 12;11(2):e106-e118. Epub 2021 Apr 12.

Intensive Care Nephrology and Transplantation Department, Hopital Tenon, Assistance Publique-Hopitaux de Paris, Paris, France.

Populations in the high-income countries of Western Europe are aging due to increased life expectancy. As the prevalence of diabetes and obesity has increased, so has the burden of kidney failure. To determine the global capacity for kidney replacement therapy and conservative kidney management, the International Society of Nephrology conducted multinational, cross-sectional surveys and published the findings in the International Society of Nephrology Global Kidney Health Atlas. Read More

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International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in South Asia.

Kidney Int Suppl (2011) 2021 May 12;11(2):e97-e105. Epub 2021 Apr 12.

George Institute for Global Health, University of New South Wales (UNSW), New Delhi, India.

Information about disease burden and the available infrastructure and workforce to care for patients with kidney disease was collected for the second edition of the International Society of Nephrology Global Kidney Health Atlas. This paper presents findings for the 8 countries in the South Asia region. The World Bank categorizes Afghanistan and Nepal as low-income; Bangladesh, Bhutan, India, and Pakistan as lower-middle-income; and Sri Lanka and the Maldives as upper-middle-income countries. Read More

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International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Oceania and South East Asia.

Kidney Int Suppl (2011) 2021 May 12;11(2):e86-e96. Epub 2021 Apr 12.

Department of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Oceania and South East Asia (OSEA) is a socioeconomically, culturally, and ethnically diverse region facing a rising epidemic of noncommunicable diseases, including chronic kidney disease (CKD). The second iteration of the International Society of Nephrology Global Kidney Health Atlas aimed to provide a comprehensive evaluation of kidney care in OSEA. Of the 30 countries/territories in OSEA, 15 participated in the survey, representing 98. Read More

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International Society of Nephrology Global Kidney Health Atlas: structures, organization and services for the management of kidney failure in North and East Asia.

Kidney Int Suppl (2011) 2021 May 12;11(2):e77-e85. Epub 2021 Apr 12.

Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China.

Kidney failure (KF) is a public health problem in all regions of the world. We aim to provide comprehensive information regarding the disease burden of KF and capacity for providing optimal care in the International Society of Nephrology North and East Asia region based on data from the International Society of Nephrology Global Kidney Health Atlas project. Seven of eight jurisdictions participated, and wide variation was found in terms of KF burden and care capacity. Read More

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International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in North America and the Caribbean.

Kidney Int Suppl (2011) 2021 May 12;11(2):e66-e76. Epub 2021 Apr 12.

Division of Nephrology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

The International Society of Nephrology established the Global Kidney Health Atlas project to define the global capacity for kidney replacement therapy and conservative kidney care, and this second iteration was to describe the availability, accessibility, quality, and affordability of kidney failure (KF) care worldwide. This report presents results for the International Society of Nephrology North America and the Caribbean region. Relative to other regions, the North America and Caribbean region had better infrastructure and funding for health care and more health care workers relative to the population. Read More

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International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Newly Independent States and Russia.

Kidney Int Suppl (2011) 2021 May 12;11(2):e57-e65. Epub 2021 Apr 12.

High Technology Medical Center University Clinic, Tbilisi State Medical University, Tbilisi, Georgia.

The International Society of Nephrology Global Kidney Health Atlas analyzed the current state of kidney care in Newly Independent States and Russia. Our results demonstrated that the Newly Independent States and Russia region was not an exception and showed the same effect of chronic kidney disease on health and its outcomes, facing many difficulties and challenges in terms of improving kidney care across the countries. This work summarized and presented demographics, health information systems, statistics, and national health policy of the region, as well as characteristics of the burden of chronic kidney disease and kidney failure (KF) of participating countries. Read More

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International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in the Middle East.

Kidney Int Suppl (2011) 2021 May 12;11(2):e47-e56. Epub 2021 Apr 12.

Division of Nephrology, Department of Medicine, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran.

Kidney failure is the permanent impairment of kidney function associated with increased morbidity, hospitalization, and requirement for kidney replacement therapy. A total of 11 countries in the Middle East region (84.6%) responded to the survey. Read More

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International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Latin America.

Kidney Int Suppl (2011) 2021 May 12;11(2):e35-e46. Epub 2021 Apr 12.

Department of Nephrology, Metro South and Ipswich Nephrology and Transplant Services, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Latin America is a region with a widely variable socioeconomic landscape, facing a surge in noncommunicable diseases, including chronic kidney disease and kidney failure, exposing significant limitations in the delivery of care. Despite region-wide efforts to explore and address these limitations, much uncertainty remains as to the capacity, accessibility, and quality of kidney failure care in Latin America. Through this second iteration of the International Society of Nephrology Global Kidney Health Atlas, we aimed to report on these indicators to provide a comprehensive map of kidney failure care in the region. Read More

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International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Eastern and Central Europe.

Kidney Int Suppl (2011) 2021 May 12;11(2):e24-e34. Epub 2021 Apr 12.

Division of Nephrology, Bezmialem Vakif University, Istanbul, Turkey.

Provision of adequate kidney care for patients with chronic kidney disease or kidney failure (KF) is costly and requires extensive resources. There is an inequality in the global distribution of wealth and resources needed to provide this care. In this second iteration of the International Society of Nephrology Global Kidney Health Atlas, we present data for countries in Eastern and Central Europe. Read More

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International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Africa.

Kidney Int Suppl (2011) 2021 May 12;11(2):e11-e23. Epub 2021 Apr 12.

Urinary Tract Diseases Department, Faculty of Medicine and Pharmacy of Casablanca, University Hassan II of Casablanca, Casablanca, Morocco.

Despite positive economic forecasts, stable democracies, and reduced regional conflicts since the turn of the century, Africa continues to be afflicted by poverty, poor infrastructure, and a massive burden of communicable diseases such as HIV, malaria, tuberculosis, and diarrheal illnesses. With the rising prevalence of chronic kidney disease and kidney failure worldwide, these factors continue to hinder the ability to provide kidney care for millions of people on the continent. The International Society of Nephrology Global Kidney Health Atlas project was established to assess the global burden of kidney disease and measure global capacity for kidney replacement therapy (dialysis and kidney transplantation). Read More

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Global variation in kidney care: national and regional differences in the care and management of patients with kidney failure.

Kidney Int Suppl (2011) 2021 May 12;11(2):e1-e3. Epub 2021 Apr 12.

Department of Nephrology, Metro South and Ipswich Nephrology and Transplant Services (MINTS), Princess Alexandra Hospital, Brisbane, Queensland, Australia.

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Exercise training in patients after kidney transplantation.

Clin Kidney J 2021 Apr 2;14(Suppl 2):ii15-ii24. Epub 2021 Feb 2.

Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.

Kidney transplantation is the treatment of choice for patients with end-stage renal disease. Next to the risk of allograft failure, major obstacles for disease-free survival after kidney transplantation include a higher incidence of cancer, infection and cardiovascular events. Risk factors for adverse clinical outcomes include pre-existent comorbidities, the introduction of an immunodeficient status and (lack of) lifestyle changes after transplantation. Read More

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Long-Term Care of the Pediatric Kidney Transplant Recipient.

Clin J Am Soc Nephrol 2021 May 12. Epub 2021 May 12.

Department of Pediatrics, McGill University, Montreal, Quebec, Canada

Pediatric kidney transplant recipients are distinguished from adult recipients by the need for many decades of graft function, the potential effect of CKD on neurodevelopment, and the changing immune environment of a developing human. The entire life of an individual who receives a transplant as a child is colored by their status as a transplant recipient. Not only must these young recipients negotiate all of the usual challenges of emerging adulthood (transition from school to work, romantic relationships, achieving independence from parents), but they must learn to manage a life-threatening medical condition independently. Read More

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A systematic review and meta-analysis of enzyme-linked immunosorbent spot (ELISPOT) assay for BK polyomavirus immune response monitoring after kidney transplantation.

J Clin Virol 2021 Apr 28;140:104848. Epub 2021 Apr 28.

Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Erasmus MC Transplantation Institute, Rotterdam, Netherlands. Electronic address:

BK virus (BKV) infection after kidney transplantation can cause BKV nephropathy (BKVAN) resulting in graft dysfunction and allograft loss. The treatment for BKVAN is reduction of the immunosuppressive load which increases the risk of kidney transplant rejection. There is no biomarker to monitor BKV activity besides BK viral load. Read More

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Renal Normothermic Machine Perfusion: The Road Toward Clinical Implementation of a Promising Pretransplant Organ Assessment Tool.

Transplantation 2021 May 11. Epub 2021 May 11.

Department of Surgery - Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands Laboratory of Abdominal Transplantation, Transplantation Research Group, Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium.

The increased utilization of high-risk renal grafts for transplantation requires optimization of pretransplant organ assessment strategies. Current decision-making methods to accept an organ for transplantation lack overall predictive power and always contain an element of subjectivity. Normothermic machine perfusion (NMP) creates near-physiological conditions, which might facilitate a more objective assessment of organ quality prior to transplantation. Read More

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Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study.

Clin Transl Gastroenterol 2021 May 11;12(5):e00359. Epub 2021 May 11.

Liver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

Introduction: Urinary neutrophil gelatinase-associated lipocalin (NGAL) has shown promise in differentiating acute tubular necrosis (ATN) from other types of acute kidney injuries (AKIs) in cirrhosis, particularly hepatorenal syndrome (HRS). However, NGAL is not currently available in clinical practice in North America.

Methods: Urinary NGAL was measured in a prospective cohort of 213 US hospitalized patients with decompensated cirrhosis (161 with AKI and 52 reference patients without AKI). Read More

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Contrast-enhanced ultrasound of transplant organs - liver and kidney - in children.

Pediatr Radiol 2021 May 12. Epub 2021 May 12.

Department of Radiology and Medical Imaging, University of Virginia Children's Hospital, Charlottesville, VA, USA.

Ultrasound (US) is the first-line imaging tool for evaluating liver and kidney transplants during and after the surgical procedures. In most patients after organ transplantation, gray-scale US coupled with color/power and spectral Doppler techniques is used to evaluate the transplant organs, assess the patency of vascular structures, and identify potential complications. In technically difficult or inconclusive cases, however, contrast-enhanced ultrasound (CEUS) can provide prompt and accurate diagnostic information that is essential for management decisions. Read More

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Optimizing the Selection of Patients for Simultaneous Liver-Kidney Transplant.

Clin Liver Dis 2021 Feb 16;25(1):89-102. Epub 2020 Oct 16.

Division of Gastroenterology and Hepatology, Michigan Medicine, University of Michigan, 3912 Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:

Simultaneous liver-kidney transplantation has increased significantly in the Model for End Stage Liver Disease era. The transplantation policy has evolved significantly since the implementation of allocation based on the Model for End Stage Liver Disease. Current policy takes into account the medical eligibility criteria for simultaneous liver-kidney transplantation listing. Read More

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February 2021

Obstetric and long-term graft outcomes in pregnant kidney transplant recipients: a single-center experience.

Clin Transplant 2021 May 12:e14349. Epub 2021 May 12.

Gazi University, Faculty of Medicine, Department of Nephrology, Ankara, Turkey.

Background: Kidney transplantation (KT) is the best option for many women with end-stage renal disease desiring pregnancy. The aim of this study was to investigate obstetric and graft outcomes among KT recipient women in our center.

Methods: Maternal and fetal data were assessed in 29 pregnancies of 18 female KT recipients. Read More

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Editorial Comment to Venous reconstruction using a Y-shaped saphenous vein in kidney transplantation: A report of three cases.

Authors:
Tomokazu Shimizu

IJU Case Rep 2021 May 23;4(3):149-150. Epub 2021 Mar 23.

Department of Transplant Surgery Kidney Center Toda Chuo General Hospital Saitama Japan.

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