158,759 results match your criteria Renal Transplantation


Clinical and Economic Burden of Multiple dsDNA Viral Infections After Allogeneic Hematopoietic Cell Transplantation.

Transplant Cell Ther 2022 Jun 25. Epub 2022 Jun 25.

Knight Cancer Institute, Oregon Health & Science University, Portland, OR.

Background: Conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT) are immunosuppressive and increase the risk for reactivation of and infection with double-stranded deoxyribonucleic acid (dsDNA) viruses, which contribute to morbidity and mortality after allo-HCT.

Objective: This retrospective observational study evaluated the association of dsDNA viral infections with clinical outcomes, health resource utilization (HRU), and health care reimbursement after allo-HCT.

Study Design: Patients who underwent allo-HCT (2012 through 2017) were identified from a US open-source claims database (Decision Resource Group Real-World Evidence Data Repository; N=13,363) and categorized according to presence or absence of dsDNA viral infection, defined as having ≥1 diagnosis code for CMV, AdV, HHV-6, or BKV/EBV/JCV (grouped together given lack of specific diagnoses codes) within 1 year after allo-HCT. Read More

View Article and Full-Text PDF

Personalized anti-rejection therapy with alemtuzumab for kidney transplant recipients.

Pharmacogenomics 2022 Jun 28. Epub 2022 Jun 28.

Erasmus MC Transplant Institute, Rotterdam, The Netherlands.

View Article and Full-Text PDF

Neuropsychological Assessment of Cognitive Impairment in Kidney Transplantation (NAsKiT) and its related risk factors: a study protocol.

J Nephrol 2022 Jun 28. Epub 2022 Jun 28.

Department of Neurology, University Hospital Giessen and Marburg, Justus-Liebig-University of Giessen, Giessen, Germany.

Background: Association of cognitive impairment with chronic kidney disease has been reported over the last decade. Individuals show better cognitive performance after kidney transplantation than individuals on dialysis but are more likely to be affected by cognitive impairment than age-matched comparison groups. Better knowledge of the prevalence as well as course and profile of cognitive impairment is important for the design of future studies assessing the clinical impact of cognitive impairment and developing management strategies. Read More

View Article and Full-Text PDF

The Kidney Transplant Equity Index: Improving Racial and Ethnic Minority Access to Transplantation.

Ann Surg 2022 Jun 28. Epub 2022 Jun 28.

Cincinnati Research in Outcomes and Safety in Surgery (CROSS) Research Group. Department of Surgery, University of Cincinnati College of Medicine. CARE/Crawley Building, Suite E-870 Eden Avenue, Cincinnati, Ohio 45267.

Objectives: To develop a scalable metric which quantifies kidney transplant (KT) centers' performance providing equitable access to KT for minority patients, based on the individualized pre-listing prevalence of End-Stage Renal Disease (ESRD).

Summary Background Data: Racial and ethnic disparities for access to transplant in patients with ESRD are well described; however, variation in care among KT centers remains unknown. Furthermore, no mechanism exists that quantifies how well a KT center provides equitable access to KT for minority patients with ESRD. Read More

View Article and Full-Text PDF

COVID-19-associated acute appendicitis in adults. A report of five cases and a review of the literature.

Exp Ther Med 2022 Jul 1;24(1):482. Epub 2022 Jun 1.

Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece.

The novel coronavirus has negatively affected patients and healthcare systems globally. Individuals with coronavirus disease 2019 (COVID-19) experience a wide range of respiratory symptoms, from mild flu-like symptoms to severe and potentially fatal pneumonia. Some patients report gastrointestinal symptoms, such as nausea, vomiting and abdominal pain in addition to the respiratory symptoms or as a separate presentation. Read More

View Article and Full-Text PDF

Renal sarcoidosis.

J Nephrol 2022 Jun 27. Epub 2022 Jun 27.

Independent Researcher, via Ampere 126, 20131, Milan, Italy.

Sarcoidosis is a systemic inflammatory disease of unknown etiology. The pathogenesis rests on an aberrant T cell response to unidentified antigens in individuals predisposed by genetic and environmental factors. Increased expression of polarized macrophages and disequilibrium between effector and regulator T cells contribute to the formation of noncaseating granulomas, that are frequently found in affected organs. Read More

View Article and Full-Text PDF

Let-7a mimic transfection reduces chemotherapy-induced damage in a mouse ovarian transplantation model.

Sci Rep 2022 Jun 27;12(1):10863. Epub 2022 Jun 27.

Research Laboratory in Human Reproduction, Faculty of Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Pharmacological approaches offer a non-invasive and promising option for fertility preservation in young female cancer patients undergoing gonadotoxic therapy. The GnRH-agonists are the only clinically available drugs in this indication, but their use and mechanisms of protection are still controversial. Recently, we have investigated new targeted drugs based on microRNA (miRNA) replacement therapy, and have identified the let-7a miRNA as candidate for fertility preservation strategies. Read More

View Article and Full-Text PDF

Acute kidney injury secondary to urinary tract infection in kidney transplant recipients.

Sci Rep 2022 Jun 27;12(1):10858. Epub 2022 Jun 27.

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wrocław, 50-556, Poland.

Acute kidney injury (AKI) in kidney transplant recipients (KTRs) is a common, yet poorly investigated, complication of urinary tract infections (UTI) and urosepsis. A retrospective comparative analysis was performed, recruiting 101 KTRs with urosepsis, 100 KTRs with UTI, and 100 KTRs without history of UTI or sepsis. The incidences of AKI in the urosepsis and UTI groups were 75. Read More

View Article and Full-Text PDF

Cytomegaloviral Retinitis in a Heart Transplant Patient: Case Report and Review of the Literature.

Transplant Proc 2022 Jun 24. Epub 2022 Jun 24.

Departments of Ophthalmology, Transplantology, and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.

Cytomegalovirus (CMV) poses a significant threat to solid organ transplant recipients (SOTR). The incidence of CMV disease in SOTR varies according to immunosuppressive therapy, antiviral prophylaxis, donor and recipient serologic compatibility, and the transplanted organ: 9% to 23%, 22% to 29% and 8% to 32% after heart, liver and kidney transplant, respectively. CMV retinitis (CMVR) is a rare manifestation of CMV with a high risk of blindness. Read More

View Article and Full-Text PDF

Hepatorenal Syndrome and Other Post-Liver Transplantation Complications: Case Studies and Literature Review.

Transplant Proc 2022 Jun 24. Epub 2022 Jun 24.

Clinic of General, Liver and Transplant Surgery, University Hospital No 1 in Bydgoszcz named after Dr A. Jurasz, Collegium Medicum, Nicolaus Copernicus University in Toruń, Poland.

Hepatorenal syndrome (HRS) was originally defined as a renal dysfunction caused by a decreased renal perfusion due to hemodynamic disturbances in the arterial circulation and an excessive activity of endogenous vasoactive systems in the course of cirrhosis. Considering the latest research, this syndrome may have a more complex pathomechanism. Equally often as in cirrhosis, HRS develops after orthotopic liver transplantation (OLTx) and worsens the prognosis significantly increasing mortality rates in this patient population. Read More

View Article and Full-Text PDF

Analysis of Complications and Recipients' and Graft Survival in Patients 60 Years of Age and Older in the Long-Term Follow-up Period After Kidney Transplant: A Single-Center, Paired Kidney Analysis.

Transplant Proc 2022 Jun 24. Epub 2022 Jun 24.

Department of General, Vascular and Transplant Surgery, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.

Background: Long-term results of kidney transplant (KTx) in older patients may differ from younger recipients owing to increased cardiovascular comorbidities. The study aimed to analyze surgical and nonsurgical complications that develop in the long-term follow-up period after KTx, and factors that influence results of KTx in recipients aged 60 years and older (≥60) compared with younger recipients (<60).

Methods: One hundred seventy-five patients aged ≥60 years and 175 patients aged <60 years who received a kidney graft from the same deceased donor were enrolled in the study. Read More

View Article and Full-Text PDF

Invited commentary: Focusing upstream to improve equity in living donor transplantation: From theory to practice in kidney disease.

Surgery 2022 Jun 24. Epub 2022 Jun 24.

Division of Transplantation, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address:

View Article and Full-Text PDF

A tool for decision-making in kidney transplant candidates with poor prognosis to receive deceased donor transplantation in the United States.

Kidney Int 2022 Jun 24. Epub 2022 Jun 24.

Division of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York; The Columbia University Renal Epidemiology Group, Columbia University, New York, New York.

The primary outcomes for kidney transplant candidates are receipt of deceased or living donor transplant, death or removal from the waiting list. Here, we conducted a retrospective analysis of national Scientific Registry of Transplant Recipients data to evaluate outcomes for 208,717 adult kidney transplant candidates following the 2014 Kidney Allocation System in the United States. Competing risks models were utilized to evaluate Time to Equivalent Risk (TiTER) of deceased donor transplantation (DDTX) and death versus waitlist removal. Read More

View Article and Full-Text PDF

Cost-Effectiveness Analysis: Personal Systems Approach in Improving Medication Adherence in Adult Kidney Transplant Patients.

J Healthc Qual 2022 Jul-Aug 01;44(4):240-252

Abstract: Interventions to improve medication nonadherence in transplantation have recently moved from a focus on motivation and intention, to a focus on person-level quality improvement strategies. These strategies link adherence to established daily routines, environmental cues, and supportive people. The objective of this evaluation was to estimate the cost of implementation and the cost-effectiveness of a person-level intervention shown to increase medication adherence. Read More

View Article and Full-Text PDF

A Prevascularized Sinus Tract on the Liver Surface for Islet Transplantation.

Transplantation 2022 Jun 27. Epub 2022 Jun 27.

Department of Hepatobiliary Surgery, The First Hospital of China Medical University, Shenyang, China.

Background: The lack of a suitable transplantation site has become a bottleneck restricting the development of islet transplantation.

Methods: In this study, for the first time, a prevascularized sinus tract (PST) for islet transplantation was constructed in a mouse model by temporarily embedding a 4× silk thread between the liver surface and the attached decellularized human amniotic membrane. After which, the characteristics of the PST and the function of the islet graft within the PST were evaluated. Read More

View Article and Full-Text PDF

A survey-based triage tool to identify patients potentially eligible for referral to an advanced heart failure centre.

ESC Heart Fail 2022 Jun 27. Epub 2022 Jun 27.

Department of Cardiovascular Medicine, Mater Misericordiae University Hospital, Dublin, Ireland.

Aims: Accurate prevalence data for ambulatory advanced heart failure (HF) in European countries remains limited. This study was designed to identify the population of patients potentially eligible for referral for assessment for advanced surgical HF therapies to a National advanced HF and cardiac transplant centre.

Methods And Results: A survey comprising 13 potential clinical markers of advanced HF was developed, modified from the 'I NEED HELP' tool from the 2018 position statement of the Heart Failure Association of the European Society of Cardiology, and distributed to all HF clinic services (secondary and tertiary units) nationwide. Read More

View Article and Full-Text PDF

Harnessing the B Cell Response in Kidney Transplantation - Current State and Future Directions.

Front Immunol 2022 9;13:903068. Epub 2022 Jun 9.

Duke Transplant Center, Department of Surgery, Duke University School of Medicine, Durham, NC, United States.

Despite dramatic improvement in kidney transplantation outcomes over the last decades due to advent of modern immunosuppressive agents, long-term outcomes remain poor. Antibody-mediated rejection (ABMR), a B cell driven process, accounts for the majority of chronic graft failures. There are currently no FDA-approved regimens for ABMR; however, several clinical trials are currently on-going. Read More

View Article and Full-Text PDF

Case Report: Azathioprine: An Old and Wronged Immunosuppressant.

Front Immunol 2022 10;13:903012. Epub 2022 Jun 10.

School of Pharmacy, The University of Queensland, Woolloongabba, QLD, Australia.

Mycophenolate rapidly substituted azathioprine (AZA) in transplant immunosuppression regimens since the 1990s, when early clinical trials indicated better outcomes, although opposite results were also observed. However, none of these trials used the well-established optimization methods for AZA dosing, namely, thiopurine methyltransferase pharmacogenetics combined with monitoring of the thiopurine metabolites 6-thioguanine nucleotides (6-TGN) and 6-methylmercaptopurine (6-MMP). Resistance to optimize AZA therapy remains today in transplant therapy, despite the fact that thiopurine metabolite testing is being used by other medical disciplines with evident improvement in clinical results. Read More

View Article and Full-Text PDF

Xenotransplantation: A New Era.

Front Immunol 2022 9;13:900594. Epub 2022 Jun 9.

Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, United States.

Organ allotransplantation has now reached an impassable ceiling inherent to the limited supply of human donor organs. In the United States, there are currently over 100,000 individuals on the national transplant waiting list awaiting a kidney, heart, and/or liver transplant. This is in contrast with only a fraction of them receiving a living or deceased donor allograft. Read More

View Article and Full-Text PDF

Non-pulmonary complications after lung transplantation: part II.

Indian J Thorac Cardiovasc Surg 2022 Jul 12;38(Suppl 2):290-299. Epub 2021 Oct 12.

Lung Transplant Program, University of Texas Southwestern Medical Center, 5939 Harry Hines Blvd. Suite 603, Dallas, TX 75235-8550 USA.

Lung transplantation (LT) is a viable therapeutic option in the treatment of advanced lung disease. With improvements in post-transplant survival, complications involving different organ systems after LT are increasingly seen. While non-infectious, extrapulmonary complications after LT are not frequently responsible for early post-transplant mortality, they significantly impact the quality of life and long-term survival. Read More

View Article and Full-Text PDF

Hyperammonemia in lung transplant patients and its management: a review.

Indian J Thorac Cardiovasc Surg 2022 Jul 14;38(Suppl 2):335-346. Epub 2022 Mar 14.

Division of Cardiothoracic Surgery, University of Kentucky, Lexington, KY USA.

Objective: To synthesize the evidence for incidence, pathophysiology, etiology, and protocol-based management of hyperammonemia in lung transplant patients.

Background: Elevated ammonia levels are toxic to the brain, and hyperammonemia results in a potentially fatal complication for lung transplant recipients. The hallmark of this condition is ammonia production being way out of proportion to the degree of liver derangement. Read More

View Article and Full-Text PDF

Non-pulmonary complications after lung transplantation: Part I.

Indian J Thorac Cardiovasc Surg 2022 Jul 8;38(Suppl 2):280-289. Epub 2021 Oct 8.

Lung Transplant Program, University of Texas Southwestern Medical Center, 5939 Harry Hines Blvd. Suite 603, Dallas, TX 75235-8550 USA.

Lung transplantation (LT) is a viable therapeutic option in the treatment of advanced lung disease. With improvements in post-transplant survival, complications involving different organ systems after LT are increasingly seen. While non-infectious, extrapulmonary complications after LT are not frequently responsible for early post-transplant mortality, they significantly impact the quality of life and long-term survival. Read More

View Article and Full-Text PDF

Indications, Complications, and Outcomes of Cardiac Surgery After Heart Transplantation: Results From the Cash Study.

Front Cardiovasc Med 2022 9;10:879612. Epub 2022 Jun 9.

Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.

Background: Allograft pathologies, such as valvular, coronary artery, or aortic disease, may occur early and late after cardiac transplantation. Cardiac surgery after heart transplantation (CASH) may be an option to improve quality of life and allograft function and prolong survival. Experience with CASH, however, has been limited to single-center reports. Read More

View Article and Full-Text PDF

Detecting, preventing and treating non-adherence to immunosuppression after kidney transplantation.

Clin Kidney J 2022 Jul 14;15(7):1253-1274. Epub 2022 Jan 14.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Medication non-adherence (MNA) is a major issue in kidney transplantation and it is associated with increased risk of rejection, allograft loss, patients' death and higher healthcare costs. Despite its crucial importance, it is still unclear what are the best strategies to diagnose, prevent and treat MNA. MNA can be intentional (deliberate refusal to take the medication as prescribed) or unintentional (non-deliberate missing the prescribed medication). Read More

View Article and Full-Text PDF

Epidemiology of native kidney disease in Flanders: results from the FCGG kidney biopsy registry.

Clin Kidney J 2022 Jul 29;15(7):1361-1372. Epub 2022 Jan 29.

Department of Microbiology, Immunology and Transplantation, Laboratory of Molecular Immunology, Rega Institute, KU Leuven, Leuven, Belgium.

Background: The Flemish Collaborative Glomerulonephritis Group (FCGG) registry is the first population-based native kidney biopsy registry in Flanders, Belgium. In this first analysis, we report on patient demographics, frequency distribution and incidence rate of biopsied kidney disease in adults in Flanders.

Methods: From January 2017 to December 2019, a total of 2054 adult first native kidney biopsies were included. Read More

View Article and Full-Text PDF

Complex Vascular Reconstruction of an En Bloc Pediatric Kidney Damaged during Organ Procurement.

Case Rep Transplant 2022 16;2022:3242809. Epub 2022 Jun 16.

Department of Surgery, University of Miami, Miami, FL, USA.

En bloc pediatric kidney (EBPK) allografts are a potential solution to expand the organ donor pool; however, EBPK transplantation has been traditionally considered suboptimal due to concerns of perioperative vascular and urologic complications. Accidental organ or vasculature injury during harvest is not uncommon; however, this does not necessarily mean that the organ should be discarded. Careful vascular reconstruction can be performed using donor vascular grafts, salvaging the organ without stenosis or thrombosis of the vessels. Read More

View Article and Full-Text PDF

Various Techniques and Outcomes of Arterial Anastomosis in Live Renal Transplant: An Institutional Experience.

Cureus 2022 May 23;14(5):e25262. Epub 2022 May 23.

Urology, Madras Medical College, Chennai, IND.

Introduction Renal transplantation with multiple arteries is associated with a major index of surgical complications. Relevant papers and meta-analyses have shown relatively more vascular and urological complications in transplant of donor kidneys with multiple arteries. In live donor grafts due to the unavailability of a carrel patch, several techniques for bench and in situ reconstruction have been described in order to reduce the incidence of these vascular complications. Read More

View Article and Full-Text PDF

Fasting Ramadan in Chronic Kidney Disease (CKD), Kidney Transplant and Dialysis Patients: Review and Update.

Cureus 2022 May 24;14(5):e25269. Epub 2022 May 24.

General Internal Medicine, Hamad General Hospital, Doha, QAT.

Chronic kidney disease (CKD) is a common disease in the Islamic regions. Dehydration occurs after prolonged fasting, particularly in hot and humid climates. In the Arabic months' calendar, Ramadan is a month of maximum given deeds, where Muslims are required to fast from dawn till sunset. Read More

View Article and Full-Text PDF

Safety and efficacy of coronavirus disease-19 vaccines in chronic kidney disease patients under maintenance hemodialysis: A systematic review.

Health Sci Rep 2022 Jul 16;5(4):e700. Epub 2022 Jun 16.

Department of Nephrology and Transplantation Medicine, Institute of Medicine Tribhuvan University Maharajgunj Nepal.

Background And Aims: Patients on maintenance dialysis are a high-risk, immune-compromised population with 15%-25% coronavirus disease (COVID-19) mortality rate that has been underrepresented in COVID-19 vaccination clinical trials. The aim of study was to review of those studies to determine the safety and efficacy of the COVID-19 vaccination in chronic kidney disease (CKD) patients receiving maintenance hemodialysis systematically.

Methods: The effectiveness was assessed by looking at the humoral and cellular responses. Read More

View Article and Full-Text PDF