143,896 results match your criteria Renal Transplantation


The efficacy of transversus abdominis plane block with or without dexmedetomidine for postoperative analgesia in renal transplantation. A randomized controlled trial.

Int J Surg 2020 Jun 2. Epub 2020 Jun 2.

Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, No.58, Zhongshan 2nd Road, 510080, Guangzhou, China. Electronic address:

Background: Current options for effective postoperative analgesia after renal transplantation are limited, due to altered renal clearance and the risk of renal damage. This study compared the analgesic effect of the transversus abdominis plane block, with or without dexmedetomidine, in renal transplant recipients.

Materials And Methods: This prospective randomized double-blinded clinical trial was performed from November 2014 to March 2017. Read More

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http://dx.doi.org/10.1016/j.ijsu.2020.05.073DOI Listing

Prescription Patterns of Opioids and Non-Steroidal Anti-Inflammatory Drugs in the First Year After Living Kidney Donation: An Analysis of U.S. Registry and Pharmacy Fill Records.

Clin Transplant 2020 Jun 5:e14000. Epub 2020 Jun 5.

Center for Abdominal Transplantation, Saint Louis University, St. Louis, MO, USA.

We examined a novel database linking national donor registry identifiers to records from a U.S. pharmaceutical claims warehouse (2007-2015) to describe opioid and NSAID prescription patterns among LKDs during the first year postdonation, divided into three periods: 0-14 days, 15-182 days, and 183-365 days. Read More

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http://dx.doi.org/10.1111/ctr.14000DOI Listing

Using machine learning models to predict the initiation of renal replacement therapy among chronic kidney disease patients.

PLoS One 2020 5;15(6):e0233976. Epub 2020 Jun 5.

Taipei Medical University, Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei, Taiwan.

Starting renal replacement therapy (RRT) for patients with chronic kidney disease (CKD) at an optimal time, either with hemodialysis or kidney transplantation, is crucial for patient's well-being and for successful management of the condition. In this paper, we explore the possibilities of creating forecasting models to predict the onset of RRT 3, 6, and 12 months from the time of the patient's first diagnosis with CKD, using only the comorbidities data from National Health Insurance from Taiwan. The goal of this study was to see whether a limited amount of data (including comorbidities but not considering laboratory values which are expensive to obtain in low- and medium-income countries) can provide a good basis for such predictive models. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233976PLOS

The role of protocol biopsies after pediatric kidney transplantation.

Medicine (Baltimore) 2020 Jun;99(23):e20522

Department of Pediatric Nephrology.

Data on protocol biopsies (PBs) after pediatric kidney transplantation are rare.We evaluated 6-month post-transplantation renal function in 86 children after PB as observational study. Patients were divided into 3 groups:Glomerular filtration rate (GFR) and delta GFR were determined. Read More

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http://dx.doi.org/10.1097/MD.0000000000020522DOI Listing

In-hospital Outcomes of Left Ventricular Assist Devices (LVAD) Patients Undergoing Noncardiac Surgery.

ASAIO J 2020 Jun 4. Epub 2020 Jun 4.

From the Division of Cardiovascular Diseases, Section of Heart Failure and Transplant, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

An increasing number of stage D heart failure patients are supported with left ventricular assist devices (LVADs), and the management of LVAD patients who require noncardiac surgery (NCS) presents unique challenges. Using the 2010-2014 National Inpatient Sample, we identified all adult cases of LVAD patients undergoing noncardiac surgeries using ICD-9-CM codes. We estimated inpatient mortality, bleeding complications, stroke, length of stay (LOS), and cost of hospitalization of the admissions related to NCS using mixed effects logistic and linear mixed regressions, respectively. Read More

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http://dx.doi.org/10.1097/MAT.0000000000001205DOI Listing

[i]Clostridioides difficile[/i] infection in patients with end stage renal disease. Is it preventable?

Przegl Epidemiol 2020 ;74(1):11-21

Research and Development Center, Provincial Specialist Hospital in Wroclaw, Poland.

[i]Clostridioides difficile[/i] infection (CDI) is a leading cause of a healthcare-associated diarrhea worldwide. Recently, an increased number of new cases and growing mortality due to CDI have been observed. Patients suffering from end-stage renal disease (ESRD) are most exposed to CDI. Read More

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http://dx.doi.org/10.32394/pe.74.02DOI Listing
January 2020

No evidence of a legacy effect on survival following randomization to extended hours dialysis in the ACTIVE Dialysis trial.

Nephrology (Carlton) 2020 Jun 5. Epub 2020 Jun 5.

The George Institute for Global Health and University of New South Wales, Sydney, Australia.

Aim: Extended hours hemodialysis is associated with superior survival to standard hours. However, residual confounding limits the interpretation of this observation. We aimed to determine the effect of a period of extended hours dialysis on long-term survival among participants in the ACTIVE Dialysis trial. Read More

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http://dx.doi.org/10.1111/nep.13737DOI Listing

Case series of six kidney transplanted patients with COVID-19 pneumonia treated with tocilizumab.

Transpl Infect Dis 2020 Jun 5:e13348. Epub 2020 Jun 5.

Renal Transplant Center "A. Vercellone", Nephrology, Dialysis and Renal Transplant Division, "Città della Salute e della Scienza" Hospital, Department of Medical Sciences, University of Turin, Turin, Italy.

Few reports described the outcome of kidney transplanted patients (KTs) affected by COVID-19 treated with interleukin-6 receptor inhibitor Tocilizumab (TCZ). We report our case series of 6 KTs with COVID-19 pneumonia who received TCZ: all were of male gender, with a mean age of 55.5±8. Read More

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http://dx.doi.org/10.1111/tid.13348DOI Listing

Failed antibody response in a renal transplant recipient with SARS-CoV-2 infected.

Transpl Infect Dis 2020 Jun 5:e13349. Epub 2020 Jun 5.

Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China, 430071.

In late December 2019, severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) has been identified as a novel pathogen causing Coronavirus Disease 2019 (COVID-19) in Wuhan, China, subsequently spread to the rest of China and has been demonstrating a rapid global spread. Nucleic acid testing (NAT, tested by real-time polymerase chain reaction) of SARS-CoV-2 virus in oropharyngeal/nasal swab samples has been described to be extremely sensitive for the diagnose of SARS-CoV-2 infection, but false-negative results have been reported. Recent months, researches demonstrated the importance of IgM/IgG antibody detecting due to the unsatisfied positive rate of NAT, and the increasement IgM/IgG antibody was considered as a confirmed criteria of diagnosis in the official guides of the diagnosis and treatment of COVID-19 in China (7 Edition) . Read More

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http://dx.doi.org/10.1111/tid.13349DOI Listing

Continuing our work: transplant surgery and surgical oncology in a tertiary referral COVID-19 center.

Updates Surg 2020 Jun 4. Epub 2020 Jun 4.

Department of General Surgery and Liver Transplantation Service, San Camillo Forlanini, Italian National Institute for the Infectious Diseases "L. Spallanzani", Via Giacomo Folchi 6A, Rome, Italy.

COVID-19 is rapidly spreading worldwide. Healthcare systems are struggling to properly allocate resources while ensuring cure for diseases outside of the infection. The aim of this study was to demonstrate how surgical activity was affected by the virus outbreak and show the changes in practice in a tertiary referral COVID-19 center. Read More

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http://dx.doi.org/10.1007/s13304-020-00825-3DOI Listing

Extracorporeal renal and liver support in pediatric acute liver failure.

Pediatr Nephrol 2020 Jun 5. Epub 2020 Jun 5.

Pediatric Intensive Care Unit, King's College Hospital, 3rd Floor Cheyne Wing, London, SE5 9RS, UK.

The liver is the only organ which can regenerate and, thus, potentially negate the need for transplantation in acute liver failure (ALF). Cerebral edema and sepsis are leading causes of mortality in ALF. Both water-soluble and protein-bound toxins have been implicated in pathogenesis of various ALF complications. Read More

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http://dx.doi.org/10.1007/s00467-020-04613-4DOI Listing

Radical Cystectomy and Ileal Conduit Diversion for Bladder Urothelial Carcinoma With Sarcomatoid and Squamous Variants After Renal Transplantation.

Cureus 2020 May 2;12(5):e7935. Epub 2020 May 2.

Urology, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, TUR.

Renal transplantation is the optimal treatment for patients with end-stage renal disease. However, the incidence of malignancies, especially urological malignancies, increases after renal transplantation due to long-term immunosuppressive treatments. We report a case of radical cystectomy and ileal conduit diversion in a 39-year-old female patient who developed invasive bladder carcinoma with extravesical extension three years after renal transplantation. Read More

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http://dx.doi.org/10.7759/cureus.7935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265775PMC

Effect of Hyperbaric Oxygen on Tissue Damage and Expression of Adhesion Molecules and C3 in a Rat Model of Renal Ischemia-Reperfusion Injury After Kidney Transplantation.

Ann Transplant 2020 Jun 5;25:e919385. Epub 2020 Jun 5.

Medical College of Soochow University, Suzhou, Jiangsu, China (mainland).

BACKGROUND The aim of this study was to investigate the protective effect and mechanism of hyperbaric oxygen (HBO) in a rat model of renal ischemia-reperfusion injury following kidney transplantation. MATERIAL AND METHODS Sprague Dawley rats were randomly divided into 3 groups (n=18): sham group, kidney transplantation group, and HBO treatment group. Six rats in each group were sacrificed at 1, 3, and 5 hours after reperfusion, and serum and renal tissue were then collected. Read More

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http://dx.doi.org/10.12659/AOT.919385DOI Listing

Striking a Balance in Simultaneous Heart Kidney Transplant: Optimizing Outcomes for All Wait-Listed Patients.

J Am Soc Nephrol 2020 Jun 4. Epub 2020 Jun 4.

Department of Surgery, Duke Transplant Center, Duke University, Durham, North Carolina

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http://dx.doi.org/10.1681/ASN.2020030336DOI Listing

GFR in Healthy Aging: an Individual Participant Data Meta-Analysis of Iohexol Clearance in European Population-Based Cohorts.

J Am Soc Nephrol 2020 Jun 4. Epub 2020 Jun 4.

Institute of Public Health, Charité - Berlin University of Medicine, Berlin, Germany.

Background: Population mean GFR is lower in older age, but it is unknown whether healthy aging is associated with preserved rather than lower GFR in some individuals.

Methods: We investigated the cross-sectional association between measured GFR, age, and health in persons aged 50-97 years in the general population through a meta-analysis of iohexol clearance measurements in three large European population-based cohorts. We defined a healthy person as having no major chronic disease or risk factors for CKD and all others as unhealthy. Read More

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http://dx.doi.org/10.1681/ASN.2020020151DOI Listing

Effects of Obesity on Postoperative Complications and Graft Survival After Kidney Transplantation.

Transplant Proc 2020 Jun 1. Epub 2020 Jun 1.

Service d'Urologie, Andrologie et Transplantation Rénale, CHU Besançon, France; Université de Franche-Comté, Besançon, France.

Objective: The objective of this study was to analyze the effects of obesity on postoperative complications and patient and graft survival after kidney transplantation.

Methods: We retrospectively included 506 patients who received a kidney transplant in our center during eleven years. Obesity was defined by a body mass index ≥ 30 kg/m based on World Health Organization criteria. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.02.178DOI Listing

Gene polymorphisms and risk of acute renal graft rejection: A field synopsis of meta-analyses and genome-wide association studies.

Transplant Rev (Orlando) 2020 Jul 11;34(3):100548. Epub 2020 May 11.

Department of Pharmaceutical Sciences and Interdepartmental Research Center of Pharmacogenetics and Pharmacogenomics (CRIFF), University of Piemonte Orientale, Largo Donegani 2, Novara 28100, Italy. Electronic address:

In the present study we systematically re-analyzed results from meta-analyses and genome-wide association studies (GWASs) to assess the credibility of genetic associations with acute rejection risk in renal transplantation. A comprehensive literature search was performed on PubMed, Web of Knowledge, Cochrane library, and Open Grey up to July 2019. Methodological quality of systematic meta-analyses was assessed by the AMSTAR tool. Read More

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http://dx.doi.org/10.1016/j.trre.2020.100548DOI Listing

Acute Kidney Injury: From Diagnosis to Prevention and Treatment Strategies.

J Clin Med 2020 Jun 2;9(6). Epub 2020 Jun 2.

Department of Medicine, Division of Nephrology and Renal Transplantation, Centro Hospitalar Lisboa Norte, EPE, Av. Prof. Egas Moniz, 1649-035 Lisboa, Portugal.

Acute kidney injury (AKI) is characterized by an acute decrease in renal function that can be multifactorial in its origin and is associated with complex pathophysiological mechanisms. In the short term, AKI is associated with an increased length of hospital stay, health care costs, and in-hospital mortality, and its impact extends into the long term, with AKI being associated with increased risks of cardiovascular events, progression to chronic kidney disease (CKD), and long-term mortality. Given the impact of the prognosis of AKI, it is important to recognize at-risk patients and improve preventive, diagnostic, and therapy strategies. Read More

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http://dx.doi.org/10.3390/jcm9061704DOI Listing

Acute kidney injury and chronic kidney disease after non-kidney solid organ transplantation.

Pediatr Transplant 2020 Jun 4:e13753. Epub 2020 Jun 4.

Division of Nephrology, Seattle Children's Hospital, Seattle, WA, USA.

Background: SOT is the treatment of choice for end-stage organ disease. Improved long-term survival after NKSOT has uncovered chronic morbidity including CKD. AKI is common after NKSOT and may be associated with long-term CKD. Read More

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http://dx.doi.org/10.1111/petr.13753DOI Listing

[Therapeutic innovation in nephrology : 10 years of progress].

Rev Med Liege 2020 May;75(5-6):336-343

Service de Néphrologie-Dialyse-Transplantation, CHU Liège, Belgique.

Chronic kidney disease (CKD) impairs the quality of life and increases the risk for cardiovascular morbimortality. Intensive research is conducted in order to slow down CKD development and progression. During the past decade, a better understanding of the pathophysiological mechanisms of glomerular diseases has highlighted the benefits of rituximab. Read More

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A Propensity Score-weighted Comparison of Outcomes Between Living and Standard Criteria Deceased Donor Kidney Transplant Recipients.

Transplantation 2020 Jun 1. Epub 2020 Jun 1.

ICES, London, Ontario, Canada.

Background: Consider a theoretical situation in which 2 patients with similar baseline characteristics receive a kidney transplant on the same day: 1 from a standard criteria deceased donor, the other from a living donor. Which kidney transplant will last longer?

Methods: We conducted a population-based cohort study using linked administrative healthcare databases from Ontario, Canada from January 1, 2005 to March 31, 2014 to evaluate several posttransplant outcomes in individuals who received a kidney transplant from a standard criteria deceased donor (n=1523) or from a living donor (n=1373). We used propensity-score weighting using overlap weights, a novel weighting method that emphasizes the population of recipients with the most overlap in baseline characteristics. Read More

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http://dx.doi.org/10.1097/TP.0000000000003337DOI Listing

Early Experience With COVID-19 and Solid Organ Transplantation at a US High-volume Transplant Center.

Transplantation 2020 Jun 1. Epub 2020 Jun 1.

Department of Surgery, Houston Methodist Hospital, Houston, TX 77030.

Background: The novel coronavirus SARS-CoV-2 (COVID-19) poses unique challenges for immunosuppressed patients. Solid organ transplant recipients (SOT) comprise a large proportion of this group, yet there is limited knowledge about the presentation, clinical course and immunosuppression management of this novel infection among heart, lung, liver, pancreas and kidney transplant recipients.

Methods: We present 21 SOT diagnosed with COVID-19 between January 1, 2020 - April 22, 2020 at a US high-volume transplant center. Read More

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http://dx.doi.org/10.1097/TP.0000000000003339DOI Listing

Inosine 5'-Monophosphate Dehydrogenase Activity for the Longitudinal Monitoring of Mycophenolic Acid Treatment in Kidney Allograft Recipients.

Transplantation 2020 Jun 1. Epub 2020 Jun 1.

Department of Nephrology and Internal Intensive Care Medicine, Campus Charité Mitte, Charité - Universitätsmedizin Berlin.

Background: Mycophenolic acid (MPA) is a standard immunosuppressant in organ transplantation. A simple monitoring biomarker for MPA treatment has not been established so far. Here, we describe inosine 5'-monophosphate dehydrogenase (IMPDH) monitoring in erythrocytes and its application to kidney allograft recipients. Read More

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http://dx.doi.org/10.1097/TP.0000000000003336DOI Listing

Real-world treatment patterns and outcomes using terlipressin in 203 patients with the hepatorenal syndrome.

Aliment Pharmacol Ther 2020 Jun 4. Epub 2020 Jun 4.

Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

Background: Hepatorenal syndrome and acute kidney injury are common complications of decompensated cirrhosis, and terlipressin is recommended as first-line vasoconstrictor therapy. However, data on its use outside of clinical trials are lacking.

Aims: To assess practice patterns and outcomes around vasoconstrictor use for hepatorenal syndrome in UK hospitals. Read More

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http://dx.doi.org/10.1111/apt.15836DOI Listing

Imbalance favoring follicular helper T cells over IL10 regulatory B cells is detrimental for the kidney allograft.

Kidney Int 2020 Apr 20. Epub 2020 Apr 20.

Department of Immunology, Hospital 12 de Octubre, Madrid, Spain; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain; Department of Immunology, Universidad Complutense de Madrid, Madrid, Spain.

A high frequency of regulatory B (Breg) cells, generally transitional B cells, has been associated with long-term kidney allograft survival and operational tolerance. However, circulating follicular helper T cells (cTfh) correlate with graft rejection. In order to better understand the interplay between these cell subsets and to determine their association with graft outcome we studied transitional and IL10 Breg cells, as well as cTfh, pre- and post-transplantation in a prospective cohort of 200 kidney transplant recipients and in healthy volunteers,. Read More

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http://dx.doi.org/10.1016/j.kint.2020.02.039DOI Listing

Impact of the intensity of intermittent renal replacement therapy in critically ill patients.

J Nephrol 2020 Jun 3. Epub 2020 Jun 3.

Nephrology and Kidney Transplantation Department, Hospital Clínic, IDIBAPS, University of Barcelona, Barcelona, Spain.

Background: Intermittent renal replacement therapy (IRRT) is prescribed across intensive care units (ICU) worldwide. While research regarding the prescribed dialysis dose has not yielded results concerning mortality, it is still unknown whether the same applies to the actual delivered dose.

Methods: We retrospectively analyzed two different cohorts of patients (562 IRRT sessions) who were admitted to the intensive care units at Hospital Clínic of Barcelona and required renal replacement therapy with IRRT. Read More

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http://dx.doi.org/10.1007/s40620-020-00760-xDOI Listing

COVID-19 and kidney transplantation: an Italian Survey and Consensus.

J Nephrol 2020 Jun 3. Epub 2020 Jun 3.

Division of General and Transplant Surgery, University of Pisa, Pisa, Italy.

Italy was the first Western country to face the COVID-19 pandemic. Here we report the results of a national survey on kidney transplantation activity in February and March 2020, and the results of a three-round Delphi consensus promoted by four scientific societies: the Italian Society of Organ Transplantation, the Italian Society of Nephrology, the Italian Society of Anesthesia and Intensive Care, and the Italian Group on Antimicrobial Stewardship. All 41 Italian transplant centers were invited to express their opinion in the Delphi rounds along with a group of seven experts. Read More

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http://dx.doi.org/10.1007/s40620-020-00755-8DOI Listing

Pelvic radiation therapy with volumetric modulated arc therapy and intensity-modulated radiotherapy after renal transplant: A report of 3 cases.

Rep Pract Oncol Radiother 2020 Jul-Aug;25(4):548-555. Epub 2020 Apr 28.

Radiotherapy and Medical Physics Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. 15 Vasco de Quiroga, Belisario Domínguez, Sección XVI, Tlalpan, Mexico City, 14080, Mexico.

Aim: Describe characteristics and outcomes of three patients treated with pelvic radiation therapy after kidney transplant.

Background: The incidence of pelvic cancers in kidney transplant (KT) recipients is rising. Currently it is the leading cause of death. Read More

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http://dx.doi.org/10.1016/j.rpor.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256055PMC

Determinants of Successful Use of Sirolimus in Renal Transplant Patients.

Transplant Proc 2020 May 31. Epub 2020 May 31.

Division of Nephrology, Hannover Medical School, Hannover, Germany.

Background: Sirolimus is an established immunosuppressant in renal transplantation with antineoplastic and antiviral features, but side effects like proteinuria limit its use. The aim of this retrospective multicenter observational study is to define predictors for determining which patients most likely benefit from a sirolimus-based therapy.

Methods: All patients from 10 German centers that were switched to a sirolimus-containing maintenance immunosuppression in 2000 to 2008 after 3 months or later post-transplantation were enrolled (n = 726). Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.02.159DOI Listing

Long-term outcomes of adult-size and size-matched kidney transplants in small pediatric recipients.

J Pediatr Urol 2020 May 20. Epub 2020 May 20.

Department of Pediatric Urology, Hospital Universitario La Paz, Paseo de La Castellana 261, 28046, Madrid, Spain.

Introduction: Adult-size kidneys are usually used for kidney transplantation in small pediatric recipients, but the influence of graft size in transplant outcome remains controversial. Our aim is to compare long-term transplant outcomes of using adult-size and size-matched kidneys in small pediatric recipients.

Materials And Methods: Since 1999, 61 of 226 kidney transplants were achieved in recipients weighing <20 kg with 5 years of follow-up. Read More

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http://dx.doi.org/10.1016/j.jpurol.2020.05.012DOI Listing

Quality of life among patients with multiple sclerosis and voiding dysfunction: a cross-sectional study.

BMC Urol 2020 Jun 3;20(1):62. Epub 2020 Jun 3.

Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Evaluating the usefulness of treatment requires a direct measurement of the health-related quality of life (QOL). Therefore, this study was carried out aiming to determine the QOL of patients with MS and voiding dysfunction.

Methods: This cross-sectional study was carried out using multi-stage random cluster sampling method on 602 patients with MS in Isfahan, Iran. Read More

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http://dx.doi.org/10.1186/s12894-020-00590-wDOI Listing

Liver Cirrhosis Complications Management At The Emergency Department.

Rev Recent Clin Trials 2020 Jun 3. Epub 2020 Jun 3.

Department of Health Sciences, University "Magna Græcia", Catanzaro. Italy.

Background And Aims: liver cirrhosis (LC) of any origin has always been a source of several emergencies for physicians working at the Emergency Department (ER). LC patients can present with several complications that are sometimes difficult to recognize and treat. Thus, we reviewed the literature evidences for the diagnosis and management of several LC related emergencies. Read More

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http://dx.doi.org/10.2174/1574887115666200603160816DOI Listing

Conversion from Standard-Release Tacrolimus to MeltDose Tacrolimus (LCPT) Improves Renal Function after Liver Transplantation.

J Clin Med 2020 Jun 1;9(6). Epub 2020 Jun 1.

Department of Medicine B, Gastroenterology and Hepatology, University Hospital Münster, 48149 Münster, Germany.

Renal impairment is a typical side effect of tacrolimus (Tac) treatment in liver transplant (LT) recipients. One strategy to avoid renal dysfunction is to increase the concentration/dose (C/D) ratio by improving drug bioavailability. LT recipients converted from standard-release Tac to MeltDose Tac (LCPT), a novel technological formulation, were able to reduce the required Tac dose due to higher bioavailability. Read More

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http://dx.doi.org/10.3390/jcm9061654DOI Listing

Anti-hla donor specific antibody monitoring in pancreas transplantation: role of protocol biopsies.

Clin Transplant 2020 Jun 3:e13998. Epub 2020 Jun 3.

Kidney Pancreas Transplantation, Instituto de Trasplantes y Alta Complejidad (ITAC - Nephrology), Buenos Aires, Argentina.

In kidney transplantation de novo donor-specific antibodies (DSA) correlate with poor graft survival, and Consensus Guidelines recommend a protocol biopsy. In pancreas transplantation DSA are also associated with poor graft outcomes; however, there are no recommendations on protocol biopsies. We started an antibody screening protocol on pancreas transplant patients at 0, 3, 6, 12 months and yearly. Read More

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http://dx.doi.org/10.1111/ctr.13998DOI Listing

New insights into risk factors for transplant-associated thrombotic microangiopathy in pediatric HSCT.

Blood Adv 2020 Jun;4(11):2418-2429

Department of Blood and Marrow Transplantation, Great Ormond Street (GOS) Hospital for Children NHS Foundation Trust, University College London GOS Institute of Child Health, and NIHR GOSH BRC, London, United Kingdom.

This study aimed to identify a risk profile for development of transplant-associated thrombotic microangiopathy (TA-TMA) in children undergoing hematopoietic stem cell transplantation (HSCT). Between 2013 and 2016, 439 children underwent 474 HSCTs at 2 supraregional United Kingdom centers. At a median of 153 days post-HSCT, TA-TMA occurred among 25 of 441 evaluable cases (5. Read More

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http://dx.doi.org/10.1182/bloodadvances.2019001315DOI Listing

Kidney Transplantation from HBsAg+ Living Donors to HBsAg- Recipients: Benefits and Risks.

Clin Infect Dis 2020 Jun 3. Epub 2020 Jun 3.

Translational Research in Inflammation and Immunology Research Unit (TRIRU), Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

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http://dx.doi.org/10.1093/cid/ciaa707DOI Listing

Crossing borders to facilitate live donor kidney transplantation: the Czech-Austrian kidney paired donation program.

Transpl Int 2020 Jun 3. Epub 2020 Jun 3.

Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.

Kidney paired donation (KPD) is a valuable tool to overcome immunological barriers in living donor transplantation. While small national registries encounter difficulties in finding compatible matches, multi-national KPD may be a useful strategy to facilitate transplantation. The Czech (Prague) and Austrian (Vienna) KPD programs, both initiated in 2011, were merged in 2015. Read More

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http://dx.doi.org/10.1111/tri.13668DOI Listing

Vismodegib Experience in a Renal Transplant Patient With Basal Cell Carcinoma.

Exp Clin Transplant 2020 06 2. Epub 2020 Jun 2.

From the Medical Oncology Department and the 2Transplantation Department, Baskent University, Ankara, Turkey.

The hedgehog inhibitor vismodegib has been tested and suggested as an effective treatment option for cases of locally advanced or metastatic basal cell carcinoma. A 58-year-old female renal transplant patient with recurrent, inoperable basal-cell carcinoma that originated from nasal skin was evaluated by the transplantation counsel. After a multidisciplinary evaluation of the patient, vismodegib at a dose of 150 mg/day was started in February 2018. Read More

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http://dx.doi.org/10.6002/ect.2020.0293DOI Listing

Essential updates 2018/2019: Liver transplantation.

Ann Gastroenterol Surg 2020 May 25;4(3):195-207. Epub 2020 Feb 25.

Department of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan.

Among the recent topics in the field of liver transplantation (LT), one of the significant therapeutic breakthroughs is the introduction of direct-acting antiviral agents (DAAs) against hepatitis C virus (HCV) infection. With cure rates close to 100%, a better proportion of LT candidates and recipients can be cured of HCV infection by DAA therapies that are simple and well-tolerated. Other critical topics include the issue of indication of LT for patients with hepatocellular carcinoma, which has been continuously studied. Read More

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http://dx.doi.org/10.1002/ags3.12321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240140PMC

PD-L1 pathway as a novel target in carcinosarcoma of the kidney and renal pelvis.

Urol Case Rep 2020 Nov 23;33:101261. Epub 2020 May 23.

RoMIUS Institute of Northwest Ohio, Toledo, OH, United States.

Carcinosarcoma of the kidney and renal pelvis (CSKP) is a rare and highly-aggressive malignancy characterized by rapid progression and widespread metastases. To date, few studies describe the natural history of the disease. We present a patient placed on pembrolizumab therapy for suspected metastatic colon cancer. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260670PMC
November 2020

Page kidney phenomenon in kidney allograft following abdominal trauma.

Urol Case Rep 2020 Sep 23;32:101274. Epub 2020 May 23.

University of Utah School of Medicine, Department of Surgery, Division of Transplantation and Advanced Hepatobiliary Surgery, USA.

The page kidney phenomenon is often associated in patients with abdominal trauma. External compression from a renal hematoma can cause hypertension, and presentation can be delayed following the initial injury. For patients who have a kidney allograft, page kidneys may lead to renal insufficiency and acute renal failure due to the absence of a contralateral kidney to compensate. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260421PMC
September 2020

: an underlying immunosuppression? Clinical manifestations, pathogenesis, diagnostic examinations and treatment.

Postepy Dermatol Alergol 2020 Apr 5;37(2):154-158. Epub 2020 May 5.

Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland.

Due to constantly growing population of immunocompromised patients the fungi became a widespread threat to modern medicine. HIV carriers, solid organ transplant recipients constitute most of those patients. Cryptococcosis is a frequent cause of life-threatening infections, affecting mostly immunosuppressed patients. Read More

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http://dx.doi.org/10.5114/ada.2020.94833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262803PMC

Hyperferritinemia and acute kidney injury in pediatric patients receiving allogeneic hematopoietic cell transplantation.

Pediatr Nephrol 2020 Jun 2. Epub 2020 Jun 2.

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: Acute kidney injury (AKI) often occurs in pediatric patients who received allogeneic hematopoietic cell transplantation (HCT). We evaluated the risk and effect of HCT-related AKI in pediatric patients.

Methods: We retrospectively studied the survival and renal outcome of 69 children 100 days and 1-year posttransplant in our institution in 2004-2016. Read More

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http://dx.doi.org/10.1007/s00467-020-04619-yDOI Listing

Cervical cancer screening abnormalities in immunosuppressed renal transplant women: case-control study in Southern Brazil.

Arch Gynecol Obstet 2020 Jun 1. Epub 2020 Jun 1.

Graduate Program in Health Sciences: Gynecology and Obstetrics, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil.

Purpose: To evaluate the prevalence of cervical pre-malignancies in the cervical cytology of female renal transplant recipients (RTR) and compare to immunocompetent patients.

Methods: A prospective case-control study of 165 RTR (cases) and 372 immunocompetent women (controls) was carried out from May 2015 to August 2016. The participants completed a questionnaire with demographic characteristics, habits, reproductive history, and information about the renal transplant. Read More

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http://dx.doi.org/10.1007/s00404-020-05621-3DOI Listing

Heme-Oxygenase and Kidney Transplantation: A Potential for Target Therapy?

Biomolecules 2020 May 30;10(6). Epub 2020 May 30.

Organ Transplant Unit, University Hospital of Catania, 95123 Catania, Italy.

Kidney transplantation is a well-established therapy for patients with end-stage renal disease. While a significant improvement of short-term results has been achieved in the short-term, similar results were not reported in the long-term. Heme-oxygenase (HO) is the rate-limiting enzyme in heme catabolism, converting heme to iron, carbon monoxide, and biliverdin. Read More

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http://dx.doi.org/10.3390/biom10060840DOI Listing

Associations between Proton Pump Inhibitor and Histamine-2 Receptor Antagonist and Bone Mineral Density among Kidney Transplant Recipients.

Am J Nephrol 2020 Jun 2:1-9. Epub 2020 Jun 2.

Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA,

Background: In the general population, use of proton pump inhibitor (PPI) has been linked to higher risk of osteoporotic fractures. PPI is commonly prescribed in kidney transplant recipients (KTRs). However, the effect of PPI on osteoporosis in KTRs is largely unstudied. Read More

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http://dx.doi.org/10.1159/000507470DOI Listing

Five decades with grandparent donors: The Norwegian strategy and experience.

Pediatr Transplant 2020 Jun 2:e13751. Epub 2020 Jun 2.

Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Living donors (LDs) are preferred over DDs for renal transplantation in children due to superior GS. Oslo University Hospital has never restricted living donation by upper age. The aim of this study was to investigate long-term outcomes using grandparents (GPLD) compared to PLD. Read More

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http://dx.doi.org/10.1111/petr.13751DOI Listing

Renal Function Parameters and Serum Sodium Enhance Prediction of Waitlist Outcomes in Pediatric Liver Transplantation.

Hepatology 2020 Jun 2. Epub 2020 Jun 2.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.

Reliance upon exception points to prioritize children for liver transplantation (LT) stems from concerns that the Pediatric End-Stage Liver Disease (PELD) score underestimates mortality. Renal dysfunction and serum sodium disturbances are negative prognosticators in adult LT candidates and various pediatric populations, but are not accounted for in PELD. We retrospectively evaluated the impact of these parameters in predicting 90-day waitlist death/deterioration amongst pediatric patients (<12-years) listed for isolated LT in the United States between Feb 2002-June 2018. Read More

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http://dx.doi.org/10.1002/hep.31397DOI Listing

A short overview on mycophenolic acid pharmacology and pharmacokinetics.

Clin Transplant 2020 Jun 2:e13997. Epub 2020 Jun 2.

Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Av. Ipiranga 2752, 90610-000, Porto Alegre - RS, Brazil.

Immunosuppressive therapy is used in solid organ transplant treatment, and mycophenolic acid (MPA) is one of the immunosuppressive drugs most used worldwide. It is a potent, selective, non-competitive, and reversible inosine monophosphate dehydrogenase (IMPDH) inhibitor that acts to inhibit guanine synthesis. To improve solubility, MPA is used as the prodrug mycophenolate mofetil (MMF) or as an enteric-coated mycophenolate sodium salt (EC-MPS). Read More

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http://dx.doi.org/10.1111/ctr.13997DOI Listing