136,597 results match your criteria Renal Transplantation


[Résumé : Les candidats à une transplantation rénale doivent faire l'objet d'une évaluation complète, y compris urologique. Ce bilan urologique permet, tout d'abord, d'exclure toute pathologie de l'arbre urinaire susceptible de contre-indiquer une greffe r].

Rev Med Liege 2019 Mar;74(3):152-158

Service d'Urologie, CHU Liège, Belgique.

Candidates for a kidney transplantation must undergo a complete evaluation, including a urological evaluation. This urological assessment should first of all exclude any pathology of the urinary tract likely to contraindicate a transplantation or to evolve under immunosuppression. Moreover, this assessment should evaluate the lower urinary tract that is to receive a kidney graft. Read More

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Prevalence of high-risk HPV and atypia in liquid-based cytology of cervical and intra-anal specimens from kidney-transplanted women.

Diagn Cytopathol 2019 Mar 21. Epub 2019 Mar 21.

Gynecology and Obstetrics Department, State University of Campinas, Campinas, Brazil.

Background: There is a high frequency of human papillomavirus (HPV)-induced lesions in cervix and anus of immunosuppressed patients. However, few studies have evaluated these lesions in kidney-transplanted women.

Methods: This cross-sectional study examined 31 kidney-transplanted women receiving immunosuppressive therapy at the General Hospital of Fortaleza in Brazil. Read More

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http://dx.doi.org/10.1002/dc.24180DOI Listing

Prophylactic onlay reinforcement with absorbable mesh (polyglactin) is associated with less early wound complications after kidney transplantation: A preliminary study.

J Biomed Mater Res B Appl Biomater 2019 Mar 21. Epub 2019 Mar 21.

Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

Incidence of wound complications after kidney transplantation (KTx) is still considerable. Here, we report the impact of prophylactic absorbable polyglactin (Vicryl®) mesh reinforcement on the incidence of short-term post-KTx wound complications. Sixty-nine patients were analyzed; 23 with and 46 without preventive onlay mesh reinforcement. Read More

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http://dx.doi.org/10.1002/jbm.b.34366DOI Listing
March 2019
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Refractory ascites and graft dysfunction in early renal transplantation.

J Bras Nefrol 2019 Mar 18. Epub 2019 Mar 18.

Serviço de Nefrologia e Transplantação Renal do Centro Hospitalar do Porto, Porto, Portugal.

The occurrence of ascites after Renal Transplant (RT) is infrequent, and may be a consequence of surgical or medical complications. Case report: 61 year-old, male, history of arterial hypertension, tongue carcinoma and alcoholic habits 12-20g/day. He had chronic kidney disease secondary to autosomal dominant polycystic kidney disease, without hepatic polycystic disease. Read More

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http://dx.doi.org/10.1590/2175-8239-JBN-2018-0175DOI Listing

Cyclosporine A trough concentrations are associated with acute GvHD after non-myeloablative allogeneic hematopoietic cell transplantation.

PLoS One 2019 21;14(3):e0213913. Epub 2019 Mar 21.

Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.

Low plasma CsA concentrations (<300-350 ng/mL) early following allogeneic hematopoietic stem cell transplantation (HSCT) is associated with an increased risk of developing acute graft-versus-host disease (aGvHD). Nevertheless, the current optimal target trough concentration for CsA following HSCT is considered to be 200-400 ng/mL. Here, we performed a retrospective analysis of a homogeneous group of 129 patients who received HSCT after non-myeloablative conditioning, and we analyzed the impact of CsA trough concentration measured during the first four weeks (CsA W1-4) on the incidence aGvHD, relapse-free survival (RFS), non-relapse mortality (NRM), overall survival (OS), and toxicity. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213913PLOS

SDF‑1/CXCR4 induces epithelial‑mesenchymal transition through activation of the Wnt/β‑catenin signaling pathway in rat chronic allograft nephropathy.

Mol Med Rep 2019 Mar 15. Epub 2019 Mar 15.

Urology Institute of Capital Medical University, Department of Urology, Capital Medical University Beijing Chaoyang Hospital, Beijing 100020, P.R. China.

Epithelial‑mesenchymal transition (EMT) has been demonstrated to serve a crucial role in the progression of interstitial fibrosis, which is one of the principal pathological features of chronic allograft nephropathy (CAN). However, to the best of our knowledge, the mechanisms of EMT in CAN have not been investigated. In the present study, the effect of stromal cell‑derived factor 1 (SDF‑1) and the Wnt signaling pathway on the progression of EMT following kidney transplantation was investigated. Read More

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http://dx.doi.org/10.3892/mmr.2019.10045DOI Listing
March 2019
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A multicenter application of the 2018 Banff Classification for BK polyomavirus-associated nephropathy in renal transplantation.

Transplantation 2019 Mar 21. Epub 2019 Mar 21.

Amsterdam UMC, University of Amsterdam, Department of Pathology, Amsterdam Infection & Immunity Institute (AI&II), Amsterdam Cardiovascular Sciences (ACS), Meibergdreef 9, Amsterdam, The Netherlands.

Background: With current immunosuppressive regimens, BK polyomavirus associated nephropathy (BKPyVAN) is still a matter of concern. Stratification of patients at risk for allograft loss is of uttermost importance to guide treatment choice and assess prognosis. In 2018, the Banff working group proposed a classification scheme for the prognosis of BKPyVAN, but external application on independent cohorts has yet to be performed. Read More

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http://dx.doi.org/10.1097/TP.0000000000002712DOI Listing

Sero Conversion of Viral Hepatitis among End Stage Renal Disease Patients on Hemodialysis in Kashmir: Results of a Prospective Study.

Open Access Maced J Med Sci 2019 Feb 26;7(4):587-593. Epub 2019 Feb 26.

Department of Nephrology, SKIMS, Srinagar, Kashmir.

Background: The seroconversion is a significant health concern in patients with end-stage renal disease undergoing hemodialysis particularly in high endemic zones of HBV and HCV.

Patients And Methods: This prospective study was conducted from January 2009 to April 2018 at Sheri Kashmir Institute of Medical Sciences, Srinagar, Kashmir. A cohort of 459 end-stage renal disease patients on hemodialysis was enrolled from four dialysis centres and followed in a longitudinal manner. Read More

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http://dx.doi.org/10.3889/oamjms.2019.160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420930PMC
February 2019

Global Variation of Nutritional Status in Children Undergoing Chronic Peritoneal Dialysis: A Longitudinal Study of the International Pediatric Peritoneal Dialysis Network.

Sci Rep 2019 Mar 20;9(1):4886. Epub 2019 Mar 20.

Children's Mercy Hospital, Kansas City, MO, USA.

While children approaching end-stage kidney disease (ESKD) are considered at risk of uremic anorexia and underweight they are also exposed to the global obesity epidemic. We sought to investigate the variation of nutritional status in children undergoing chronic peritoneal dialysis (CPD) around the globe. The distribution and course of body mass index (BMI) standard deviation score over time was examined prospectively in 1001 children and adolescents from 35 countries starting CPD who were followed in the International Pediatric PD Network (IPPN) Registry. Read More

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http://dx.doi.org/10.1038/s41598-018-36975-zDOI Listing

Positive Immuno-Modulation Following Radiofrequency Assisted Liver Resection in Hepatocellular Carcinoma.

J Clin Med 2019 Mar 19;8(3). Epub 2019 Mar 19.

Department of Surgery and Cancer, Imperial College London, London, SW7 2AZ, UK.

Introduction: Hepatocellular carcinoma (HCC) often develops on a background of chronic inflammation and a complex immunosuppressive network with increased regulatory T cells, impaired CD8⁺ T cells and the secretion of immunosuppressive cytokines. Previous clinical studies have reported a superior disease-free survival (DFS) following a radiofrequency-based ablation or resection in HCC tumours compared to conventional liver resection techniques. The aim of this study was to investigate whether there is any correlation with the use of a radiofrequency-assisted liver resection and clinical outcome. Read More

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http://dx.doi.org/10.3390/jcm8030385DOI Listing

S1Everolimus Initiation With Early Calcineurin Inhibitor Withdrawal in De Novo Heart Transplant Recipients: Long-term Follow-up From the Randomized SCHEDULE Study.

Transplantation 2019 Mar 12. Epub 2019 Mar 12.

Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway.

Background: A calcineurin inhibitor free immunosuppressive regimen has been demonstrated to improve renal function early after heart transplantation, but long-term outcome of such a strategy has not been well described.

Methods: In the randomized SCHEDULE trial, de novo heart transplant recipients received (1) everolimus with reduced-exposure calcineurin inhibitor (CNI, cyclosporine) followed by CNI withdrawal at weeks 7-11 post-transplant or (2) standard-exposure cyclosporine, both with mycophenolate mofetil and corticosteroids; 95/115 randomized patients were followed up at 5-7 years post-transplant.

Results: Mean measured GFR was 74. Read More

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http://dx.doi.org/10.1097/TP.0000000000002702DOI Listing
March 2019
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Small Split Pediatric Kidneys to Expand the Donor Pool: An analysis of Scientific Registry of Transplant Recipients (SRTR) Data.

Transplantation 2019 Mar 12. Epub 2019 Mar 12.

Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.

Background: Increased use of pediatric deceased donor kidneys could enlarge the deceased donor kidney pool. Kidney transplant outcomes from small pediatric donors were compared with those from ideal kidney (IK) and expanded criteria kidney (ECK) donors to understand the optimal use of pediatric donor kidneys.

Methods: Kaplan-Meier analyses compared long term patient and death censored graft survival of en-bloc kidney (EBK) and split kidney (SpK) transplants from small pediatric donors (age ≤8 years and <30 kg ) with those from IK and ECK. Read More

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http://dx.doi.org/10.1097/TP.0000000000002706DOI Listing
March 2019
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Successful ceftazidime-avibactam treatment of post-surgery Burkholderia multivorans genomovar II bacteremia and brain abscesses in a young lung transplanted woman with cystic fibrosis.

Transpl Infect Dis 2019 Mar 20:e13082. Epub 2019 Mar 20.

Cystic Fibrosis Center, IRCCS Ca' Granda Foundation Milan, Italy.

Burkholderia cepacia complex (Bcc) includes several phenotypically similar but genotypically distinct gram-negative bacteria (GNB) that can colonize the respiratory tract of Cystic Fibrosis (CF) patients. Pathogens are difficult to treat due to intrinsic resistance to multiple antibiotics and are associated to a more rapid decline in lung function and to increased mortality, particularly after lung transplantation. For all these reasons chronic infection by Burkholderia (B) cenocepacia is presently considered a relative or absolute contraindication in almost all lung transplant centres. Read More

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http://dx.doi.org/10.1111/tid.13082DOI Listing

A case of Pneumocystis pneumonia, with a granulomatous response and Vitamin D-mediated hypercalcemia, presenting 13 years after renal transplantation.

Transpl Infect Dis 2019 Mar 20:e13081. Epub 2019 Mar 20.

Department of Internal Medicine, Division of Infectious Disease, University of Wisconsin, School of Medicine and Public Health, Madison, WI, USA.

Vitamin D-mediated hypercalcemia is an uncommon complication of Pneumocystis infection. A granulomatous response resulting from Pneumocystis infection is also atypical. In this report, we describe an exceptional case of granulomatous Pneumocystis pneumonia associated with vitamin D-mediated hypercalcemia, in a patient who presented unusually late after renal transplantation. Read More

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http://dx.doi.org/10.1111/tid.13081DOI Listing

Evaluation of Clinical and Safety Outcomes Following Uncontrolled Tacrolimus Conversion in Adult Transplant Recipients.

Pharmacotherapy 2019 Mar 20. Epub 2019 Mar 20.

Department of Internal Medicine, Division of Nephrology and Hypertension, University of Cincinnati, Cincinnati, OH.

Purpose: To compare clinical and safety outcomes of transplant recipients converted between different tacrolimus formulations to those patients who remained on a single formulation in an outpatient environment.

Methodology: This was a single-center, retrospective cohort study at a large tertiary care medical center with an associated institutional outpatient pharmacy system. Adult transplant recipients with institutional pharmacy refill data from 08/01/2009 to 05/31/2016 were assessed. Read More

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http://dx.doi.org/10.1002/phar.2260DOI Listing

Surgical treatment of post-transplant encapsulating peritoneal sclerosis: A single-center experience.

Ulus Travma Acil Cerrahi Derg 2019 Mar;25(2):142-146

Department of General Surgery, İstanbul University İstanbul Faculty of Medicine, İstanbul-Turkey.

Background: Encapsulating peritoneal sclerosis (EPS) related to peritoneal dialysis (PD) has a vague etiology and high mortality. In this study, our aim was to determine treatment options for EPS cases.

Methods: A total of 169 patients underwent kidney transplantation from January 2008 to January 2018 and 119 patients from a cadaveric and 50 patients from a living donor. Read More

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http://dx.doi.org/10.14744/tjtes.2019.04838DOI Listing

Secondary Lymphoid Tissue and Costimulation-Blockade Resistant Rejection: A Nonhuman Primate Renal Transplant Study.

Am J Transplant 2019 Mar 20. Epub 2019 Mar 20.

Department of Surgery, Duke University Medical Center, Durham, North Carolina.

Naïve T cell activation requires antigen presentation combined with costimulation through CD28, both of which optimally occur in secondary lymphoid tissues such as lymph nodes and the spleen. Belatacept impairs CD28 costimulation by binding its ligands, CD80 and CD86, and in doing so, impairs de novo alloimmune responses. However, in most patients belatacept is ineffective in preventing allograft rejection when used as a monotherapy, and adjuvant therapy is required for control of costimulation-blockade resistant rejection (CoBRR). Read More

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http://dx.doi.org/10.1111/ajt.15365DOI Listing

Clinical features and outcomes of kidney transplant recipients with focal segmental glomerulosclerosis recurrence (FSGSr).

Nephrology (Carlton) 2019 Mar 19. Epub 2019 Mar 19.

Nephrology Division, Hospital do Rim, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.

Aim: FSGS recurs in up to 30% and up to 80% of adult and pediatric kidney transplant recipients, respectively. There is no standard of care treatment. The purpose of this study was to evaluate clinical characteristics, treatments and outcomes of patients with FSGSr. Read More

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http://dx.doi.org/10.1111/nep.13589DOI Listing

Pushing the envelope for obese kidney donor candidates.

Transpl Int 2019 Mar 19. Epub 2019 Mar 19.

University of Michigan, Section of Transplant Surgery.

Obesity has become a landmark issue in the field of transplantation. In 2013, kidney donors with a body mass index (BMI) greater than thirty represented 25% of all living kidney donors in the United States. This stands in stark contrast to the 1970's, when 8% of donors had a BMI above thirty(1). Read More

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http://dx.doi.org/10.1111/tri.13427DOI Listing

Late Cytomegalovirus Infection in Kidney Transplant Recipients after a Six-Month Prevention Protocol.

Int J Organ Transplant Med 2019 1;10(1):1-12. Epub 2010 Feb 1.

Renal Transplantation Department, Hospital de Santa Cruz, Lisboa, Portugal.

Background: Despite a reduction in the incidence of cytomegalovirus (CMV) infections after kidney transplantation, less is known about late CMV infection in kidney transplant recipients.

Objective: To assess incidence of CMV infection in a cohort of patients under a high surveillance CMV prevention protocol and identify factors associated with late CMV infection.

Methods: Analysis of a consecutive cohort of 181 kidney allograft recipients between January 2012 and Aug 2015. Read More

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February 2010

Successful pregnancy in a recipient of an ABO-incompatible renal allograft.

Obstet Med 2019 Mar 7;12(1):42-44. Epub 2018 Mar 7.

Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA, Australia.

Kidney transplantation restores fertility in patients with end-stage renal disease, with many successful pregnancies after kidney transplantation being reported. , there are little data regarding pregnancy in women transplanted under modern-era desensitisation protocols that utilise rituximab, plasma exchange and intravenous immunoglobulin, including ABO-incompatible transplants. Pregnancies in ABO-incompatible recipients can pose new challenges from an immunological perspective. Read More

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http://journals.sagepub.com/doi/10.1177/1753495X17745390
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http://dx.doi.org/10.1177/1753495X17745390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416689PMC
March 2019
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Complement in Thrombotic Microangiopathies: Unraveling Ariadne's Thread Into the Labyrinth of Complement Therapeutics.

Front Immunol 2019 27;10:337. Epub 2019 Feb 27.

Division of Biodiagnostic Sciences and Technologies, INRASTES, National Center for Scientific Research Demokritos, Athens, Greece.

Thrombotic microangiopathies (TMAs) are a heterogeneous group of syndromes presenting with a distinct clinical triad: microangiopathic hemolytic anemia, thrombocytopenia, and organ damage. We currently recognize two major entities with distinct pathophysiology: thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). Beyond them, differential diagnosis also includes TMAs associated with underlying conditions, such as drugs, malignancy, infections, scleroderma-associated renal crisis, systemic lupus erythematosus (SLE), malignant hypertension, transplantation, HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), and disseminated intravascular coagulation (DIC). Read More

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http://dx.doi.org/10.3389/fimmu.2019.00337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413705PMC
February 2019

Impact of hypertensive emergency and complement rare variants on presentation and outcome of atypical hemolytic uremic syndrome.

Haematologica 2019 Mar 19. Epub 2019 Mar 19.

APHP, Hôpital Européen Georges Pompidou, laboratoire d'Immunologie, INSERM, UMR_S 1138.

Atypical hemolytic uremic syndrome is a prototypic thrombotic microangiopathy attributable to complement dysregulation. Hypertensive emergency, characterized by elevation of systolic (>180mmHg) or diastolic (>120mmHg) blood pressure together with end-organ damage, can cause thrombotic microangiopathy which may mimic atypical hemolytic uremic syndrome. We sought to retrospectively evaluate the clinical, biological and complement genetic characteristics of 76 and 61 atypical hemolytic uremic syndrome patients with and without hypertensive emergency, respectively. Read More

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http://dx.doi.org/10.3324/haematol.2019.216903DOI Listing

Frailty and Cognitive Deficits Limit Access to Kidney Transplantation: Unfair or Unavoidable?

Clin J Am Soc Nephrol 2019 Mar 19. Epub 2019 Mar 19.

Renal-Electrolyte and Hypertension Division and

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.02390219
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http://dx.doi.org/10.2215/CJN.02390219DOI Listing
March 2019
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Frailty and Access to Kidney Transplantation.

Clin J Am Soc Nephrol 2019 Mar 19. Epub 2019 Mar 19.

Department of Surgery,

Background And Objectives: Frailty, a syndrome distinct from comorbidity and disability, is clinically manifested as a decreased resistance to stressors and is present in up to 35% of patient with ESKD. It is associated with falls, hospitalizations, poor cognitive function, and mortality. Also, frailty is associated with poor outcomes after kidney transplant, including delirium and mortality. Read More

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http://dx.doi.org/10.2215/CJN.12921118DOI Listing

Subclinical Cognitive Impairment and Listing for Kidney Transplantation.

Clin J Am Soc Nephrol 2019 Mar 19. Epub 2019 Mar 19.

Departments of Internal Medicine.

Background And Objectives: Cognitive impairment is common in patients with kidney disease and can affect physicians' perception and/or patients' ability to complete the pretransplant evaluation. We examined whether cognitive impairment influences the likelihood for transplant listing and whether patients with cognitive impairment take longer to be listed.

Design, Setting, Participants, & Measurements: We conducted a single-center longitudinal cohort study. Read More

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http://dx.doi.org/10.2215/CJN.11010918DOI Listing

Does Immunosuppression Help Control Alopecia Areata? A Study in Transplant Recipients.

Skinmed 2019 19;17(1):18-22. Epub 2019 Mar 19.

Department of Dermatology, Hospital Clínico San Carlos, Madrid, Spain.

Alopecia areata (AA) is a polygenic autoimmune disease. The immunosuppressant drugs taken by patients who undergo solid organ transplantation might therefore be useful in its control. The literature, however, contains conflicting information in this regard. Read More

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March 2019
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Perioperative management of renal transplant patients undergoing total joint arthroplasty.

J Perioper Pract 2019 Mar 19:1750458919835435. Epub 2019 Mar 19.

Division of Trauma & Orthopaedics Surgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.

The success of renal transplantation depends on lifelong immunosuppression. This can lead to a high incidence of avascular necrosis of major joints in the body for which arthroplasty is the treatment of choice. The risk of surgical complications is high in these patients, and there is no current set of cohesive perioperative management guidelines. Read More

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http://dx.doi.org/10.1177/1750458919835435DOI Listing

Terminal ileitis after kidney transplantation : Crohn's disease or other? Case reports and literature review.

Acta Gastroenterol Belg 2019 Jan-Mar;82(1):63-66

Department of Gastroenterology, UZ Brussels.

The finding of a terminal ileitis after kidney transplantation can cause a diagnostic challenge. Because the development of Crohn's disease under immunosuppressive therapy is unlikely, this diagnosis should only be considered after exclusion of infectious disease and drug-related intestinal toxicity. Defining the underlying cause of terminal ileitis is often hampered by a shortage of specific diagnostic tests or their lack of sensitivity. Read More

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March 2019
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Pure versus hand-assisted retroperitoneoscopic live donor nephrectomy: a retrospective cohort study of 1508 transplants from two centers.

Surg Endosc 2019 Mar 19. Epub 2019 Mar 19.

Department of Urology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, Japan.

Background: Although minimally invasive procedures have been established as the standard for a donor nephrectomy, there are many different surgical techniques described in the literature. The aim of this study is to compare the outcomes of kidney transplant procedures using the pure retroperitoneoscopic donor nephrectomy (PRDN) and hand-assisted retroperitoneoscopic donor nephrectomy (HARDN) techniques.

Methods: A retrospective study involving 1508 transplant procedures was conducted; 874 were PRDN procedures; and 634 were HARDN. Read More

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http://dx.doi.org/10.1007/s00464-019-06697-yDOI Listing

Safety and efficacy of eculizumab in the prevention of antibody-mediated rejection in living-donor kidney transplant recipients requiring desensitization therapy: a randomized trial.

Am J Transplant 2019 Mar 19. Epub 2019 Mar 19.

Department of Nephrology and Organ Transplantation, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, France.

We report results of a phase 2, randomized, multicenter, open-label, two-arm study evaluating the safety and efficacy of eculizumab in preventing acute antibody-mediated rejection (AMR) in sensitized recipients of living-donor kidney transplants requiring pretransplantation desensitization (NCT01399593). In total, 102 patients underwent desensitization. Posttransplantation, 51 patients received standard of care (SOC) and 51 received eculizumab. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.15364
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http://dx.doi.org/10.1111/ajt.15364DOI Listing
March 2019
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Prediction of Renal Allograft Chronic Rejection Using a Model Based on Contrast-Enhanced Ultrasonography.

Microcirculation 2019 Mar 18:e12544. Epub 2019 Mar 18.

Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai Institute of Imaging Medicine, Shanghai, 200032, China.

Objective: To evaluate the application of contrast-enhanced ultrasonography (CEUS) for the diagnosis of renal allograft chronic rejection (CR).

Method: A total of 104 patients who were suspected to have acute rejection (AR) or CR were enrolled in this study (derivation group, n = 66; validation group, n = 38). Before biopsy, all patients received an ultrasound examination. Read More

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http://dx.doi.org/10.1111/micc.12544DOI Listing
March 2019
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The Impact of Intraoperative Fluid Management During Laparoscopic Donor Nephrectomy on Donor and Recipient Outcomes.

Clin Transplant 2019 Mar 19:e13542. Epub 2019 Mar 19.

Department of Surgery, Division of Transplantation, University of Michigan, Ann Arbor, MI, USA.

Background: Intraoperative fluid management during laparoscopic donor nephrectomy (LDN) may have a significant effect on donor and recipient outcomes. We sought to quantify variability in fluid management and investigate its impact on donor and recipient outcomes.

Methods: A retrospective review of patients who underwent LDN from July 2011 to January 2016 with paired kidney recipients at a single center was performed. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ctr.13542
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http://dx.doi.org/10.1111/ctr.13542DOI Listing
March 2019
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Single Center, Real-World Experience with Granulocyte Colony-Stimulating Factor for Management of Leukopenia Following Kidney Transplantation.

Clin Transplant 2019 Mar 19:e13541. Epub 2019 Mar 19.

Department of Pharmacy Services, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Background: Leukopenia is a frequent complication following kidney transplantation. Granulocyte colony-stimulating factor (G-CSF) has been used to accelerate white blood cell (WBC) count recovery; however, published experience in kidney transplantation is limited.

Methods: We retrospectively reviewed our kidney transplant recipients from January 2012 to September 2016 with a G-CSF order to evaluate leukopenia management (defined as WBC < 3000 cells/μL). Read More

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http://dx.doi.org/10.1111/ctr.13541DOI Listing

Oxidative Balance and Inflammation in Hemodialysis Patients: Biomarkers of Cardiovascular Risk?

Oxid Med Cell Longev 2019 11;2019:8567275. Epub 2019 Feb 11.

Department of Nephrology, Dialysis and Transplantation, Kidney and Transplantation Research Center, Annunziata Hospital, Cosenza, Italy.

During chronic kidney disease, the progressive deterioration of renal function induces several biological/clinical dysfunctions, including enhancement of synthesis of inflammation/oxidative stress mediators. Impaired renal function is an independent cardiovascular risk factor; indeed, cardiovascular complications dominate the landscape of both chronic kidney disease and end-stage renal disease. The aim of this study is to explore the correlation between the global oxidative balance in hemodialysis patients and both inflammatory markers and cardiovascular events. Read More

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http://dx.doi.org/10.1155/2019/8567275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388354PMC
February 2019

Kidney Transplantation in a HIV-Positive Recipient.

Clin J Am Soc Nephrol 2019 Mar 18. Epub 2019 Mar 18.

Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, Alabama.

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http://dx.doi.org/10.2215/CJN.14051118DOI Listing

Heart-Kidney and Heart-Liver Transplantation Provide Immunoprotection to the Cardiac Allograft.

Ann Thorac Surg 2019 Mar 15. Epub 2019 Mar 15.

Division of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA. Electronic address:

Background: Prior single-center studies suggest kidney and liver allografts are immunoprotective toward transplanted hearts. The broader effects of simultaneous transplantation of kidney or liver on protection from rejection are unclear.

Methods: The United Network for Organ Sharing database for heart transplantation was queried from 1987 to 2015 and stratified into patients undergoing heart-liver (HLT; n=192), heart-kidney (HKT; n=1174), and heart-only (HT; n=61,471) transplantation. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.02.012DOI Listing

Identifying Important Outcomes for Young People With CKD and Their Caregivers: A Nominal Group Technique Study.

Am J Kidney Dis 2019 Mar 15. Epub 2019 Mar 15.

Sydney School of Public Health, The University of Sydney; Centre for Kidney Research, The Children's Hospital at Westmead, Sydney.

Rationale & Objective: Chronic kidney disease (CKD) has wide-ranging and long-term consequences for young people and their families. The omission of outcomes that are important to young people with CKD and their caregivers limits knowledge to guide shared decision making. We aimed to identify the outcomes that are important to young people with CKD and their caregivers. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.040DOI Listing

Dermal tissue remodeling and non-osmotic sodium storage in kidney patients.

J Transl Med 2019 Mar 18;17(1):88. Epub 2019 Mar 18.

Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: Excess dietary sodium is not only excreted by the kidneys, but can also be stored by non-osmotic binding with glycosaminoglycans in dermal connective tissue. Such storage has been associated with dermal inflammation and lymphangiogenesis. We aim to investigate if skin storage of sodium is increased in kidney patients and if this storage is associated with clinical parameters of sodium homeostasis and dermal tissue remodeling. Read More

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http://dx.doi.org/10.1186/s12967-019-1815-5DOI Listing

Shearing-force injury of a kidney transplant graft during cesarean section: a case report and review of the literature.

BMC Nephrol 2019 Mar 18;20(1):94. Epub 2019 Mar 18.

Department of Obstetrics & Gynecology, University of California, Irvine, 333 City Blvd, West - Suite 1400, Orange, CA, 92868, USA.

Background: With an increasing number of reproductive-aged women undergoing renal transplantation coupled with improved fertility post-transplantation, more women are becoming pregnant with a kidney transplant in place. This leads to increased risk of perinatal complications such as pre-eclampsia, gestational diabetes, preterm delivery and Cesarean section. Given that kidney transplants are often placed extra-peritoneally in the iliac fossa, there is also a risk of damage to the transplanted kidney at the time of Cesarean section. Read More

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http://dx.doi.org/10.1186/s12882-019-1281-6DOI Listing

Lower rate of delayed graft function is observed when epidural analgesia for living donor nephrectomy is administered.

BMC Anesthesiol 2019 Mar 18;19(1):38. Epub 2019 Mar 18.

Department of Anesthesiology and Critical Care, Medical Center, Faculty of Medicine, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.

Background: The beneficial effects of epidural analgesia (EDA) in terms of pain control and postoperative convalescence are widely known and led to a frequent use for patients who underwent living donor kidney nephrectomy. The objective of this study was to determine whether general anesthesia (GA) plus EDA compared to GA only, administered for living donor nephrectomy has effects on postoperative graft function in recipients.

Methods: In this monocentric, retrospective cohort analysis we analyzed the closed files of all consecutive donor- recipient pairs who underwent living donor kidney transplantations from 2008 to 2017. Read More

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http://dx.doi.org/10.1186/s12871-019-0713-yDOI Listing

Statin Therapy Before Transition to End-Stage Renal Disease With Posttransition Outcomes.

J Am Heart Assoc 2019 Mar;8(6):e011869

1 Harold Simmons Center for Kidney Disease Research and Epidemiology Division of Nephrology and Hypertension University of California Irvine Medical Center Orange CA.

Background Although studies have shown that statin therapy in patients with non-dialysis-dependent chronic kidney disease was associated with a lower risk of death, this was not observed in dialysis patients newly initiated on statins. It is unclear if statin therapy benefits administered during the predialysis period persist after transitioning to end-stage renal disease. Methods and Results In 47 720 veterans who transitioned to end-stage renal disease during 2007 to 2014, we examined the association of statin therapy use 1 year before transition with posttransition all-cause and cardiovascular mortality and hospitalization incidence rates over the first 12 months of follow-up. Read More

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http://dx.doi.org/10.1161/JAHA.118.011869DOI Listing

Incidence and Impact of Acute Kidney Injury after Liver Transplantation: A Meta-Analysis.

J Clin Med 2019 Mar 17;8(3). Epub 2019 Mar 17.

Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, MS 39216, USA.

Background: The study's aim was to summarize the incidence and impacts of post-liver transplant (LTx) acute kidney injury (AKI) on outcomes after LTx.

Methods: A literature search was performed using the MEDLINE, EMBASE and Cochrane Databases from inception until December 2018 to identify studies assessing the incidence of AKI (using a standard AKI definition) in adult patients undergoing LTx. Effect estimates from the individual studies were derived and consolidated utilizing random-effect, the generic inverse variance approach of DerSimonian and Laird. Read More

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http://dx.doi.org/10.3390/jcm8030372DOI Listing

[Hemo- and peritoneal dialysis: what non-nephrologists should know].

Authors:
Andreas Fischer

Ther Umsch 2018;75(6):387-394

1 Abteilung für Nephrologie, Luzerner Kantonsspital, Luzern.

Hemo- and peritoneal dialysis: what non-nephrologists should know Abstract. Haemodialysis and peritoneal dialysis are widely available procedures, which prolong life for increasingly old and polymorbid patients with end-stage renal disease. In selected patients dialysis serves a bridging purpose until renal transplantation, in older and frail patients dialysis is performed until the end of life. Read More

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http://dx.doi.org/10.1024/0040-5930/a001013DOI Listing
January 2018

[The renal transplant patient in primary care: do´s and don´ts].

Ther Umsch 2018;75(6):395-400

1 Klinik für Nephrologie und Transplantationsmedizin, Kantonsspital St. Gallen.

The renal transplant patient in primary care: do's and don'ts Abstract. Kidney transplantation is the best therapeutic option for patients with end-stage renal disease regarding mortality, quality of life and cost efficiency. In the medium to long term patients may be seen primarily by the general nephrologist and family physician. Read More

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http://dx.doi.org/10.1024/0040-5930/a001014DOI Listing
January 2018

[Liver transplantation for polycystic liver disease: 11 cases report and literature review].

Zhonghua Yi Xue Za Zhi 2019 Mar;99(10):767-770

Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.

To explore the indications and safety of orthopedic liver transplantation for polycystic liver disease (PLD). Data of 11 patients with PLD who underwent orthotopic liver transplantation between 2004 and 2013 was retrospectively analyzed. Demographic, clinical and follow-up data were collected for statistical analysis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.10.012DOI Listing
March 2019
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[Focus on the occurrence, diagnosis and individualized treatment of tumors after renal transplantation].

Authors:
D J Chen J H Chen

Zhonghua Yi Xue Za Zhi 2019 Mar;99(10):725-727

Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.10.002DOI Listing

Post-transplant lymphoproliferative disorder in pediatric patients: survival rates according to primary sites of occurrence and a proposed clinical categorization.

Am J Transplant 2019 Mar 18. Epub 2019 Mar 18.

Division of Infectious Diseases, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada.

Post-transplant-lymphoproliferative-disorder (PTLD) is a devastating complication of organ transplantation. In a hospital-based registry, we identified biopsy-proven cases of PTLD among children over a 15-year period and reviewed trends in PTLD rates, the sites of involvement and the associated survival rates. Cases that were included had at least 1 year of follow-up after the diagnosis of PTLD. Read More

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http://dx.doi.org/10.1111/ajt.15358DOI Listing