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Diagn Interv Radiol 2019 Jan;25(1):5-13

Department of Radiology, Dokuz Eylül University School of Medicine, İzmir, Turkey.

Purpose: We aimed to evaluate magnetic resonance imaging (MRI) features, including signal intensities, enhancement patterns and T2 signal intensity ratios to differentiate oncocytoma from chromophobe renal cell carcinoma (RCC).

Methods: This retrospective study included 17 patients with oncocytoma and 33 patients with chromophobe RCC who underwent dynamic MRI. Two radiologists independently reviewed images blinded to pathology. Read More

Keio J Med 2018 Nov 23. Epub 2018 Nov 23.

Departments of Uro-Oncology, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan.

Renal oncocytoma is generally regarded as a benign renal tumor. We herein report a case of large renal oncocytoma with renal venous tumor thrombus. The patient may need to be carefully followed up because hematogenous metastasis may occur. Read More

Urol Clin North Am 2018 Aug 15;45(3):311-330. Epub 2018 Jun 15.

Department of Radiology; UT Southwestern Medical Center, 2201 Inwood Road, Suite 210, Dallas, TX 75390, USA. Electronic address:

The increase in serendipitous detection of solid renal masses on imaging has not resulted in a reduction in mortality from renal cell carcinoma. Consequently, efforts for improved lesion characterization have been pursued and incorporated into management algorithms for distinguishing clinically significant tumors from those with favorable histology or benign conditions. Although diagnostic imaging strategies have evolved for optimized lesion detection, distinction between benign tumors and both indolent and aggressive malignant neoplasms remain an important diagnostic challenge. Read More

Radiol Case Rep 2018 Aug 9;13(4):909-913. Epub 2018 Jul 9.

Department of Radiology, University of Alabama in Birmingham, Birmingham, AL, USA.

Ectopic thyroid gland is a developmental anomaly that results from the arrest of thyroid tissue along its path of descent from the floor of mouth to the pre tracheal position in the lower neck. It is typically found along the thyroglossal duct with the base of the tongue being the most common site. Apart from mediastinal extension of goiter, the incidence of true intrathoracic ectopic thyroid tissue is rare. Read More

World J Surg Oncol 2018 Jul 2;16(1):123. Epub 2018 Jul 2.

Department for the Treatment and Study of Abdominal Diseases and Abdominal Transplantation, IRCCS-ISMETT (Istituto di Ricovero e Cura a Carattere Scientifico - Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), UPMC (University of Pittsburgh Medical Center) Italy, Via E. Tricomi 5, 90127, Palermo, Italy.

Background: The ethical implications of the utilization of kidneys with solid renal masses (SRMs) in transplantation are the subject of lively debate in the transplantation community and beyond. One of such implications is that as the life expectancy of renal transplant patients improve, the prevalence of SRMs in donors is likely to increase. We report a case of an oncocytoma in a renal allograft complicating a deceased-donor kidney transplant. Read More

J Bras Nefrol 2018 Jan-Mar;40(1):86-90. Epub 2018 Apr 19.

Hospital Universitário Pedro Ernesto, Vila Isabel, Rio de Janeiro, RJ, Brasil.

Renal oncocytoma is an infrequently reported renal neoplasm, often asymptomatic, which usually behaves as a benign entity and is identified accidentally on radiological imaging. Transplant patients under long-term immunosuppressive drugs have a high prevalence of cancers, such as skin cancers, lymphoproliferative disorders, and renal carcinomas. We present a case report of an asymptomatic renal oncocytoma in a kidney transplant recipient presenting persistent hematuria. Read More

J Med Case Rep 2018 May 21;12(1):146. Epub 2018 May 21.

Departments of Urology and pathology, Kosin University Gospel Hospital, Kosin University College of Medicine, 262 Gamcheon-ro, Seo-gu, Busan, 49267, South Korea.

Background: Renal oncocytoma is the most common benign renal tumor, and papillary renal cell carcinoma is the second most common histologic subtype of renal cell carcinoma. Renal tumors containing different components such as papillary renal cell carcinoma and oncocytoma are extremely rare.

Case Presentation: A renal mass was incidentally detected in a 52-year-old Korean woman, and a computed tomographic scan showed a 32-mm multicystic mass with some calcifications in the lower pole of the right kidney. Read More

Medicine (Baltimore) 2017 Dec;96(48):e8939

Department of Urology.

Rationale: Renal hybrid oncocytic/chromophobe tumors (HOCTs) are benign tumors containing a mixture of cells with features of chromophobe renal cell carcinoma (CHRCC) and renal oncocytoma (RO). Sporadic HOCT, which means HOCT occurs in patients without Birt-Hogg-Dubé syndrome (BHDS) or renal oncocytosis, is extremely rare. In this article, we would report a new case of a patient with both sporadic HOCT and multiple Schwannomas, which is even rarer than simplex sporadic HOCT. Read More

Urology 2018 Apr 2;114:121-127. Epub 2018 Jan 2.

Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Objective: To investigate whether morphologic analysis can differentiate between benign and malignant renal tumors on clinically acquired imaging.

Materials And Methods: Between 2009 and 2014, 3-dimensional tumor volumes were manually segmented from contrast-enhanced computerized tomography (CT) images from 150 patients with predominantly solid, nonmacroscopic fat-containing renal tumors: 100 renal cell carcinomas and 50 benign lesions (eg, oncocytoma and lipid-poor angiomyolipoma). Tessellated 3-dimensional tumor models were created from segmented voxels using MATLAB code. Read More

J Radiol Case Rep 2017 May 31;11(5):27-33. Epub 2017 May 31.

Department of Radiology, UF Health Shands Hospital, Gainesville, FL, USA.

Renal oncocytoma is a benign renal neoplasm that is often discovered incidentally and closely mimics renal cell carcinoma on common imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI). Due to the inability to reliably distinguish between these benign and malignant lesions with imaging, both are typically treated as if they are malignant. Hypermetabolic activity of renal oncocytomas is not frequently encountered because positron emission tomography (PET) is not a standard modality for imaging primary renal tumors. Read More

Ann Nucl Med 2018 Feb 6;32(2):87-93. Epub 2017 Dec 6.

The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St., Baltimore, MD, 21287, USA.

Objective: Technetium-99m (Tc)-sestamibi single-photon emission computed tomography/computed tomography (SPECT/CT) has previously been shown to allow for the accurate differentiation of benign renal oncocytomas and hybrid oncocytic/chromophobe tumors (HOCTs) apart from other malignant renal tumor histologies, with oncocytomas/HOCTs showing high uptake and renal cell carcinoma (RCC) showing low uptake based on uptake ratios from non-quantitative single-photon emission computed tomography (SPECT) reconstructions. However, in this study, several tumors fell close to the uptake ratio cutoff, likely due to limitations in conventional SPECT/CT reconstruction methods. We hypothesized that application of quantitative SPECT/CT (QSPECT) reconstruction methods developed by our group would provide more robust separation of hot and cold lesions, serving as an imaging framework on which quantitative biomarkers can be validated for evaluation of renal masses with Tc-sestamibi. Read More

Urology 2018 Mar 23;113:206-208. Epub 2017 Nov 23.

Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH. Electronic address:

The differential diagnosis of solid renal neoplasms in adolescence includes aggressive malignancy and indolent oncocytic tumors, which are typically indistinguishable using conventional imaging. We report the use of Tc-sestamibi single-photon emission computed tomography / x-ray computed tomography (SPECT/CT) in characterizing enhancing renal neoplasms in a pediatric patient. Genetic testing suggested a hereditary syndrome associated with aggressive malignancy, whereas renal mass biopsy suggested an oncocytic tumor. Read More

J Kidney Cancer VHL 2017 9;4(4):1-12. Epub 2017 Oct 9.

Department of Pathology and Laboratory Medicine and Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI, USA.

Oncocytoma is a well-defined benign renal tumor, with classic gross and histologic features, including a tan or mahogany-colored mass with central scar, microscopic nested architecture, bland cytology, and round, regular nuclei with prominent central nucleoli. As a result of variations in this classic appearance, difficulty in standardizing diagnostic criteria, and entities that mimic oncocytoma, such as eosinophilic variant chromophobe renal cell carcinoma and succinate dehydrogenase-deficient renal cell carcinoma, pathologic diagnosis remains a challenge. This review addresses the current state of pathologic diagnosis of oncocytoma, with emphasis on modern diagnostic markers, areas of controversy, and emerging techniques for less invasive diagnosis, including renal mass biopsy and advanced imaging. Read More

Curr Urol Rep 2017 Sep 12;18(11):86. Epub 2017 Sep 12.

Department of Radiology, University of Alabama at Birmingham School of Medicine, 619 19th Street South, JT N325, Birmingham, AL, 35249-6830, USA.

Purpose Of Review: The majority of enhancing renal masses cannot be characterized through imaging as malignant or benign; however, such characterization could save patients from unnecessary surgery and/or biopsy and associated morbidity. Herein, we review the recent literature on the emerging use of Tc-MIBI SPECT/CT in preoperative differentiation of enhancing renal masses.

Recent Findings: Recent reports have shown that Tc-MIBI SPECT/CT imaging can differentiate mitochondrial-rich, benign, or indolent renal masses from renal cell carcinoma. Read More

Urologia 2017 Oct 11;84(4):244-250. Epub 2017 Aug 11.

Department of Urology, University of Modena and Reggio Emilia, Modena - Italy.

Introduction: Although differentiation between benign and malignant small renal tumors (≤4 cm) is still difficult, it is a demand for decision making and determining the treatment strategy. Our aim is to evaluate the role of multidetector row computed tomography (MDCT) in the differentiation of small renal clear cell carcinoma (RCC) and renal oncocytoma (RO).

Methods: We reviewed triphasic computed tomographic (CT) scans performed in 43 patients diagnosed with RCC (n = 23) and RO (n = 21). Read More

Appl Immunohistochem Mol Morphol 2017 Jul 4. Epub 2017 Jul 4.

*Urology Clinic Departments of †Diagnostics and Public Health ‡General Surgery and Odontoiatrics #Medicine, Renal Unit, University and Hospital Trust, Verona ∥Department of Specialised, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi University Hospital, Bologna ¶Anatomic Pathology, Pederzoli Hospital, Peschiera Del Garda, Italy §Department of Pathology, Faculty of Medicine in Plzen, Charles University, Pilsen, Czech Republic.

The 2016 World Health Organization Renal Tumor Classification defines renal oncocytoma (RO) as a benign epithelial tumor; however, malignant histopathologic features have been documented. Rare cases with metastases have been reported. We describe the case of a 62-year-old woman who was referred to the Urology Clinic for a routine work-up. Read More

Eur Radiol 2017 Dec 19;27(12):4913-4922. Epub 2017 Jun 19.

Department of Radiology, Chinese PLA General Hospital, Fuxing Road 28, Box 100853, Beijing, China.

Objectives: To compare the performance of diffusion-weighted imaging (DWI) with that of contrast-enhanced MRI in differentiating renal oncocytomas from chromophobe renal cell carcinomas (RCCs).

Methods: We recruited 48 patients with histopathologically confirmed renal oncocytomas (n=16) and chromophobe RCCs (n=32). All patients underwent preoperative DWI and contrast-enhanced MRI. Read More

Urology 2017 Sep 24;107:e1-e2. Epub 2017 May 24.

Department of Urology, University of Virginia Health System, Charlottesville, VA.

Tumor-to-tumor metastasis (TTM) is a rare phenomenon where a focus of distinct metastatic disease is discovered with a second primary tumor. Although renal cell carcinoma is the most frequent recipient of metastatic tumor cells, oncocytomas have also previously been described. We present the case of a patient with incidentally detected mammary adenocarcinoma within an oncocytoma 16 years following primary treatment. Read More

Urol Int 2017 8;99(2):229-236. Epub 2017 Mar 8.

USC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Objectives: To evaluate the current accuracy of CT for diagnosing benign renal tumors.

Materials And Methods: We retrospectively reviewed 905 patients who underwent preoperative CT followed by surgical resection. The final pathology was benign in 156 patients (17%). Read More

Abdom Radiol (NY) 2017 06;42(6):1734-1743

Department of Radiology, Massachusetts General Hospital [MGH], Harvard Medical School, Boston, MA, 02114, USA.

Objective: To evaluate whether the Aorta-Lesion-Attenuation-Difference on contrast-enhanced CT can aid in the differentiation of malignant and benign oncocytic renal neoplasms.

Materials And Methods: Two independent cohorts-an initial (biopsy) dataset and a validation (surgical) dataset-with oncocytomas and chromophobe renal cell carcinomas (chRCC) were included in this IRB-approved retrospective study. A region of interest was placed on the renal mass and abdominal aorta on the same CT image slice to calculate an Aorta-Lesion-Attenuation-Difference (ALAD). Read More

BMJ Case Rep 2017 Jan 27;2017. Epub 2017 Jan 27.

Department of Urology, MedStar Georgetown University Hospital, Washington, DC, USA.

Radiol Clin North Am 2017 Mar 12;55(2):243-258. Epub 2016 Dec 12.

Department of Radiology and Advanced Imaging Research Center, UT Southwestern Medical Center, Harry Hines 5323, 2201 Inwood Road, Dallas, TX 75390, USA. Electronic address:

Detection of solid renal masses has increased, although it has not resulted in significant mortality reduction from renal cell carcinoma. Efforts for improved lesion characterization have been pursued and incorporated in management algorithms, in order to distinguish clinically significant tumors from favorable or benign conditions. Concurrently, imaging methods have produced evidence supporting their role as useful tools not only in lesion detection but also characterization. Read More

AJR Am J Roentgenol 2017 Apr 26;208(4):812-819. Epub 2017 Jan 26.

1 Department of Radiology, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Ste 1638, Los Angeles, CA 90095-7437.

Objective: The objective of our study was to investigate the performance of relative enhancement on multiphasic MRI to differentiate clear cell renal cell carcinoma (RCC) from other RCC subtypes (papillary and chromophobe) and oncocytoma.

Materials And Methods: For this study, we derived a cohort of 34 clear cell RCCs, nine oncocytomas, 12 papillary RCCs, and 10 chromophobe RCCs with a preoperative multiphasic dynamic contrast-enhanced MRI study with up to four phases (i.e. Read More

AJR Am J Roentgenol 2017 Feb 13;208(2):343-350. Epub 2016 Dec 13.

1 Department of Radiology, Pellegrin Hospital, Pl Amélie Raba Léon, 33076 Bordeaux, France.

Objective: The purpose of this study was to retrospectively evaluate the diagnostic accuracy of multiparametric MRI to differentiate oncocytoma from chromophobe renal cell carcinoma (RCC).

Materials And Methods: In this retrospective study, 26 histologically confirmed oncocytomas and 16 chromophobe RCCs that underwent full MRI examination were identified in 42 patients (25 men and 17 women) over a 6-year period. Demographic data were recorded. Read More

Int Urol Nephrol 2017 Feb 16;49(2):215-224. Epub 2016 Nov 16.

Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho tr 1946/1, 612 42, Brno, Czech Republic.

Background: Renal cell carcinoma (RCC) represents the most common malignant epithelial neoplasm of the kidney. Accurate assessment of the renal masses, defining the histologic subtype and the grade of differentiation of the tumor, is vital to ensure an adequate case management as well as for staging and prognosis. Recently, diffusion-weighted imaging (DWI) magnetic resonance imaging (MRI) tends to be increasingly appealing for the clinicians as an imaging procedure of choice for the diagnosis and staging of the RCC, which is predetermined by several advantages over CT. Read More

BJU Int 2016 Oct 26;118 Suppl 3:30-34. Epub 2016 Jul 26.

Uropath Pty Ltd, West Leederville, WA, Australia.

Objectives: To evaluate the intermediate outcome of conservative management in patients with biopsy-proven oncocytoma.

Patients And Methods: Patients with oncocytoma diagnosed on percutaneous core biopsy between January 2000 to December 2014 were identified from the renal biopsy database of a large specialist urologic pathology laboratory. After review of patient clinical records, the study cohort comprised only of patients enrolled in active surveillance. Read More

Urology 2016 Dec 3;98:97-102. Epub 2016 Aug 3.

Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Objective: To report a contemporary series of surgically treated patients with tumors involving kidneys with fusion anomalies.

Materials And Methods: We retrospectively reviewed the medical records of all 10 patients treated at a single tertiary care institution for tumors involving kidneys with fusion anomalies between the years 2000 and 2015. One patient, diagnosed with lymphoma, did not undergo surgical treatment and was therefore excluded. Read More

Acta Radiol 2017 May 30;58(5):625-633. Epub 2016 Sep 30.

1 Department of Radiology, Sant'Orsola-Malpighi Hospital, Bologna, Italy.

Background Small renal masses (SRMs; ≤4 cm) represent a challenging issue. Computed tomography (CT) is widely used for investigating renal tumors even if its ability to differentiate among the different subtypes has not yet been definitively established. Purpose To assess the potential role of the morphological features and angiodynamic behavior on multiphasic CT in the preoperative evaluation of SRMs. Read More

Abdom Radiol (NY) 2017 02;42(2):552-560

Keck School of Medicine, University of Southern California, 1500 San Pablo St, 2nd Floor Imaging, Los Angeles, CA, 90033, USA.

Purpose: The purpose of this study was to compare whole-lesion (WL) enhancement parameters to single region of interest (ROI)-based enhancement in discriminating clear cell renal cell carcinoma (ccRCC) from renal oncocytoma.

Materials And Methods: In this IRB-approved retrospective study, the surgical database was queried to derive a cohort of 94 postnephrectomy patients with ccRCC or oncocytoma (68 ccRCC, 26 oncocytoma), who underwent preoperative multiphase contrast-enhanced computed tomography (CECT) between June 2009 and August 2013. CT acquisitions were transferred to a three-dimensional workstation, and WL ROIs were manually segmented. Read More

Oncology (Williston Park) 2016 May;30(5):426-35

J Comput Assist Tomogr 2016 Jul-Aug;40(4):513-6

From the *Russell H. Morgan Department of Radiology and Radiological Science and †The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD.

Objective: A series of renal hybrid oncocytic/chromophobe tumors (HOCTs) was retrospectively assessed for morphologic features and enhancement characteristics by computed tomography (CT).

Materials (subjects) And Methods: Nine patients with pathologically proven HOCTs were identified. These patients harbored a total of 12 lesions. Read More

Singapore Med J 2017 May 19;58(5):262-266. Epub 2016 Apr 19.

Division of Medical Oncology, National Cancer Centre Singapore, Singapore.

Introduction: This study analysed the tumour attenuation characteristics of different subtypes of renal cell carcinomas (RCCs), including clear cell RCC (ccRCC), papillary RCC (pRCC), mixed RCC, chromophobe RCC (chRCC) and oncocytoma.

Methods: We randomly selected 100 RCC cases that underwent nephrectomy between 2004 and 2012 from a collaborative database. Of these cases, 36 were excluded due to the absence of available imaging. Read More

Urologe A 2016 Jul;55(7):941-8

Urologische Klinik, St. Elisabeth Klinikum Straubing, St. Elisabeth-Str. 23, 94315, Straubing, Deutschland.

Bilateral oncocytosis along with multiple tumours in both kidneys represents a very rare pathology that is accompanied by diagnostic and therapeutic challenges. We report the case of a 60-year old male patient who underwent computer tomography with incidental detection of multiple bilateral and contrast enhancing renal tumours of different size. Subsequently the patient underwent nephron-sparing tumor resection, first on the right side and 4 weeks later on the left side. Read More

Radiologia 2016 Mar-Apr;58(2):81-7. Epub 2015 Dec 24.

Servicio de Radiología, Hospital Clínic de Barcelona, Barcelona, España.

Incidental renal lesions are relatively common in daily radiological practice. It is important to know the different diagnostic possibilities for incidentally detected lesions, depending on whether they are cystic or solid. The management of cystic lesions is guided by the Bosniak classification. Read More

Mali Med 2016 ;31(3):45-48

Service de radiologie & de médecine nucléaire CHU du Point « G » Bamako (Mali).

Renal oncocytoma is a rare benign tumor of the kidney. This benign tumor of epithelial origin represents 5% of renal tumors. Preoperative diagnosis is difficult. Read More

Can Urol Assoc J 2015 Sep-Oct;9(9-10):E709-12. Epub 2015 Oct 13.

Department of Urology, Adelaide and Meath hospital, Tallaght, Dublin, Ireland.

Introduction: Oncocytomas have traditionally been treated with surgical excision; however, their excellent long-term prognosis has popularized conservative and minimally invasive ablative techniques. We evaluated the evolving management and natural history of renal oncocytomas and investigated the relationship between radiological and histopathological diagnosis.

Methods: We performed a 17-year retrospective cohort study on all patients with a confirmed histopathological diagnosis of renal oncocytoma. Read More

AJR Am J Roentgenol 2015 Nov;205(5):999-1007

1 Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.

Objective: The purpose of this study was to evaluate whether small (< 4 cm) oncocytomas can be differentiated from renal cell carcinomas (RCCs) on biphasic contrast-enhanced CT.

Materials And Methods: Forty-three patients with 53 oncocytomas and 123 patients with 128 RCCs (24 papillary subtype and 104 clear cell and other subtypes) who underwent biphasic contrast-enhanced CT were included in the study. Patient demographics and CT tumor characteristics were evaluated in each case. Read More

Korean J Urol 2015 Oct 6;56(10):695-702. Epub 2015 Oct 6.

Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.

Purpose: To investigate and distinguish the computed tomography (CT) characteristics of chromophobe renal cell carcinoma (chRCC) and renal oncocytoma.

Materials And Methods: Fifty-one patients with renal oncocytoma and 120 patients with chRCC, diagnosed by surgery between November 2005 and June 2015, were studied retrospectively. Two observers, who were urologists and unaware of the pathological results, reviewed the preoperative CT images. Read More

Eur Urol 2016 Mar 18;69(3):413-6. Epub 2015 Sep 18.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

Unlabelled: Nuclear imaging offers a potential noninvasive means of determining the histology of renal tumors. The aim of this study was to evaluate the accuracy of technetium-99m ((99m)Tc)-sestamibi single-photon emission computed tomography/x-ray computed tomography (SPECT/CT) for the differentiation of oncocytomas and hybrid oncocytic/chromophobe tumors (HOCTs) from other renal tumor histologies. In total, 50 patients with a solid clinical T1 renal mass were imaged with (99m)Tc-sestamibi SPECT/CT prior to surgical resection. Read More

Int Urol Nephrol 2015 Oct 13;47(10):1665-9. Epub 2015 Aug 13.

Department of Urology, James Cook University Hospital, Marton Road, Middlesbrough, TS43GE, UK.

Purpose: To correlate the accuracy of intraoperative and surgical specimen (ex vivo) ultrasound (US) with pathological margin status at partial nephrectomy.

Materials And Methods: Patients undergoing partial nephrectomy for T1 renal tumours in the period May 2010-January 2014 at a single institution who had intraoperative specimen US were included. PN was performed by standardised technique with intraoperative tumour localisation. Read More

Acta Radiol 2016 Apr 13;57(4):500-6. Epub 2015 May 13.

Department of Medical Imaging, Subei People's Hospital, Medical School of Yangzhou University, Yangzhou, PR China.

Background: Renal oncocytoma (RO) and chromophobe renal cell carcinoma (ChRCC) share histologic and some imaging features.

Purpose: To investigate the multidetector computed tomography (MDCT) characteristics of these two tumor types.

Material And Methods: Fifty-six patients with RO and 54 patients with ChRCC were studied retrospectively. Read More

Anticancer Res 2015 Apr;35(4):2351-7

Department of Radiology, Medical School and Teaching Hospital Pilsen, Charles University in Prague, Pilsen, Czech Republic Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.

Background/aim: Diffusion-weighted imaging (DWI) allows for differentiation of benign from malignant tumors, histological tumor types and their grade. The aim of the study was to evaluate the capabilities of DWI using 3 Tesla Magnetic resonance imaging (3T MRI) in the preoperative assessment of renal tumors.

Patients And Methods: This retrospective study included 143 tumors in 139 patients (130 malignant tumors and 13 benign tumors) that were examined using DWI with b values of 50, 400 and 800 s/mm(2). Read More

Ugeskr Laeger 2015 01;177(2A):122-3

Radiologisk Afdeling, Holstebro Sygehus, Lægårdvej 12 C, 7500 Holstebro.

Renal oncocytosis is a rare variant of renal oncocytoma with multiple, often bilateral oncocytomas. This case report discusses radiological and pathological aspects of renal oncocytoma and oncocytosis. Read More

Clin Nucl Med 2015 Apr;40(4):309-13

From the *The Russell H. Morgan Department of Radiology and Radiological Science, †The James Buchanan Brady Urological Institute and Department of Urology, and ‡Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD; and §Department of Nuclear Medicine, University of Würzburg, Würzburg, Germany.

Purpose: The differentiation of oncocytoma from renal cell carcinoma (RCC) remains a challenge with currently available cross-sectional imaging techniques. As a result, a large number of patients harboring a benign oncocytoma undergo unnecessary surgical resection. In this study, we explored the utility of 99mTc-MIBI SPECT/CT for the differentiation of these tumors based on the hypothesis that the large number of mitochondria in oncocytomas would lead to increased 99mTc-MIBI uptake. Read More

Chin Med J (Engl) 2015 Jan;128(2):175-9

Department of Radiology, Beijing Union Hospital, Beijing 100730, China.

Background: The difference between renal oncocytomas (RO) and renal clear cell carcinomas (RCCs) presents the greatest diagnostic challenge. The aim of this study was to retrospectively determine if RO and RCCs could be differentiated on computed tomography (CT) images on the basis of their enhancement patterns with a new enhancement correcting method.

Methods: Forty-six patients with a solitary renal mass who underwent total or partial nephrectomy were included in this study. Read More

Nat Genet 2015 Jan 17;47(1):13-21. Epub 2014 Nov 17.

Molecular Biology Department, Genentech, Inc., South San Francisco, California, USA.

To further understand the molecular distinctions between kidney cancer subtypes, we analyzed exome, transcriptome and copy number alteration data from 167 primary human tumors that included renal oncocytomas and non-clear cell renal cell carcinomas (nccRCCs), consisting of papillary (pRCC), chromophobe (chRCC) and translocation (tRCC) subtypes. We identified ten significantly mutated genes in pRCC, including MET, NF2, SLC5A3, PNKD and CPQ. MET mutations occurred in 15% (10/65) of pRCC samples and included previously unreported recurrent activating mutations. Read More

Histopathology 2014 Sep;65(3):295-308

Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, Wellington, New Zealand.

The use of percutaneous renal tumour biopsy (RTB) as a diagnostic tool for the histological characterization of renal masses has increased dramatically within the last 30 years. This increased utilization has paralleled advances in imaging techniques and an evolving knowledge of the clinical value of nephron sparing surgery. Improved biopsy techniques using image guidance, coupled with the use of smaller gauge needles has led to a decrease in complication rates. Read More

Eur Radiol 2014 Nov 17;24(11):2787-94. Epub 2014 Jul 17.

The Ottawa Hospital, Department of Medical Imaging, The University of Ottawa, 1053 Carling Avenue, Ottawa, Ontario, Canada, K1Y 4E9,

Objectives: Segmental enhancement inversion (SEI) is a controversial imaging finding reportedly specific for the diagnosis of renal oncocytoma. The purpose of this study was to re-evaluate SEI using biphasic CT and multiphase MRI.

Methods: With research ethics board approval, a retrospective analysis of patients with resection or biopsy of oncocytoma or chromophobe renal cell carcinoma (Ch-RCC) between 2008-2012 was performed. Read More

Nan Fang Yi Ke Da Xue Xue Bao 2014 Jun;34(6):890-5

Department of Interventional Ultrasound, General Hospital of PLA, Beijing 100853, China.E-mail:

Objective: To investigate the value of real-time contrast-enhanced ultrasound (CEUS) in the diagnosis and differential diagnosis of renal solid renal lesions (RSLs).

Methods: We retrospectively analyzed 140 cases of 152 RSLs with a mean diameter 3.1∓1. Read More

ANZ J Surg 2016 Jan-Feb;86(1-2):99-100. Epub 2014 Apr 16.

Urology, Royal Newcastle Centre, Newcastle, New South Wales, Australia.