652,209 results match your criteria Renal Oncocytoma Imaging


Ruptured Renal Artery Aneurysm in a Pregnant Woman: Case Report and Literature Review.

Rev Bras Ginecol Obstet 2018 Dec 12. Epub 2018 Dec 12.

Universidade Positivo, Curitiba, PR, Brazil.

Renal artery aneurysms (RAAs) are rare and usually asymptomatic; ∼ 90% of them are unilateral. Once diagnosed during pregnancy, they may rupture, presenting a high maternal-fetal risk. The present study reports the case of a 32-year-old pregnant woman with a 30-week gestational age and a ruptured unilateral RAA. Read More

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December 2018

MAGE genes in the kidney: identification of MAGED2 as upregulated during kidney injury and in stressed tubular cells.

Nephrol Dial Transplant 2018 Dec 11. Epub 2018 Dec 11.

Nephrology, IIS-Fundacion Jimenez Diaz-Universidad Autonoma de Madrid and Fundacion Renal Iñigo Alvarez de Toledo-IRSIN, Madrid, Spain.

Background: Mutations in Melanoma Antigen-encoding Gene D2 (MAGED2) promote tubular dysfunction, suggesting that MAGE proteins may play a role in kidney pathophysiology. We have characterized the expression and regulation of MAGE genes in normal kidneys and during kidney disease.

Methods: The expression of MAGE genes and their encoded proteins was explored by systems biology multi-omics (kidney transcriptomics and proteomics) in healthy adult murine kidneys and following induction of experimental acute kidney injury (AKI) by a folic acid overdose. Read More

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December 2018

Educational level and risk of chronic kidney disease: longitudinal data from the PREVEND study.

Nephrol Dial Transplant 2018 Dec 12. Epub 2018 Dec 12.

Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: The longitudinal association between low education and chronic kidney disease (CKD) and its underlying mechanisms is poorly characterized. We therefore examined the association of low education with incident CKD and change in kidney function, and explored potential mediators of this association.

Methods: We analysed data on 6078 participants from the community-based Prevention of Renal and Vascular End-stage Disease study. Read More

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December 2018

Severe vitamin D deficiency is a risk factor for renal hyperfiltration.

Am J Clin Nutr 2018 Dec;108(6):1342-1351

Department of Internal Medicine, College of Medicine, Institute of Kidney Disease Research.

Background: Vitamin D deficiency is associated with renal progression in chronic kidney disease. Moreover, improvement of clinical outcomes after vitamin D supplementation has been reported in the diabetic and chronic kidney disease population.

Objective: We investigated the association between renal hyperfiltration (RHF) and vitamin D status in a relatively healthy population. Read More

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December 2018

Holographic Reconstructions for Preoperative Planning before Partial Nephrectomy: A Head-to-Head Comparison with Standard CT Scan.

Urol Int 2018 Dec 12:1-6. Epub 2018 Dec 12.

Department of Urology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy.

Background: Preoperative surgical planning before partial nephrectomy (PN) is a time-consuming and fragmentary process.

Objectives: To evaluate the differences in the perception of renal anatomy between holographic reconstruction (HR) versus computed tomography (CT) in patients who are candidate to PN.

Methods: CT scans of 10 consecutive patients with intermediate/high complexity renal masses (R. Read More

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December 2018
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Surgical outcomes of renal transplant recipients after abdominal surgery not connected with transplantation A retrospective case-control study.

Int J Surg 2018 Dec 9. Epub 2018 Dec 9.

Department for General and Visceral Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Background: Due to the increasing number of patients after kidney transplantation, elective and emergency surgery of transplanted patients is becoming a relevant challenge in clinical routine. The current data on complication rate of patients after kidney transplantation, which must undergo another elective or emergency abdominal surgery, is inhomogeneous. Therefore, the aim of our study was to evaluate the outcome of renal transplant patients undergoing abdominal and abdominal wall surgery. Read More

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December 2018

Novel therapeutic approaches in primary hyperoxaluria.

Expert Opin Emerg Drugs 2018 Dec 12:1-9. Epub 2018 Dec 12.

a Division of Pediatric Nephrology , University Childrens Hospital, Universitatsklinikum Bonn , Bonn , Germany.

Introduction: Currently, three types of primary hyperoxaluria (PH I-III) are known, all based on different gene-mutations affecting the glyoxylate metabolism in the liver. Disease hallmark is an increased endogenous oxalate production and thus massively elevated urinary excretion of oxalate and other type-specific metabolites. Hyperoxaluria induces the formation of calcium-oxalate kidney stones and/or nephrocalcinosis. Read More

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December 2018

A fistulating oropharyngeal lesion.

Ear Nose Throat J 2018 Dec;97(12):E15-E17

Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Clinic Arizona, 5777 E. Mayo Blvd., Phoenix, AZ 85084, USA.

Post-transplant lymphoproliferative disorder (PTLD) is a unifying term for a spectrum of lymphoid expansion entities brought about by immunosuppression. It can present throughout the head and neck, and tonsillar involvement is not limited to children. We report the case of a 67-year-old woman who developed odynophagia associated with putrid halitosis 4 months after she had undergone renal transplantation. Read More

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December 2018

Penetration of new antidiabetic medications in East Asian countries and the United States: A cross-national comparative study.

PLoS One 2018 12;13(12):e0208796. Epub 2018 Dec 12.

Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, United States of America.

Background: The number of patients with diabetes is increasing particularly in Asia-Pacific region. Many of them are treated with antidiabetics. As the basis of the studies on the benefit and harm of antidiabetic drugs in the region, the information on patterns of market penetration of new classes of antidiabetic medications is important in providing context for subsequent research and analyzing and interpreting results. Read More

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December 2018

Assessment and management of coronary artery disease in kidney and pancreas transplant candidates.

J Cardiovasc Med (Hagerstown) 2018 Dec 11. Epub 2018 Dec 11.

Department of Medicine, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

: Patients with end-stage renal disease (ESRD) undergoing evaluation for kidney and/or pancreas transplantation represent a population with unique cardiovascular (CV) profiles and unique therapeutic needs. Coronary artery disease (CAD) is common in patients with ESRD, mediated by both the overrepresentation and higher prognostic value of traditional CV risk factors amongst this population, as well as altered cardiovascular responses to failing renal function, likely mediated by dysregulation of the renin-angiotensin-aldosterone system (RAAS) and abnormal calcium and phosphate metabolism. Within the ESRD population, obstructive CAD correlates highly with adverse coronary events, including during the peri-transplant period, and successful revascularization may attenuate some of that increased risk. Read More

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December 2018

Combination of ST2 and B-type natriuretic peptide in diabetic patients with acute heart failure: relation with ventricular stiffness and outcome.

J Cardiovasc Med (Hagerstown) 2018 Dec 11. Epub 2018 Dec 11.

Cardiovascular Diseases Unit, Department of Internal Medicine, Le Scotte Hospital, University of Siena.

Background: Diabetes is a common disease in heart failure and its prevalence ranges from 10 to 30%. ST-2 is a novel biomarker of myocardial fibrosis and remodelling in heart failure and may be involved in the inflammatory process of diabetes mellitus. In this study, we sought: to evaluate levels of ST-2 and B-type natriuretic peptide (BNP) in groups with acute heart failure with and without diabetes; to analyse the prognostic impact of ST-2 over a 6-month follow-up period. Read More

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December 2018

Complementary and integrative medicine in kidney transplantation.

Curr Opin Organ Transplant 2018 Dec 11. Epub 2018 Dec 11.

Division of Nephrology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, New York, USA.

Purpose Of Review: Complementary and integrative medicine (CIM) use is widely prevalent in kidney transplant recipients but studies of efficacy or potential harm are sparse. This review examines prevalence of use of CIM and discusses potential beneficial and harmful aspects of CIM in renal transplant recipients.

Recent Findings: The prevalence of CIM use in kidney transplant patients varies from 12 to 45%. Read More

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December 2018

Delayed graft function in kidney transplantation.

Curr Opin Organ Transplant 2018 Dec 11. Epub 2018 Dec 11.

Transplant Nephrology, Keck Hospital of USC, California, USA.

Purpose Of Review: Delayed graft function (DGF) has several long-term graft implications in the field of kidney transplantation and remains a challenge. The incidence of DGF is on the rise because of an increasing use of marginal kidneys in an era of organ shortage. Risk factors for DGF are numerous and stem from multiple sources in the transplant chain starting from the donor to its final allocation in the recipient. Read More

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December 2018

Peptide receptor radionuclide therapy in gastroenteropancreatic NEN G3: a multicenter cohort study.

Endocr Relat Cancer 2019 Feb;26(2):227-239

Department of Oncology, Haukeland University Hospital, Bergen, Norway.

Peptide receptor radionuclide therapy (PRRT) is an established treatment of metastatic neuroendocrine tumors grade 1-2 (G1-G2). However, its possible benefit in high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN G3) is largely unknown. We therefore aimed to assess the benefits and side effects of PRRT in patients with GEP NEN G3. Read More

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February 2019

Reply to Wolf: Osmotically inactive sodium and potassium storage.

Am J Physiol Renal Physiol 2018 Dec;315(6):F1881-F1884

David Geffen School of Medicine at UCLA , Los Angeles, California.

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December 2018

CORRIGENDUM.

Authors:

Am J Physiol Renal Physiol 2018 Dec;315(6):F1885

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December 2018

Total Synthesis and Biological Evaluation of Sericetin for Protection against Cisplatin-Induced Acute Kidney Injury.

J Nat Prod 2018 Dec 12. Epub 2018 Dec 12.

College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST) , Ajou University , Suwon 16499 , Republic of Korea.

A concise synthesis of sericetin (1) was performed in four steps from readily available 3- O-benzylgalangin (4), featuring electrocyclization to produce the tricyclic core and a sequential aromatic Claisen/Cope rearrangement to incorporate the 8-prenyl group of 1. In addition, the therapeutic potential of sericetin (1), isosericetin (2), and three prenylated tetracyclic synthetic intermediates (11, 12, and 14) against cisplatin-induced nephrotoxicity using renal tubular cells were evaluated. Compound 14 showed therapeutic potential against cisplatin-induced kidney damage. Read More

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December 2018

RECOMMENDATIONS OF THE BRAZILIAN SOCIETY OF HEPATOLOGY FOR THE MANAGEMENT OF ACUTE KIDNEY INJURY IN PATIENTS WITH CIRRHOSIS.

Arq Gastroenterol 2018 Jul-Sep;55(3):314-320

Hospital Português, Unidade de Gastroenterologia e Hepatologia, Salvador, BA, Brasil.

Acute kidney injury is a common complication of cirrhosis, occurring in up to 20% of patients hospitalized with cirrhosis. This field is rapidly changing, with significant advances in classification, biomarkers and therapy over the last few years. On the behalf of the Brazilian Society of Hepatology, a panel of experts in Hepatology and Nephrology reviewed published evidence to integrate findings and develop the recommendations presented in this manuscript. Read More

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EFFECTS OF RENAL DYSFUNCTION ON HEALING OF COLONIC ANASTOMOSIS: EXPERIMENTAL STUDY IN WISTAR RATS.

Arq Bras Cir Dig 2018 Dec 6;31(4):e1398. Epub 2018 Dec 6.

Program of Post-Graduation in Surgical Clinic of the Federal University of Paraná, Curitiba, PR, Brazil.

Background: Chronic kidney disease affects more than 500 million people worldwide. In this context, the uremic toxins present are related to worsening in tissue healing.

Aim: Evaluate on healing of colonic anastomosis in uremic rats, serum and anatomopathological indicators, which may be related to the change tissue repair process. Read More

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December 2018

Clinicopathological Features of Nondiabetic Renal Diseases from Different Age Groups: An Observational Cross-sectional Study.

Chin Med J (Engl) 2018 Dec;131(24):2953-2959

Department of Nephrology, Chinese People's Liberation Army General Hospital, Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing 100853, China.

Background: Diabetes mellitus (DM) has become the leading cause of chronic kidney disease (CKD). Nondiabetic renal diseases (NDRDs) have different clinicopathological features and prognosis from those of diabetic nephropathy. Our study sought to analyze the clinical and pathological features of NDRDs, in different age groups through a cross-sectional study. Read More

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December 2018

Symptomatic treatment of brain metastases in renal cell carcinoma with sorafenib.

J Cancer Res Ther 2018 Dec;14(Supplement):S1223-S1226

Department of Chemotherapy, Cancer Center, Qilu Hospital, Shandong University, Jinan 250012, China.

Brain metastasis is synchronous to the diagnosis of renal cell carcinoma (RCC). The prognosis of brain metastasis in RCC with the current treatment options is dismissal. Therefore, we present a case of an elderly female patient with RCC showing a partial response of brain metastasis after 18 months of 600 mg once daily sorafenib treatment who underwent right-sided nephrectomy. Read More

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December 2018
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Detection of urinary trace elements and pattern recognition analysis in patients with renal cell carcinoma by inductively coupled plasma mass spectrometry.

J Cancer Res Ther 2018 Dec;14(Supplement):S1152-S1157

Department of Chemistry, Key Laboratoryof Analytical Sciences, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.

Objective: This study aims to observe the changes and diagnostic values of urinary trace elements in patients with renal cell carcinoma (RCC).

Methods: A total of 28 RCC patients that had been performed radical surgery for more than 3 years were included into this case-control study; meanwhile, thirty healthy volunteers without kidney diseases were set as the control group over the same period. The levels of various urinary trace elements in both groups were measured, and the results were performed the significance analysis and pattern recognition analysis using with partial least square discriminant analysis and Fisher analysis. Read More

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December 2018

Association of hypoxia-inducible factor-1 alpha gene polymorphism with renal cell carcinoma susceptibility.

J Cancer Res Ther 2018 Dec;14(Supplement):S1105-S1109

Department of Clinical Laboratory, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, P. R. China.

Aim Of Study: Association between hypoxia-inducible factor-1 alpha (HIF-1α) gene polymorphism and renal cell carcinoma (RCC) susceptibility is still being conflicting. This meta-analysis was performed to assess the relationship between HIF-1α C1772T (rs11549465)/G1790A (rs11549467) gene polymorphism and RCC risk.

Materials And Methods: Association studies were identified from the databases of PubMed and CBM-disc (China Biological Medicine Database) as of July 1, 2015, and eligible investigations were included and synthesized using meta-analysis method. Read More

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December 2018

Risk of bleeding after ultrasound-guided jugular central venous catheter insertion in severely thrombocytopenic oncologic patients.

Am J Surg 2019 Jan 27;217(1):133-137. Epub 2018 Jun 27.

Department of Cardiovascular & Thoracic Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, United States; Department of Interventional Radiology, University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address:

Introduction: We sought to assess the incidence and risk factors of bleeding after ultrasound-guided internal jugular (USGIJ) catheter insertion in severely thrombocytopenic cancer patients, as safe platelet (PLT) count threshold remains controversial.

Methods: Retrospective study of 52 patients with hematologic malignancies and severe thrombocytopenia who underwent USGIJ catheter insertion between 2014 and 2016. Group A included patients with prophylactic PLT transfusion and Group B without. Read More

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January 2019

Relationship between amikacin blood concentration and ototoxicity in low birth weight infants.

J Infect Chemother 2019 Jan 24;25(1):17-21. Epub 2018 Oct 24.

Department of Pharmacy, Yamanashi Prefectural Central Hospital, Yamanashi, 400-8506, Japan.

Amikacin (AMK) is used as empiric therapy for severe infections such as sepsis in low birth weight (LBW) infants. AMK administered once daily (OD) in adults is reported to be therapeutically effective and prevent side effects, however, evidence on AMK administration in LBW infants is limited, with no clear indications of effectiveness. We performed therapeutic drug monitoring analysis of 20 infants treated with AMK OD for severe infections such as bacteremia. Read More

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January 2019

Generation of a primary hyperoxaluria type 1 disease model via CRISPR/Cas9 system in rats.

Curr Mol Med 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatric Urology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai. China.

Background: Primary hyperoxaluria type 1 (PH1) is an inherited disease caused by mutations in alanine-glyoxylate aminotransferase (AGXT). It is characterized by abnormal metabolism of glyoxylic acid in liver leading to endogenous oxalate overproduction and deposition of oxalate in multiple organs, mainly the kidney. Patients of PH1 often suffer from recurrent urinary tract stones, and finally renal failure. Read More

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December 2018
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Fecal microbiota analysis of polycystic kidney disease patients according to renal function: A pilot study.

Exp Biol Med (Maywood) 2018 Dec 12:1535370218818175. Epub 2018 Dec 12.

2 Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Impact Statement: The heterogeneity of the renal disease, therapeutic interventions, and the original cause of the renal failure, all directly affect the microbiota. We delineate in this report the direct effect of decreased renal function on the bacterial composition following stringent criteria to eliminate the possibilities of other confounding factors and dissect the direct effects of the uremic milieu. We analyzed the microbiome following three different approaches to further evaluate the effects of mild, moderate and advanced renal insufficiency on the microbiome. Read More

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December 2018

Prohibitin 2-mediated mitophagy attenuates renal tubular epithelial cells injury by regulating mitochondrial dysfunction and NLRP3 inflammasome activation.

Am J Physiol Renal Physiol 2018 Dec 12. Epub 2018 Dec 12.

Division of Nephrology, Shanghai Jiaotong university, China.

Accumulating evidence demonstrates that mitochondrial dysfunction and inflammasome activation play a critical role in the pathogenesis of renal tubular injury through the production of reactive oxygen species and cytokines. Prohibitin 2 (PHB2) is a newly identified intracellular receptor of mitophagy (a type of autophagy) that mediates selective removal of damaged mitochondria, and it could possibly play a renoprotective role in kidney disease. In this study, we confirmed that autophagy is activated in tubular epithelial cells treated with angiotensin II, and that inhibition of autophagy results in tubular cell injury. Read More

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December 2018

Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC.

Am J Physiol Renal Physiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Physiology, Emory University School of Medicine, United States.

While the role of urea in urine concentration is known, the effect of urea handling by the urea transporters, UT-A1 and UT-A3, on sodium balance remains elusive. Serum and urinary sodium concentration is similar between wild-type mice (WT) and UT-A3 null (UT-A3 KO) mice; however, mice lacking both UT-A1 and UT-A3 (UT-A1/A3 KO) have significantly lower serum sodium and higher urinary sodium. Protein expression of renal sodium transporters is unchanged among all three genotypes. Read More

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December 2018

Periostin Induces Kidney Fibrosis after Acute Kidney Injury via the p38 MAPK Pathway.

Am J Physiol Renal Physiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Boramae Medical Center, Korea (South), Republic of.

Periostin plays a crucial role in fibrosis, and acute kidney injury results in a high risk of progression to chronic kidney disease. Therefore, we hypothesized that periostin was involved in the progression of acute kidney injury to kidney fibrosis. Unilateral ischemia-reperfusion injury (UIRI) was induced in 7- to 8-week-old male wild-type and periostin- null mice, and the animals were observed for 6 weeks. Read More

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December 2018

Nudel involvement in the high glucose-induced epithelial-mesenchymal transition of tubular epithelial cells.

Am J Physiol Renal Physiol 2018 Dec 12. Epub 2018 Dec 12.

pathology, Hebei medical university, China.

Nudel is a newly discovered factor related to cell migration. The tubular epithelial-mesenchymal transition (EMT) includes four steps: the loss of the adhesive properties of epithelial cells, the acquisition of a mesenchymal cell phenotype, the destruction of the tubular basal membrane and the migration into the renal interstitium. The purpose of this study was to investigate the role of Nudel in the high glucose-induced EMT of tubular epithelial cells. Read More

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December 2018

MYO-INOSITOL OXYGENASE ACCENTUATES RENAL TUBULAR INJURY INITIATED BY ENDOPLASMIC RETICULUM (ER) STRESS.

Am J Physiol Renal Physiol 2018 Dec 12. Epub 2018 Dec 12.

Ward 6-140, Pathology Department, Northwestern University Medical School, United States.

Besides oxidant stress, ER stress has been implicated in the pathogenesis of various metabolic disorders affecting kidney. These two forms of stresses are not mutually exclusive to each other and may operate by a feedback loop in worsening the cellular injury. To attest to this contention studies were performed to assess if in such a setting there is worsening of tubulo-interstitial injury. Read More

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December 2018

"I Don't Get No Respect" - The Role of Chloride in Acute Kidney Injury.

Am J Physiol Renal Physiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine, Icahn School of Medicine at Mount Sinai, United States.

Acute kidney injury (AKI) is a major public health problem that complicates 10-40% of hospital admissions. Importantly, AKI is independently associated with increased risk of progression to chronic kidney disease, end stage renal disease, cardiovascular events, and increased risk of in-hospital and long-term mortality. The chloride content of intravenous fluid has garnered much attention over the last decade, and its association with excess use and adverse outcomes including AKI. Read More

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December 2018

The impact of obesity as an independent risk factor for the development of renal injury: implications from rat models of obesity.

Am J Physiol Renal Physiol 2018 Dec 12. Epub 2018 Dec 12.

Pharmacology and Toxicology, University of Mississippi Medical Center, United States.

Diabetes and hypertension are the major causes of chronic kidney disease (CKD). Epidemiological studies within the last few decades have revealed that obesity-associated renal disease is a emerging epidemic and that the increasing prevalence of obesity parallels the increased rate of CKD. This has led to the inclusion of obesity as an independent risk factor for CKD. Read More

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December 2018

Unravelling reno-protective effects of SGLT2 inhibition in human proximal tubular cells.

Am J Physiol Renal Physiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Internal Medicine IV, Nephrology and Hypertension, Medical University Innsbruck, Austria.

Large clinical trials demonstrated that SGLT2 inhibitors (SGLT2i) slow the progression of kidney function decline in type 2 diabetes. As the underlying molecular mechanisms are largely unknown, we studied the effects of SGLT2i on gene expression in two human proximal tubular (PT) cell lines under normoglycemic conditions, utilizing two SGLT2i, namely empagliflocin and canagliflocin. Genome-wide expression analysis did not reveal substantial differences between these two SGLT2i. Read More

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December 2018

Detection of Autoantibodies to Complement Components by Surface Plasmon Resonance-Based Technology.

Methods Mol Biol 2019 ;1901:271-280

INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.

The innate immune complement system is a powerful defense cascade against pathogens, but can induce host tissue damage when overactivated. In pathological conditions, mainly but not restricted to renal diseases, such as lupus nephritis, atypical hemolytic uremic syndrome, and C3 glomerulopathies, complement is overactivated or dysregulated by autoantibodies directed against its components and regulators. Among the key autoantibody targets are the initiator of the classical complement pathway C1q, the alternative pathway regulator Factor H, the components of the alternative pathway C3 convertase complex C3 and Factor B and the convertase complex itself. Read More

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January 2019

A Review of the Safety and Adverse Event Profile of the Fixed-Ratio Combination of Insulin Glargine and Lixisenatide.

Diabetes Ther 2018 Dec 11. Epub 2018 Dec 11.

Medical University of South Carolina, Charleston, SC, USA.

Introduction: iGlarLixi is a titratable, fixed-ratio combination of insulin glargine (100 units/mL) and lixisenatide (33 μg/mL). This review evaluates the overall safety and adverse event (AE) profile of iGlarLixi in patients with type 2 diabetes.

Methods: We collated patient-level data from the phase 2 LixiLan proof-of-concept trial and the phase 3 LixiLan-L (insulin-experienced patients) and LixiLan-O (insulin-naïve patients) trials to evaluate AEs associated with iGlarLixi. Read More

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December 2018

APASL clinical practice recommendation: how to treat HCV-infected patients with renal impairment?

Hepatol Int 2018 Dec 11. Epub 2018 Dec 11.

Yamanashi Prefectural Central Hospital, 1-1-1 Fujimi, Kofu-shi, Yamanashi, 400-8506, Japan.

Chronic hepatitis C virus (HCV) infection is common among patients with chronic kidney disease (CKD) and those on hemodialysis due to nosocomial infections and past blood transfusions. While a majority of HCV-infected patients with end-stage renal disease are asymptomatic, some may ultimately experience decompensated liver diseases and hepatocellular carcinoma. Administration of a combination of elbasvir/grazoprevir for 12 weeks leads to high sustained virologic response (SVR) rates in patients with HCV genotypes (GTs) 1a, 1b or 4 and stage 4 or 5 CKD. Read More

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December 2018

Renal intraparenchymal resistive index: the ultrasonographic answer to many clinical questions.

J Nephrol 2018 Dec 11. Epub 2018 Dec 11.

Nephrology and Dialysis Unit, "S. Giovanni di Dio" Hospital, Agrigento, Italy.

The use of renal resistive indices (RRIs) for the study of renal microcirculation has in the past been proposed for the identification of renal organ damage or even to specifically identify injury to some areas of the renal parenchyma. Nevertheless, according to the most recent evidences from literature this organ-based conception of RRIs has been proven to be partial and unable to explain the RRIs variations in clinical settings of sepsis or combined organ failure of primitively extrarenal origin or, more generally, the deep connection between RRIs and hemodynamic factors such as compliance and pulsatility of the large vessels. The aim of this review is to explain the physiopathological basis of RRIs determination and the most common interpretative errors in their analysis. Read More

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December 2018

Percutaneous microwave ablation of renal angiomyolipomas in tuberous sclerosis complex to improve the quality of life: preliminary experience in an Italian center.

Radiol Med 2018 Dec 11. Epub 2018 Dec 11.

Diagnostic and Interventional Radiology Department, ASST Santi Paolo e Carlo, San Paolo Hospital, University of Milan, Via A di Rudinì 8, 20142, Milan, Italy.

Aim: To evaluate efficacy, safety and quality of life of the patients with renal angiomyolipomas (AMLs) associated with tuberous sclerosis complex (TSC) treated with percutaneous microwave ablation (MWA).

Materials And Methods: Nine patients (7 females and 2 males; mean age 27.6 years, range 23-34), with 10 renal AMLs with a mean size of 6. Read More

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December 2018

Acute triflumuron exposure induces oxidative stress responses in liver and kidney of Balb/C mice.

Environ Sci Pollut Res Int 2018 Dec 11. Epub 2018 Dec 11.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dental Medicine, Rue Avicenne, 5019, Monastir, Tunisia.

Triflumuron (TFM) is one of the most widely used insecticides over the world. It is a benzoylphenyl urea that belongs to the class of insect growth regulators. This insecticide acts by inhibiting insect's chitin synthesis and by consequences, making insect more susceptible to pathogens and malformations. Read More

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December 2018

Predictive factors for complications associated with penetrated fish bones outside the upper gastrointestinal tract.

Eur Arch Otorhinolaryngol 2018 Dec 11. Epub 2018 Dec 11.

Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue 1095, Wuhan, 430030, China.

Purpose: To investigate predictive risk factors for complications associated with migrating fish bones in the surrounding tissue of upper gastrointestinal tract.

Methods: A retrospective analysis over 12 years was conducted of 45 cases of buried fish bones in the surrounding tissue of upper gastrointestinal tract with complications. Meanwhile, a control group, including 39 cases of prolonged buried fish bones in the surrounding tissue of upper gastrointestinal tract without complications, was set. Read More

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December 2018
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Trifecta outcome of ureteral reconstruction in iatrogenic injury and non-iatrogenic ureteral lesions: a 10-year experience at a tertiary referral center.

World J Urol 2018 Dec 11. Epub 2018 Dec 11.

Department of Urology, National Taiwan University Hospital, Taipei, Taiwan.

Purpose: To analyze the trifecta outcome (functional, anatomical, and surgical aspects) of surgical reconstruction for ureteral lesions and investigate the factors affecting the success rate of such reconstruction.

Methods: We retrospectively reviewed the data of patients who underwent ureteral reconstruction at our institute between March 2007 and November 2016. Patient profiles, surgical methods, complications, ureteral stenting, laboratory data, and image studies were collected. Read More

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December 2018

Predictors of Surgical Intervention in Dialysis Patients With Infective Endocarditis.

Open Forum Infect Dis 2018 Nov 20;5(11):ofy265. Epub 2018 Oct 20.

Division of Infectious Diseases, Atlanta, Georgia.

Background: The use of valve surgery for infective endocarditis (IE) in end-stage renal disease (ESRD) patients may be different than in the general population. We assessed predictors of early surgery in ESRD patients with IE.

Methods: We conducted a retrospective cohort study among dialysis patients with left-sided IE between 2005 and 2015. Read More

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November 2018

Presence of cadmium residues in muscle, liver and kidney of and histological evidence.

Ital J Food Saf 2018 Sep 7;7(3):7684. Epub 2018 Nov 7.

Department of Veterinary Medicine, University of Bari "Aldo Moro".

Cadmium (Cd) concentrations were evaluated in the samples of kidney, liver and muscle of sixty-six buffaloes regularly slaughtered. Forty were raised in Campania, in the territory between the province of Naples and Caserta and twenty-six were bred in Apulia, in the province of Bari. Two aliquots were prepared for the renal and hepatic samples: one intended for the chemical analysis and the other one intended for histological investigations. Read More

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September 2018

Stereotactic body radiotherapy used as a bridge to liver transplant in patients with hepatocellular carcinoma and Child-Pugh score ≥8 cirrhosis.

J Radiosurg SBRT 2018 ;5(4):261-267

Division of Radiation Oncology, Allegheny Health Network, 320 East North Ave, Pittsburgh, PA 15212, USA.

Introduction: To report on SBRT as a bridge to OLT for patients with HCC and Child-Pugh ≥8 cirrhosis.

Methods: Retrospective review of 15 patients, treated from 2010-2017. Three patients excluded secondary to delisting from prohibitive substance. Read More

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January 2018

Successfully Treated Norovirus- and Sapovirus-Associated Diarrhea in Three Renal Transplant Patients.

Case Rep Infect Dis 2018 12;2018:6846873. Epub 2018 Nov 12.

Sidney Kimmel Medical College at Thomas Jefferson University, Division of Infectious Diseases, 1015 Chestnut Street, Suite 1020, Philadelphia, PA 19107, USA.

Objectives: To examine the burden of norovirus- and sapovirus-related diarrhea in renal transplant patients and to propose the use of nitazoxanide as a therapeutic option for treatment.

Methods: We reviewed three renal transplant patients with viral diarrhea requiring hospitalization due to acute renal failure and signs of graft rejection. All three patients were treated with nitazoxanide. Read More

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November 2018

Tacrolimus in non-Asian patients with SLE: a real-life experience from three European centres.

Lupus Sci Med 2018 2;5(1):e000274. Epub 2018 Nov 2.

Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy.

Objectives: To analyse the real-life practice on the use of Tacrolimus (TAC) in patients with systemic lupus erythematosus (SLE) from three European SLE referral centres.

Methods: Adult patients with SLE regularly followed at three European referral centres were included. Demographics, cumulative organ involvement, treatment history, Systemic Lupus Disease Activity Index (SLEDAI), laboratory features and physician's judgement were collected at baseline and at 3-6-12 months after starting TAC. Read More

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November 2018

F-FDG PET/CT detects Metastatic Renal Cell Carcinoma Masquerading as Primary Breast Malignancy.

Nucl Med Mol Imaging 2018 Dec 27;52(6):475-478. Epub 2018 Oct 27.

3Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

We present the case of a 36-year-old woman who underwent F-FDG PET/CT with suspicion of a primary breast malignancy. However, PET/CT detected an occult renal cell carcinoma with metastases to the thyroid, breast, lungs and lymph nodes. Thyroid and breast metastases are atypical metastatic sites of renal cell carcinoma. Read More

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December 2018

Dental Care for Patients with End-Stage Renal Disease and Undergoing Hemodialysis.

Int J Dent 2018 13;2018:9610892. Epub 2018 Nov 13.

Unit of Periodontology and Dental Hygiene, School of Dental Sciences, Department of Medical, Surgical and Health Sciences, University of Trieste, Italy.

Chronic renal failure is a progressive disease characterized by a gradual destruction of nephrons and a consequent reduction of kidney function. End-stage renal disease (ESRD) necessitates renal replacement therapy as peritoneal dialysis, hemodialysis, or transplantation. Patients affected by ESRD or in hemodialysis are at risk for developing a number of comorbidities including hypertension, anemia, risk of bleeding, susceptibility to infection, medication side effects, and oral manifestations associated with the disease itself and with hemodialysis treatment. Read More

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November 2018
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