828 results match your criteria Renal Lymphoma Imaging


The role of mediastinoscopy in the diagnosis of thoracic disease: 107-case analysis.

Med Glas (Zenica) 2019 Aug 1;16(2). Epub 2019 Aug 1.

Department of Thoracic Surgery, School of Medicine, Canakkale Onsekiz Mart University, Turkey.

Aim To evaluate the efficacy, safety and feasibility of mediastinoscopy in 107 cases with mediastinal lesions that could not be diagnosed histopathologically with other methods. Methods A total of 107 cases (73 males, 34 females; mean age 57.4, range 30-88 years) with mediastinal lymphadenopathy, who underwent mediastinoscopy between 12 September 2012 and 29 November 2018 were examined retrospectively. Read More

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http://ljkzedo.ba/mgpdf/mg31/01_Kapicibasi_1001_A.pdf
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http://dx.doi.org/10.17392/1001-19DOI Listing
August 2019
2 Reads

68Ga CXCR-4 PET/CT Imaging in an Atypical Case of Extramedullary Plasmacytoma Mimicking as Renal Cell Carcinoma.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Nephrology Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Multiple-myeloma (MM) is a malignant plasma cell proliferation disorder and the second most common blood malignancy after non-Hodgkin lymphoma. The chemokine (CXCR-4) receptor analogues are the newer agents being postulated for myeloma imaging and have shown good diagnostic performance. We report a case of plasmacytoma with suspicious renal cell carcinoma, in whom Ga CXCR-4 PET/CT revealed tracer-avid lesion in the left perinephric region. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002574DOI Listing
April 2019
1 Read

Pediatric Renal Neoplasms:: MR Imaging-Based Practical Diagnostic Approach.

Magn Reson Imaging Clin N Am 2019 May;27(2):279-290

Department of Radiology, Seattle Children's, University of Washington, 4800 Sand Point Way Northeast, Seattle, WA 98105, USA.

Pediatric renal tumors may be malignant or benign. Wilms tumor, the most common malignant pediatric renal tumor, arises sporadically or with various syndromes. Renal cell carcinoma typically presents in older children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10649689193000
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http://dx.doi.org/10.1016/j.mric.2019.01.006DOI Listing
May 2019
5 Reads

Predicting Outcomes in Patients With Diffuse Large B-Cell Lymphoma Treated With Standard of Care.

Cancer Inform 2019 15;18:1176935119835538. Epub 2019 Mar 15.

Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA, USA.

In diffuse large B-cell lymphoma (DLBCL), predictive modeling may contribute to targeted drug development by enrichment of the study populations enrolled in clinical trials of DLBCL investigational drugs to include patients with lower likelihood of responding to standard of care. In clinical practice, predictive modeling has the potential to optimize therapy choices in DLBCL. The objectives of this study were to create a model for predicting health outcomes in patients with DLBCL treated with standard of care and determine informative predictors of health outcomes for patients with DLBCL. Read More

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http://dx.doi.org/10.1177/1176935119835538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421613PMC
March 2019
2 Reads

Development and Evaluation of an F-Radiolabeled Monocyclam Derivative for Imaging CXCR4 Expression.

Mol Pharm 2019 Apr 3. Epub 2019 Apr 3.

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine , Imperial College London , Hammersmith Hospital Campus, Du Cane Road , London W12 0NN , U.K.

In humans, C-X-C chemokine receptor type 4 (CXCR4) is a protein that is encoded by the CXCR4 gene and binds the ligand CXCL12 (also known as SDF-1). The CXCR4-CXCL12 interaction in cancer elicits biological activities that result in tumor progression and has accordingly been the subject of significant investigation for detection and treatment of the disease. Peptidic antagonists have been labeled with a variety of radioisotopes for the detection of CXCR4, but the methodology utilizing small molecules has predominantly used radiometals. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00069DOI Listing
April 2019
2 Reads

The diagnostic utility of retroperitoneoscopic tissue biopsy for unresectable retroperitoneal lesions excluding urogenital cancers.

World J Surg Oncol 2019 Feb 18;17(1):35. Epub 2019 Feb 18.

Department of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Background: Retroperitoneal tumors are an uncommon disease known to consist of a diverse group of benign and malignant neoplasms. Treatment of unresectable retroperitoneal lesions requires pathological diagnosis. Here, we report the utility and safety of retroperitoneoscopic biopsy for unresectable retroperitoneal lesions excluding urogenital cancers. Read More

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https://wjso.biomedcentral.com/articles/10.1186/s12957-019-1
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http://dx.doi.org/10.1186/s12957-019-1581-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379945PMC
February 2019
6 Reads

A rare diagnosis of primary native kidney non-hodgkin's lymphoma after kidney transplantation.

Nephrology (Carlton) 2019 Feb;24(2):272

Renal Unit, Department of Medicine, Queen Elizabeth Hospital, Kowloon, Hong Kong SAR.

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http://dx.doi.org/10.1111/nep.13426DOI Listing
February 2019
1 Read

Predicting Response to Immunotherapy by Evaluating Tumors, Lymphoid Cell-Rich Organs, and Immune-Related Adverse Events Using FDG-PET/CT.

Clin Nucl Med 2019 Apr;44(4):e272-e279

Division of Nuclear Medicine, Department of Diagnostic Radiology, Oregon Health & Science University, Portland, OR.

Purpose: To investigate whether the evaluation of tumors, lymphoid cell-rich organs, and immune-related adverse events (IRAE) with F-FDG PET/CT can predict the efficacy and outcome of immunotherapy.

Methods: Forty patients who underwent F-FDG-PET/CT scans before and after therapy with immune checkpoint inhibitors from December 2013 to December 2016 were retrospectively enrolled (malignant melanoma, n = 21; malignant lymphoma, n = 11; renal cell carcinoma, n = 8). SUVmax of the baseline and first restaging scans were evaluated in tumors, spleen, bone marrow, thyroid and pituitary glands, and were correlated to best overall response in the first year after therapy; IRAE-affected areas were also evaluated. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002453DOI Listing
April 2019
3 Reads

BK virus nephropathy and multiorgan involvement in a child with heart transplantation
.

Clin Nephrol 2019 Feb;91(2):107-113

BK virus is a known cause of renal failure in kidney transplant recipients, but there is little data regarding its effect on native kidneys in heart transplant patients. Here, we describe the case of a child who underwent heart transplantation and was later diagnosed with BK virus with multiorgan involvement. This patient was diagnosed with dilated cardiomyopathy at 4 months of age and underwent heart transplantation at the age of 5 years. Read More

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http://dx.doi.org/10.5414/CN109520DOI Listing
February 2019
6 Reads

Natural killer/T-cell lymphoma with concomitant syndrome of inappropriate antidiuretic hormone secretion: A case report and review of literature.

World J Clin Cases 2018 Nov;6(13):694-702

Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.

We report a case of natural killer (NK)/T-cell lymphoma with concomitant syndrome of inappropriate antidiuretic hormone secretion (SIADH). The patient was a 64-year-old woman with a history of nasopharyngeal carcinoma of over 30 years. She was admitted with a chief complaint of intermittent fever for 2 mo. Read More

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http://dx.doi.org/10.12998/wjcc.v6.i13.694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232570PMC
November 2018
7 Reads

Rapidly progressive renal failure due to tubulointerstitial infiltration of peripheral T-cell lymphoma, not otherwise specified accompanied by uveitis: a case report.

BMC Nephrol 2018 Nov 8;19(1):312. Epub 2018 Nov 8.

Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, 71 Nishimichisita Hebita Ishinomaki, Miyagi, 986-8522, Japan.

Background: Rapid decline in renal dysfunction due to primary renal lymphoma, or secondary renal lymphoma by infiltration from a primary origin, is extremely rare. There are notably few reports indicating infiltration of T-cell lymphoma into the kidney.

Case Presentation: A 61-year-old woman with a sudden body rash and liver dysfunction was brought to our hospital presenting with a dull headache and blurred vision. Read More

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http://dx.doi.org/10.1186/s12882-018-1125-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225725PMC
November 2018

Primary renal diffuse large B-Cell lymphoma causing haemodialysis-dependent nephromegaly in a child.

BMJ Case Rep 2018 Sep 26;2018. Epub 2018 Sep 26.

Department of Pediatrics, Section of Nephrology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.

A 4-year-old boy presented with fatigue and was found to have severe kidney injury requiring haemodialysis. A renal ultrasound demonstrated bilateral nephromegaly with mild loss of corticomedullary differentiation but preserved echogenicity. He had a persistent isolated monocytosis. Read More

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http://dx.doi.org/10.1136/bcr-2018-226328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169698PMC
September 2018
15 Reads

[Minimal fat renalangiomyolipoma with multiple lymph nodes enlargement and postoperative refractory lymphatic fistula: a case report and literature review].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Aug;50(4):717-721

Department of Urology, Peking University People's Hospital, Beijing 100044, China.

Renal angiomyolipoma (AML) is a common benign tumor in the urinary system, mainly composed of adipose tissue, blood vessels and muscle tissue. Renal AML is sporadic in most of patients, while a few are associated with tuberous sclerosis. Classical renal AML occurs predominantly in middle-aged females. Read More

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August 2018
20 Reads

Primary Sphenoidal Sinus Lymphoma with Initial Presentation as Unilateral Abducens Nerve Palsy Symptom.

Case Rep Neurol Med 2018 9;2018:5305963. Epub 2018 Jul 9.

Department of Neurology, The Second Hospital of Jilin University, China.

A 48-year-old man presented with 3 days of mild horizontal diplopia in the left direction, followed by the onset of headache 17 days later. A physical examination revealed isolated left abducens nerve palsy. Head computed tomography (CT) and magnetic resonance imaging (MRI) scans revealed soft-tissue density neoplasms that occupied the sphenoidal sinus and further invaded to destroy the clivus. Read More

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https://www.hindawi.com/journals/crinm/2018/5305963/
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http://dx.doi.org/10.1155/2018/5305963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077322PMC
July 2018
29 Reads

From carcinoma through lymphoma to myeloma: a gastric mass diagnostic rollercoaster ride.

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Department of Medical Oncology and Hematology, Division of Hematology, University Hospital Zurich, Zurich, Switzerland.

We describe a dramatic clinical presentation of extramedullary multiple myeloma (MM) in an elderly patient with known monoclonal gammopathy of unknown significance (MGUS). Gastrointestinal symptoms and a gastric mass on imaging studies suggested an advanced solid gastric malignancy. Pathological workup of gastric biopsies first suspected a lymphoma, a second opinion finally confirmed an extramedullary MM. Read More

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http://dx.doi.org/10.1136/bcr-2018-224953DOI Listing
July 2018
2 Reads

Imaging of Solid Renal Masses.

Urol Clin North Am 2018 Aug 15;45(3):311-330. Epub 2018 Jun 15.

Department of Radiology; UT Southwestern Medical Center, 2201 Inwood Road, Suite 210, Dallas, TX 75390, USA. Electronic address:

The increase in serendipitous detection of solid renal masses on imaging has not resulted in a reduction in mortality from renal cell carcinoma. Consequently, efforts for improved lesion characterization have been pursued and incorporated into management algorithms for distinguishing clinically significant tumors from those with favorable histology or benign conditions. Although diagnostic imaging strategies have evolved for optimized lesion detection, distinction between benign tumors and both indolent and aggressive malignant neoplasms remain an important diagnostic challenge. Read More

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http://dx.doi.org/10.1016/j.ucl.2018.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057157PMC
August 2018
23 Reads

Biomarkers for Clinical Benefit of Immune Checkpoint Inhibitor Treatment-A Review From the Melanoma Perspective and Beyond.

Front Immunol 2018 28;9:1474. Epub 2018 Jun 28.

Section of Dermatooncology, Department of Dermatology and National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.

Background: Immune checkpoint inhibition (ICI) with anti-CTLA-4 and/or anti-PD-1 antibodies is standard treatment for metastatic melanoma. Anti-PD-1 (pembrolizumab, nivolumab) and anti-PD-L1 antibodies (atezolizumab, durvalumab, and avelumab) have been approved for treatment of several other advanced malignancies, including non-small-cell lung cancer (NSCLC); renal cell, and urothelial carcinoma; head and neck cancer; gastric, hepatocellular, and Merkel-cell carcinoma; and classical Hodgkin lymphoma. In some of these malignancies approval was based on the detection of biomarkers such as PD-L1 expression or high microsatellite instability. Read More

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http://dx.doi.org/10.3389/fimmu.2018.01474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031714PMC
June 2018
23 Reads

Acute Kidney Injury by Renal Hemosiderosis Secondary to Primary Cold Agglutinin Disease Associated with an Excessive Alcohol Intake.

Intern Med 2018 Nov 6;57(22):3261-3265. Epub 2018 Jul 6.

Nephrology Center, Toranomon Hospital, Japan.

Renal hemosiderosis occurs in the context of severe intravascular hemolysis, with the most common cause being paroxysmal nocturnal hematuria. Patients with cold agglutinin disease (CAD) have relatively mild hemolysis, and acute kidney injury (AKI) due to renal hemosiderosis has not been reported. We encountered a patient with CAD caused by lymphoplasmacytic lymphoma who developed AKI secondary to renal hemosiderosis after an excessive alcohol intake. Read More

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http://dx.doi.org/10.2169/internalmedicine.0710-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287995PMC
November 2018
6 Reads

Pitfalls in the radiological response assessment of immunotherapy.

Memo 2018 21;11(2):138-143. Epub 2018 Mar 21.

1Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.

Immunotherapies comprise of a class of cancer therapies that are increasingly used for treatment of several cancer entities. Active immunotherapies encompassing immune checkpoint inhibitors are the most widespread class of immunotherapies, with indications for melanoma, non-small lung cancer, renal cell carcinoma, urothelial carcinoma, head and neck squamous cell carcinoma, and Hodgkin's lymphoma. Immune checkpoint inhibitors have demonstrated unique response patterns that are not adequately captured by traditional response criteria such das the Response Evaluation Criteria in Solid Tumors (RECIST) and World Health Organization criteria. Read More

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http://dx.doi.org/10.1007/s12254-018-0389-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006274PMC
March 2018
24 Reads

Metachronous renal Ewing sarcoma/primitive neuroectodermal tumour in a survivor of Burkitt lymphoma.

BMJ Case Rep 2018 Jun 11;2018. Epub 2018 Jun 11.

Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.

We present a case of a 14-year-old girl who was diagnosed with Burkitt lymphoma in 2014. She was managed with chemotherapy and remained in remission for 3 years. On her surveillance imaging in 2017, a left-sided renal neoplastic mass was incidentally discovered. Read More

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http://dx.doi.org/10.1136/bcr-2017-224071DOI Listing
June 2018
9 Reads

[CEUS-diagnosis of solid renal tumors].

Radiologe 2018 Jun;58(6):553-562

Institut für Radiologie, Krankenhaus Landshut-Achdorf, Landshut, Deutschland.

Clinical Issue: Renal lesions are detected earlier, often as a result of ultrasound examinations. However, the imaging-based differential diagnosis of different tumour entities remains challenging STANDARD RADIOLOGICAL METHODS: All renal tumours >1 cm should be evaluated for malignancy by computed tomography (CT) or magnetic resonance imaging (MRI). If an angiomyolipoma diagnosis cannot be established with imaging, further diagnostics are appropriate or if malignant progression is suspected, then multidisciplinary discussion for TNM-staging based uro-oncologic therapy is usual. Read More

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http://dx.doi.org/10.1007/s00117-018-0392-6DOI Listing

Evaluation of the diagnostic utility of cytologic examination of renal fine-needle aspirates from dogs and the use of ultrasonographic features to inform cytologic diagnosis.

J Am Vet Med Assoc 2018 May;252(10):1247-1256

OBJECTIVE To describe cytologic characteristics of renal fine-needle aspirate (FNA) samples from dogs, evaluate proportions of cytologic specimens deemed adequate for interpretation (diagnostic yield), assess diagnostic utility of cytologic examination for neoplastic and nonneoplastic diseases, and characterize ultrasonographic features of evaluated kidneys to determine whether the imaging characteristics could be used to inform cytologic interpretations. DESIGN Retrospective, observational study. SAMPLE 102 cytologic specimens and 97 ultrasonographic studies from 100 dogs. Read More

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http://dx.doi.org/10.2460/javma.252.10.1247DOI Listing
May 2018
12 Reads

[Renal affection in malignant lymphoma: imaging patterns in magnet resonance imaging].

Rofo 2018 07 25;190(7):587-589. Epub 2018 Apr 25.

Department of Diagnostic and Interventional Radiology, University Hospital of Leipzig, Germany.

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http://dx.doi.org/10.1055/a-0591-4867DOI Listing
July 2018
3 Reads

Protective and recuperative effects of 3-bromopyruvate on immunological, hepatic and renal homeostasis in a murine host bearing ascitic lymphoma: Implication of niche dependent differential roles of macrophages.

Biomed Pharmacother 2018 Mar 20;99:970-985. Epub 2018 Feb 20.

School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi, 221005, India. Electronic address:

3-bromopyruvate (3-BP) possesses promising antineoplastic potential, however, its effects on immunological homeostasis vis a vis hepatic and renal functions in a tumor bearing host remain unclear. Therefore, the effect of 3-BP administration to a murine host bearing a progressively growing tumor of thymoma origin, designated as Dalton's lymphoma (DL), on immunological, renal and hepatic homeostasis was investigated. Administration of 3-BP (4 mg/kg) to the tumor bearing host reversed tumor growth associated thymic atrophy and splenomegaly, accompanied by altered cell survival and repertoire of splenic, bone marrow and tumor associated macrophages (TAM). Read More

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http://dx.doi.org/10.1016/j.biopha.2018.01.149DOI Listing
March 2018
11 Reads
2.020 Impact Factor

PAX8-Positive B-Cell Lymphoma in Adrenal Gland Masquerading as Metastatic Renal Cell Carcinoma.

Int J Surg Pathol 2018 Dec 18;26(8):721-724. Epub 2018 Apr 18.

1 University of Washington Medical Center, Seattle, WA, USA.

Extranodal lymphomas involve adrenal glands as a mass lesion in 3% to 5% of cases as identified by imaging studies. Definitive diagnosis of the neoplasm is provided by morphological and immunophenotypical evaluation on limited tissue obtained by fine needle aspiration or core biopsy. We report a diagnostically challenging case that presented as masses involving adrenal gland and lung in the setting of a concurrent primary renal cell carcinoma. Read More

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http://dx.doi.org/10.1177/1066896918770022DOI Listing
December 2018
4 Reads

Splenosis: a great mimicker of neoplastic disease.

Abdom Radiol (NY) 2018 Nov;43(11):3054-3059

Section of Abdominal Imaging, Imaging Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, 44195, USA.

Splenosis is a benign condition that can occur after splenic trauma or after surgery involving the spleen. These splenic implants are most often seen within the abdominal and pelvic cavities. On imaging, splenosis can be confused with multiple additional entities including metastatic disease, peritoneal carcinomatosis, peritoneal mesothelioma, abdominal lymphoma, renal cancer, hepatic adenomas, or endometriosis depending on its distribution. Read More

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http://link.springer.com/10.1007/s00261-018-1601-5
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http://dx.doi.org/10.1007/s00261-018-1601-5DOI Listing
November 2018
8 Reads

Evaluation and Management of Cardiac Tumors.

Curr Treat Options Cardiovasc Med 2018 Mar 20;20(4):29. Epub 2018 Mar 20.

Department of Cardiology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd. Unit 1451, Houston, TX, 77030, USA.

Purpose Of Review: Our purpose is to discuss the importance of multimodality imaging in the assessment of cardiac tumors and management. We have compiled a recent review of the scientific literature and embedded our clinical pathways and recommendations based on data and clinical experience.

Recent Findings: The use of contrast echocardiography in the assessment of cardiac masses has been shown to be helpful in distinguishing tumor from thrombus. Read More

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http://dx.doi.org/10.1007/s11936-018-0625-zDOI Listing
March 2018
20 Reads

Late duodenal metastasis from renal cell carcinoma with newly developed malignant lymphoma: A case report.

Mol Clin Oncol 2018 Apr 31;8(4):553-556. Epub 2018 Jan 31.

Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo 064-0804, Japan.

Duodenal metastasis from renal cell carcinoma (RCC) is rare. The current case report presents a very rare case of late duodenal metastasis from RCC with newly developed malignant lymphoma (diffuse large B-cell lymphoma: DLBCL) at the same time. A 64-year-old man with systemic lymph nodes swelling who had undergone left nephrectomy for RCC 25 years previously, was admitted to the present hospital. Read More

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http://dx.doi.org/10.3892/mco.2018.1563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844005PMC
April 2018
9 Reads

Successful treatment of concomitant metastatic prostate cancer and B-cell non-Hodgkin's lymphoma with R-EPOCH chemotherapy regimen and antiandrogen therapy.

BMJ Case Rep 2018 Mar 16;2018. Epub 2018 Mar 16.

Faculty of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia.

A 70-year-old man presented with left loin pain without urinary symptoms. Initial investigations with CT showed enlarged para-aortic, mediastinal lymph nodes, right-side renal mass and enlarged prostate. A prostatic-specific antigen (PSA) was alarmingly high at 4750 μg/L (normal <4. Read More

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http://dx.doi.org/10.1136/bcr-2017-223637DOI Listing
March 2018
7 Reads

Obstructive jaundice as primary presentation of a stage IIE Non-Hodgkin lymphoma: A decision making process between advanced lymphoma and locally advanced/metastatic pancreatic adenocarcinoma.

Int J Surg Case Rep 2018 7;44:226-229. Epub 2018 Mar 7.

Department of General Surgery, General Hospital of Drama, Drama, Greece.

Introduction: Secondary pancreatic tumors are uncommon and account for 2-5% of pancreatic cancer. Tumors characterized most commonly with pancreatic involvement are lymphoma, renal cell and lung carcinomas.

Presentation Of Case: A 76-year-old female patient with obstructive jaundice as the primary symptom and inguinal lymphadenopathy is presented. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.02.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857486PMC
March 2018
3 Reads

In Vivo PET Assay of Tumor Glutamine Flux and Metabolism: In-Human Trial of F-(2S,4R)-4-Fluoroglutamine.

Radiology 2018 05 31;287(2):667-675. Epub 2018 Jan 31.

From the Department of Radiology (M.P.S.D., W.W., J.S.L.), Department of Medicine (J.J.H., J.B., A.M.O., J.J.H., I.K.M., J.F.G., D.P.K.), Radiochemistry and Molecular Imaging Probe Core (H.Z., E.M.B., S.K.L., J.S.L.), and Department of Medical Physics (B.J.B., P.B.Z.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Room S113E, New York, NY 10065; Molecular Pharmacology and Chemistry Program, Sloan Kettering Institute, New York, NY (H.Z., K.S., J.S.L.); Department of Radiology, Weill-Cornell Medical College, New York, NY (M.P.S.D., W.W., J.S.L.); Laboratory of Neural Systems, the Rockefeller University, New York, NY (C.P.); Department of Pathology, University of Michigan, Ann Arbor, Mich (S.V.); and Departments of Radiology and Pharmacology, University of Pennsylvania, Philadelphia, Pa (H.F.K.).

Purpose To assess the clinical safety, pharmacokinetics, and tumor imaging characteristics of fluorine 18-(2S,4R)-4-fluoroglutamine (FGln), a glutamine analog radiologic imaging agent. Materials and Methods This study was approved by the institutional review board and conducted under a U.S. Read More

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http://dx.doi.org/10.1148/radiol.2017162610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929369PMC
May 2018
16 Reads
6.870 Impact Factor

Dentate nucleus T1 hyperintensity: is it always gadolinium all that glitters?

Radiol Med 2018 Jun 27;123(6):469-473. Epub 2018 Jan 27.

Imaging Department, Bambino Gesù Children's Hospital, Rome, Italy.

In the last few years, several scientific papers and reports have demonstrated magnetic resonance (MR) signal intensity (SI) changes on pre-contrast T1-weighted images following multiple gadolinium-based contrast agents (GBCA) administrations, particularly following the exposure to linear GBCAs. Pathological animal and human post-mortem studies have confirmed the relationship between this radiological finding and the presence of gadolinium accumulation in vulnerable brain regions in patients with normal renal function. In this short communication, we report the case of a 15-year-old patient affected by b-cell acute lymphoblastic leukemia (bALL) who developed a hyperintense signal in the dentate nuclei following multiple administrations of a macrocyclic GBCA. Read More

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http://dx.doi.org/10.1007/s11547-017-0846-3DOI Listing
June 2018
5 Reads

Worth a second look: outcomes of patients with initial finding of regular renal tissue in CT-guided renal tumor biopsies.

World J Urol 2018 May 25;36(5):789-792. Epub 2018 Jan 25.

Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Introduction And Objective: Renal tumor biopsy is recommended for histological diagnosis of radiologically indeterminate renal masses, to select patients with small-renal masses for surveillance approaches, before ablative treatments and to confirm metastatic spread of renal cell cancer (RCC), according to the EAU guidelines. We aimed to determine outcomes of patients with suspicious renal masses with initial finding of regular renal tissue in renal tumor biopsies.

Methods: Retrospective database analysis of 101 patients undergoing CT-guided-, percutaneous renal tumor biopsies in local anesthesia. Read More

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http://dx.doi.org/10.1007/s00345-017-2170-xDOI Listing
May 2018
4 Reads

Extensive Metastatic Sarcomatoid Renal Cell Carcinoma Evaluated by F-FDG PET/CT: a Case Report and Review of Literature.

J Kidney Cancer VHL 2018 12;5(1):1-6. Epub 2018 Jan 12.

Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA.

Sarcomatoid renal cell carcinoma (sRCC) is a highly aggressive form of dedifferentiated renal cell carcinoma. We report a 62-year-old man who presented with respiratory symptoms and a lung mass on chest computed tomography (CT). The patient underwent positron emission tomography/computed tomography (PET/CT) with F-fluorodeoxyglucose (F-FDG) and was found to have extensive metastatic disease. Read More

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http://dx.doi.org/10.15586/jkcvhl.2018.99DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771372PMC
January 2018
1 Read

Primary Renal Cell Lymphoma: Case Report, Diagnosis, and Management.

Indian J Med Paediatr Oncol 2017 Oct-Dec;38(4):545-547

Department of Hematology and Oncology, Indraprastha Apollo Hospitals, New Delhi, India.

The symptoms of primary renal lymphoma (PRL) may mimic a renal cell carcinoma. Since the diagnosis is mostly after a radical nephrectomy, we recommend a percutaneous biopsy or cytology from the renal mass in patients who have features suggestive of a lymphoma. A magnetic resonance imaging may give an image more specific for a lymphoma. Read More

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http://dx.doi.org/10.4103/ijmpo.ijmpo_167_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759080PMC
January 2018
3 Reads

Computed tomography and magnetic resonance imaging of peripelvic and periureteric pathologies.

Abdom Radiol (NY) 2018 Sep;43(9):2400-2411

Department of Radiology, Tıp Fakültesi Hastanesi, School of Medicine, Hacettepe University, Sıhhiye, 06100, Ankara, Turkey.

Peripelvic and periureteric areas are frequently overlooked in the imaging evaluations of the urinary system on computed tomography and magnetic resonance imaging. Several neoplastic and non-neoplastic disorders and diseases including lipomatosis, angiomyolipoma and angiolipomatous proliferation, vascular lesions, lymphangiomatosis, Rosai-Dorfman disease, Erdheim-Chester disease, extramedullary hematopoiesis, IgG4-related disease, lymphoma, mesenchymal tumors, trauma, and Antopol-Goldman lesion may involve these areas. Differentiation of these benign or malignant pathologies among themselves and from primary renal pathologies is of utmost importance to expedite the triage of patients for correct treatment approach. Read More

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http://link.springer.com/10.1007/s00261-017-1444-5
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http://dx.doi.org/10.1007/s00261-017-1444-5DOI Listing
September 2018
5 Reads

Rare Tumors and Lesions of the Pancreas.

Surg Clin North Am 2018 Feb;98(1):169-188

Department of Surgery, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL 32224, USA. Electronic address:

There are a few entities that account for most solid and cystic masses of the pancreas. The pancreas harbors a wide array of diseases, including adenocarcinoma, and its variants, such as anaplastic and adenosquamous carcinoma. Other neoplasms include acinar cell carcinoma, solid pseudopapillary tumor, and sarcomas. Read More

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http://dx.doi.org/10.1016/j.suc.2017.09.013DOI Listing
February 2018
8 Reads

Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes.

Nat Commun 2017 11 22;8(1):1692. Epub 2017 Nov 22.

Department of Microbiology & Immunology, Weill Cornell Medicine, New York, NY, 10065, USA.

Proteasome inhibitors benefit patients with multiple myeloma and B cell-dependent autoimmune disorders but exert toxicity from inhibition of proteasomes in other cells. Toxicity should be minimized by reversible inhibition of the immunoproteasome β5i subunit while sparing the constitutive β5c subunit. Here we report β5i-selective inhibition by asparagine-ethylenediamine (AsnEDA)-based compounds and present the high-resolution cryo-EM structural analysis of the human immunoproteasome. Read More

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http://dx.doi.org/10.1038/s41467-017-01760-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700161PMC
November 2017
21 Reads

Renal osteodystrophy presenting as a metabolic superscan on F-18 FDG PET/CT: A case report.

Medicine (Baltimore) 2017 Nov;96(46):e8471

Department of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Pretoria, South Africa.

Rationale: F-18 Fluoro Deoxyglucose positron emission tomography and computed tomography (F-18 FDG PET/CT) is a useful modality in the evaluation of patients with malignancies. Increased incidence of lympho-proliferative disorders has been reported in individuals with long-standing end-stage renal disorders treated with renal replacement therapy.

Patient Concerns: A 30-year-old male on peritoneal dialysis on account of end-stage renal disease. Read More

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http://dx.doi.org/10.1097/MD.0000000000008471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704796PMC
November 2017
13 Reads

Immune Checkpoint Inhibitor Cancer Therapy: Spectrum of Imaging Findings.

Radiographics 2017 Nov-Dec;37(7):2132-2144

From the Departments of Radiology (G.X.W., V.K., S.I.L., F.J.F.) and Medicine (J.F.G., R.J.S., K.T.F.), Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Founders 210, Boston, MA 02114.

Immune checkpoint inhibitors are a new class of cancer therapeutics that have demonstrated striking successes in a rapid series of clinical trials. Consequently, these drugs have dramatically increased in clinical use since being first approved for advanced melanoma in 2011. Current indications in addition to melanoma are non-small cell lung cancer, head and neck squamous cell carcinoma, renal cell carcinoma, urothelial carcinoma, and classical Hodgkin lymphoma. Read More

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http://dx.doi.org/10.1148/rg.2017170085DOI Listing
April 2018
8 Reads

Evaluation of Multidetector Computed Tomography in Haematuria.

Maedica (Buchar) 2017 Jun;12(2):87-94

Department of Radiodiagnosis and Imaging, M.M. Institute of Medical Sciences and Research, Mullana (Distt -Ambala), Haryana, India.

Aims And Objectives: (1) To study the role of multidetector computed tomography in patients with haematuria. (2) To correlate multidetector computed tomography findings with clinical outcome/laboratory findings/FNAC and/or operative findings (wherever performed).

Material And Methods: The present study was carried out in the Department of Radiodiagnosis, M. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649039PMC
June 2017
3 Reads

Comparison of DWIBS/T2 image fusion and PET/CT for the diagnosis of cancer in the abdominal cavity.

Exp Ther Med 2017 Oct 22;14(4):3754-3760. Epub 2017 Aug 22.

Department of Neurosurgery, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284-0003, Japan.

Fusion images of diffusion-weighted whole-body imaging with background body signal suppression and T2-weighted image (DWIBS/T2) demonstrate a strong signal for malignancies, with a high contrast against the surrounding tissues, and enable anatomical analysis. In the present study, DWIBS/T2 was compared with F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) for diagnosing cancer in the abdomen. Patient records, including imaging results of examination conducted between November 2012 and May 2014, were analyzed retrospectively. Read More

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http://dx.doi.org/10.3892/etm.2017.4987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639341PMC
October 2017
16 Reads

Uncommon Presentation of Primary Renal Lymphoma.

Iran J Kidney Dis 2017 10;11(5):344

Department of Nephrology, Hasheminejhad Kidney Center, Iran University of Medical Sciences, Tehran, Iran.

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October 2017
2 Reads

Radiological manifestations of immune-related adverse effects observed in patients with melanoma undergoing immunotherapy.

J Med Imaging Radiat Oncol 2017 Dec 11;61(6):759-766. Epub 2017 Oct 11.

Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

Immunotherapy drugs work by stimulating the patient's own immune system to recognize and destroy cancer cells. This subclass of drugs is increasingly administered to patients with advanced melanoma. They are also commonly incorporated into other cancer therapies such as non-small cell lung cancer, renal cancer, head and neck cancers and Hodgkin lymphoma. Read More

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http://dx.doi.org/10.1111/1754-9485.12653DOI Listing
December 2017
38 Reads

A case of anaplastic lymphoma kinase-positive renal cell carcinoma coincident with Hodgkin lymphoma.

Pathol Int 2017 Dec 12;67(12):626-631. Epub 2017 Oct 12.

Faculty of Medicine, Department of Diagnostic Pathology, Oita University, Yufu, Japan.

We report a case of ALK-positive renal cell carcinoma coincident with Hodgkin lymphoma. The patient was a 19 year-old-girl without sickle cell trait. The right renal tumor was discovered concomitantly with Hodgkin lymphoma (HL). Read More

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http://dx.doi.org/10.1111/pin.12592DOI Listing
December 2017
8 Reads

EBV-positive post-transplant lymphoproliferative disorder presenting as primary diffuse large B-cell lymphoma of the central nervous system.

Folia Neuropathol 2017 ;55(3):221-226

Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) is a rare complication with inferior survival outcomes in solid organ transplant patients. It represents approximately 7-15% of all PTLD patients. Because of the rarity of this disease, the diagnosis of PCNS-PTLD is often challenging, and the optimal therapy has not been established. Read More

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http://dx.doi.org/10.5114/fn.2017.70487DOI Listing
September 2018
45 Reads

Delayed Development of Hemolytic Anemia with Fragmented Red Blood Cells and Cardiac and Renal Impairments after High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation for Malignant Lymphoma.

Acta Haematol 2017;138(3):152-161. Epub 2017 Oct 4.

Department of Hematology, Tenri Hospital, Tenri, Japan.

Among 42 consecutive patients with malignant lymphoma who underwent high-dose chemotherapy (HDC) followed by autologous hematopoietic stem cell transplantation (AHSCT), 5 developed hemolytic anemia with fragmented red blood cells (HA-FrRBCs) on days 87-125 (median 107) of AHSCT. Nadir Hb levels ranged between 5.0 and 6. Read More

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http://dx.doi.org/10.1159/000480288DOI Listing
June 2018
5 Reads

The value of F-FDG PET/CT in the distinction between retroperitoneal fibrosis and its malignant mimics.

Semin Arthritis Rheum 2018 02 3;47(4):593-600. Epub 2017 Aug 3.

Department of Rheumatology, Chinese PLA General Hospital, Beijing, China. Electronic address:

Objective: To discuss the utility of F-fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) in the diagnosis of idiopathic retroperitoneal fibrosis (iRPF).

Methods: IRPF patients diagnosed between September 2011 and June 2016 were included. Retroperitoneal malignancy patients were included as control. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172173026
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http://dx.doi.org/10.1016/j.semarthrit.2017.07.011DOI Listing
February 2018
28 Reads

Renal Tumors of Childhood: Radiologic-Pathologic Correlation Part 2. The 2nd Decade: From the Radiologic Pathology Archives.

Radiographics 2017 Sep-Oct;37(5):1538-1558

From the Department of Radiology and Radiological Sciences, F. Edward Hébert School of Medicine (A.J.F.), Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 (E.M.C., G.E.L.); Pediatric Radiology Section (E.M.C.) and Genitourinary Radiology Section (G.E.L.), American Institute for Radiologic Pathology, Silver Spring, Md; Department of Radiology (K.E.F.) and Office of Graduate Medical Education (A.M.K., M.A.P.), Walter Reed National Military Medical Center, Bethesda, Md; and Department of Pathology, Eastern Virginia Medical School, Norfolk, Va (R.M.C.).

Malignant renal tumors account for 7% of childhood cancers, and Wilms tumors are by far the most common-but not in older children and adolescents. Among individuals in the latter half of their 2nd decade of life, renal cell carcinoma (RCC) is more common than Wilms tumor. The histopathologic spectrum of RCCs in children differs from that in adults. Read More

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http://dx.doi.org/10.1148/rg.2017160189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621729PMC
December 2017
95 Reads