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    Living-Donor Kidney Transplant in a Patient With Type B Mayer-Rokitansky-Küster-Hauser Syndrome, Reconstructed Vagina, and Abnormal Pelvic Vessels: A Case Report.
    Exp Clin Transplant 2017 May 22. Epub 2017 May 22.
    From the Nephrology and Dialysis Unit, Fondazione I.R.C.C.S. Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.
    Mayer-Rokitansky-Küster-Hauser syndrome is a rare disorder consisting of vaginal aplasia and other müllerian duct abnormalities. Urinary tract malfor-mations possibly leading to renal failure are also common. For these patients, kidney transplant remains the best option. Read More

    Chronic kidney disease: A likely underestimated component of multimorbidity in older patients with chronic obstructive pulmonary disease.
    Geriatr Gerontol Int 2017 May 16. Epub 2017 May 16.
    Unit of Geriatric and Respiratory Medicine, University Campus BioMedico, Rome, Italy.
    The coexistence of chronic kidney disease and chronic obstructive pulmonary disease, two age-related conditions, has important clinical and prognostic implications. Respiratory failure is associated with important changes in glomerular and tubulointerstitial function. In contrast, renal failure can affect lung function, mainly by adding a restrictive component or causing complications, such as uremic pulmonary edema and pleural effusion. Read More

    Restless leg syndrome in chronic hemodialysis patients in Mashhad hemodialysis centers.
    J Renal Inj Prev 2017 25;6(2):137-141. Epub 2016 Dec 25.
    Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
    Introduction: Restless leg syndrome (RLS) is a sensory motor disorder. Patients with this syndrome have serious and uncontrollable desire to move their legs, which is mostly due to an uncomfortable feeling intensified when they are motionless. It may be a genetic disorder or secondary to iron deficiency, neurodegenerations, pregnancy, some drugs and severe kidney diseases. Read More

    Angiogenesis and Inflammation in Peritoneal Dialysis: The Role of Adipocytes.
    Kidney Blood Press Res 2017 May 4;42(2):209-219. Epub 2017 May 4.
    Chronic inflammation and angiogenesis are the most common complications in patients undergoing maintenance peritoneal dialysis (PD), resulting in progressive peritoneum remolding and, eventually, utrafiltration failure. Contributing to the deeper tissue under the peritoneal membrane, adipocytes play a neglected role in this process. Some adipokines act as inflammatory and angiogenic promoters, while others have the opposite effects. Read More

    The effect of Hepatitis C Virus infection on cardiovascular complications in end stage kidney disease patients on regular hemodialysis.
    Electron Physician 2017 Feb 25;9(2):3857-3861. Epub 2017 Feb 25.
    MD, Assistant Professor, Nephrology Department, National Institute of Urology and Nephrology, Cairo, Egypt.
    Introduction: Cardiovascular complications are the most important cause of mortality in patients with ESKD, such as coronary artery disease, left ventricular hypertrophy, heart failure and arrhythmia. Other well-known risk factors, such as diabetes mellitus, hypertension and dyslipidemia are prevalent in ESKD, yet they are not sufficient enough to explain the high prevalence of cardiovascular mortality, hence searching for other hidden risk factors to explain this high prevalence is of an utmost importance. The aim of this study was to identify the exact mechanisms connecting HCV infection, chronic liver disease, and atherogenesis. Read More

    Evaluation of Renal Function in Patients Undergoing Lung Transplantation.
    Transplant Proc 2017 May;49(4):699-701
    Division of Thoracic Surgery, Department of General Surgery and Organ Transplant "PARIDE STEFANINI", Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
    Background: Acute kidney injury and chronic kidney failure are serious complications after lung transplantation. Glomerular filtration rate (GFR) is the primary indicator of renal function. Several equations have been proposed to evaluate the estimated GFR (eGFR). Read More

    Disparities in dialysis allocation: An audit from the new South Africa.
    PLoS One 2017 18;12(4):e0176041. Epub 2017 Apr 18.
    Division of Nephrology and Hypertension, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, Western Cape, South Africa.
    End Stage Kidney Disease (ESKD) is a public health problem with an enormous economic burden. In resource limited settings management of ESKD is often rationed. Racial and socio-economic inequalities in selecting candidates have been previously documented in South Africa. Read More

    Vegetarian Diet in Chronic Kidney Disease-A Friend or Foe.
    Nutrients 2017 Apr 10;9(4). Epub 2017 Apr 10.
    Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Zeromskiego 113, 90-549 Lodz, Poland.
    Healthy diet is highly important, especially in patients with chronic kidney disease (CKD). Proper nutrition provides the energy to perform everyday activities, prevents infection, builds muscle, and helps to prevent kidney disease from getting worse. However, what does a proper diet mean for a CKD patient? Nutrition requirements differ depending on the level of kidney function and the presence of co-morbid conditions, including hypertension, diabetes, and cardiovascular disease. Read More

    Protocol of randomized control trial for effectiveness of angiotensin receptor blockers on blood pressure control among euvolemic hypertensive hemodialysis patients.
    Medicine (Baltimore) 2017 Apr;96(14):e6198
    aDiscipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang bCKD Resource Centre, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan cSchool of Pharmacy, Monash University, Jalan Lagoon Selatan, Bandar Sunway, Selangor, Malaysia.
    Introduction: Volume overload and the renin-aldosterone-angiotensin system (RAAS) are 2 major factors contributing to hypertension (HTN) among hemodialysis (HD) patients. Although volume-dependent components of HTN can be corrected by appropriate volume removal, a proportion of HD patients experience elevated blood pressure (BP) despite achieving euvolemic and ideal dry weight.

    Method And Analysis: A single center, prospective, randomized, parallel design, single-blind trial will be conducted in the Malaysian state of Kelantan among postdialysis euvolemic hypertensive patients that are on regular dialysis at least 3 times a week. Read More

    Nicorandil attenuates neuronal mitochondrial dysfunction and oxidative stress associated with murine model of vascular calcification.
    Acta Neurobiol Exp (Wars) 2017 ;77(1):57-67
    Vascular Biology Lab, SASTRA University, Thanjavur, India,
    Evidences suggest that the presence of chronic kidney disease (CKD) is associated with cerebrovascular diseases related cognitive decline in dialysis patients. As mitochondrial dysfunction is implicated in neurodegenerative disorders, we hypothesized that changes in brain mitochondria occur due to vascular calcification induced by renal failure and the opening of the mitochondrial potassium channel using nicorandil may prevent its dysfunction. Brain tissues from rats with vascular calcification were studied. Read More

    Independent correlates of chronic kidney disease awareness among adults with type 2 diabetes.
    J Diabetes Complications 2017 Jun 18;31(6):988-991. Epub 2017 Mar 18.
    Department of Medicine, Division of General Internal Medicine, Froedtert and The Medical College of Wisconsin, 9200 W. Wisconsin Ave, Milwaukee, WI, USA 53226; Center for Patient Care and Outcomes Research, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, USA 53226. Electronic address:
    Background: Chronic Kidney Disease (CKD) is usually silent until advanced stages. Awareness of CKD is important to mitigate poorer outcomes. This study aims to understand the relationship(s) between CKD self-awareness and diagnosed CKD. Read More

    The effectiveness and safety of angiotensin-converting enzyme inhibition or receptor blockade in vascular diseases in patients with hemodialysis.
    Medicine (Baltimore) 2017 Mar;96(13):e6525
    aDepartment of Internal Medicine, Chi Mei Medical Center, Chiali, Tainan bDepartment of Nephrology cDepartment of Pharmacy, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu dSchool of Pharmacy, Master Program in Clinical Pharmacy, Kaohsiung Medical University eDepartment of Pharmacy, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C.
    Patients with end-stage renal disease (ESRD) who are on hemodialysis have high risk of vascular diseases. Our study sought to examine whether angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin type 1 receptor blockers (ARBs) could reduce the frequencies of cardiovascular and cerebrovascular events in patients receiving hemodialysis using the medication possession ratio (MPR) method of analysis.This retrospective cohort study identified cases of ESRD with dialysis from the National Health Insurance Research Database between 1999 and 2006, and used Cox-regression methods to evaluate risk of poor outcomes. Read More

    Imaging of Myocardial Fibrosis in Patients with End-Stage Renal Disease: Current Limitations and Future Possibilities.
    Biomed Res Int 2017 2;2017:5453606. Epub 2017 Mar 2.
    John Walls Renal Unit, Leicester General Hospital, Leicester, UK; Department of Cardiovascular Science, NIHR Leicester Cardiovascular Biomedical Research Unit, Leicester, UK; Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
    Cardiovascular disease in patients with end-stage renal disease (ESRD) is driven by a different set of processes than in the general population. These processes lead to pathological changes in cardiac structure and function that include the development of left ventricular hypertrophy and left ventricular dilatation and the development of myocardial fibrosis. Reduction in left ventricular hypertrophy has been the established goal of many interventional trials in patients with chronic kidney disease, but a recent systematic review has questioned whether reduction of left ventricular hypertrophy improves cardiovascular mortality as previously thought. Read More

    Near death by milk of magnesia.
    BMJ Case Rep 2017 Mar 21;2017. Epub 2017 Mar 21.
    Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
    We report a case of hypermagnesemia associated with the use of milk of magnesia in a male patient with end-stage renal disease. After experiencing nausea and vomiting, he developed severe bradycardia and then asystole. Resuscitation efforts were successful; however, he developed atrial fibrillation with severe widening of the QRS and diffuse ST elevation, hypothermia, hypotension and apnoea requiring intubation. Read More

    Transcatheter Aortic Valve Implantation in Patients With Advanced Chronic Kidney Disease.
    Am J Cardiol 2017 May 10;119(9):1438-1442. Epub 2017 Feb 10.
    Division of Cardiology, A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy.
    Advanced chronic kidney disease (CKD) is associated with poor outcomes in patients who underwent surgical aortic valve replacement, whereas its prognostic role in transcatheter aortic valve implantation (TAVI) remains unclear. This study aimed to investigate outcomes in patients with advanced CKD who underwent TAVI. A total of 1,904 consecutive patients who underwent balloon-expandable TAVI in 33 centers between 2007 and 2012 were enrolled in the Italian Transcatheter Balloon-Expandable Valve Implantation Registry. Read More

    Etiology of End-Stage Renal Disease and Arterial Stiffness among Hemodialysis Patients.
    Biomed Res Int 2017 19;2017:2543262. Epub 2017 Feb 19.
    Lebanese American University School of Medicine, Byblos, Lebanon; University Medical Center-Rizk Hospital, Beirut, Lebanon.
    Background. Prior studies have demonstrated that conventional and emerging CV risk factors are associated with worsening arterial stiffness among end-stage renal disease (ESRD) patients on hemodialysis. The present cross-sectional study evaluates the association between the etiology of ESRD and arterial stiffness among a cohort of hemodialysis patients. Read More

    [Exhaustion of vascular capital in patients on hemodialysis: what will be the outcome?]
    Pan Afr Med J 2016 19;25:237. Epub 2016 Dec 19.
    Service de Médecine Interne A, Hôpital Charles Nicolle, Tunis, Tunisie; Laboratoire de Pathologie Rénale LR00SP01, Hôpital Charles Nicolle, Tunis, Tunisie.
    Despite advances in the treatment of chronic renal failure, vascular access remains the weakest link in renal replacement therapy (RRT) and the leading cause of morbidity in patients on hemodialysis We report the case of a young female patient with chronic renal insufficiency secondary to vascular nephropathy on periodic hemodialysis and whose vascular capital was early exhausted due to iterative thromboses in arteriovenous fistulas and failure in peritoneal dialysis. Protein C deficiency was objectified. The patient underwent tunneled hemodialysis catheter insertion at the level of the right atrium via a right anterolateral thoracotomy with cannulation of the inferior vena cava, with poor functional outcome after three months of use. Read More

    [Somatotropic axis and molecular markers of mineral metabolism in children undergoing chronic peritoneal dialysis].
    Rev Chil Pediatr 2017 02;88(1):119-127
    Unidad de Nefrología Infantil, Hospital Luis Calvo Mackenna, Santiago, Chile.
    Growth failure is one of the most relevant complications in children with chronic kidney disease (CKD). Among others, growth hormone (GH) resistance and bone mineral disorders have been identified as the most important causes of growth retardation.

    Objectives: 1. Read More

    Copeptin Associates with Cause-Specific Mortality in Patients with Impaired Renal Function: Results from the LURIC and the 4D Study.
    Clin Chem 2017 May 9;63(5):997-1007. Epub 2017 Mar 9.
    Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany.
    Background: In chronic kidney disease (CKD) arginine vasopressin (AVP) cannot efficiently act via renal V2-receptors. AVP is upregulated leading to augmented activation of V1a- and V1b-receptors, which might contribute to the increase in cardiovascular and infectious complications in CKD. Here, we evaluate copeptin, a surrogate of AVP, and its association with cause specific mortality among patients within the whole spectrum of renal function. Read More

    Coronary Plaque Characteristics in Hemodialysis-Dependent Patients as Assessed by Optical Coherence Tomography.
    Am J Cardiol 2017 May 9;119(9):1313-1319. Epub 2017 Feb 9.
    Clinical Trials Center, Cardiovascular Research Foundation, New York, New York; Division of Cardiology, New York-Presbyterian Hospital/Columbia University Medical Center, New York, New York. Electronic address:
    Coronary arteries in patients with chronic kidney disease (CKD) have been shown to exhibit more extensive atherosclerosis and calcium. We aimed to assess characteristics of coronary plaque in hemodialysis (HD)-dependent patients using optical coherence tomography (OCT). This was a multicenter, retrospective study of 124 patients with stable angina who underwent OCT imaging. Read More

    Percutaneous Endovascular Treatment to Salvage Non-Maturing Arteriovenous Fistulas in a Multiethnic Asian Population.
    Ann Acad Med Singapore 2017 Feb;46(2):64-71
    Department of Diagnostic Radiology, Singapore General Hospital, Singapore.
    Introduction: An arteriovenous fistula (AVF) is the preferred method for haemodialysis in patients with end-stage renal failure. Previous studies have shown value in attempting percutaneous transluminal angioplasty (PTA) to salvage AVFs that fail to mature, but they are relatively small in size and mainly reported in Western populations. We reviewed our data of PTA in non-maturing AVFs to establish whether this technique is translatable to our local multiethnic population. Read More

    [Bilateral nephrectomy in patients with end-stage renal failure and chronic active pyelonephritis].
    Urologiia 2016 Feb(1):46-50
    Department of Urology of City Hospital 52, Moscow HCD.
    This study analyzed the results of bilateral nephrectomy in 14 patients with end-stage renal disease (ESRD) and chronic active pyelonephritis. Seven patients had urosepsis, and 10 patients had a purulent form of pyelonephritis, which was one-sided in 7 of them. In the early postoperative period, on average, after 9. Read More

    Hypoalbuminemia Predicts Perioperative Morbidity and Mortality after Infrainguinal Lower Extremity Bypass for Critical Limb Ischemia.
    Ann Vasc Surg 2017 May 27;41:169-175.e4. Epub 2017 Feb 27.
    Division of Vascular and Endovascular Surgery, Boston Medical Center, Boston University, School of Medicine, Boston, MA. Electronic address:
    Background: Poor nutritional status has been associated with a higher risk of morbidity and mortality in general surgery patients; however, outcomes in vascular surgery patients are unclear. Our goal was to determine the effect of poor nutritional status on perioperative morbidity and mortality after lower extremity bypass (LEB).

    Methods: The 2005-2012 National Surgical Quality Improvement Program was analyzed to determine associated complications, mortality, length of stay (LOS), and readmissions for patients with hypoalbuminemia (serum albumin <3. Read More

    Cardiovascular disease in haemodialysis: role of the intravascular innate immune system.
    Nat Rev Nephrol 2017 May 27;13(5):285-296. Epub 2017 Feb 27.
    Department of Immunology, Genetics and Pathology (IGP), Rudbeck Laboratory C5:3, Uppsala University, SE-751 85 Uppsala, Sweden.
    Haemodialysis is a life-saving renal replacement modality for end-stage renal disease, but this therapy also represents a major challenge to the intravascular innate immune system, which is comprised of the complement, contact and coagulation systems. Chronic inflammation is strongly associated with cardiovascular disease (CVD) in patients on haemodialysis. Biomaterial-induced contact activation of proteins within the plasma cascade systems occurs during haemodialysis and initially leads to local generation of inflammatory mediators on the biomaterial surface. Read More

    Ureteral Reconstruction With Ileum: Long-term Follow-up of Renal Function.
    Urology 2017 Feb 22. Epub 2017 Feb 22.
    Department of Urology, Indiana University School of Medicine, Indianapolis, IN. Electronic address:
    Objective: To assess long-term renal preservation and surgical outcomes in patients undergoing ureteric substitution with ileum. This has been a mainstay of reconstruction options for lengthy ureteral defects.

    Methods: Consecutive patients aged 18 or older undergoing ileal ureters at our institution were retrospectively reviewed (from 1989 to June 2013). Read More

    Lung Ultrasound in Hemodialysis: A Card to be Played?
    Blood Purif 2017 23;44(1):1-7. Epub 2017 Feb 23.
    Nephrology and Dialysis Unit, "S. Maria della Scaletta" Hospital, Imola, Italy.
    The end-stage renal disease is characterized by a profound impairment in the regulation of body fluid distribution, and volume assessment in hemodialysis is one of the challenging goals for the nephrologist. To determine a state of euvolemia, different validated techniques have been employed and among them lung ultrasonography (LUS) has recently attracted growing attention on account of its capacity to estimate accurately extra vascular lung water and to detect lung edema even in its early asymptomatic stage, that is, hidden lung congestion.With its noninvasiveness, freedom from radiation, the ease of use, acceptable intra/inter-operator reproducibility and availability of portable ultrasound devices, LUS can be considered one of the most interesting "cards to play" for the volume assessment in patients on hemodialysis. Read More

    Thirty-day and 90-day hospital readmission after outpatient upper extremity hemodialysis access creation.
    J Vasc Surg 2017 May 20;65(5):1376-1382. Epub 2017 Feb 20.
    Division of Vascular and Endovascular Surgery, Boston Medical Center, Boston University School of Medicine, Boston, Mass.
    Objective: Patients with end-stage renal disease have multiple comorbidities and are at increased risk for postoperative complications and resource utilization. Our goal was to determine the rate and causes of 30-day and 90-day hospital readmissions after the creation of outpatient hemodialysis access.

    Methods: We retrospectively reviewed all outpatient upper extremity hemodialysis access creations performed at our medical center from 2008 to 2015. Read More

    Dialysis access, infections, and hospitalisations in unplanned dialysis start patients: results from the OPTiONS study.
    Int J Artif Organs 2017 Mar 11;40(2):48-59. Epub 2017 Feb 11.
    Integrated Market Access, QuintilesIMS, Reading - UK.
    Introduction: Unplanned dialysis start (UPS) associates with worse clinical outcomes, higher utilisation of healthcare resources, lower chances to select dialysis modality and UPS patients typically commenced in-centre haemodialysis (HD) with central venous catheter (CVC). We evaluated patient outcomes and healthcare utilisation depending on initial dialysis access (CVC or PD catheter) and subsequent pathway of UPS patients.

    Methods: In this study patient demographics, access procedures, hospitalisations, and major infectious complications were analysed over 12 months in 270 UPS patients. Read More

    Comparison of clinical and laboratory parameters in patients with end-stage renal failure in the outcome of chronic glomerulonephritis and patients with end-stage renal failure in the outcome of other diseases.
    Wiad Lek 2016;69(6):739-741
    Federal State Autonomous Institution Of Higher Education "North-Eastern Federal University Named After M.K. Ammosov", Yakutsk, Russia.
    Background: frequent complications of hemodialysis treatments are coagulation disorders. This is due to activation of the coagulation of blood flow in the interaction with a dialysis membrane material vascular prostheses and extracorporeal circuit trunks. In addition, in hemodialysis patients receiving heparin for years, there is depletion of stocks in endothelial cells in tissue factor inhibitor, inhibits the activity of an external blood clotting mechanism. Read More

    Abnormally High and Heterogeneous Bone Matrix Mineralization After Childhood Solid Organ Transplantation: A Complex Pathology of Low Bone Turnover and Local Defects in Mineralization.
    J Bone Miner Res 2017 May 1;32(5):1116-1125. Epub 2017 Mar 1.
    Children's Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
    Chronic renal, liver, and heart failure in children associates with multiple skeletal complications. Increased fracture incidence often persists after transplantation and could be related to alterations in bone material properties. In the present cohort study we evaluated bone mineralization density distribution (BMDD) by quantitative backscattered electron imaging (qBEI) in 23 pediatric solid organ allograft recipients with suspected osteoporosis. Read More

    CE: Improving Outcomes for Patients with Chronic Kidney Disease: Part 2.
    Am J Nurs 2017 Mar;117(3):26-35
    Jenna M. Norton is the program manager of the National Kidney and Urologic Science Translation Program at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD. Andrew S. Narva is the director and Eileen P. Newman is the associate director of the National Kidney Disease Education Program in the Division of Kidney, Urologic, and Hematologic Diseases at the NIDDK. Gayle Romancito is a nurse at the Zuni Comprehensive Community Health Center, Indian Health Service, Zuni, NM. Stephanie Mahooty is an NP at Renal Medicine Associates and Desert Kidney Associates in Albuquerque, NM. Theresa Kuracina is a dietitian at the Albuquerque Indian Health Center, Indian Health Service, Albuquerque, NM. Authors Narva, Newman, and Norton are federal employees of the National Institutes of Health, and Romancito and Kuracina are federal employees of the Indian Health Service. Contact author: Andrew S. Narva, The authors and planners have disclosed no potential conflicts of interest, financial or otherwise.
    : Coping with chronic kidney disease (CKD) is challenging for many people, since symptoms often don't appear until the disease is advanced and the patient is close to requiring dialysis. This two-part article aims to provide nurses with the basic information necessary to assess and manage patients with CKD. Part 1, which appeared last month, offered an overview of the disease, described identification and etiology, and discussed ways to slow disease progression. Read More

    Visual evoked potentials in diagnostics of optic neuropathy associated with renal failure.
    Postepy Hig Med Dosw (Online) 2017 Jan 22;71(0):32-39. Epub 2017 Jan 22.
    Uniwersyteckie Centrum Okulistyki i Onkologii Samodzielnego Publicznego Szpitala Klinicznego Śląskiego Uniwersytetu Medycznego w Katowicach; Klinika Okulistyki Katedry Okulistyki, Wydział Lekarski w Katowicach Śląskiego Uniwersytetu Medycznego w Katowicach.
    Chronic renal failure is associated with many neurological complications. Due to accumulation of uremic neurotoxins axonal degeneration with its secondary demyelination occurs, which results in development of polineuropathy in 60‑100% of patients with chronic renal failure. One of the most severe peripheral neuropathy is optic neuropathy. Read More

    A contemporary evaluation of carotid endarterectomy outcomes in patients with chronic kidney disease in the United States.
    Vascular 2017 Jan 1:1708538117691430. Epub 2017 Jan 1.
    1 Division of Vascular Surgery, University of Missouri, School of Medicine, Columbia, MO, USA.
    Objectives Chronic kidney disease (CKD) has been identified as a significant risk factor for poor post-surgical outcomes. This study was designed to provide a contemporary analysis of carotid endarterectomy (CEA) outcomes in patients with CKD, end-stage renal disease (ESRD), and normal renal function (NF). Methods The Nationwide Inpatient Sample data 2006-2012 was queried to select patients aging 40 years old and above who underwent CEA during two days after admission and had a diagnosis of ESRD on long-term hemodialysis, patients with non-dialysis-dependent CKD, or NF. Read More

    Free and total p-cresol sulfate levels and infectious hospitalizations in hemodialysis patients in CHOICE and HEMO.
    Medicine (Baltimore) 2017 Feb;96(6):e5799
    aDepartment of Medicine, University of California San Francisco, San Francisco bDepartment of Medicine, Division of Nephrology, Veterans Administration Palo Alto Health Care System and Stanford University, Palo Alto, CA cDepartment of Medicine, Division of Nephrology dWelch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD eDepartments of Medicine and Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY fDepartment of Medicine, Case Western University School of Medicine, Cleveland, OH gDepartment of Medicine, Zuckerberg San Francisco General Hospital, San Francisco.
    The uremic syndrome is attributed to progressive retention of compounds that, under normal conditions, are excreted by the healthy kidneys. p-cresol sulfate (PCS), a prototype protein-bound uremic retention solute, has been shown to exert toxic effects in vitro. Recent studies have identified relations between increased levels of PCS and indoxyl sulfate (IS) and adverse clinical outcomes in hemodialysis patients. Read More

    De novo thrombotic microangiopathy following simultaneous pancreas and kidney transplantation managed with eculizumab.
    Nephrology (Carlton) 2017 Feb;22 Suppl 1:23-27
    Department of Nephrology, Monash Health, Melbourne, Victoria, Australia.
    Thrombotic microangiopathy (TMA) is a well-recognised complication following transplantation, often due to an underlying genetic predisposition, medications or rejection. The use of eculizumab in these settings has been previously described, but its role still remains to be clarified. A 45-year-old man, with a history of type 1 diabetes mellitus and subsequent end-stage kidney failure, presented for a simultaneous pancreas-kidney transplant. Read More

    Acute PD: Evidence, Guidelines, and Controversies(☆).
    Semin Nephrol 2017 Jan;37(1):103-112
    Renal Unit, Greys Hospital, Pietermaritzburg, South Africa. Electronic address:
    Peritoneal dialysis (PD) may be a feasible, safe, and complementary alternative to hemodialysis not only in the chronic setting, but also in the acute setting. It previously was widely accepted for acute kidney injury (AKI) treatment, but its practice decreased in favor of other types of extracorporeal therapies. The interest in PD to manage AKI patients has been reignited and PD now frequently is used in developing countries because of its lower cost and minimal infrastructural requirements. Read More

    Hepatitis C and kidney disease: A narrative review.
    J Adv Res 2017 Mar 26;8(2):113-130. Epub 2016 Jul 26.
    The Cairo Kidney Center, Cairo, Egypt.
    Hepatitis-C (HCV) infection can induce kidney injury, mostly due to formation of immune-complexes and cryoglobulins, and possibly to a direct cytopathic effect. It may cause acute kidney injury (AKI) as a part of systemic vasculitis, and augments the risk of AKI due to other etiologies. It is responsible for mesangiocapillary or membranous glomerulonephritis, and accelerates the progression of chronic kidney disease due to other causes. Read More

    En-Bloc Transplant of the Liver, Kidney and Pancreas: Experience from a Latin American Transplant Center.
    Am J Case Rep 2017 Feb 2;18:114-118. Epub 2017 Feb 2.
    Abdominal Transplantation Surgery, Transplantation Unit, Centre for Clinical Research, Fundación Valle de Lili, Centre for Research on Advanced Surgery and Transplants (CICAT), Universidad Icesi, Cali, Valle del Cauca, Colombia.
    BACKGROUND En-bloc transplantation is a surgical procedure in which multiple organs are transplanted simultaneously. It has some similarities with multi-organ transplantation but offers certain advantages. This report highlights the experience of our interdisciplinary group regarding the treatment and follow-up of patients who received en-bloc transplantation, with the aim of encouraging the development of this surgical technique. Read More

    Changing Landscape for Peritoneal Dialysis: Optimizing Utilization.
    Semin Dial 2017 Mar 1;30(2):149-157. Epub 2017 Feb 1.
    Clinical Affairs, Home Modalities, DaVita Kidney Care, DaVita Inc, Denver, Colorado.
    The future growth of peritoneal dialysis (PD) will be directly linked to the shift in US healthcare to a value-based payment model due to PD's lower yearly cost, early survival advantage over in-center hemodialysis, and improved quality of life for patients treating their kidney disease in the home. Under this model, nephrology practices will need an increased focus on managing the transition from chronic kidney disease to end-stage renal disease (ESRD), providing patient education with the aim of accomplishing modality selection and access placement ahead of dialysis initiation. Physicians must expand their knowledge base in home therapies and work toward increased technique survival through implementation of specific practice initiatives that highlight PD catheter placement success, preservation of residual renal function, consideration of incremental PD, and competence in urgent start PD. Read More

    The Effect of Predialysis Fistula Attempt on Risk of All-Cause and Access-Related Death.
    J Am Soc Nephrol 2017 Feb 6;28(2):613-620. Epub 2016 Oct 6.
    Cumming School of Medicine.
    Whether the lower risk of mortality associated with arteriovenous fistula use in hemodialysis patients is due to the avoidance of catheters or if healthier patients are simply more likely to have fistulas placed is unknown. To provide clarification, we determined the proportion of access-related deaths in a retrospective cohort study of patients aged ≥18 years who initiated hemodialysis between 2004 and 2012 at five Canadian dialysis programs. A total of 3168 patients initiated dialysis at the participating centers; 2300 met our inclusion criteria. Read More

    Peritoneal dialysis is a reasonable option in patients with cardiovascular disease
.
    Clin Nephrol 2017 Mar;87 (2017)(3):111-116
    Introduction: Peritoneal dialysis (PD) has been proposed as a therapeutic option for patients with end-stage renal disease (ESRD) and cardiovascular (CV) disease. The study presented here aimed to compare incident PD patients with and without CV disease at baseline, in order to determine the impact of CV disease in the outcomes of long-term PD patients.

    Methods: This is a prospective cohort study performed at a single PD unit where 112 consecutive incident patients admitted to the PD program during 5 years were studied. Read More

    Risk factors for 30-day unplanned readmission following infrainguinal endovascular interventions.
    J Vasc Surg 2017 Feb;65(2):484-494.e3
    Division of Vascular and Endovascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass. Electronic address:
    Objective: Unplanned hospital readmissions following surgical interventions are associated with adverse events and contribute to increasing health care costs. Despite numerous studies defining risk factors following lower extremity bypass surgery, evidence regarding readmission after endovascular interventions is limited. This study aimed to identify predictors of 30-day unplanned readmission following infrainguinal endovascular interventions. Read More

    Contribution of volume overload to the arterial stiffness of hemodialysis patients.
    Ren Fail 2017 Nov;39(1):333-339
    d Department of Emergency Medicine , Medical University of Warsaw , Warsaw , Poland.
    Arterial stiffness is evaluated with the measurement of pulse wave velocity (PWV), while overhydration (OH) and nutritional status are evaluated with bioimpedance spectroscopy (BIS). In this study, we investigated the effect of a single dialysis session on arterial stiffness, hydration status, and laboratory parameters. The observational, cross-sectional, cohort study included 71 HD patients with mean age 64 ± 16 yrs. Read More

    Diet in chronic kidney disease in a Mediterranean African country.
    BMC Nephrol 2017 Jan 23;18(1):34. Epub 2017 Jan 23.
    Neprology Department Hedi Chaker Hospital, Sfax, Tunisia.
    Background: Mediterranean diet is characterized by low to moderate consumption of animal protein and high consumption of fruits, vegetables, bread, beans, nuts, seeds and other cereals. It has been associated with reduced risk of cardiovascular disease. However, it is not suitable for chronic kidney disease because of high potassium intake. Read More

    Spontaneous rupture of a caseous calcification of the mitral annulus in a hemodialysis patient.
    J Card Surg 2017 Feb 22;32(2):85-87. Epub 2017 Jan 22.
    Second Department of Surgery, Yamagata University Faculty of Medicine, Yamagata, Japan.
    We report a 56-year-old hemodialysis patient with a spontaneously ruptured caseous calcification of the mitral annulus resulting in multiple cerebral emboli. The mass was resected without replacing the mitral valve. The patient has remained symptom-free 3. Read More

    Intradialytic creatine supplementation: A scientific rationale for improving the health and quality of life of dialysis patients.
    Med Hypotheses 2017 Feb 7;99:1-14. Epub 2016 Dec 7.
    Nephrology Klinik Im Park, Zurich, Switzerland.
    The CK/PCr-system, with creatine (Cr) as an energy precursor, plays a crucial role in cellular physiology. In the kidney, as in other organs and cells with high and fluctuating energy requirements, energy-charged phospho-creatine (PCr) acts as an immediate high-energy source and energy buffer, and as an intracellular energy transport vehicle. A maximally filled total Cr (Cr plus PCr) pool is a prerequisite for optimal functioning of the body and its organs, and health. Read More

    Cardiovascular impact in patients undergoing maintenance hemodialysis: Clinical management considerations.
    Int J Cardiol 2017 Apr 4;232:12-23. Epub 2017 Jan 4.
    Kaufman Center for Heart Failure, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, United States. Electronic address:
    Patients undergoing maintenance hemodialysis develop both structural and functional cardiovascular abnormalities. Despite improvement of dialysis technology, cardiovascular mortality of this population remains high. The pathophysiological mechanisms of these changes are complex and not well understood. Read More

    Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial.
    JAMA 2017 01;317(2):156-164
    Stanford University, Stanford, California.
    Importance: Secondary hyperparathyroidism contributes to extraskeletal calcification and is associated with all-cause and cardiovascular mortality. Control is suboptimal in the majority of patients receiving hemodialysis. An intravenously (IV) administered calcimimetic could improve adherence and reduce adverse gastrointestinal effects. Read More

    Uncertainty, the Overbearing Lived Experience of the Elderly People Undergoing Hemodialysis: A Qualitative Study.
    Int J Community Based Nurs Midwifery 2017 Jan;5(1):13-21
    Department of Nephrology, Mazandaran University of Medical Sciences, Sari, Iran.
    Background: The chronic kidney disease is a major health concern. The number of the elderly people with chronic renal failure has increased across the world. Dialysis is an appropriate therapy for the elderly, but it involves certain challenges. Read More

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