77,527 results match your criteria Renal Failure Acute


Chemometric analysis of Amaranthus retroflexus in relation to livestock toxicity in southern Australia.

Phytochemistry 2019 Feb 15;161:1-10. Epub 2019 Feb 15.

Graham Centre for Agricultural Innovation (Charles Sturt University and NSW Department of Primary Industries), Wagga Wagga, NSW, 2650, Australia; Charles Sturt University, School of Agricultural and Wine Sciences, Wagga Wagga, NSW, 2678, Australia.

Amaranthus retroflexus L., an introduced invasive weed in southern Australia, has been associated with acute renal failure and/or mortality in a number of livestock species. While its leaves, flowers and stems are generally reported to contain high levels of nitrogen, few studies have fully characterised the chemical composition of A. Read More

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http://dx.doi.org/10.1016/j.phytochem.2019.01.016DOI Listing
February 2019

A Single-Center Retrospective Study of Acute Kidney Injury Incidence in Patients With Advanced Malignancies Treated With Antimitochondrial Targeted Drug.

Kidney Int Rep 2019 Feb 29;4(2):310-320. Epub 2018 Oct 29.

Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

Introduction: Mitochondrial dysfunction plays an important role in the pathophysiology of kidney disease. Inhibitors of mitochondrial metabolism are being developed for the treatment of solid organ and hematologic malignancies. We describe the incidence and clinical features of acute kidney injury (AKI) in patients treated with the antimitochondrial drug CPI-613. Read More

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http://dx.doi.org/10.1016/j.ekir.2018.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365364PMC
February 2019

Giant Gastroschisis with Complete Liver Herniation: A Case Report of Two Patients.

Case Rep Surg 2019 15;2019:4136214. Epub 2019 Jan 15.

Department of General Surgery, Boston Children's Hospital, 300 Longwood Ave, Fegan 3, Boston MA 20115, USA.

Introduction: There are no reported survivors of gastroschisis with complete liver herniation. We describe a case report of two patients, one of whom survived.

Case #1: The patient was born with gastroschisis and herniation of the entire liver. Read More

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http://dx.doi.org/10.1155/2019/4136214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350565PMC
January 2019

Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with Nivolumab.

Case Rep Nephrol 2019 15;2019:3614980. Epub 2019 Jan 15.

Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Immune-checkpoint-inhibitors (ICPIs) represent a novel class of immunotherapy against several malignancies. These agents are associated with several "immune-mediated" adverse effects, but the reported renal toxicity of ICPIs is less well defined. We present the case of a 60-year-old man with a history of non-small cell lung cancer, who developed acute kidney injury (AKI) approximately 3. Read More

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http://dx.doi.org/10.1155/2019/3614980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350541PMC
January 2019

Pharmacological interventions for the prevention of contrast-induced acute kidney injury in high-risk adult patients undergoing coronary angiography: a systematic review and meta-analysis of randomised controlled trials.

Open Heart 2019 25;6(1):e000864. Epub 2019 Jan 25.

Imperial College Trial Unit and Division of Surgery and Cancer, Imperial College London, St. Mary's Hospital, London, UK.

Objective: Quantify the efficacy of strategies to prevent contrast-induced acute kidney injury (CI-AKI) in high-risk patients undergoing coronary angiography (CAG) with or without percutaneous coronary intervention (PCI).

Background: CI-AKI remains a common problem. The renoprotective efficacy of existing pharmacological agents remains uncertain in high-risk populations. Read More

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http://dx.doi.org/10.1136/openhrt-2018-000864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350720PMC
January 2019

HO-1 concentrations 24 hours after cardiac surgery are associated with the incidence of acute kidney injury: a prospective cohort study.

Int J Nephrol Renovasc Dis 2019 23;12:9-18. Epub 2019 Jan 23.

Department of Cardiovascular Surgery, University Hospital Würzburg, Würzburg, Germany,

Background: Acute kidney injury (AKI) is a serious complication after cardiac surgery that is associated with increased mortality and morbidity. Heme oxygenase-1 (HO-1) is an enzyme synthesized in renal tubular cells as one of the most intense responses to oxidant stress linked with protective, anti-inflammatory properties. Yet, it is unknown if serum HO-1 induction following cardiac surgical procedure involving cardiopulmonary bypass (CPB) is associated with incidence and severity of AKI. Read More

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http://dx.doi.org/10.2147/IJNRD.S165308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350641PMC
January 2019

Serial assessment of spot urine sodium predicts effectiveness of decongestion and outcome in patients with acute heart failure.

Eur J Heart Fail 2019 Feb 17. Epub 2019 Feb 17.

Centre for Heart Diseases, Military Hospital, Wroclaw, Poland.

Aims: The clinical significance of the measurement of urine sodium concentration (UNa ) in response to loop diuretic administration in patients with acute heart failure (AHF) is still unsettled. We studied the association of serial measurements of spot UNa during the first 48 h of AHF treatment with the indices of decongestion, renal function, and prognosis.

Methods And Results: We enrolled 111 AHF patients, all of whom received intravenous furosemide on admission. Read More

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http://dx.doi.org/10.1002/ejhf.1428DOI Listing
February 2019

Bullous Pemphigoid with Atypical Skin Lesions and Acute Interstitial Nephritis: A Case Report and Focused Literature Review.

Am J Case Rep 2019 Feb 18;20:212-218. Epub 2019 Feb 18.

Department of Internal Medicine, Mount Sinai Hospital, Chicago, IL, USA.

BACKGROUND The hallmark of bullous pemphigoid (BP) is widespread tense blisters arising on normal or erythematous skin, often with marked pruritus, the diagnosis of which is confirmed by direct immunofluorescence (DIF). BP is an autoimmune process that can be induced, though rarely, by medications. Drug-induced BP often has atypical clinical presentation, which requires a good understanding of other dermatological conditions with similar presentations, in particular, bullous subtype of erythema multiforme. Read More

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http://dx.doi.org/10.12659/AJCR.911422DOI Listing
February 2019

Unilateral Versus Bilateral Antegrade Cerebral Perfusion: A Meta-Analysis of Comparative Studies.

Heart Lung Circ 2019 Feb 3. Epub 2019 Feb 3.

The Collaborative Research (CORE) Group International, Macquarie University, Sydney, NSW, Australia; Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, NSW, Australia.

Background: Antegrade cerebral perfusion (ACP) is an essential adjunct for prolonged hypothermic circulatory arrest (HCA) during aortic arch surgery. However, it has yet to be established whether ACP should be delivered unilaterally or bilaterally. The aim of the present meta-analysis is to investigate outcomes of unilateral ACP (uACP) compared to bilateral ACP (bACP) in comparative studies. Read More

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http://dx.doi.org/10.1016/j.hlc.2019.01.010DOI Listing
February 2019

Perfusion induced acute kidney injury: Critiques that do not roll off the tongues of thoracic surgeons.

J Thorac Cardiovasc Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, University of Kentucky, Lexington, Ky.

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http://dx.doi.org/10.1016/j.jtcvs.2018.12.095DOI Listing
February 2019

Validation of a methodology for neuro-urological and lumbosacral stimulation studies in domestic pigs: a humanlike animal model.

J Neurosurg Spine 2019 Feb 15:1-11. Epub 2019 Feb 15.

7Neurosurgery, Pellegrin Hospital, Bordeaux, Nouvelle Aquitaine; and.

OBJECTIVESpinal cord injuries (SCIs) result in loss of movement and sensory feedback, but also organ dysfunction. Nearly all patients with complete SCI lose bladder control and are prone to kidney failure if intermittent catheterization is not performed. Electrical stimulation of sacral spinal roots was initially considered to be a promising approach for restoring continence and micturition control, but many patients are discouraged by the need for surgical deafferentation as it could lead to a loss of sensory functions and reflexes. Read More

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http://dx.doi.org/10.3171/2018.11.SPINE18676DOI Listing
February 2019

Three-stage laparoscopic surgery in a morbidly obese patient with Hinchey III diverticulitis: a case report.

Surg Case Rep 2019 Feb 15;5(1):24. Epub 2019 Feb 15.

Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka 8-35-1, Kagoshima, 890-8520, Japan.

Background: Perforated diverticulitis with purulent peritonitis (Hinchey III diverticulitis) has traditionally been treated with a Hartmann's procedure in order to avoid the considerable postoperative morbidity and mortality associated with one-stage resection and primary anastomosis. Although there have been reports regarding laparoscopic lavage as the initial treatment of perforated Hinchey III diverticulitis, a formal treatment strategy has not been established yet. We performed a three-stage surgery, including laparoscopic lavage and drainage with diverting ileostomy (first stage), laparoscopic sigmoidectomy (second stage), and ileostomy closure (third stage) in a morbidly obese patient with Hinchey III diverticulitis. Read More

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http://dx.doi.org/10.1186/s40792-019-0588-7DOI Listing
February 2019

Diabetes Management in Older Adults With Chronic Kidney Disease.

Curr Diab Rep 2019 Feb 15;19(3):11. Epub 2019 Feb 15.

Department of Medicine, Division of Nephrology, Stanford University School of Medicine, Stanford, CA, USA.

Purpose Of Review: Older adults often live with chronic disease including diabetes and its complications. In this review, we examine the complexity and heterogeneity of older adults with diabetes and chronic kidney disease, explore the nuances in their diabetes-related monitoring, and discuss their best diabetes management.

Recent Findings: Although there remains an overall lack of studies in older adults with diabetes and chronic kidney disease, recent reports have highlighted their vulnerabilities. Read More

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http://dx.doi.org/10.1007/s11892-019-1128-3DOI Listing
February 2019

Single kidney transplantation from donors with acute kidney injury: A single-center experience.

Pediatr Transplant 2019 Feb 15:e13326. Epub 2019 Feb 15.

Department of Urology, West China Hospital, Sichuan University, Chengdu, China.

Introduction: Despite a severe shortage of organ supply, patients are reluctant to accept organs from deceased donors with AKI, let alone from pediatric AKI donors.

Methods: We assessed 70 patients who received kidneys from donors with AKI (10 with pediatric and 60 with adult donors) and 176 contemporaneous patients who received kidneys from non-AKI donors (41 with pediatric and 135 with adult donors) between March 2012 and February 2017 for retrospectively evaluating the clinical outcomes.

Results: AKI was defined and staging by the RIFLE criteria and pediatric-modified RIFLE criteria. Read More

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http://dx.doi.org/10.1111/petr.13326DOI Listing
February 2019

Mid-term prognostic impact of residual pulmonary congestion assessed by radiographic scoring in patients admitted for worsening heart failure.

Int J Cardiol 2019 Feb 8. Epub 2019 Feb 8.

Université de Lorraine, INSERM, Centre d'Investigations Cliniques 1433, CHRU de Nancy, Inserm U1116, Nancy, France; Department de Cardiologie, CHU de Nancy, Institut Lorrain du coeur et des vaisseaux, Nancy, France; INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN network, Nancy, France. Electronic address:

Aims: Pulmonary congestion is associated with poor prognosis following hospitalization for worsening heart failure (HF), although its quantification and optimal timing during HF hospitalization remains challenging. The aim of this study was to assess the prognostic value of radiographic pulmonary congestion at admission and discharge in patients with worsening HF.

Methods And Results: Clinical, echocardiographic, laboratory and chest X-ray data of 292 acute decompensated HF patients were retrospectively studied (follow-up 1 year). Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.01.091DOI Listing
February 2019

Metabolomics Approaches for the Diagnosis and Understanding of Kidney Diseases.

Metabolites 2019 Feb 14;9(2). Epub 2019 Feb 14.

Separation Science and Metabolomics Laboratory, Murdoch University, 90 South Street, Perth 6150, Australia.

Diseases of the kidney are difficult to diagnose and treat. This review summarises the definition, cause, epidemiology and treatment of some of these diseases including chronic kidney disease, diabetic nephropathy, acute kidney injury, kidney cancer, kidney transplantation and polycystic kidney diseases. Numerous studies have adopted a metabolomics approach to uncover new small molecule biomarkers of kidney diseases to improve specificity and sensitivity of diagnosis and to uncover biochemical mechanisms that may elucidate the cause and progression of these diseases. Read More

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http://dx.doi.org/10.3390/metabo9020034DOI Listing
February 2019

Association between Drug Use and In-Hospital Outcomes after Infrainguinal Bypass for Peripheral Arterial Occlusive Disease.

Ann Vasc Surg 2019 Feb 12. Epub 2019 Feb 12.

Johns Hopkins Bayview Vascular and Endovascular Research Center, Baltimore, MD; Department of Surgery, University of California San Diego, La Jolla, CA. Electronic address:

Objective: Drug abuse may affect lower extremity vessels due to ischemia following intra-arterial injections, vasospasm, arterial and venous pseudoaneurysms, arteriovenous fistulae, vasculitis and complicated abscesses. Little is known about the outcomes of Lower Extremity Bypass (LEB) for peripheral arteries disease (PAD) in patients with a history of drug abuse disorder. The aim of this study is to evaluate the outcomes of LEB in this patient population. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.12.070DOI Listing
February 2019

Polytetrafluoroethylene is a safe and effective interposition conduit for caval reconstruction after resection of primary leiomyosarcoma of the inferior vena cava.

Ann Vasc Surg 2019 Feb 12. Epub 2019 Feb 12.

Northwestern University Feinberg School of Medicine, Division of Vascular Surgery Chicago, IL. Electronic address:

Background: Primary leiomyosarcoma of the inferior vena cava (IVC) is a rare soft tissue sarcoma. Techniques for caval reconstruction after tumor resection vary widely. Our single-center experience serves as one of the largest reviews of caval reconstruction using polytetrafluoroethylene (PTFE) interposition grafts published in the past 10 years. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.12.068DOI Listing
February 2019

ERAP1 allotypes impact the epitope repertoire of virus-specific CD8 T cell responses in acute hepatitis C virus infection.

J Hepatol 2019 Feb 12. Epub 2019 Feb 12.

Department of Medicine II, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

Background & Aims: Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms are linked with human leukocyte antigen (HLA) class I-associated autoinflammatory disorders, including ankylosing spondylitis and Behçet's disease. Disease-associated ERAP1 allotypes exhibit distinct functional properties, but it remains unclear how differential peptide trimming in vivo affects the repertoire of epitopes presented to CD8 T cells. The aim of this study was to determine the impact of ERAP1 allotypes on the virus-specific CD8 T cell epitope repertoire in an HLA-B*27:05 individual with acute hepatitis C virus (HCV) infection. Read More

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http://dx.doi.org/10.1016/j.jhep.2019.01.034DOI Listing
February 2019

Identification of microRNA-mRNA networks involved in cisplatin-induced renal tubular epithelial cells injury.

Eur J Pharmacol 2019 Feb 12. Epub 2019 Feb 12.

Department of Nephrology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, 100730, China. Electronic address:

Cisplatin is a widely used chemotherapeutic drug that often causes acute kidney injury (AKI) in cancer patients. The contribution of miRNAs to the cisplatin-induced renal tubular epithelial cell injury remains largely unknown. Here we performed an integrative network analysis of miRNA and mRNA expression profiles to shed light into the underlying mechanism of cisplatin-induced renal tubular epithelial cell injury. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.02.015DOI Listing
February 2019
1 Read

Abatacept as rescue immunosuppression after calcineurin inhibitor treatment failure in renal transplantation.

Am J Transplant 2019 Feb 15. Epub 2019 Feb 15.

Emory Transplant Center, Atlanta, Georgia.

A majority of kidney transplant recipients receive calcineurin inhibitor (CNI)-based immunosuppression. However, some do not tolerate CNIs and require other immunosuppressive strategies. Until recently, alternative approaches have been associated with inferior outcomes, but recent methods have effectively utilized belatacept in CNI intolerant patients. Read More

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http://dx.doi.org/10.1111/ajt.15319DOI Listing
February 2019

Proteomics for clinical assessment of kidney disease.

Authors:
Alberto Ortiz

Proteomics Clin Appl 2019 Feb 15:e1900004. Epub 2019 Feb 15.

IIS-Fundacion Jimenez Diaz, School of Medicine, Universidad Autonoma de Madrid, Fundacion Renal Iñigo Alvarez de Toledo-IRSIN and REDINREN, Madrid, Spain.

Kidney disease is one of the fastest growing causes of death worldwide, disclosing an unmet clinical need for early diagnosis and optimized risk stratification that allows high risk patient selection for clinical trials and for more intensive nephroprotective interventions in the clinic. The current issue of PROTEOMICS - Clinical Applications contains four manuscripts that explore different aspects of clinical proteomics implementation in the context of acute kidney injury, chronic kidney disease and, more specifically, diabetic kidney disease, and kidney transplantation from a diagnostic and risk stratification point of view. Overall, the evidence discussed suggests that chronic kidney disease is an example where clinical proteomics has become a valuable tool ready for clinical implementation, expected to have a major impact in patient management. Read More

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http://dx.doi.org/10.1002/prca.201900004DOI Listing
February 2019

Acute kidney injury model established by systemic glutathione depletion in mice.

J Appl Toxicol 2019 Feb 15. Epub 2019 Feb 15.

Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Glutathione (GSH) is one of the most extensively studied tripeptides. The roles for GSH in redox signaling, detoxification of xenobiotics and antioxidant defense have been investigated. A drug-induced rhabdomyolysis mouse model was recently established in L-buthionine-(S,R)-sulfoximine (BSO; a GSH synthesis inhibitor)-treated normal mice by co-administration of antibacterial drug and statin. Read More

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http://doi.wiley.com/10.1002/jat.3780
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http://dx.doi.org/10.1002/jat.3780DOI Listing
February 2019
4 Reads

Renal Replacement Therapy in the ICU.

Crit Care Med 2019 Feb 13. Epub 2019 Feb 13.

Division of Nephrology, Department of Medicine, Cooper University Health Care, Cooper Medical School of Rowan University, Camden, NJ.

Objectives: The incidence of acute kidney injury in critically ill patients is increasing steeply. Acute kidney injury in this setting is associated with high morbidity and mortality. There is no doubt that renal replacement therapy for the most severe forms of acute kidney injury can be life saving, but there are a number of uncertainties about the optimal application of renal replacement therapy for patients with acute kidney injury. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003701DOI Listing
February 2019
1 Read

Near-drowning: new perspectives for human hypoxic acute kidney injury.

Nephrol Dial Transplant 2019 Feb 14. Epub 2019 Feb 14.

Department of Medicine D, Rambam Health Care Campus and Ruth & Bruce Rappaport Faculty of Medicine, Technion-IIT, Haifa, Israel.

Concepts regarding hypoxic acute kidney injury (AKI) are derived from widely used warm ischemia-reflow (WIR) models, characterized by extensive proximal tubular injury and associated with profound inflammation. However, there is ample clinical and experimental data indicating that hypoxic AKI may develop without total cessation of renal blood flow, with a different injury pattern that principally affects medullary thick limbs in the outer medulla. This injury pattern likely reflects an imbalance between blood and oxygen supply and oxygen expenditure, principally for tubular transport. Read More

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http://dx.doi.org/10.1093/ndt/gfz016DOI Listing
February 2019
1 Read

Association of Nonsteroidal Anti-inflammatory Drug Prescriptions With Kidney Disease Among Active Young and Middle-aged Adults.

JAMA Netw Open 2019 Feb 1;2(2):e187896. Epub 2019 Feb 1.

Division of Primary Care and Population Health, Department of Medicine, Stanford University School of Medicine, Stanford, California.

Importance: Concern about the renal effects of nonsteroidand al anti-inflammatory drugs (NSAIDs) among young, healthy adults has been limited, but more attention may be warranted given the prevalent use of these agents.

Objective: To test for associations between dispensed NSAIDs and incident acute kidney injury and chronic kidney disease while controlling for other risk factors.

Design, Setting, And Participants: This retrospective, longitudinal cohort study used deidentified medical and administrative data on 764 228 active-duty US Army soldiers serving between January 1, 2011, and December 31, 2014. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.7896DOI Listing
February 2019

The role of thoracic endovascular repair in elective, symptomatic and ruptured thoracic aortic diseases.

Eur J Cardiothorac Surg 2019 Feb 14. Epub 2019 Feb 14.

Department of Vascular Surgery, University Aortic Center of the Ludwig-Maximilian University Munich, Munich, Germany.

Objectives: Thoracic endovascular aortic repair (TEVAR) has emerged as a safe procedure in the treatment of a wide spectrum of descending thoracic aortic pathologies, with satisfactory results both in elective and urgent settings. We investigated the results of our elective, urgent and emergency TEVAR interventions.

Methods: A single-centre retrospective analysis of all consecutive patients undergoing TEVAR from 2010 to 2016 was performed. Read More

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http://dx.doi.org/10.1093/ejcts/ezy482DOI Listing
February 2019

Factors that impact kidney function during open and endovascular reconstruction of aortic aneurysms.

Cir Cir 2019 ;87(2):170-175

Dirección de Cirugía, Sección de Angiología, Cirugía Vascular y Terapia Endovascular, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México.

Background: To analyze the factors that influence the deterioration of postoperative renal function in patients undergoing open or endovascular aortic reconstruction, and the impact on survival.

Method: Retrospective review of patients who underwent invasive treatment was conducted. Demographics, laboratory data, clinical, intraoperative and postoperative variables were recorded; renal function was determined, Fisher's exact test was used to find associations and Kaplan Meier analysis to estimate survival. Read More

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http://dx.doi.org/10.24875/CIRU.18000448DOI Listing
January 2019

Evaluation of biomarkers of kidney injury following 4% succinylated gelatin and 6% hydroxyethyl starch 130/0.4 administration in a canine hemorrhagic shock model.

J Vet Emerg Crit Care (San Antonio) 2019 Feb 14. Epub 2019 Feb 14.

School of Veterinary and Life Sciences, Murdoch University, Perth, WA, Australia.

Objective: To investigate the association between synthetic colloids and biomarkers of acute kidney injury (AKI) in dogs with hemorrhagic shock.

Design: Experimental interventional study.

Setting: University. Read More

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http://dx.doi.org/10.1111/vec.12814DOI Listing
February 2019
1 Read

Urinary neutrophil gelatinase-associated lipocalin in dogs with stable or progressive kidney disease.

J Vet Intern Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota.

Background: Active kidney injury may play a role in chronic kidney disease (CKD) progression in dogs. Neutrophil gelatinase-associated lipocalin (NGAL), a novel tubular kidney injury biomarker, may help differentiate progressive CKD from stable CKD in dogs.

Objectives: To determine if urinary NGAL : creatinine ratio (UNCR) differentiates stable and progressive CKD in dogs. Read More

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http://dx.doi.org/10.1111/jvim.15428DOI Listing
February 2019

The yield and safety of screening colonoscopy in patients evaluated for liver transplantation.

Hepatology 2019 Feb 14. Epub 2019 Feb 14.

Department of Gastroenterology and Hepatology, Erasmus MC University Hospital, Rotterdam, Netherlands.

Colorectal cancer screening with colonoscopy is commonly used in candidate patients for liver transplantation. We initiated this study to define the risk-benefit ratio of performing screening colonoscopy in this population. A retrospective observational study of all consecutive patients undergoing colonoscopy during pre-liver transplantation screening between 2004-2017 was conducted. Read More

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http://dx.doi.org/10.1002/hep.30562DOI Listing
February 2019

Proenkephalin and prognosis in heart failure with preserved ejection fraction: a GREAT network study.

Clin Res Cardiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Cardiovascular Sciences, Clinical Sciences Wing, NIHR Leicester Biomedical Research Centre, Glenfield Hospital, University of Leicester, Leicester, LE3 9QP, UK.

Background: Proenkephalin (PENK), a stable endogenous opioid biomarker related to renal function, has prognostic utility in acute and chronic heart failure. We investigated the prognostic utility of PENK in heart failure with preserved ejection fraction (HFpEF), and its relationship to renal function, Body Mass Index (BMI), and imaging measures of diastolic dysfunction.

Methods: In this multicentre study, PENK was measured in 522 HFpEF patients (ejection fraction > 50%, 253 male, mean age 76. Read More

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http://dx.doi.org/10.1007/s00392-019-01424-yDOI Listing
February 2019

An atypical pneumonia.

Respirol Case Rep 2019 Apr 5;7(3):e00407. Epub 2019 Feb 5.

Department of Thoracic Medicine The Prince Charles Hospital Brisbane Australia.

We describe a patient with underlying HIV presenting with progressive respiratory distress and acute renal failure. A unifying diagnosis of microscopic polyangiitis was made. Following immunosuppression induction with plasma exchange and intravenous corticosteroid and subsequent maintenance immunosuppression with intravenous cyclophosphamide in conjunction with renal replacement therapy he achieved remission. Read More

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http://dx.doi.org/10.1002/rcr2.407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363593PMC

Computed Tomography with Intravenous Contrast Is Not Associated with Development of Acute Kidney Injury in Severely Injured Pediatric Patients.

Am Surg 2019 Jan;85(1):e1-e5

Data for the incidence of acute kidney injury (AKI) related to intravenous contrast administration in the pediatric trauma population are limited. Obtaining a creatinine value before elective CT scans is a relatively accepted standard of care. We sought to determine whether there was any significant difference in the incidence of AKI between severely injured patients who received IV contrast and those who did not. Read More

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January 2019
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Serum indoxyl sulfate is associated with mortality in hospital-acquired acute kidney injury: a prospective cohort study.

BMC Nephrol 2019 Feb 14;20(1):57. Epub 2019 Feb 14.

Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, 639 Zhizaoju Road, Shanghai, 200011, China.

Background: Protein-bound uremic toxins are associated with poor outcomes in patients with chronic kidney disease. The aim of this study is to investigate the relationship between indoxyl sulfate (IS), a protein-bound solute, and 90-day mortality in patients with acute kidney injury.

Methods: Adults with hospital-acquired AKI (HA-AKI) were enrolled in this prospective cohort study between 2014 and 2015, according to the KDIGO creatinine criteria. Read More

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http://dx.doi.org/10.1186/s12882-019-1238-9DOI Listing
February 2019
1 Read

Identifying on admission patients likely to develop acute kidney injury in hospital.

BMC Nephrol 2019 Feb 14;20(1):56. Epub 2019 Feb 14.

Research, Development, and Innovation, Royal Cornwall Hospitals NHS Trust, Truro, TR1 3HD, UK.

Background: The incidence of Acute Kidney Injury (AKI) continues to increase in the UK, with associated mortality rates remaining significant. Approximately one fifth of hospital admissions are associated with AKI and approximately a third of patients with AKI in hospital develop AKI during their time in hospital. A fifth of these cases are considered avoidable. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-019-1237-xDOI Listing
February 2019
2 Reads

Postoperative Acute Kidney Injury in Young Adults with Congenital Heart Disease.

Ann Thorac Surg 2019 Feb 11. Epub 2019 Feb 11.

Department of Critical Care Medicine, The Center for Critical Care Nephrology, 3347 Forbes Avenue, Suite 220, Pittsburgh, PA 15213.

Background: There is an increasing number of young adults living with congenital heart disease (CHD). The goal of this study was to ascertain the frequency of acute kidney injury (AKI) as well as the risk factors and outcomes associated with AKI in young adults with CHD after a surgical procedure.

Methods: This was a single center retrospective cohort study including all patients 18-40 years of age with a diagnosis of CHD admitted to a quaternary care children's hospital cardiac intensive care unit postoperatively from 2004-2015. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.017DOI Listing
February 2019
1 Read

Renal and Vascular Effects of Kallikrein Inhibition in a Model of Lonomia obliqua Venom-Induced Acute Kidney Injury.

PLoS Negl Trop Dis 2019 Feb 14;13(2):e0007197. Epub 2019 Feb 14.

Laboratório de Bioquímica Farmacológica, Centro de Pesquisa Experimental (CPE), Hospital de Clínicas de Porto Alegre (HCPA-UFRGS), Porto Alegre, RS, Brazil.

Background: Lonomia obliqua venom is nephrotoxic and acute kidney injury (AKI) is the main cause of death among envenomed victims. Mechanism underlying L. obliqua-induced AKI involves renal hypoperfusion, inflammation, tubular necrosis and loss of glomerular filtration and tubular reabsorption capacities. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007197DOI Listing
February 2019

Risk of subsequent health disorders among living kidney donors.

Medicine (Baltimore) 2019 Feb;98(7):e14494

Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University.

Few studies have investigated the risk of physiological sequelae in living kidney donors (KDs). We conducted a population-based cohort study using the National Health Insurance Research Database of Taiwan, which covers more than 99% of citizens.We comprehensively investigated the risk of medical disorders after kidney donation in living KDs using a maximum follow-up of 13 years. Read More

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http://Insights.ovid.com/crossref?an=00005792-201902150-0005
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http://dx.doi.org/10.1097/MD.0000000000014494DOI Listing
February 2019
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The effects of perioperative intravenous fluid administration strategy on renal outcomes in patients undergoing cardiovascular surgery: An observational study.

Medicine (Baltimore) 2019 Feb;98(7):e14383

Department of Anesthesiology and Pain Medicine.

We assessed whether perioperative fluid management with balanced solutions and a limited volume of hydroxyethyl starch (renal-protective fluid management [RPF] strategy) could improve renal outcomes after cardiovascular surgery.For this retrospective observational study, we evaluated 2613 patients who underwent cardiovascular surgery from January 1, 2010 to December 31, 2013. The control group were given intravenous fluids with saline-based solutions and unlimited volumes of hydroxyethyl starch solutions and the RPF group were given intravenous fluids with RPF. Read More

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http://dx.doi.org/10.1097/MD.0000000000014383DOI Listing
February 2019

The triad of diabetes ketoacidosis, hypertriglyceridemia and acute pancreatitis. How does it affect mortality and morbidity?: A 10-year analysis of the National Inpatient Sample.

Medicine (Baltimore) 2019 Feb;98(7):e14378

Gastroenterology and Hepatology Department, Digestive Disease Institute.

The triad of acute pancreatitis (AP) coexisting with diabetes ketoacidosis (DKA) and hypertriglyceridemia (HTG) has been reported, but no impact on mortality has been found to date. We aim to assess if patients with this triad are at a higher inpatient mortality compared to patients with acute pancreatitis only.Retrospective cohort. Read More

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http://dx.doi.org/10.1097/MD.0000000000014378DOI Listing
February 2019
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Inhalation versus intravenous anesthesia for adults undergoing heart valve surgery: a systematic review and meta-analysis.

Minerva Anestesiol 2019 Feb 13. Epub 2019 Feb 13.

Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, PR China -

Introduction: Many studies have found that volatile anesthetics are associated with improved clinical outcomes for adults undergoing coronary artery bypass grafting. However, the effect of volatile anesthetics for adults after heart valve surgery has been unclear. So we conducted a meta-analysis of randomized controlled trials (RCTs) to explore whether the choice of an anesthetic regimen might influence patients' outcomes after valve surgery. Read More

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http://dx.doi.org/10.23736/S0375-9393.19.13377-9DOI Listing
February 2019

Kynurenine 3-monooxygenase is a critical regulator of renal ischemia-reperfusion injury.

Exp Mol Med 2019 Feb 13;51(2):15. Epub 2019 Feb 13.

Centre for Inflammation Research, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.

Acute kidney injury (AKI) following ischemia-reperfusion injury (IRI) has a high mortality and lacks specific therapies. Here, we report that mice lacking kynurenine 3-monooxygenase (KMO) activity (Kmo mice) are protected against AKI after renal IRI. We show that KMO is highly expressed in the kidney and exerts major metabolic control over the biologically active kynurenine metabolites 3-hydroxykynurenine, kynurenic acid, and downstream metabolites. Read More

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http://dx.doi.org/10.1038/s12276-019-0210-xDOI Listing
February 2019
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Computed Tomography with Intravenous Contrast Is Not Associated with Development of Acute Kidney Injury in Severely Injured Pediatric Patients.

Am Surg 2019 Jan;85(1):e1-e5

Data for the incidence of acute kidney injury (AKI) related to intravenous contrast administration in the pediatric trauma population are limited. Obtaining a creatinine value before elective CT scans is a relatively accepted standard of care. We sought to determine whether there was any significant difference in the incidence of AKI between severely injured patients who received IV contrast and those who did not. Read More

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January 2019
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Angiopoietin 1 influences ischemic reperfusion renal injury via modulating endothelium survival and regeneration.

Mol Med 2019 Feb 13;25(1). Epub 2019 Feb 13.

Department of Internal Medicine, National Taiwan University Hospital, No. 7, Jhong-Shan South Road, Taipei, 100, Taiwan.

Background: Damage to the endothelium due to ischemia reperfusion injury (IRI) leads to a disruption of the microvasculature, which could be influenced by angiopoietin 1 via its effects on endothelium. We investigated the physiological and therapeutic roles of angiopoietin 1 in renal IRI using angiopoietin 1 knockout and over-expression mice.

Methods: Renal IRI was induced by clamping the right renal artery seven days after left uninephrectomy for 25 min followed by reperfusion. Read More

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http://dx.doi.org/10.1186/s10020-019-0072-7DOI Listing
February 2019

Design and Production of a Recombinant Hybrid Toxin to Raise Protective Antibodies Against Spider Venom.

Toxins (Basel) 2019 Feb 12;11(2). Epub 2019 Feb 12.

Laboratory of Immunopathology, Butantan Institute, 05503-900 São Paulo, Brazil.

Human accidents with spiders of the genus Loxosceles are an important health problem affecting thousands of people worldwide. Patients evolve to severe local injuries and, in many cases, to systemic disturbances as acute renal failure, in which cases antivenoms are considered to be the most effective treatment. However, for antivenom production, the extraction of the venom used in the immunization process is laborious and the yield is very low. Read More

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http://dx.doi.org/10.3390/toxins11020108DOI Listing
February 2019

Molecular Mechanisms of Colistin-Induced Nephrotoxicity.

Molecules 2019 Feb 12;24(3). Epub 2019 Feb 12.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, 8006 Zurich, Switzerland.

The emergence of multidrug resistant (MDR) infections and the shortage of new therapeutic options have made colistin, a polymyxin antibiotic, the main option for the treatment of MDR Gram-negative bacterial infections in the last decade. However, the rapid onset of renal damage often prevents the achievement of optimal therapeutic doses and/or forces the physicians to interrupt the therapy, increasing the risk of drug resistance. The proper management of colistin-induced nephrotoxicity remains challenging, mostly because the investigation of the cellular and molecular pharmacology of this drug, off the market for decades, has been largely neglected. Read More

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http://dx.doi.org/10.3390/molecules24030653DOI Listing
February 2019

The association between heat stroke and subsequent cardiovascular diseases.

PLoS One 2019 13;14(2):e0211386. Epub 2019 Feb 13.

Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background: Recent studies have indicated that several critical illnesses are associated with an increased risk of cardiovascular diseases (CVDs). Nonetheless, studies of the association between heat-related illnesses (HRIs) and subsequent CVDs are still limited. We sought to evaluate whether heat stroke (HS) was associated with an increased CVD incidence. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211386PLOS
February 2019
2 Reads

Retraction.

Authors:

J Ultrasound Med 2019 Mar 23;38(3):823. Epub 2019 Jan 23.

Qin, H., Wu, H., Chen, Y. Read More

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http://dx.doi.org/10.1002/jum.14946DOI Listing

Burden, access, and disparities in kidney disease.

Pediatr Nephrol 2019 Feb 13. Epub 2019 Feb 13.

Nephrology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.

Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world, as does its detection and treatment. In many settings, rates of kidney disease and the provision of its care are defined by socio-economic, cultural, and political factors leading to significant disparities. Read More

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http://dx.doi.org/10.1007/s00467-019-4197-2DOI Listing
February 2019