99,181 results match your criteria Renal Failure Acute


NCOA2 coordinates with the transcriptional KAT2B-NF-κB partner to trigger inflammation response in acute kidney injury.

Gene 2022 May 18:146583. Epub 2022 May 18.

Department of Nephrology, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang 330006, Jiangxi, China. Electronic address:

Dysregulation of multiple genes is an important risk factor for acute kidney injury (AKI). Numerous genes, such as proinflammatory cytokines, intracellular cell adhesion molecules (ICAMs), and nitric oxide synthases (NOSs), are implicated in AKI pathogenesis. However, the molecular mechanisms involved in the dysregulation of these genes are still obscure. Read More

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Surgical outcomes of pulmonary valve infective endocarditis: A US population-based analysis.

Int J Cardiol 2022 May 18. Epub 2022 May 18.

Division of Cardiothoracic Surgery, Department of Surgery, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA; Division of Cardiac Surgery, NorthShore University HealthSystem, Chicago, IL, USA. Electronic address:

Background: Pulmonary valve infective endocarditis (PVIE) represents a rare subset of right-sided IE. This study aimed to evaluate the population-level surgical outcomes of PVIE in the United States.

Methods: We performed a retrospective observational study using the 2002-2017 National Inpatient Sample database. Read More

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Presence of comorbidities alters management and worsens outcome of patients with acute respiratory distress syndrome: insights from the LUNG SAFE study.

Ann Intensive Care 2022 May 21;12(1):42. Epub 2022 May 21.

School of Medicine, National University of Ireland Galway, Galway, Ireland.

Background: The impact of underlying comorbidities on the clinical presentation, management and outcomes in patients with ARDS is poorly understood and deserves further investigation.

Objectives: We examined these issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study.

Methods: In this secondary analysis of the patient cohort enrolled in the LUNG SAFE study, our primary objective was to determine the frequency, and impact of comorbidities on the management and ICU survival of patients with ARDS. Read More

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Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study.

Intensive Care Med 2022 May 21. Epub 2022 May 21.

Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072, Milan, Italy.

Purpose: To accommodate the unprecedented number of critically ill patients with pneumonia caused by coronavirus disease 2019 (COVID-19) expansion of the capacity of intensive care unit (ICU) to clinical areas not previously used for critical care was necessary. We describe the global burden of COVID-19 admissions and the clinical and organizational characteristics associated with outcomes in critically ill COVID-19 patients.

Methods: Multicenter, international, point prevalence study, including adult patients with SARS-CoV-2 infection confirmed by polymerase chain reaction (PCR) and a diagnosis of COVID-19 admitted to ICU between February 15th and May 15th, 2020. Read More

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Acute kidney injury and functional outcomes after partial nephrectomy.

Int J Urol 2022 May 20. Epub 2022 May 20.

Department of Urology, Onze-Lieve-Vrouwziekenhuis, Aalst.

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Correlation between perioperative parecoxib use and postoperative acute kidney injury in patients undergoing radical mastectomy: a retrospective cohort analysis.

BMC Anesthesiol 2022 May 20;22(1):155. Epub 2022 May 20.

The Department of Pain, The Fourth Affiliated Hospital of Harbin Medical University, 37 Yiyuan Street, Nangang District, Harbin, Heilongjiang, China.

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely prescribed drugs worldwide. However, the effect of NSAIDS on postoperative renal function is still unclear. Few studies have assessed the effects of parecoxib on renal function. Read More

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Predictors of kidney complications and analysis of hypertension in children with allogeneic hematopoietic stem cell transplantation.

Pediatr Nephrol 2022 May 20. Epub 2022 May 20.

Department of Pediatrics, Division of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara, Turkey, 06100.

Background: This study aimed to determine incidence of kidney complications in pediatric allogeneic hematopoietic stem cell transplantation (HSCT) patients.

Methods: Pediatric allogeneic HSCT patients were included. Post-transplantation urinary system complications were collected from medical records and glomerular filtration rates at last visit compared with clinical parameters. Read More

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Clinical and pathological characteristics of patients with acute kidney injury in Japan in whom kidney biopsy was performed: a cross-sectional analysis of the Japan Renal Biopsy Registry (J‑RBR).

Clin Exp Nephrol 2022 May 20. Epub 2022 May 20.

Department of Pathology, Keio University School of Medicine, Tokyo, Japan.

Introduction: Acute kidney injury (AKI) is a worldwide concern and it leads to a poor prognosis or end-stage kidney disease. The purpose of this study was to clarify the characteristics of patients with AKI in whom kidney biopsy was performed using data of the Japan Renal Biopsy Registry (J-RBR).

Methods: We screened 38,351 cases that were registered in the J-RBR from 2007 to 2018. Read More

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Intraoperative hypotension is associated with persistent acute kidney disease after noncardiac surgery: a multicentre cohort study.

Br J Anaesth 2022 May 17. Epub 2022 May 17.

Department of Anesthesia, Indiana University School of Medicine, Indianapolis, IN, USA; Anesthesiology Services, Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA.

Background: Whilst intraoperative hypotension is associated with postoperative acute kidney injury (AKI), the link between intraoperative hypotension and acute kidney disease (AKD), defined as continuing renal dysfunction for up to 3 months after exposure, has not yet been studied.

Methods: We conducted a retrospective multicentre cohort study using data from noncardiac, non-obstetric surgery extracted from a US electronic health records database. Primary outcome was the association between intraoperative hypotension, at three MAP thresholds (≤75, ≤65, and ≤55 mm Hg), and the following two AKD subtypes: (i) persistent (initial AKI incidence within 7 days of surgery, with continuation between 8 and 90 days post-surgery) and (ii) delayed (renal impairment without AKI within 7 days, with AKI occurring between 8 and 90 days post-surgery). Read More

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Mechanical Circulatory Support: Primer for Consultant Specialists.

Clin J Am Soc Nephrol 2022 May 20. Epub 2022 May 20.

Department of Anesthesiology, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York.

Mechanical life support therapies exist in many forms to temporarily replace the function of vital organs. Generally speaking, these tools are supportive therapy to allow for organ recovery but, at times, require transition to long-term mechanical support. This review will examine nonrenal extracorporeal life support for cardiac and pulmonary support as well as other mechanical circulatory support options. Read More

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Midterm Follow-up of the Transatrial-to-Left-Ventricle Cannulation for Acute Type A Dissection.

Ann Thorac Surg 2022 May 17. Epub 2022 May 17.

Department of Cardiac and Vascular Surgery, University Medical Center, Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Background: It is still controversial as to which cannulation-strategy for acute-type-A-aortic-dissection (AAD) is optimal. Antegrade-perfusion to diminish further organ-mal-perfusion and -ischemia are preferable.

Methods: We retrospectively analyzed a total of 420 patients who underwent AAD-surgery from January 2001 to December 2019. Read More

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Dose-dependent renoprotective impact of Lactoferrin against glycerol-induced rhabdomyolysis and acute kidney injury.

Life Sci 2022 May 16:120646. Epub 2022 May 16.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt.

Acute kidney injury (AKI) is a clinical disorder with a serious impact on the quality of patients' lives. Considering its increased worldwide prevalence, investigating novel therapeutic approaches for the management of AKI has been inevitable. Lactoferrin (LF), a glycoprotein belonging to the transferrin family, is known to play an important role in regulating iron homeostasis. Read More

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An audit of a decade of acute peritoneal dialysis in children with acute kidney injury: A single-center experience.

Niger J Clin Pract 2022 May;25(5):690-694

Department of Child Health, University of Benin Teaching Hospital, Benin City, Nigeria.

Background: Acute peritoneal dialysis (PD) is the modality of choice to manage children with acute kidney injury (AKI). However, its use remains underutilized, despite the unquestionable advantages.

Aims: This study, therefore, aimed to audit the complications, outcomes, and challenges encountered with PD as well as indications for PD and causes of AKI among under-5 children that had PD in a Nigerian tertiary hospital over a decade. Read More

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Efficacy and Safety of Postdilation for a Self-Expanding Transcatheter Heart Valve.

J Invasive Cardiol 2022 May 19. Epub 2022 May 19.

Kerckhoff Heart Center, Department of Cardiology, 61231 Bad Nauheim, Germany.

Background: Data are lacking regarding the outcomes of balloon postdilation (BPD) for the Acurate neo and neo2 devices. The aim of this study was to assess the impact of BPD in a large, single-center cohort of patients treated with the Acurate platform.

Methods: For this retrospective analysis, we included all patients with severe aortic stenosis who underwent transfemoral transcatheter aortic valve replacement (TAVR) with the Acurate neo or neo2 prosthesis at our institution. Read More

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Distribution of Nicotinamide Mononucleotide After Intravenous Injection in Normal and Ischemic Stroke Mice.

Curr Pharm Biotechnol 2022 May 18. Epub 2022 May 18.

Department of Pharmacology, Second Military Medical University / Naval Medical University, 325 Guo He Road, Shanghai 200433, China.

Objective: This study determined for the first time the distribution of intravenous nicotinamide mononucleotide (NMN) and its metabolite nicotinamide adenine dinucleotide (NAD) in normal and ischemic stroke mice, examined therapeutic effect of NMN on ischemic brain infarction, and evaluated acute toxicity of NMN after intravenous injection of NMN.

Methods: NMN and NAD was were determined using ultra-high performance liquid chromatography tandem mass spectrometry in biological samples from mice with or without middle cerebral artery occlusion (MCAO) at different time points post intravenous NMN injection (300 mg/kg). Brain infarction was evaluated 24 h post MCAO. Read More

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An update on the functional roles of long non‑coding RNAs in ischemic injury (Review).

Int J Mol Med 2022 Jul 20;50(1). Epub 2022 May 20.

Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Clinical Research Center for Ophthalmic Disease, Nanchang, Jiangxi 330006, P.R. China.

Ischemic injuries result from ischemia and hypoxia in cells. Tissues and organs receive an insufficient supply of nutrients and accumulate metabolic waste, which leads to the development of inflammation, fibrosis and a series of other issues. Ischemic injuries in the brain, heart, kidneys, lungs and other organs can cause severe adverse effects. Read More

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Association of Cancer Diagnosis and Therapeutic Stage With Mortality in Pediatric Patients With COVID-19, Prospective Multicenter Cohort Study From Latin America.

Front Pediatr 2022 3;10:885633. Epub 2022 May 3.

Pediatric Critical Care Division, Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, TX, United States.

Background: Children with cancer are at risk of critical disease and mortality from COVID-19 infection. In this study, we describe the clinical characteristics of pediatric patients with cancer and COVID-19 from multiple Latin American centers and risk factors associated with mortality in this population.

Methods: This study is a multicenter, prospective cohort study conducted at 12 hospitals from 6 Latin American countries (Argentina, Bolivia, Colombia, Ecuador, Honduras and Peru) from April to November 2021. Read More

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Preventive Effect of Collagen Peptides from on Acute Kidney Injury through Attenuation of Oxidative Stress and Inflammation.

Oxid Med Cell Longev 2022 10;2022:8186838. Epub 2022 May 10.

Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China.

The protective effect of collagen peptide from (Amp) on acute kidney injury (AKI) in mice and its mechanism were explored. The results showed that Amp-fed could effectively improve the renal mass index and histopathological morphology. The levels of serum creatinine and urea nitrogen decreased significantly, while the antioxidant enzyme catalase (CAT) and superoxide dismutase (SOD) increased significantly in Amp-fed groups. Read More

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Extracorporeal membrane oxygenation support and total thyroidectomy in patients with refractory thyroid storm: case series and literature review.

J Surg Case Rep 2022 May 17;2022(5):rjac131. Epub 2022 May 17.

Department of Surgery, Trauma and Vascular Surgery, Hamad Medical Corporation, Qatar.

Thyroid storm (TS) is a rare but life-threatening complication of hyperthyroidism in which multiorgan failure (MOF) is the most common cause of death. Early diagnosis and treatment of TS are challenging. We presented two cases with refractory TS complicated with arrhythmia, cardiac arrest, cardiogenic shock and MOF and were not responding to medical treatment, therapeutic plasma exchange or continuous renal replacement therapy. Read More

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Light Chain Cast Nephropathy in Multiple Myeloma: Prevalence, Impact and Management Challenges.

Int J Nephrol Renovasc Dis 2022 13;15:173-183. Epub 2022 May 13.

Division of Nephrology, Department of Internal Medicine, Sant'Andrea University Hospital, Rome, Italy.

"Cast nephropathy" (CN) is a pathological feature of myeloma kidney, also seen to a lesser extent in the context of severe nephrotic syndrome from non-haematological diseases. The name relates to obstruction of distal tubules by "casts" of luminal proteins concentrated by intensive water reabsorption resulting from dehydration or high-dose diuretics. Filtered proteins form complexes with endogenous tubular Tamm-Horsfall glycoprotein. Read More

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The Usefulness of Assessing Heart Rate Variability in Patients with Acute Myocardial Infarction (HeaRt-V-AMI).

Sensors (Basel) 2022 May 7;22(9). Epub 2022 May 7.

Faculty of Medicine, University of Medicine and Pharmacy "Grigore T Popa", 700115 Iasi, Romania.

Background: Heart rate variability (HRV) could have independent and critical prognostic values in patients admitted for ST segment elevation myocardial infarction (STEMI). There are limited data in the literature regarding HRV assessment in STEMI setting. Thus, we aim to investigate the potential correlations between HRV and adverse outcomes in a contemporary cohort of patients presenting with STEMI undergoing primary percutaneous coronary intervention (PCI). Read More

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Intraoperative Hypotension Prediction Model Based on Systematic Feature Engineering and Machine Learning.

Sensors (Basel) 2022 Apr 19;22(9). Epub 2022 Apr 19.

Bigdata Engineering Department, SCH Media Labs, Soonchunhyang University, Asan 31538, Korea.

Arterial hypotension is associated with incidence of postoperative complications, such as myocardial infarction or acute kidney injury. Little research has been conducted for the real-time prediction of hypotension, even though many studies have been performed to investigate the factors which affect hypotension events. This forecasting problem is quite challenging compared to diagnosis that detects high-risk patients at current. Read More

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Protective effect of bee pollen in acute kidney injury, proteinuria, and crystalluria induced by ethylene glycol ingestion in rats.

Sci Rep 2022 May 19;12(1):8351. Epub 2022 May 19.

Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health, and Quality of Life (SNAMOPEQ), Department of Biology, Faculty of Sciences Dhar Mehraz, Sidi Mohamed Ben Abdellah University, 30000, Fez, Morocco.

Oxidative stress plays a role in hyperoxaluria-induced kidney injury and crystallization. Bee pollen is a hive product with a high content of antioxidants. The antioxidant content and protective effect of bee pollen extract (BPE) against ethylene glycol (EG) induced crystalluria, and acute kidney injury (AKI) were investigated. Read More

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Medicare Bundled Payment Policy on Anemia Care, Major Adverse Cardiovascular Events, and Mortality among Adults Undergoing Hemodialysis.

Clin J Am Soc Nephrol 2022 May 19. Epub 2022 May 19.

Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana.

Background And Objectives: In 2011, the Centers for Medicare & Medicaid Services implemented bundling of all services for patients receiving dialysis, including erythropoietin-stimulating agents use, and the Food and Drug Administration recommended conservative erythropoietin-stimulating agent dosing.

Design, Setting, Participants, & Measurements: This retrospective cohort study investigated anemia care and clinical outcomes before and after the Centers for Medicare & Medicaid Services bundled payment and the revised Food and Drug Administration-recommended erythropoietin-stimulating agent labeling for Medicare-insured adults receiving hemodialysis using data from the United States Renal Data System from January 1, 2006 to December 31, 2016. Clinical outcomes included major adverse cardiovascular event (stroke, acute myocardial infarction, and all-cause mortality), cardiovascular mortality, and heart failure. Read More

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Inpatient hospitalisation and mortality rate trends from 2004 to 2014 in the USA: a propensity score-matched case-control study of hyperkalaemia.

BMJ Open 2022 May 19;12(5):e059324. Epub 2022 May 19.

Cardiorenal Society of America, Phoenix, Arizona, USA.

Objective: To study the trends of hyperkalaemia in USA inpatient hospitalisation records with heart failure (HF), chronic kidney disease (CKD), acute kidney injury (AKI) and/or type II diabetes mellitus (T2DM) from 2004 to 2014 with respect to prevalence and inpatient mortality.

Design: Observational cross-sectional and propensity score-matched case-control study.

Setting: The National Inpatient Sample (representing up to 97% of inpatient hospital discharge records in the USA) from 2004 to 2014 PARTICIPANTS: 120 513 483 (±2 312 391) adult inpatient hospitalisation records with HF, CKD/end-stage renal disease (ESRD), AKI and/or T2DM. Read More

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Cocaine-induced rhabdomyolysis and compartment syndrome.

BMJ Case Rep 2022 May 19;15(5). Epub 2022 May 19.

Pulmonary, Critical Care, and Sleep Medicine, Hartford Hospital, Hartford, Connecticut, USA.

A man in his 30s with a history of cocaine and intranasal heroin use presented to the emergency department with severe leg pain and weakness. Physical examination findings were significant for tachycardia, absence of dorsalis pedis pulses, tense and painful calf muscles along with absence of plantar reflexes in bilateral lower extremities. Laboratory investigations were significant for positive urinary drug screen for cocaine, severe rhabdomyolysis and acute kidney injury. Read More

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Acute interstitial nephritis after COVID-19 vaccination.

BMJ Case Rep 2022 May 19;15(5). Epub 2022 May 19.

Renal Medicine, Hull and East Yorkshire Hospitals NHS Trust, Hull, UK.

A woman in her 70s presented to the hospital being generally unwell 8 days following the first dose of the AstraZeneca COVID-19 vaccination. She was in stage III acute kidney injury (AKI) with hyperkalaemia and metabolic acidosis. Urinalysis showed haematoproteinuria. Read More

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A novel small molecule Hsp90 inhibitor, C-316-1, attenuates acute kidney injury by suppressing RIPK1-mediated inflammation and necroptosis.

Int Immunopharmacol 2022 May 16;108:108849. Epub 2022 May 16.

Department of Nephropathy, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, PR China; Center for Scientific Research of Anhui Medical University, Hefei, Anhui 230022, PR China. Electronic address:

Acute kidney injury (AKI) is marked by a fast deterioration of the kidney function that may be caused by a variety of factors. Recently, although our group found that PPBICA alleviated programmed cell death in AKI, poor water solubility limited its bioavailability. In this research, we screened a series of derivatives and found that C-316-1 had the best suppressive effect on preventing necroptosis and inflammation in cisplatin- and ischemia/reperfusion-induced AKI in vitro and in vivo with lower toxicity and better water solubility. Read More

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