78,484 results match your criteria Renal Failure Acute


Sepsis-Associated Acute Kidney Injury: A Problem Deserving of New Solutions.

Nephron 2019 Apr 24:1-5. Epub 2019 Apr 24.

Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Sepsis-associated acute kidney injury (S-AKI) significantly worsens patient prognosis, and recent evidence suggests that the injury process begins early and may be sustained by therapies used to treat the sepsis (e.g., fluids resuscitation, antibiotics). Read More

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https://www.karger.com/Article/FullText/500167
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http://dx.doi.org/10.1159/000500167DOI Listing
April 2019
1 Read

Post-Streptococcal Glomerulonephritis in Two Patients Following Deceased Donor Kidney Transplant.

Am J Case Rep 2019 Apr 24;20:587-591. Epub 2019 Apr 24.

Piedmont Transplant Institute, Piedmont Hospital, Atlanta, GA, USA.

BACKGROUND Post-streptococcal glomerulonephritis (PSGN) is a well-known cause of renal injury. This disease is caused by a prior infection with specific nephritogenic strains of group A beta-hemolytic streptococcus resulting in formation of immune complexes in the glomeruli. Clinical presentation can range from asymptomatic, microscopic hematuria to the nephritic syndrome which is defined by red to brown urine, nephrotic range proteinuria, edema, hypertension, and acute kidney injury. Read More

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http://dx.doi.org/10.12659/AJCR.914304DOI Listing

Association of Duration and Type of Surgical Prophylaxis With Antimicrobial-Associated Adverse Events.

JAMA Surg 2019 Apr 24. Epub 2019 Apr 24.

Department of Medicine, VA Boston Healthcare System, Boston, Massachusetts.

Importance: The benefits of antimicrobial prophylaxis are limited to the first 24 hours postoperatively. Little is known about the harms associated with continuing antimicrobial prophylaxis after skin closure.

Objective: To characterize the association of type and duration of prophylaxis with surgical site infection (SSI), acute kidney injury (AKI), and Clostridium difficile infection. Read More

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http://archsurg.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamasurg.2019.0569DOI Listing
April 2019
1 Read

Alpha-Tocopherol and contrast-induced nephropathy: a meta-analysis of randomized controlled trials.

Int J Vitam Nutr Res 2019 Apr 24:1-9. Epub 2019 Apr 24.

8 Diabetology, Azienda Ospedaliero-Universitaria Careggi and University of Florence, Florence, Italy.

Contrast-induced nephropathy (CIN) is a relevant cause of acute renal dysfunction and is associated with an increased morbidity and mortality. Purpose: Verify the effect of α-tocopherol pre-treatment on CIN prevention in subjects with chronic kidney disease. A Medline/Embase and clinicaltrials. Read More

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https://econtent.hogrefe.com/doi/10.1024/0300-9831/a000573
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http://dx.doi.org/10.1024/0300-9831/a000573DOI Listing
April 2019
1 Read

Post-reperfusion plasma endothelial activation markers are associated with acute kidney injury after lung transplantation.

Am J Transplant 2019 Apr 24. Epub 2019 Apr 24.

Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Acute kidney injury (AKI) is common after lung transplantation, but molecular markers remain poorly studied. The endothelial activation markers soluble thrombomodulin (sTM), protein C, and plasminogen activator inhibitor-1 (PAI-1) are implicated in kidney microcirculatory injury in animal models of AKI. We tested the association of 6-hour post-reperfusion plasma levels of these markers with post-transplant AKI severity in patients enrolled in the Lung Transplant Outcomes Group prospective cohort study at the University of Pennsylvania during two eras: 2004-06 (n=61) and 2013-15 (n=67). Read More

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http://dx.doi.org/10.1111/ajt.15402DOI Listing

Outcomes of Liver Transplantation for Acute Fatty Liver Disease of Pregnancy.

Am J Transplant 2019 Apr 24. Epub 2019 Apr 24.

University of California, San Francisco, San Francisco, California.

Acute fatty liver of pregnancy (AFLP) often resolves after pregnancy delivery but can progress to acute liver failure necessitating liver transplantation. We performed a retrospective review of the national Scientific Registry of Transplant Recipients (SRTR) data to identify all women in the United States undergoing liver transplantation (LT) for acute liver failure (ALF) from AFLP from 1991 to 2015, and compared to outcomes in women of childbearing age undergoing transplant for ALF from acetaminophen and ALF from other etiologies. Women with AFLP were likely to be on life support at time of LT and had high rates of renal dysfunction (median Cr 2. Read More

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http://dx.doi.org/10.1111/ajt.15401DOI Listing

Regulation of Fn14 stability by SCF during septic acute kidney injury.

Am J Physiol Renal Physiol 2019 Apr 24. Epub 2019 Apr 24.

Intensive Care Unit, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, China.

Acute kidney injury (AKI) initiated by sepsis remains a thorny problem despite recent advancements in its clinical management. Having been found to be activated during AKI, Fn14 may be a potential therapeutic target due to its involvement in the molecular basis of injury. Here we report that LPS induces apoptosis of tubular MCT cells mediated by Fn14, for which simultaneous TLR4 activation is required. Read More

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http://dx.doi.org/10.1152/ajprenal.00627.2018DOI Listing

Inhibiting fibronectin polymerization alleviates kidney injury due to ischemia/reperfusion.

Am J Physiol Renal Physiol 2019 Apr 24. Epub 2019 Apr 24.

Heart institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, United States.

Fibrosis is a common feature of chronic kidney disease; however, no clinical therapies effectively target the progression of fibrosis. Inhibiting fibronectin polymerization with the small peptide pUR4 attenuates fibrosis in the liver and heart. Here, we show that pUR4 decreases renal fibrosis and tissue remodeling using a clinically relevant model of kidney injury, unilateral ischemia/reperfusion. Read More

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http://dx.doi.org/10.1152/ajprenal.00117.2019DOI Listing

Endophthalmitis after Cataract Surgery in Korea: A Nationwide Study Evaluating Incidence and Risk Factors in a Korean Population.

Yonsei Med J 2019 May;60(5):467-473

Department of Ophthalmology, Yonsei University Wonju College of Medicine, Wonju, Korea.

Purpose: To assess the nationwide rate of acute postoperative endophthalmitis (APE) after cataract extraction in Korea and to evaluate potential risk factors thereof.

Materials And Methods: Nationwide insurance claims data from July 2014 to June 2017 were reviewed. All patients with phacoemulsification or extracapsular/intracapsular cataract extraction were included. Read More

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http://dx.doi.org/10.3349/ymj.2019.60.5.467DOI Listing

Incidence and risk factors for acute kidney injury following autologous stem cell transplantation for multiple myeloma.

Cancer Med 2019 Apr 23. Epub 2019 Apr 23.

Nephrology Department, Fundeni Clinical Institute, Bucharest, Romania.

Acute kidney injury (AKI) is a common complication after allogeneic stem cell transplantation; however, its incidence and outcome in patients transplanted for multiple myeloma (MM) is unknown. We evaluated the incidence, severity, and risk factors for AKI within the first 30 days after autologous stem cell transplantation (ASCT) for MM. We prospectively followed 185 consecutive patients with MM, without chronic renal replacement therapy, who underwent ASCT; 12. Read More

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http://dx.doi.org/10.1002/cam4.2187DOI Listing

Causes of late transplant failure in cyclosporine-treated kidney allograft recipients.

Clin Exp Nephrol 2019 Apr 23. Epub 2019 Apr 23.

Renal Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: There is little information about very long-term outcomes of kidney allograft recipients exposed to calcineurin inhibitors.

Methods: In this single-centre retrospective study with 20-year follow-up, we analyzed data from 644 patients who underwent primary renal transplantation between 1983 and 1993. Participants were treated with a cyclosporine-based immunosuppressive scheme and had allograft function at 1 year. Read More

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http://link.springer.com/10.1007/s10157-019-01740-7
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http://dx.doi.org/10.1007/s10157-019-01740-7DOI Listing
April 2019
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Deserved attention for acute kidney injury after major trauma.

Intensive Care Med 2019 Apr 23. Epub 2019 Apr 23.

Renal Research Group Ullevål, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

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http://link.springer.com/10.1007/s00134-019-05609-x
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http://dx.doi.org/10.1007/s00134-019-05609-xDOI Listing
April 2019
1 Read

[Kidney function in contrast media-enhanced imaging].

Radiologe 2019 Apr 23. Epub 2019 Apr 23.

Klinik für Nephrologie, Universitätsklinikum Essen, Universität Duisburg Essen, Hufelandstr. 55, 45147, Essen, Deutschland.

Background: The potential adverse reactions to contrast media-enhanced imaging regularly offer challenges in decision-making for nephrologists and radiologists.

Objective: The clinical pictures of contrast media-induced acute kidney injury (CI-AKI) and nephrogenic systemic fibrosis (NSF) were evaluated, which are both caused by contrast media and closely linked to the kidney function.

Material And Methods: The literature in PubMed and Medline was searched for the terms "kidney function" and "contrast media" and complemented by our own experiences. Read More

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http://dx.doi.org/10.1007/s00117-019-0529-2DOI Listing

Determining the Incidence of Acute Kidney Injury Using the RIFLE Criteria in the Medical Intensive Care Unit in a Tertiary Care Hospital Setting in Pakistan.

Cureus 2019 Feb 13;11(2):e4071. Epub 2019 Feb 13.

Internal Medicine, Shifa International Hospital, Islamabad, PAK.

Background Acute kidney injury (AKI) is a frequently encountered clinical condition in hospitalized patients, particularly those admitted to intensive care units (ICU). AKI has its systemic sequelae and contributes to the morbidity of underlying diseases. Methods This descriptive case series aimed to determine the frequency of acute kidney injury in critically ill patients admitted to the ICU at Shifa International Hospital, Islamabad, according to the RIFLE (risk, injury, failure, loss, and end-stage) criteria. Read More

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http://dx.doi.org/10.7759/cureus.4071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464139PMC
February 2019

Bilateral Renal Infarction Secondary to Hypertrophic Cardiomyopathy.

Cureus 2019 Feb 11;11(2):e4046. Epub 2019 Feb 11.

Internal Medicine, Medstar Union Memorial Hospital, Baltimore, USA.

Bilateral renal infarction is a rare phenomenon which can be difficult to diagnose because the symptoms may often mimic renal calculi, infection, muscle inflammation, genital diseases, myocardial infarction, or ischemia. We present the case of a 55-year-old male patient who presented with non-radiating, left-sided flank pain associated with nausea and vomiting. A computed tomography (CT) scan of the abdomen and pelvis with contrast demonstrated bilateral renal infarction. Read More

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http://dx.doi.org/10.7759/cureus.4046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464458PMC
February 2019

Study of Delayed Antibiotic in Pediatric Febrile Immunocompromised Patients and Adverse Events.

Hosp Pediatr 2019 Apr 23. Epub 2019 Apr 23.

Division of Emergency Medicine and

Objectives: Bone marrow transplant (BMT) patients or patients receiving chemotherapy for oncologic diagnoses are at risk for sepsis. The association of time to antibiotics (TTA) with outcomes when adjusting for severity of illness has not been evaluated in the pediatric febrile immunocompromised (FI) population. We evaluated the association of TTA with adverse events in a cohort of FI patients presenting to our pediatric emergency department. Read More

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http://dx.doi.org/10.1542/hpeds.2018-0192DOI Listing

Post-contrast acute kidney injury in cancer patients.

Nefrologia 2019 Apr 20. Epub 2019 Apr 20.

Servicio de Radiodiagnóstico, Hospital Clínic, Barcelona, España.

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http://dx.doi.org/10.1016/j.nefro.2019.02.001DOI Listing

Retrograde Inferior Vena caval Perfusion for Total Aortic arch Replacement Surgery (RIVP-TARS): study protocol for a multicenter, randomized controlled trial.

Trials 2019 Apr 24;20(1):232. Epub 2019 Apr 24.

Department of Anesthesiology, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, Sichuan Province, China.

Background: During total aortic arch replacement surgery (TARS) for patients with acute type A aortic dissection, the organs in the lower body, such as the viscera and spinal cord, are at risk of ischemia even when antegrade cerebral perfusion (ACP) is performed. Combining ACP with retrograde inferior vena caval perfusion (RIVP) during TARS may improve outcomes by providing the lower body with oxygenated blood.

Methods: This study is designed as a multicenter, computer-generated, randomized controlled, assessor-blind, parallel-group study with a superiority framework in patients scheduled for TARS. Read More

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http://dx.doi.org/10.1186/s13063-019-3319-2DOI Listing

The incidence of acute kidney injury following cardiac arrest and cardiopulmonary resuscitation in a rat model.

Ren Fail 2019 Nov;41(1):278-283

a Department of Critical Care Medicine , Second Affiliated Hospital of Guangxi Medical University , Nanning , P.R. China.

Objective: In the current study, we investigated the incidence of acute kidney injury (AKI) induced by cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) and whether such an AKI can recover spontaneously in rats.

Methods: We used transesophageal alternating current stimulation to establish 7 min of CA rat model followed by conventional CPR. The experimental rats were randomly divided into three groups (n = 20 per group) according to the different time points after restoration spontaneous circulation (ROSC): the ROSC 24 h, ROSC 48 h, and ROSC 72 h group. Read More

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https://www.tandfonline.com/doi/full/10.1080/0886022X.2019.1
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http://dx.doi.org/10.1080/0886022X.2019.1596819DOI Listing
November 2019
1 Read

A Novel Multi-Biomarker Assay for Non-Invasive Quantitative Monitoring of Kidney Injury.

J Clin Med 2019 Apr 12;8(4). Epub 2019 Apr 12.

KIT Bio, 665 3rd Street, San Francisco, CA 94107, USA.

The current standard of care measures for kidney function, proteinuria, and serum creatinine (SCr) are poor predictors of early-stage kidney disease. Measures that can detect chronic kidney disease in its earlier stages are needed to enable therapeutic intervention and reduce adverse outcomes of chronic kidney disease. We have developed the Kidney Injury Test (KIT) and a novel KIT Score based on the composite measurement and validation of multiple biomarkers across a unique set of 397 urine samples. Read More

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http://dx.doi.org/10.3390/jcm8040499DOI Listing

Spontaneous Tumor Lysis Syndrome in Childhood T cell Acute Lymphoblastic Leukemia.

Oman Med J 2013 Nov;28(6):e063

Department of Laboratory Oncology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

We report two cases that presented with unexplained acute renal failure and hyperuricemia and were subsequently diagnosed with T-cell acute lymphoblastic leukemia. The patients improved with conservative therapy without the need for dialysis. Case 1 is the youngest case of acute lymphoblastic leukemia with spontaneous tumor lysis syndrome reported to date, and Case 2 presented with spontaneous tumor lysis syndrome without hyperleukocytosis. Read More

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http://dx.doi.org/10.5001/omj.2013.132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458442PMC
November 2013

Delayed Surgical Management of Type A Intramural Hematoma Is Not Associated with Worse Outcomes Than Emergent Operation.

Heart Surg Forum 2019 Mar 4;22(2):E103-E106. Epub 2019 Mar 4.

Division of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Objectives: Management of acute aortic intramural hematomas (IMHs) involving the ascending aorta and root remains controversial. Some series have suggested that delaying operative intervention beyond the first 24-hours may be beneficial.

Methods: A retrospective single-institution analysis was performed to identify patients presenting with type A IMH. Read More

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http://dx.doi.org/10.1532/hsf.2289DOI Listing

Safety and efficacy of eculizumab for the prevention of antibody-mediated rejection after deceased-donor kidney transplantation in patients with preformed donor-specific antibodies.

Am J Transplant 2019 Apr 23. Epub 2019 Apr 23.

Formerly Alexion Pharmaceuticals, Boston, Massachusetts.

The presence of preformed donor-specific antibodies (DSAs) in transplant recipients increases risk of acute antibody-mediated rejection (AMR). Results of an open-label, single-arm trial to evaluate safety and efficacy of eculizumab in preventing acute AMR in recipients of deceased-donor kidney transplants with preformed DSAs are reported. Participants received eculizumab as follows: 1200 mg immediately before reperfusion, 900 mg on posttransplantation days 1, 7, 14, 21 and 28, and 1200 mg at weeks 5, 7 and 9. Read More

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http://dx.doi.org/10.1111/ajt.15397DOI Listing

Fatal diffuse pulmonary fat microemboli following reperfusion in liver transplantation with the use of marginal steatotic allografts.

Am J Transplant 2019 Apr 23. Epub 2019 Apr 23.

Department of Surgery, Division of Transplant Surgery, Mayo Clinic Arizona, Phoenix, Arizona.

Organ shortage is a major cause of delayed liver transplantation and increased wait list time. The level of donor steatosis is a significant determinant in organ selection. Scarcity of organs has led some programs to expand their acceptable criteria for the percentage of steatosis. Read More

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http://dx.doi.org/10.1111/ajt.15399DOI Listing

Contrast enhancement ultrasound of renal perfusion in dogs with acute kidney injury.

J Small Anim Pract 2019 Apr 22. Epub 2019 Apr 22.

Department of Veterinary Sciences, University of Pisa - Via Livornese, 56122, Pisa, Italy.

Objective: To evaluate the efficacy of contrast-enhanced ultrasound to assess changes in renal perfusion in dogs with acute kidney injury.

Materials And Methods: The left kidney of each dog in two groups was examined using contrast-enhanced ultrasound: Group A consisted of 16 healthy dogs and Group B consisted of 12 dogs with acute kidney injury.

Results: All dogs in Group A showed the same sequence of wash-in and wash-out. Read More

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http://dx.doi.org/10.1111/jsap.13001DOI Listing

Postinfectious Acute Glomerulonephritis in Renal Transplantation: An Emergent Aetiology of Renal Allograft Loss.

Case Rep Transplant 2019 18;2019:7438254. Epub 2019 Mar 18.

Department of Nephrology and Renal Transplantation, Hospital Clínic, University of Barcelona, IDIBAPS, Barcelona, Spain.

Despite the high incidence of posttransplant infections, postinfectious acute glomerulonephritis (PIAGN) in renal allograft is a rare entity, without effective treatment and a bad prognosis. We describe two cases of PIAGN: the first one was developed 2 years after kidney transplantation, secondary to bacteremia with presence of extracapillary proliferation in biopsy. The patient was treated with methylprednisolone and plasma exchanges without response, remaining dialysis dependent. Read More

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http://dx.doi.org/10.1155/2019/7438254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442439PMC

Does Interhospital Transfer Influence the Outcomes of Patients Receiving Surgery for Acute Type A Aortic Dissection? Type A Aortic Dissection: Is Transfer Hazardous or Beneficial?

Emerg Med Int 2019 18;2019:5692083. Epub 2019 Mar 18.

Division of Thoracic and Cardiovascular Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi and Chang Gung University College of Medicine, Taoyuan, Taiwan.

Introduction: The progression of acute type A aortic dissection may cause immediate death, such that, in the event of its diagnosis, emergency surgery is indicated. Relatedly, an interhospital transfer may prolong the time from diagnosis to surgery. This study therefore investigated how interhospital transfers impact surgical outcomes for acute type A aortic dissection. Read More

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https://www.hindawi.com/journals/emi/2019/5692083/
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http://dx.doi.org/10.1155/2019/5692083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442438PMC
March 2019
4 Reads

Vascular repair after firearm injury is associated with increased morbidity and mortality.

J Vasc Surg 2019 May;69(5):1524-1531.e1

Center for Clinical Translational Epidemiology and Comparative Effectiveness Research, Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, Mass. Electronic address:

Objective: Firearm injuries have high morbidity and mortality. Presentation of injuries requiring concurrent vascular repair and its outcomes are unclear. Our study's objective was to characterize the injury details and to assess the associated mortality and morbidity after vascular repair. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07415214183223
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http://dx.doi.org/10.1016/j.jvs.2018.07.081DOI Listing
May 2019
1 Read

Are Clostridium difficile toxins nephrotoxic?

Authors:
Nevio Cimolai

Med Hypotheses 2019 May 5;126:4-8. Epub 2019 Mar 5.

Department of Pathology and Laboratory Medicine, Faculty of Medicine, The University of British Columbia, Canada; Department of Pathology and Laboratory Medicine, Children's and Women's Health Centre of British Columbia, 4480 Oak Street, Vancouver, B.C. V6H3V4, Canada. Electronic address:

Clostridium difficile-associated disease (CDAD) occurs along a spectrum from simple uncomplicated enteritis to a multi-system disease which may include nephropathy. Pathology is attributed to bacterial toxins, but it is unclear if the latter are directly nephrotoxic. Anecdotes of renal disease from human biopsy findings suggest a variation of histopathologies, but data are relatively limited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03069877193014
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http://dx.doi.org/10.1016/j.mehy.2019.03.002DOI Listing
May 2019
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Atypical Hemolytic Uremic Syndrome Presenting as Acute Heart Failure-A Rare Presentation: Diagnosis Supported by Skin Biopsy.

J Investig Med High Impact Case Rep 2019 Jan-Dec;7:2324709619842905

2 Westchester Medical Center, Valhalla, NY, USA.

Atypical hemolytic uremic syndrome (aHUS) is a rare disorder of uncontrolled complement activation that manifests classically as anemia, thrombocytopenia, and renal failure, although extrarenal manifestations are observed in 20% of the patient most of which involving central nervous system, with relatively rare involvement of the heart. In this article, we report the case of a 24-year-old male with no history of heart disease presenting with acute systolic heart failure along with microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Given his presentation of thrombotic microangiopathy (TMA), along with laboratory results significant for low haptoglobin, platelets, hemoglobin, C3, C4, CH50, and normal ADAMTS13 levels, with no diarrhea and negative STEC polymerase chain reaction in stool, aHUS diagnosis was established with strong clinical suspicion, and immediate initiation of treatment was advised. Read More

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http://dx.doi.org/10.1177/2324709619842905DOI Listing

Thirty-Day Readmission Risk Model for Older Adults Hospitalized With Acute Myocardial Infarction.

Circ Cardiovasc Qual Outcomes 2019 May;12(5):e005320

Leon H. Charney Division of Cardiology, Department of Medicine; Division of Healthcare Delivery Science, Department of Population Health, New York University School of Medicine (J.A.D.).

Background: Early readmissions among older adults hospitalized for acute myocardial infarction (AMI) are costly and difficult to predict. Aging-related functional impairments may inform risk prediction but are unavailable in most studies. Our objective was to, therefore, develop and validate an AMI readmission risk model for older patients who considered functional impairments and was suitable for use before hospital discharge. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.118.005
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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005320DOI Listing
May 2019
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Road Map for Opioid Management in the Inpatient Setting: A Structured Approach to Opioid Selection and Titration.

MedEdPORTAL 2016 Sep 28;12:10470. Epub 2016 Sep 28.

Assistant Dean of Faculty Development and Curriculum, Winthrop University Hospital Campus, Stony Brook University School of Medicine.

Introduction: Effective pain management is a major challenge of medicine as patients with acute and chronic pain conditions require careful evaluation and treatment. Despite required pain management education in postgraduate training, effective pain management is often not achieved in the hospital setting. For example, the Accreditation Council for Graduate Medical Education in 2007 required internal medicine residencies to include instruction on pain management. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464480PMC
September 2016

Endovascular treatment of an external iliac artery dissection causing early renal graft dysfunction.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiology Postgraduate Institute of Medical Education and Research, Chandigarh-160012, India.

Vascular complications such as renal artery or renal vein thrombosis and laceration, and iliac artery dissection are rarely encountered following renal transplantation. A timely management of these vascular complications is important to prevent ischemic injury of a transplanted kidney. We hereby report a 60-year-old male who had acute renal dysfunction due to iatrogenic left external iliac artery dissection, following renal transplantation. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.12.108DOI Listing

Risk Factors and Outcomes for Sepsis after Appendectomy in Adults.

Surg Infect (Larchmt) 2019 Apr 20. Epub 2019 Apr 20.

Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, New York.

Sepsis is an uncommon occurrence after appendectomy, but the morbidity and mortality of patients who develop sepsis after appendectomy remains exceedingly high. The purpose of this study is to identify risk factors and adverse post-operative outcomes associated with sepsis after appendectomy in adults. The American College of Surgery National Surgical Quality Improvement Program participant user database was queried from 2012 to 2015. Read More

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https://www.liebertpub.com/doi/10.1089/sur.2019.003
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http://dx.doi.org/10.1089/sur.2019.003DOI Listing
April 2019
2 Reads

The efficacy of renal replacement therapy strategies for septic-acute kidney injury: A PRISMA-compliant network meta-analysis.

Medicine (Baltimore) 2019 Apr;98(16):e15257

Department of Critical Care Medicine, Anqing Municipal Hospital, Anqing, Anhui, China.

Background: Renal replacement therapy (RRT) is the main treatment for patients with sepsis-induced acute kidney injury (SAKI). However, the choice of RRT strategy remains controversial.

Objective: This study assessed the effectiveness of RRT variants in SAKI patients by a network meta-analysis. Read More

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http://dx.doi.org/10.1097/MD.0000000000015257DOI Listing

New-onset atrial fibrillation in patients with acute coronary syndrome may be associated with worse prognosis and future heart failure.

J Arrhythm 2019 Apr 24;35(2):182-189. Epub 2019 Jan 24.

Division of Cardiology Department of Internal Medicine Memorial Heart Center Iwate Medical University Morioka Iwate Japan.

Background: The purpose of this study was to evaluate the prognostic value of atrial fibrillation (AF) in patients with acute coronary syndrome (ACS).

Methods: A total 648 of consecutive ACS patients were divided into non-AF and all-AF groups. The all-AF group was further subdivided into new-onset AF and pre-existing AF groups. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/joa3.12154
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http://dx.doi.org/10.1002/joa3.12154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457477PMC
April 2019
1 Read

Evaluation of C-reactive protein and its kinetics as a prognostic indicator in canine leptospirosis.

J Small Anim Pract 2019 Apr 22. Epub 2019 Apr 22.

Division of Small Animal Internal Medicine, Department of Clinical Veterinary Medicine, Vetsuisse Faculty University of Bern, Bern, 3001, Switzerland.

Objective: To evaluate C-reactive protein at presentation and during hospitalisation in dogs with acute kidney injury resulting from leptospirosis to compare C-reactive protein at presentation in dogs with acute kidney injury of different aetiology and to study its correlation with markers of inflammation, azotaemia and survival.

Materials And Methods: Prospective observational study of 41 dogs with acute kidney injury secondary to leptospirosis and 15 control dogs with acute kidney injury of different aetiology. C-reactive protein was measured at presentation in both groups and daily for 7 days in a subgroup of 28 dogs with leptospirosis. Read More

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http://dx.doi.org/10.1111/jsap.13004DOI Listing

Severe quetiapine voluntary overdose successfully treated with a new hemoperfusion sorbent.

Int J Artif Organs 2019 Apr 22:391398819837686. Epub 2019 Apr 22.

2 Nephrology, Dialysis and Transplantation Unit, Azienda Ospedaliera-Universitaria di Bologna, Bologna, Italy.

Quetiapine overdose, although rare, is mainly linked with tachycardia, QTc-interval prolongation, somnolence, coma, hyperglycemia, and eventually hepatotoxicity and myocarditis. Extracorporeal techniques for quetiapine removal might be helpful, but only a few cases are reported in the literature. We here describe the case of a 27-year-old healthy woman, admitted to our Intensive Care Unit after voluntary quetiapine intake and successfully treated with CytoSorb hemoperfusion in combination with continuous renal replacement therapy (CRRT), in order to accelerate quetiapine elimination. Read More

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http://dx.doi.org/10.1177/0391398819837686DOI Listing

Lipopolysaccharide in systemic circulation induces activation of inflammatory response and oxidative stress in cardiorenal syndrome type 1.

J Nephrol 2019 Apr 20. Epub 2019 Apr 20.

Department of Nephrology, Dialysis and Transplantation, St Bortolo Hospital, International Renal Research Institute Vicenza, Via Rodolfi, 37, 36100, Vicenza, Italy.

Background: Cardiorenal syndrome type 1 (CRS type 1) is characterized by a rapid worsening of cardiac function leading to acute kidney injury. In this study, we evaluate the role of lipopolysaccharide (LPS) and various inflammatory markers in the developing acute kidney injury (AKI) in acute heart failure (AHF) patients.

Methods: We enrolled 31 AHF patients and 20 CRS type 1 (the cause of AKI was presumed to be related to cardiac dysfunction) and 17 healthy volunteers without AHF, AKI or CKD, as control group (CTR). Read More

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http://dx.doi.org/10.1007/s40620-019-00613-2DOI Listing

Epidemiology of acute kidney injury among paediatric patients after repair of anomalous origin of the left coronary artery from the pulmonary artery.

Eur J Cardiothorac Surg 2019 Apr 21. Epub 2019 Apr 21.

Department of Anesthesiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

Objectives: Acute kidney injury (AKI) is a prevalent complication after the surgical repair of paediatric cardiac defects and is associated with poor outcomes. Insufficient renal perfusion secondary to severe myocardial dysfunction in neonates is most likely an independent risk factor in patients undergoing repair for anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA). We retrospectively investigated the epidemiology and outcomes of children with ALCAPA who developed AKI after repair. Read More

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https://academic.oup.com/ejcts/advance-article/doi/10.1093/e
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http://dx.doi.org/10.1093/ejcts/ezz090DOI Listing
April 2019
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Long-term outcomes of urinary tract infection (UTI) in Childhood (LUCI): protocol for an electronic record-linked cohort study.

BMJ Open 2019 Apr 20;9(4):e024210. Epub 2019 Apr 20.

Division of Population Medicine, School of Medicine, Wales Centre for Primary and Emergency Care Research (PRIME Centre Wales), Cardiff University, Cardiff, UK.

Introduction: Current guidelines advise the prompt diagnosis and treatment of urinary tract infection (UTI) in children to improve both short and longer term outcomes. However, the risk of long-term complications following childhood UTI is unclear.UTI is relatively common but difficult to diagnose in children as symptoms are non-specific. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02421
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http://dx.doi.org/10.1136/bmjopen-2018-024210DOI Listing
April 2019
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Reversible uraemic encephalopathy.

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Neurology, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1136/bcr-2018-228261DOI Listing

Protective effects of Rhizoma smilacis glabrae extracts on potassium oxonate- and monosodium urate-induced hyperuricemia and gout in mice.

Phytomedicine 2018 Nov 24;59:152772. Epub 2018 Nov 24.

Orthopedic Department, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, People's Republic of China. Electronic address:

Background: Rhizoma smilacis glabrae (RSG, tufuling) has been widely used in traditional Chinese medicine for deoxidation, dampness relief, and easing joint movement. The chemical composition of RSG has been systematically confirmed, and some of its compounds have been revealed to possess antioxidant, anti-inflammatory, immunomodulatory, hypouricemic, and hepatoprotective effects.

Purpose: We aimed to clarify whether a RSG extract attenuates hyperuricemia, paw edema, and renal injury in mice with potassium oxonate (PO)- and monosodium urate (MSU)-induced chronic hyperuricemia and gout. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09447113183058
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http://dx.doi.org/10.1016/j.phymed.2018.11.032DOI Listing
November 2018
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Risk of contrast-induced nephropathy in patients undergoing complex percutaneous coronary intervention.

Int J Cardiol 2019 Apr 14. Epub 2019 Apr 14.

Interventional Cardiology Division, Cardio-Thoracic-Vascular Department, San Raffaele Scientific Institute, Milan, Italy.

Background: Complex percutaneous coronary intervention (PCI) is associated with increased procedural challenges and high contrast load. We aimed to evaluate the association between complex PCI and contrast-induced nephropathy (CIN).

Methods: This single-center retrospective study included all-comers undergoing PCI between January 2012 and December 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01675273193147
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http://dx.doi.org/10.1016/j.ijcard.2019.04.043DOI Listing
April 2019
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Strategies that improve renal medullary oxygenation during experimental cardiopulmonary bypass may mitigate postoperative acute kidney injury.

Kidney Int 2019 Mar 15. Epub 2019 Mar 15.

Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Physiology, Monash University, Melbourne, Victoria, Australia. Electronic address:

Renal medullary hypoxia may contribute to cardiac surgery-associated acute kidney injury (AKI). However, the effects of cardiopulmonary bypass (CPB) on medullary oxygenation are poorly understood. Here we tested whether CPB causes medullary hypoxia and whether medullary oxygenation during CPB can be improved by increasing pump flow or mean arterial pressure (MAP). Read More

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http://dx.doi.org/10.1016/j.kint.2019.01.032DOI Listing

Regulated necrosis in kidney ischemia-reperfusion injury.

Kidney Int 2019 Mar 7. Epub 2019 Mar 7.

Immunology Research Centre, St. Vincent's Hospital Melbourne, Fitzroy, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia. Electronic address:

Ischemia-reperfusion injury (IRI) is the outcome of an inflammatory process that is triggered when an organ undergoes a transient reduction or cessation of blood flow, followed by re-establishment of perfusion. In the clinical setting, IRI contributes to significant acute kidney injury, patient morbidity and mortality, and adverse outcomes in transplantation. Tubular cell death by necrosis and apoptosis is a central feature of renal IRI. Read More

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http://dx.doi.org/10.1016/j.kint.2019.02.009DOI Listing
March 2019
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Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress.

Redox Biol 2019 Apr 11;24:101195. Epub 2019 Apr 11.

Department of Urology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, PR China. Electronic address:

Ischemia/reperfusion injury (I/R) is one of the leading causes of acute kidney injury (AKI) that typically occurs in renal surgeries. However, renal I/R still currently lacks effective therapeutic targets. In this study, we proved that inhibition of Brd4 with its selective inhibitor, JQ1, could exert a protective role in renal I/R injury in mice. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132317193006
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http://dx.doi.org/10.1016/j.redox.2019.101195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475721PMC
April 2019
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Cirrhosis and the Acute Kidney Injury/Chronic Kidney Disease Continuum: The Path Chosen Matters.

Clin Gastroenterol Hepatol 2019 Apr 17. Epub 2019 Apr 17.

Baylor University Medical Center, Dallas TX.

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193042
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http://dx.doi.org/10.1016/j.cgh.2019.04.030DOI Listing
April 2019
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Development of a novel immunoassay for the simple and fast quantitation of neutrophil gelatinase-associated lipocalin using europium(III) chelate microparticles and magnetic beads.

J Immunol Methods 2019 Apr 17. Epub 2019 Apr 17.

Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, 510515 Guangzhou, China. Electronic address:

Neutrophil gelatinase-associated lipocalin (NGAL) is a promising biomarker for diagnosing acute kidney injury (AKI). Currently, there are few assays for determining NGAL and they are complex, time-consuming or expensive. We aimed to establish an efficient immunoassay to measure NGAL in human urine simply and rapidly. Read More

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http://dx.doi.org/10.1016/j.jim.2019.04.004DOI Listing
April 2019
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Drugs in Development for Acute Kidney Injury.

Drugs 2019 Apr 19. Epub 2019 Apr 19.

Division of Nephrology, Department of Medicine, University of Virginia Health System, 135 Hospital Drive, Suite 1031, Charlottesville, VA, 22908, USA.

The care of patients with acute kidney injury (AKI) has been limited due to the lack of effective therapeutics that can either prevent AKI during high-risk situations or treat AKI once established. A revolution in the scientific understanding of the pathogenesis of AKI has led to the identification of potential therapeutic targets. These targets include pathways involved in inflammation, cellular repair and fibrosis, cellular metabolism and mitochondrial function, oxidative stress, apoptosis, and hemodynamics and oxygen delivery. Read More

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http://dx.doi.org/10.1007/s40265-019-01119-8DOI Listing