85,127 results match your criteria Renal Failure Acute


Acute Kidney Injury Caused by TAFRO Syndrome in a Chinese Patient: Efficacy of Long-Term Corticosteroids Combined with Bortezomib and Cyclophosphamide.

Kidney Blood Press Res 2020 Jun 3:1-7. Epub 2020 Jun 3.

Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China,

Introduction: Thrombocytopenia, ascites, myelofibrosis, renal dysfunction, and organomegaly (TAFRO) syndrome is a newly recognized and rare clinical subtype of Castleman disease. Renal involvement in TAFRO syndrome usually presents with mild proteinuria, microscopic hematuria, and acute renal injury requiring temporary renal replacement. There is no standard therapy available and treatment failures are common, leading to a poor prognosis. Read More

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http://dx.doi.org/10.1159/000505458DOI Listing

miR-195-5p alleviates acute kidney injury through repression of inflammation and oxidative stress by targeting vascular endothelial growth factor A.

Aging (Albany NY) 2020 Jun 3;12. Epub 2020 Jun 3.

Department of Nephrology, Huai'an Second People's Hospital and The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.

Acute kidney injury (AKI) is a common renal dysfunction. Renal ischemia-reperfusion (I/R) injury contributes to AKI progression. The microRNA miR-195-5p can act as a crucial tumor inhibitor in various cancers. Read More

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http://dx.doi.org/10.18632/aging.103160DOI Listing

Cardiovascular Consequences of Acute Kidney Injury.

N Engl J Med 2020 Jun;382(23):2238-2247

From the Department of Anesthesiology and Perioperative Care, University of California, San Francisco, San Francisco (M.L.); and INSERM 942, Lariboisière Hospital, and French Clinical Research Infrastructure Network, Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists (F-CRIN INI-CRCT), Paris (M.L.), and Université de Lorraine, INSERM, Centre d'Investigations Cliniques-Plurithématique 1433, INSERM Unité 1116, Centre Hospitalier Régional Universitaire (CHRU) de Nancy, and F-CRIN INI-CRCT, Nancy (P.R.) - all in France.

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http://dx.doi.org/10.1056/NEJMra1916393DOI Listing

Conservative management of bladder endometriosis with acute renal failure.

Urol Case Rep 2020 Nov 19;33:101263. Epub 2020 May 19.

Department of Urology, Vanderbilt University Medical Center, Nashville, TN, United States.

Endometriosis involving the bladder is rare, but generally has a severe presentation with prominent lower urinary tract symptoms and can progress to renal failure. As endometriosis has a significant effect on quality of life and fertility, treatment plans must be centered on the patient's symptoms, expectations, and priorities. We present a case of a 37-year-old African American female with advanced bladder endometriosis and consequent renal failure, who desired to avoid extensive surgery and maintain her fertility. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260429PMC
November 2020

Page kidney phenomenon in kidney allograft following abdominal trauma.

Urol Case Rep 2020 Sep 23;32:101274. Epub 2020 May 23.

University of Utah School of Medicine, Department of Surgery, Division of Transplantation and Advanced Hepatobiliary Surgery, USA.

The page kidney phenomenon is often associated in patients with abdominal trauma. External compression from a renal hematoma can cause hypertension, and presentation can be delayed following the initial injury. For patients who have a kidney allograft, page kidneys may lead to renal insufficiency and acute renal failure due to the absence of a contralateral kidney to compensate. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260421PMC
September 2020

Granulicatella Causing Infective Endocarditis and Glomerulonephritis.

IDCases 2020 11;21:e00792. Epub 2020 May 11.

Department of Nephrology, UConn Health Center, Farmington, CT, United States.

Granulicatella is a type of nutritionally variant Streptococcus (NVS) that requires special medium for growth. It has shown to cause infective endocarditis which is associated with higher mortality and complications. We present a case of Granulicatella causing endocarditis and glomerulonephritis. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256654PMC

Impact of Diabetes on Complications, Long Term Mortality and Recurrence in 608,890 Hospitalised Patients with Stroke.

Glob Heart 2020 Feb 6;15(1). Epub 2020 Feb 6.

Ageing Clinical and Experimental Research (ACER) Team, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.

Background: Patients with diabetes mellitus (DM) have been found to be at an increased risk of suffering a stroke. However, research on the impact of DM on stroke outcomes is limited.

Objectives: We aimed to examine the influence of DM on outcomes in ischaemic (IS) and haemorrhagic stroke (HS) patients. Read More

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http://dx.doi.org/10.5334/gh.364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218766PMC
February 2020

Acute Fulminant Hepatic Failure and Renal Failure Induced by Oral Amiodarone: A Case Report and Literature Review.

Cureus 2020 May 27;12(5):e8311. Epub 2020 May 27.

Internal Medicine, Jersey Shore University Medical Center, Neptune City, USA.

Amiodarone is a class III antiarrhythmic agent that inhibits adrenergic stimulation by blocking alpha and beta receptors. It prolongs action potential and refractory period in myocardial tissue. Its remarkably long half-life is associated with a myriad of adverse events. Read More

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http://dx.doi.org/10.7759/cureus.8311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255555PMC

Hemorrhagic Cholecystitis in a Patient with Cirrhosis and Rectal Cancer.

Cureus 2020 Apr 29;12(4):e7882. Epub 2020 Apr 29.

Internal Medicine, Citrus Memorial Hospital, Inverness, USA.

Hemorrhagic cholecystitis is a rare presentation of acute calculous cholecystitis which presents with abdominal pain, jaundice, and gastrointestinal bleeding. It is a challenging diagnosis to make because it present similar to other common disorders such as calculous cholecystitis. We present a unique case of hemorrhagic cholecystitis in a patient with cirrhosis and rectal cancer. Read More

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http://dx.doi.org/10.7759/cureus.7882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255552PMC

COVID-19 and Renal Failure: Challenges in the Delivery of Renal Replacement Therapy.

J Clin Med Res 2020 May 8;12(5):276-285. Epub 2020 May 8.

Division of Nephrology, Lynchburg Nephrology Physicians, Lynchburg, VA, USA.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first officially reported in December 2019 in Wuhan City, Hubei province, China, and has since lead to a pandemic. Most cases result in minor symptoms such as cough, fever, sore throat, myalgia, fatigue, nausea, diarrhea, loss of smell, and abdominal pain. As of April 8, 2020, more than 1,485,000 cases of COVID-19 have been reported in more than 200 countries and territories, resulting in over 90,000 deaths. Read More

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http://dx.doi.org/10.14740/jocmr4160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239583PMC

Cisplatin-induced renal toxicity in elderly people.

Ther Adv Med Oncol 2020 18;12:1758835920923430. Epub 2020 May 18.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.

Despite available prevention and treatment measures, such as hydration, diuresis, magnesium supplementation, and amifostine, renal toxicity is still one of the major dose-limiting side effects of cisplatin. The aim of this review is to discuss the issue of cisplatin-induced nephrotoxicity in the elderly. Compared with young patients, the incidences of cisplatin-induced nephrotoxicity and acute kidney injury (AKI) in elderly patients are significantly increased, and survival time may be decreased. Read More

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http://dx.doi.org/10.1177/1758835920923430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238313PMC

Extra-corporeal membrane oxygenation and Eculizumab: Atypical treatments for typical haemolytic uraemic syndrome.

J Intensive Care Soc 2020 May 7;21(2):191-193. Epub 2019 Mar 7.

Haematology Department, University College London Hospital, London, UK.

A 19-year-old female with no medical history presented with bloody diarrhoea. Investigations revealed an acute kidney injury, thrombocytopenia and microangiopathic haemolysis. A diagnosis of haemolytic uraemic syndrome secondary to Shiga toxin-producing 055 was confirmed and supportive therapy commenced in the intensive therapy unit. Read More

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http://dx.doi.org/10.1177/1751143719832184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238477PMC

Use of hemoadsorption in sepsis-associated ECMO-dependent severe ARDS: A case series.

J Intensive Care Soc 2020 May 8;21(2):183-190. Epub 2019 Jan 8.

Department of Intensive Care Medicine, University Hospital Hamburg, Hamburg, Germany.

Introduction: Acute respiratory distress syndrome in the context of severe sepsis and septic shock represents a serious clinical disorder. A recent case series in patients with septic shock and renal failure receiving hemoadsorption treatment showed rapid hemodynamic stabilization and increased survival, particularly in pneumonia patients and in those where therapy was started early. We hypothesized that patients suffering from pneumonia and refractory acute respiratory distress syndrome to the extent that they required extracorporeal membrane oxygenation support could possibly demonstrate the most pronounced benefit from the treatment. Read More

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http://dx.doi.org/10.1177/1751143718818992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238480PMC

Impact of Left Atrial Appendage Exclusion on Short Term Outcomes In Isolated Coronary Artery Bypass Graft Surgery.

Circulation 2020 Jun 3. Epub 2020 Jun 3.

Department of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

The objective of this study was to evaluate the impact of LAA exclusion on short term outcomes in patients with atrial fibrillation undergoing isolated coronary artery bypass graft (CABG) surgery. We queried the 2010-2014 National Readmissions Database (NRD) for patients who underwent coronary artery bypass graft repair with and without left atrial appendage ligation using ICD-9 procedure codes (ICD-9: 36.1xx). Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.044642DOI Listing

Prevalence of acute kidney injury (AKI) in extremely low gestational age neonates (ELGAN).

Pediatr Nephrol 2020 Jun 2. Epub 2020 Jun 2.

Department of Pediatrics, University of Washington/Seattle Children's Hospital, Seattle, WA, USA.

Background: To determine the prevalence and severity of acute kidney injury (AKI) at different time frames in relation to gestational age (GA) and birthweight (BW) in extremely low gestational age neonates (ELGAN). Our hypothesis is that ELGAN with lower GA and lower BW have higher AKI rates.

Methods: A total of 923 ELGAN enrolled in the Preterm Erythropoietin Neuroprotection Trial were evaluated from birth until death or hospital discharge. Read More

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http://dx.doi.org/10.1007/s00467-020-04563-xDOI Listing

Hyperferritinemia and acute kidney injury in pediatric patients receiving allogeneic hematopoietic cell transplantation.

Pediatr Nephrol 2020 Jun 2. Epub 2020 Jun 2.

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: Acute kidney injury (AKI) often occurs in pediatric patients who received allogeneic hematopoietic cell transplantation (HCT). We evaluated the risk and effect of HCT-related AKI in pediatric patients.

Methods: We retrospectively studied the survival and renal outcome of 69 children 100 days and 1-year posttransplant in our institution in 2004-2016. Read More

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http://dx.doi.org/10.1007/s00467-020-04619-yDOI Listing

Metabolic reprogramming associated with progression of renal ischemia reperfusion injury assessed with hyperpolarized [1-C]pyruvate.

Sci Rep 2020 Jun 2;10(1):8915. Epub 2020 Jun 2.

MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Acute kidney injury is a major clinical challenge affecting as many as 1 percent of all hospitalized patients. Currently it is not possible to accurately stratify and predict the outcome of the individual patient. Increasing evidence supports metabolic reprogramming as a potential target for new biomarkers. Read More

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http://dx.doi.org/10.1038/s41598-020-65816-1DOI Listing

Clinical and ultrasound variables for early diagnosis of septic acute kidney injury in bitches with pyometra.

Sci Rep 2020 Jun 2;10(1):8994. Epub 2020 Jun 2.

Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil.

The aetiology of septic acute kidney injury (AKI) is not completely elucidated. Early identification of AKI in septic patients is considered to improve survival rate since it allows rapid treatment onset. We evaluated clinical, haematological, urinary, B-mode, spectral Doppler, and contrast-enhanced ultrasound variables in 20 bitches with pyometra as sepsis models and 12 healthy controls. Read More

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http://dx.doi.org/10.1038/s41598-020-65902-4DOI Listing

Persistent congestion, renal dysfunction and inflammatory cytokines in acute heart failure: a prognosis study.

J Cardiovasc Med (Hagerstown) 2020 Jun 1. Epub 2020 Jun 1.

Cardiac, Thoracic and Vascular Department, University of Pisa, Pisa.

Aims: Chronic kidney dysfunction (CKD) and persistent congestion influence heart failure prognosis, but little is known about the role of inflammation in this association. We assessed the relationship between inflammatory biomarkers, persistent congestion and CKD and their prognostic implications in patients with acute heart failure.

Methods: We enrolled 97 hospitalised patients (mean age: 66 ± 12 years, ejection fraction: 30 ± 8%) with acute heart failure. Read More

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http://dx.doi.org/10.2459/JCM.0000000000000974DOI Listing

Ertapenem-induced encephalopathy.

BMJ Case Rep 2020 Jun 1;13(6). Epub 2020 Jun 1.

Department of Internal Medicine, SCL Health, Denver, Colorado, USA.

Neurotoxicity is an unusual side effect of carbapenems, and it has been reported most commonly presenting as seizures, encephalopathy and hallucinations. Ertapenem neurotoxicity most classically presents as seizures in patients with end-stage renal disease (estimated glomerular filtration rate (eGFR) <30 mL/min/1.73 m). Read More

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http://dx.doi.org/10.1136/bcr-2019-231875DOI Listing

Kidney dysfunction and short term all-cause mortality after transcatheter aortic valve implantation.

Eur J Intern Med 2020 May 30. Epub 2020 May 30.

Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Modena. Electronic address:

Background: Acute kidney injury (AKI) after transcatheter aortic valve implantation (TAVI) has been associated with worse outcomes. However, the impact on outcome of AKI in TAVI-patients is not well established.

Methods: Inoperable patients with severe aortic stenosis (AS) undergoing TAVI in 2010-2018 were enrolled in this study. Read More

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http://dx.doi.org/10.1016/j.ejim.2020.05.027DOI Listing

Urine cell cycle arrest biomarkers distinguish poorly between transient and persistent AKI in early septic shock: a prospective, multicenter study.

Crit Care 2020 Jun 1;24(1):280. Epub 2020 Jun 1.

BoReal Study Group, Medical Intensive Care Unit and EA7517, Amiens University Hospital, F-80054, Amiens, France.

Background: The urine biomarkers tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been validated for predicting and stratifying AKI. In this study, we analyzed the utility of these biomarkers for distinguishing between transient and persistent AKI in the early phase of septic shock.

Methods: We performed a prospective, multicenter study in 11 French ICUs. Read More

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http://dx.doi.org/10.1186/s13054-020-02984-6DOI Listing

Shock wave lithotripsy, for the treatment of kidney stones, results in changes to routine blood tests and novel biomarkers: a prospective clinical pilot-study.

Eur J Med Res 2020 Jun 1;25(1):18. Epub 2020 Jun 1.

North Wales Clinical Research Centre, Betsi Cadwaladr University Health Board (BCUHB) Wrexham Maelor Hospital, Wrexham, Wales, UK.

Background: The number of patients undergoing shock wave lithotripsy (SWL) for kidney stones is increasing annually, and as such the development of post-operative complications, such as haematuria and acute kidney injury (AKI) following SWL, is likely to increase. The aim of the study was to evaluate changes in routine blood and novel biomarkers following SWL, for the treatment of kidney stones.

Methods: Twelve patients undergoing SWL for solitary unilateral kidney stones were recruited. Read More

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http://dx.doi.org/10.1186/s40001-020-00417-2DOI Listing

Fluid removal associates with better outcomes in critically ill patients receiving continuous renal replacement therapy: a cohort study.

Crit Care 2020 Jun 1;24(1):279. Epub 2020 Jun 1.

Department of Critical Care, King's College London, Guy's & St Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, UK.

Background: Fluid overload is associated with morbidity and mortality in patients receiving renal replacement therapy (RRT). We aimed to explore whether fluid overload at initiation of RRT was independently associated with mortality and whether changes in cumulative fluid balance during RRT were associated with outcome.

Methods: We retrospectively analysed the data of patients who were admitted to the multidisciplinary adult intensive care unit (ICU) in a tertiary care centre in the UK between 2012 and 2015 and received continuous RRT (CRRT) for acute kidney injury for at least 24 h. Read More

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http://dx.doi.org/10.1186/s13054-020-02986-4DOI Listing

Acute kidney disease and acute kidney injury biomarkers in coronary care unit patients.

BMC Nephrol 2020 Jun 1;21(1):207. Epub 2020 Jun 1.

Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan.

Background: Acute kidney disease (AKD) describes acute or subacute damage and/or loss of kidney function for a duration of between 7 and 90 days after exposure to an acute kidney injury (AKI) initiating event. This study investigated the predictive ability of AKI biomarkers in predicting AKD in coronary care unit (CCU) patients.

Methods: A total of 269 (mean age: 64 years; 202 (75%) men and 67 (25%) women) patients admitted to the CCU of a tertiary care teaching hospital from November 2009 to September 2014 were enrolled. Read More

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http://dx.doi.org/10.1186/s12882-020-01872-zDOI Listing

[Effects of different crystalloid fluids resuscitation on renal structure and function in sepsis rats].

Zhonghua Nei Ke Za Zhi 2020 Jun;59(6):460-463

Department of Critical Care Medicine, First Hospital of Shanxi Medical University, Taiyuan 030001, China.

To evaluate the effects of resuscitation with normal saline and sodium potassium magnesium calcium and glucose injection on renal structure and function in septic rats. Rat model of sepsis was established by ligation and perforation of cecum. Male SD rats were divided into four groups: sham operation group, sepsis group, saline resuscitation group, sodium potassium magnesium calcium and glucose injection resuscitation group. Read More

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http://dx.doi.org/10.3760/cma.j.cn112138-20191127-00775DOI Listing

Heme-Oxygenase and Kidney Transplantation: A Potential for Target Therapy?

Biomolecules 2020 May 30;10(6). Epub 2020 May 30.

Organ Transplant Unit, University Hospital of Catania, 95123 Catania, Italy.

Kidney transplantation is a well-established therapy for patients with end-stage renal disease. While a significant improvement of short-term results has been achieved in the short-term, similar results were not reported in the long-term. Heme-oxygenase (HO) is the rate-limiting enzyme in heme catabolism, converting heme to iron, carbon monoxide, and biliverdin. Read More

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http://dx.doi.org/10.3390/biom10060840DOI Listing

Risk of incident bleeding after acute kidney injury: A retrospective cohort study.

J Crit Care 2020 May 20;59:23-31. Epub 2020 May 20.

Department of Medicine, Hôpital du Sacré-Coeur de Montréal, 5400 Blvd Gouin West, Université de Montréal, Montreal, Quebec H4J 1C5, Canada; FRCPC, Hôpital du Sacré-Coeur de Montréal, 5400 Gouin Blvd West, Montreal, Quebec H4J 1C5, Canada.. Electronic address:

Purpose: End-stage kidney disease (ESKD) causes bleeding diathesis; however, whether these findings are extrapolable to acute kidney injury (AKI) remains uncertain. We assessed whether AKI is associated with an increased risk of bleeding.

Methods: Single-center retrospective cohort study, excluding readmissions, admissions <24 h, ESKD or kidney transplants. Read More

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http://dx.doi.org/10.1016/j.jcrc.2020.05.003DOI Listing

Improvised Field Expedient Method for Renal Replacement Therapy in a Porcine Model of Acute Kidney Injury.

Disaster Med Public Health Prep 2020 Jun 2:1-9. Epub 2020 Jun 2.

David Grant USAF Medical Center, Travis Air Force Base, CA.

Objective: Dialysis patients may not have access to conventional renal replacement therapy (RRT) following disasters. We hypothesized that improvised renal replacement therapy (ImpRRT) would be comparable to continuous renal replacement therapy (CRRT) in a porcine acute kidney injury model.

Methods: Following bilateral nephrectomies and 2 hours of caudal aortic occlusion, 12 pigs were randomized to 4 hours of ImpRRT or CRRT. Read More

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http://dx.doi.org/10.1017/dmp.2020.107DOI Listing

[Durable Response after Discontinuation Due to Immune-Related Adverse Events in a Patient with Metastatic Clear Cell Renal Cell Carcinoma : A Case Report].

Hinyokika Kiyo 2020 May;66(5):147-151

The Department of Urology, Sapporo Medical University School of Medicine.

A 70-year-old female with metastatic clear cell renal cell carcinoma was treated with nivolumab. After three dosages, she developed interstitial lung disease which required steroid therapy and nivolumab was discontinued. Thereafter, the target lesion continued to shrinkand the best response was partial response 15 weeks after discontinuation of nivolumab, the reduction rate of which eventually reached 49. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_66_5_147DOI Listing

Activation of TFEB-mediated autophagy by trehalose attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury.

Theranostics 2020 27;10(13):5829-5844. Epub 2020 Apr 27.

NHC Key Laboratory of Transplant Engineering and Immunology, Department of Nephrology, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, China.

Cisplatin, an anticancer drug, always leads to nephrotoxicity by causing mitochondrial dysfunction. As a major mechanism for cellular self-degradation, autophagy has been proven to protect against cisplatin-induced acute kidney injury (AKI). Based on the activation of autophagy induced by trehalose, we aimed to investigate the nephroprotective effects of trehalose on cisplatin-induced AKI and its underlying mechanisms. Read More

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http://dx.doi.org/10.7150/thno.44051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255003PMC

SARS-CoV-2 infection and overactivation of Nlrp3 inflammasome as a trigger of cytokine "storm" and risk factor for damage of hematopoietic stem cells.

Leukemia 2020 Jun 1. Epub 2020 Jun 1.

Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Kentucky, USA.

The scientific community faces an unexpected and urgent challenge related to the SARS-CoV-2 pandemic and is investigating the role of receptors involved in entry of this virus into cells as well as pathomechanisms leading to a cytokine "storm," which in many cases ends in severe acute respiratory syndrome, fulminant myocarditis and kidney injury. An important question is if it may also damage hematopoietic stem progenitor cells? Read More

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http://dx.doi.org/10.1038/s41375-020-0887-9DOI Listing

Pediatric Rhabdomyolysis.

Authors:
Heidi S Szugye

Pediatr Rev 2020 Jun;41(6):265-275

Cleveland Clinic Children's, Cleveland Clinic Lerner College of Medicine, Cleveland, OH.

Pediatric rhabdomyolysis is a common diagnosis that pediatricians need to be able to recognize because prompt treatment can prevent potential complications, such as acute kidney injury. The triggers for rhabdomyolysis are extensive, with viruses being the most common cause in pediatric patients. The pathophysiology behind rhabdomyolysis is complex and still being researched, but having a firm understanding of the cascade that results when muscle injury occurs is essential for proper management. Read More

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http://dx.doi.org/10.1542/pir.2018-0300DOI Listing

Liver Transplant Patients with High Levels of Preoperative Serum Ammonia Are at Increased Risk for Postoperative Acute Kidney Injury: A Retrospective Study.

J Clin Med 2020 May 28;9(6). Epub 2020 May 28.

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan 50612, Korea.

Acute kidney injury (AKI) is one of the most frequent postoperative complications after liver transplantation (LT). Increased serum ammonia levels due to the liver disease itself may affect postoperative renal function. This study aimed to compare the incidence of postoperative AKI according to preoperative serum ammonia levels in patients after LT. Read More

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http://dx.doi.org/10.3390/jcm9061629DOI Listing

Post-Ischemic Renal Fibrosis Progression Is Halted by Delayed Contralateral Nephrectomy: The Involvement of Macrophage Activation.

Int J Mol Sci 2020 May 28;21(11). Epub 2020 May 28.

Institute of Translational Medicine, Semmelweis University, 1094 Budapest, Hungary.

(1) Background: Successful treatment of acute kidney injury (AKI)-induced chronic kidney disease (CKD) is unresolved. We aimed to characterize the time-course of changes after contralateral nephrectomy (Nx) in a model of unilateral ischemic AKI-induced CKD with good translational utility. (2) Methods: Severe (30 min) left renal ischemia-reperfusion injury (IRI) or sham operation (S) was performed in male Naval Medical Research Institute (NMRI) mice followed by Nx or S one week later. Read More

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http://dx.doi.org/10.3390/ijms21113825DOI Listing

A case report of recurrent acute pancreatitis associated with life threatening atypical hemolytic uremic syndrome.

Medicine (Baltimore) 2020 May;99(22):e19731

Department of Surgery, University of Florida Health Sciences Center.

Introduction: Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy defined by the sudden onset of hemolytic anemia, thrombocytopenia, and acute kidney injury (AKI). HUS is categorized as either typical, caused by Shiga toxin-producing Escherichia coli infection, or atypical HUS (aHUS), usually complement mediated or secondary to systemic disease. We describe a rare case of aHUS in an adult male patient with recurrent acute pancreatitis. Read More

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http://dx.doi.org/10.1097/MD.0000000000019731DOI Listing

Nivolumab-induced IgA nephropathy in a patient with advanced gastric cancer: A case report.

Medicine (Baltimore) 2020 May;99(21):e20464

Department of Nephrology, Rheumatology, Endocrinology and Metabolism.

Introduction: Immune checkpoint inhibitors including nivolumab, an antibody against programmed death-1, have been increasingly introduced in various cancer treatment regimens, and are reported to be associated with immune-related adverse events. Nivolumab-induced renal injury is generally caused by acute interstitial nephritis and is managed by drug discontinuation and steroid therapy. Although this agent can infrequently induce glomerulonephritis, the pathogenesis and therapeutic strategy remain undetermined. Read More

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http://dx.doi.org/10.1097/MD.0000000000020464DOI Listing

Fenofibrate monotherapy-induced rhabdomyolysis in a patient with post-pancreatitis diabetes mellitus: A rare case report and a review of the literature.

Medicine (Baltimore) 2020 May;99(21):e20390

Department of Hematology of Lu'an People's Hospital, The Lu'an Affiliated Hospital of Anhui Medical University, Lu'an, Anhui, China.

Rationale: Fibrates are widely used to control hypertriglyceridemia and mixed dyslipidemia alone or in combination with statins. These drugs have rare, but severe and potentially vital adverse reactions of rhabdomyolysis and secondary acute renal failure (ARF). The objective of this article is to analyze this adverse effect of fibrates and ensure the safety of drug use. Read More

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http://dx.doi.org/10.1097/MD.0000000000020390DOI Listing

Influence of intraoperative oxygen content on early postoperative graft dysfunction in living donor liver transplantation: A STROBE-compliant retrospective observational study.

Medicine (Baltimore) 2020 May;99(21):e20339

Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital.

The aim of the present study was to investigate the role of intraoperative oxygen content on the development of early allograft dysfunction (EAD) in patients undergoing living donor liver transplantation (LDLT).This retrospective review included 452 adult patients who underwent elective LDLT. Our study population was classified into 2 groups: EAD and non-EAD. Read More

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http://dx.doi.org/10.1097/MD.0000000000020339DOI Listing

Contrast Administration to the Deceased Kidney Donor Has No Impact on Post-Transplant Outcomes.

J Surg Res 2020 May 29;254:261-267. Epub 2020 May 29.

Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.

Background: Contrast-induced acute kidney injury may occur in patients undergoing imaging studies. This study reviews all deceased kidney donors at a single center during a 15-y period to determine if donor contrast exposure results in contrast-induced acute kidney injury in the donor or is associated with worse outcomes in the transplant recipient.

Methods: Donor and recipient renal functions were recorded, including donor serum creatinine and recipient delayed graft function, creatinine clearance at 1 y, and early and late graft survival. Read More

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http://dx.doi.org/10.1016/j.jss.2020.03.061DOI Listing

NSAIDs in CKD: Are They Safe?

Am J Kidney Dis 2020 May 29. Epub 2020 May 29.

Section of Nephrology, Department of Medicine, Yale University School of Medicine, BB114 330 Cedar Street New Haven, CT 06410. Electronic address:

The management of pain in patients with chronic kidney disease (CKD) is challenging for many reasons. These patients have an increased susceptibility to adverse drug effects due to altered drug metabolism and excretion, and there are limited safety data for use in this population despite a high pain burden. Non-steroidal anti-inflammatory drugs (NSAIDs) have long been regarded as dangerous for use in chronic kidney disease patients because of their risk for nephrotoxicity, and thus alternative classes of analgesics, including opioids, have become more commonly used for pain control in this population. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.03.023DOI Listing

Kidney Infarction in Patients With COVID-19.

Am J Kidney Dis 2020 May 29. Epub 2020 May 29.

Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Coronavirus disease 2019 (COVID-19) is a contagious, life-threatening infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Recent findings indicate an increased risk of acute kidney injury during COVID-19. The pathophysiological mechanisms leading to acute kidney injury in COVID-19 are unclear, but may include direct cytopathic effects of the virus on kidney tubular and endothelial cells, indirect damage caused by virus-induced cytokine release, and kidney hypoperfusion due to a restrictive fluid strategy. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258815PMC

Perioperative and Long-Term Results of Female Zenith Fenestrated Aortic Repair.

Ann Vasc Surg 2020 May 29. Epub 2020 May 29.

Indiana University School of Medicine, Department of Surgery, Division of Vascular Surgery, Indianapolis, IN. Electronic address:

Objective: Inferior perioperative outcomes for women receiving major vascular surgery are well-established in the literature in multiple arterial distributions. Therefore, this study was completed to determine the perioperative and durability results associated with females undergoing complex aortic reconstruction using the Zenith Fenestrated platform (ZFEN; Cook Medical, Bloomington, IN).

Methods: A retrospective review of a fenestrated endovascular aortic repair (FEVAR) database capturing all ZFENs performed at our institution between October 2012 and March 2019 was completed. Read More

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http://dx.doi.org/10.1016/j.avsg.2020.05.036DOI Listing

C3d positive donor-specific antibodies have a role in pre-transplant risk stratification of crossmatch positive HLA-incompatible renal transplantation: United Kingdom multicentre study.

Transpl Int 2020 Jun 1. Epub 2020 Jun 1.

Warwick Medical School, University of Warwick, Coventry, United Kingdom.

Background: Anti-HLA antibody characteristics aid to risk-stratify patients and improve long-term renal graft outcomes. Complement activation by donor-specific antibody (DSA) is an important characteristic that may determine renal allograft outcome. There is heterogeneity in graft outcomes within the moderate to high immunological risk cases (crossmatch positive). Read More

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http://dx.doi.org/10.1111/tri.13663DOI Listing