18,170 results match your criteria Renal Disease and Pregnancy


Of Mice and Men: The Effect of Maternal Protein Restriction on Offspring's Kidney Health. Are Studies on Rodents Applicable to Chronic Kidney Disease Patients? A Narrative Review.

Nutrients 2020 May 30;12(6). Epub 2020 May 30.

Nephrology and Dialysis, Centre Hospitalier Le Mans, Avenue Roubillard 194, 72000 Le Mans, France.

In the almost 30 years that have passed since the postulation of the "Developmental Origins of Health and Disease" theory, it has been clearly demonstrated that a mother's dietary habits during pregnancy have potential consequences for her offspring that go far beyond in utero development. Protein malnutrition during pregnancy, for instance, can cause severe alterations ranging from intrauterine growth retardation to organ damage and increased susceptibility to hypertension, diabetes mellitus, cardiovascular diseases and chronic kidney disease (CKD) later in life both in experimental animals and humans. Conversely, a balanced mild protein restriction in patients affected by CKD has been shown to mitigate the biochemical derangements associated with kidney disease and even slow its progression. Read More

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http://dx.doi.org/10.3390/nu12061614DOI Listing

Rapamycin and dexamethasone during pregnancy prevents tuberous sclerosis complex associated cystic kidney disease.

JCI Insight 2020 Jun 2. Epub 2020 Jun 2.

Pediatric Nephrology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel.

Chronic kidney disease is the main cause of mortality in patients with tuberous sclerosis complex disease (TSC). The mechanisms underlying TSC cystic kidney disease remain unclear with no available interventions to prevent cyst formation. Using targeted deletion of TSC1 in nephron progenitor cells, we showed that cysts in TSC1 null embryonic kidneys originate from injured proximal tubular cells with high mTOR complex 1 activity. Read More

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http://dx.doi.org/10.1172/jci.insight.136857DOI Listing

Cardiovascular events following pregnancies complicated by preeclampsia with emphasis on the comparison between early and late onset forms: a systematic review and meta-analysis.

Ultrasound Obstet Gynecol 2020 Jun 2. Epub 2020 Jun 2.

Department of Medicine and Surgery, Unit of Surgical Sciences, Obstetrics and Gynecology, University of Parma, Italy.

Objective: To elucidate whether preeclampsia (PE) and the gestational age at onset of the disease (early-onset vs late-onset PE) has an impact on the risk of long-term cardiovascular complications.

Methods: MedLine and Scopus databases were searched until April 15, 2020 utilizing combinations of the relevant MeSH terms, key words, and word variants for "pre-eclampsia" "cardiovascular disease" and "outcome". Inclusion criteria were: (a) cohort or case-control design; (b) inclusion of women with a diagnosis of pre-eclampsia at the time of the first pregnancy; (c) enough data to compare each outcome in: (I) women with a diagnosis of pre-eclampsia versus women with normal pregnancies and/or (II) women with early-onset pre-eclampsia versus women with late-onset pre-eclampsia. Read More

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http://dx.doi.org/10.1002/uog.22107DOI Listing

imaging of Zika virus reveals dynamics of viral invasion in immune-sheltered tissues and vertical propagation during pregnancy.

Theranostics 2020 16;10(14):6430-6447. Epub 2020 May 16.

CAS Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.

: Zika virus (ZIKV) is a pathogenic virus known to cause a wide range of congenital abnormalities, including microcephaly, Guillain-Barre syndrome, meningoencephalitis, and other neurological complications, in humans. This study investigated the noninvasive detection of ZIKV infection , which is necessary for elucidating the virus's mechanisms of viral replication and pathogenesis, as well as to accelerate the development of anti-ZIKV therapeutic strategies. : In this study, a recombinant ZIKV harbouring Nluc gene (ZIKV-Nluc) was designed, recovered, and purified. Read More

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http://dx.doi.org/10.7150/thno.43177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255039PMC

Plastics derived endocrine-disrupting compounds and their effects on early development.

Birth Defects Res 2020 Jun 1. Epub 2020 Jun 1.

Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.

Despite the fact that the estrogenic effects of bisphenols were first described 80 years ago, recent data about its potential negative impact on birth outcome parameters raises a strong rationale to investigate further. The adverse health effects of plastics recommend to measure the impacts of endocrine-disrupting compounds (EDCs) such as bisphenols (BPA, BPS, BPF), bis(2-ethylhexyl) phthalate, and dibutyl phthalate (DBP) in human health. Exposure to these compounds in utero may program the diseases of the testis, prostate, kidney and abnormalities in the immune system, and cause tumors, uterine hemorrhage during pregnancy and polycystic ovary. Read More

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http://dx.doi.org/10.1002/bdr2.1741DOI Listing

Lower urinary α-Klotho is associated with lower angiotensin-(1-7) and higher blood pressure in young adults born preterm with very low birthweight.

J Clin Hypertens (Greenwich) 2020 May 31. Epub 2020 May 31.

Department of Pediatrics, Wake Forest School of Medicine and Brenner Children's Hospital, Winston Salem, North Carolina, USA.

Early-life factors including preterm birth and VLBW increase the risk of hypertension, but the mechanisms remain poorly understood. Reductions in the anti-aging protein α-klotho are associated with hypertension, possibly due to angiotensin (Ang) II activation, but the mechanisms are incompletely understood and clinical evidence is lacking. The association of α-klotho with the alternative Ang-(1-7) pathway, which counteracts Ang II to lower BP, is undescribed. Read More

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http://dx.doi.org/10.1111/jch.13897DOI Listing

Parenthood and pregnancy in Australians receiving treatment for end-stage kidney disease: protocol of a national study of perinatal and parental outcomes through population record linkage.

BMJ Open 2020 May 25;10(5):e036329. Epub 2020 May 25.

Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia.

Introduction: Achieving parenthood is challenging in individuals receiving renal replacement therapy (RRT; dialysis or kidney transplantation) for end-stage kidney disease. Decision-making regarding parenthood in RRT recipients should be underpinned by robust data, yet there is limited data on parental factors that drive adverse health outcomes. Therefore, we aim to investigate the perinatal risks and outcomes in parents receiving RRT. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-036329DOI Listing

Pregnancy After Kidney Transplantation With Maternal and Pediatric Outcomes: A Single-Center Experience.

Transplant Proc 2020 May 19. Epub 2020 May 19.

Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdańsk, Poland.

Outcomes of pregnancies after kidney transplantation were evaluated. Thirty-one pregnancies in 26 women were noted. The mean maternal age at pregnancy was 31 ± 5 years (range, 23-44 years). Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.01.122DOI Listing

Early-Life Programming and Reprogramming of Adult Kidney Disease and Hypertension: The Interplay between Maternal Nutrition and Oxidative Stress.

Int J Mol Sci 2020 May 18;21(10). Epub 2020 May 18.

Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

Kidney disease and hypertension both have attained the status of a global pandemic. Altered renal programming resulting in kidney disease and hypertension can begin in utero. Maternal suboptimal nutrition and oxidative stress have important implications in renal programming, while specific antioxidant nutrient supplementations may serve as reprogramming strategies to prevent kidney disease and hypertension of developmental origins. Read More

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http://dx.doi.org/10.3390/ijms21103572DOI Listing
May 2020
2.862 Impact Factor

The association between maternal renal function and pregnancy outcomes in type 1 and type 2 diabetes.

Diabetes Res Clin Pract 2020 May 19:108225. Epub 2020 May 19.

Department of Perinatal Medicine, Mercy Health, 163 Studley Road, Heidelberg, VIC, 3084, Australia; Department of Endocrinology and Diabetes, Austin Health, 145 Studley Road, Heidelberg, VIC, 3084, Australia. Electronic address:

Aims: To investigate the prognostic value of estimated glomerular filtration rate (eGFR) and albuminuria in determining pregnancy outcomes in women with type 1 and type 2 diabetes.

Methods: An observational study of pregnant women with type 1 (n = 92) and type 2 diabetes (n = 106) who delivered between 2004 and 2014 at a single tertiary obstetric centre. Clinical and biochemical characteristics were determined and related to major obstetric outcomes: preeclampsia, preterm birth <32 and <37 weeks, and neonatal intensive care admission. Read More

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http://dx.doi.org/10.1016/j.diabres.2020.108225DOI Listing

Clinical course of Coronavirus Disease-2019 (COVID-19) in pregnancy.

Acta Obstet Gynecol Scand 2020 May 22. Epub 2020 May 22.

Department of Obstetrics and Gynecology, University Hospital Puerta de Hierro Majadahonda, Autonoma University of Madrid, Madrid, Spain.

Introduction: The aim of this study is to report our clinical experience in the management of pregnant women infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) during the first thirty days of the Coronavirus disease (COVID-19) pandemic.

Material And Methods: We reviewed clinical data from the first 60 pregnant women with COVID-19 whose care was managed at Puerta de Hierro University Hospital, Madrid, Spain from March 14 to April 14 , 2020. Demographic data, clinical findings, laboratory test results, imaging findings, treatment received, and outcomes were collected. Read More

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http://dx.doi.org/10.1111/aogs.13921DOI Listing

A adenosine receptor antagonists: From caffeine to selective non-xanthines.

Br J Pharmacol 2020 May 18. Epub 2020 May 18.

Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, SE-75124, Uppsala, Sweden.

A long evolution of knowledge of the psychostimulant caffeine, led in the 1960s to another purine natural product, adenosine and its A adenosine receptor (A AR). Adenosine is a short-lived autocrine/paracrine mediator that acts pharmacologically at four ARs in a manner opposite to pan-antagonist caffeine and serves as an endogenous allostatic regulator. Although detrimental in the developing brain, caffeine appears to be cerebroprotective in aging. Read More

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http://dx.doi.org/10.1111/bph.15103DOI Listing
May 2020
4.842 Impact Factor

Evaluating the association between neonatal mortality and maternal high blood pressure, heart disease and gestational diabetes: A case control study.

J Res Med Sci 2020 18;25:23. Epub 2020 Mar 18.

Pediatric Gastroenterology, Hepatology, and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Prevention of noncommunicable diseases (NCDs) during pregnancy is recommended due to severe complications for mothers and infants. Considering that NCDs have a significant impact on infant mortality, this study was conducted to investigate the relationship between mothers' underlying diseases and gestational diabetes and infant mortality in Iran.

Materials And Methods: Mothers who referred to the health centers in nine provinces of Iran were included. Read More

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http://dx.doi.org/10.4103/jrms.JRMS_814_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213007PMC
March 2020
0.608 Impact Factor

International epidemiology databases to evaluate AIDS (IeDEA) in sub-Saharan Africa, 2012-2019.

BMJ Open 2020 May 15;10(5):e035246. Epub 2020 May 15.

Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland

Purpose: The objectives of the International epidemiology databases to evaluate AIDS (IeDEA) are to (i) evaluate the delivery of combination antiretroviral therapy (ART) in children, adolescents and adults in sub-Saharan Africa, (ii) to describe ART regimen effectiveness, durability and tolerability, (iii) to examine HIV-related comorbidities and coinfections and (iv) to examine the pregnancy-related and HIV-related outcomes of women on ART and their infants exposed to HIV or ART in utero or via breast milk.

Participants: IeDEA is organised in four regions (Central, East, Southern and West Africa), with 240 treatment and care sites, six data centres at African, European and US universities, and almost 1.4 million children, adolescents and adult people living with HIV (PLWHIV) enrolled. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-035246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232622PMC

Acute kidney injury in pregnant women following SARS-CoV-2 infection: A case report from Iran.

Respir Med Case Rep 2020 May 13:101090. Epub 2020 May 13.

Tuberculosis and Lung Disease Research Center of Tabriz University of Medical Sciences, Tabriz, Iran.

We reported a 33-year-old female case with novel coronavirus disease 2019 (COVID-19) accompanied by Acute tubular necrosis (ATN). She had a gestational age of 34 weeks. The patient referred to treatment clinic for COVID-19 in Imam Reza hospital of Tabriz (Iran) after having flu-like symptoms. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219375PMC

Assessment of the Etiologies and Outcomes of Antenatal Hydronephrosis in Patients at King Abdulaziz University Hospital.

Cureus 2020 Apr 10;12(4):e7615. Epub 2020 Apr 10.

Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, SAU.

Background Antenatal hydronephrosis (ANH) is the most common congenital abnormality. It is often detected during pregnancy through an antenatal ultrasound (US) examination. This condition is defined as the dilatation of the renal pelvis and/or calyces in neonates. Read More

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http://dx.doi.org/10.7759/cureus.7615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213646PMC

Low birth weight trends: possible impacts on the prevalences of hypertension and chronic kidney disease.

Hypertens Res 2020 May 11. Epub 2020 May 11.

Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.

Worldwide, hypertension and chronic kidney disease (CKD) are highly prevalent disorders and are strong risk factors for cardiovascular disease and end-stage renal disease (ESRD). The developmental origins of health and disease (DOHAD) concept suggests that undesirable perinatal environmental conditions, such as malnutrition, contribute to disease development in adults. Among the known hypertension and CKD risk factors, DOHAD plays a potential role in determining susceptibility to the onset of these diseases in later adulthood. Read More

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http://dx.doi.org/10.1038/s41440-020-0451-zDOI Listing

Pregnancy and non-pregnancy related immune thrombotic thrombocytopenic purpura in women of reproductive age.

J Thromb Thrombolysis 2020 May 9. Epub 2020 May 9.

Hematology Department, Hadassah-Hebrew University Medical Center, POB 12000, Jerusalem, Israel.

Pregnancy is a precipitating factor for immune thrombotic thrombocytopenic purpura (iTTP). We compared the clinical course and outcomes of iTTP in women of reproductive age, between those with pregnancy- and non-pregnancy-related iTTP. A review of all reproductive-aged women diagnosed with iTTP during 2010-2019 in seven university hospitals in Israel. Read More

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http://dx.doi.org/10.1007/s11239-020-02133-4DOI Listing

Fetal and postnatal zinc restriction: sex differences in the renal renin-angiotensin system of newborn and adult Wistar rats.

J Nutr Biochem 2020 Jul 31;81:108385. Epub 2020 Mar 31.

Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Fisiología, Junín 956, Piso 7, CP 1113, Ciudad Autónoma de Buenos Aires, Argentina; CONICET, Universidad de Buenos Aires, Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Junín 956, Piso 2, CP 1113, Ciudad Autónoma de Buenos Aires, Argentina.

This study aimed to evaluate renal morphology and the renal renin-angiotensin system in 6- and 81-day-old male and female offspring exposed to zinc deficiency during fetal life, lactation and/or postnatal growth. Female Wistar rats were fed low- or control zinc diets from pregnancy to offspring weaning. Afterwards, offspring were fed a low- or a control zinc diet until 81 days of life. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2020.108385DOI Listing

Perinatal Outcomes in Fetuses Prenatally Diagnosed with Congenital Diaphragmatic Hernia and Concomitant Lung Lesions: A 10-Year Review.

Fetal Diagn Ther 2020 May 7:1-6. Epub 2020 May 7.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Aim: To describe perinatal outcomes of fetuses with a prenatal diagnosis of a concomitant lung lesion in the setting of congenital diaphragmatic hernia (CDH) and to compare outcomes with an isolated CDH control group without a lung lesion, matched by ultrasound-based prognostic markers including presence of liver herniation and lung measurements.

Material And Methods: This was a retrospective case-control study, wherein all pregnancies diagnosed with CDH and concomitant lung lesions were identified between July 1, 2008, and December 31, 2018. For each case, 2 controls with isolated CDH from the same study period were selected after matching for the presence of liver herniation into the thoracic cavity and ultrasound-based lung measurements either observed over expected lung-to-head ratio (LHR) or absolute LHR with their corresponding gestational age. Read More

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http://dx.doi.org/10.1159/000507481DOI Listing

Paternal deficiency of complement component C1q leads to a preeclampsia-like pregnancy in wild-type female mice and vascular adaptations postpartum.

Am J Physiol Regul Integr Comp Physiol 2020 Jun 6;318(6):R1047-R1057. Epub 2020 May 6.

Magee-Womens Research Institute, Pittsburgh, Pennsylvania.

Preeclampsia is a spontaneously occurring, pregnancy-specific syndrome that is clinically diagnosed by new onset hypertension and proteinuria. Epidemiological evidence describes an association between a history of preeclampsia and increased risk for cardiovascular disease in later life; however, the mechanism(s) driving this relationship are unclear. Our study aims to leverage a novel preeclampsia-like mouse model, the C1q model, to help elucidate the acute and persistent vascular changes during and following a preeclampsia-like pregnancy. Read More

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http://dx.doi.org/10.1152/ajpregu.00353.2019DOI Listing

[Acute fatty liver of pregnancy in a Peruvian pregnant woman: a case report].

Rev Gastroenterol Peru 2020 Jan-Mar;40(1):80-84

Hospital "Víctor Lazarte Echegaray", EsSalud. Trujillo, Perú.

Acute fatty liver of pregnancy is a rare disease of pregnancy that occurs with greater preponderance during the third trimester. Its etiology is unknown, but there is evidence of a micro vesicular fat deposit in the hepatocyte. It has a maternal-fetal mortality up to 20% because the only treatment is to end gestation. Read More

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Pregnant woman with primary membranous nephropathy - case report.

Pol Merkur Lekarski 2020 Apr;48(284):105-107

Department of Transplantation Medicine, Nephrology and Internal Medicine, Medical University of Warsaw.

Membranous nephropathy is a common form of glomerulonephritis typically presenting between 30 to 50 years of age with nephrotic range proteinuria, with one third of patients undergoing spontaneous remission, one third experiencing non-progressive CKD (Chronic Kidney Disease) while the remaining third progressing to ESRD (end stage renal disease).

Case Report: A 21-year old pregnant female developed massive proteinuria and hypoalbuminemia during first weeks of pregnancy and required intensive nephrological evaluation and treatment. Renal biopsy was performed, microscopic examination was consistent with Membranous Nephropathy and as anti-PLA2R antibodies tested positive, active disease was confirmed. Read More

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Hypertensive Disorders of Pregnancy and Future Cardiovascular Health.

Front Cardiovasc Med 2020 15;7:59. Epub 2020 Apr 15.

Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, University of London, London, United Kingdom.

Hypertensive disorders of pregnancy (HDP) occur in almost 10% of gestations. These women are known to have higher cardiovascular morbidity and mortality later in life in comparison with parous controls who had normotensive pregnancies. Several studies have demonstrated that women with preeclampsia present in a state of segmental impaired myocardial function, biventricular chamber dysfunction, adverse biventricular remodeling, and hypertrophy, a compromised hemodynamic state and indirect echocardiographic signs of localized myocardial ischemia and fibrosis. Read More

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http://dx.doi.org/10.3389/fcvm.2020.00059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174679PMC

Urinary strips for protein assays: easy to do but difficult to interpret!

J Nephrol 2020 Apr 23. Epub 2020 Apr 23.

Service de Néphrologie-Dialyse-Transplantation, University of Liège, CHU Sart Tilman (CHU ULg), 4000, Liège, Belgium.

Urine samples can be readily obtained from patients in everyday clinical practice. Therefore, the availability of urine allows physicians to obtain relevant clinical information in a timely manner. Since the measurement of urinary protein levels is essential in diagnosing and treating a host of diseases, the potential detection of urinary proteins by urinary strips in an easy, quick, and cheap way is very attractive. Read More

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http://dx.doi.org/10.1007/s40620-020-00735-yDOI Listing

Guidelines of the Italian Society of Videosurgery in Infancy for the minimally invasive treatment of the ureteropelvic-junction obstruction.

Pediatr Med Chir 2019 Dec 19;41(2). Epub 2019 Dec 19.

Pediatric Surgery and Urologic Unit, Local Health Unit 8, S. Bortolo Hospital, Vicenza.

The hydronephrosis, characterized by the dilation of the renal pelvicalyceal system with possible functional damage to the renal parenchyma, is the most common congenital abnormality of the urinary system detected in utero through the prenatal ultrasound screening. (.. Read More

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http://dx.doi.org/10.4081/pmc.2019.232DOI Listing
December 2019

Datasets describing the introduction of the high-sensitive troponin in the emergency department.

Data Brief 2020 Jun 8;30:105481. Epub 2020 Apr 8.

Horten Centre for Patient Oriented Research and Knowledge Transfer, University of Zurich, Pestalozzistrasse 24, Zurich CH-8032, Switzerland.

Chest pain is a common clinical condition in the emergency department. A high sensitive (hs) troponin test assay may help to identify patients with acute coronary syndrome earlier compared to conventional tests but also entails the risk of a high proportion of positive test results in patients without cardiac disease. We assessed the impact of the introduction of the hs-troponin test in clinical practice in an emergency department. Read More

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http://dx.doi.org/10.1016/j.dib.2020.105481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160515PMC

The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy.

Exp Mol Med 2020 Apr 22;52(4):682-690. Epub 2020 Apr 22.

Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.

Lineage-specific genetic programs rely on cell-restricted super-enhancers, which are platforms for high-density transcription factor occupation. It is not known whether super-enhancers synergize specifically with their native promoters or provide autonomous and independent regulatory platforms. Here, we investigated the ability of the mammary Wap super-enhancer to activate the promoter of the juxtaposed and ubiquitously expressed Tbrg4 gene in the mouse mammary gland. Read More

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http://dx.doi.org/10.1038/s12276-020-0425-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210877PMC

Interleukin-17 signaling mediates cytolytic natural killer cell activation in response to placental ischemia.

Am J Physiol Regul Integr Comp Physiol 2020 Jun 22;318(6):R1036-R1046. Epub 2020 Apr 22.

Department of Pharmacology, University of Mississippi Medical Center, Jackson, Mississippi.

T-helper (T)17s, IL-17, and cytolytic natural killer cells (cNKs) are increased in preeclampsia and contribute to the hypertension, inflammation, and fetal growth restriction that occurs in response to placental ischemia in the reduced uterine perfusion pressure (RUPP) rat model of preeclampsia. As IL-17 stimulates NK cytotoxicity in vitro, we tested the hypothesis that IL-17 inhibition in RUPP rats would decrease cNK activation as a mechanism to improve maternal and fetal outcomes. On gestation (GD) , rats undergoing RUPP received a miniosmotic pump infusing IL-17RC (100 pg/day), a soluble IL-17 receptor (RUPP + IL-17RC). Read More

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http://dx.doi.org/10.1152/ajpregu.00285.2019DOI Listing

Maternal risk factors for the VACTERL association: A EUROCAT case-control study.

Birth Defects Res 2020 May 22;112(9):688-698. Epub 2020 Apr 22.

Department for Health Evidence, Radboud Institute for Health Sciences, Radboud university medical center (Radboudumc), Nijmegen, The Netherlands.

Background: The VACTERL association (VACTERL) is the nonrandom occurrence of at least three of these congenital anomalies: vertebral, anal, cardiac, tracheoesophageal, renal, and limb anomalies. Despite suggestions for involvement of several genes and nongenetic risk factors from small studies, the etiology of VACTERL remains largely unknown.

Objective: To identify maternal risk factors for VACTERL in offspring in a large European study. Read More

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http://dx.doi.org/10.1002/bdr2.1686DOI Listing

Comparing acute fatty liver of pregnancy from hemolysis, elevated liver enzymes, and low platelets syndrome.

J Matern Fetal Neonatal Med 2020 Apr 19:1-11. Epub 2020 Apr 19.

Department of Obstetrics and Gynecology, University of Texas, Southwestern Medical Center, Parkland Health and Hospital Systems, Dallas, TX, USA.

Acute fatty liver of pregnancy (AFLP) and hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome are both associated with significant maternal and perinatal morbidity and mortality. Because of the overlap of several clinical and laboratory findings differentiation can sometimes be difficult. Both disorders have been of interest for more than 100 years, however they were not completely characterized until the early 1980s. Read More

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http://dx.doi.org/10.1080/14767058.2020.1754790DOI Listing

Dysregulation of complement system during pregnancy in patients with preeclampsia: A prospective study.

Mol Immunol 2020 Apr 16;122:69-79. Epub 2020 Apr 16.

Key Laboratory of Renal Disease, Ministry of Health of China, Renal Division, Department of Medicine, Peking University First Hospital, PR China; Peking-Tsinghua Center for Life Sciences, Beijing, PR China.

Recent studies have shown that aberrant activation of the complement system plays an important role in the pathogenesis of preeclampsia. There is evidence to suggest that aberrant activation of the complement system may already be present during the first trimester. Here, we performed a prospective study in which peripheral blood samples were collected from 500 women during pregnancy. Read More

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http://dx.doi.org/10.1016/j.molimm.2020.03.021DOI Listing

Preeclampsia and the Ten-Year Risk of Incident Chronic Kidney Disease.

Cardiorenal Med 2020 16;10(3):188-197. Epub 2020 Apr 16.

Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran,

Background: Although preeclampsia (PE), as an endothelial disorder can lead to renal dysfunction during pregnancy, results of studies focusing on the potential long-term potential effects of PE on renal function are insufficient and those available are controversial. This study investigated the incidence rate and risk of chronic kidney disease (CKD) among women with prior history of PE compared with healthy controls in a long-term population-based study.

Methods: This was a prospective population-based cohort study. Read More

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http://dx.doi.org/10.1159/000506469DOI Listing

Periodontal disease and its impact on general health in Latin America. Section V: Treatment of periodontitis.

Braz Oral Res 2020 9;34(supp1 1):e026. Epub 2020 Apr 9.

Universidade de Guarulhos - UnG, Dental Research Division, Department of Periodontology, Guarulhos, SP, Brazil.

Gingivitis and periodontitis are associated with a negative impact on Oral Health Related Quality of Life (OHRQoL), exerting a significant influence on aspects related to the patients' function and esthetics. Periodontitis has been associated with several systemic conditions, including adverse pregnancy outcomes, cardiovascular diseases, type 2 diabetes mellitus (DM), respiratory disorders, fatal pneumonia in hemodialysis patients, chronic renal disease and metabolic syndrome. The aim of this paper was to review the results of different periodontal treatments and their impacts on patients' OHRQoL and systemic health. Read More

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http://dx.doi.org/10.1590/1807-3107bor-2020.vol34.0026DOI Listing

Spontaneous preterm birth and cervical length in a pregnant Asian population.

PLoS One 2020 13;15(4):e0230125. Epub 2020 Apr 13.

Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore, Singapore.

Objective: Preterm birth (birth before 37 weeks of completed gestation) is the leading cause of neonatal death, and has an incidence of 5-13% which is believed to be on the rise. The objective of this study was to determine the rate of spontaneous preterm birth and investigate the relationship between preterm birth and cervical length in a pregnant Asian population.

Materials And Methods: A prospective observational study between September 2010 and November 2013 was performed at KK Women's and Children's Hospital, Singapore. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230125PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153874PMC

Consumption of non-nutritive sweeteners during pregnancy.

Am J Obstet Gynecol 2020 Apr 8. Epub 2020 Apr 8.

Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI. Electronic address:

In an effort to reduce sugar consumption to prevent diabetes mellitus and cardiovascular diseases, "sugar-free" or "no added sugar" products that substitute sugar with non-nutritive sweeteners (NNSs) (eg, Splenda, Sweet'N Low, and Stevia) have become increasingly popular. The use of these products during pregnancy has also increased, with approximately 30% of pregnant women reporting intentional NNS consumption. In clinical studies with nonpregnant participants and animal models, NNSs were shown to alter gut hormonal secretion, glucose absorption, appetite, kidney function, in vitro insulin secretion, adipogenesis, and microbiome dysbiosis of gut bacteria. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.03.034DOI Listing

Association between basal proteinuria levels and pregnancy outcomes in familial Mediterranean fever.

J Obstet Gynaecol 2020 Apr 9:1-4. Epub 2020 Apr 9.

Department of Maternal-Fetal Medicine Unit, University of Health Sciences, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.

We aimed to investigate whether proteinuria in the first trimester of pregnancy in Familial Mediterranean fever (FMF) patients has an impact on pregnancy outcome and perinatal and neonatal outcome of pregnancies. A total of 66 pregnant with FMF were compared with healthy controls at the same gestational weeks. Patients with FMF had a higher antenatal hospitalisation rate (34. Read More

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http://dx.doi.org/10.1080/01443615.2019.1700944DOI Listing

[Construction and validation of pregnancy risk prediction model for pregnant women with chronic kidney disease].

Zhonghua Fu Chan Ke Za Zhi 2020 Mar;55(3):172-176

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Meuitus, Beijing 100034, China.

To construct the pregnancy risk prediction model of chronic kidney disease (CKD) pregnant women by analyzing their renal function and pregnancy outcome in the first trimester. Totally 313 CKD women with 322 pregnancies who had deliveries in Peking University First Hospital from March 2009 to December 2018 were retrospectively analyzed. The history of kidney disease and renal function in the first trimester were collected, and the relationship between CKD and premature delivery, low birth weight infants, severe preeclampsia and fetal loss were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112141-20190911-00482DOI Listing

Hemodynamic changes after spinal anesthesia in preeclamptic patients undergoing cesarean section at a tertiary referral center in Ethiopia: a prospective cohort study.

Patient Saf Surg 2020 31;14. Epub 2020 Mar 31.

2Department of anesthesia, Univesity of Gondar, Gondar, Ethiopia.

Background: Spinal anesthesia-induced maternal hypotension is the most frequent complication associated with maternal morbidity and mortality during Cesarean section. The aim of this study was to compare the incidence and magnitude of hemodynamic changes in preeclamptic and non-preeclamptic parturients undergone Cesarean section under spinal anesthesia.

Method: A prospective cohort study was conducted from 01 February to 28 May 2019 in preeclamptic and non-preeclamptic parturients. Read More

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http://dx.doi.org/10.1186/s13037-020-00234-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110765PMC

Preeclampsia beyond pregnancy: long-term consequences for mother and child.

Am J Physiol Renal Physiol 2020 Jun 6;318(6):F1315-F1326. Epub 2020 Apr 6.

Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.

Preeclampsia is defined as new-onset hypertension after the 20th wk of gestation along with evidence of maternal organ failure. Rates of preeclampsia have steadily increased over the past 30 yr, affecting ∼4% of pregnancies in the United States and causing a high economic burden (22, 69). The pathogenesis is multifactorial, with acknowledged contributions by placental, vascular, renal, and immunological dysfunction. Read More

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http://dx.doi.org/10.1152/ajprenal.00071.2020DOI Listing

Micronuclei and disease - Report of HUMN project workshop at Rennes 2019 EEMGS conference.

Mutat Res 2020 Feb - Mar;850-851:503133. Epub 2020 Jan 10.

Department of Human Sciences and Quality of Life Promotion, San Raffaele University, Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele Pisana, Rome, Italy.

The "Micronuclei and Disease" workshop was organized by the HUMN Project consortium and hosted by the European Environmental Mutagen and Genomics Society at their annual meeting in Rennes, France, on 23 May 2019. The program of the workshop focused on addressing the emerging evidence linking micronucleus (MN) frequency to human disease. The first objective was to review what has been published and evaluate the level and quality of evidence for the connection between MN frequency and various diseases through all life stages. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2020.503133DOI Listing

Updates in Diagnosis and Management of Preeclampsia in Women with CKD.

Clin J Am Soc Nephrol 2020 Apr 2. Epub 2020 Apr 2.

Division of Women and Children's Health, King's College London, London, United Kingdom;

It is estimated that women with CKD are ten times more likely to develop preeclampsia than women without CKD, with preeclampsia affecting up to 40% of pregnancies in women with CKD. However, the shared phenotype of hypertension, proteinuria, and impaired excretory kidney function complicates the diagnosis of superimposed preeclampsia in women with CKD who have hypertension and/or proteinuria that predates pregnancy. This article outlines the diagnoses of preeclampsia and superimposed preeclampsia. Read More

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http://dx.doi.org/10.2215/CJN.15121219DOI Listing

A homozygote frameshift mutation in OCLN gene result in Pseudo-TORCH syndrome type I: A case report extending the phenotype with central diabetes insipidus and renal dysfunction.

Eur J Med Genet 2020 Jun 30;63(6):103923. Epub 2020 Mar 30.

Department of Medical Genetics, Cukurova University Faculty of Medicine, Adana, Turkey. Electronic address:

Intrauterine infections with the pathogens, including toxoplasmosis, other (syphilis, varicella, mumps, parvovirus, and HIV), rubella, cytomegalovirus, and herpes simplex (TORCH) in susceptible individuals during pregnancy, result in microcephaly, white matter disease, cerebral atrophy, and calcifications in the fetus. Pseudo-TORCH syndrome is an umbrella term, consisting of several syndromes, resultant from different genetic alterations and pathogenetic mechanisms. Band-like calcification with simplified gyration and polymicrogyria (BLC-PMG) is one of these conditions, resultant from biallelic mutations in the OCLN gene, located in the chromosome 5q13. Read More

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http://dx.doi.org/10.1016/j.ejmg.2020.103923DOI Listing

Risk of long-term renal disease in women with a history of preterm delivery: a population-based cohort study.

BMC Med 2020 Apr 1;18(1):66. Epub 2020 Apr 1.

School of Public Health, Western Gateway Building, University College Cork, Cork, Ireland.

Background: Preterm delivery is an independent risk factor for maternal cardiovascular disease. Little is known about the association between preterm delivery and maternal renal function. This study aimed to examine whether women who experience preterm delivery are at increased risk of subsequent chronic kidney disease (CKD) and end-stage kidney disease (ESKD). Read More

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http://dx.doi.org/10.1186/s12916-020-01534-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110747PMC

The study of factors associated with pregnancy outcomes in patients with systemic lupus erythematosus.

BMC Res Notes 2020 Mar 30;13(1):185. Epub 2020 Mar 30.

Department of Biostatistics and Public Health, Faculty of Health, Kashan University of Medical Sciences, Pezeshk Blvd, 5th of Qotb-e Ravandi Blvd, P.O.Box: 8715973449, Kashan, Iran.

Objectives: Systemic lupus erythematosus (SLE) is an autoimmune disease that can lead to unfavorable pregnancy complications in women. This study aimed to evaluate the factors associated with pregnancy outcomes in patients with SLE.

Results: Fifty-nine pregnant women with SLE (121 pregnancies) participated in this retrospective cohort study. Read More

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http://dx.doi.org/10.1186/s13104-020-05039-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108499PMC

Current understanding and unknown aspects of the treatment of granulomatosis with polyangiitis (Wegener's granulomatosis): Opportunities for future studies.

Curr Rheumatol Rev 2020 Mar 31. Epub 2020 Mar 31.

Amir-A'lam Hospital, Tehran University of Medical Sciences, Tehran. Iran.

Granulomatosis with polyangiitis (GPA) is a rare and systemic autoimmune disease, causing necrotizing vasculitis of small arteries and veins. The majority of diagnosed patients with GPA have circulating antineutrophil cytoplasmic antibodies (ANCA) directed against proteinase 3 (PR3). Here, we have reviewed the last findings and uncertainties regarding treatments of GPA. Read More

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http://dx.doi.org/10.2174/1573397116666200331130919DOI Listing

The Potent Antioxidant MitoQ Protects Against Preeclampsia During Late Gestation but Increases the Risk of Preeclampsia When Administered in Early Pregnancy.

Antioxid Redox Signal 2020 May 6. Epub 2020 May 6.

Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Although preeclampsia (PE) has been attributed to excessive oxidative stress (OS) in the placenta, mild antioxidants failed to prevent PE in clinical trials. As mitochondria are a major source of OS, this study assessed the potential of a potent mitochondria-targeting antioxidant MitoQ in the prevention of PE. Placentas from women with PE and from reduced uterine perfusion pressure (RUPP) mice demonstrated significantly higher OS, along with increased mitochondrial damage and compromised glutathione peroxidase (GPx) activities. Read More

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http://dx.doi.org/10.1089/ars.2019.7891DOI Listing
May 2020
7.407 Impact Factor

Serelaxin alleviates cardiac fibrosis through inhibiting endothelial-to-mesenchymal transition via RXFP1.

Theranostics 2020 4;10(9):3905-3924. Epub 2020 Mar 4.

Department of Cardiology and Pneumology, University Medical Center of Göttingen, Georg-August University, Göttingen, Germany.

: Cardiac fibrosis is an integral constituent of every form of chronic heart disease, and persistence of fibrosis reduces tissue compliance and accelerates the progression to heart failure. Relaxin-2 is a human hormone, which has various physiological functions such as mediating renal vasodilation in pregnancy. Its recombinant form Serelaxin has recently been tested in clinical trials as a therapy for acute heart failure but did not meet its primary endpoints. Read More

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http://dx.doi.org/10.7150/thno.38640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086357PMC
March 2020
7.827 Impact Factor

Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia.

J Med Virol 2020 Mar 28. Epub 2020 Mar 28.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

The aim is to evaluate pregnant women infected with coronavirus disease 2019 (COVID-19) and provide help for clinical prevention and treatment. All five cases of pregnant women confirmed COVID-19 were collected among patients who admitted to the Maternal and Child Hospital of Hubei Province between January 20 and February 10, 2020. All patients, aging from 25 to 31 years old, had the gestational week from 38th weeks to 41st weeks. Read More

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http://dx.doi.org/10.1002/jmv.25789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228212PMC