17,458 results match your criteria Renal Disease and Pregnancy


Successful Pregnancy Outcome in a Recipient With Simultaneous Kidney and Pancreas Transplant Who Underwent Posttransplant Metabolic Surgery.

Exp Clin Transplant 2019 Jan;17(Suppl 1):220-222

From the Nephrology Department, Hamed Al-Essa Organ Transplant Center, Ibn Sina Hospital, Sabah Area, Kuwait.

Although chronic kidney disease decreases fertility, kidney transplantation provides restoration of fertility in women, enabling them to get pregnant. Data available from registries have shown that pregnancy is feasible in solid-organ transplant recipients without significant impact on long-term graft function. Despite these reassuring data, some studies have reported that one-third of female transplant recipients are still actively being counseled against pregnancy. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P75DOI Listing
January 2019

Thymoglobulin-Resistant T-Cell-Mediated Acute Rejection in a Pregnant Renal Transplant Recipient: Case Report and Review of the Literature.

Exp Clin Transplant 2019 Jan;17(Suppl 1):159-163

From the Hamed Al-Essa Organ Transplant Center, Kuwait.

To avoid graft rejection during pregnancy, frequent monitoring of serum drug levels is recommended. Pregnancy induces hyperfiltration in transplanted kidneys, as in native kidneys; therefore, detection of rejection can be difficult when monitoring by serum creatinine. If rejection is suspected, ultrasonographguided graft biopsy can be done; once proven, it can be treated with pulse steroids, but data are scarce regarding other agents. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P38DOI Listing
January 2019

Living-Donor Kidney Transplant With Preformed Donor-Specific Antibodies.

Exp Clin Transplant 2019 Jan;17(Suppl 1):43-49

From the Department of Nephrology, Toho University, Faculty of Medicine, Tokyo, Japan.

Objectives: We investigated outcomes in living-donor kidney transplant recipients with preformed donor-specific antibodies (detected with flow cytometry and specified with the LABScreen single antigen test) under desensitization pretransplant and immunosuppression posttransplant.

Materials And Methods: Of 15 recipients included, 8 had ABO-incompatible kidney transplant. Six patients had sensitization caused by pregnancy, 8 by blood transfusion, 5 by previous transplants, and 1 by unknown cause. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.L42DOI Listing
January 2019

The impact of different classes of lupus nephritis on maternal and fetal outcomes: a cohort study of 147 pregnancies.

Lupus 2019 Feb 18:961203319829825. Epub 2019 Feb 18.

2 Department of Rheumatology, State University of Rio de Janeiro, Brazil.

Objective: To analyze the impact of different classes of lupus nephritis as risk variables for maternal and fetal adverse outcomes in a cohort of pregnant lupus patients.

Methods: This is a cohort study with retrospective and prospective data collection, conducted at the University Hospital of State University of Rio de Janeiro, Brazil, from 2011 to 2016. A total of 147 pregnancies of 137 systemic lupus erythematosus patients of whom 66 had lupus nephritis were included. Read More

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http://dx.doi.org/10.1177/0961203319829825DOI Listing
February 2019

Plasticity of the Maternal Vasculature During Pregnancy.

Annu Rev Physiol 2019 Feb;81:89-111

Department of Biology, Ecology and Earth Science, University of Calabria, 87036 Arcavacata di Rende (CS), Italy.

Maternal cardiovascular changes during pregnancy include an expansion of plasma volume, increased cardiac output, decreased peripheral resistance, and increased uteroplacental blood flow. These adaptations facilitate the progressive increase in uteroplacental perfusion that is required for normal fetal growth and development, prevent the development of hypertension, and provide a reserve of blood in anticipation of the significant blood loss associated with parturition. Each woman's genotype and phenotype determine her ability to adapt in response to molecular signals that emanate from the fetoplacental unit. Read More

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http://dx.doi.org/10.1146/annurev-physiol-020518-114435DOI Listing
February 2019
2 Reads

Simultaneous targeting of linked loci in mouse embryos using base editing.

Sci Rep 2019 Feb 7;9(1):1662. Epub 2019 Feb 7.

Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland, 20892, USA.

A particular challenge in genome engineering has been the simultaneous introduction of mutations into linked (located on the same chromosome) loci. Although CRISPR/Cas9 has been widely used to mutate individual sites, its application in simultaneously targeting of linked loci is limited as multiple nearby double-stranded DNA breaks created by Cas9 routinely result in the deletion of sequences between the cleavage sites. Base editing is a newer form of genome editing that directly converts C∙G-to-T∙A, or A∙T-to-G∙C, base pairs without introducing double-stranded breaks, thus opening the possibility to generate linked mutations without disrupting the entire locus. Read More

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http://www.nature.com/articles/s41598-018-33533-5
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http://dx.doi.org/10.1038/s41598-018-33533-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367434PMC
February 2019
4 Reads
5.078 Impact Factor

The relationship between mercury exposure and epigenetic alterations regarding human health, risk assessment and diagnostic strategies.

J Trace Elem Med Biol 2019 Mar 14;52:37-47. Epub 2018 Nov 14.

Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences (TUMS), Tehran, Iran; Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Exposure to the environmental toxicants poses a serious threat to human health. The extent of exposure and the development of diseases are interrelated with each other. Chronic exposure to mercury (Hg) increases the risk of developing serious human disorders from embryo to adulthood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0946672X183046
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http://dx.doi.org/10.1016/j.jtemb.2018.11.006DOI Listing
March 2019
3 Reads
2.491 Impact Factor

The Safety, Tolerability, and Effects on the Systemic Inflammatory Response and Renal Function of the Human Chorionic Gonadotropin Hormone-Derivative EA-230 Following On-Pump Cardiac Surgery (The EASI Study): Protocol for a Randomized, Double-Blind, Placebo-Controlled Phase 2 Study.

JMIR Res Protoc 2019 Feb 6;8(2):e11441. Epub 2019 Feb 6.

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, Netherlands.

Background: The cardiac surgery-induced systemic inflammatory response may induce postoperative hemodynamic instability and impairment of renal function. EA-230, a linear tetrapeptide (A-Q-G-V), is derived from the beta chain of the human chorionic gonadotropin pregnancy hormone. It has shown immunomodulatory and renoprotective effects in several animal models of systemic inflammation. Read More

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http://dx.doi.org/10.2196/11441DOI Listing
February 2019
2 Reads

Effect of antenatal and infant micronutrient supplementation on middle childhood and early adolescent development outcomes in Tanzania.

Eur J Clin Nutr 2019 Feb 4. Epub 2019 Feb 4.

Department of Global Health and Population, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Background: There is growing evidence that nutritional interventions in the first 1000 days of life may influence long-term health and development outcomes. Few studies have examined the effect of maternal and infant micronutrient supplementation on development outcomes in sub-Saharan Africa.

Methods: We conducted a follow-up study of two randomized trials of antenatal and infant micronutrient supplementation conducted in Dar es Salaam, Tanzania. Read More

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http://dx.doi.org/10.1038/s41430-019-0403-3DOI Listing
February 2019
3 Reads

Postpartum diabetes screening among low income women with gestational diabetes in Missouri 2010-2015.

BMC Public Health 2019 Feb 4;19(1):148. Epub 2019 Feb 4.

Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, 660 S. Euclid Ave, Campus Box 8100, St. Louis, MO, 63110, USA.

Background: Gestational diabetes increases risk for type 2 diabetes seven-fold, creating a large public health burden in a young population. In the US, there are no large registries for tracking postpartum diabetes screening among women in under-resourced communities who face challenges with access to care after pregnancy. Existing data from Medicaid claims is limited as women often lose this coverage within months of delivery. Read More

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http://dx.doi.org/10.1186/s12889-019-6475-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360751PMC
February 2019
1 Read

Confidence in Women's Health: A Cross Border Survey of Adult Nephrologists.

J Clin Med 2019 Feb 3;8(2). Epub 2019 Feb 3.

Division of Nephrology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada.

A range of women's health issues are intimately related to chronic kidney disease, yet nephrologists' confidence in counseling or managing these issues has not been evaluated. The women's health working group of Cure Glomerulonephropathy (CureGN), an international prospective cohort study of glomerular disease, sought to assess adult nephrologists' training in, exposure to, and confidence in managing women's health. A 25-item electronic questionnaire was disseminated in the United States (US) and Canada via CureGN and Canadian Society of Nephrology email networks and the American Society of Nephrology Kidney News. Read More

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http://dx.doi.org/10.3390/jcm8020176DOI Listing
February 2019
1 Read

Perinatal iron deficiency and a high salt diet cause long-term kidney mitochondrial dysfunction and oxidative stress.

Cardiovasc Res 2019 Jan 31. Epub 2019 Jan 31.

Department of Pharmacology, University of Alberta.

Aims: Perinatal iron deficiency alters developmental trajectories of offspring, predisposing them to cardiovascular dysfunction in later life. The mechanisms underlying this long-term programming of renal function have not been defined. We hypothesized perinatal iron deficiency causes hypertension and alters kidney metabolic function and morphology in a sex-dependent manner in adult offspring. Read More

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http://dx.doi.org/10.1093/cvr/cvz029DOI Listing
January 2019
1 Read

Increased Risk of Incident Chronic Medical Conditions in Infertile Women: Analysis of Us Claims Data.

Am J Obstet Gynecol 2019 Jan 30. Epub 2019 Jan 30.

Department of Urology, Stanford University School of Medicine, Stanford, California.

Background: The risk of common chronic medical conditions among infertile women is not known.

Objective: To study the association between female infertility and risk of incident chronic disease.

Study Design: Retrospective cohort analysis using the Optum® de-identified Clinformatics© Datamart from 2003-2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029378193024
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http://dx.doi.org/10.1016/j.ajog.2019.01.214DOI Listing
January 2019
4 Reads

THE RESTLESS LEGS SYNDROME (REVIEW).

Georgian Med News 2018 Dec(285):74-81

Institute of Neurology and Neuropsychology, Tbilisi; Caucasus International University, Tbilisi; Ilia State University, Tbilisi, Georgia; Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.

The restless legs syndrome (RLS), also known as Willis-Ekbom disease, is a common sleep related neurological disorder with prevalence between 1 and 10%, increasing with age. Women are more frequently affected than men. RLS is characterized by an urge to move the legs accompanied by uncomfortable and unpleasant sensations in the legs, worsening of complaints during periods of rest, improvement by movement and an increase of symptoms in the evening or at night. Read More

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December 2018
3 Reads

What we do and do not know about women and kidney diseases; Questions unanswered and answers unquestioned: Reflection on World Kidney Day and International Woman's Day.

Ter Arkh 2018 Jun;90(6):4-14

Department of Medicine, Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada.

Chronic kidney disease affects approximately 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women's health and specifically their kidney health, on the community, and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly. Girls and women, who make up approximately 50% of the world's population, are important contributors to society and their families. Read More

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http://dx.doi.org/10.26442/terarkh201890614-14DOI Listing
June 2018
1 Read

Pregnancy Induced Hypertension and Associated Factors among Women Attending Delivery Service at Mizan-Tepi University Teaching Hospital, Tepi General Hospital and Gebretsadik Shawo Hospital, Southwest, Ethiopia.

Ethiop J Health Sci 2019 Jan;29(1):831-840

MizanTepi University, College of Health Science, Department of Nursing, adult Health Hursing Unit.

Background: Disorders of pregnancy induced hypertensive are a major health problem in the obstetric population as they are one of the leading causes of maternal and perinatal morbidity and mortality. The World Health Organization estimates that at least one woman dies every seven minutes from complications of hypertensive disorders of pregnancy. The objective of this study is to assess pregnancy induced hypertension and its associated factors among women attending delivery service at Mizan-Tepi University Teaching Hospital, Gebretsadikshawo Hospital and Tepi General Hospital. Read More

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http://dx.doi.org/10.4314/ejhs.v29i1.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341446PMC
January 2019
1 Read

Mood and quality of life changes in pregnancy and postpartum and the effect of a behavioral intervention targeting excess gestational weight gain in women with overweight and obesity: a parallel-arm randomized controlled pilot trial.

BMC Pregnancy Childbirth 2019 Jan 29;19(1):50. Epub 2019 Jan 29.

Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.

Background: Intensive lifestyle interventions in pregnancy have shown success in limiting gestational weight gain, but the effects on mood and quality of life in pregnancy and postpartum are less known. The purpose was to quantify changes in mental and physical quality of life and depressive symptoms across pregnancy and the postpartum period, to determine the association between gestational weight gain and change in mood and quality of life, and to assess the effect of a behavioral intervention targeting excess gestational weight gain on these outcomes.

Methods: A three group parallel-arm randomized controlled pilot trial of 54 pregnant women who were overweight or obese was conducted to test whether the SmartMoms® intervention decreased the proportion of women with excess gestational weight gain. Read More

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http://dx.doi.org/10.1186/s12884-019-2196-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352352PMC
January 2019
1 Read

Pregnancy outcomes in women with kidney transplant: Metaanalysis and systematic review.

BMC Nephrol 2019 Jan 23;20(1):24. Epub 2019 Jan 23.

Division of Neonatology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, USA.

Background: Reproductive function in women with end stage renal disease generally improves after kidney transplant. However, pregnancy remains challenging due to the risk of adverse clinical outcomes.

Methods: We searched PubMed/MEDLINE, Elsevier EMBASE, Scopus, BIOSIS Previews, ISI Science Citation Index Expanded, and the Cochrane Central Register of Controlled Trials from date of inception through August 2017 for studies reporting pregnancy with kidney transplant. Read More

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http://dx.doi.org/10.1186/s12882-019-1213-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345071PMC
January 2019
7 Reads

Gestational hypertensive disorders show unique patterns of circulatory deterioration with ongoing pregnancy.

Am J Physiol Regul Integr Comp Physiol 2019 Jan 23. Epub 2019 Jan 23.

Statistics, Hasselt University, Belgium.

A combined assessment of heart, arteries, veins and body fluid content throughout pregnancy has not yet been reported. We hypothesized that a gradual aggravation of circulatory dysfunction exists from latent to clinical phase of gestational hypertensive disease (GHD), and that pathways are unique for preeclampsia with early-onset < 34w (EPE), late-onset ≥ 34w (LPE) and gestational hypertension (GH). Women with singleton pregnancy and no known diseases were invited for a prospective, observational study and had standardized sphygmomanometric blood pressure measurement, bioimpedance body water spectrum analysis, impedance cardiography for cardiac and arterial assessment and combined Doppler-ECG of hepatic and renal interlobar veins and uterine arteries. Read More

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http://dx.doi.org/10.1152/ajpregu.00075.2018DOI Listing
January 2019
1 Read

Dialysis or a Plant-Based Diet in Advanced CKD in Pregnancy? A Case Report and Critical Appraisal of the Literature.

J Clin Med 2019 Jan 20;8(1). Epub 2019 Jan 20.

Department of Biological and Clinical Sciences, University of Torino, 10100 Torino, Italy.

Pregnancy is increasingly reported in chronic kidney disease (CKD), reflecting higher awareness, improvements in materno-foetal care, and a more flexible attitude towards "allowing" pregnancy in the advanced stages of CKD. Success is not devoid of problems and an important grey area regards the indications for starting dialysis (by urea level, clinical picture, and residual glomerular filtration rate) and for dietary management. The present case may highlight the role of plant-based diets in dietary management in pregnant CKD women, aimed at retarding dialysis needs. Read More

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http://dx.doi.org/10.3390/jcm8010123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352283PMC
January 2019
8 Reads

Prevention & control of fluorosis & linked disorders: Developments in the 21 Century - Reaching out to patients in the community & hospital settings for recovery.

Indian J Med Res 2018 Nov;148(5):539-547

Centre for Promotion of Nutrition Research and Training with special focus on North East, tribal & Inaccessible Population, Division of Nutrition, Indian Council of Medical Research (Campus II), Tuberculosis Association of India Building, New Delhi; ICMR-Desert Medicine Research Centre, Jodhpur, India.

The review on fluorosis addresses the genesis of the disease, diagnostic protocols developed, mitigation and recovery through nutritional interventions. It reveals the structural and functional damages caused to skeletal muscle and erythrocytes, leading to clinical manifestations in fluorosis. Hormonal derangements resulting in serious abnormalities in the health of children and adults are discussed. Read More

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http://www.ijmr.org.in/text.asp?2018/148/5/539/249979
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http://dx.doi.org/10.4103/ijmr.IJMR_1775_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366265PMC
November 2018
14 Reads

Acute kidney injury in pregnancy including renal disease diagnosed in pregnancy.

Best Pract Res Clin Obstet Gynaecol 2018 Dec 17. Epub 2018 Dec 17.

Department of Women and Children's Health, King's College London, London, UK.

Pregnancy-related acute kidney injury (AKI) is a rare but serious complication in high-income settings and remains an important cause of maternal and foetal morbidity and mortality in low- and middle-income settings. Hypertensive disorders of pregnancy are the leading cause of pregnancy-related AKI worldwide. In this article, we outline the epidemiology, aetiology, recognition, investigation and management of pregnancy-related AKI. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2018.12.005DOI Listing
December 2018
5 Reads

Recurrent case of pregnancy-induced atypical haemolytic uremic syndrome (P-aHUS).

BMJ Case Rep 2019 Jan 17;12(1). Epub 2019 Jan 17.

Medicine (Nephrology), Jacobi Medical Center / Albert Einstein College of Medicine, New York City, New York, USA.

Pregnancy-induced atypical haemolytic uremic syndrome (P-aHUS) is a rare condition characterised by microangiopathic haemolytic anaemia, thrombocytopenia and renal failure. It accounts for approximately 7% of total HUS cases. Here, we present a case of recurrent P-aHUS in a 25-year-old Hispanic woman. Read More

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http://dx.doi.org/10.1136/bcr-2018-226571DOI Listing
January 2019
3 Reads

[Preeclampsia - a disease of pregnant women].

Postepy Biochem 2018 12;64(4):232-229

Pracownia Białek Wiążących Wapń, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Warszawa.

Preeclampsia, also known as EPH-gestosis, is a pregnancy-specific syndrome. It affects 3-5% of pregnant women and is characterized by edemas, high blood pressure and proteinuria. Moreover, in women with preeclampsia dysfunction of many organs, such as kidney and liver, is diagnosed, while in the case of fetus growth restriction is observed. Read More

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http://dx.doi.org/10.18388/pb.2018_146DOI Listing
December 2018
4 Reads

Migration of an intrauterine device causing severe hydronephrosis progressing to renal failure: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e13872

Department of Obstetrics and Gynecology, People's Hospital of Zhengzhou University.

Rationale: Intrauterine device (IUD) is commonly used in China. Its complications include uterine perforation, IUD ectopic migration, etc. However, a migrated IUD rarely leads to renal failure. Read More

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http://dx.doi.org/10.1097/MD.0000000000013872DOI Listing
January 2019
2 Reads

Correlation analysis of levels of inflammatory cytokines and nitric oxide in peripheral blood with urine proteins and renal function in patients with gestational hypertension.

Exp Ther Med 2019 Jan 22;17(1):657-662. Epub 2018 Nov 22.

Department of Cardiac Function, Xiangyang Central Hospital (The Affiliated Hospital of Hubei University of Arts and Science) Xiangcheng, Xiangyang, Hubei 441021, P.R. China.

The aim of the study was to investigate correlations among inflammatory cytokines, nitric oxide (NO) level, urine protein, renal function and blood pressure in peripheral blood of patients with hypertensive disorder complicating pregnancy (HDCP). A total of 60 patients diagnosed with HDCP in the Obstetrics Department of Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology from May 2016 to April 2017 were selected. The patients were divided into the HDCP (n=20), mild pre-eclampsia (n=20) and severe pre-eclampsia (n=20) groups. Read More

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http://dx.doi.org/10.3892/etm.2018.7004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307447PMC
January 2019
1 Read

Maternal glucose levels during pregnancy and childhood adiposity in the Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study.

Diabetologia 2019 Jan 15. Epub 2019 Jan 15.

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.

Aims/hypothesis: Maternal type 2 diabetes during pregnancy and gestational diabetes are associated with childhood adiposity; however, associations of lower maternal glucose levels during pregnancy with childhood adiposity, independent of maternal BMI, remain less clear. The objective was to examine associations of maternal glucose levels during pregnancy with childhood adiposity in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort.

Methods: The HAPO Study was an observational epidemiological international multi-ethnic investigation that established strong associations of glucose levels during pregnancy with multiple adverse perinatal outcomes. Read More

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http://link.springer.com/10.1007/s00125-018-4809-6
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http://dx.doi.org/10.1007/s00125-018-4809-6DOI Listing
January 2019
6 Reads

Successful entecavir plus prednisolone treatment for hepatitis B virus-associated membranoproliferative glomerulonephritis: A case report.

Medicine (Baltimore) 2019 Jan;98(2):e14014

Department of Medicine Kidney Center.

Rationale: Adult-onset hepatitis B virus-associated membranoproliferative glomerulonephritis (HBV-MPGN) is generally refractory, and an effective treatment for this condition has not been established. The indications for steroids in HBV-MPGN are an important clinical concern.

Patient Concerns: A 28-year-old woman with a chronic hepatitis B virus infection developed nephrotic syndrome in her second month of pregnancy, with urinary protein levels of 3 to 10 g/d that continued into her postpartum period. Read More

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http://dx.doi.org/10.1097/MD.0000000000014014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336600PMC
January 2019
1 Read

Prenatal ultrasonography of autosomal dominant polycystic kidney disease mimicking recessive type: case series.

Pediatr Radiol 2019 Jan 10. Epub 2019 Jan 10.

Service de Radiologie, Hôpital d'Enfants Armand-Trousseau APHP, 26 avenue du Dr Arnold Netter, 75012, Paris, France.

Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited renal disease. This pathology has been increasingly diagnosed in utero and several sonographic patterns are well described in the literature.

Objective: To present a series of fetuses with an unusual imaging pattern of ADPKD, mimicking autosomal recessive polycystic kidney disease (ARPKD). Read More

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http://link.springer.com/10.1007/s00247-018-4325-3
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http://dx.doi.org/10.1007/s00247-018-4325-3DOI Listing
January 2019
13 Reads

Non-additive effects of ACVR2A in preeclampsia in a Philippine population.

BMC Pregnancy Childbirth 2019 Jan 8;19(1):11. Epub 2019 Jan 8.

National Institute of Molecular Biology and Biotechnology, National Science Complex, University of the Philippines, Diliman, 1101, Quezon City, Philippines.

Background: Multiple interrelated pathways contribute to the pathogenesis of preeclampsia, and variants in susceptibility genes may play a role among Filipinos, an ethnically distinct group with high prevalence of the disease. The objective of this study was to examine the association between variants in maternal candidate genes and the development of preeclampsia in a Philippine population.

Methods: A case-control study involving 29 single nucleotide polymorphisms (SNPs) in 21 candidate genes was conducted in 150 patients with preeclampsia (cases) and 175 women with uncomplicated normal pregnancies (controls). Read More

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http://dx.doi.org/10.1186/s12884-018-2152-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323705PMC
January 2019
4 Reads

Cystatin C as a novel predictor of preterm labor in severe preeclampsia.

Kidney Res Clin Pract 2018 Dec 31;37(4):338-346. Epub 2018 Dec 31.

Department of Internal Medicine, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand.

Background: The most common cause of acute kidney injury (AKI) in pregnancy is preeclampsia. Serum cystatin C (CysC) is a potential biomarker of early kidney damage as its levels are not disturbed by volume status changes in pregnancy, and serum CysC levels could serve as a replacement for conventionally used creatinine. In this study, we investigated the serum levels of CysC in severe preeclampsia cases and the associations between CysC levels and poor obstetric outcomes. Read More

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http://www.krcp-ksn.org/journal/view.html?doi=10.23876/j.krc
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http://dx.doi.org/10.23876/j.krcp.18.0080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312773PMC
December 2018
2 Reads

A rare deep intronic mutation of PKHD1 gene, c.8798-459 C > A, causes autosomal recessive polycystic kidney disease by pseudoexon activation.

J Hum Genet 2019 Mar 7;64(3):207-214. Epub 2019 Jan 7.

Reproductive and Genetic Hospital of Citic-Xiangya, Changsha, Hunan, 410078, China.

Autosomal recessive polycystic kidney disease (ARPKD), is a rare hepatorenal fibrocystic disorder primarily associated with progressive growth of multiple cysts in the kidneys causing progressive loss of renal function. The disease is linked to mutations in the PKHD1 gene. In this study, we describe the gene diagnosis and prenatal diagnosis for a consanguineous family with two fetuses diagnosed with polycystic kidney disease by fetal sonography during the pregnancy. Read More

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http://www.nature.com/articles/s10038-018-0550-8
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http://dx.doi.org/10.1038/s10038-018-0550-8DOI Listing
March 2019
7 Reads

Superimposed Preeclampsia Exacerbates Postpartum Renal Injury Despite Lack of Long-Term Blood Pressure Difference in the Dahl Salt-Sensitive Rat.

Hypertension 2019 Mar;73(3):650-658

From the Departments of Pharmacology and Toxicology (H.R.T., M.R.G., S.P.D., J.M.S.), University of Mississippi Medical Center, Jackson.

Preeclampsia results in increased susceptibility to hypertension and chronic kidney disease postpartum; however, the mechanisms responsible for disease progression in these women remain unknown. The purpose of this study was to test the hypothesis that 2 mechanisms contribute to the link between the maternal syndrome of preeclampsia and the increased postpartum risk of cardiovascular and renal disease: (1) increased T cells in the kidney and (2) a decreased NO:ET-1 (endothelin-1) ratio. Dahl S rats (a previously characterized model of preeclampsia superimposed on chronic hypertension) who experienced 2 pregnancies and virgin littermate controls were studied at 6 months of age. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
Publisher Site
http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374193PMC
March 2019
3 Reads

Dialysis in pregnancy.

Best Pract Res Clin Obstet Gynaecol 2018 Nov 27. Epub 2018 Nov 27.

UNESP Sao Paulo State University, Brazil.

Although kidney disease impacts on fertility, increasing numbers of pregnancies are reported in women on dialysis. Despite a trend of increasing live birth rates over recent decades, pregnancies on dialysis remain high risk with increased rates of adverse pregnancy outcomes including pregnancy loss, pre-eclampsia, pre-term delivery, low birth weight and higher levels of neonatal care. This article describes the prevalence of dialysis and pregnancy in women of childbearing age, with relevant information regarding the effects of end-stage renal disease on fertility in women. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2018.11.007DOI Listing
November 2018
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[Prenatal care in patients with renal disease].

Dtsch Med Wochenschr 2019 Jan 2;144(1):35-38. Epub 2019 Jan 2.

Universitätsfrauenklinik Freiburg.

History And Clinical Findings:  We report of three pregnancies, two with renal insufficiency and one with a history of renal transplantation. Pat.1 is a 32y at 20 weeks of gestation with acute renal failure, nephrotic syndrome and history of familial Mediterranean fever. Read More

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http://dx.doi.org/10.1055/a-0794-8391DOI Listing
January 2019
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The patient experience of kidney disease and pregnancy.

Best Pract Res Clin Obstet Gynaecol 2018 Dec 12. Epub 2018 Dec 12.

Sydney School of Public Health, The University of Sydney, New South Wales, 2006, Australia; Centre for Kidney Research, The Children's Hospital at Westmead, New South Wales, 2145, Australia.

Achieving parenthood is often a priority and goal for women with chronic kidney disease (CKD). It can be challenging due to medical and emotional complexities around pregnancy planning and care, increased risk of adverse maternal and fetal outcomes, fears about medications such as immunosuppressants and fetal harm, and concerns regarding the impact of pregnancy on women's kidney health. Navigating the pathways for shared decision-making regarding parenthood requires an understanding of the patient's experiences, values, priorities, and needs. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2018.12.003DOI Listing
December 2018
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Renal Complications in Pregnancy Preceding Glomerulonephropathy Diagnosis.

Kidney Int Rep 2019 Jan 25;4(1):159-162. Epub 2018 Oct 25.

Division of Nephrology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ekir.2018.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308828PMC
January 2019
3 Reads

[Epidemiology and pathophysiology of post-pregnancy osteoporosis.]

Clin Calcium 2019 ;29(1):39-45

Niigata City General Hospital, Niigata, Japan.

Post-pregnancy osteoporosis is a rare condition with little known pathophysiology. Most cases are diagnosed in the late stage of pregnancy or in the post partum while breastfeeding, particularly in first pregnancy. Non-traumatic vertebral fragility fractures are most commonly observed and characterized by prolonged severe pain and functional limitations. Read More

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http://dx.doi.org/CliCa19013945DOI Listing
January 2019
11 Reads

Azathioprine-induced Agranulocytosis and Severe Alopecia After Kidney Transplantation Associated With a NUDT15 Polymorphism: A Case Report.

Transplant Proc 2018 Dec 18;50(10):3925-3927. Epub 2018 Apr 18.

Division of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan. Electronic address:

Background: Azathioprine (AZA) is the drug recommended for the continuation of immunosuppressive treatment after renal transplant in women during pregnancy.

Case Report: A 37-year-old Japanese female developed agranulocytosis and severe alopecia after initiation of AZA (50 mg), used as an alternative to mycophenolate mofetil (MMF, 1000 mg) therapy in anticipation of a planned pregnancy. Within 4 days of the initiation of AZA therapy, the patient developed a high fever, leucopenia, and cranial alopecia. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.039DOI Listing
December 2018
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Vitamin D's role in health and disease: How does the present inform our understanding of the past?

Int J Paleopathol 2018 12 28;23:6-14. Epub 2017 Nov 28.

Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. Electronic address:

While the role of vitamin D in supporting bone homeostasis during growth and maintenance is well substantiated, emerging evidence from ecological and observational studies suggests that a deficiency of vitamin D is associated with some cancers, immune disorders, cardiovascular disease, abnormal glucose metabolism, and neurodegenerative diseases. Biological plausibility for extraskeletal functions originated with the discovery of the vitamin D receptor in many body tissues and knowledge that the conversion of 25-hydroxyvitamin D (25(OH)D) to its active metabolite 1,25(OH)D occurs in many cell types in addition to the kidney. The association of vitamin D status in humans as an etiological factor in developmental programming of bone, in some chronic diseases, and in all-cause mortality, in addition to skeletal morbidity, is supported by some but not all observational studies and randomized controlled trials. Read More

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http://dx.doi.org/10.1016/j.ijpp.2017.11.005DOI Listing
December 2018
1 Read

[Hyperhomocysteinemia and kidney diseases].

Sheng Li Xue Bao 2018 Dec;70(6):607-611

Advanced Institute of Medical Sciences, Dalian Medical University, Dalian 116044, China.

Homocysteine (Hcy) is an intermediate metabolite of methionine metabolism. Hyperhomocysteinemia (HHcy) is defined as a condition characterized by plasma Hcy level above 16 μmol/L which can result from abnormal Hcy metabolism. HHcy has been confirmed to be related to cardio-cerebrovascular disease, peripheral vascular disorders, neurodegenerative diseases, diabetes, pregnancy-induced hypertension syndrome, liver cirrhosis and kidney diseases. Read More

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December 2018
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Successful pregnancy and delivery in uremic patients with maintenance hemodialysis: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13614

Department of Nephrology.

Rationale: It is reported that successful pregnancies in dialyzed uremic women are rare. Over the past years, despite advances in clinical management and technology in dialysis for pregnancy in patients receiving maintenance hemodialysis, uremia remains a high risk factor for adverse outcomes in mother and fetus.

Patient Concerns: In this article, we present a case of pregnancy in a 34-year-old uremic woman on dialysis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320043PMC
December 2018
1 Read

Primary hypophysitis and other autoimmune disorders of the sellar and suprasellar regions.

Rev Endocr Metab Disord 2018 Dec;19(4):335-347

Medicover GmbH, Berlin/Hannover, Germany.

The pituitary gland and the hypothalamus can be affected by autoimmune-mediated structural and functional disruption. These autoimmune-mediated diseases occur more commonly in females and are often found during pregnancy or in the post-partum period. Autoimmune diseases can either affect parts of the pituitary or hypothalamus, or can involve both sellar and suprasellar structures. Read More

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http://link.springer.com/10.1007/s11154-018-9480-1
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http://dx.doi.org/10.1007/s11154-018-9480-1DOI Listing
December 2018
12 Reads

Urinary strips for proteins: easy to do but difficult to read!

Ann Biol Clin (Paris) 2018 Dec;76(6):617-626

Université de Liège, Service de chimie médicale, CHU Sart Tilman (CHU ULg), Liège, Belgique.

Urine is an easily accessible biological fluid. This availability makes it tempting for a direct analysis of urinary parameters by physicians. Urinary proteins, that are interesting markers for several pathologies, are detected by urinary strips, rapidly and at a low cost. Read More

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http://dx.doi.org/10.1684/abc.2018.1388DOI Listing
December 2018
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Management and pregnancy outcomes of women with GCK-MODY enrolled in the US Monogenic Diabetes Registry.

Acta Diabetol 2018 Dec 11. Epub 2018 Dec 11.

Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Kovler Diabetes Center, University of Chicago, 5841 South Maryland Ave., MC 1027, Chicago, IL, 60637, USA.

Aims: GCK-MODY is characterized by mild hyperglycemia. Treatment is not required outside of pregnancy. During pregnancy, insulin treatment is recommended if second trimester fetal ultrasound monitoring shows macrosomia, suggesting the fetus has not inherited the GCK gene. Read More

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http://dx.doi.org/10.1007/s00592-018-1267-zDOI Listing
December 2018
4 Reads

Embryonal Origin of Metanephric Adenoma and its Differential Diagnosis.

Anticancer Res 2018 Dec;38(12):6663-6667

Department of Urology, Medical School, University of Pecs, Pecs, Hungary

Background/aim: The association of Wilms' tumor (WT), papillary renal cell tumor (PRCT) and mucinous tubular and spindle cell carcinoma (MTSCC) with embryonal rests has already been documented, but the cellular origin of metanephric adenoma (MA) is not yet known. The aim of this study was to understand their developmental evolution and find diagnostic markers.

Materials And Methods: CD57, KRT7, AMACR, SCEL, WT1 and CDH17 expression was analysed by immunohistochemistry in the four types of tumors and the associated pre-neoplastic lesions. Read More

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http://dx.doi.org/10.21873/anticanres.13033DOI Listing
December 2018
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The toxicology of air pollution predicts its epidemiology.

Inhal Toxicol 2018 Aug - Aug;30(9-10):327-334. Epub 2018 Dec 5.

a The National Health and Environmental Effects Research Laboratory , Environmental Protection Agency , Chapel Hill , NC , USA.

The epidemiologic investigation has successively delineated associations of air pollution exposure with non-malignant and malignant lung disease, cardiovascular disease, cerebrovascular disease, pregnancy outcomes, perinatal effects and other extra-pulmonary disease including diabetes. Defining these relationships between air pollution exposure and human health closely parallels results of an earlier epidemiologic investigation into cigarette smoking and environmental tobacco smoke (ETS), two other particle-related exposures. Humic-like substances (HULIS) have been identified as a chemical component common to cigarette smoke and air pollution particles. Read More

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https://www.tandfonline.com/doi/full/10.1080/08958378.2018.1
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http://dx.doi.org/10.1080/08958378.2018.1530316DOI Listing
December 2018
29 Reads

Post-partum catastrophic antiphospholipid syndrome presenting with shock and digital ischaemia - A diagnostic and management challenge.

J Intensive Care Soc 2018 Nov 19;19(4):357-364. Epub 2018 Mar 19.

Intensive Care Medicine, Nepean Hospital, Kingswood, NSW, Australia.

Catastrophic antiphospholipid syndrome is a rare multisystem autoimmune condition characterised by rapid development of widespread thrombotic disease and subsequent multi-organ failure. It is the most severe complication of antiphospholipid syndrome, carrying significant morbidity and mortality. We report a patient with post-partum catastrophic antiphospholipid syndrome with cardiac, hepatic, renal and cutaneous manifestations. Read More

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http://dx.doi.org/10.1177/1751143718762343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259081PMC
November 2018
2 Reads