17,578 results match your criteria Renal Disease and Pregnancy


Effect of standard dose paracetamol versus placebo as antipyretic therapy on liver injury in adult dengue infection: a multicentre randomised controlled trial.

Lancet Glob Health 2019 May;7(5):e664-e670

Division of Infectious Diseases, Phramongkutklao Hospital, Bangkok, Thailand.

Background: Dengue is a common cause of acute liver failure in tropical countries. Paracetamol is the recommended antipyretic for dengue. Related observational studies in dengue have suggested that excessive paracetamol intake is related to hepatic injury. Read More

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http://dx.doi.org/10.1016/S2214-109X(19)30032-4DOI Listing

Today's vaccination policies in Italy: The National Plan for Vaccine Prevention 2017-2019 and the Law 119/2017 on the mandatory vaccinations.

Ann Ig 2019 Mar-Apr;31(2 Supple 1):54-64

Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, Italy.

The National Plan for Vaccine Prevention 2017-2019 has expanded the vaccination offer including new vaccines, enlarging the target population and introducing for the first time in Italy a life-course approach to vaccination. A "lifetime immunization schedule" is aimed to reduce the burden and the related costs of vaccine-preventable diseases through effective vaccination programs. However, to counteract the national steady downward trend in the uptake of vaccinations that caused a drop of the vaccination coverage below the 95% threshold to allow herd immunity, it was decided to make 10 vaccinations mandatory by the law 119/2017. Read More

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http://dx.doi.org/10.7416/ai.2019.2277DOI Listing
April 2019
1 Read

Renal histopathology of prolonged acute kidney injury in HELLP syndrome: a case series and literature review.

Int Urol Nephrol 2019 Apr 15. Epub 2019 Apr 15.

Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuifuyuan 1, Wangfujing, Beijing, 100730, China.

Purpose: Acute kidney injury (AKI) is a severe complication of hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. However, renal pathological investigation of AKI in this syndrome has rarely been reported. We aimed to evaluate the renal pathological changes of persistent AKI and its relationship with renal outcomes in HELLP syndrome. Read More

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http://dx.doi.org/10.1007/s11255-019-02135-zDOI Listing
April 2019
1 Read

[HELLP syndrome and hemolytic uremic syndrome during pregnancy: two disease entities, same causation. Case report and literature review].

G Ital Nefrol 2019 Apr;36(2)

Centro per la Cura e lo Studio della Sindrome Emolitico-Uremica. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano.

Thrombotic microangiopathies (TMA) are a group of diseases that can complicate pregnancy and threaten the lives of both the mother and the fetus. Several conditions can lead to TMA, including thrombotic thrombocytopenic purpura (TTP), HELLP syndrome and hemolytic uremic syndrome (HUS). We describe the case of a 39-year-old woman who presented a HELLP syndrome in the immediate postpartum period. Read More

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April 2019
3 Reads

The Spectrum of Adverse Pregnancy Outcomes Based on Kidney Disease Diagnoses: A 20-Year Population Study.

Am J Nephrol 2019 Apr 12;49(5):400-409. Epub 2019 Apr 12.

Central and Northern Adelaide Renal and Transplantation Services (CNARTS), Royal Adelaide Hospital, Adelaide, South Australia, Australia,

Background And Objectives: Kidney disorders in pregnancy may be under-recognized and have variable impact on outcomes depending on diagnosis. Population-level data are limited, particularly for Australia, and comparison of impact of different kidney disorders on pregnancy has rarely been assessed. This study examined the prevalence and outcomes of varied kidney disorders using population-level perinatal data from a large cohort. Read More

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http://dx.doi.org/10.1159/000499965DOI Listing
April 2019
1 Read

[In-hospital management of acute complicated urinary tract infections].

Nephrol Ther 2019 Apr;15 Suppl 1:S27-S32

Unité de bactériologie, groupe hospitalier Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France; Université Paris-Est-Créteil-Val-de-Marne, avenue du Général-de-Gaulle, 94010 Créteil cedex, France.

Upper tract urinary tract infections that require hospitalization have been the focus of national recommendations in 2018 by the French society of infectious diseases (Spilf). We here propose to discuss several complex-challenging situations: severe infection with sepsis, pyelonephritis in the pregnant woman, management of infections involving multiresistant bacteria and infection in polycystic kidney disease. Read More

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http://dx.doi.org/10.1016/j.nephro.2019.02.002DOI Listing
April 2019
1 Read

Outcome of fetuses with lower urinary tract obstruction and normal amniotic fluid volume in the second trimester of pregnancy: a single center experience.

Ultrasound Obstet Gynecol 2019 Apr 11. Epub 2019 Apr 11.

Department of Obstetrics and Gynecology, Baylor College of Medicine, and Texas Children's Fetal Center, Houston, Texas, USA.

Objective: Congenital lower urinary tract obstruction (LUTO) is a rare condition with high perinatal mortality and morbidity when associated with severe oligohydramnios or anhydramnios in the second trimester of pregnancy. Severe pulmonary hypoplasia and end-stage renal disease are the underlying causes of poor neonatal outcomes in these cases. However, little is known about the subset of fetal LUTO with a normal amount of amniotic fluid at mid-gestation. Read More

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http://dx.doi.org/10.1002/uog.20288DOI Listing
April 2019
2 Reads

The Relationship between Maternal Global Nutrient Restriction during Pregnancy and Offspring Kidney Structure and Function:A Systematic Review of Animal studies.

Am J Physiol Renal Physiol 2019 Apr 10. Epub 2019 Apr 10.

School of Biomedical Sciences and Pharmacy, University of Newcastle, Australia.

Background: Maternal under-nutrition during pregnancy is prevalent across the globe, and the origins of many chronic diseases can be traced back to in utero conditions. This systematic review considers the current evidence in animal models regarding the relationship between maternal global nutrient restriction during pregnancy and offspring kidney structure and function.

Methods: CINAHL, Cochrane, EMBASE, MEDLINE and Scopus were searched to November 2017. Read More

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http://dx.doi.org/10.1152/ajprenal.00082.2019DOI Listing
April 2019
2 Reads

Delayed Initiation of Hemodialysis in Pregnant Women with Chronic Kidney Disease: Logistical Problems Impact Clinical Outcomes. An Experience from an Emerging Country.

J Clin Med 2019 Apr 8;8(4). Epub 2019 Apr 8.

Unidad de Investigación Médica en Enfermedades Nefrológicas, CMN Siglo XXI, 06720 CdMx, México.

Background: Chronic kidney disease (CKD) is associated with reduction of fertility and increased complications during pregnancy. The aim of this work is to analyze the clinical outcomes and risk factors in pregnant women who needed to start dialysis with different schedules in a public hospital in Mexico City, with particular attention on the interference of social and cultural elements as well as resource limitations.

Material And Methods: CKD women who needed dialysis in pregnancy over the period 2002⁻2014 and had with complete demographic and outcome data were included in this retrospective study. Read More

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http://dx.doi.org/10.3390/jcm8040475DOI Listing

Role of environmental factors & oxidative stress with respect to fertilization outcome.

Indian J Med Res 2018 Dec;148(Supplement):S125-S133

Division of Reproductive and Cytotoxicology, ICMR-National Institute of Occupational Health, Ahmedabad, India.

Background & Objectives: Oxidative stress, lifestyle factors as also exposure to certain environmental factors are known to affect the fertility status in human beings. The aim of this study was to evaluate the role of OS and lifestyle and environmental factors affecting IVF outcome.

Methods: A total of 253 couples were included, and biological samples such as blood, follicular fluid (FF), cumulus cells and semen were collected. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_1864_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469366PMC
December 2018
1 Read
1.661 Impact Factor

Calprotectin in pregnancy and pregnancy-associated diseases: a systematic review and prospective cohort study.

Arch Gynecol Obstet 2019 Apr 5. Epub 2019 Apr 5.

Department of Obstetrics and Gynecology, Ruhr-Universität Bochum - Marien Hospital Herne, Hölkeskampring 40, 44625, Herne, Germany.

Purpose: Calprotectin, a marker of acute and chronic inflammation, may play a role in pregnancy-associated disorders. We aimed to summarize available clinical data on calprotectin in pregnancy and to establish normal values of calprotectin during the course of pregnancy.

Methods: We performed a systematic review of the databases PubMed and Cochrane Central Register of Controlled Trials to identify experimental and clinical evidence assessing the role of calprotectin in pregnancy. Read More

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http://dx.doi.org/10.1007/s00404-019-05134-8DOI Listing
April 2019
2 Reads

[Genetic testing and pregnancy outcome of 337 fetuses with urinary system anomalies].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2019 Apr;36(4):306-309

Maternal and Child Health Care Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi 530003, China. Email:

Objective: To explore the genetic basis and pregnancy outcome of fetuses with urinary system anomalies.

Methods: Ultrasonographic features, genetic testing and pregnancy outcomes of 337 fetuses with urinary system anomalies identified by prenatal ultrasonograhy were collected for analysis.

Results: Ultrasonographic features of the fetuses were mainly characterized by hydronephrosis or hydronephrosis, polycystic kidney disease, and renal dysplasia. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2019.04.004DOI Listing
April 2019
4 Reads

A successful pregnancy in a patient with secondary hypertension caused by adrenal adenoma: a case report.

BMC Pregnancy Childbirth 2019 Apr 3;19(1):116. Epub 2019 Apr 3.

Department of cardiology, West China Hospital, Sichuan University, Chengdu, China.

Background: Secondary hypertension is a rare complication in pregnancy that causes poor outcomes, such as preeclampsia, premature delivery, intrauterine growth retardation, stillbirths, spontaneous abortion or intrauterine death. Cushing's disease caused by an adrenal adenoma is rare during pregnancy and may be overlooked by obstetricians and physicians, but can lead to hypertension, diabetes mellitus and an increased risk of fetal and maternal morbidity. Approximately 200 cases have been reported in the literature. Read More

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http://dx.doi.org/10.1186/s12884-019-2262-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448298PMC
April 2019
2 Reads

[Potential value of placental angiogenic factors as biomarkers in preeclampsia for clinical physicians].

Nephrol Ther 2019 Mar 30. Epub 2019 Mar 30.

Service de néphrologie et de dialyse de l'hôpital Américain de Paris, 63, boulevard Victor Hugo, 92200 Neuilly-sur-Seine, France; Service de néphrologie et de dialyse, hôpital Bichat, 46, rue Henri Huchard, 75018 Paris, France.

The role of angiogenic factors in the onset of clinical manifestations of preeclampsia was demonstrated in 2003 by the implication of sFlt-1, PlGF and VEGF, and in 2006 by the implication of soluble endoglin. Placental ischemia and inflammation observed in preeclampsia alter both the production and progression of angiogenic factors during pregnancy. During the first trimester, the combination of PlGF with clinical, biophysical and biological factors results in a better test than the conventional one. Read More

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http://dx.doi.org/10.1016/j.nephro.2018.10.005DOI Listing
March 2019
3 Reads

Switching Between β-Blockers: An Empiric Tool for the Cardiovascular Practitioner.

Can J Cardiol 2019 Apr 31;35(4):539-543. Epub 2019 Jan 31.

Division of Cardiology, St Paul's Hospital and Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

β-Blockers are a cornerstone of therapy for cardiovascular disease, but their clinical benefits are not consistent across the class and specific agents are preferred for certain indications. Further, when prescribed, a patient's clinical status might change, requiring the cardiologist to switch to an alternate agent. Examples of such scenarios include the development or a worsening of chronic noncardiac diseases (eg, hyperthyroidism, renal failure), new cardiac-related disease (eg, heart failure, atrial fibrillation), or practical/safety issues (eg, pregnancy, cost, side effects). Read More

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http://dx.doi.org/10.1016/j.cjca.2019.01.013DOI Listing
April 2019
3 Reads

Renal disease in pregnancy: Fetal, neonatal and long-term outcomes.

Best Pract Res Clin Obstet Gynaecol 2019 Feb 15. Epub 2019 Feb 15.

Department of Paediatric Nephrology, Evelina London Children's Hospital, Guys & St Thomas NHS Foundation Trust, Westminster Bridge Road, London SE1 7EH, UK; Kings College London, UK. Electronic address:

Renal disease in women of childbearing age is estimated to be approximately 3%; consequently, renal disease is not an uncommon comorbidity in pregnancy. There has been considerable evidence published over the last 20 years to suggest that renal disease in pregnancy is associated with higher maternal, fetal, and offspring morbidity. Studies published are largely heterogeneous; include unmatched cohort studies; and focus on early neonatal outcomes such as prematurity, small for gestational age, and neonatal unit admission. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2019.01.018DOI Listing
February 2019
6 Reads

Renal Consequences of Gestational Diabetes Mellitus in Term Neonates: A Multidisciplinary Approach to the DOHaD Perspective in the Prevention and Early Recognition of Neonates of GDM Mothers at Risk of Hypertension and Chronic Renal Diseases in Later Life.

J Clin Med 2019 Mar 28;8(4). Epub 2019 Mar 28.

Department of Surgical and Biomedical Sciences, Section of Obstetrics and Gynecology, University of Perugia, 06132 Perugia, Italy.

Fetal exposure to gestational diabetes mellitus (GDM) seems to stimulate a negative impact on the kidneys. Renal volumes and urinary biomarkers of renal function and tubular impairment and injury were evaluated in 30⁻40-day old newborns of GDM mothers ( = 139) who needed insulin therapy during pregnancy. We found that neonates of mothers who maintained strict control over normoglycemia ( = 65) during pregnancy and fulfilled the other criteria of the GDM management program showed no differences compared to control ( = 55). Read More

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http://dx.doi.org/10.3390/jcm8040429DOI Listing
March 2019
2 Reads

The correlation between AGT gene polymorphism and neonatal hypoxic-ischemic encephalopathy (HIE).

Eur Rev Med Pharmacol Sci 2019 Mar;23(5):2194-2199

Department of Disease Control, Zhengzhou University Affiliated Children's Hospital, Henan Children's Hospital Hospital, Zhengzhou Children's Hospital, Zhengzhou, China.

Objective: To explore the correlation between the rs2067853 polymorphism in angiotensinogen (AGT) gene and neonatal hypoxic-ischemic encephalopathy (HIE).

Patients And Methods: A total of 96 neonatal patients with HIE and 123 healthy neonates were selected. General clinical data were collected and TaqMan-MGB probe method was adopted to detect the rs2067853 polymorphism in angiotensinogen (AGT) gene. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17266DOI Listing
March 2019
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The Extended Use of Eculizumab in Pregnancy and Complement Activation⁻Associated Diseases Affecting Maternal, Fetal and Neonatal Kidneys-The Future Is Now?

J Clin Med 2019 Mar 24;8(3). Epub 2019 Mar 24.

Department of Obstetrics and Gynecology, Helsinki University and Helsinki University Hospital, Haartmaninkatu 2, 00290 Helsinki, Finland.

Excessive complement activation is involved in the pathogenesis of many diseases and the kidney is an organ with particular susceptibility to complement-mediated injury. Apart from paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS), there are several other diseases with clear evidence of complement activation affecting both maternal and fetal kidneys during pregnancy and causing long-term adverse outcomes. Several novel drugs have been recently developed for blocking the complement cascade, including purified plasma proteins, new monoclonal antibodies, recombinant proteins, small molecules, and small interfering RNA agents. Read More

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https://www.mdpi.com/2077-0383/8/3/407
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http://dx.doi.org/10.3390/jcm8030407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463259PMC
March 2019
7 Reads

Microbiota of newborn meconium is associated with maternal anxiety experienced during pregnancy.

Dev Psychobiol 2019 Mar 25. Epub 2019 Mar 25.

Department of Psychology, Queens College, City University of New York, New York, New York.

Little is known about whether a mother's psychological state during pregnancy influences her offspring's microbiome. This study examined whether maternal anxiety, depression, and stress during pregnancy is associated with the diversity of meconium microbiome, the first internal discharge, in 75 newborns from an existing birth cohort study. The meconium microbiome was profiled using multibarcode16S rRNA sequencing at V3-V4 hypervariable region followed by taxonomic assignment to the green gene 16S references at 97% similarity and diversity analysis at the genus level. Read More

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http://dx.doi.org/10.1002/dev.21837DOI Listing
March 2019
1 Read

Randomized Controlled Trial of Home-Based Lifestyle Therapy on Postpartum Weight in Underserved Women with Overweight or Obesity.

Obesity (Silver Spring) 2019 Apr;27(4):535-541

Center for Human Nutrition, Washington University in St. Louis, St. Louis, Missouri, USA.

Objective: This study aimed to assess the efficacy of a home-based lifestyle intervention delivered through Parents as Teachers (PAT), a national home-visiting organization, designed to minimize excessive weight gain through 12 months post partum in socioeconomically disadvantaged (SED) African American women with overweight or obesity.

Methods: This randomized controlled trial was conducted at a single center as part of the Lifestyle Interventions for Expectant Moms (LIFE-Moms) consortium. Analysis was conducted with 185 SED African American women (BMI 25. Read More

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http://dx.doi.org/10.1002/oby.22413DOI Listing
April 2019
2 Reads

Successful pregnancy in a recipient of an ABO-incompatible renal allograft.

Obstet Med 2019 Mar 7;12(1):42-44. Epub 2018 Mar 7.

Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA, Australia.

Kidney transplantation restores fertility in patients with end-stage renal disease, with many successful pregnancies after kidney transplantation being reported. , there are little data regarding pregnancy in women transplanted under modern-era desensitisation protocols that utilise rituximab, plasma exchange and intravenous immunoglobulin, including ABO-incompatible transplants. Pregnancies in ABO-incompatible recipients can pose new challenges from an immunological perspective. Read More

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http://journals.sagepub.com/doi/10.1177/1753495X17745390
Publisher Site
http://dx.doi.org/10.1177/1753495X17745390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416689PMC
March 2019
2 Reads

Use of whole exome sequencing in the NICU: Case of an extremely low birth weight infant with syndromic features.

Mol Cell Probes 2019 Mar 15. Epub 2019 Mar 15.

University of Cologne, Medical Faculty and University Hospital, Department of Pediatrics, Division of Pediatric Neurology, Germany; University of Cologne, Medical Faculty, Center for Molecular Medicine Cologne (CMMC), Germany. Electronic address:

Single gene (Mendelian) disorders are one of the leading causes of neonatal morbidity and mortality. However, in the setting of preterm birth phenotypic features of genetic diseases are often undifferentiated and are clinically very difficult to interpret based on the wide range of differential diagnoses. We report an extremely low birth weight infant (ELBW) born prematurely at 23 + 0 gestational weeks after twin pregnancy with a novel clinical manifestation with persistent hyperglycaemia as well as the known manifestations of disease-associated hypokinesia, renal salt wasting, and multifocal atrial tachycardia. Read More

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http://dx.doi.org/10.1016/j.mcp.2019.03.002DOI Listing
March 2019
2 Reads

Lower free triiodothyronine levels within the reference range are associated with higher cardiovascular mortality: An analysis of the NHANES.

Int J Cardiol 2019 Jun 6;285:115-120. Epub 2019 Mar 6.

Departamento de Cirurgia e Fisiologia, Unidade de Investigação Cardiovascular, Faculdade de Medicina, Universidade do Porto, Porto, Portugal. Electronic address:

Background: Thyroid hormones play a central role in cardiovascular homeostasis. Lower free triiodothyronine (FT3) levels have been associated with worse prognosis in several conditions. However, contrary to thyrotropin (TSH) and free thyroxine (FT4), the role of FT3 in morbidity and mortality in the general population remains uncertain. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.03.009DOI Listing
June 2019
1 Read

Therapeutic Problems and Pregnancy in a Patient With Infantile Nephropathic Cystinosis: A Case Report.

Transplant Proc 2019 Mar 3;51(2):545-547. Epub 2019 Jan 3.

Department of Transplantation Medicine, Nephrology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.

Background: Cystinosis is a rare genetic disorder characterized by the abnormal accumulation of cystine in the lysosomes of various tissues and organs leading to their dysfunction. The most common type is the infantile nephropathic cystinosis which without treatment leads to renal failure and before the introduction of cysteamine was the cause of death before puberty.

Case Presentation: A 27-year-old female patient with infantile cystinosis developed end-stage renal disease at the age of 10. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.12.026DOI Listing
March 2019
2 Reads

Relationship of Postpartum Levels of Cystatin and High-Sensitivity C-Reactive Protein and Duration of Lactation in Mothers with Previous Gestational Hypertension or Preeclampsia.

Breastfeed Med 2019 Mar 15. Epub 2019 Mar 15.

5 Department of General Internal Medicine, University of California Davis, Sacramento, California.

Background: Women with hypertensive disorders of pregnancy are at increased risk of cardiovascular disease in later life. We sought to determine the association between lactation and markers of maternal cardiovascular health among postpartum women with and without hypertensive disorders of pregnancy via measures of inflammation (high-sensitivity C-reactive protein [hsCRP]) and renal function (cystatin C).

Methods: This prospective cohort study enrolled primarily overweight and obese women during early pregnancy. Read More

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http://dx.doi.org/10.1089/bfm.2018.0153DOI Listing
March 2019
1 Read

Etiology and Outcomes of Thrombotic Microangiopathies.

Clin J Am Soc Nephrol 2019 Apr 12;14(4):557-566. Epub 2019 Mar 12.

Service de Néphrologie-hypertension, Dialyses, Transplantation Rénale, Hôpital Bretonneau et hôpital Clocheville,

Background And Objectives: Thrombotic microangiopathies constitute a diagnostic and therapeutic challenge. Secondary thrombotic microangiopathies are less characterized than primary thrombotic microangiopathies (thrombotic thrombocytopenic purpura and atypical hemolytic and uremic syndrome). The relative frequencies and outcomes of secondary and primary thrombotic microangiopathies are unknown. Read More

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http://dx.doi.org/10.2215/CJN.11470918DOI Listing
April 2019
3 Reads

Clinical and Laboratory Features of Patients with Acquired Thrombotic Thrombocytopaenic Purpura: Fourteen Years of the Milan TTP Registry.

Thromb Haemost 2019 Mar 12. Epub 2019 Mar 12.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione Luigi Villa, Milan, Italy.

Acquired thrombotic thrombocytopaenic purpura (TTP) is a rare thrombotic microangiopathy caused by the immune-mediated severe deficiency of ADAMTS13. We hereby report the demographic and disease-related data of acquired TTP patients recorded in the Milan TTP Registry (www.ttpdatabase. Read More

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http://dx.doi.org/10.1055/s-0039-1679907DOI Listing
March 2019
2 Reads

Urinary Metabolites Altered during the Third Trimester in Pregnancies Complicated by Gestational Diabetes Mellitus: Relationship with Potential Upcoming Metabolic Disorders.

Int J Mol Sci 2019 Mar 8;20(5). Epub 2019 Mar 8.

Gynecology and Obstetrics Division, Hospital Central "Dr. Ignacio Morones Prieto",7800 San Luis Potosí, Mexico.

Gestational diabetes mellitus (GDM) is a disorder in pregnancy with highest impact in the future life of both mother and newborn. Increasing incidence, economic impact, and potential for severe GDM-related pregnancy complications are some factors that have motivated the deep study of physiopathology, risk factors for developing GDM, and potential biomarkers for its diagnosis. In the present pilot study, we analyzed the urinary metabolome profile of GDM patients in the 3rd trimester of pregnancy, when GDM is already established and the patients are under dietary and pharmacological control. Read More

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http://dx.doi.org/10.3390/ijms20051186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429483PMC
March 2019
3 Reads

Pregnancy in human IAPP transgenic mice recapitulates beta cell stress in type 2 diabetes.

Diabetologia 2019 Mar 9. Epub 2019 Mar 9.

Larry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, 32-150 CHS, Los Angeles, CA, 90095-7073, USA.

Aims/hypothesis: Islet amyloid polypeptide (IAPP) misfolding and toxic oligomers contribute to beta cell loss and stress in type 2 diabetes. Pregnancy-related diabetes predicts subsequent risk for type 2 diabetes but little is known about the impact of pregnancy on beta cell mass, turnover and stress. Availability of human pancreas tissue in pregnancy is limited and most widely used mouse models of type 2 diabetes do not develop pregnancy-related diabetes, possibly because rodent IAPP is not prone to form toxic oligomers. Read More

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http://dx.doi.org/10.1007/s00125-019-4843-zDOI Listing
March 2019
2 Reads

Calcium intake in high-risk pregnant women assisted in a high-complexity hospital.

Mol Biol Rep 2019 Mar 7. Epub 2019 Mar 7.

Departamento de Biociências, Silva Jardim, 136. Laboratório de Nutrição e Fisiologia Endócrina, Universidade Federal de São Paulo, 311, 3° andar, Vila Mathias, Santos, SP, Brazil.

Pregnancy is characterized by physiological changes. One of these changes involves calcium. During this period, an increased in calcium excretion occurs as well as an increased intestinal absorption and renal reabsorption, so that the adequate growth and development of the fetus can happen. Read More

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http://dx.doi.org/10.1007/s11033-019-04731-9DOI Listing
March 2019
2 Reads

The platelet-derived growth factor receptor alpha promoter-directed expression of cre recombinase in mouse placenta.

Dev Dyn 2019 Mar 7. Epub 2019 Mar 7.

Department of Pediatrics, University of California San Diego, La Jolla, California.

Background: Numerous pathologies of pregnancy originate from placental dysfunction. It is essential to understand the functions of key genes in the placenta in order to discern the etiology of placental pathologies. A paucity of animal models that allow conditional and inducible expression of a target gene in the placenta is a major limitation for studying placental development and function. Read More

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http://doi.wiley.com/10.1002/dvdy.21
Publisher Site
http://dx.doi.org/10.1002/dvdy.21DOI Listing
March 2019
9 Reads

Mitochondrial Disease (MELAS Syndrome) Discovered at the Start of Pregnancy in a Patient with Advanced CKD: A Clinical and Ethical Challenge.

J Clin Med 2019 Mar 4;8(3). Epub 2019 Mar 4.

Department of Clinical and Biological Sciences, University of Torino, 10100 Torino, Italy.

Pregnancy is a challenge in the life of a woman with chronic kidney disease (CKD), but also represents an occasion for physicians to make or reconsider diagnosis of kidney disease. Counselling is particularly challenging in cases in which a genetic disease with a heterogeneous and unpredictable phenotype is discovered in pregnancy. The case reported regards a young woman with Stage-4 CKD, in which "Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like episodes" (MELAS syndrome), was diagnosed during an unplanned pregnancy. Read More

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http://dx.doi.org/10.3390/jcm8030303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462991PMC
March 2019
1 Read

Congenital papillomavirus infection in cattle: Evidence for transplacental transmission.

Vet Microbiol 2019 Mar 25;230:95-100. Epub 2019 Jan 25.

Dipartimento di Biologia, Università di Napoli Federico II, Napoli, Italy.

Vertical transmission of bovine papillomavirus (BPV) infection was investigated on livers and kidneys of four foetuses from cows suffering from BPV-2-associated urothelial cancers of the urinary bladder. PCR analysis revealed the presence of BPV-2 E5 DNA in the livers and kidneys of two foetuses. Amplified DNA fragments, composed of 502 bp, showed a 100% homology with BPV-2 sequences (GenBank accession number: M20219. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781135183134
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http://dx.doi.org/10.1016/j.vetmic.2019.01.019DOI Listing
March 2019
6 Reads

Renal natural killer cell activation and mitochondrial oxidative stress; new mechanisms in AT1-AA mediated hypertensive pregnancy.

Pregnancy Hypertens 2019 Jan 30;15:72-77. Epub 2018 Nov 30.

Depart. of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, MS, United States; Depart. of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS, United States. Electronic address:

Women with preeclampsia (PE) have increased mean arterial pressure (MAP), natural killer (NK) cells, reactive oxygen species (ROS), and agonistic autoantibodies to the angiotensin II type 1 receptor (AT1-AA). AT1-AA's administered to pregnant rodents produces a well-accepted model of PE. However, the role of NK cells and mitochondrial reactive oxygen species (mtROS) in AT1-AA mediated hypertension during pregnancy is unknown. Read More

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http://dx.doi.org/10.1016/j.preghy.2018.11.004DOI Listing
January 2019
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Placental CD4 T cells isolated from preeclamptic women cause preeclampsia-like symptoms in pregnant nude-athymic rats.

Pregnancy Hypertens 2019 Jan 2;15:7-11. Epub 2018 Nov 2.

University of Mississippi Medical Center, Department of Pharmacology and Toxicology, Jackson, MS, United States; Obstetrics and Gynecology, Jackson, MS, United States. Electronic address:

Preeclampsia (PE), new onset hypertension during pregnancy, is associated with a proinflammatory profile compared to normal pregnancy (NP). We hypothesize that CD4 T cells from PE patient placentas cause PE symptoms during pregnancy compared to those from NP women. CD4 T cells were isolated from placentas of PE and NP women using anti-CD4 magnetic separation, cultured in TexMACS medium at 37 °C in 5% CO, and injected intraperitoneally into nude-athymic rats on day 12 of gestation. Read More

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http://dx.doi.org/10.1016/j.preghy.2018.10.007DOI Listing
January 2019
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Pregnancy in renal transplant patients: Renal function markers and maternal-fetal outcomes.

Pregnancy Hypertens 2019 Jan 31;15:108-113. Epub 2018 Dec 31.

Medical School, The Federal University of Sao Paulo, Obstetrics Department, Brazil. Electronic address:

Objectives: We aimed to evaluate laboratory markers in women who got pregnant after renal transplantation.

Study Design: Cross-sectional prospective study.

Main Outcome Measures: Renal function parameters and maternal and fetal data were assessed in renal transplant recipients. Read More

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http://dx.doi.org/10.1016/j.preghy.2018.12.008DOI Listing
January 2019
2 Reads

Circulating markers of nitric oxide homeostasis and cardiometabolic diseases: insights from population-based studies.

Free Radic Res 2019 Apr 23:1-18. Epub 2019 Apr 23.

c Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Emerging data suggest that impaired nitric oxide (NO) homeostasis has a key role in development of cardiometabolic disorders. The association between circulating levels of NO metabolites, i.e. Read More

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http://dx.doi.org/10.1080/10715762.2019.1587168DOI Listing
April 2019
4 Reads

Deletion of Pregnancy Zone Protein and Murinoglobulin-1 Restricts the Pathogenesis of West Nile Virus Infection in Mice.

Front Microbiol 2019 13;10:259. Epub 2019 Feb 13.

Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, GA, United States.

West Nile virus (WNV) is an enveloped positive-stranded RNA virus that causes meningitis, encephalitis, and acute flaccid paralysis in humans. There are no therapeutic agents available for use against WNV infection. Alpha-2 macroglobulin (A2M) is a major plasma proteinase inhibitor that also has important role in immune modulation. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381297PMC
February 2019
2 Reads

Risk Factors and Outcome of Acute Kidney Injury after Isolated CABG Surgery: a Prospective Cohort Study.

Braz J Cardiovasc Surg 2019 Jan-Feb;34(1):70-75

Department of Anesthesiology and Critical Care, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Acute kidney injury (AKI) is a frequent event after cardiac surgery with increased mortality and morbidity. We explored frequency, risk factors, and associated morbidity and mortality of AKI after isolated coronary artery bypass grafting (CABG) surgery at a single institution.

Methods: All consecutive adults undergoing CABG surgery from March 2013 to October 2016 were assessed for development and severity of AKI based on Acute Kidney Injury Network (AKIN) criteria. Read More

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http://dx.doi.org/10.21470/1678-9741-2017-0209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385837PMC
March 2019
3 Reads

Renal Outcomes of Pregnant Patients with Immunoglobulin A Nephropathy: A Systematic Review and Meta-Analysis.

Am J Nephrol 2019 26;49(3):214-224. Epub 2019 Feb 26.

Department of Nephropathy, Huashan Hospital, Fudan University, Shanghai, China,

Background: Is the prognosis of immunoglobulin A nephropathy (IgAN) influenced by pregnancy and delivery? The answer to this question still remains to be a controversial topic. Here, we undertook a systematic review and meta-analysis to obtain the overall estimate of potential effect of IgAN and pregnancy on each other.

Methods: We systematically searched MEDLINE, EMBASE, Chinese Biological Medicine and Cochrane for cohort and case-control studies; a total of 1,378 articles were reviewed and 9 studies were included in the end. Read More

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http://dx.doi.org/10.1159/000496410DOI Listing
February 2019
4 Reads

Epidemiology of acute kidney injury in hospitalized pregnant women in China.

BMC Nephrol 2019 Feb 26;20(1):67. Epub 2019 Feb 26.

The National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Renal Division, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Ave, Guangzhou, 510515, China.

Background: Epidemiologic data of acute kidney injury (AKI) during pregnancy is lacking in China. This study aims to determine the effect of pregnancy on the risk of AKI among hospitalized women of childbearing age, and to describe the incidence, risk factors and outcomes of AKI in hospitalized pregnant women in China.

Methods: We previously conducted a nationwide, multi-centered cohort of hospitalized patients from 25 hospitals in China during 1/1/2013 to 31/12/2015. Read More

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http://dx.doi.org/10.1186/s12882-019-1255-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390352PMC
February 2019

Post-partum acute kidney injury: sorting placental and non-placental thrombotic microangiopathies using the trajectory of biomarkers.

Nephrol Dial Transplant 2019 Feb 25. Epub 2019 Feb 25.

Sorbonne Université, Urgences Néphrologiques et Transplantation Rénale, Assistance Publique-Hôpital de Paris (APHP), Hôpital Tenon, Paris, France.

Background: Among the severe complications of preeclampsia (PE), acute kidney injury (AKI) is problematic if features of thrombotic microangiopathy (TMA) are present. Although a haemolysis enzyme liver low-platelets syndrome is considerably more frequent, it is vital to rule out a flare of atypical haemolytic and uraemic syndrome (aHUS). Our objective was to improve differential diagnosis procedures in post-partum AKI. Read More

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http://dx.doi.org/10.1093/ndt/gfz025DOI Listing
February 2019
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Non-steroidal anti-inflammatory drugs among chronic kidney disease patients: an epidemiological study.

J Egypt Public Health Assoc 2019 30;94(1). Epub 2019 Jan 30.

1Department of Epidemiology, High Institute of Public Health, Alexandria University, 165 ElHorreya Avenue, ElHadara, Alexandria, Egypt.

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided among chronic kidney disease (CKD) patients. Till now, limited data are available on NSAID use in Egypt, and we aimed to study the prevalence and pattern of NSAID use among CKD patients.

Methods: A cross-sectional study was done among 350 CKD adult patients presented to the Main Alexandria University Hospital. Read More

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http://dx.doi.org/10.1186/s42506-018-0005-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353805PMC
March 2019
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Not only disease activity but also chronic hypertension and overweight are determinants of pregnancy outcomes in patients with systemic lupus erythematosus.

Lupus 2019 Apr 24;28(4):529-537. Epub 2019 Feb 24.

1 Department of Nephrology, Hypertension and Dialysis, Hospices Civils de Lyon, Lyon, France.

Introduction: Pregnancies in women with lupus nephritis are at high-risk of complications, while scarcity of scientific knowledge on prognostic factors impedes a fair medical counseling. We aimed to identify determinants associated with maternal and fetal complications.

Materials: We retrospectively reviewed medical charts of pregnancies that lasted more than 22 weeks in 66 patients with pre-existing lupus nephritis between 2004 and 2013 in France. Read More

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http://dx.doi.org/10.1177/0961203319832097DOI Listing
April 2019
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Pre-eclampsia: pathogenesis, novel diagnostics and therapies.

Nat Rev Nephrol 2019 May;15(5):275-289

Departments of Medicine and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Pre-eclampsia is a complication of pregnancy that is associated with substantial maternal and fetal morbidity and mortality. The disease presents with new-onset hypertension and often proteinuria in the mother, which can progress to multi-organ dysfunction, including hepatic, renal and cerebral disease, if the fetus and placenta are not delivered. Maternal endothelial dysfunction due to circulating factors of fetal origin from the placenta is a hallmark of pre-eclampsia. Read More

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http://dx.doi.org/10.1038/s41581-019-0119-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472952PMC

A Study on Balanced Chromosomal Translocations in Couples with Recurrent Pregnancy Loss.

J Hum Reprod Sci 2018 Oct-Dec;11(4):337-342

Department of Obstetrics and Gynecology, Dr. HL Trivedi Institute of Kidney Diseases and Research Center and Institute of Transplantation Sciences, Ahmedabad, Gujarat, India.

Background: Recurrent pregnancy loss (RPL) is an obstetric complication that affects couples in their reproductive age. Chromosomal abnormalities, mainly balanced rearrangements, could commonly be present in couples with RPL.

Aim: The purpose of this study is to evaluate the contribution of chromosomal abnormalities and balanced reciprocal translocations, in particular occurring in either of the partners, resulting in RPL. Read More

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http://dx.doi.org/10.4103/jhrs.JHRS_132_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333030PMC
February 2019
1 Read