19,486 results match your criteria Renal Disease and Pregnancy

Gestational trophoblastic neoplasm in a patient with end-stage renal failure (ESRF): the challenges and lessons learnt.

BMJ Case Rep 2022 May 18;15(5). Epub 2022 May 18.

Obstetric and Gynaecology, Sarawak General Hospital, Kuching, Sarawak, Malaysia.

Gestational trophoblastic neoplasm (GTN) in end-stage renal failure (ESRF) has not been reported. We reported an unprecedented case of GTN in ESRF from an antecedent partial mole. She had total abdominal hysterectomy and bilateral salpingectomy following the diagnosis as the disease was confined to the uterus. Read More

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Utility of preclinical models of altered maternal nutrition to support the developmental origins of health and disease hypothesis.

Clin Sci (Lond) 2022 May;136(10):711-714

Liggins Institute, University of Auckland, Auckland, New Zealand.

A clear link has been established between alterations in the early life environment and the risk for developing a range of cardiometabolic diseases in later life, a process preferentially termed developmental programming. In particular, alterations in the maternal nutritional environment have been associated with a range of adverse health outcomes in offspring across the lifecourse; effects that can be passed on to future generations. Following from the early epidemiological observations that provided the basis for the developmental origins of health and disease (DOHaD) hypothesis, a range of animal models were developed to examine the impact of early life programming and provide empirical data to support the emerging framework. Read More

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Kidney morphology in pregnancy using T2-weighted MRI.

Clin Radiol 2022 May 12. Epub 2022 May 12.

Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, UK; Departments of Renal Medicine and Women's Health, Barts Health NHS Trust, London, UK. Electronic address:

Aim: To report the morphology of maternal kidneys captured on fetal magnetic resonance imaging (MRI) including kidney length, volume, renal pelvis diameter, and corticomedullary differentiation in pregnancy.

Materials And Methods: A retrospective study of maternal kidney morphology captured incidentally on fetal MRI. Women without chronic kidney disease, with a complete view of both kidneys and a singleton pregnancy were included. Read More

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Pregnancy outcomes in Takayasu arteritis patients.

Semin Arthritis Rheum 2022 Apr 28;55:152016. Epub 2022 Apr 28.

Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. Electronic address:

Objectives: To investigate the pregnancy outcomes of patients with Takayasu arteritis (TAK) and identify the relevant risk factors.

Methods: A total of 110 pregnancies in 80 patients in a Chinese TAK cohort and 550 matched pregnancies in healthy women between 2000 and 2020 were included. The pregnancy outcomes between patients and controls were compared by Fisher's exact test. Read More

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Pregnancy and Kidney Diseases: Multidisciplinary Follow-Up and the Vicious Circles Involving Pregnancy and CKD, Preeclampsia, Preterm Delivery and the Kidneys.

J Clin Med 2022 Apr 30;11(9). Epub 2022 Apr 30.

Nephrology, Azienda Ospedaliera Brotzu, 09047 Cagliari, Italy.

Thomas Addis, the father of nephrology, once wrote that a clinician is complex, "he is part craftsman, part practical scientist, and part historian" [... Read More

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Extracellular Vesicles as an Index for Endothelial Injury and Cardiac Dysfunction in a Rodent Model of GDM.

Int J Mol Sci 2022 Apr 29;23(9). Epub 2022 Apr 29.

Diabetes Research Envisioned and Accomplished in Manitoba (DREAM), Research Theme of the Children's Hospital Research Institute of Manitoba, 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada.

Gestational diabetes mellitus (GDM) increases risk of adverse pregnancy outcomes and maternal cardiovascular complications. It is widely believed that maternal endothelial dysfunction is a critical determinant of these risks, however, connections to maternal cardiac dysfunction and mechanisms of pathogenesis are unclear. Circulating extracellular vesicles (EVs) are emerging biomarkers that may provide insights into the pathogenesis of GDM. Read More

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COVID-19 Infection During Pregnancy Induces Differential Gene Expression in Human Cord Blood Cells From Term Neonates.

Front Pediatr 2022 25;10:834771. Epub 2022 Apr 25.

Neonatology, Thomas Jefferson University/Nemours, Philadelphia, PA, United States.

Background: The COVID-19 pandemic continues worldwide with fluctuating case numbers in the United States. This pandemic has affected every segment of the population with more recent hospitalizations in the pediatric population. Vertical transmission of COVID-19 is uncommon, but reports show that there are thrombotic, vascular, and inflammatory changes in the placenta to which neonates are prenatally exposed. Read More

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Feto-maternal and renal outcomes of nephrotic syndrome in pregnancy.

Saudi J Kidney Dis Transpl 2021 Sep-Oct;32(5):1397-1406

Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Proteinuria can range from subnephrotic to nephrotic amounts during pregnancy, though nephrotic syndrome (NS) is rare (0.012%-0.025%). Read More

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History of Adverse Pregnancy on Subsequent Maternal-Fetal Outcomes in Patients with Immunoglobulin A Nephropathy: A Retrospective Cohort Study from a Chinese Single Center.

Kidney Dis (Basel) 2022 Mar 9;8(2):160-167. Epub 2021 Dec 9.

Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Background: Gestation complications have a recurrence risk and could predispose to each other in the next pregnancy. We aimed to evaluate the relationship between a history of adverse pregnancy and maternal-fetal outcomes in subsequent pregnancy in patients with Immunoglobulin A nephropathy (IgAN).

Methods: A retrospective cohort study from a Chinese single center was conducted. Read More

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Pre-eclampsia with paradoxical polyuria: diabetes insipidus in pregnancy.

Lancet 2022 05;399(10337):1809

Department of Medicine, Division of Endocrinology, National University Hospital, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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Regional variations in nephrology trainee confidence with clinical skills may relate to the availability of local training opportunities in the UK: results from a national survey.

Clin Exp Nephrol 2022 May 7. Epub 2022 May 7.

Department of Renal Transplantation and Nephrology, University Hospitals of Coventry and Warwickshire, Coventry, UK.

Background: The United Kingdom offers a standardised training program for nephrology fellows. However, local training opportunities vary resulting in mismatches between trainee interests and accessible opportunities. This may impact trainee confidence, satisfaction, and future service provision. Read More

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Single-cell atlas of peripheral blood mononuclear cells from pregnant women.

Clin Transl Med 2022 May;12(5):e821

Department of Obstetrics and Gynecology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.

Background: During pregnancy, mother-child interactions trigger a variety of subtle changes in the maternal body, which may be reflected in the status of peripheral blood mononuclear cells (PBMCs). Although these cells are easy to access and monitor, a PBMC atlas for pregnant women has not yet been constructed.

Methods: We applied single-cell RNA sequencing (scRNA-seq) to profile 198,356 PBMCs derived from 136 pregnant women (gestation weeks 6 to 40) and a control cohort. Read More

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Elevated Beta-Human Chorionic Gonadotropin in a Non-pregnant Female With Altered Kidney Function.

Cureus 2022 Apr 1;14(4):e23747. Epub 2022 Apr 1.

Internal Medicine, University at Buffalo, Buffalo, USA.

Elevated beta-human chorionic gonadotropin (beta-hCG) levels in postmenopausal women is a finding known in the literature; however, it still commonly leads to unnecessary and extensive diagnostic workup. We present the case of a 48-year-old African-American postmenopausal female with acute kidney injury on chronic kidney disease (CKD) stage 5 and an incidental finding of elevated serum beta-hCG. Abdominal and transvaginal ultrasound showed no evidence of intrauterine or ectopic pregnancy or gestational trophoblastic disease. Read More

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The Impact of Preeclampsia in Lupus Nephritis.

Expert Rev Clin Immunol 2022 May 10:1-13. Epub 2022 May 10.

Independent Researcher, Past Director Nephrology Policlinico, Milan, Italy.

Introduction: Women with systemic lupus erythematosus (SLE), particularly those with lupus nephritis (LN), remain at high risk for adverse pregnancy outcome. Although in the last decades maternal and fetal outcomes have improved dramatically, preeclampsia remains a major cause of maternal and perinatal morbidity and mortality.

Areas Covered: A narrative review of literature was conducted, underlying the importance of pre-conception counseling, and focusing on the correlation between preeclampsia and LN. Read More

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Pregnancy in a woman undergoing peritoneal dialysis: Management and dialysis options.

Clin Nephrol Case Stud 2022 29;10:32-36. Epub 2022 Apr 29.

Nephrology Department, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.

Pregnancy in patients with end-stage renal disease on maintenance dialysis is uncommon, with annual incidences reported at 0.3 - 2.7%. Read More

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[Factors associated with the survival of fetuses with a prenatal diagnosis of megabladder].

Andes Pediatr 2022 Feb 28;93(1):78-85. Epub 2022 Mar 28.

Facultad de Medicina, Universidad de Chile, Santiago, Chile.

The presence of fetal megacystis in a renal ultrasound may suggest a mechanical or functional bladder outlet obstruction, an uncommon condition with a poor outcome.

Objective: To determine prog nostic factors in fetuses with prenatal diagnosis of megacystis.

Patients And Method: Retrospective study carried out between 2003 and 2018 in the Orient Perinatal Reference Center (CERPO), Uni versity of Chile. Read More

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February 2022

Hepatic Infarction in a Patient With Sickle Cell Trait Presenting With HELLP Syndrome.

Cureus 2022 Apr 1;14(4):e23724. Epub 2022 Apr 1.

Internal Medicine, Manipal College of Medical Sciences, Pokhara, NPL.

Hepatic infarction is uncommon due to the dual blood supply from the hepatic artery and portal vein. The majority of the cases are caused following liver transplant or hepatobiliary surgery, hepatic artery occlusion, or shock. Hepatic infarction is a rare complication of hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome. Read More

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Health Outcome of 215 Mothers of Children with Autoimmune Congenital Heart Block: Analysis of the French Neonatal Lupus Syndrome Registry.

J Rheumatol 2022 May 2. Epub 2022 May 2.

Cochin Hospital, Ile de France Rare Autoimmune and Systemic Diseases Reference Center, Paris, France; Reference Center for Complex Congénital Cardiac Malformations - M3C, Necker-Enfants Malades Hospital, Université from Paris, Paris, France; Obstetrics and maternal-fetal unit / APHP Hôpital Necker-Enfant Malades, Université from Paris, Paris, France; Department of Internal Medicine, CHU Nantes, France; Rare Autoimmune and Systemic Diseases Competence Center, Reims, France; Pitié-Salpêtrière Hospital, Reference Center for Rare Autoimmune and Systemic Diseases, Paris, France; Timone Children's Hospital, Unité of Pediatric Resuscitation, Marseille, France; Tenon Hospital, Paris, France; CHU Fort de France, Martinique, France; Univ. Lille, Inserm, CHU Lille, Department of Internal Medicine and Clinical Immunology, Reference Center for Rare Systemic Autoimmune Diseases in the North and North-West of France (CeRAINO) , U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000 Lille, France; Cardiopédiatrics, University Hospital of Nantes, France; Cochin Hospital, Ile de France Rare Autoimmune and Systemic Diseases Reference Center, Paris, France; University Paris Descartes- Sorbonne Paris Cité, Paris, France; INSERM U 1153, Center for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France. Address for correspondence: Nathalie Costedoat-Chalumeau, Hôpital Cochin, 75014, Paris, France. Fax number: +33158413246. Phone number: +33687508123

Objective: Transplacental passage of maternal anti-SSA and -SSB antibodies, potentially associated with maternal autoimmune diseases, can cause neonatal lupus syndrome. Given the paucity of data in this setting, we report short- and long-term outcomes of mothers of offspring with congenital heart block (CHB).

Methods: This retrospective study included anti-SSA/SSB antibody-positive mothers of fetuses with high-degree CHB and focused on their health status before pregnancy, at CHB diagnosis, and thereafter. Read More

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Development and validation of a clinical diagnostic model for pregnant women with renal colic in the emergency department in China: a protocol for a retrospective cohort study.

BMJ Open 2022 May 2;12(5):e056510. Epub 2022 May 2.

Department of Clinical Laboratory, Ruian People's Hospital, Ruian, China.

Introduction: Urolithiasis affects many people throughout their lives. Among the maternal population, although the morbidity of acute urolithiasis in pregnant women is unremarkable, it is the leading cause of hospitalisation during pregnancy. There is no effective clinical diagnostic tool to help doctors diagnose diseases. Read More

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Treatment Challenges in Multiple Sclerosis - A Continued Role for Glatiramer Acetate?

Front Neurol 2022 15;13:844873. Epub 2022 Apr 15.

Lycalis sprl, Brussels, Belgium.

Earlier diagnosis, access to disease-modifying therapies (DMTs), and improved supportive care have favorably altered the disease course of multiple sclerosis (MS), leading to an improvement in long-term outcomes for people with MS (PwMS). This success has changed the medical characteristics of the population seen in MS clinics. Comorbidities and the accompanying polypharmacy, immune senescence, and the growing number of approved DMTs make selecting the optimal agent for an individual patient more challenging. Read More

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Test for Measuring Complement Attack on Endothelial Cells: From Research to Bedside.

Front Immunol 2022 12;13:860689. Epub 2022 Apr 12.

Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.

As part of the innate immune system, the complement system plays a key role in defense against pathogens and in host cell homeostasis. This enzymatic cascade is rapidly triggered in the presence of activating surfaces. Physiologically, it is tightly regulated on host cells to avoid uncontrolled activation and self-damage. Read More

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Prevalence of long term metabolic, cardiovascular, cerebrovascular and renal disease in patients with hypertensive disorders in pregnancy remote from pregnancy (POMCH).

Pregnancy Hypertens 2022 Apr 27;28:162-167. Epub 2022 Apr 27.

Southwest Sydney Local Health District, NSW, Australia; Women's Health Initiative Translational Unit, Ingham Institute, Campbell St, Liverpool, NSW, Australia; School of Medicine Western Sydney University, Locked Bag 1797, Penrith, NSW, Australia; Clinical School, South Western Sydney, University New South Wales, Liverpool Hospital, Liverpool, Australia. Electronic address:

Background: Hypertensive disorders of pregnancy (HDP) are associated with an increased risk of long-term cardiovascular, cerebrovascular, and adverse renal outcomes. Biomarkers including soluble fms-like tyrosine kinase 1 (sFlt1), placental growth factor (PlGF) are predictive of the development of preeclampsia. Their long-term value in predicting which women will develop cardiovascular complications remote from pregnancy is not yet established. Read More

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A woman with Alport syndrome in compound-heterozygous state in pregnancy: lessons for the clinical nephrologist.

J Nephrol 2022 Apr 30. Epub 2022 Apr 30.

Renal Division, Peking University First Hospital, Kidney Genetic Center, Peking University Institute of Nephrology, No. 8 Xi Shi Ku Street, Xi Cheng District, Beijing, 100034, People's Republic of China.

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[Modern algorithm of diagnosis and treatment of acute gestational pyelonephritis in a large industrial city].

Urologiia 2022 May(2):34-42

Perm State Medical University named after E.A. Wagner Academy of Health of the Russian Federation, Perm, Russia.

The Purpose Of The Study: to develop a modern algorithm for the diagnosis and treatment of acute gestational pyelonephritis in a large industrial city and to study the possibilities of phytotherapy as an integral part of this algorithm.

Materials And Methods: The study consisted of two stages and included 629 patients treated over 12 years (2010-2021) in Perm city with a population of 1.1 million people. Read More

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Maternal high-fat diet consumption during pregnancy and lactation predisposes offspring to renal and metabolic injury later in life: comparative study of diets with different lipid contents.

J Dev Orig Health Dis 2022 Apr 28:1-9. Epub 2022 Apr 28.

Department of Physiology, Federal University of Uberlândia, Uberlândia, Brazil.

Accumulating evidence suggests that maternal overnutrition can result in a higher development risk of obesity and renal disease in the offspring's adulthood. The present study tested different lipid levels in the maternal diet during pregnancy and lactation and its repercussions on the offspring of Wistar rats. Offspring of 1, 7, 30 and 90-d-old were divided into the following groups: Control (CNT) - offspring of dams that consumed a standard chow diet (3. Read More

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Mitochondrial pharmacotherapy during pregnancy and lactation in an ADPKD mouse model: a win for both mothers and their offspring.

Kidney Int 2022 05;101(5):870-872

Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, USA; The Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, USA. Electronic address:

Pharmacotherapies that are safe during pregnancy are lacking for patients with autosomal dominant polycystic kidney disease. In this issue, Daneshgar et al. reveal that administration of the mitochondrial-protective peptide, elamipretide, during pregnancy and lactation in a mouse model with autosomal dominant polycystic kidney disease, is nonteratogenic and attenuates disease severity in both mothers and their affected offspring. Read More

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Associations among prenatal PM, birth weight, and renal function.

Chemosphere 2022 Apr 20;301:134668. Epub 2022 Apr 20.

Division of Nutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Massachusetts Boston, USA.

Background: Low birth weight has long-term health effects, including neurodevelopmental delays, cardiovascular diseases, and type 2 diabetes, through epigenetic changes and modifications. Numerous studies have identified that PM is associated with low birth weight. However, the association between PM and renal function, as well as the mediated effect of renal function on the association between prenatal PM and birth weight are still under-recognized. Read More

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Longitudinal gut virome analysis identifies specific viral signatures that precede necrotizing enterocolitis onset in preterm infants.

Nat Microbiol 2022 May 21;7(5):653-662. Epub 2022 Apr 21.

School of Life Sciences, Arizona State University, Tempe, AZ, USA.

Necrotizing enterocolitis (NEC) is a serious consequence of preterm birth and is often associated with gut bacterial microbiome alterations. However, little is known about the development of the gut virome in preterm infants, or its role in NEC. Here, using metagenomic sequencing, we characterized the DNA gut virome of 9 preterm infants who developed NEC and 14 gestational age-matched preterm infants who did not. Read More

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A presentation of adenovirus with hypokalemia and rhabdomyolysis in pregnancy.

Obstet Med 2022 Mar 7;15(1):59-61. Epub 2020 Dec 7.

Brown University Warren Alpert Medical School, Providence, RI, USA.

Background: Adenovirus infection is usually mild in presentation. However during pregnancy, the course can be more severe.

Case: A 21-year-old woman in her second pregnancy presented with abdominal pain, vomiting, and fevers at 34 weeks and 4 days of gestation. Read More

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