657,179 results match your criteria Renal & Urology News [Journal]


Spinal cord watershed infarction: Novel findings on magnetic resonance imaging.

Clin Imaging 2019 Jan 31;55:71-75. Epub 2019 Jan 31.

Department of Radiology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32611, USA. Electronic address:

Spinal cord watershed ischemia is a rare phenomenon often associated with cardiac arrest, prolonged hypotension, and atherosclerotic disease. It can manifest as central necrosis with peripheral sparing in the transverse axis, and central lesion with rostral and caudal sparing in the longitudinal axis. Few reports provide detailed imaging findings of spinal cord watershed ischemia lesions. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.01.023DOI Listing
January 2019

Type B Aortic Dissection post NELLIX endovascular aneurysm sealing (EVAS).

Ann Vasc Surg 2019 Feb 11. Epub 2019 Feb 11.

Department of Vascular Surgery, Singapore General Hospital; Vascular Service, Sengkang General Hospital.

Objectives: Endovascular aneurysm sealing (EVAS) was developed with the intention of expanding the anatomical limitations of conventional endovascular repair (EVAR) devices, as well as decrease rates of re-intervention secondary to migration and type II endoleaks in treatment of abdominal aortic aneurysms (AAA). Since its inception, EVAS has gained much popularity especially for patients with concomitant common iliac aneurysms, with good long term durability suggested by several studies. Currently, the known complications of EVAS, whilst considered uncommon, include endoleaks, renal artery and limb thrombosis. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.11.014DOI Listing
February 2019

Kidney Preservation Using Renal Heterotopic Autotransplantation During F-Evar For Complex Residual Type-A Aortic Dissection.

Ann Vasc Surg 2019 Feb 11. Epub 2019 Feb 11.

Vascular and Endovascular Surgery Unit, Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy.

The treatment of type A acute aortic dissection is a challenge for the surgeon, and serious late-complications may occur even after surgical repair. We report treatment following a type A post-dissection thoraco-abdominal aneurysm in a patient who previously underwent ascending aortic reconstruction using a biological aortic valve and Dacron prosthetic graft implantation in emergency conditions. The multi-staged approach consisted in removing the right kidney and performing a heterotopic autotransplantation in the left iliac fossa before positioning a fenestrated endograft (celiac trunk, superior mesenteric artery and left renal artery). Read More

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http://dx.doi.org/10.1016/j.avsg.2018.11.008DOI Listing
February 2019

Filter-associated inferior vena cava thrombosis with duodenal perforation: case report and literature review.

Ann Vasc Surg 2019 Feb 11. Epub 2019 Feb 11.

Department of Thoracic and Vascular Surgery, Arnaud de Villeneuve Hospital, Montpellier, France.

Objectif: The aim of this paper is to report a case of filter associated inferior vena cava (IVC) thrombosis with perforation of the duodenum and penetration of a vertebral body by the filter struts.

Case Report: A 37 year old woman with a medical history of Behcet`s disease treated with corticosteroids, underwent placement of a retrievable IVC filter because of recurrent ileofemoral venous thrombosis regardless of therapeutic levels of anticoagulation. Despite a correct positioning of the filter, the second follow-up CT-scan, performed at 1 year, showed a complete thrombosis of the infra-renal IVC segment, with perforation of the vessel wall by the filter struts and penetration in the duodenum. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.11.021DOI Listing
February 2019

Association betweenPNPLA3rs738409, polymorphism, decreased kidney function in postmenopausal type 2, diabetic women with or without non-alcoholic fatty liver disease.

Diabetes Metab 2019 Feb 11. Epub 2019 Feb 11.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University Hospital of Verona, Verona, Italy. Electronic address:

Aim: - Evidence is emerging that PNPLA3 rs738409 polymorphism (the major genetic variant associated with susceptibility to non-alcoholic fatty liver disease [NAFLD]) is associated with chronic kidney disease (CKD) in non-diabetic individuals. Currently, little is known about this association in type 2 diabetic (T2DM) patients with and without NAFLD.

Methods: - We studied 101 Caucasian post-menopausal women with T2DM, consecutively attending our diabetes outpatient service during a 3-month period. Read More

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http://dx.doi.org/10.1016/j.diabet.2019.01.011DOI Listing
February 2019

Erianin protects against high glucose-induced oxidative injury in renal tubular epithelial cells.

Food Chem Toxicol 2019 Feb 11. Epub 2019 Feb 11.

Department of Pharmacy and Master Program, Collage of Pharmacy and Health Care, Tajen University, Pingtung County, 90741, Taiwan. Electronic address:

Erianin is the major bibenzyl compound found in Dendrobium chrysotoxum Lindl. The current study was designed to investigate the protective effects of erianin on high glucose-induced injury in cultured renal tubular epithelial cells (NRK-52E cells) and determine the possible mechanisms for its effects. NRK-52E cells were pretreated with erianin (5, 10, 25 or 50 nmol/L) for 1 h followed by further exposure to high glucose (30 mmol/L, HG) for 48 h. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.021DOI Listing
February 2019

Lysophosphatidic acid receptor 1 inhibitor, AM095, attenuates diabetic nephropathy in mice by downregulation of TLR4/NF-κB signaling and NADPH oxidase.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 11. Epub 2019 Feb 11.

College of Pharmacy, Gachon University, Incheon, Republic of Korea; Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea; Gachon University Gil Medical Center, Gachon Medical and Convergence Institute, Incheon, Republic of Korea. Electronic address:

Diabetic nephropathy (DN) is one of the major long-term complications of diabetes. Lysophosphatidic acid (LPA) signaling has been implicated in renal fibrosis. In our previous study, we found that the LPA receptor 1/3 (LPAR1/3) antagonist, ki16425, protected against DN in diabetic db/db mice. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.001DOI Listing
February 2019

Postmortem evidence of disseminated Zika virus infection in an adult patient.

Int J Infect Dis 2019 Feb 11. Epub 2019 Feb 11.

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Institute of Infectious Disease and Epidemiology, Tan Tock Seng Hospital, Singapore.

Zika virus infections in immunocompetent adults typically are asymptomatic or cause mild symptoms, but have also been associated with neurological complications including Guillain-Barre Syndrome. Zika virusassociated non-neurological fatalities in adults are rare. Herein, we describe a decedent with multiple commodities who developed an acute febrile illness with rash days prior to death. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.047DOI Listing
February 2019

[Modern approaches to dietary support for patients with diabetic nephropathy].

Vopr Pitan 2018 13;87(6):6-15. Epub 2018 Nov 13.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

The article presents modern approaches to dietary support of patients with diabetic nephropathy (DN) characterized by gradual sclerosis of the renal tissue, leading to a loss of filtration and nitrogen excretory function of the kidneys. An analysis of publications of domestic and foreign authors indicates a slowdown in the progression of chronic kidney disease against the background of low-protein diets. However, the role of protein restriction and its qualitative composition in the diet of patients with DN is the subject of comprehensive discussion. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10061DOI Listing
November 2018

Renal and Vascular Effects of Kallikrein Inhibition in a Model of Lonomia obliqua Venom-Induced Acute Kidney Injury.

PLoS Negl Trop Dis 2019 Feb 14;13(2):e0007197. Epub 2019 Feb 14.

Laboratório de Bioquímica Farmacológica, Centro de Pesquisa Experimental (CPE), Hospital de Clínicas de Porto Alegre (HCPA-UFRGS), Porto Alegre, RS, Brazil.

Background: Lonomia obliqua venom is nephrotoxic and acute kidney injury (AKI) is the main cause of death among envenomed victims. Mechanism underlying L. obliqua-induced AKI involves renal hypoperfusion, inflammation, tubular necrosis and loss of glomerular filtration and tubular reabsorption capacities. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007197DOI Listing
February 2019

Indications for echocardiography of replacement heart valves: a joint statement from the BHVS and BSE.

Echo Res Pract 2019 Feb 1. Epub 2019 Feb 1.

R Steeds, Cardiology, University Hospital of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland.

Echocardiography plays a vital role in the follow up of patients with replacement heart valves. However, there is considerable variation in international guidelines regarding the recommended time points after implantation at which routine echocardiography should be performed. The purpose of routine echocardiography is to detect early structural valve deterioration in biological valves to improve the timing of redo interventions. Read More

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http://dx.doi.org/10.1530/ERP-18-0079DOI Listing
February 2019

Fetal abdominal cysts: antenatal course and postnatal outcomes.

J Perinat Med 2019 Feb 14. Epub 2019 Feb 14.

Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, UK.

Background There is little information on which to base the prognostic counselling as to whether an antenatally diagnosed fetal abdominal cyst will grow or shrink, or need surgery. This study aims to provide contemporary data on prenatally diagnosed fetal abdominal cysts in relation to their course and postnatal outcomes. Methods Fetal abdominal cysts diagnosed over 11 years in a single centre were identified. Read More

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http://dx.doi.org/10.1515/jpm-2018-0311DOI Listing
February 2019

Laparoscopic pyeloplasty practice patterns in Canada.

Can Urol Assoc J 2019 Jan 21. Epub 2019 Jan 21.

Division of Urology, Department of Surgery, The Ottawa Hospital and University of Ottawa, Ottawa, ON, Canada.

Introduction: Ureteropelvic junction obstruction (UPJO) is a condition characterized by partial or complete obstruction of urine transport from the renal pelvis to the ureter and can present with intermittent flank pain, recurrent urinary tract infections, renal stones, or renal dysfunction. While historically, open pyeloplasty was the gold standard for surgical management, laparoscopic methods to repair UPJO have largely taken over as the preferred approach for adolescent and adult patients. Despite near universal adoption of laparoscopic pyeloplasty among Canadian urologists, it remains a technically complex procedure and considerable variability exists in the procedural steps performed. Read More

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http://dx.doi.org/10.5489/cuaj.5675DOI Listing
January 2019

Percutaneous irreversible electroporation for the treatment of small renal masses: The first Canadian case series.

Can Urol Assoc J 2019 Jan 21. Epub 2019 Jan 21.

Department of Surgery, Division of Urology, University of Saskatchewan, Saskatoon, SK, Canada.

Introduction: Irreversible electroporation (IRE) is a novel technology used in the minimally invasive treatment of small solid organ tumours. Currently, there is a paucity of literature studying treatment of small renal masses (SRMs) with IRE. Our pilot study is the first case series in Canada to use IRE in the treatment of SRMs. Read More

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http://dx.doi.org/10.5489/cuaj.5728DOI Listing
January 2019

Detection of circulating tumour cells and their potential use as a biomarker for advanced renal cell carcinoma.

Can Urol Assoc J 2019 Jan 21. Epub 2019 Jan 21.

Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Introduction: The aim of this study was to detect circulating tumour cells (CTCs) in patients with advanced renal cell carcinoma (RCC) using a novel CTC detection platform. Furthermore, we evaluated the clinical outcomes associated with a CTC-positive status.

Methods: A total of 34 patients with advanced RCC (stage III or IV) were prospectively enrolled, and 104 peripheral blood samples were analyzed for the presence of CTCs at various time points. Read More

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http://dx.doi.org/10.5489/cuaj.5605DOI Listing
January 2019
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Recommendations for ultrasonographic assessment of renal arteries.

J Ultrason 2018 ;18(75):338-343

Department of General Surgery and Endocrinology, Medical University of Warsaw , Poland.

The present clinical practice recommendations are addressed to physicians of all specialties, who perform Doppler ultrasound examinations of the kidneys on a daily basis, and in particular to specialists in radiology and imaging diagnostics. The recommendations were based on the Ultrasonography Standards of the Polish Ultrasound Society and current scientific reports consistent with Evidence Based Medicine. The paper discusses patient preparation protocol, examinat ion technique with particular emphasis on patient's position allowing to obtain proper Doppler angle of insonation, as well as diagnostic limitations of the technique. Read More

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http://dx.doi.org/10.15557/JoU.2018.0049DOI Listing
January 2018

What do renal stents and parachutes have in common?

Catheter Cardiovasc Interv 2019 Feb 14. Epub 2019 Feb 14.

Department of Medicine and Cardiology, Ochsner Clinical School, University of Queensland, AU, Ochsner Medical Center, New Orleans, Louisiana.

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http://dx.doi.org/10.1002/ccd.28151DOI Listing
February 2019

Long noncoding RNA MALAT1 mediates high glucose-induced glomerular endothelial cell injury by epigenetically inhibiting klotho via methyltransferase G9a.

IUBMB Life 2019 Feb 14. Epub 2019 Feb 14.

Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Several recent reporters have indicated the potential role of long noncoding RNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in diabetic nephropathy (DN). However, these studies mainly focus on renal tubular epithelial cells HK-2, the role of MALAT1 in human renal glomerular endothelial cells (HRGECs) remains unclear. Hence, this study aimed to explore the role of MALAT1 in high glucose (HG)-induced HRGECs injury and the underlying epigenetic mechanism. Read More

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http://dx.doi.org/10.1002/iub.2009DOI Listing
February 2019

99mTc-LLEC Renal Dynamic Scan in a Patient With Pelvic Neuroblastoma.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

Department of Nuclear Medicine, JIPMER, Puducherry, Pondicherry, India.

A 5-month-old boy with ultrasonography showing bilateral hydronephrosis, referred for renal scan. On Tc-L,L,ethylenedicysteine (Tc-LLEC) renal scan, tracer blush in flow images in the region of urinary bladder was seen and tumor mass was suspected. Contrast-enhanced CT showed a soft tissue mass in sacrococcygeal region. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002491DOI Listing
February 2019

Novel Functional Renal PET Imaging With 18F-FDS in Human Subjects.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

Department of Nuclear Medicine, and.

The novel PET probe 2-deoxy-2-F-fluoro-D-sorbitol (F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in 2 human volunteers. F-FDS was produced by a simple 1-step reduction from F-FDG. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002494DOI Listing
February 2019

Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome-Associated Renal Cell Carcinoma Showing High FDG Uptake.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

Department of Pathology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome is a rare autosomal-dominant disease, characterized by the development of cutaneous and uterine leiomyomas and renal cell carcinoma (RCC). Approximately 20% to 30% of patients with HLRCC syndrome develop RCC resembling sporadic type 2 papillary RCC, which is aggressive and associated with a poor prognosis. Information on the clinical usefulness of FDG PET/CT in HLRCC syndrome-associated RCC is limited. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002495DOI Listing
February 2019

18F-FDG PET/CT Demonstrates Renal Cell Cancer in a Transplant With Synchronous Intestinal Infection.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

From the Departments of Nuclear Medicine and PET/CT, and.

We present a case of a 22-year-old man with history of allogenic renal transplantation on immunosuppression, who underwent F-FDG-PET/CT to characterize a lesion in the transplanted kidney on ultrasonogram and contrast-enhanced computed tomography imaging. PET/CT revealed FDG avid lesion in the transplanted kidney and mural thickening involving the distal ileum, ileocecal junction, and ileocolic lymph nodes. Subsequent histopathological examination from the renal lesion revealed renal cell carcinoma in the transplanted kidney. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002482DOI Listing
February 2019

Dual anti-neutrophil cytoplasmic antibody and anti-glomerular basement membrane antibody-positive crescent glomerulonephritis in a patient with monoclonal gammopathy of undetermined significance: A case report.

Medicine (Baltimore) 2019 Feb;98(7):e14557

Department of Nephrology.

Rationale: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and anti-glomerular basement membrane (GBM) antibody disease are both rare autoimmune diseases. Monoclonal gammopathy of undetermined significance (MGUS) is one of the most common causes of plasma cell dyscrasias (PCD). The three entities can cause renal lesions via different mechanisms and, however, they have not been reported in a single patient with renal lesion. Read More

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http://dx.doi.org/10.1097/MD.0000000000014557DOI Listing
February 2019

Local recurrence of sinonasal renal cell-like adenocarcinoma: A CARE compliant case report.

Medicine (Baltimore) 2019 Feb;98(7):e14533

Department of Pathology.

Rationale: Sinonasal renal cell-like adenocarcinoma (SNRCLA) is a very rare sino-nasal carcinoma. Because SNRCLA has the same morphological features as other clear cell carcinomas, and some of them also occurred in sinonasal part, it is necessary to differentiate SNRCLA from these tumors.

Patient Concerns: A 42-year-old man presented with complaints of epistaxis for 1 day. Read More

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http://dx.doi.org/10.1097/MD.0000000000014533DOI Listing
February 2019

Nephrocalcinosis in adolescent girl with medullary sponge kidney and mild hemihypertrophy: A case report.

Medicine (Baltimore) 2019 Feb;98(7):e14529

Department of Pediatric Nephrology.

Rationale: Medullary sponge kidney (MSK) is a rare congenital abnormality characterized by cystic dilatation of the medullary collecting tubules. The disorder is likely to be complicated by nephrocalcinosis, urolithiasis, tubular dysfunctions, and urinary tract infections. In addition, it may be rarely associated with extrarenal anomalies. Read More

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http://dx.doi.org/10.1097/MD.0000000000014529DOI Listing
February 2019

Risk of subsequent health disorders among living kidney donors.

Medicine (Baltimore) 2019 Feb;98(7):e14494

Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University.

Few studies have investigated the risk of physiological sequelae in living kidney donors (KDs). We conducted a population-based cohort study using the National Health Insurance Research Database of Taiwan, which covers more than 99% of citizens.We comprehensively investigated the risk of medical disorders after kidney donation in living KDs using a maximum follow-up of 13 years. Read More

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http://dx.doi.org/10.1097/MD.0000000000014494DOI Listing
February 2019

The association between human papillomavirus infection and head and neck cancer: A population-based cohort study.

Medicine (Baltimore) 2019 Feb;98(7):e14436

School of Medicine, Chung Shan Medical University.

Human papillomavirus (HPV) has been linked with development of oropharyngeal squamous cell carcinoma, a subset of head and neck cancer (HNC). This study aimed to evaluate the association between HPV infection and subsequent development of HNC and to report epidemiological information in Taiwan.This population-based cohort study retrieved patient data from the longitudinal health insurance database (LHID) of Taiwan's National Health Insurance Research Database (NHIRD) from 2005 to 2010 and analyzed it retrospectively. Read More

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http://dx.doi.org/10.1097/MD.0000000000014436DOI Listing
February 2019

The effects of perioperative intravenous fluid administration strategy on renal outcomes in patients undergoing cardiovascular surgery: An observational study.

Medicine (Baltimore) 2019 Feb;98(7):e14383

Department of Anesthesiology and Pain Medicine.

We assessed whether perioperative fluid management with balanced solutions and a limited volume of hydroxyethyl starch (renal-protective fluid management [RPF] strategy) could improve renal outcomes after cardiovascular surgery.For this retrospective observational study, we evaluated 2613 patients who underwent cardiovascular surgery from January 1, 2010 to December 31, 2013. The control group were given intravenous fluids with saline-based solutions and unlimited volumes of hydroxyethyl starch solutions and the RPF group were given intravenous fluids with RPF. Read More

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http://dx.doi.org/10.1097/MD.0000000000014383DOI Listing
February 2019

Living or deceased donor kidney transplantation in children.

Curr Opin Pediatr 2019 Feb 11. Epub 2019 Feb 11.

Division of Pediatric Nephrology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.

Purpose Of Review: Kidney transplantation is the preferred treatment modality for children with end-stage renal disease. In this review, we discuss the factors affecting the selection of the appropriate donor to ensure the best possible short and long-term outcomes.

Recent Findings: Outcomes of pediatric renal transplantation from living donors are superior to those obtained from deceased donors. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000740DOI Listing
February 2019

Volume Computed Tomography Perfusion Imaging: Evaluation of the Significance in Oncologic Follow-up of Metastasizing Renal Cell Carcinoma in the Early Period of Targeted Therapy - Preliminary Results.

J Comput Assist Tomogr 2019 Feb 11. Epub 2019 Feb 11.

Department of Radiology, and.

Introduction: The aim of this study was to assess the significance of volume computed tomography perfusion imaging of metastasizing renal cell carcinoma (mRCC) in the early period after the initiation of targeted therapy.

Methods: Blood flow (BF), blood volume, and clearance (CL) were calculated in 10 patients with histologically verified mRCC before and 1 month after initiation of targeted therapy using compartmental analysis algorithms. In addition, the longest diameter of tumor was measured for both time points and compared. Read More

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http://dx.doi.org/10.1097/RCT.0000000000000848DOI Listing
February 2019

Influence of renal function by transplant operation for living-related kidney donors in a short term.

Chin Med J (Engl) 2019 Feb 8. Epub 2019 Feb 8.

Department of Urology/Institute of Urology/Organ Transplantation Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

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http://dx.doi.org/10.1097/CM9.0000000000000080DOI Listing
February 2019

Oral nutritional supplements and 30-day readmission rate in hypoalbuminemic maintenance hemodialysis patients.

Hemodial Int 2019 Feb 14. Epub 2019 Feb 14.

Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, USA.

Introduction: Hemodialysis (HD) patients are hospitalized nearly twice yearly, and 35% of these patients are rehospitalized within 30-days postdischarge. We hypothesized that monitored oral nutritional supplementation (ONS) during HD treatment may decrease readmissions.

Methods: A cohort of maintenance HD patients, treated at a large dialysis organization, who were hospitalized with a postdischarge albumin of ≤3. Read More

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http://dx.doi.org/10.1111/hdi.12694DOI Listing
February 2019

Aiming for the optimal bicarbonate prescription for maintenance hemodialysis therapy in end-stage renal disease.

Hemodial Int 2019 Feb 14. Epub 2019 Feb 14.

General Hospital of Thessaloniki "Agios Pavlos", Nephrology Department, Thessaloniki, Greece.

Introduction: Acidemia and alkalemia, as a result of gradual depletion of the body's buffers followed by rapid repletion during hemodialysis (HD), are linked to adverse consequences. We examined the acid-base status with dialysis bath of higher bicarbonate (HC03 ) concentration or standard HC03 bath plus oral HC03 supplementation.

Methods: A total of 60 stable HD patients (pts) were evaluated according to their pre-dialysis acid-base status both before the first and the second session of the week dialyzed against standard base dialysate of 35 mmol/L. Read More

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http://dx.doi.org/10.1111/hdi.12710DOI Listing
February 2019

Uric acid and the cardio-renal effects of SGLT2 inhibitors.

Diabetes Obes Metab 2019 Feb 14. Epub 2019 Feb 14.

School of Life and Health Sciences, Aston University, Birmingham, UK.

Sodium/glucose co-transporter-2 (SGLT2) inhibitors, which lower blood glucose by increasing renal glucose elimination have been shown to reduce the risk of adverse cardiovascular (CV) and renal events in type 2 diabetes. This has been ascribed in part to haemodynamic changes, body weight reduction and several possible effects on myocardial, endothelial and tubulo-glomerular functions as well as reduced glucotoxicity. This review evaluates evidence that an effect of SGLT2 inhibitors to lower uric acid may also contribute to reduced cardio-renal risk. Read More

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http://dx.doi.org/10.1111/dom.13670DOI Listing
February 2019

Experience with antiviral agents for treatment of hepatitis C virus infection in hemodialysis patients on the kidney wait list.

Hemodial Int 2019 Feb 14. Epub 2019 Feb 14.

Department of Transplantation and General Surgery, Baskent University Faculty of Medicine, Adana, Turkey.

Introduction: Hepatitis C virus (HCV) infection is associated with increased mortality and morbidity in kidney transplant patients. The ability to establish a sustained viral response before renal transplant is important for these patients. Direct-acting antiviral agents can increase the sustained viral response in most patients with HCV infection. Read More

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http://dx.doi.org/10.1111/hdi.12719DOI Listing
February 2019

New trends in voiding cystourethrography and vesicoureteral reflux: Who, when and how?

Int J Urol 2019 Feb 14. Epub 2019 Feb 14.

Department of Urology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Vesicoureteral reflux, retrograde flow of urine from the bladder into the upper urinary tract, is one of the most common urological diagnoses in the pediatric population. Diagnosis and subsequent management of urinary reflux have become increasingly debated in the past decade, with divergent opinions over which patients should be evaluated for reflux, and when detected, which children should receive intervention. Although some argue that vesicoureteral reflux is a "phenotype" that often resolves without intervention, others contest that untreated reflux has the potential to cause irreversible renal damage over time. Read More

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http://doi.wiley.com/10.1111/iju.13915
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http://dx.doi.org/10.1111/iju.13915DOI Listing
February 2019
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Renal Artery Denervation for Hypertension.

Curr Treat Options Cardiovasc Med 2019 Feb 14;21(2). Epub 2019 Feb 14.

Duke University Medical Center, 2301 Erwin Rd, Durham, NC, 27710, USA.

Purpose Of Review: Hypertension (HTN) has a growing impact, already affecting over 1 billion people. An estimated 2-16% of those with HTN have resistant HTN. The sympathetic nervous system (SNS) is a recognized contributor to the pathophysiology of resistant HTN. Read More

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http://dx.doi.org/10.1007/s11936-019-0715-6DOI Listing
February 2019

Factors associated with glomerular filtration rate variation in primary hyperparathyroidism after parathyroidectomy

Turk J Med Sci 2019 Feb 11;49(1):295-300. Epub 2019 Feb 11.

Background/aim: Prolonged hypercalcemia impairs renal function, and a reduced glomerular filtration rate (GFR) is typical in advanced primary hyperparathyroidism (PHPT). There are scarce data related to predictors of renal impairment in patients with PHPT. Hence, we aimed to evaluate changes in kidney function in PHPT patients after parathyroidectomy (PTX) and identify factors associated with GFR variation in these patients. Read More

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http://dx.doi.org/10.3906/sag-1806-181DOI Listing
February 2019

Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease

Turk J Med Sci 2019 Feb 11;49(1):327-335. Epub 2019 Feb 11.

Background/aim: Fetuin-A, a circulating inhibitor of calcification, is a marker of inflammatory-nutritional state. We evaluated the association between serum fetuin-A levels and vascular calcification, intima-media thickness, and nutritional and inflammatory markers in different stages of chronic kidney disease (CKD).

Materials And Methods: CKD patients were sampled for calcium-phosphate parameters and nutritional and inflammatory markers [highly sensitive C-reactive protein (hs-CRP)], and serum fetuin-A levels. Read More

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http://dx.doi.org/10.3906/sag-1809-43DOI Listing
February 2019

[Methanaphylaxis of urolithiasis. Part 1. Factors for increasing incidence of urolithiasis. Current theories of renal stone formation].

Urologiia 2018 Oct(4):161-169

Urolithiasis is one of the most actively progressing diseases, a metabolic disorder that is strongly associated with a combination of genetic, lifestyle, and environmental factors. The first part presents current views on the factors triggering the formation of stones and the theory of stone formation. More specifically, the article discusses factors that contribute to the activation and inhibition of nucleation and aggregation of stone-forming substances. Read More

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October 2018

[Complications of percutaneous nephrolithotomy and their management].

Urologiia 2018 Oct(4):147-153

S.I. Spasokukotsky City Clinical Hospital, Moscow, Russia.

To date, percutaneous nephrolithotomy (PNL) is the standard treatment modality for large-volume renal stones and staghorn stones in patients with urolithiasis. Despite low invasiveness, this method is not without complications. This review discusses the most common complications and suggests methods for their prevention and appropriate management. Read More

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October 2018

[Nephron-sparing surgery for renal tumors].

Urologiia 2018 Oct(4):142-146

Republican Hospital , Yakutsk, Russia.

This review article presents the data on the epidemiology of renal cell carcinoma and describes minimally invasive surgery for this disease. The authors discuss the use of warm and cold ischemia, vascular microdissection, and artery embolization in renal tumor surgery, and analyze treatment outcomes. Read More

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October 2018

[Retroperitoneoscopic resection of the calyceal diverticulum wall in an 8-year-old child].

Urologiia 2018 Oct(4):130-134

Research Institute of Emergency Pediatric Surgery and Traumatology of MHD, Moscow, Russia.

A renal calyceal diverticulum is a cystic cavity within the renal parenchyma, which is lined by transitional epithelium and communicates with the calyx or, more rarely, the renal pelvis. In children, this anomaly is extremely rare. The article describes the resection of the middle calyceal diverticulum in an 8-year-old child using retroperitoneoscopic access. Read More

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October 2018

[Interstitial laser coagulation in the management of urothelial papillary carcinoma of the renal pelvis].

Urologiia 2018 Oct(4):122-126

Research Clinical Center of JSC RZD, Moscow, Russia.

This article presents a case of a 59-year-old patient with a primary tumor of the right kidney with bladder and liver metastases. The patient was treated in three-stages. In the first stage, he underwent ureteral stone extraction, laser resection of the tumor with subsequent vaporization. Read More

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October 2018

[Complete ileal substitution of the obliterated ureter].

Urologiia 2018 Oct(4):114-117

Omsk State Medical University of Minzdrav of Russia, Omsk, Russia.

The article presents the experience of successful surgical treatment of a patient with complete ureteral obliteration after transurethral endoscopic pyelolithotripsy in the left renal pelvis with lithoextraction and stenting. Two months later the patient developed stent obstruction and underwent repeat stenting and insertion of a left nephrostomy tube. After another 1. Read More

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October 2018

[Biological properties of microorganisms isolated from the urine of patients with urolithiasis].

Urologiia 2018 Oct(4):14-18

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the RAS, Orenburg, Russia.

Aim: To define persistent properties and antibiotic resistance of microorganisms isolated from the urine of adult patient undergoing surgery for urolithiasis.

Materials And Methods: Urine specimens were obtained from the renal pelvis and urinary bladder during percutaneous nephrolithotripsy. Microorganisms that were isolated from the urine were examined for their persistent properties (anti-lysozyme activity, the ability of biofilm formation) and antibiotic resistance using photometric and bacteriological methods. Read More

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October 2018

The diagnostic accuracy and clinical utility of pediatric renal tumor biopsy: Report of the UK experience in the SIOP UK WT 2001 trial.

Pediatr Blood Cancer 2019 Feb 13:e27627. Epub 2019 Feb 13.

Department of Cellular Pathology, University Hospital of Wales, Cardiff, UK.

Introduction: The International Society of Paediatric Oncology (SIOP) protocols recommend preoperative chemotherapy appropriate for Wilms tumors (WTs) in children with renal tumors aged ≥6 months, reserving biopsy for "atypical" cases. The Children's Cancer and Leukaemia Group (CCLG) joined the SIOP-WT-2001 study but continued the national practice of biopsy at presentation.

Method: Retrospective study of concordance between locally reported renal tumor biopsies and central pathology review nephrectomy diagnoses of children enrolled by CCLG centers in the SIOP-WT-2001 study. Read More

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http://dx.doi.org/10.1002/pbc.27627DOI Listing
February 2019

The Association Between Uric Acid, Renal Hemodynamics and Arterial Stiffness Over the Natural History of Type 1 Diabetes.

Diabetes Obes Metab 2019 Feb 13. Epub 2019 Feb 13.

Department of Medicine, Division of Nephrology, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.

Aims: Higher plasma uric acid (PUA) concentrations are associated with renal vasoconstriction, renin angiotensin aldosterone system (RAAS) activation and vascular stiffness, however the timeline for these associations in type 1 diabetes (T1D) is not clear. We aimed to compare the changes in such associations over a wide range of T1D duration.

Materials And Methods: PUA, glomerular filtration rate (GFR ), effective renal plasma flow (ERPF ), vascular stiffness parameters (aortic augmentation index [AIx], carotid AIx, carotid femoral pulse wave velocity [cfPWV]), plasma renin and aldosterone were measured during a euglycemic clamp in participants with T1D: 27 adolescents (age 16. Read More

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http://dx.doi.org/10.1111/dom.13665DOI Listing
February 2019
6.360 Impact Factor

The risk of mortality among people with type 2 diabetes mellitus in Latin America: A systematic review and meta-analysis of population-based cohort studies.

Diabetes Metab Res Rev 2019 Feb 13:e3139. Epub 2019 Feb 13.

CRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.

Type 2 Diabetes mellitus (T2DM) is associated with a high mortality risk, though the magnitude of this association remains unknown in Latin America (LA). We aimed to assess the strength of the association between T2DM and all-cause and cause-specific mortality in population-based cohort studies in LA. Systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1002/dmrr.3139DOI Listing
February 2019
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