662,629 results match your criteria Renal & Urology News [Journal]


Value of supranormal function on Tc-MAG3 scan in pediatric patients with obstructive hydronephrosis.

BJU Int 2019 Apr 23. Epub 2019 Apr 23.

Department of Pediatric Surgery, Pediatric Urology Division, Hospital Sant Joan de Déu. Universitat de Barcelona, Spain.

Objectives: To study related factors and clinical significance of supranormal function in pediatric patients with PUJ obstruction, and to predict which factors cause renal function overestimation.

Patients And Methods: Patients who underwent pyeloplasty from 2012 to 2017 were prospectively collected. Variables were compared between patients with and without supranormal function on 99mTc-MAG-3 scan (differential renal function ≥55%). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bju.14781DOI Listing

The value of cytoreductive nephrectomy on the survival of metastatic renal carcinoma patients based on the number of site-specific metastases.

PLoS One 2019 23;14(4):e0215861. Epub 2019 Apr 23.

Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: There has been significant uncertainty in the selection of candidates for cytoreductive nephrectomy (CN) in patients with metastatic renal cell carcinoma (mRCC). This report investigates the influence of site-specific metastases (bone, brain, liver, and lung) on the survival benefit of CN.

Methods: Within the Surveillance, Epidemiology and End Results database (2010-2014), 1113 mRCC patients treated with CN (n = 618) or no surgery (NS, n = 495) met the selection criteria. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215861PLOS
April 2019
1 Read

Activation of the calcium sensing receptor attenuates TRPV6-dependent intestinal calcium absorption.

JCI Insight 2019 Apr 23;5. Epub 2019 Apr 23.

Plasma calcium (Ca2+) is maintained by amending the release of parathyroid hormone and through direct effects of the Ca2+ sensing receptor (CaSR) in the renal tubule. Combined, these mechanisms alter intestinal Ca2+ absorption by modulating 1,25-dihydroxy vitamin D3 production, bone resorption, and renal Ca2+ excretion. The CaSR is a therapeutic target in the treatment of secondary hyperparathyroidism and hypocalcemia a common complication of calcimimetic therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/jci.insight.128013DOI Listing

Erythropoietin inhibits SGK1-dependent TH17 induction and TH17-dependent kidney disease.

JCI Insight 2019 Apr 23;5. Epub 2019 Apr 23.

IL-17-producing CD4+ cells (TH17) are pathogenically linked to autoimmunity including to autoimmune kidney disease. Erythropoietin's (EPO) newly recognized immunoregulatory functions and its predominant intra-renal source suggested that EPO physiologically regulates TH17 differentiation, thereby serving as a barrier to the development of autoimmune kidney disease. Using in vitro studies of human and murine cells and in vivo models, we show that EPO ligation of its receptor (EPO-R) on CD4+ T cells directly inhibits TH17 generation and promotes trans-differentiation of TH17 into IL-17-FOXP3+CD4+ T cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/jci.insight.127428DOI Listing

Experience with the HeartMate II Left Ventricular Assist Device in Patients Older than 60 Years.

Heart Surg Forum 2019 Mar 8;22(2):E124-E130. Epub 2019 Mar 8.

Division of Cardiothoracic Transplantation and Circulatory Support Baylor College of Medicine Houston, Texas, USA.

Background: Advanced age is a relative contraindication for heart transplantation, but no age cutoff has been defined for patients receiving mechanical circulatory support.

Methods: Between November 1, 2003 and November 1, 2012, we implanted the HeartMate II (HMII) left ventricular assist device (LVAD) in 319 patients. One hundred seven patients (89 men, 18 women) were over 60 years old (mean, 66 ± 4 years, range, 61-78 years) and received the HMII as a bridge to transplantation (n = 45) or as destination therapy (n = 62). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1532/hsf.2297DOI Listing

Delayed Surgical Management of Type A Intramural Hematoma Is Not Associated with Worse Outcomes Than Emergent Operation.

Heart Surg Forum 2019 Mar 4;22(2):E103-E106. Epub 2019 Mar 4.

Division of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Objectives: Management of acute aortic intramural hematomas (IMHs) involving the ascending aorta and root remains controversial. Some series have suggested that delaying operative intervention beyond the first 24-hours may be beneficial.

Methods: A retrospective single-institution analysis was performed to identify patients presenting with type A IMH. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1532/hsf.2289DOI Listing

FATTY KIDNEY DISEASE: A NEW RENAL AND ENDOCRINE CLINICAL ENTITY? DESCRIBING THE ROLE OF THE KIDNEY IN OBESITY, METABOLIC SYNDROME AND TYPE 2 DIABETES.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

Both authors have no conflicts of interest for this manuscript and contributed equally to its writing.

Objective: To determine whether fatty kidney disease deserves be designated as a distinct clinical entity similar to fatty liver disease.

Methods: Analysis and interpretation of the literature in a novel conceptual framework.

Results: The kidney contributes to hyperglycemia, hypertension, inflammatory cytokines, and thus to diabetes and metabolic syndrome. Read More

View Article

Download full-text PDF

Source
http://journals.aace.com/doi/10.4158/EP-2018-0568
Publisher Site
http://dx.doi.org/10.4158/EP-2018-0568DOI Listing

Mangosteen Vinegar Rind from Garcinia mangostana Prevents High-Fat Diet and Streptozotocin-Induced Type II Diabetes Nephropathy and Apoptosis.

J Food Sci 2019 Apr 23. Epub 2019 Apr 23.

Biomedical Sciences, School of Allied Health Sciences, Walailak Univ., Nakhon Si Thammarat, 80161, Thailand.

Type II diabetes (T2D) nephropathy, a major cause of end-stage kidney disease, progresses and develops from oxidative stress. Natural polyphenols can protect the kidney from diabetic nephropathy exerting antioxidant activities. The present approach enumerates the reno-protective and anti-apoptotic effects of mangosteen vinegar rind (MVR, a phenolic aqueous extract) against high-fat diet (5 g/day up to five weeks)-/streptozotocin (single ip, dose 30 mg/kgBW)-induced T2D nephropathy of albino mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1750-3841.14511DOI Listing

Endocytic recycling and vesicular transport systems mediate transcytosis of across cell monolayer.

Elife 2019 Apr 23;8. Epub 2019 Apr 23.

Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, China.

Many bacterial pathogens can cause septicemia and spread from the bloodstream into internal organs. During leptospirosis, individuals are infected by contact with -containing animal urine-contaminated water. The spirochetes invade internal organs after septicemia to cause disease aggravation, but the mechanism of leptospiral excretion and spreading remains unknown. Read More

View Article

Download full-text PDF

Source
https://elifesciences.org/articles/44594
Publisher Site
http://dx.doi.org/10.7554/eLife.44594DOI Listing

Long term control and preservation of renal function after multiple courses of stereotactic body radiation therapy for renal cell carcinoma.

Can J Urol 2019 Apr;26(2):9743-9745

Transitional Year Program, Riverside Regional Medical Center, Newport News, Virginia, USA.

Renal cell carcinoma (RCC) is usually treated with surgery, with or without systemic therapy. For select patients, stereotactic body radiation therapy (SBRT) may be a suitable alternative. Although many reports exist on the successful use of SBRT, very few have described long term outcomes with regard to disease progression and renal function. Read More

View Article

Download full-text PDF

Source

Ex-vivo donor partial nephrectomy at the time of donor-directed renal transplantation.

Can J Urol 2019 Apr;26(2):9740-9742

Department of Urology, Ochsner Health System, New Orleans, Louisiana, USA.

The outcome of nephron-sparing surgical management of small renal masses is generally favorable, specifically in terms of long term renal function, overall survival, and oncologic outcomes. Given the overall prognosis and renal function preservation, transplantation of kidneys with small renal masses has increasingly been accepted as a donor option for renal transplantation. We present a case of an incidental renal mass on preoperative donor transplant evaluation and subsequent ex-vivo donor partial nephrectomy at the time of renal transplantation. Read More

View Article

Download full-text PDF

Source

Factors associated with prolonged length of stay following robotic-assisted partial nephrectomy.

Can J Urol 2019 Apr;26(2):9726-9732

Department of Urology, Mayo Clinic, Jacksonville, Florida, USA.

Introduction: To prospectively analyze the association of clinical and operative variables on patient length of hospital stay (LOS) following robotic-assisted partial nephrectomy (RAPN) and develop an accurate clinical-based scoring system to predict prolonged LOS following RAPN.

Materials And Methods: We analyzed 304 consecutive RAPNs performed by a single surgeon. Prolonged LOS was defined as greater than 3 days of hospitalization postoperatively. Read More

View Article

Download full-text PDF

Source

Prognostic implications of renal vein involvement in T3a renal cancer.

Can J Urol 2019 Apr;26(2):9715-9719

Urologic Surgery, Charleston Area Medical Center, Charleston, West Virginia, USA.

Introduction: The TNM staging system is used globally as the standard for interpreting the extent of cancer. Currently, T3a renal cell carcinoma is classified as tumor extending into the perinephric fat or renal vein. Prognostic outcomes may vary among renal cell carcinomas with renal vein involvement (RVI) versus those with perinephric fat involvement (PFI). Read More

View Article

Download full-text PDF

Source

Intraocular Concentrations of Cytokines and Chemokines in a Unique Case of Nivolumab-Induced Uveitis.

Ocul Immunol Inflamm 2019 Apr 23:1-4. Epub 2019 Apr 23.

a Department of Ophthalmology , Tohoku University Graduate School of Medicine , Sendai , Japan.

Purpose: To report a unique case of nivolumab-induced uveitis and the results of a cytokine analysis of an intraocular fluid sample.

Case Report: A 61-year-old male patient undergoing treatment for renal cell carcinoma with nivolumab presented with bilateral uveitis. Severe anterior uveitis and vitreous opacity coincided with decreased visual acuity only in his left eye. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09273948.2019.1582785DOI Listing

Management of BK-virus infection - Swedish recommendations.

Infect Dis (Lond) 2019 Apr 23:1-6. Epub 2019 Apr 23.

k Department of Infectious Diseases , Karolinska University Hospital , Stockholm , Sweden.

BK-virus (BKV) associated nephropathy (BKVAN) and BKV associated haemorrhagic cystitis (HC) are complications of BKV infection/reactivation in renal and allogeneic haematopoietic stem cell transplantation (HSCT) patients, respectively. The task of how to manage these diseases was given to the chair by the Swedish Reference Group for Antiviral Therapy (RAV). After individual contributions by members of the working group, consensus discussions were held in a meeting on 23 January 2018 arranged by RAV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/23744235.2019.1595130DOI Listing

Aluminum oxide nanoparticles mediated toxicity, loss of appendages in progeny of Drosophila melanogaster on chronic exposure.

Nanotoxicology 2019 Apr 23:1-13. Epub 2019 Apr 23.

a Neurobiology Division , Defence Institute of Physiology and Allied Sciences , Delhi , India.

Aluminum oxide (AlO) nanoparticles (NPs) have a wide number of applications which cause intentional and unintentional exposure to humans, making it important to understand the nano-bio interaction. In this study, we made an attempt to evaluate the toxic effects of AlO NPs chronic exposure on Drosophila melanogaster. Flies were exposed to AlO NPs at concentration 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17435390.2019.1602680DOI Listing

Percutaneous glue embolization as a primary treatment for visceral pseudoaneurysms.

Minim Invasive Ther Allied Technol 2019 Apr 23:1-7. Epub 2019 Apr 23.

a Department of Radio Diagnosis , Post Graduate Institute of Medical Education and Research , Chandigarh , India.

Aim: To evaluate the feasibility and outcome of percutaneous glue embolisation as primary treatment for pseudoaneurysms in selective patients.

Material And Methods: A review of the pseudoaneurysm cases managed with percutaneous glue at our institute was analyzed in this study. A total of 21 patients over a period of last one year who were treated for pseudoaneurysm at varied sites primarily with percutaneous n-butyl cynoacrylate were retrospectively evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13645706.2019.1606019DOI Listing

Utility of CT Radiomics Features in Differentiation of Pancreatic Ductal Adenocarcinoma From Normal Pancreatic Tissue.

AJR Am J Roentgenol 2019 Apr 23:1-9. Epub 2019 Apr 23.

1 The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287.

The objective of our study was to determine the utility of radiomics features in differentiating CT cases of pancreatic ductal adenocarcinoma (PDAC) from normal pancreas. In this retrospective case-control study, 190 patients with PDAC (97 men, 93 women; mean age ± SD, 66 ± 9 years) from 2012 to 2017 and 190 healthy potential renal donors (96 men, 94 women; mean age ± SD, 52 ± 8 years) without known pancreatic disease from 2005 to 2009 were identified from radiology and pathology databases. The 3D volume of the pancreas was manually segmented from the preoperative CT scans by four trained researchers and verified by three abdominal radiologists. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2214/AJR.18.20901DOI Listing

The clinical significance of antinuclear antibodies and specific autoantibodies in juvenile and adult systemic lupus erythematosus patients.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Center of Excellence in Immunology and Immune-mediated Diseases, Department of Microbiology.

Background: Juvenile systemic lupus erythematosus (JSLE) and adult SLE (ASLE) patients present with different clinical manifestations, but it is unknown if there are differences in their antinuclear autoantibody (ANA) profiles or if staining patterns are associated with specific autoantibodies and clinical manifestations.

Objective: To determine whether distinct types and numbers of ANA-staining patterns are associated with specific autoantibodies and clinical manifestations in JSLE and ASLE patients.

Methods: A retrospective study was performed in Thai children (n = 146) and adults (n = 180) diagnosed with SLE using the Systemic Lupus International Collaborating Clinics classification criteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12932/AP-211218-0465DOI Listing

Treatment of advanced pediatric renal cell carcinoma.

Pediatr Blood Cancer 2019 Apr 23:e27766. Epub 2019 Apr 23.

Division of Oncology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.

Background: Pediatric renal cell carcinoma (pRCC) is the second most common renal malignancy of childhood; however, treatment data for advanced disease is lacking.

Methods: A retrospective analysis of pRCC patients (age < 21 years at diagnosis) treated between 2000 and 2015 at Cincinnati Children's Hospital Medical Center was undertaken, with specific focus on medical therapies, accompanied by a detailed literature review.

Results: Twenty-four patients (median age = 15 years) were identified; 11 were female. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.27766DOI Listing

Safety and efficacy of eculizumab for the prevention of antibody-mediated rejection after deceased-donor kidney transplantation in patients with preformed donor-specific antibodies.

Am J Transplant 2019 Apr 23. Epub 2019 Apr 23.

Formerly Alexion Pharmaceuticals, Boston, Massachusetts.

The presence of preformed donor-specific antibodies (DSAs) in transplant recipients increases risk of acute antibody-mediated rejection (AMR). Results of an open-label, single-arm trial to evaluate safety and efficacy of eculizumab in preventing acute AMR in recipients of deceased-donor kidney transplants with preformed DSAs are reported. Participants received eculizumab as follows: 1200 mg immediately before reperfusion, 900 mg on posttransplantation days 1, 7, 14, 21 and 28, and 1200 mg at weeks 5, 7 and 9. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajt.15397DOI Listing

Time for Reform in Transplant Program Specific Reporting - AST/ASTS Transplant Metrics Taskforce.

Am J Transplant 2019 Apr 23. Epub 2019 Apr 23.

Division of Transplantation, University of Minnesota, Minneapolis, Minnesota.

In accordance with the National Organ Transplant Act and HHS's Final Rule, the Scientific Registry of Transplant Recipients (SRTR) publicly releases biannual program-specific reports which include analyses of transplant centers' risk-adjusted wait-list mortality, organ acceptance ratios, transplant rates, and graft and patient survival. Since the inception of these center metrics, one-year post-transplant graft and patient survival have improved, and center variation has decreased, casting uncertainty on their clinical relevance. The SRTR has recently modified center evaluations by ranking centers into 5 tiers rather than 3-tiers in an attempt to discriminate between programs performing within a tight range, further exacerbating this uncertainty. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajt.15394DOI Listing

Contrast enhancement ultrasound of renal perfusion in dogs with acute kidney injury.

J Small Anim Pract 2019 Apr 22. Epub 2019 Apr 22.

Department of Veterinary Sciences, University of Pisa - Via Livornese, 56122, Pisa, Italy.

Objective: To evaluate the efficacy of contrast-enhanced ultrasound to assess changes in renal perfusion in dogs with acute kidney injury.

Materials And Methods: The left kidney of each dog in two groups was examined using contrast-enhanced ultrasound: Group A consisted of 16 healthy dogs and Group B consisted of 12 dogs with acute kidney injury.

Results: All dogs in Group A showed the same sequence of wash-in and wash-out. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jsap.13001DOI Listing

Cytokine profile, Treg/Th17 cell frequency changes during different posttransplantational time points in patients undergoing renal transplantation.

J Cell Physiol 2019 Apr 22. Epub 2019 Apr 22.

Stem Cells Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Renal transplantation is the best therapeutic approach for end stage renal dysfunction patients. There are direct relationships between proportions of Treg cells, Treg/Th17 cells ratio and secreted immunosuppressive cytokines with increased survival rate of the transplanted organ. The aim of this study was the measurement of Treg and Th17 cells frequency and their secreted cytokines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.28698DOI Listing

Correlation of serum galectin-3 level with renal volume and function in adult polycystic kidney disease.

Int Urol Nephrol 2019 Apr 22. Epub 2019 Apr 22.

Department of Biostatistics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.

Purpose: The decrease in kidney functions in autosomal dominant polycystic kidney disease (ADPKD) is strongly correlated with the severity and growth of kidney cysts. Total kidney volume (TKV) was shown to be an early marker of the severity of the disease and a predictor of reduction in kidney functions. New treatment approaches for ADPKD have led to a need for easily applicable strong biomarkers predicting progression of the disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02156-8DOI Listing

Mitochondrial TRPC3 promotes cell proliferation by regulating the mitochondrial calcium and metabolism in renal polycystin-2 knockdown cells.

Int Urol Nephrol 2019 Apr 22. Epub 2019 Apr 22.

Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, No.95 Yong'an Road, Xicheng District, Beijing, 100050, China.

Purpose: Previous studies indicate that autosomal dominant polycystic kidney disease (ADPKD) cells exhibited dysregulated calcium homeostasis and enhanced cell proliferation. TRPC3 has been shown to function in the modulation of calcium and sodium entry, but whether TRPC3 plays a role in cellular abnormalities of ADPKD cells has not been defined.

Methods: Human conditionally immortalized proximal tubular epithelial cells and mouse IMCD3 cells were used with polycystin-2 (PC2, TRPP2) knockdown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02149-7DOI Listing

Pentosidine in chronic hemodialysis patients: relation with arteriovenous fistula morphology and function.

Int Urol Nephrol 2019 Apr 22. Epub 2019 Apr 22.

Department of Nephrology, "Iuliu Haţieganu" University of Medicine and Pharmacy, 3-5 Clinicilor Street, 400006, Cluj-Napoca, Romania.

Purpose: It has been suggested that advanced glycation end products (AGEs) are involved in atherogenesis, vascular calcification and remodeling, including neointimal hyperplasia, in renal and non-renal patients. Their relevance for arteriovenous fistula (AVF) function has been poorly studied to date, with only one clinical study addressing the issue of thrombosis of vascular access in relation to AGEs in dialysis patients. We aimed to evaluate the relationship between serum pentosidine and AVF morphology and function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02151-zDOI Listing

Treatment guidelines for persistent cloaca, cloacal exstrophy, and Mayer-Rokitansky-Küster-Häuser syndrome for the appropriate transitional care of patients.

Surg Today 2019 Apr 22. Epub 2019 Apr 22.

Research Team for the Establishment of Treatment Guidelines for Persistent Cloaca, Cloacal Exstrophy and Mayer-Rokitansky-Küster-Häuser Syndrome for the Proper Transitional Care of the Patients, The Research Project for Rare and Intractable Diseases of the Ministry of Health, Labour and Welfare (MHLW), Tokyo, Japan.

We developed treatment guidelines (TGs) for appropriate transitional care of the genitourinary system in patients with persistent cloaca (PC), cloacal exstrophy (CE), or Mayer-Rokitansky-Küster-Häuser syndrome (MRKH). These TGs are in accordance with the Medical Information Network Distribution Service (Minds), published in 2014 in Japan. Clinical questions (CQs) concerning treatment outcomes of the genitourinary system, pregnancy and delivery, and quality of life in adulthood were prepared as six themes for PC and CE and five themes for MRKH. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00595-019-01810-zDOI Listing

Association of the early absolute CD64-expressing neutrophil count and sepsis outcome.

Eur J Clin Microbiol Infect Dis 2019 Apr 23. Epub 2019 Apr 23.

2nd Department of Intensive Care Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.

To evaluate the early absolute CD64/CD15/CD45 neutrophil count as a marker of prognosis of sepsis outcome the absolute CD64/CD15/CD45 count was measured by flow cytometry in 65 patients with confirmed or suspected Gram-negative sepsis and organ dysfunction. Serum interleukin(IL)-8 and interferon-gamma (IFNγ) were measured by an enzyme immunoassay. An absolute count lower than 2500 cells/mm could early discriminate non-survivors with sensitivity 82. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10096-019-03507-0DOI Listing

Exposure to vitamin k antagonists and kidney function decline in patients with atrial fibrillation and chronic kidney disease.

Res Pract Thromb Haemost 2019 Apr 5;3(2):207-216. Epub 2019 Mar 5.

Thrombosis Research Unit Department of Medicine I Division of Hematology University Hospital "Carl Gustav Carus" Dresden Dresden Germany.

Background: Exposure to vitamin K antagonists (VKA) has been suggested to accelerate progression of chronic kidney disease (CKD) but robust clinical data are currently lacking.

Methods: We retrospectively evaluated the impact of VKA exposure on kidney function in patients with atrial fibrillation (AF) and CKD stage 3/4. Patients were prospectively followed within a primary care electronic database (median follow-up of 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/rth2.12189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462762PMC

Fibrinogen αC domain: Its importance in physiopathology.

Res Pract Thromb Haemost 2019 Apr 15;3(2):173-183. Epub 2019 Feb 15.

Laboratoire de recherche en Onco-Hématologie Hôtel Dieu de Paris Paris France.

Abstract: Fibrinogen, involved in coagulation, is a soluble protein composed of two sets of disulfide-bridged Aα, Bβ, and γ-chains. In this review, we present the clinical implications of the αC domain of the molecule in Alzheimer's disease, hereditary renal amyloidosis and a number of thrombotic and hemorrhagic disorders. In Alzheimer's disease, amyloid beta peptide (Aβ) is increased and binds to the αC domain of normal fibrinogen, triggering increased fibrin(ogen) deposition in patients' brain parenchyma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/rth2.12183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462745PMC

Cystatin C Is an Important Biomarker for Cardiovascular Autonomic Dysfunction in Chinese Type 2 Diabetic Patients.

J Diabetes Res 2019 18;2019:1706964. Epub 2019 Mar 18.

Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Guangzhou, Guangdong 510630, China.

Background: Cardiovascular autonomic dysfunction is closely related to increased mortality in patients with diabetes. Previous studies have proved that cystatin C (CysC) is an important predictor of both peripheral neuropathy and cardiovascular events. However, whether CysC is also associated with cardiovascular autonomic dysfunction remains unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/1706964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442484PMC

Acute oral toxicity evaluation of extracts of in wister albino rats as per OECD 425 TG.

Toxicol Rep 2019 4;6:321-328. Epub 2019 Apr 4.

Department of Pharmacology, College of Pharmaceutical Sciences, Dayananda Sagar University, Shavige Malleshwara Hills, Kumaraswamy Layout, Bengaluru, Karnataka, 560078, India.

(Family: Apiaceae) is a medicinal plant and is been a part of traditional cuisine. Hence, an acute toxicity study was performed to confirm its safety profile. Female rats (n=5) were randomly divided into 5 groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxrep.2019.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460325PMC

A Case Study of Malrotated Kidneys with Asymmetric Multiple Renal Arteries, Variant Venous Drainage, and Unilateral Ureteral Duplication.

Case Rep Vasc Med 2019 18;2019:1893137. Epub 2019 Mar 18.

Department of Anatomy and Cell Biology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.

Variations in the arterial, venous, and ureteral patterning of the right (r) and left (l) kidneys are common; however, concomitant involvement with all three systems is rare. Specimens that demonstrate anatomic variation across multiple systems provide an opportunity to illustrate links between anatomic concepts, embryologic development, clinical practice, and education. During anatomic study of the abdominal cavity, a total of five major arteries (3l and 2r) emerged from the aortic and common iliac axes in a cadaveric donor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/1893137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442374PMC

Postinfectious Acute Glomerulonephritis in Renal Transplantation: An Emergent Aetiology of Renal Allograft Loss.

Case Rep Transplant 2019 18;2019:7438254. Epub 2019 Mar 18.

Department of Nephrology and Renal Transplantation, Hospital Clínic, University of Barcelona, IDIBAPS, Barcelona, Spain.

Despite the high incidence of posttransplant infections, postinfectious acute glomerulonephritis (PIAGN) in renal allograft is a rare entity, without effective treatment and a bad prognosis. We describe two cases of PIAGN: the first one was developed 2 years after kidney transplantation, secondary to bacteremia with presence of extracapillary proliferation in biopsy. The patient was treated with methylprednisolone and plasma exchanges without response, remaining dialysis dependent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/7438254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442439PMC

A new reconstructive technique for select patients with long upper ureteral obliteration.

Cent European J Urol 2019 29;72(1):54-56. Epub 2019 Jan 29.

Department of Urology, E. Wolfson Medical Center, Holon, Israel, affiliated with the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Ureteral reconstructions pose a challenge for urologists. We describe a novel reconstructive technique for long upper ureteral obliteration with an intrarenal pelvis. The obliterated ureteral segment was excised and the healthy segment of the ureter was spatulated and anastomosed end-to-side to the intrarenal lower calyx (ureterocalycostomy). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5173/ceju.2018.1759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469001PMC
January 2019

Tadalafil vs. tamsulosin in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia: a prospective, randomized study.

Cent European J Urol 2019 14;72(1):44-50. Epub 2019 Mar 14.

Department of Urology and Renal Transplantation, Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India.

Introduction: To compare the efiicacy of tadalafil 5 mg with tamsulosin 0.4 mg in the treatment of Lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH).

Material And Methods: A randomized prospective study on patients diagnosed with LUTS secondary to BPH with 50 patients in each group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5173/ceju.2019.1570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469005PMC

Prognostic value of B7-H1, B7-H3 and the stage, size, grade and necrosis (SSIGN) score in metastatic clear cell renal cell carcinoma.

Cent European J Urol 2019 14;72(1):23-31. Epub 2019 Mar 14.

Department of Urology, Medical University of Graz, Graz, Austria.

Introduction: We compared the potential prognostic impact of B7-H1 and B7-H3 glycoprotein expressions with the Mayo Clinic Stage, Size, Grade, and Necrosis (SSIGN) score in metastatic clear cell renal cell carcinoma (mccRCC) during a long term follow-up.

Material And Methods: We investigated 44 mccRCC patients, who underwent radical nephrectomy between 1995 and 2006 at a single tertiary academic center and received interferon therapy (IFNT) for at least three months. The SSIGN score was applied as a validated prediction outcome model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5173/ceju.2018.1858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469004PMC

Complete Response to Chemotherapy against the Recurrence of Neuroendocrine Carcinoma of the Breast in the Anterior Mediastinal Lymph Nodes of a Patient on Hemodialysis: A Case Report.

Case Rep Oncol 2019 Jan-Apr;12(1):205-210. Epub 2019 Feb 28.

Department of Surgery, Yoshida General Hospital, Akitakata, Japan.

In general, the cancer-bearing rate of patients on dialysis is considered to be higher than that of healthy individuals. There is no established chemotherapy regimen for patients on hemodialysis (HD), but some reports have described chemotherapy administration in such patients according to HD conditions, residual renal function, and the drug metabolic pathway. We present a case involving a 76-year-old female patient on HD who underwent chemotherapy for mediastinal lymph node recurrence of neuroendocrine carcinoma of the breast (NECB) using 5-fluorouracil, epirubicin, and cyclophosphamide (FEC 100) and docetaxel (DTX). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000497479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465717PMC
February 2019

Management Approaches to Hepatitis B Virus Vaccination Nonresponse.

Gastroenterol Hepatol (N Y) 2019 Feb;15(2):93-99

Dr Yanny is a health science clinical instructor of medicine and Mr Konyn is a medical student in the Department of Medicine at the University of California at Los Angeles in Los Angeles, California. Ms Najarian is a premedical student in the Department of Surgery at the University of California at Los Angeles. Ms Mitry is a graduate student at Claremont Graduate University in Riverside, California.

Despite the availability of hepatitis B virus (HBV) vaccination, HBV remains a cause of significant morbidity and mortality around the world. Immunologic response and the development of immunity to the HBV vaccine vary significantly among patients. Multiple studies have looked at patients who are at risk of nonresponse and have offered their own approaches to patients who do not respond. Read More

View Article

Download full-text PDF

Source
February 2019

A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.

Nat Med 2019 Apr 22. Epub 2019 Apr 22.

Research Division, Joslin Diabetes Center, Boston, MA, USA.

Chronic inflammation is postulated to be involved in the development of end-stage renal disease in diabetes, but which specific circulating inflammatory proteins contribute to this risk remain unknown. To study this, we examined 194 circulating inflammatory proteins in subjects from three independent cohorts with type 1 and type 2 diabetes. In each cohort, we identified an extremely robust kidney risk inflammatory signature (KRIS), consisting of 17 proteins enriched in tumor necrosis factor-receptor superfamily members, that was associated with a 10-year risk of end-stage renal disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41591-019-0415-5DOI Listing

Duration of Dual Antiplatelet Therapy in Patients with CKD and Drug-Eluting Stents: A Meta-Analysis.

Clin J Am Soc Nephrol 2019 Apr 22. Epub 2019 Apr 22.

Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Background And Objectives: Whether prolonged dual antiplatelet therapy (DAPT) is more protective in patients with CKD and drug-eluting stents compared with shorter DAPT is uncertain. The purpose of this meta-analysis was to examine whether shorter DAPT in patients with drug-eluting stents and CKD is associated with lower mortality or major adverse cardiovascular event rates compared with longer DAPT.

Design, Setting, Participants, & Measurements: A Medline literature research was conducted to identify randomized trials in patients with drug-eluting stents comparing different DAPT duration strategies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2215/CJN.12901018DOI Listing

Urothelial carcinoma with an NRF1/BRAF rearrangement and response to targeted therapy.

Cold Spring Harb Mol Case Stud 2019 Apr 22. Epub 2019 Apr 22.

University of Iowa Hospitals and Clinics

Although BRAF mutations are commonly identified in many solid tumors and the response of BRAF p.V600E-positive tumors to targeted therapy is well documented, BRAF rearrangements have only been reported in fewer than 60 casesare less frequent, predominantly found in low-grade glioma, melanoma, lung, colorectal, and thyroid carcinoma. The response of tumors harboring BRAF fusion to anti-BRAF therapy was unclear Preclinical and clinical studies have demonstrated effectiveness of multiple therapies (RAF-targeted, ERK-targeted, or MEK-targeted) targeting BRAF-fusion harboring tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/mcs.a003848DOI Listing

Prevalence and Prognosis of Unrecognized Myocardial Infarction in Asymptomatic Patients With Diabetes: A Two-Center Study With Up to 5 Years of Follow-up.

Diabetes Care 2019 Apr 22. Epub 2019 Apr 22.

Duke Cardiovascular Magnetic Resonance Center and Division of Cardiology, Duke University Medical Center, Durham, NC.

Objective: To determine the prevalence and prognostic significance of unrecognized myocardial infarction (MI) by delayed-enhancement MRI (DE-MRI) in asymptomatic patients with diabetes.

Research Design And Methods: Prospective, two-center study of asymptomatic patients without known cardiac disease ( = 120). Two prespecified cohorts underwent a research MRI: ) a high-risk group with type 1 diabetes and chronic renal insufficiency ( = 50) and ) an average-risk group with type 2 diabetes ( = 70). Read More

View Article

Download full-text PDF

Source
http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-226
Publisher Site
http://dx.doi.org/10.2337/dc18-2266DOI Listing

Treatment of γ-Hydroxybutyric Acid (GHB) and γ-Butyrolactone (GBL) Overdose with Two Potent Monocarboxylate Transporter 1 (MCT1) Inhibitors, AZD3965 and AR-C155858.

J Pharmacol Exp Ther 2019 Apr 22. Epub 2019 Apr 22.

University at Buffalo

The illicit use of γ-hydroxybutyric acid (GHB), and its prodrug, γ-butyrolactone (GBL), results in severe adverse effects including sedation, coma, respiratory depression and death. Current treatment of GHB/GBL overdose is limited to supportive care. Recent reports indicate that GHB-related deaths are on the rise; a specific treatment may reduce lethality associated with GHB/GBL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.119.256503DOI Listing

Comparison of organ donation and transplantation rates between opt-out and opt-in systems.

Kidney Int 2019 Mar 15. Epub 2019 Mar 15.

Department of Nephrology and Transplantation, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK. Electronic address:

Studies comparing opt-out and opt-in approaches to organ donation have generally suggested higher donation and transplantation rates in countries with an opt-out strategy. We compared organ donation and transplantation rates between countries with opt-out versus opt-in systems to investigate possible differences in the contemporary era. Data were analysed for 35 countries registered with the Organisation for Economic Co-operation and Development (17 countries classified as opt-out, 18 classified as opt-in) and obtained organ donation and transplantation rates for 2016 from the Global Observatory for Donation and Transplantation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.kint.2019.01.036DOI Listing

An Update on Predictive Biomarkers in Metastatic Renal Cell Carcinoma.

Eur Urol Focus 2019 Apr 19. Epub 2019 Apr 19.

Division of Medical Oncology, Department of Oncology, Tom Baker Cancer Centre, University of Calgary, Calgary, Canada. Electronic address:

One of the major challenges of personalized oncology lies in identifying predictive biomarkers of response to therapy that are practical in the clinical setting. Although many new targeted and immune-based treatments have emerged in recent years as effective systemic therapy options in metastatic renal cell carcinoma (mRCC), optimizing the selection and sequencing of treatments for any individual patient with this disease remains a significant challenge. The CheckMate-214 trial demonstrated that the International mRCC Database Consortium risk model is an effective predictive biomarker in the first-line treatment of mRCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.euf.2019.04.004DOI Listing
  • Page 1 of 13253