652,401 results match your criteria Renal & Urology News [Journal]


[Recommendations from a panel of experts on the usefulness of fidaxomicin for the treatment of infections caused by Clostridium difficile].

Rev Esp Quimioter 2018 Dec 13. Epub 2018 Dec 13.

Benito Almirante, Servicio de Enfermedades Infecciosas, Hospital Universitario Vall d'Hebron Passeig de la Vall d'Hebron, 119-129 - 08035 Barcelona, Spain.

Objective: Clostridium difficile infections have a high recurrence rate, which can complicate the prognosis of affected patients. It is therefore important to establish an early detection and an appropriate therapeutic strategy. The objective of this manuscript was to gather the opinion of an expert group about the predictive factors of poor progression, as well as when to use fidaxomicin in different groups of high-risk patients. Read More

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December 2018

Renal toxicity of heavy metals (cadmium and mercury) and their amelioration with ascorbic acid in rabbits.

Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.

Department of Veterinary Biomedical Sciences, PMAS Arid Agriculture University, Rawalpindi, PK-46300, Pakistan.

Cadmium and mercury are among the most toxic and dangerous environmental pollutants that may cause fatal implications. Vitamin C is an important chain-breaking antioxidant and enzyme co-factor against heavy metals. The objective of the present study was to evaluate the toxicological effects of cadmium chloride, mercuric chloride, and their co-administration on biochemical parameters of blood serum and metal bioaccumulation in kidneys and also to elucidate the protective effect of vitamin C in rabbits against these metals. Read More

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December 2018

Correction to: Impaired endogenous nighttime melatonin secretion relates to intrarenal renin-angiotensin system activation and renal damage in patients with chronic kidney disease.

Clin Exp Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Internal Medicine 1, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

In the original publication, an error occurred in Table 4 (B), under Nighttime group. The value of "Nighttime Log U-AGT/Cr" for model 3 (under R = 0.68) was incorrectly published as 0. Read More

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December 2018

Effects of long-term treatment with low-GDP, pH-neutral solutions on peritoneal membranes in peritoneal dialysis patients.

Clin Exp Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Department of Nephrology and Rheumatology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.

Background: The morphological changes induced by bio-incompatible peritoneal dialysis (PD) solutions are well known. However, the morphological damage induced by long-term low-glucose degradation product (GDP), pH-neutral solutions has not been reported in detail. The aim of this study was to investigate the long-term effects of pH-neutral PD solutions on morphological and functional changes in the peritoneal membrane. Read More

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December 2018

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria.

Diabetologia 2018 Dec 13. Epub 2018 Dec 13.

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Aims/hypothesis: Identifying rare coding variants associated with albuminuria may open new avenues for preventing chronic kidney disease and end-stage renal disease, which are highly prevalent in individuals with diabetes. Efforts to identify genetic susceptibility variants for albuminuria have so far been limited, with the majority of studies focusing on common variants.

Methods: We performed an exome-wide association study to identify coding variants in a two-stage (discovery and replication) approach. Read More

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December 2018

Role of platelets in thrombin generation amongst patients with non-transfusion-dependent thalassaemia.

Ann Hematol 2018 Dec 13. Epub 2018 Dec 13.

Department of Haematology, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore.

Non-transfusion-dependent thalassaemia (NTDT) is associated with a hypercoagulable state with thrombotic risk highest after splenectomy. Various mechanisms have been proposed. Although an antiplatelet agent is commonly recommended as thromboprophylaxis in NTDT, the role of platelets contributing to this hypercoagulable state is not well-defined. Read More

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December 2018

Segmental replacement to treat abdominal aortic aneurysm with bilateral accessory renal artery.

J Vasc Surg Cases Innov Tech 2018 Dec 4;4(4):305-306. Epub 2018 Dec 4.

Department of Cardiovascular Surgery, Hokkaido Prefectural Kitami Hospital, Kitami, Hokkaido, Japan.

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December 2018

Aortic endograft explantation in the setting of prior heterotopic renal allograft.

J Vasc Surg Cases Innov Tech 2018 Dec 4;4(4):275-277. Epub 2018 Dec 4.

Division of Vascular Surgery, University of Rochester, Rochester, NY.

It is rare to require explantation of an aortic endograft placed for endovascular aneurysm repair (EVAR). Sustained aneurysm growth in the setting of prior endovascular repair, despite secondary interventions and use of adjuncts, is the most common cause of EVAR explantation. An infected endograft and aneurysm rupture after EVAR represent more urgent or emergent indications for explantation and have a significantly greater associated morbidity and mortality. Read More

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December 2018

Utility of the claw sign in spine magnetic nuclear resonance with diffusion to differentiate Modic type I changes for degenerative disease versus infection.

J Spine Surg 2018 Sep;4(3):616-623

Neuroradiology Service, Central Military Hospital, Bogotá DC, Colombia.

Background: In 1988, Modic and his colleagues described changes in the subchondral bone marrow of the vertebral plates in patients with degenerative disease or other pathologies, which were observed in the nuclear magnetic resonance (NMR) of the spine and were subdivided into three patterns of signal changes, called Modic type I, Modic type II and Modic type III. The main differential diagnosis of the Modic I changes of the vertebral plates due to degenerative disease in spine NMR, is infection in its early stages. In their study in 2014, Patel and collaborators, using a protocol and the concept of diffusion in spine MRI, were able to demonstrate that by means of the "claw sing", a degenerative disease with Modic type I changes, can be differentiated from an infection in early stages. Read More

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September 2018

1000 consecutive ablation sessions in the era of computer assisted image guidance - Lessons learned.

Eur J Radiol Open 2019 5;6:1-8. Epub 2018 Dec 5.

Dept of Surgery and Urology, Danderyd University Hospital, Stockholm, Sweden.

Background: Ablation therapies for tumours are becoming more used as ablation modalities evolve and targeting solutions are getting better. There is an increasing body of long-term results challenging resection and proving lower morbidities and costs. The aim of this paper is to share the experiences from a high-volume centre in introducing computer assisted targeting solutions and efficient ablation modalities like microwave generators and irreversible electroporation. Read More

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December 2018

Patient-derived xenograft model for uterine leiomyoma by sub-renal capsule grafting.

J Biol Methods 2018 16;5(2). Epub 2018 Apr 16.

Department of Cancer Biology and Genetics, The Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA.

Uterine leiomyoma (UL) or fibroid is a benign smooth muscle tumor of the myometrium with a lifetime incidence of approximately 70%. ULs often require medical intervention due to severe symptoms such as heavy menstrual bleeding and abdominal pain. Although the most common and effective management of ULs is surgical removal, the invasive surgical procedure imposes physical and psychological burdens on the patients. Read More

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Tumor-infiltrating neutrophils predict therapeutic benefit of tyrosine kinase inhibitors in metastatic renal cell carcinoma.

Oncoimmunology 2019 2;8(1):e1515611. Epub 2018 Oct 2.

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.

Tumor-infiltrating neutrophils (TINs) show diverse predictive effects in the context of different cancer types and therapeutic regimens. In this study we investigated their relevance with therapeutic effect of tyrosine kinase inhibitors (TKIs) in metastatic renal cell carcinoma (mRCC). Two independent datasets including 271 mRCC patients treated by TKIs or IL-2/IFN-α based immunotherapy were retrospective included, and TINs were detected by immunohistochemistry. Read More

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October 2018
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Predictors of disease aggressiveness influence outcome from immunotherapy treatment in renal clear cell carcinoma.

Oncoimmunology 2019 16;8(1):e1500106. Epub 2018 Oct 16.

Department of Biomedical Data Sciences, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

Renal clear cell carcinoma (RCC) is the most common type of kidney cancer and has a high propensity for metastasis. While treatment with immune checkpoint inhibitors, such as anti-PD-1, have shown modest improvements in survival for RCC, it is difficult to identify responders from non-responders. Attempts to elucidate the mechanisms associated with differential response to checkpoint inhibitors have been limited by small sample size making it difficult to detect meaningful associations. Read More

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October 2018

Energy handling in renal tubular epithelial cells of the hamster, a native hibernator, under warm anoxia or reoxygenation.

Biomed Rep 2018 Dec 12;9(6):503-510. Epub 2018 Oct 12.

Department of Nephrology, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece.

Ischemia-reperfusion (I-R) injury causes several diseases, including acute kidney injury. Hibernating mammals survive periods of torpor with a marked drop in tissue perfusion, interspersed with periods of arousal, and consequently I-R injury. In the present study, sensitivity to anoxia and/or reoxygenation and alterations in cellular ATP and homeostasis of the two most energy consuming processes, protein translation and Na-K-ATPase function, were evaluated in renal proximal tubular epithelial cells of mouse or native hibernator hamster origin. Read More

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December 2018

Anticancer activity of 2'-hydroxyflavanone towards lung cancer.

Oncotarget 2018 Nov 16;9(90):36202-36219. Epub 2018 Nov 16.

Division of Hematology and Oncology, Department of Internal Medicine, Texas Tech Health Sciences Center, Lubbock, TX 79430, USA.

In previous studies, we found that 2'-hydroxyflavonone (2HF), a citrus flavonoid, inhibits the growth of renal cell carcinoma in a VHL-dependent manner. This was associated with the inhibition of glutathione S-transferases (GSTs), the first step enzyme of the mercapturic acid pathway that catalyzes formation of glutathione-electrophile conjugates (GS-E). We studied 2HF in small cell (SCLC) and non-small cell (NSCLC) lung cancer cell lines for sensitivity to 2HF antineoplastic activity and to determine the role of the GS-E transporter Rlip (Ral-interacting protein; RLIP76; RALBP1) in the mechanism of action of 2HF. Read More

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November 2018
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Inhibition of heparanase protects against chronic kidney dysfunction following ischemia/reperfusion injury.

Oncotarget 2018 Nov 16;9(90):36185-36201. Epub 2018 Nov 16.

Renal Unit, Department of Medicine, University Hospital of Verona, Verona, Italy.

Renal ischemia/reperfusion (I/R) injury occurs in patients undergoing renal transplantation and with acute kidney injury and is responsible for the development of chronic allograft dysfunction as characterized by parenchymal alteration and fibrosis. Heparanase (HPSE), an endoglycosidase that regulates EMT and macrophage polarization, is an active player in the biological response triggered by ischemia/reperfusion (I/R) injury. I/R was induced by clamping left renal artery for 30 min in wt C57BL/6J mice. Read More

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November 2018

Human liver stem cell-derived extracellular vesicles enhance cancer stem cell sensitivity to tyrosine kinase inhibitors through Akt/mTOR/PTEN combined modulation.

Oncotarget 2018 Nov 16;9(90):36151-36165. Epub 2018 Nov 16.

Department of Molecular Biotechnology and Health Sciences, Torino, Italy.

It is well recognized that Cancer Stem Cells (CSCs) sustain the initiation, the maintenance and the recurrence of tumors. We previously reported that extracellular vesicles (EVs) derived from human liver stem cells (HLSCs) were able to limit tumor development. In this study, we evaluated whether EV derived from HLSCs could act in synergy with tyrosine kinase inhibitors (TKIs) on apoptosis of CSCs isolated from renal carcinomas. Read More

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November 2018

Preoperative inferior vena cava filter implantation to prevent pulmonary fat embolism in a patient showing renal angiomyolipoma extension into the renal vein: A case report and literature review.

J Rural Med 2018 Nov 29;13(2):181-184. Epub 2018 Nov 29.

Department of Urology, JA Toride Medical Center, Japan.

Renal angiomyolipoma without local invasion is usually considered benign entity, however, it may extend into the renal vein or the inferior vena cava. Renal angiomyolipoma with venous extension should be treated; however, surgical complications such as iatrogenic pulmonary fat embolism remain a serious concern. We present a case of a 66-year-old Japanese woman without tuberous sclerosis in whom a right-sided renal tumor was incidentally detected on ultrasonography during a health check-up. Read More

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November 2018

Neurovascular Coupling Remains Intact During Incremental Ascent to High Altitude (4240 m) in Acclimatized Healthy Volunteers.

Front Physiol 2018 28;9:1691. Epub 2018 Nov 28.

Department of Biology, Mount Royal University, Calgary, AB, Canada.

Neurovascular coupling (NVC) is the temporal link between neuronal metabolic activity and regional cerebral blood flow (CBF), supporting adequate delivery of nutrients. Exposure to high altitude (HA) imposes several stressors, including hypoxia and hypocapnia, which modulate cerebrovascular tone in an antagonistic fashion. Whether these contrasting stressors and subsequent adaptations affect NVC during incremental ascent to HA is unclear. Read More

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November 2018
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Efficacy of First-Line Targeted Therapy in Real-World Korean Patients with Metastatic Renal Cell Carcinoma: Focus on Sunitinib and Pazopanib.

J Korean Med Sci 2018 Dec 22;33(51):e325. Epub 2018 Nov 22.

Department of Urology, National Cancer Center, Goyang, Korea.

Background: To evaluate survival outcomes and prognostic factors for overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC) who received sunitinib (SU) and pazopanib (PZ) as first-line therapy in real-world Korean clinical practice.

Methods: Data of 554 patients with mRCC who received SU or PZ at eight institutions between 2012 and 2016 were retrospectively reviewed. Based on the targeted therapy, the patients were divided into SU (n = 293) or PZ (n = 261) groups, and the clinicopathological variables and survival rates of the two groups were compared. Read More

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December 2018

Adverse Drug Reaction Onsets in Uganda's VigiBase: Delayed International Visibility, Data Quality and Illustrative Signal Detection Analyses.

Pharmaceut Med 2018 17;32(6):413-427. Epub 2018 Nov 17.

3MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.

Introduction: Developing countries can improve their pharmacovigilance systems by analysing their own medication safety data.

Objective: The aims of this study were to characterize Uganda's reported adverse drug reaction (ADR) onsets in 2012-2015 that were registered on VigiBase by 31 December 2017, to document delays in international visibility and the influence of covariates on this delay from ADR onsets in 2013 + 2014, to examine data quality, and to illustrate analytical approaches for safety data, particularly for patients receiving antiretroviral therapy (ART).

Methods: International delay was defined as elapsed time from complete ADR onset date to entry date on VigiBase, with covariates examined using Cox proportional hazards regression. Read More

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November 2018
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Ovarian steroid cell tumor, not otherwise specified.

Pathologica 2018 Sep;110(2):121-122

Department of Pathology and Laboratory Medicine, Medanta-The Medicity, Sector-38, Gurgaon, Haryana 122 001, India.

Ovarian steroid cell tumours are rare virilizing tumours. They are three types of tumours of ovary which are characterized by steroid cell proliferation : Leydig cell tumour, steroid cell tumour, Not Otherwise Specified (NOS) and stromal luteoma. Here we present a case of 36 year old female, who presented with history of weight loss since last two and half months. Read More

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September 2018

Late onset neonatal acute kidney injury: results from the AWAKEN Study.

Pediatr Res 2018 Dec 13. Epub 2018 Dec 13.

Golisano Children's Hospital, University of Rochester, Rochester, NY, USA.

Background: Most studies of neonatal acute kidney injury (AKI) have focused on the first week following birth. Here, we determined the outcomes and risk factors for late AKI (>7d).

Methods: The international AWAKEN study examined AKI in neonates admitted to an intensive care unit. Read More

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December 2018
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Healthcare Resource Use, Cost, and Sick Leave Following Kidney Transplantation in Sweden: A Population-Based, 5-Year, Retrospective Study of Outcomes: COIN.

Ann Transplant 2018 Dec 14;23:852-866. Epub 2018 Dec 14.

Department of Transplantation Surgery, Karolinska University Hospital, Huddinge, Sweden.

BACKGROUND Improved understanding of the impact of kidney transplantation on healthcare resource use/costs and loss of productivity could aid decision making about funding allocation and resources needed for the treatment of chronic kidney disease in stage 5. MATERIAL AND METHODS This was a retrospective study utilizing data from Swedish national health registers of patients undergoing kidney transplantation. Primary outcomes were renal disease-related healthcare resource utilization and costs during the 5 years after transplantation. Read More

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December 2018

Expression Profiling of Fibroblasts in Chronic and Acute Disease Models Reveals Novel Pathways in Kidney Fibrosis.

J Am Soc Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Department of Pathology, University of Michigan, Ann Arbor, Michigan; and

Background: Renal interstitial fibrosis results from activation and proliferation of fibroblasts to myofibroblasts, secretion and accumulation of extracellular matrix, and displacement of normal renal tubules. In contrast to chronic renal disease, acute injury may be repaired, a process that includes a decrease in the number of myofibroblasts in the interstitium and degradation of the accumulated extracellular matrix, leaving little evidence of prior injury.

Methods: To investigate whether activated fibroblasts demonstrate changes in gene expression that correspond with regression after acute injury but are not observed in chronic models of fibrosis, we used microarrays to analyze gene expression patterns among fibroblast populations at different stages of injury or repair. Read More

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December 2018

Influence of Reimbursement Policies on Dialysis Modality Distribution around the World.

Clin J Am Soc Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Imperial College Renal and Transplant Centre, Hammersmith Hospital, London, UK

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December 2018

Hemorrhage from metastasis of a 5-mm renal cell carcinoma lesion to the gallbladder detected by contrast-enhanced endoscopic ultrasonography.

Dig Liver Dis 2018 Nov 22. Epub 2018 Nov 22.

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.

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November 2018

Use of Measures of Inflammation and Kidney Function for Prediction of Atherosclerotic Vascular Disease Events and Death in Patients With CKD: Findings From the CRIC Study.

Am J Kidney Dis 2018 Dec 10. Epub 2018 Dec 10.

Division of Kidney Diseases and Hypertension, George Washington University, Washington, DC. Electronic address:

Rationale & Objective: Traditional risk estimates for atherosclerotic vascular disease (ASVD) and death may not perform optimally in the setting of chronic kidney disease (CKD). We sought to determine whether the addition of measures of inflammation and kidney function to traditional estimation tools improves prediction of these events in a diverse cohort of patients with CKD.

Study Design: Observational cohort study. Read More

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December 2018

Exploring Barriers and Potential Solutions in Home Dialysis: An NKF-KDOQI Conference Outcomes Report.

Am J Kidney Dis 2018 Dec 10. Epub 2018 Dec 10.

Wake Forest School of Medicine, Winston-Salem, NC. Electronic address:

Home dialysis therapy, including home hemodialysis and peritoneal dialysis, is underused as a modality for the treatment of chronic kidney failure. The National Kidney Foundation-Kidney Disease Outcomes Quality Initiative sponsored a home dialysis conference in late 2017 that was designed to identify the barriers to starting and maintaining patients on home dialysis therapy. Clinical, operational, policy, and societal barriers were identified that need to be overcome to ensure that dialysis patients have the freedom to choose their treatment modality. Read More

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December 2018

Cost-Effectiveness of Second-Line Treatments for Metastatic Renal-Cell Carcinoma.

Clin Genitourin Cancer 2018 Nov 22. Epub 2018 Nov 22.

Department of Oncology, Mater Salutis Hospital, Legnago, Italy.

Purpose: To assess the pharmacologic costs of second-line treatments for metastatic renal-cell cancer (mRCC).

Methods: The present evaluation was restricted to pivotal phase 3 randomized controlled trials in second-line for mRCC. We calculated the pharmacologic costs necessary to get the benefit in progression-free survival and overall survival (OS) for each trial. Read More

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November 2018

Autophagy in FOXD1 stroma-derived cells regulates renal fibrosis through TGF-β and NLRP3 inflammasome pathway.

Biochem Biophys Res Commun 2018 Dec 10. Epub 2018 Dec 10.

Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea. Electronic address:

Renal fibrosis is the final common pathway of various renal injuries and it leads to chronic kidney disease. Recent studies reported that FOXD1-lineage pericyte plays a critical role in tubulointerstitial fibrosis (TIF). However the regulatory mechanisms remain unclear. Read More

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December 2018

Epidermal growth factor receptor and podocin predict nephropathy progression in type 2 diabetic patients through interaction with the autophagy influencer ULK-1.

J Diabetes Complications 2018 Nov 22. Epub 2018 Nov 22.

Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address:

Aims: Diabetic nephropathy (DN) that progress to end stage renal failure is a serious health problem. Autophagy is involved in DN pathogenesis. Finding renal prognostic biomarkers can help in the future renal status prevision. Read More

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November 2018

Double collecting system with ectopic ureterocele masquerading as an ovarian torsion.

Taiwan J Obstet Gynecol 2018 Dec;57(6):867-870

Department of Obstetrics and Gynecology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Obstetrics and Gynecology, Hsin-Chu Br, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

Objective: Ureterocele in a duplex system is rare and commonly presented with urinary tract infection at neonatal age, infant or childhood. Symptomatic ureterocele in reproductive-age is a diagnostic challenge and should be highly awarded to avoid miss-diagnosis.

Case Report: An adolescent girl with right ectopic ureterocele presented as acute abdomen that mimicked ovarian torsion received emergent laparoscopic surgery. Read More

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December 2018

Image-Guided Nephrostomy Interventions: How to Recognize, Avoid, or Get Out of Trouble.

Tech Vasc Interv Radiol 2018 Dec 30;21(4):261-266. Epub 2018 Jul 30.

Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC.

Image-guided percutaneous nephrostomy is a relatively safe and successful procedure for access to the renal collecting system for multiple purposes including relief of urinary obstruction, urinary diversion, access for endourologic procedures, and diagnostic testing. Although placing a percutaneous nephrostomy catheter is most times straightforward, providing immediate benefit for the patient and satisfaction for the practitioner, there can be situations that make the procedure more difficult or risky. A thorough review of the patient's imaging and medical record will help to set a path for success. Read More

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December 2018
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Interventional Oncology: Keeping Out of Trouble in Ablation Techniques.

Tech Vasc Interv Radiol 2018 Dec 14;21(4):223-227. Epub 2018 Aug 14.

Department of Interventional Radiology, New York Presbyterian Hospital/Weill Cornell Medicine, New York, NY. Electronic address:

Interventional radiologists provide an essential role in the therapy and management of cancer patients. Computed-tomography (CT) guided percutaneous procedures have enabled interventionalists to treat multiple solid organ malignancies with minimal risk, however, certain lesions may present challenges to physicians due to a difficult approach, or their close proximity to other vital structures. The following presents a brief summary of tips and tricks the interventionalist may use to provide their patients with safe and effective therapy. Read More

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December 2018

Symtuza in clinical practice.

Enferm Infecc Microbiol Clin 2018 Dec;36 Suppl 2:31-36

Departamento de Enfermedades Infecciosas, Hospital Ramón y Cajal, Madrid.

Because lifelong therapy is needed in HIV infection, high long-term adherence is necessary. Darunavir/co-bicistat/emtricitabina/tenofovir alafenamide (Symtuza) is the first triple therapy combining a protease inhibitor (PI) in a single tablet regimen. This drug combines the potency and high genetic barrier of the most effective PI, darunavir, with the renal and bone safety of tenofovir alafenamide. Read More

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December 2018

Pharmacology of Symtuza (DRV/c/FTC/TAF).

Enferm Infecc Microbiol Clin 2018 Dec;36 Suppl 2:10-16

Servicio de Enfermedades Infecciosas, Hospital Universitari Vall d'Hebron, Barcelona; Vall d'Hebron Institut de Recerca, Barcelona.

Symtuza is the first and only treatment for HIV-1 that combines 2 nucleos(t)ide analogues (emtricitabine and tenofovir alafenamide) together with a boosted protease inhibitor (darunavir/cobicistat) in a once-daily single tablet regimen (STR). This combination is active against a wide variety of HIV strains and, in turn, avoids bone and renal toxicity associated with the use of tenofovir disoproxil fumarate, combining efficacy, convenience, tolerability and high genetic barrier. Pharmacokinetic studies of its components show a favourable profile, allowing its use in a wide variety of patients and clinical situations. Read More

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December 2018

Factors associated with acute kidney injury in the Helsinki Burn Centre in 2006-2015.

Scand J Trauma Resusc Emerg Med 2018 Dec 13;26(1):105. Epub 2018 Dec 13.

Helsinki Burn Centre, Department of Plastic Surgery, Helsinki University Hospital and University of Helsinki, PO. Box 800, FI-00029 HUS, Helsinki, Finland.

Background: Acute kidney injury (AKI) is a common complication in severe burns and can lead to significantly poorer outcomes. Although the prognosis has improved in recent decades, the mortality of AKI remains considerable. We investigated the factors that increase the risk of AKI and death after severe burn injury. Read More

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December 2018

In vitro removal of anti-infective agents by a novel cytokine adsorbent system.

Int J Artif Organs 2018 Dec 13:391398818812601. Epub 2018 Dec 13.

1 Department of Intensive Care Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Objectives:: The aim of this study is to describe the in vitro adsorption of anti-infective drugs onto an extracorporeal cytokine adsorber.

Methods:: Various anti-infective drugs (β-lactams, quinolones, aminoglycosides, glycopeptides, azole antimycotics) were prepared in normal saline 0.9% and human albumin 5%, and pumped through a cytokine cartridge (CytoSorb; CytoSorbents Corporation, Monmouth Junction, NJ, USA) at a flow rate of 1. Read More

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December 2018

Dia-gnostic Challenges and Extraordinary Treatment Response in Rare Malignant PEComa Tumor of the Kidney.

Klin Onkol 2018 ;31(6):448-452

Background: Epithelioid angiomyolipoma (EAML) of the kidney, in contrast to classic benign renal angiomyolipoma, is a rare mesenchymal neoplasm with malignant potential. Represent-ing a member of the perivascular epithelioid cells (PEComa) tumor family aris-ing from the perivascular epithelioid cells, its accurate dia-gnosis and therapeutic approach remains challenging.

Methods: We report a case of a patient with malignant EAML, initially treated as renal cell carcinoma (RCC) at our institution. Read More

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January 2018

Acute Toxicity of the Recombinant and Native Phα1β Toxin: New Analgesic from Spider Venom.

Toxins (Basel) 2018 Dec 12;10(12). Epub 2018 Dec 12.

Postgraduate Program in Genetics and Applied Toxicology, Lutheran University of Brazil, Canoas, RS 92425⁻900, Brazil.

Phα1β, a purified peptide from the venom of the spider , and its recombinant form CTK 01512-2 are voltage-dependent calcium channel (Ca) blockers of types N, R, /Q, and L with a preference for type N. These peptides show analgesic action in different pain models in rats. The aim of this study was to evaluate the acute intrathecal toxicity of the native and recombinant Phα1β toxin in Wistar rats. Read More

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December 2018
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The Stress-Inducible Protein DRR1 Exerts Distinct Effects on Actin Dynamics.

Int J Mol Sci 2018 Dec 11;19(12). Epub 2018 Dec 11.

Max Planck Institute of Psychiatry, Kraepelinstraße 2-10, 80805 München, Germany.

Cytoskeletal dynamics are pivotal to memory, learning, and stress physiology, and thus psychiatric diseases. Downregulated in renal cell carcinoma 1 (DRR1) protein was characterized as the link between stress, actin dynamics, neuronal function, and cognition. To elucidate the underlying molecular mechanisms, we undertook a domain analysis of DRR1 and probed the effects on actin binding, polymerization, and bundling, as well as on actin-dependent cellular processes. Read More

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December 2018

Eosinophilia and Kidney Disease: More than Just an Incidental Finding?

J Clin Med 2018 Dec 8;7(12). Epub 2018 Dec 8.

Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, 6020 Innsbruck, Austria.

Peripheral blood eosinophilia (PBE), defined as 500 eosinophils or above per microliter (µL) blood, is a condition that is not uncommon but often neglected in the management of patients with chronic kidney disease (CKD), acute kidney injury (AKI), or patients on renal replacement therapy (RRT). The nature of PBE in the context of kidney diseases is predominantly secondary or reactive and has to be distinguished from primary eosinophilic disorders. Nonetheless, the finding of persistent PBE can be a useful clue for the differential diagnosis of underdiagnosed entities and overlapping syndromes, such as eosinophilic granulomatosis with polyangiitis (EGPA), IgG4-related disease (IgG4-RD), acute interstitial nephritis (AIN), or the hypereosinophilic syndrome (HES). Read More

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December 2018

Surface Charge-Dependent Cellular Uptake of Polystyrene Nanoparticles.

Nanomaterials (Basel) 2018 Dec 10;8(12). Epub 2018 Dec 10.

Lab of Toxicology, Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan 49315, Korea.

The evaluation of the role of physicochemical properties in the toxicity of nanoparticles is important for the understanding of toxicity mechanisms and for controlling the behavior of nanoparticles. The surface charge of nanoparticles is suggested as one of the key parameters which decide their biological impact. In this study, we synthesized fluorophore-conjugated polystyrene nanoparticles (-PLNPs), with seven different types of surface functional groups that were all based on an identical core, to evaluate the role of surface charge in the cellular uptake of nanoparticles. Read More

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December 2018

Prevalence and Correlates of Sarcopenia among Elderly CKD Outpatients on Tertiary Care.

Nutrients 2018 Dec 10;10(12). Epub 2018 Dec 10.

Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.

Background: Sarcopenia is a widespread concern in chronic kidney disease (CKD) as well in elderly patients and is one of the main reasons why low-protein diets for this population are controversial. The aim of this study was to assess the prevalence and correlates of sarcopenia among elderly male patients affected by CKD followed up in an outpatient nephrology clinic, where moderate protein restriction (0.6⁻0. Read More

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December 2018

Anticancer Action and Mechanism of Ergosterol Peroxide from Fermentation Broth.

Int J Mol Sci 2018 Dec 7;19(12). Epub 2018 Dec 7.

School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China.

, a medicinal food fungus, is a fruit from . In this study, we purified ergosterol peroxide (EP) from the fermentation broth of and investigated its effects on renal cell carcinoma (RCC) cells, in vitro. EP was purified from fermentation broth. Read More

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December 2018

Predictive Value of Cortical Thickness Measured by Ultrasonography for Renal Impairment: A Longitudinal Study in Chronic Kidney Disease.

J Clin Med 2018 Dec 7;7(12). Epub 2018 Dec 7.

Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8504, Japan.

Background: Kidney size is associated with renal function, however it is not elucidated whether kidney size is a risk for the progression of chronic kidney disease. The aim of this study was to investigate the predictive value of morphological evaluation of kidney size by ultrasonography for the progression of renal dysfunction.

Methods: Morphological parameters including kidney length, volume, cortical thickness, and medullary thickness were measured by ultrasonography in 87 patients with chronic kidney disease, and adjusted by body size. Read More

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December 2018

Egg Intake in Chronic Kidney Disease.

Nutrients 2018 Dec 7;10(12). Epub 2018 Dec 7.

Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202, USA.

Patients with chronic kidney disease (CKD) are often instructed to adhere to a renal-specific diet depending on the severity and stage of their kidney disease. The prescribed diet may limit certain nutrients, such as phosphorus and potassium, or encourage the consumption of others, such as high biological value (HBV) proteins. Eggs are an inexpensive, easily available and high-quality source of protein, as well as a rich source of leucine, an essential amino acid that plays a role in muscle protein synthesis. Read More

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December 2018
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