148,950 results match your criteria Relaxed Vaginal Outlet


Vascular and metabolic profiles in offspring born to pregnant mice with metabolic syndrome treated with inositols.

Am J Obstet Gynecol 2018 Dec 3. Epub 2018 Dec 3.

Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Health Science Center at Houston, Houston, Texas.

Background: Inositols (INOs) supplementation during pregnancy, specifically the combination of myo-inositol (MI) and D-chiro-inositol (DCI), has been reported to improve vascular parameters in women with gestational diabetes mellitus. We demonstrated previously that offspring born to pregnant mice lacking endothelial nitric oxide synthase (eNOS+/-) gene have hypertension (HTN) as adults and when fed high fat diet (HFD) develop a metabolic syndrome (MS) phenotype.

Objective: Our aim was to evaluate if INOs treatment in pregnancy complicated by MS improves the vascular and metabolic profile in mice offspring programmed in utero to develop HTN and MS. Read More

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December 2018

Controlling the Activity and Stability of Electrochemical Interfaces Using Atom-by-Atom Metal Substitution of Redox Species.

ACS Nano 2018 Dec 6. Epub 2018 Dec 6.

Understanding the molecular-level properties of electrochemically-active ions at operating electrode-electrolyte interfaces (EEI) is key to the rational development of high-performance nanostructured surfaces for applications in energy technology. Herein, an electrochemical cell coupled with ion soft landing is employed to examine the effect of "atom-by-atom" metal substitution on the activity and stability of well-defined redox-active anions, PMoWO (x = 0,1,2,3,6,9,12), at nanostructured ionic liquid EEI. A striking observation made by in situ electrochemical measurements and further supported by theoretical calculations is that substitution of only (1-3) tungsten by molybdenum atoms in the PWO anions results in a substantial spike in their first reduction potential. Read More

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December 2018
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Controlling the dominant magnetic relaxation mechanisms for magnetic hyperthermia in bimagnetic core-shell nanoparticles.

Nanoscale 2018 Dec 6. Epub 2018 Dec 6.

Instituto de Nanociencia y Nanotecnología, CNEA, CONICET, Centro Atómico Bariloche, Av. Bustillo 9500 (8400) S. C. Bariloche, Argentina.

We report a simple and effective way to control the heat generation of a magnetic colloid under alternate magnetic fields by changing the shell composition of bimagnetic core-shell Fe3O4/ZnxCo1-xFe2O4 nanoparticles. The core-shell structure constitutes a magnetically-coupled biphase system, with an effective anisotropy that can be tuned by the substitution of Co2+ by Zn2+ ions in the shell. Magnetic hyperthermia experiments of nanoparticles dispersed in hexane and butter oil showed that the magnetic relaxation is dominated by Brown relaxation mechanism in samples with higher anisotropy (i. Read More

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December 2018

Perinatal changes in fetal cardiac geometry and function in gestational diabetic pregnancies at term.

Ultrasound Obstet Gynecol 2018 Dec 6. Epub 2018 Dec 6.

Molecular & Clinical Sciences Research Institute, St George's University of London.

Objective: To evaluate the effect of gestational diabetes mellitus (GDM) on fetal and neonatal cardiac geometry and function around the time of birth.

Methods: A prospective study of 75 pregnant women delivering at term, comprising of 54 normal pregnancies and 21 with a diagnosis GDM. Fetal and neonatal conventional cardiac indices, spectral tissue Doppler and 2D speckle tracking imaging were performed a few days before and within hours of birth. Read More

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December 2018
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Improvements in Lipid Suppression for 1H NMR-based Metabolomics: Applications to Solution-state and HR-MAS NMR-natural and in vivo samples.

Magn Reson Chem 2018 Dec 5. Epub 2018 Dec 5.

Environmental NMR Centre, Dept. of Physical and Environmental Sciences, University of Toronto, Scarborough, 1265 Military Trail, Toronto, ON, Canada, M1C 1A4.

Proton NMR spectra of intact biological samples often show strong contributions from lipids which overlap with signals of interest from small metabolites. Pioneering work by Diserens et al. demonstrated that the relative differences in diffusivity and relaxation of lipids verses small metabolites could be exploited to suppress lipid signals, in HR-MAS NMR spectroscopy. Read More

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December 2018
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Comparison of native myocardial T1 and T2 mapping at 1.5T and 3T in healthy volunteers : Reference values and clinical implications.

Wien Klin Wochenschr 2018 Dec 5. Epub 2018 Dec 5.

Department of Radiology, Paracelsus Medical University, Müllner Hauptstraße 48, 5020, Salzburg, Austria.

Background: Myocardial native T1 and T2 mapping are promising techniques for quantitative assessment of diffuse myocardial pathologies; however, due to conflicting data regarding normal values, routine clinical implementation of this method is still challenging.

Methods: To evaluate this situation during daily clinical practice the characteristics of normal values obtained in 60 healthy volunteers who underwent magnetic resonance imaging (MRI) scans on 1.5T and 3T scanners were studied. Read More

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December 2018
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A comparison of biological activity of commercially available purified native botulinum neurotoxin serotypes A1 to F1 in vitro, ex vivo, and in vivo.

Pharmacol Res Perspect 2018 Dec 22;6(6):e00446. Epub 2018 Nov 22.

Ipsen Bioinnovation Abingdon Oxford UK.

Botulinum neurotoxin (BoNT) is a major therapeutic agent. Of seven native BoNT serotypes (A to G), only A and B are currently used in the clinic. Here we compared the potency of commercially available purified native serotypes A1 to F1 across in vitro, ex vivo, and in vivo assays. Read More

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December 2018

Inter-Vendor Reproducibility of Myelin Water Imaging Using a 3D Gradient and Spin Echo Sequence.

Front Neurosci 2018 21;12:854. Epub 2018 Nov 21.

Department of Medicine, The University of British Columbia, Vancouver, BC, Canada.

Myelin water imaging can be achieved using multicomponent T relaxation analysis to quantify measurement of myelin content, termed the myelin water fraction (MWF). Therefore, myelin water imaging can be a valuable tool to better understand the underlying white matter pathology in demyelinating diseases, such as multiple sclerosis. To apply myelin water imaging in multisite studies and clinical applications, it must be acquired in a clinically feasible scan time (less than 15 min) and be reproducible across sites and scanner vendors. Read More

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November 2018
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Clinical efficacy of transcutaneous triamcinolone acetonide injection for upper eyelid retraction and swelling in patients with thyroid eye disease.

Int Med Case Rep J 2018 9;11:325-331. Epub 2018 Nov 9.

Olympia Eye Hospital, Tokyo, Japan,

Aim: To evaluate the efficacy of transcutaneous triamcinolone acetonide (TA) injection for the treatment of upper eyelid retraction and swelling in thyroid eye disease (TED) patients.

Patients And Methods: This is a case series. Three euthyroid TED patients with features of both upper eyelid retraction and swelling were recruited. Read More

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November 2018

Wavepacket insights into the photoprotection mechanism of the UV filter methyl anthranilate.

Nat Commun 2018 Dec 5;9(1):5188. Epub 2018 Dec 5.

Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.

Meradimate is a broad-spectrum ultraviolet absorber used as a chemical filter in commercial sunscreens. Herein, we explore the ultrafast photodynamics occurring in methyl anthranilate (precursor to Meradimate) immediately after photoexcitation with ultraviolet radiation to understand the mechanisms underpinning Meradimate photoprotection. Using time-resolved photoelectron spectroscopy, signal from the first singlet excited state of methyl anthranilate shows an oscillatory behavior, i. Read More

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December 2018

Voxel-based automatic multi-criteria optimization for intensity modulated radiation therapy.

Radiat Oncol 2018 Dec 5;13(1):241. Epub 2018 Dec 5.

Department of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, Guangdong, China.

Background: Automatic multi-criteria optimization is necessary for intensity modulated radiation therapy (IMRT) because of low planning efficiency and large plan quality uncertainty in current clinical practice. Most studies focused on imitating dosimetrists' planning procedures to automate this process and ignored the fact that organ-based objective functions typically used in commercial treatment planning systems (such as dose-volume function) usually lead to sub-optimal plans. To guarantee the optimum results and to automate this process, we incorporate an improved automation strategy and a voxel-based optimization algorithm to generate a novel automatic multi-criteria optimization framework. Read More

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December 2018

Shot Down Inflamed: Airway Smooth Muscle Bronchodilator Insensitivity in Cystic Fibrosis.

Am J Respir Cell Mol Biol 2018 Dec 3. Epub 2018 Dec 3.

University of Manitoba, Section of Respiratory Diseases, Winnipeg, Manitoba, Canada ;

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December 2018

Chain organization of human interphase chromosome determines the spatiotemporal dynamics of chromatin loci.

PLoS Comput Biol 2018 Dec 3;14(12):e1006617. Epub 2018 Dec 3.

Korea Institute for Advanced Study, Seoul, Korea.

We investigate spatiotemporal dynamics of human interphase chromosomes by employing a heteropolymer model that incorporates the information of human chromosomes inferred from Hi-C data. Despite considerable heterogeneities in the chromosome structures generated from our model, chromatins are organized into crumpled globules with space-filling (SF) statistics characterized by a single universal scaling exponent (ν = 1/3), and this exponent alone can offer a quantitative account of experimentally observed, many different features of chromosome dynamics. The local chromosome structures, whose scale corresponds to that of topologically associated domains (∼ 0. Read More

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December 2018

Study on the Therapeutic Effects of Trigeminal Neuralgia With Microvascular Decompression and Stereotactic Gamma Knife Surgery in the Elderly.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Neurosurgery, The Second Hospital of Shandong University, Jinan, China.

Objective: The aim of the study was to evaluate the efficacy of microvascular decompression (MVD) and stereotactic gamma knife surgery (GKS) in the treatment of trigeminal neuralgia (TN) in the elderly.

Patients And Methods: Retrospective analysis of 137 elderly cases with TN underwent MVD, partial sensory rhizotomy (PR) treatment from August 2007 to March 2017 and 56 cases underwent GKS treatment from May 2014 to February 2017 was made, compared the efficacy of MVD and GKS in different age groups.

Results: In 125 patients of MVD alone, the responsible vessels included 60 cases of superior cerebellar artery, 55 cases of anterior inferior cerebellar artery, 4 cases of venous vascular compression, 13 cases of mixed arteriovenous compression and 3 cases of vertebral artery, and 2 cases of no responsible vessel. Read More

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November 2018

Effects of Underrunning Water Bathing and Immersion Tub Bathing on Vital Signs of Newborn Infants: A Comparative Analysis.

Adv Neonatal Care 2018 Dec;18(6):E3-E12

Pediatric Nursing Department, Florence Nightingale Faculty of Nursing, Istanbul University, Şişli, Turkey.

Background: Newborn infants are susceptible to hypothermia during bathing due to environmental conditions.

Purpose: This study examined the effects of 2 common newborn bathing methods used in Turkey, underrunning water bathing (URWB) and immersion tub bathing (ITB), on infant heart rate (HR), oxygen saturation, and body temperature.

Methods: In this randomized controlled study, 44 newborns were allocated to the ITB group and 36 newborns to the URWB group. Read More

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December 2018

Measurement and Nonpharmacologic Management of Sleep Disturbance in the Intensive Care Units: A Literature Review.

Crit Care Nurs Q 2019 Jan/Mar;42(1):75-80

Princess Aisha Bint Al-Hussein College of Nursing & Health Sciences, Al-Hussein Bin Talal University, Maan, Jordan (Dr Bani Younis); Faculty of Nursing, University of Jordan, Amman, Jordan (Dr Hayajneh); and Philadelphia University, Amman, Jordan (Dr Batiha).

The general goal of this review is to summarize, clarify, and evaluate what is known about patients' sleep in the intensive care units (ICUs) in terms of sleep measurement and management. In addition, this review focuses on the gap in knowledge in this field. A review of online databases for relevant articles in the period between 2000 and 2017 was conducted. Read More

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December 2018

Unconstrained Estimation of HRV Indices after Removing Respiratory Influences from Heart Rate.

IEEE J Biomed Health Inform 2018 Dec 3. Epub 2018 Dec 3.

Objective: This paper proposes an approach to better estimate the sympathovagal balance (SB) and the respiratory sinus arrhythmia (RSA) after separating respiratory influences from the heart rate (HR).

Methods: The separation is performed using orthogonal subspace projections and the approach is first tested using simulated HR and respiratory signals with different spectral properties. Then, RSA and SB are estimated during autonomic blockade and stress using the proposed approach and the classical heart rate variability (HRV) analysis. Read More

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December 2018

Molecular Dynamics Study of the Effect of Water on Hydrophilic and Hydrophobic Ionic Liquids.

Authors:
Takahiro Koishi

J Phys Chem B 2018 Dec 3. Epub 2018 Dec 3.

We performed molecular dynamics (MD) simulations of ionic liquid (IL)-water mixtures to investigate the effects of water addition. The IL cation 1-butyl-3-methylimidazolium ([C4mim]) and the four anions, nitrate (NO3), tetrafluoroborate (BF4), hexafluorophosphate (PF6), and bis(trifluoromethanesulfonyl)imide (NTf2), are used to examine the effects of differences in hydrophobicity and anion size. The radial distribution functions of water-water have two different water content dependences. Read More

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December 2018

Supercooling and Nucleation of Fatty Acids: Influence of Thermal History on the Behavior of the Liquid Phase.

J Phys Chem B 2018 Dec 3. Epub 2018 Dec 3.

Saturated fatty acids are an exceptionally important class of liquids, used in many consumer products and suggested as phase change materials (PCMs) for thermal energy storage, in part because they crystallize with minimal supercooling. Here we investigate fatty acid nucleation to understand why crystallization is so facile, as a step toward identifying potential mechanisms for the suppression of supercooling in other PCMs. We find that fatty acid supercooling can be induced only if the liquid is first heated above a material-dependent threshold temperature. Read More

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December 2018

Excited State Vibrational Spectra of All-Trans Retinal Derivatives in Solution Revealed by Pump-DFWM Experiments.

J Phys Chem B 2018 Dec 3. Epub 2018 Dec 3.

The ultrafast structural changes during the photo-induced isomerization of Retinal protonated Schiff base (RPSB) is still a poorly understood aspect in the Retinal's photochemistry. In this work, we apply pump-degenerate four-wave mixing (pump-DFWM) to all-trans retinal (ATR) and retinal Schiff bases (RSB) to resolve coherent high- and low-frequency vibrational signatures from excited electronic states. We show that the vibrational spectra of excited singlet states in these samples exhibit pronounced differences compared to the relaxed ground state. Read More

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December 2018

Measuring intra-axonal T in white matter with direction-averaged diffusion MRI.

Magn Reson Med 2018 Dec 2. Epub 2018 Dec 2.

Center for Biomedical Imaging, Medical University of South Carolina, Charleston, South Carolina.

Purpose: To demonstrate how the T relaxation time of intra-axonal water (T ) in white matter can be measured with direction-averaged diffusion MRI.

Methods: For b-values larger than about 4000 s/mm , the direction-averaged diffusion MRI signal from white matter is dominated by the contribution from water within axons, which enables T to be estimated by acquiring data for multiple TE values and fitting a mono-exponential decay curve. If given a value of the intra-axonal diffusivity, an extension of the method allows the extra-axonal relaxation time (T ) to be calculated also. Read More

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December 2018

The choice of embedding media affects image quality, tissue R , and susceptibility behaviors in post-mortem brain MR microscopy at 7.0T.

Magn Reson Med 2018 Dec 2. Epub 2018 Dec 2.

NeuroCure Clinical Research Center, Charité-Universitaetsmedizin, Berlin, Germany.

Purpose: The quality and precision of post-mortem MRI microscopy may vary depending on the embedding medium used. To investigate this, our study evaluated the impact of 5 widely used media on: (1) image quality, (2) contrast of high spatial resolution gradient-echo (T and T -weighted) MR images, (3) effective transverse relaxation rate (R ), and (4) quantitative susceptibility measurements (QSM) of post-mortem brain specimens.

Methods: Five formaldehyde-fixed brain slices were scanned using 7. Read More

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December 2018
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Behavioral Therapies and Mind-Body Interventions for Posttraumatic Headache and Post-Concussive Symptoms: A Systematic Review.

Headache 2018 Dec 1. Epub 2018 Dec 1.

NYU College of Nursing, New York, NY, USA.

Background: There are no clear guidelines on how to treat posttraumatic headache (PTH) or post-concussive symptoms (PCS). However, behavioral interventions such as cognitive behavioral therapy, biofeedback, and relaxation are Level-A evidence-based treatments for headache prevention. To understand how to develop and study further mind-body interventions (MBIs) and behavioral therapies for PTH and PCS, we developed the following question using the PICO framework: Are behavioral therapies and MBIs effective for treating PTH and PCS?

Methods: We conducted a systematic search of 3 databases (Medline, PsycINFO, and EMBASE) for behavioral interventions and MBIs with the subject headings and keywords for PTH, concussion, and traumatic brain injury (TBI). Read More

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December 2018

Determination of in vitro absorption in Caco-2 monolayers of anticancer Ru(II)-based complexes acting as dual human topoisomerase and PARP inhibitors.

Biometals 2018 Nov 30. Epub 2018 Nov 30.

Center of Exact Sciences and Technology, Federal University of São Carlos, São Carlos, SP, 13565-905, Brazil.

Due to their unique and versatile biochemical properties, ruthenium-based compounds have emerged as promising anticancer agents. Previous studies showed that three ruthenium(II) compounds: [Ru(pySH)(bipy)(dppb)]PF (1), [Ru(HSpym)(bipy)(dppb)]PF (2) and Ru[(SpymMe)(bipy)(dppb)]PF (3) presented anticancer properties higher than doxorubicin and cisplatin and acted as human topoisomerase IB (Topo I) inhibitors. Here, we focused our studies on in vitro intestinal permeability and anticancer mechanisms of these three complexes. Read More

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November 2018

Short-term changes observed in multiparametric liver MRI following therapy with direct-acting antivirals in chronic hepatitis C virus patients.

Eur Radiol 2018 Nov 30. Epub 2018 Nov 30.

Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK.

Methods: We applied multiparametric MRI to assess changes in liver composition, perfusion and blood flow in 17 patients before direct-acting antiviral (DAA) therapy and after treatment completion (within 12 weeks of last DAA tablet swallowed).

Results: We observed changes in hepatic composition indicated by a reduction in both liver longitudinal relaxation time (T1, 35 ± 4 ms), transverse relaxation time (T2, 2.5 ± 0. Read More

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November 2018

Force field development phase II: Relaxation of physics-based criteria… or inclusion of more rigorous physics into the representation of molecular energetics.

Authors:
A T Hagler

J Comput Aided Mol Des 2018 Nov 30. Epub 2018 Nov 30.

Department of Chemistry, University of Massachusetts, Amherst, MA, 01003, USA.

In the previous paper, we reviewed the origins of energy based calculations, and the early science of FF development. The initial efforts spanning the period from roughly the early 1970s to the mid to late 1990s saw the development of methodologies and philosophies of the derivation of FFs. The use of Cartesian coordinates, derivation of the H-bond potential, different functional forms including diagonal quadratic expressions, coupled valence FFs, functional form of combination rules, and out of plane angles, were all investigated in this period. Read More

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November 2018

Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells.

Acta Pharm Sin B 2018 Oct 26;8(6):909-918. Epub 2018 Jul 26.

Department of Pharmacology (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150086, China.

Our previous studies found that mitochondrial uncouplers CCCP and niclosamide inhibited artery constriction and the mechanism involved AMPK activation in vascular smooth muscle cells. BAM15 is a novel type of mitochondrial uncoupler. The aim of the present study is to identify the vasoactivity of BAM15 and characterize the BAM15-induced AMPK activation in vascular smooth muscle cells (A10 cells). Read More

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October 2018
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Can a stress management programme reduce stress and improve quality of life in people diagnosed with multiple sclerosis?

Mult Scler J Exp Transl Clin 2018 Oct-Dec;4(4):2055217318813179. Epub 2018 Nov 26.

Department of Neurology, John Hunter Hospital, Australia.

Background: Despite evidence of perceived stress as a risk factor for multiple sclerosis activity, the evidence for managing stress is limited.Objective To evaluate a stress management programme on perceived stress and quality of life, over 6 months.

Methods: One hundred people with multiple sclerosis were randomly assigned to either a stress management programme of mindfulness, meditation and progressive muscle relaxation, or wait list. Read More

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November 2018

Entangled polymer dynamics beyond reptation.

Nat Commun 2018 Nov 30;9(1):5098. Epub 2018 Nov 30.

Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.

Macroscopic properties of polymers arise from microscopic entanglement of polymer chains. Entangled polymer dynamics have been described theoretically by time- and space-averaged relaxation modes of single chains occurring at different time and length scales. However, theoretical and experimental studies along this framework provide oversimplified picture of spatiotemporally heterogeneous polymer dynamics. Read More

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November 2018

Analysis of NMR Spin-Relaxation Data Using an Inverse Gaussian Distribution Function.

Biophys J 2018 Nov 6. Epub 2018 Nov 6.

Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York. Electronic address:

Spin relaxation in solution-state NMR spectroscopy is a powerful approach to explore the conformational dynamics of biological macromolecules. Probability distribution functions for overall or internal correlation times have been used previously to model spectral density functions central to spin-relaxation theory. Applications to biological macromolecules rely on transverse relaxation rate constants, and when studying nanosecond timescale motions, sampling at ultralow frequencies is often necessary. Read More

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November 2018

Tolerating Subretinal Fluid in Neovascular Age-Related Macular Degeneration Treated With Ranibizumab Using a Treat and Extend Regimen: FLUID Study 24 Month Results.

Ophthalmology 2018 Nov 28. Epub 2018 Nov 28.

Marsden Eye Specialists, 152 Marsden Rd, Parramatta NSW, Australia.

Purpose: To test the hypothesis that tolerating some subretinal fluid (SRF) in patients with neovascular age-related macular degeneration (nAMD) treated with ranibizumab using a treat-and-extend (T&E) regimen can achieve similar visual acuity (VA) outcomes as treatment aimed at resolving all SRF.

Design: Multi-center, randomized, 24-month, phase IV, single-masked, non-inferiority clinical trial.

Subjects: Subjects presenting with treatment-naive nAMD. Read More

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November 2018

Geometric, elastic and contractile-relaxation changes in coronary arterioles induced by Vitamin D deficiency in normal and hyperandrogenic female rats.

Microvasc Res 2018 Nov 28;122:78-84. Epub 2018 Nov 28.

2nd Department of Obstetrics and Gynecology, Semmelweis University, Faculty of Medicine, Budapest, Hungary.

Vitamin D (VitD) hypovitaminosis and androgen excess (AE) are both risk factors for cardiovascular diseases in fertile women. However, the possible early interaction between AE and VitD status is not clear. Our goal was to describe how VitD status influences early changes in the biomechanical reactivity of small coronary arterioles in adult female rats after transdermal testosterone treatment. Read More

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November 2018

Hyperglycemia-impaired aortic vasorelaxation mediated through arginase elevation: Role of stress kinase pathways.

Eur J Pharmacol 2018 Nov 28. Epub 2018 Nov 28.

Department of Pharmacology and Toxicology, Augusta University, Augusta, GA, USA; Vascular Biology Center, Augusta University, Augusta, GA, USA.

Diabetes-induced vascular endothelial dysfunction has been reported to involve hyperglycemia-induced increases in arginase activity. However, upstream mediators of this effect are not clear. Here, we have tested involvement of Rho kinase, ERK1/2 and p38 MAPK pathways in this process. Read More

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November 2018

Improvement of color, texture and food safety of ready-to-eat high pressure-heat treated duck breast.

Food Chem 2019 Mar 3;277:646-654. Epub 2018 Nov 3.

Key Laboratory of Meat Processing & Quality Control, Ministry of Education, Key Laboratory of Animal Products Processing, Ministry of Agriculture, College of Food Science & Technology, Nanjing Agricultural University, Nanjing 210095, PR China. Electronic address:

Since high-temperature cooking (>95 °C) deteriorates duck meat quality, a lower temperature (70 °C) with high-pressure (400 MPa) were investigated. Duck breast was subjected to salting/pickling treatment prior to heating-alone (70 °C) or HPP with heating (P + H) for 10 or 20 min. These were compared with a Cooked-control (80 °C at 0. Read More

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LF H NMR T relaxation rate as affected by water addition, NaCl and pH in fresh, frozen and cooked minced hake.

Food Chem 2019 Mar 23;277:229-237. Epub 2018 Oct 23.

Institute of Food Science, Technology and Nutrition, Consejo Superior de Investigaciones Científicas (ICTAN-CSIC), Calle José Antonio Novais 10, 28040 Madrid, Spain. Electronic address:

Low-Field Nuclear Magnetic Resonance of proton transverse relaxation signal (T) was monitored in hake (Merluccius merluccius) mince with different thermal histories (fresh, frozen, cooked) as affected by pH, water and NaCl addition, and it was related to water holding capacity (WHC). Modifications of T signals were found in terms of changes in relaxation times and relative abundance of the relaxation components. The relaxation rate of the major component (1/T) increased significantly upon frozen storage or pH increase, whereas water or NaCl addition had the opposite effect. Read More

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Personalized pathology maps to quantify diffuse and focal brain damage.

Neuroimage Clin 2018 Nov 20. Epub 2018 Nov 20.

MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States; Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland; Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.

Background And Objectives: Quantitative MRI (qMRI) permits the quantification of brain changes compatible with inflammation, degeneration and repair in multiple sclerosis (MS) patients. In this study, we propose a new method to provide personalized maps of tissue alterations and longitudinal brain changes based on different qMRI metrics, which provide complementary information about brain pathology.

Methods: We performed baseline and two-years follow-up on (i) 13 relapsing-remitting MS patients and (ii) four healthy controls. Read More

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November 2018

Effect of Spin Clustering on Basic and Relaxometric Properties of Magnetic Nanoparticles.

J Nanosci Nanotechnol 2019 May;19(5):2950-2962

Departamento de Fisica de la Materia Condensada, Facultad de Ciencias and Instituto de Ciencia de Materiales de Aragón, CSIC Universidad de Zaragoza, 50009 Zaragoza, Spain.

An increasing awareness about novel medical applications of smaller, inorganic-based nanoparticles, possessing unique properties at the nanoscale, has led to a burst of research activities in the development of "nanoprobes" for diagnostic medicine and agents for novel, externally activated therapies. In this research field magnetic nanoparticles are prominent due to fundamental peculiar properties particularly appealing for their use in materials and biomedical applications. Aiming to study the relationship between the topology of the magnetic nanoparticles and their efficacy as MRI contrast agents (relaxometric properties), we prepared three different stable colloidal suspension (ferrofluid) of magnetic nanobeads (MNBs) constituted by a discrete number of maghemite nanoparticles, arranged in disordered clusters or ordered in a polymeric matrix. Read More

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Translation-orientation coupling and Cox-Merz rule of liquid hexane.

J Chem Phys 2018 Nov;149(20):204502

Graduate School of Engineering, Nagoya University, Furo-cho B2-3 (611), Chikusa, Nagoya, Aichi 464-8603, Japan.

Equilibrium and non-equilibrium molecular dynamics simulations are performed on liquid hexane in order to clarify the origin of the Cox-Merz rule of liquids composed of chain-like molecules. The relation between the frequency-dependent complex shear viscosity and the shear-rate dependent nonlinear viscosity follows the Cox-Merz rule as expected. The slowest viscoelastic relaxation mode is explained by the translation-orientation coupling mechanism, and the saturation of the shear-induced orientational order is observed in the non-equilibrium simulation at the onset of the shear thinning. Read More

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November 2018

Deviations of dynamic parameters characterizing enthalpic and dielectric relaxations in glass forming alkyl phosphates.

J Chem Phys 2018 Nov;149(20):204505

State Key Lab of Metastable Materials Science and Technology, College of Materials Science and Engineering, Yanshan University, Qinhuangdao, Hebei 066004, China.

In our recent study [T. Wu , J. Chem. Read More

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November 2018

Atomic scale evidence of the switching mechanism in a photomagnetic CoFe dinuclear Prussian Blue Analogue.

J Am Chem Soc 2018 Dec 2. Epub 2018 Dec 2.

Molecular complexes based on Prussian Blue Analogues have recently attracted considerable interest for their unique bistable properties combined to ultimately reduced dimensions. Here, we investigate the first dinuclear FeCo complex exhibiting both thermal and photomagnetic bistability in solid state. Through an experimental and theoretical approach combining local techniques - X-ray Absorption Spectroscopy (XAS), X-ray Magnetic Circular Dichroism (XMCD) and Ligand Field Multiplet calculations, we were able to evidence the changes occuring at the atomic scale in the electronic and magnetic properties. Read More

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December 2018
2 Reads

Muscular tension significantly affects stability in standing posture.

Gait Posture 2018 Nov 28;68:220-226. Epub 2018 Nov 28.

Universitat Pompeu Fabra, BCN MedTech, Barcelona, Spain.

Background: Muscular co-contraction is a strategy commonly used by elders with the aim to increase stability. However, co-contraction leads to stiffness which in turns reduces stability. Some literature seems to suggest an opposite approach and to point out relaxation as a way to improve stability. Read More

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November 2018
1 Read

Size-Dependent Fault-Driven Relaxation and Faceting in Zincblende CdSe Colloidal Quantum Dots.

ACS Nano 2018 Dec 5. Epub 2018 Dec 5.

Surface chemistry and core defects are known to play a prominent role in governing the photophysical properties of nanocrystalline semiconductors. Nevertheless, investigating them in small nanocrystals remains a complex task. Here, by combining X-ray scattering techniques in the wide- and small-angle regions and using the Debye Scattering Equation (DSE) method of analysis, we unveil a high density of planar defects in oleate-terminated zincblende (ZB) CdSe colloidal quantum dots (QDs) and size-dependent faceting within a square-cuboid morphology. Read More

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December 2018

Guided imagery relaxation therapy on preoperative anxiety: a randomized clinical trial.

Rev Lat Am Enfermagem 2018 Nov 29;26:e3101. Epub 2018 Nov 29.

Universidade Federal do Triângulo Mineiro, Departamento Didático Científico de Enfermagem na Assistência Hospitalar, Uberaba, MG, Brasil.

Objective: to evaluate the effect of relaxation therapy with guided imagery on state anxiety and cortisol in the immediate preoperative period in patients submitted to bariatric surgery by videolaparoscopy.

Method: a randomized, triple-blind clinical trial in a large teaching hospital in the interior of Minas Gerais. Twenty-four patients who would undergo video-laparoscopic bariatric surgery were randomly allocated in two groups, namely 12 in the control group and 12 in the experimental group. Read More

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November 2018
1 Read

Exploring the ultrafast dynamics of a diarylethene derivative using sub-10 fs laser pulses.

Phys Chem Chem Phys 2018 Dec 5. Epub 2018 Dec 5.

Advanced Ultrafast Laser Research Center, University of Electro-Communications, 1-5-1, Chofugaoka, Chofu, Tokyo 182-8585, Japan. and Brain Science Inspired Life Support Research Center, The University of Electro-Communications, 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan and Department of Electrophysics, National Chiao-Tung University, 1001 Ta Hsinchu Rd., Hsinchu 30010, Taiwan and Tokyo University of Science, Institute of Laser Engineering, Osaka University, 2-6 Yamada-oka, Suita, Osaka 565-0971, Japan.

A diarylethene derivative, 1,2-bis(2,4-dimethyl-5-phenyl-3-thienyl)perfluorocyclopentene (DMP), is a photoswitch molecule utilizing a reversible aromatic ring-opening reaction. The quantum yield of the ring-opening reaction is however remarkably low. We investigate the origin of this behaviour by means of ultrafast transient absorption spectroscopy utilizing sub-10 fs pulses, which is an invaluable tool for simultaneously studying both the electronic and the vibrational molecular dynamics. Read More

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December 2018
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Left Ventricular Strain and Relaxation Are Independently Associated with Renal Cortical Perfusion in Hypertensive Patients.

Adv Exp Med Biol 2018 Dec 4. Epub 2018 Dec 4.

Department of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine, Warsaw, Poland.

Renal perfusion, which depends on cardiac function, is a factor conditioning the work of kidneys. The objective of the study was to assess the influence of cardiac function, including left ventricular contractility and relaxation, on renal cortical perfusion in patients with hypertension and chronic kidney disease treated pharmacologically. There were 63 patients (7 F and 56 M; aged 56 ± 14) with hypertension and stable chronic kidney disease enrolled into the study. Read More

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December 2018

Toward F magnetic resonance thermometry: spin-lattice and spin-spin-relaxation times and temperature dependence of fluorinated drugs at 9.4 T.

MAGMA 2018 Dec 4. Epub 2018 Dec 4.

Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Robert Roessle Straße 10, 13125, Berlin, Germany.

Objective: This study examines the influence of the environmental factor temperature on the F NMR characteristics of fluorinated compounds in phantom studies and in tissue.

Materials And Methods: F MR mapping and MR spectroscopy techniques were used to characterize the F NMR characteristics of perfluoro-crown ether (PFCE), isoflurane, teriflunomide, and flupentixol. T and T mapping were performed, while temperature in the samples was changed (T = 20-60 °C) and monitored using fiber optic measurements. Read More

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December 2018

Evidence for solitonic spin excitations from a charge-lattice-coupled ferroelectric order.

Sci Adv 2018 Nov 30;4(11):eaau7725. Epub 2018 Nov 30.

Department of Applied Physics, University of Tokyo, Bunkyo-ku, Tokyo 113-8656, Japan.

Topological defects have been explored in different fields ranging from condensed matter physics and particle physics to cosmology. In condensed matter, strong coupling between charge, spin, and lattice degrees of freedom brings about emergent excitations with topological characteristics at low energies. One-dimensional (1D) systems with degenerate dimerization patterns are typical stages for the generation of topological defects, dubbed "solitons"; for instance, charged solitons are responsible for high electrical conductivity in doped -polyacetylene. Read More

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November 2018
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Vascular Protection by Ethanol Extract of Root Bark: Endothelium-Dependent Relaxation of Rat Aorta and Decrease of Smooth Muscle Cell Migration and Proliferation.

Evid Based Complement Alternat Med 2018 1;2018:7905763. Epub 2018 Nov 1.

College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Muan-gun, Jeonnam 58554, Republic of Korea.

(white mulberry) is native to the northern part of Korea and popularly used as a traditional medicine due to its numerous health benefits against human's disease. However, the possibility that may also affect the cardiovascular system remains unexplored. This study sought to investigate the vascular protective effects of the root bark extract of (MAE). Read More

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November 2018

In-situ Measurement of Self-Atom Diffusion in Solids Using Amorphous Germanium as a Model System.

Sci Rep 2018 Dec 4;8(1):17607. Epub 2018 Dec 4.

AG Mikrokinetik, Institut für Metallurgie, TU Clausthal, Clausthal-Zellerfeld, Germany.

We present in-situ self-diffusion experiments in solids, which were carried out by Focussing Neutron Reflectometry on isotope multilayers. This new approach offers the following advantages in comparison to classical ex-situ measurements: (1) Identification and continuous measurement of a time dependence of diffusivities, (2) significant reduction of error limits of diffusivities, and (3) substantial reduction of the necessary experimental time. In the framework of a case study, yet unknown self-diffusivities in amorphous germanium are measured at various temperatures quasi-continuously, each during isothermal annealing. Read More

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December 2018