2,453 results match your criteria Relapsing Fever

First Data on Aquaporins: Structural, Phylogenetic and Immunogenic Characterisation as Vaccine Targets.

Pathogens 2022 Jun 16;11(6). Epub 2022 Jun 16.

Parasitology Laboratory, Institute of Natural Resources and Agrobiology (IRNASA, CSIC), Cordel de Merinas, 40-52, 37008 Salamanca, Spain.

transmits African swine fever and human relapsing fever in Africa. The elimination of populations from anthropic environments is expected to improve the prevention and control of these diseases. Tick vaccines have emerged as a sustainable method for tick control, and tick aquaporins (AQPs) are promising targets for tick vaccines due to their vital functions, immunogenicity and ease of access by neutralising host antibodies. Read More

View Article and Full-Text PDF

Prevalence of Bacterial and Protozoan Pathogens in Ticks Collected from Birds in the Republic of Moldova.

Microorganisms 2022 May 27;10(6). Epub 2022 May 27.

Bernhard Nocht Institute for Tropical Medicine Hamburg, 20359 Hamburg, Germany.

Epidemiological knowledge on pathogens in ticks feeding on birds in Moldova is scarce. To reduce this gap of information, a total of 640 migrating and native birds of 40 species were caught from 2012 to 2015 and examined for the presence of ticks in the Republic of Moldova. Altogether, 262 ticks belonging to five tick species ( n = 245, n = 12, n = 2, n = 2 (only males), n = 1) were collected from 93 birds. Read More

View Article and Full-Text PDF

Molecular characterization of a novel relapsing fever Borrelia species from the desert cottontail (Sylvilagus audubonii) in New Mexico, USA.

J Wildl Dis 2022 Jun 23. Epub 2022 Jun 23.

KB One Health, LLC, 3244 Reedgrass Court, Fort Collins, Colorado 80521, USA.

The Borrelia genus comprises vector-borne, spirochete bacteria infecting vertebrates worldwide. We characterized a novel relapsing fever Borrelia species from a desert cottontail (Syvilagus audubonii) from New Mexico, United States, using an established multilocus sequence analysis approach. Phylogenetic analysis of the flagellin gene (flaB) and four other protein-coding loci (clpX, pepX, recG, rplB) grouped the novel Borrelia species with hard tick relapsing fever borreliae Borrelia lonestari, Borrelia theileri, and Borrelia miyamotoi. Read More

View Article and Full-Text PDF

Familial Mediterranean fever may mimic acute appendicitis in children.

Pediatr Surg Int 2022 Jun 23. Epub 2022 Jun 23.

Department of Pediatric Surgery, Karolinska University Hospital, Stockholm, Sweden.

Acute appendicitis is the most common surgical emergency in children. Diagnosis and management are often straightforward. However, familial Mediterranean fever is an important condition to consider in the assessment of children with acute abdominal pain, particularly in children with an origin in eastern Mediterranean basin where the disease is common. Read More

View Article and Full-Text PDF

Bacteria and protozoa with pathogenic potential in Ixodes ricinus ticks in Viennese recreational areas.

Wien Klin Wochenschr 2022 Jun 10. Epub 2022 Jun 10.

Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Kinderspitalgasse 15, 1090, Vienna, Austria.

Ixodes ricinus is the most relevant vector for tick-borne diseases in Austria and responsible for the transmission of Borrelia burgdorferi sensu lato (s. l.), which causes Lyme borreliosis in humans; however, also other bacteria and protozoa can be found in ticks and have the potential of infecting people and animals. Read More

View Article and Full-Text PDF

Historical overview and update on relapsing fever group Borrelia in Latin America.

Parasit Vectors 2022 Jun 8;15(1):196. Epub 2022 Jun 8.

Latin American Group for the Study of Ornithodoros-borne Borrelioses (Grupo Latinoamericano Para el Estudio de Borreliosis Transmitidas Por Ornithodoros [GLEBTO]), Bogotá, Colombia.

Relapsing fever group Borrelia (RFGB) are motile spirochetes transmitted to mammalian or avian hosts through the bite of hematophagous arthropods, such as soft ticks (Argasidae), hard ticks (Ixodidae) and the human clothing lice. RFGB can infect pets such as dogs and cats, as well as birds, cattle and humans. Borrelia recurrentis, B. Read More

View Article and Full-Text PDF

Clinical and Magnetic Resonance Imaging Characteristics of Pediatric Acute Disseminating Encephalomyelitis With and Without Antibodies to Myelin Oligodendrocyte Glycoprotein.

Front Pediatr 2022 20;10:859932. Epub 2022 May 20.

Department of Neurology, Tianjin Children's Hospital (Tianjin University Children's Hospital), Tianjin, China.

Background: Myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG)-associated disorders (MOGADs) have been considered as a new inflammatory disease entity of the central nervous system (CNS) and have heterogeneous clinical and imaging presentations. Acute disseminated encephalomyelitis (ADEM) is one of the most important phenotypes. Our research is aimed to compare the clinical and magnetic resonance imaging (MRI) characteristics of ADEM with or without MOG-IgG in pediatric-acquired demyelinating syndromes (ADSs). Read More

View Article and Full-Text PDF

Comparative genomics of the Western Hemisphere soft tick-borne relapsing fever borreliae highlights extensive plasmid diversity.

BMC Genomics 2022 May 31;23(1):410. Epub 2022 May 31.

Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

Background: Tick-borne relapsing fever (TBRF) is a globally prevalent, yet under-studied vector-borne disease transmitted by soft and hard bodied ticks. While soft TBRF (sTBRF) spirochetes have been described for over a century, our understanding of the molecular mechanisms facilitating vector and host adaptation is poorly understood. This is due to the complexity of their small (~ 1. Read More

View Article and Full-Text PDF

Rituximab-induced serum sickness in a girl with nephrotic syndrome.

CEN Case Rep 2022 May 20. Epub 2022 May 20.

Department of Pediatrics, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan.

Rituximab (RTX) has been used to treat B cell lineage lymphoma/leukemia or autoimmune or autoinflammatory disorders. RTX therapy has been extensively applied to cases of frequently relapsing nephrotic syndrome (FRNS) and steroid-dependent nephrotic syndrome. Rituximab-induced serum sickness (RISS) has been recognized as a rare severe type-3 hypersensitivity reaction in patients treated with RTX. Read More

View Article and Full-Text PDF

Characterization of Immunological Responses to Immunogenic Protein A (BipA), a Species-Specific Antigen for North American Tick-Borne Relapsing Fever.

Microbiol Spectr 2022 May 17:e0172221. Epub 2022 May 17.

Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.

Tick-borne relapsing fever (TBRF) is a neglected vector-borne bacterial disease distributed worldwide. Borrelia turicatae, Borrelia parkeri, and Borrelia hermsii are three argasid-borne TBRF species previously implicated in human disease in North America. TBRF is likely underdiagnosed due to its nonspecific symptoms and poorly developed diagnostic tests. Read More

View Article and Full-Text PDF

Suppressive effects of Ixodes persulcatus sialostatin L2 against Borrelia miyamotoi-stimulated immunity.

Ticks Tick Borne Dis 2022 Jul 29;13(4):101963. Epub 2022 Apr 29.

Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.

Borrelia miyamotoi infection is an emerging tick-borne disease that causes hard tick-borne relapsing fever. B. miyamotoi is transmitted through the bite of ticks, including Ixodes persulcatus. Read More

View Article and Full-Text PDF

Infection and seroprevalence of Borrelia persica in domestic cats and dogs in Israel.

Parasit Vectors 2022 May 10;15(1):102. Epub 2022 May 10.

The Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, P.O. Box 12, 761001, Rehovot, Israel.

Background: Relapsing fever borreliosis is an infectious disease caused by bacteria of the genus Borrelia, inflicting recurrent episodes of fever and spirochetemia in humans. Borrelia persica, the causative agent of relapsing fever in Israel, is prevalent over a broad geographic area that extends from India to Egypt. It is transmitted by the soft tick Ornithodoros tholozani and causes disease in humans as well as domestic cats and dogs. Read More

View Article and Full-Text PDF

Impact of previous disease-modifying treatment on safety and efficacy in patients with MS treated with AHSCT.

J Neurol Neurosurg Psychiatry 2022 May 4. Epub 2022 May 4.

Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Background: Autologous haematopoietic stem cell transplantation (AHSCT) is a highly effective treatment for multiple sclerosis (MS). The impact of previous long-lasting disease-modifying treatments (DMT) for safety and efficacy of AHSCT is unknown.

Objective: To explore whether previous DMTs with long-lasting effects on the immune system (anti-CD20 therapy, alemtuzumab and cladribine) affect treatment-related complications, long-term outcome and risk of new MS disease activity in patients treated with AHSCT. Read More

View Article and Full-Text PDF

Metatranscriptomic profiling reveals diverse tick-borne bacteria, protozoans and viruses in ticks and wildlife from Australia.

Transbound Emerg Dis 2022 May 3. Epub 2022 May 3.

CSIRO, Health and Biosecurity, Canberra, Connecticut, Australia.

Tick-borne zoonoses are emerging globally due to changes in climate and land use. While the zoonotic threats associated with ticks are well studied elsewhere, in Australia, the diversity of potentially zoonotic agents carried by ticks and their significance to human and animal health is not sufficiently understood. To this end, we used untargeted metatranscriptomics to audit the prokaryotic, eukaryotic and viral biomes of questing ticks and wildlife blood samples from two urban and rural sites in New South Wales, Australia. Read More

View Article and Full-Text PDF

Etiological spectrum of persistent fever in the tropics and predictors of ubiquitous infections: a prospective four-country study with pooled analysis.

BMC Med 2022 05 2;20(1):144. Epub 2022 May 2.

Division of Tropical and Humanitarian Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.

Background: Persistent fever, defined as fever lasting for 7 days or more at first medical evaluation, has been hardly investigated as a separate clinical entity in the tropics. This study aimed at exploring the frequencies and diagnostic predictors of the ubiquitous priority (i.e. Read More

View Article and Full-Text PDF

Detection of Borrelia miyamotoi in Ixodes ricinus ticks in Southern Moravia - risk for public health.

Epidemiol Mikrobiol Imunol 2022 ;71(1):57-59

Borrelia miyamotoi is an emerging tick-borne pathogen. The vector is ticks of the Ixodes ricinus complex, causing relapsing fever- like disease and widespread in the temperate zone of the Northern Hemisphere. The present study documents the prevalence of B. Read More

View Article and Full-Text PDF

Case Report: Lyme Borreliosis and Pregnancy - Our Experience.

Front Med (Lausanne) 2022 28;9:816868. Epub 2022 Mar 28.

Department of Medical Sciences, University of Trieste, Trieste, Italy.

Lyme Borreliosis (LB) is an infection transmitted by sp. ticks. Its early manifestation includes erythema migrans rash. Read More

View Article and Full-Text PDF

A Comparative Study of Body Lice and Bed Bugs Reveals Factors Potentially Involved in Differential Vector Competence for the Relapsing Fever Spirochete Borrelia recurrentis.

Infect Immun 2022 May 6;90(5):e0068321. Epub 2022 Apr 6.

University of South Dakotagrid.267169.d, Sanford School of Medicine, Division of Basic Biomedical Sciences, Vermillion, South Dakota, USA.

Borrelia recurrentis is the causative agent of louse-borne relapsing fever and the only species transmitted by an insect rather than a tick vector. While bed bugs (Cimex lectularius L.) are not established vectors of any human pathogens, a recent study reported that they may be competent vectors of B. Read More

View Article and Full-Text PDF

Chinese patients with p.Arg756 mutations of : Clinical manifestations, treatment, and follow-up.

Pediatr Investig 2022 Mar 25;6(1):5-10. Epub 2022 Feb 25.

Department of Neurology Beijing Children's Hospital, Capital Medical University, National Center for Children's Health Beijing China.

Importance: The phenotypes of gene mutations are diverse. Relapsing encephalopathy with cerebellar ataxia and fever-induced paroxysmal weakness and encephalopathy (FIPWE) are considered non-classical phenotypes caused by p.Arg756 mutations of . Read More

View Article and Full-Text PDF

The influence of local environmental factors in southwestern Poland on the abundance of Ixodes ricinus and prevalence of infection with Borrelia burgdorferi s.l. and B. miyamotoi.

Parasitol Res 2022 Jun 26;121(6):1575-1585. Epub 2022 Mar 26.

Department of Bioinformatics and Genomics, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383, Wroclaw, Poland.

Ticks are important ectoparasites and vectors of pathogens that cause disease in humans and animals. The natural habitat of Ixodes ricinus ticks is forests, which are convenient habitats to search for hosts, including reservoir hosts, and therefore can be an important habitat source of tick-borne pathogens. The aim of the study was to assess the usefulness of detailed forest habitat-type maps to estimate the tick-borne risk at a local scale (Lower Silesia, SW Poland). Read More

View Article and Full-Text PDF

Early Transcriptional Changes in the Midgut of after Feeding and Infection with .

Microorganisms 2022 Feb 28;10(3). Epub 2022 Feb 28.

Institute of Infectology, Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany.

Studies on tick-pathogen-host interactions are helping to identify candidates for vaccines against ticks and tick-borne diseases and to discover potent bioactive tick molecules. The tick midgut is the main tissue involved in blood feeding and, moreover, the first organ to have contact with pathogens ingested through the blood meal. As little is known about the molecular biology of feeding and tick defence mechanisms against microorganisms, but important for understanding vector-pathogen interactions, we explored the early transcriptional changes in the midgut of after feeding and in response to challenge with the relapsing-fever spirochete using the Ion S5XL platform. Read More

View Article and Full-Text PDF
February 2022

Frequency and Geographic Distribution of Borrelia miyamotoi, Borrelia burgdorferi, and Babesia microti Infections in New England Residents.

Clin Infect Dis 2022 Mar 23. Epub 2022 Mar 23.

Yale School of Public Health, Department of Epidemiology of Microbial Diseases and Yale School of Medicine, New Haven, Connecticut, USA.

Background: Borrelia miyamotoi is a relapsing fever spirochete that relatively recently has been reported to infect humans. It causes an acute undifferentiated febrile illness that can include meningoencephalitis and relapsing fever. Like Borrelia burgdorferi, it is transmitted by Ixodes scapularis ticks in the northeastern United States and by Ixodes pacificus ticks in the western United States. Read More

View Article and Full-Text PDF

New records of soft ticks (Acari: Argasidae) in the Caatinga biome of Brazil, with a phylogenetic analysis of argasids using the nuclear Histone 3 (H3) gene.

Exp Appl Acarol 2022 Apr 19;86(4):567-581. Epub 2022 Mar 19.

Department of Preventive Veterinary Medicine and Animal Health, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, Av. Orlando Marques de Paiva, 87, Cidade Universitária, São Paulo, SP, 05508-270, Brazil.

In Brazil, 19 species of the genus Ornithodoros (Acari: Argasidae) have been reported. The medical and veterinary importance of Ornithodoros ticks has increased substantially in recent decades, with the discovery of various relapsing fever Borrelia infecting Ornithodoros ticks. Herein, argasid ticks were collected during 2019-2020 from caves, abandoned nests and homes in various regions of Ceará State, Brazilian semiarid-Caatinga biome. Read More

View Article and Full-Text PDF

Mechanism of Borrelia immune evasion by FhbA-related proteins.

PLoS Pathog 2022 03 18;18(3):e1010338. Epub 2022 Mar 18.

Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.

Immune evasion facilitates survival of Borrelia, leading to infections like relapsing fever and Lyme disease. Important mechanism for complement evasion is acquisition of the main host complement inhibitor, factor H (FH). By determining the 2. Read More

View Article and Full-Text PDF

[Acute disseminated encephalomyelitis].

Radiologe 2022 Apr 15;62(4):316-321. Epub 2022 Mar 15.

Klinik für Diagnostische und Interventionelle Neuroradiologie, Uniklinikum des Saarlandes, Kirrbergerstraße 1, 66421, Homburg/Saar, Deutschland.

Background: Acute disseminated encephalomyelitis (ADEM) is a rare demyelinating disease that occurs predominantly in children. According to the guidelines, ADEM belongs to the myelin oligodendrocyte glycoprotein (MOG)-associated diseases and usually manifests after febrile infections (also after SARS-CoV-2) or postvaccinally.

Objectives: Incidence, course and clinical, and as well, as radiological features and new developments and treatment of ADEM. Read More

View Article and Full-Text PDF

The arginine deaminase system plays distinct roles in Borrelia burgdorferi and Borrelia hermsii.

PLoS Pathog 2022 03 14;18(3):e1010370. Epub 2022 Mar 14.

Laboratory of Bacteriology, Gene Regulation Section, Division of Intramural Research, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America.

Borrelia species are amino acid auxotrophs that utilize di- and tri- peptides obtained through their oligopeptide transport system to supply amino acids for replicative growth during their enzootic cycles. However, Borrelia species from both the Lyme disease (LD) and relapsing fever (RF) groups harbor an amino acid transport and catabolism system, the Arginine Deiminase System (ADI), that could potentially augment intracellular L-arginine required for growth. RF spirochetes contain a "complete", four gene ADI (arcA, B, D, and C) while LD spirochetes harbor arcA, B, and sometimes D but lack arcC (encoding carbamate kinase). Read More

View Article and Full-Text PDF

Typhoid fever presenting with gastric ulcer bleeding.

BMC Gastroenterol 2022 Mar 10;22(1):116. Epub 2022 Mar 10.

Division of Gastroenterology, Department of Internal Medicine, Chungnam National University Hospital, 282, Munhwa-ro, Jung-gu, Daejeon, 35015, Republic of Korea.

Background: Enteric fever is a systemic disease caused by Salmonella enterica serovar Typhi or Salmonella enterica serovar Paratyphi, characterized by high fever and abdominal pain. Most patients with enteric fever improve within a few days after antibiotic treatment. However, some patients do not recover as easily and develop fatal life-threatening complications, including intestinal hemorrhage. Read More

View Article and Full-Text PDF

Multiple Drug Regimen-Refractory Rosai-Dorfman-Destombes Disease Mimicking Relapsing Polychondritis Successfully Treated with Cobimetinib.

Eur J Case Rep Intern Med 2022 4;9(2):003076. Epub 2022 Feb 4.

Department of Internal Medicine, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.

Rosai-Dorfman-Destombes disease (RDD) or sinus histiocytosis with massive lymphadenopathy is a rare non-Langerhans cell histiocytosis of unknown cause. The disease often manifests as painless bilateral cervical lymphadenopathy associated with systemic symptoms such as fever and weight loss. Extranodal disease is also frequent and can involve any organ, mostly the skin, nasal cavity, bone, and retro-orbital tissue. Read More

View Article and Full-Text PDF
February 2022

Fingolimod in Multiple Sclerosis and Familial Mediterranean Fever Coexistence.

Sevda Diker

Neurol India 2022 Jan-Feb;70(1):392-394

Department of Neurology, Faculty of Medicine, Near East University, Nicosia, Cyprus.

Background: There is an intriguing relationship between familial Mediterranean fever (FMF) and multiple sclerosis (MS). While FMF is a hereditary autosomal recessive disease characterized by recurrent, acute, self-limited attacks of fever and polyserositis, MS is a chronic, inflammatory demyelinating disease of the central nervous system, characterized by autoreactive lymphocytes, microglial activation, and chronic neurodegeneration. In patients suffering from both FMF and MS, it would be interesting to test whether treatments for MS affect the course of FMF, or vice versa. Read More

View Article and Full-Text PDF

A man in his sixties with chondritis and bone marrow failure.

Tidsskr Nor Laegeforen 2022 03 28;142(4). Epub 2022 Feb 28.

Background: VEXAS syndrome (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic syndrome) first described in 2020, is caused by a limited repertoire of somatic mutations in UBA1, a gene involved in the initiation of ubiquitination. Ubiquitination, adding an ubiquitin protein to a substrate protein, can have various effects on the substrate. Disruption of UBA1 function results in diverse clinical manifestations, mimicking a variety of disorders. Read More

View Article and Full-Text PDF