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Rejuvenation Res 2019 Feb 2. Epub 2019 Feb 2.

Xijing Hospital, Fourth Military Medical University, Department of pharmacy , Changle West Street 15, Xi'an, Shaanxi 710032, China , Xian, China , 710032 ;

Ischemic stroke is a common cerebrovascular disease with high morbidity and mortality worldwide. However, treatment options for reducing cerebral ischemia-reperfusion injury (CIRI) are limited. Gallic acid (GA) as a plant polyphenol has been used to fight against CIRI. Read More

Rejuvenation Res 2019 Feb 2. Epub 2019 Feb 2.

Shanghai University of Medicine and Health Sciences, 191610 , 279 Zhouzhu Hwy , Shanghai, Shanghai, China , 201318.

In recent years, the clinical application of circulating tumor cell (CTCs) detection has become one of the research hotspots in the field of precision medicine. CTCs detection is non-invasive, easy to obtain, can be repeatedly collected, highly repeatable and other advantages. It not only can be a real-time comprehensive monitoring of cancer treatment, but also have a large number of applications, including early diagnosis of tumor, timely evaluation of efficacy, condition monitoring, resistance factor analysis, prognosis judgment, individualized treatment of tumors, drug guidance, etc. Read More

Rejuvenation Res 2019 Feb;22(1):79-81

1 Gerontology Research Group, Sandy Springs, Georgia.

Rejuvenation Res 2019 Feb;22(1):3-12

Moscow Society of Naturalists, Moscow, Russia.

I present a body of data that, I argue, cumulatively casts serious doubt on the validity of Jeanne Calment's accepted world record of human life span. First, I assess the plausibility of the record based on the life spans of other centenarians in the International Database of Longevity (IDL) and critique some arguments put forward previously in support of that plausibility, including the longevity of Calment's ancestors. Second, I review the literature dedicated to Calment and discuss multiple contradictions in her interviews, biographies, photos, and documents. Read More

Rejuvenation Res 2019 Feb;22(1):1-2

SENS Research Foundation, Mountain View, California.

Rejuvenation Res 2019 Jan 29. Epub 2019 Jan 29.

West China Hospital, Sichuan University, Center of Gerontology and Geriatrics , No. 37, Guo Xue Xiang Renmin Nan Lu , Chengdu, China , 610041.

Frailty, one appealing target for improving successful aging of the elderly population, is a common clinical syndrome based on the accumulation of multisystemic function declines and the increase in susceptibility to stressors during biological aging. The age-dependent senescence, the frailty-related stem cell depletion, chronic inflammation, imbalance of immune homeostasis, and the reduction of multipotent stem cells, collectively suggest the rational hypothesis that it is possible to (partially) cure frailty with stem cells. This systematic review has included all of the human trials of stem cell therapy for frailty from the main electronic databases and printed materials and screened the closely related reviews themed on the mechanisms of aging, frailty, and stem cells, to provide more insights in stem cell strategies for frailty, one promising method to recover health from a frail status. Read More

Rejuvenation Res 2019 Feb;22(1):82-88

Theses reviewed in this issue include Characterization and Modeling of Metabolic Stress Responses in Cellular Aging; Engineering Immunity: Enhancing T Cell Vaccines and Combination Immunotherapies for the Treatment of Cancer; Extracellular Inflammatory Signaling from Dysfunctional Telomeres; High-Throughput Microfluidic Labyrinth for the Label-Free Isolation of circulating tumor cells for Single-Cell Gene Expression Profiling; Oxygen Nanobubbles for Ultrasound-guided Targeting of Cancer Hypoxia; and The Eye as a Window to the Alzheimer's Disease Brain. Read More

Rejuvenation Res 2019 Jan 23. Epub 2019 Jan 23.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences , No. 16, Nanxiaojie, Dongzhimennei , Beijing, China , 100700 ;

Radix paeoniae alba (RPA) and Veratrum nigrum L. (VN) belong to the eighteen incompatible medicaments and have been prohibited for thousands of years in China. Previous studies focused on the chemical constituents induced the toxicological response of the two agents, but this study offers preliminary insight into the pharmacodynamics and mechanism on estrogenic activity which is responsible for their incompatibility. Read More

Rejuvenation Res 2019 Jan 23. Epub 2019 Jan 23.

University of Granada, Physiology, Granada, Spain ;

The α-Klotho gene was identified as a possible "ageing-suppressor" agent that extends lifespan when overexpressed. However, little is known about the association of the body composition with the secreted protein form of the α-Klotho gene (S-Klotho). Therefore, the aim of this study was to analyse the association of body composition including lean and fat mass as well as bone mineral density (BMD) with S-Klotho plasma levels in middle-aged sedentary adults. Read More

Rejuvenation Res 2019 Jan 19. Epub 2019 Jan 19.

Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan ;

Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase, being involved in endothelial dysfunction. Furthermore, ADMA levels have been shown to predict future cardiovascular events in patients with coronary risk factors, such as diabetes and hypertension. We have previously found that glyceraldehyde-derived advanced glycation end products (glycer-AGEs) stimulate ADMA generation in vitro and the levels are associated with ADMA, endothelial dysfunction and vascular inflammation in humans. Read More

Rejuvenation Res 2019 Jan 11. Epub 2019 Jan 11.

Guangxi Medical University, College of Public Hygiene , No.22 Shuangyong Road , Nanning, Guangxi, China , 530021 ;

MicroRNAs (miRNAs) is an endogenous non-coding small molecule RNA that regulates cell proliferation, differentiation, fat metabolism and hormone secretion. Studies have shown that miRNAs regulate the processes related to osteoporosis, including the differentiation of osteoblasts, osteoclasts and chondrocytes, and are one of the important regulatory factors of some bone metabolic diseases. In our previous study has revealed that natural compound Polygonatum sibiricum polysaccharide (PSP) can promote osteoblast formation and blocking osteoclastogenesis through Wnt/β-catenin signalling pathway. Read More

Rejuvenation Res 2019 Feb 4. Epub 2019 Feb 4.

Department of Medical Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Circadian rhythms (CRs) are intrinsic clocks organizing the behavior and physiology of organisms. These clocks are thought to have coevolved with cellular redox regulation. Metabolism, redox homeostasis, circadian clock, and diet offer insights into aging. Read More

Rejuvenation Res 2019 Feb 11. Epub 2019 Feb 11.

2 Department of Cardiac Surgery, University of Rome "Tor Vergata," Rome, Italy.

The emerging evidence emphasizes Red blood cell distribution width (RDW) as optimal prognostic biomarker for cardiovascular diseases. However, several clinical biases impede its clinical application. Recent recommendations suggest combining RDW with other biomarkers. Read More

Rejuvenation Res 2019 Jan 24. Epub 2019 Jan 24.

1 Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University , Tianjin, China .

Epidemiological studies report that more than half of the people over the age of 65 years suffer from variable sleep problems. In this study, we conducted a cohort study to investigate the relationship between sleep duration, muscle mass, and function within a community-dwelling, elderly Chinese population. Our study population consisted of residents living in the township central hospital of suburban Tianjin, China. Read More

Rejuvenation Res 2019 Jan 24. Epub 2019 Jan 24.

Division of Cardiology, Department of Medicine, Karolinska Institutet, Heart and Vascular Theme, Karolinska University Hospital , Stockholm, Sweden .

Reduced bioavailability of nitric oxide (NO) is accompanied by endothelial dysfunction, which precedes clinical signs of atherosclerosis. The metalloenzyme arginase reciprocally inhibits the formation of NO and available data demonstrate that arginase contributes to reduced bioavailability of NO and increases the formation of reactive oxygen species. Emerging evidence suggests that arginase thereby plays a key role in the pathophysiology of age-associated vascular complications in animal models. Read More

Rejuvenation Res 2018 12;21(6):495-496

SENS Research Foundation, Mountain View, California.

Rejuvenation Res 2018 Dec;21(6):560-571

1 Ichor Therapeutics, Inc., Lafayette, New York.

Macular degeneration is hallmarked by retinal accumulation of toxic retinoid species (e.g., A2E) for which there is no endogenous mechanism to eliminate it. Read More

Rejuvenation Res 2018 Dec;21(6):572-579

1 Panorama Research Institute, Sunnyvale, California.

Neuroinflammation is thought to play a key role in the progression of neurodegenerative disease such as Alzheimer's disease (AD). Given the apparent nexus of inflammatory disease with the secretory-associated senescence phenotype (SASP) of cellular senescence, two reports found that tau-mediated neurodegeneration involves induction of senescence in astrocytes, microglia, and possibly even neurons. Elimination of senescent cells by pharmacologically induced genetic ablation or by senolytic drugs blocks progression of mutant human tau-mediated neurodegeneration in mice. Read More

Rejuvenation Res 2018 Dec;21(6):580-586

Theses reviewed in this issue include "A Thromboresistant Cell-Derived Biomaterial Modification for Vascular Grafts," "Actomyosin Mediated Tension Orchestrates Thermogenic Programs in Adipocytes," "Age-Associated Changes in Intrathymic B Cell Population in Mice," "Endoplasmic Reticulum Stress Is Transmissible Among Cells of the Central Nervous System," "Evaluation of Early Tumor Angiogenesis Using Ultrasound Acoustic Angiography," and "Interactions Between Amyloid-Beta and Microglial Cells." Read More

Rejuvenation Res 2019 Jan 9. Epub 2019 Jan 9.

Department of Biochemistry, University of Allahabad, Allahabad, India.

Caloric restriction mimetics (CRMs) provide an exciting antiaging intervention strategy. 2-Deoxy-D-glucose (2-DG), a glycolytic inhibitor, is known to work as a CRM at high doses; however, at chronic high dose it has been linked to increased mortality in rats. We have investigated chronic low-dose dietary administration of 2-DG on age-related stress protection in young and old male Wistar rats by evaluating age-dependent biomarkers in plasma and erythrocytes. Read More

Rejuvenation Res 2018 Nov 16. Epub 2018 Nov 16.

Shanghai University of Medicine and Health Sciences, 191610, Department of Clinical and Basic Sciences, Shanghai, Shanghai, China.

Purpose Our prospective, comparative study of 60 patients aimed to compare the efficacy and feasibility of a single injection ranibizumab vs a single grid laser photocoagulation and vs. a combined treatment in macular edema secondary to branch retinal vein occlusion in Asian population. Methods Patients were randomized 1:1:1 (n=20/group) into laser (LAS), the ranibizumab (RAN) and the combination (COM) group. Read More

Rejuvenation Res 2018 Dec 28. Epub 2018 Dec 28.

1 Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

It is known that preconditional treatment with volatile anesthetics can induce tolerance of the brain to stroke. A previous study demonstrated that the involvement of TREK-1, a two-pore domain K+ channel, in sevoflurane preconditioning induced neuroprotection against focal cerebral ischemia in rats. The present study testified whether TREK-2, another anesthetic-target K+ channel, is also associated with volatile anesthetic-induced neuroprotection, and further explored its potential mechanism. Read More

Rejuvenation Res 2018 Dec 28. Epub 2018 Dec 28.

1 Department of Cardiology, Xi'an No.1 Hospital, Xi'an, China.

Salviae miltiorrliza-borneol Jun-Shi coupled-herbs have been widely used for treatment of ischemia stroke. Salvianolic acid B was the most abundant and bioactive compound of Salviae miltiorrliza and used for prevention and treatment of cerebrovascular diseases. However, the scientific intension and compatible mechanism of Salvianolic acid B - borneol combination were still unknown. Read More

Rejuvenation Res 2018 Nov 6. Epub 2018 Nov 6.

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, zhengzhou, China ;

Walnuts kernels (Juglans regia L.) have rich antioxidants content and have been used in both cosmetic and pharmaceutical industry. The current study dealt with the protective role of walnut kernels extracts (WK) on isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Read More

Rejuvenation Res 2018 Dec 28. Epub 2018 Dec 28.

6 SESPA, Health Service of the Principality of Asturias , Oviedo, Spain .

The multidimensional prognostic index (MPI) is a comprehensive geriatric assessment (CGA)-based tool that accurately predicts negative health outcomes in older subjects with different diseases and settings. To calculate the MPI several validated tools are assessed by health care professionals according to the CGA, whereas self-reported information by the patients is not available, but it could be of importance for the early identification of frailty. We aimed to develop and validate a self-administered MPI (SELFY-MPI) in community-dwelling subjects. Read More

Rejuvenation Res 2018 Dec 26. Epub 2018 Dec 26.

1 School of Biosciences & Biopharmaceutics and Center for Bioresources & Drug Discovery, Guangdong Pharmaceutical University, Guangzhou, China.

Liver cells are easily damaged by oxidative stress during progression both in liver development and throughout adult life, resulting in tissue pathology that ranges from simple hepatitis to nonalcoholic fatty liver disease. In this study, we determined the attenuation of oxidative stress in liver cells with pretreatment of rosmarinic acid (RA), which is an antioxidant agent from Rosmarinus officinalis. The human liver cell line L02 was damaged by hydrogen peroxide (HO). Read More

Rejuvenation Res 2019 Jan 8. Epub 2019 Jan 8.

4 Arnie Miller Laboratories, Beer-Sheva, Israel.

Crude ethanolic extracts from Phlomis viscosa Poiret leaves from the Judea region (Israel) are renowned for their remarkable geroprotective properties: anti-inflammatory, anti-diabetic, and anti-cancer. A phytochemical investigation carried out in this study revealed that the tested plant might belong to a particular distinct chemotype because its phytochemicals are different from compounds that were mentioned in the literature. Among the compounds identified by us was diosmin, the synthetic derivatives of which were further obtained and investigated. Read More

Rejuvenation Res 2018 Oct 21. Epub 2018 Oct 21.

Washington University (St Louis), Biology , 654 Carpenter Ln , Philadelphia , Philadelphi, Pennsylvania, United States , 19119.

Recent advances in technology of "aging clocks" based on DNA methylation suggest that it may be possible to measure changes in the rate of human aging over periods as short as a year or two. To the extent that methylation is a valid surrogate for biological age, testing of anti-aging interventions has become radically cheaper and faster. Together with colleagues at UCLA and UCSD, I have initiated a clinical trial to evaluate some of the most popular anti-aging strategies currently deployed by "early adopters" in the lay community of personal health activists. Read More

Rejuvenation Res 2018 Oct 17. Epub 2018 Oct 17.

Ben-Gurion University of the Negev, 26732, Family Medicine and Siaal Research Center for Family Practice and Primary Care, Beer-Sheva, Israel.

Aim: Studies of the effect of aromatherapy on patients with behavioral and psychological symptoms of dementia (BPSD) have yielded contradictory results. One possible explanation for this lack of consistent results is the site of application of the oil. The aim of the study was to evaluate the effect of lavender oil on the rate of BPSD when applied close to and away from the olfactory system. Read More

Rejuvenation Res 2018 10;21(5):387-388

SENS Research Foundation , Mountain View, California.

Rejuvenation Res 2018 Oct;21(5):477-481

1 Panorama Research Institute , Sunnyvale, California.

Prevention of cell senescence is a potential means to extend healthspan and perhaps lifespan. Agents that increase NAD+ levels, which are diminished with age, may be senopreventive through restoration of SIRT1 and normal mitochondrial activity. The ketone body [Formula: see text]-hydroxybutyrate ([Formula: see text]-HB) prevents senescence by inducing quiescence in endothelial cells. Read More

Rejuvenation Res 2018 Oct 9;21(5):482-487. Epub 2018 Oct 9.

Theses reviewed in this issue include "Computational Pathology for Quantifying Spatial Heterogeneity in Digital Images of Tissue Sections from Solid Tumors," "Molecular Analysis of Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Brain Tissue Identifies Disease Mechanisms Associated with Repetitive DNA Elements," "Neuroprotective Potential of the N-Terminal Beta Amyloid Peptide Fragment in the Neurodegeneration, Synaptic Dysfunction and Memory Deficits in Models of Alzheimer's Disease," "pH-triggered Self-Assembly of a PEGylated Peptide Amphiphilic Contrast Agent," "Quantitative Approaches for Profiling the T Cell Receptor Repertoire in Human Tissues," and "Regulation and Repair of Neural Stem Cells and the Neurogenic Niche." Read More

Rejuvenation Res 2018 Oct 24. Epub 2018 Oct 24.

1 Department of Pharmacy, Xijing Hospital, The Fourth Military Medical University , Xian, China .

Fibrosis is the major pathological feature of chronic kidney disease (CKD). Aloe-emodin (AE), one of the main active compounds in Rhubarb, is widely used for renal protection. However, mechanisms implied in the modulation of kidney fibrosis after AE treatment for CKD remain elusive. Read More

Rejuvenation Res 2018 Nov 7. Epub 2018 Nov 7.

Institute of Pharmaceutical Chemistry, University of Münster , Münster, Germany .

Extension of the healthy life span is of primary importance for the aging society. Among exercise, healthy nutrition, and mental training, food supplements are widely used as preventive measures to postpone the diverse symptoms of aging. The extract from the bark of the French maritime pine, Pycnogenol, rich on flavonoids, has anti-inflammatory and antioxidative property, proven in in vivo studies. Read More

Rejuvenation Res 2018 Oct 25. Epub 2018 Oct 25.

1 Technical Center for Animal , Plant and Food Inspection and Quarantine, Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai, China .

Although the health benefits attributed to urolithin A, such as anticancer, anti-inflammatory, and antioxidant effects, are based on numerous, diverse studies carried out in vitro, the biological effects of urolith A are still not entirely understood. In this study, we explored the biological effects of urolithin A using senescent human skin fibroblasts (HSFs) to determine whether urolithin A has any antiaging potential. Our results showed that urolithin A significantly increased type I collagen expression and reduced matrix metalloproteinase 1 (MMP-1) expression. Read More

Rejuvenation Res 2018 Oct 18. Epub 2018 Oct 18.

2 Kevser Ermin Applied Physiology Laboratory, Department of Health, Exercise Science, and Recreation Management, The University of Mississippi , University, Mississippi.

The relationship between grip strength and mortality is often used to underscore the importance of resistance exercise in physical activity guidelines. However, grip strength does not appear to appreciably change following traditional resistance training. Thus, grip strength could be considered reflective of strength independent of resistance exercise. Read More

Rejuvenation Res 2018 Oct 11. Epub 2018 Oct 11.

1 Department of Biotechnology, Jaypee Institute of Information Technology , Noida, India .

In this work, poly (d,l-lactide-co-glycolic acid) (PLGA) nanoparticles of baclofen (Bcf-PLGA-NPs) were developed and optimized using nanoprecipitation method. The average particle size of the Bcf-PLGA-NP was found to be 124.8 nm, polydispersity index of 0. Read More

Rejuvenation Res 2018 Aug 24. Epub 2018 Aug 24.

University of Oxford, Orthopaedics, Rheumatology and Musculoskeletal Sciences , NOC , Oxford, United Kingdom of Great Britain and Northern Ireland , OX4 1ED ;

Based on experience and the existing limited research literature in biotechnology corporate governance, the authors propose potential attributes of minimum corporate governance standards for biotechnology companies, as a basis for further quantitative and qualitative research. The authors assert that the recent proliferation of biotechnology start-up organisations is substantively changing inter- and intra-organizational cultures throughout the healthcare sector via a 'cascade of governance'. Therefore, governance decisions and actions - both positive and negative - that are instituted in start-up biotech companies may set new norms for other start-up biotech companies, the larger (bio)pharmaceutical companies by which they are acquired and the range of healthcare sub-sector actors that interact with biotechnology companies. Read More

Rejuvenation Res 2018 Oct 13. Epub 2018 Oct 13.

9 Department of Pathobiology and Medical and Forensic Biotechnologies, University of Palermo , Palermo, Italy .

Evidence suggests association of red blood cell distribution width (RDW) with cardiovascular diseases (CVDs). On the contrary, we underline that the sole RDW values cannot represent a valid CVD biomarker. High RDW values are expression of biological effects of a lot of both endogenous and exogenous factors (i. Read More

Rejuvenation Res 2018 Oct 18. Epub 2018 Oct 18.

Department of Political Studies, Queen's University , Kingston, Canada .

In this article, I argue that senescence (biological aging) is one of the greatest threats to human freedom in the 21st century. The two most prominent conceptions of freedom are "negative" and "positive" liberty. The negative conception of liberty equates freedom with the absence of interference, whereas the positive conception equates freedom with having the capacity to be self-determining. Read More

Rejuvenation Res 2018 Oct 23. Epub 2018 Oct 23.

2 Centre for Healthy Brain Ageing, University of New South Wales , School of Psychiatry, Sydney, Australia .

Nicotinamide adenine dinucleotide (NAD) is an essential pyridine nucleotide that serves as an electron carrier in cellular metabolism and plays a crucial role in the maintenance of balanced redox homeostasis. Quantification of NAD:NADH and NADP:NADPH ratios are pivotal to a wide variety of cellular processes, including intracellular secondary messenger signaling by CD38 glycohydrolases, DNA repair by poly(adenosine diphosphate ribose) polymerase (PARP), epigenetic regulation of gene expression by NAD-dependent histone deacetylase enzymes known as sirtuins, and regulation of the oxidative pentose phosphate pathway. We quantified changes in the NAD metabolome in plasma samples collected from consenting healthy human subjects across a wide age range (20-87 years) using liquid chromatography coupled to tandem mass spectrometry. Read More

Rejuvenation Res 2018 Aug 9. Epub 2018 Aug 9.

University of Oxford, Oxford, United Kingdom of Great Britain and Northern Ireland ;

Data and Corporate Governance in Pharma and Digital Health: A Necessary Regulatory Convergence. Read More

Rejuvenation Res 2018 Oct 6. Epub 2018 Oct 6.

2 Laboratory of Molecular Neuroscience, Kerman Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences , Kerman, Iran .

Parkinson's disease (PD) is a destroying and prevalent neurodegenerative disease that is characterized by a progressive death of midbrain dopaminergic neurons. It is important to understand the possible neuroprotective effects of reagents that rescue the neurons from death and apoptosis. In this study, we investigated the effects of abscisic acid (ABA) on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in human dopaminergic neuroblastoma SH-SY5Y cell line as an in vitro model of PD. Read More

Rejuvenation Res 2018 08;21(4):291-293

1 Department of Paediatrics, Healthcare Translation Research Group, University of Oxford , Oxford, United Kingdom .

Rejuvenation Res 2018 Aug;21(4):374-379

Theses reviewed in this issue include "Bowties, Barcodes, and DNA Origami: A Novel Approach for Paired-Chain Immune Receptor Repertoire Analysis," "Development of Canine Chimeric Antigen Receptor T Cell Therapy for Treatment & Translation," "Endocytic Vesicle Rupture in the Pathogenesis and Propagation of Neurodegenerative Proteinopathies," "Exploring Mechanisms of Metastasis Suppression in Metastatic Melanoma," "Polymer and Nucleic Acid Self-Assemblies: Properties and Applications at the Biological Interface," and "Towards a Scalable, Biomimetic, Antibacterial Coating." Read More

Rejuvenation Res 2018 Aug;21(4):369-373

1 Panorama Research Institute , Sunnyvale, California.

Mitochondrial-derived peptides (MDPs), encoded by mitochondrial DNA, play a cytoprotective role by helping preserve mitochondrial function and cell viability under stressful conditions. Humanin and its homologs and MOTS-c are two of several MDPs hypothesized to have antiaging activity based on correlative studies. For example, humanin plasma levels are inversely correlated with growth hormone and insulin-like growth factor 1 expression, which may promote accelerated aging. Read More

Rejuvenation Res 2018 Sep 20. Epub 2018 Sep 20.

2 Complex Structure of Geriatrics, Department of Medical Sciences, IRCCS "Casa Sollievo della Sofferenza," San Giovanni Rotondo, Italy .

This study aimed to identify and describe the fundamental characteristics of spoken dialogue systems, and their role in supporting human-robot interaction and enabling the communication between socially assistive robots and patients with dementia. First, this work provides an overview of spoken dialogue systems by considering the underlying technologies, approaches, methods, and general issues. Then, the analysis focuses on studies, systems, and approaches that have investigated the role of dialogue systems and conversational agents in the interaction with elderly people with dementia by presenting the results of a literature review. Read More

Rejuvenation Res 2018 Aug 29. Epub 2018 Aug 29.

1 Institute of Chinese Medicine, Heilongjiang University of Chinese Medicine , Harbin, China .

Kaixin-San (KXS), a Chinese formula, was used to treat "amnesia," a senile dementia in the modern world. This formula was reported to improve behavioral performances in many animal models. This study was designed to explore how KXS has improved amyloid-β (Aβ)-induced memory dysfunction in mice. Read More

Rejuvenation Res 2019 Feb 23;22(1):20-30. Epub 2018 Aug 23.

1 Department of Physiology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Aging causes the degeneration of organs of the locomotor system, including the cerebellum and bones. Exercise may reverse this deterioration. d-galactose has been frequently used in rodents to accelerate aging. Read More