6,308 results match your criteria Rejuvenation Research [Journal]


The Use of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine: A Comprehensive Review.

Aesthetic Plast Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Molecular Medicine and Genetics, Research Center for Molecular Medicine, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Introduction: In recent years, platelet-rich plasma (PRP) has emerged as a promising autologous biological treatment modality for the use in aesthetic and regenerative medicine. PRP is a high concentration of platelets derived from whole blood which is isolated by centrifugation to separate and concentrate platelet-containing plasma from red blood cells. PRP comprises hundreds of bioactive proteins, including growth factors, peptides, and cytokines that stimulate healing of skin and soft tissues. Read More

View Article
December 2018
1 Read

Basic chemical peeling-superficial and medium-depth peels.

J Am Acad Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Emory University School of Medicine, Atlanta, GA.

Chemical peeling, or chemexfoliation, has been used for centuries to improve signs of ultraviolet light-induced sun damage. Over the last 30 years, the science behind chemical peeling has evolved, increasing our understanding of the role of peeling ingredients and treatment indications. The depth of peels is directly related to improved results and to the number of complications that can occur. Read More

View Article
December 2018
4 Reads

Advanced chemical peels: phenol-croton oil peel.

J Am Acad Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Emory University School of Medicine, Atlanta, GA.

Once considered the gold standard for deep facial resurfacing, the classical Baker-Gordon phenol-croton oil peel has largely been replaced by formulas with lower concentrations of phenol and croton oil. The improved safety profile of deep peels has ushered in a new era in chemical peeling. Wrinkles can be improved and skin tightened with more subtle and natural results. Read More

View Article
December 2018
2 Reads

Clinical Evaluations of a Novel Thread Lifting Regimen Using Barbed Polyglyconate Suture for Facial Rejuvenation: Analysis Using a 3-Dimensional Imaging System.

Dermatol Surg 2018 Dec 13. Epub 2018 Dec 13.

Oaro Dermatology Clinic, Seoul, Republic of Korea.

Background: Thread lifting with absorbable sutures has recently gained prominence for rejuvenating ptotic and sagging soft tissues in aging face. A barbed, delayed absorbable polyglyconate monofilament shows significantly high tensile loads with superior flexibility and elasticity.

Objective: To evaluate the safety and efficacy of novel thread lifting regimen with barbed polyglyconate suture for counteracting the descent and laxity of the aging face. Read More

View Article
December 2018
2 Reads

Regenerative Capacity of Endogenous Factor: Growth Differentiation Factor 11; a New Approach of the Management of Age-Related Cardiovascular Events.

Int J Mol Sci 2018 Dec 12;19(12). Epub 2018 Dec 12.

Equipe d'Accueil (EA 7460): Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2), Université de Bourgogne-Franche Comté, Faculté des Sciences de Santé, 7 Bd Jeanne d'Arc, 21000 Dijon, France.

Aging is a complicated pathophysiological process accompanied by a wide array of biological adaptations. The physiological deterioration correlates with the reduced regenerative capacity of tissues. The rejuvenation of tissue regeneration in aging organisms has also been observed after heterochronic parabiosis. Read More

View Article
December 2018

Various Rejuvenation Behaviors of Zr-Based Metallic Glass by Cryogenic Cycling Treatment with Different Casting Temperatures.

Nanoscale Res Lett 2018 Dec 6;13(1):398. Epub 2018 Dec 6.

State Key Lab of Materials Processing and Die & Mould Technology, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, 430074, China.

The rejuvenation behavior of an ZrCuAl (at.%) metallic glass upon cryogenic cycling treatment has been investigated. At a high casting temperature, the microstructure of the glass is quite homogenous and thus, internal stress cannot be generated during cycling. Read More

View Article
December 2018

Six years of experience using an advanced algorithm for botulinum toxin application.

J Cosmet Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Albany Medical School, Albany, New York.

Background: Botulinum toxin (BTX) products continue to be widely used for facial rejuvenation. Variables to consider prior to BTX treatment include the anatomical area to be treated, gender, muscle mass, ethnicity, skin thickness, and the effects of aging.

Objective: To describe a treatment algorithm which has been developed for facial rejuvenation to help physicians to easily and systematically customize BTX treatment, and to describe its use in a large number of patients. Read More

View Article
December 2018
2 Reads

Complications in Brow Lifts: A Systemic Review of Surgical and Nonsurgical Brow Rejuvenations.

Plast Reconstr Surg Glob Open 2018 Oct 15;6(10):e1943. Epub 2018 Oct 15.

Dallas Plastic Surgery Institute, Dallas, Tex.

Background: Brow lift has been a part of plastic surgeons' armamentarium for over a century. Although there are multiple different techniques available, there has been a dearth of literature comparing which technique is better and has lesser complications. In this study, we performed a systemic literature review of all brow lift techniques to determine and compare complication rates of each technique. Read More

View Article
October 2018

Comparative (Quantitative and Qualitative) Analysis of Three Different Reagents for Preparation of Platelet-Rich Plasma for Hair Rejuvenation.

Authors:
Sukhbir Singh

J Cutan Aesthet Surg 2018 Jul-Sep;11(3):127-131

Resplendent the cosmetic studio, R-9, GK Part 1, New Delhi-48.

Objective: The aim of this study was to compare the quantity and quality of platelets in platelet-rich plasma (PRP) samples prepared using three different reagents, namely, ethylenediaminetetraacetic acid (EDTA), sodium citrate, and acid citrate dextrose-A (ACD-A) solution.

Materials And Methods: A prospective study was carried out in which all the 50 patients who attended the outpatient department for hair rejuvenation were enrolled for the study. All the patients had a history of hair fall with diffuse thinning of hair, Norwood Grades 2 and 3. Read More

View Article
December 2018

Segmental phenol-Croton oil chemical peels for treatment of periorbital or perioral rhytides.

J Am Acad Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology, Emory University School of Medicine, Atlanta, GA.

View Article
December 2018

Arginase inhibition improves endothelial function in an age-dependent manner in healthy elderly humans.

Rejuvenation Res 2018 Dec 10. Epub 2018 Dec 10.

Karolinska Institutet Department of Medicine Solna, 271345, Cardiology, Stockholm, Sweden ;

Background: Reduced bioavailability of nitric oxide (NO) is accompanied by endothelial dysfunction, which precedes clinical signs of atherosclerosis. The metalloenzyme arginase reciprocally inhibits the formation of NO and available data demonstrate that arginase contributes to reduced bioavailability of NO and increases the formation of reactive oxygen species. Emerging evidence suggest that arginase thereby plays a key role in the pathophysiology of age-associated vascular complications in animal models. Read More

View Article
December 2018

2018: the knee of the rejuvenation curve.

Rejuvenation Res 2018 Dec 6. Epub 2018 Dec 6.

SENS Research Foundation , 110 Pioneer Way, Ste J. , Mountainview, California, United States , 94041.

n/a. Read More

View Article
December 2018
5 Reads

A new approach to lower eyelid-cheek junction rejuvenation.

J Cosmet Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Beijing Lomeye Cosmetic Surgery Clinic, Beijing, China.

Background: Anti-aging in lower eyelid-cheek junction area has always been the upmost widely sought of cosmetic surgery. Removal of orbital fat from inside or outside, removal of part of the skin or even the orbicularis muscle, superficial pull and deep fill and a series of surgical procedures like these have been or are becoming the mainstream of clinical practice. However, aging involves a variety of tissues and causes, which is a dynamic and continuous process. Read More

View Article
December 2018
3 Reads

Late-onset administration of GDF11 extends life span and delays development of age-related markers in the annual fish Nothobranchius guentheri.

Biogerontology 2018 Dec 5. Epub 2018 Dec 5.

Institute of Evolution & Marine Biodiversity and Department of Marine Biology, Ocean University of China, 5 Yushan Road, Qingdao, 266003, China.

Current studies have generated disputes on the age-related change in the concentration of growth differentiation factor 11 (GDF11) and its role in the genesis of rejuvenation conditions. In this study we showed for the first time that both GDF11 gene expression and its protein abundance decreased with age in the fish Nothobranchius guentheri. We also showed that rGDF11 fed was indeed absorbed by the fish. Read More

View Article
December 2018
1 Read

Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice.

Nat Commun 2018 12 5;9(1):5191. Epub 2018 Dec 5.

Department of Orthopaedic Surgery, Duke University, Durham, 27710, USA.

The pace of repair declines with age and, while exposure to a young circulation can rejuvenate fracture repair, the cell types and factors responsible for rejuvenation are unknown. Here we report that young macrophage cells produce factors that promote osteoblast differentiation of old bone marrow stromal cells. Heterochronic parabiosis exploiting young mice in which macrophages can be depleted and fractionated bone marrow transplantation experiments show that young macrophages rejuvenate fracture repair, and old macrophage cells slow healing in young mice. Read More

View Article
December 2018
10.742 Impact Factor

Adipose tissue: A natural resource for multipotent mesenchymal stem cells with potential translation to trigerminal layers.

Indian J Plast Surg 2018 May-Aug;51(2):177-181

Manipal Institute of Regenerative Medicine, Bengaluru, Karnataka, India.

Background: The article reports basic science research that establishes that adipose tissue (AT)-derived mesenchymal stem cells (MSCs) have a potential to transgerminal translation.

Study Design: MSC confirmation was obtained by phenotypic spindle-shaped cells as well as with four positive and three negative markers. The translineage translation of adipose-derived MSCs (ADMSCs) was established. Read More

View Article
December 2018
1 Read

Recombinant manganese peroxidase reduces A2E burden in age related and Stargardt's macular degeneration models.

Rejuvenation Res 2018 Dec 5. Epub 2018 Dec 5.

Ichor Therapeutics, Inc. , 2521 US-11 , Lafayette, New York, United States , 13084 ;

Macular degeneration is hallmarked by retinal accumulation of toxic retinoid species (e.g. A2E) for which there is no endogenous mechanism to eliminate. Read More

View Article
December 2018
3 Reads

Platelet-rich Plasma for Skin Rejuvenation and Treatment of Actinic Elastosis in the Lower Eyelid Area.

Cureus 2018 Jul 18;10(7):e2999. Epub 2018 Jul 18.

Plastic Surgery, Waldkrankenhaus Bonn, Bonn, DEU.

Background Treatment of the lower eyelid region to rejuvenate the skin or treat actinic elastosis often proves difficult. Established treatment options, such as hyaluronic acid injections, botulinum toxin injections, microneedling, skin resurfacing (microdermabrasion, chemical peel (exfoliation), laser treatment), as well as blepharoplasties and autologous fat transfers, can be associated with significant risks and increased patient burden. Furthermore, they may not be effective for treating the signs of skin aging or actinic elastosis, including dark rings under the eyes, a lack of volume and cutis laxa. Read More

View Article
July 2018
6 Reads

Reversibility of irreversible aging.

Ageing Res Rev 2018 Dec 1;49:104-114. Epub 2018 Dec 1.

Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119234, Russia; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Most multicellular organisms are known to age, due to accumulation of damage and other deleterious changes over time. These changes are often irreversible, as organisms, humans included, evolved fully differentiated, irreplaceable cells (e.g. Read More

View Article
December 2018
1 Read

Noninvasive vaginal rejuvenation.

Cutis 2018 Oct;102(4):243-246

Goldenberg Dermatology, PC, New York, USA.

Vaginal rejuvenation procedures are designed to improve the aesthetic appearance and/or function of the female genitalia. The popularity of these techniques continues to increase as more patients seek to reverse the effects of aging, childbearing, and/or hormonal changes. Newer strategies focus on laser and radiofrequency (RF) devices, which have provided noninvasive options for treatment. Read More

View Article
October 2018
1 Read

Cellular senescence as the key intermediate in tau-mediated neurodegeneration.

Rejuvenation Res 2018 Nov 29. Epub 2018 Nov 29.

Panorama Research Institute , 1230 Bordeaux Drive , Sunnyvale, California, United States , 94089 ;

Neuroinflammation is thought to play a key role in progression of neurodegenerative disease such as Alzheimer's disease. Given the apparent nexus of inflammatory disease with the secretory associated senescence phenotype (SASP) of cellular senescence, two reports found that tau-mediated neurodegeneration involves induction of senescence in astrocytes, microglia and possibly even neurons. Elimination of senescent cells by pharmacological induced genetic ablation or by senolytic drugs blocks progression of mutant human tau-mediated neurodegeneration in mice. Read More

View Article
November 2018

Assessing Improvement of Patient Satisfaction Following Facelift Surgery Using the FACE-Q Scales: A Prospective and Multicenter Study.

Aesthetic Plast Surg 2018 Nov 28. Epub 2018 Nov 28.

Department of Plastic and Reconstructive Surgery, Hand Surgery, Burns Unit, FX Michelet Center, University Hospital Bordeaux, Place Amélie Raba-Léon, 33076, Bordeaux, France.

Introduction: Assessment of patient satisfaction following an aesthetic surgery has shown an increasing trend over the past years. To date, there is no prospective and comprehensive study evaluating this aspect after surgical facial and neck rejuvenation. The aim of the current work was to address patient satisfaction after face and neck lift surgery using a validated questionnaire. Read More

View Article
November 2018

From stem cells protection to skin microbiota balance: Orobanche rapum extract, a new natural strategy.

J Cosmet Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Research and Development, Givaudan France SAS, Pomacle, France.

Background: Healthy skin is a delicate balance between skin renewal and microbiota homeostasis, and its imbalance promotes premature aging and dermatological disorders. Skin stem cells are key actors in this process but their sensitivity to aging and external stressors such as UV reduces the skin renewal power. The skin microbiota has been recently described as active in the healthy skin, and its imbalance could trigger some disorders. Read More

View Article
November 2018

Artificial Pigmented Human Skin Created by Muse Cells.

Adv Exp Med Biol 2018 ;1103:255-271

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

The skin composes physiological and chemical barrier and renews skin component cells throughout the human life. Melanocytes locate in the basal layer of the epidermis and produce melanin to protect the skin from ultraviolet. Melanin plays key roles in determining human skin and hair color. Read More

View Article
January 2018

Molecular Factors of the Maintenance and Activation of the Juvenile Phenotype of Cellular Sources for Eye Tissue Regeneration.

Authors:
E N Grigoryan

Biochemistry (Mosc) 2018 Nov;83(11):1318-1331

Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 119334, Russia.

Modern achievements in the understanding of tissue regeneration, identification of endogenous cell sources for regeneration, and development of approaches for induction and differentiation of pluripotent stem cells have open broad prospects for regenerative medicine. However, application of the obtained information in medicine is hindered by insufficient knowledge on the molecular factors and their combinations capable of regulating the age and fate of cellular sources for eye tissue reparation as well as on the regenerative responses of these cells. In the review, we present our own and literature data on cells serving as endogenous sources for eye tissue regeneration in lower and higher vertebrates and properties of gene expression that allow these cells to maintain their juvenile phenotype. Read More

View Article
November 2018

Clinical Evaluation of Safety and Efficacy of Fractional Radiofrequency Facial Treatment of Skin Type VI Patients

J Drugs Dermatol 2018 Nov;17(11):1169 - 1172

INTRODUCTION: It has been well established that patients with darker skin types (Fitzpatrick skin types IV-VI) have an increased incidence of thermal induced side effects from laser and radio frequency (RF) treatments. Complications include a higher risk of post-inflammatory hyperpigmentation, hypopigmentation, and scarring, leading to unsatisfactory clinical outcomes. Fractional technologies improve the safety when treating patients with skin of color by treating only fractions of the skin while leaving a healing reservoir of untreated skin that improves the healing process. Read More

View Article
November 2018
3 Reads

Commentary on Some Recent Theses Relevant to Combating Aging: December 2018.

Rejuvenation Res 2018 Nov 27. Epub 2018 Nov 27.

SENS Research Foundation , 110 Pioneer Way, Ste J. , Mountainview, California, United States , 94041.

Theses reviewed in this issue include "A Thromboresistant Cell-Derived Biomaterial Modification for Vascular Grafts", "Actomyosin mediated tension orchestrates thermogenic programs in adipocytes", "Age-Associated Changes in Intrathymic B Cell Population in Mice", "Endoplasmic Reticulum Stress is Transmissible among Cells of the Central Nervous System", "Evaluation of Early Tumor Angiogenesis Using Ultrasound Acoustic Angiography", and "Interactions Between Amyloid-Beta and Microglial Cells". Read More

View Article
November 2018

A Case Report of Scrotal Rejuvenation: Laser Treatment of Angiokeratomas of the Scrotum.

Authors:
Philip R Cohen

Dermatol Ther (Heidelb) 2018 Nov 26. Epub 2018 Nov 26.

San Diego Family Dermatology, National City, CA, USA.

Scrotal rejuvenation encompasses not only the functional quality but also the aesthetic appearance of the scrotum. It includes medical therapy and procedural interventions to improve scrotal conditions that require morphologic restoration and/or aesthetic alteration. Rejuvenation of the scrotum may be appropriate for aging-related and non-aging-related changes concerning the hair (alopecia and hypertrichosis), the morphology (laxity and wrinkles), and/or the vascularity (angiokeratoma) of the scrotum. Read More

View Article
November 2018
4 Reads

Vaginal rejuvenation: whose turf?

Semin Cutan Med Surg 2018 Dec;37(4):236-237

Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Many medical conditions can cross over the territories of various specialties. These conditions may benefit from, or even require, a multidisciplinary approach. While ideally this leads to a collaborative and coveted patient-centered care model, it can also give rise to competitive turf wars. Read More

View Article
December 2018
1 Read

Rejuvenation of β cells by epigenetic editing.

J Clin Invest 2018 Nov 26. Epub 2018 Nov 26.

Guangzhou Institutes of Biomedicine and Health.

Insulin-secreting β cell loss or dysfunction is a feature of both type 1 and type 2 diabetes. Strategies to restore β cell mass are limited, as sources of healthy islets are scarce and mature β cells are not readily expanded in vitro. In this issue of the JCI, Ou et al. Read More

View Article
November 2018
5 Reads

T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses.

Front Immunol 2018 9;9:2569. Epub 2018 Nov 9.

Division of Infection Biology and Medical Microbiology, Department of Life Sciences, School of Life Sciences, Central University of Tamil Nadu, Thiruvarur, India.

T-cell exhaustion is a phenomenon of dysfunction or physical elimination of antigen-specific T cells reported in human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infections as well as cancer. Exhaustion appears to be often restricted to CD8+ T cells responses in the literature, although CD4+ T cells have also been reported to be functionally exhausted in certain chronic infections. Although our understanding of the molecular mechanisms associated with the transcriptional regulation of T-cell exhaustion is advancing, it is imperative to also explore the central mechanisms that control the altered expression patterns. Read More

View Article
November 2018
1 Read

What's New in Cosmetic Dermatology.

Dermatol Clin 2019 Jan;37(1):117-128

Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA; Dermatologic SurgiCenter, 1200 Locust Street, Philadelphia, PA 19107, USA. Electronic address:

Topical silicone gel is more beneficial than petrolatum-based products as an all-purpose wound dressing for granulating and sutured wounds, regardless of cause. Vaginal laser rejuvenation is effective in relieving genitourinary syndrome of menopause, stress urinary incontinence, vaginal relaxation syndrome, and related vulvar disorders. New cosmetic indications in the upper face for onabotulinumtoxinA have been approved by the Food and Drug Administration, whereas off-label treatments in the lower face increase in popularity. Read More

View Article
January 2019
6 Reads

Assessment of bioavailability of gold bhasma in human participants - A pilot study.

J Ayurveda Integr Med 2018 Nov 17. Epub 2018 Nov 17.

Ayurveda Chair, University of Debrecen, Debrecen, 4032, Hungary.

Bioavailability of the well-known Ayurvedic drug Swarnabhasma (gold bhasma or calcined gold) is unknown. It is orally administered either sublingually or directly with various Anupanas like black pepper powder (Piper nigrum Linn.) and cow ghee in the dose range of 15-240 mg by Ayurvedic physicians. Read More

View Article
November 2018
1 Read

Glycolytic inhibitor 2-deoxy-D-glucose at chronic low dose mimics calorie restriction in rats through mitohormetic induction of ROS.

Rejuvenation Res 2018 Nov 18. Epub 2018 Nov 18.

University of Allahabad, Department of Biochemistry , faculty of Science , Allahabad, Uttar Pradesh, India , 211002.

Caloric restriction mimetics (CRMs) provide an exciting anti-aging intervention strategy. 2-deoxy-D-glucose (2-DG), a glycolytic inhibitor is known to works as a CRM at high doses, however chronic high dose has been linked to increased mortality in rats. We have investigated chronic low dose dietary administration of 2-DG on age-related stress protection in young and old age male wistar rats by evaluating age-dependent biomarkers in plasma and erythrocytes. Read More

View Article
November 2018
4 Reads

Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity.

Aging Cell 2018 Nov 18:e12877. Epub 2018 Nov 18.

MRC Human Genetics Unit, MRC, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

Induced pluripotent stem cells (IPSCs), with their unlimited regenerative capacity, carry the promise for tissue replacement to counter age-related decline. However, attempts to realize in vivo iPSC have invariably resulted in the formation of teratomas. Partial reprogramming in prematurely aged mice has shown promising results in alleviating age-related symptoms without teratoma formation. Read More

View Article
November 2018

Autologous platelet-rich gel for facial rejuvenation and wrinkle amelioration: A pilot study.

J Cosmet Dermatol 2018 Nov 18. Epub 2018 Nov 18.

Hospital Universitario Ramón y Cajal, Madrid, Spain.

Background: The demand for safe and minimally invasive soft tissue augmentation procedures has increased. Recently, a novel injectable gel based on the autologous platelet rich in growth factor (PRGF) technology has been developed to provide long-term shape and volume stability. It can be customized into low (LVG) or high viscosity (HVG) gel forms to meet different dermatological requirements. Read More

View Article
November 2018
9 Reads

Q-switched 1064-nm dymium-doped yttrium aluminum garnet laser irradiation induces skin collagen synthesis by stimulating MAPKs pathway.

Lasers Med Sci 2018 Nov 17. Epub 2018 Nov 17.

Department of Dermatology, The first affiliated hospital of Kunming medical University, No. 295, Xichang Road, Kunming, 650032, Yunnan, China.

The 1064-nm Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser is widely used in clinical practice. However, the effects of 1064-nm Q-switched Nd:YAG laser on skin collagen generation have not been fully elucidated. The objectives of the present study were to investigate whether the 1064-nm Q-switched Nd:YAG laser can be used for non-ablative rejuvenation and to explore the possible mechanism underlying the effects. Read More

View Article
November 2018
1 Read

Face and Neck Lifting After Weight Loss.

Clin Plast Surg 2019 Jan 23;46(1):105-114. Epub 2018 Oct 23.

Department of Plastic Surgery, Dermatology and Plastic Surgery Institute, Cleveland Clinic, 9500 Euclid Avenue, A60, Cleveland, OH 44195, USA.

After massive weight loss, deflation of the tissues and loss of skin elasticity in the face and neck can result in the appearance of accelerated facial aging. Surgical facial rejuvenation can be successfully performed with several modifications. Proper preoperative counseling and expectation management regarding staged or ancillary procedures is recommended. Read More

View Article
January 2019
13 Reads

Aminoglycoside Revival: Review of a Historically Important Class of Antimicrobials Undergoing Rejuvenation.

EcoSal Plus 2018 11;8(1)

Achaogen Inc., South San Francisco, CA 94080.

Aminoglycosides are cidal inhibitors of bacterial protein synthesis that have been utilized for the treatment of serious bacterial infections for almost 80 years. There have been approximately 15 members of this class approved worldwide for the treatment of a variety of infections, many serious and life threatening. While aminoglycoside use declined due to the introduction of other antibiotic classes such as cephalosporins, fluoroquinolones, and carbapenems, there has been a resurgence of interest in the class as multidrug-resistant pathogens have spread globally. Read More

View Article
November 2018
2 Reads

Combination of grid laser photocoagulation and a single intravitreal ranibizumab as an efficient and cost-effective treatment option for macular edema secondary to branch retinal vein occlusion.

Rejuvenation Res 2018 Nov 16. Epub 2018 Nov 16.

Shanghai University of Medicine and Health Sciences, 191610, Department of Clinical and Basic Sciences, Shanghai, Shanghai, China.

Purpose Our prospective, comparative study of 60 patients aimed to compare the efficacy and feasibility of a single injection ranibizumab vs a single grid laser photocoagulation and vs. a combined treatment in macular edema secondary to branch retinal vein occlusion in Asian population. Methods Patients were randomized 1:1:1 (n=20/group) into laser (LAS), the ranibizumab (RAN) and the combination (COM) group. Read More

View Article
November 2018

Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates.

Aging Cell 2018 Nov 14:e12865. Epub 2018 Nov 14.

Department of Immunobiology, University of Arizona College of Medicine-Tucson, Tucson, Arizona.

In youth, thymic involution curtails production of new naïve T cells, placing the onus of T-cell maintenance upon secondary lymphoid organs (SLO). This peripheral maintenance preserves the size of the T-cell pool for much of the lifespan, but wanes in the last third of life, leading to a dearth of naïve T cells in blood and SLO, and contributing to suboptimal immune defense. Both keratinocyte growth factor (KGF) and sex steroid ablation (SSA) have been shown to transiently increase the size and cellularity of the old thymus. Read More

View Article
November 2018
7 Reads

A whole lifespan mouse multi-tissue DNA methylation clock.

Elife 2018 11 14;7. Epub 2018 Nov 14.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.

Age predictors based on DNA methylation levels at a small set of CpG sites, DNAm clocks, have been developed for humans and extended to several other species. Three currently available versions of mouse DNAm clocks were either created for individual tissues or tuned toward young ages. Here, we constructed a robust multi-tissue age predictor based on 435 CpG sites, which covers the entire mouse lifespan and remains unbiased with respect to any particular age group. Read More

View Article
November 2018
8 Reads

Sudden Events Change Old Visual Objects Into New Ones: A Possible Role for Phasic Activation of Locus Coeruleus.

Psychol Sci 2018 Nov 14:956797618807190. Epub 2018 Nov 14.

3 Department of Psychology, Simon Fraser University.

We report a novel visual phenomenon called the rejuvenation effect. It causes an "old" object that has been on view for some time to acquire the properties of a suddenly appearing new object. In each experiment, a square outline was displayed continuously on one side of fixation. Read More

View Article
November 2018
1 Read

Liquid Metal Enabled Electrobiology: A New Frontier to Tackle Disease Challenges.

Micromachines (Basel) 2018 Jul 21;9(7). Epub 2018 Jul 21.

Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.

In this article, a new conceptual biomedical engineering strategy to tackle modern disease challenges, called liquid metal (LM) enabled electrobiology, is proposed. This generalized and simple method is based on the physiological fact that specially administrated electricity induces a series of subsequent desired biological effects, either shortly, transitionally, or permanently. Due to high compliance within biological tissues, LM would help mold a pervasive method for treating physiological or psychological diseases. Read More

View Article
July 2018
3 Reads

Effect of Platelet-Rich Plasma Injection for Rejuvenation of Photoaged Facial Skin: A Randomized Clinical Trial.

JAMA Dermatol 2018 Dec;154(12):1447-1452

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Importance: There remains little experimental evidence and no randomized clinical trial to date to confirm the benefit of platelet-rich plasma (PRP) for facial rejuvenation.

Objective: To investigate whether PRP injection improves the visual appearance, including texture and color, of photodamaged facial skin.

Design, Setting, And Participants: In this randomized clinical trial, participants and raters were masked to groupings. Read More

View Article
December 2018
14 Reads

A Novel Extended Deep Plane Facelift Technique for Jawline Rejuvenation and Volumization.

Aesthet Surg J 2018 Nov 12. Epub 2018 Nov 12.

Department of Otolaryngology, Head and Neck Surgery, Albert Einstein College of Medicine, New York, NY.

Background: Jawline aging is a complex process. We believe loss of posterior jawline definition and volume depletion is an underappreciated factor in the aging face.

Objectives: The aim of this study is to describe a novel composite, rotational flap modification of an extended deep-plane rhytidectomy. Read More

View Article
November 2018
14 Reads

Periauricular Purse-String Reinforced with SMAS plication and Malaria Fat Pad Elevation for Mid-and Lower Facial Rejuvenation: FACE-Q Report.

Ann Plast Surg 2018 Dec;81(6S Suppl 1):S59-S65

From the Department of Plastic Surgery, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, People's Republic of China.

Background: Facial aging is a complex process influencing every layer of the facial structure. Most accepted surgical techniques for facial rejuvenation involve certain manipulation of the superficial musculoaponeurotic system (SMAS). Out of these SMAS-based techniques, SMAS plication or suspension provides excellent outcomes with shorter convalescence and fewer potential complications. Read More

View Article
December 2018
14 Reads

Conditioned media from human umbilical cord blood-derived mesenchymal stem cells stimulate rejuvenation function in human skin.

Biochem Biophys Rep 2018 Dec 25;16:96-102. Epub 2018 Oct 25.

Stem Cells and Regenerative Bioengineering Institute, Kangstem Biotech Co., Ltd., 2nd floor, Biotechnology center, #81 Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.

Developing treatments that inhibit skin aging is an important research project. Rejuvenation, which focuses on prevention of skin aging, is one of the major issues. Recent studies suggested that mesenchymal stem cells (MSCs) secrete many cytokines, which are important in wound healing. Read More

View Article
December 2018
3 Reads

TREK-2 mediates the neuroprotective effect of isoflurane preconditioning against acute cerebral ischemia in the rat.

Rejuvenation Res 2018 Nov 9. Epub 2018 Nov 9.

Xijing Hospital, 66352, Anesthesiology , 127 Changle West Road , Xian, China , 710032 ;

It is known that preconditional treatment with volatile anesthetics can induce tolerance of the brain to stroke. A previous study demonstrated that the involvement of TREK-1, a two-pore domain K+ channel, in sevoflurane preconditioning-induced neuroprotection against focal cerebral ischemia in rats. The present study testified whether TREK-2, another anesthetics-target K+ channels, is also associated with volatile anesthetics-induced neuroprotection, and further explored its potential mechanism. Read More

View Article
November 2018
8 Reads

Metabolomics study on the effects of salvianolic acid B and borneol for treating cerebral ischemia in rats by UPLC-Q/TOF-MS.

Rejuvenation Res 2018 Nov 9. Epub 2018 Nov 9.

Department of cardiology, Xi'an No.1 HospitalXi'an, China , 710000 ;

Salviae miltiorrliza-borneol Jun-Shi coupled-herbs have been widely used for treatment of ischemia stroke. Salvianolic acid B was the most abundant and bioactive compound of Salviae miltiorrliza and used for prevention and treatment of cerebrovascular diseases. However, the scientific intension and compatible mechanism of Salvianolic acid B - borneol combination were still unknown. Read More

View Article
November 2018
9 Reads