1,165 results match your criteria Rejuvenation Research [Journal]


Effects of Guilingji on aging rats and its underlying mechanisms.

Rejuvenation Res 2019 Apr 15. Epub 2019 Apr 15.

Shanxi University, 12441, Modern Research Center for Traditional Chinese Medicine, Taiyuan, Shanxi , China ;

Guilingji (GLJ), a traditional Chinese medicine, is of wide concern because of its remarkable anti-aging effect with a long application history. It mainly consists of traditional Chinese herbs i.e. Read More

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http://dx.doi.org/10.1089/rej.2018.2118DOI Listing

Commentary on Some Recent Theses Relevant to Combating Aging: April 2019.

Rejuvenation Res 2019 Apr;22(2):175-180

Theses reviewed in this issue include "Alpha-Synuclein Oligomers: Cellular Mechanisms and Aspects of Antibody Treatment," "Cx3cr1/cx3cl1 Axis Drives the Migration and Maturation of Oligodendroglia in the Central Nervous System," "Genome-Wide Expression Profiling of Human Circulating Monocytes and Macrophages Identifies Diagnostic and Prognostic Signatures for Cancer Outcomes," "Lysosomal Oxidation of Low Density Lipoproteins," and "The Senescence-Associated Secretory Phenotype Induced by ID1-p16 Axis Contributes to Sorafenib Resistance in Hepatocellular Carcinoma." Read More

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http://dx.doi.org/10.1089/rej.2019.2201DOI Listing
April 2019
1 Read

The Essential Role of Philanthropy in the Increasingly Investable Rejuvenation Sector.

Rejuvenation Res 2019 Apr;22(2):97-98

SENS Research Foundation, Mountain View, California.

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http://dx.doi.org/10.1089/rej.2019.2198DOI Listing

Regulation of S-Nitrosylation in Aging and Senescence.

Rejuvenation Res 2019 Apr;22(2):171-174

1 Panorama Research Institute, Sunnyvale, California.

Nitric oxide signals through several distinct mechanisms, including interaction with the heme group of guanylyl cyclase enzymes resulting in modulation of cGMP levels in the vascular endothelium. Alternatively, reactive nitrogen oxide species can bind cysteine residues in target proteins forming S-nitrosothiols. S-nitrosylation is recognized as an important post-translational modification of dozens of proteins, which plays a key role in cellular homeostasis, metabolism, and various disease states. Read More

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https://www.liebertpub.com/doi/10.1089/rej.2019.2194
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http://dx.doi.org/10.1089/rej.2019.2194DOI Listing
April 2019
2 Reads

Cystathionine β-Synthase-Derived Hydrogen Sulfide Correlates with Successful Aging in Mice.

Rejuvenation Res 2019 Mar 29. Epub 2019 Mar 29.

3 Department of Anesthesiology, and the Second Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi, China.

Although learning and memory decline are associated with aging, some older individuals show high cognitive function. The mechanism underlying successful aging is not clear, although augmented N-methyl-D-aspartate receptor-independent long-term depression (LTD) has been found in successfully aged rats. We hypothesized that metabotropic glutamate receptor dependent LTD (mGluR-LTD) is associated with successful aging in mice and explored its molecular mechanisms. Read More

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http://dx.doi.org/10.1089/rej.2018.2166DOI Listing
March 2019
3.311 Impact Factor

Meetings Calendar 2019.

Authors:

Rejuvenation Res 2019 Feb;22(1):89-96

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http://dx.doi.org/10.1089/rej.2019.2176DOI Listing
February 2019
1 Read

Proteomic Analysis of Hydroxysafflor Yellow A Against Cerebral Ischemia/Reperfusion Injury in Rats.

Rejuvenation Res 2019 Mar 19. Epub 2019 Mar 19.

1 Department of Pharmacy, Xijing Hospital, the Fourth Military Medical University, Xi'an, China.

Hydroxysafflor yellow A (HSYA), an active component from Chinese medicinal herb, has been applied to the prevention and treatment of cerebral ischemia/reperfusion injury (CIRI). To clarify the comprehensive mechanisms HSYA for stroke, we used label-free quantitative proteomic analysis to investigate the modulated proteins of rats subjected to CIRI and their alteration by HSYA. Neurological examination, infarct assessment, and biochemical assay were performed to validate the effects of HSYA, and the results indicated that HSYA played a significant role in brain protection. Read More

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http://dx.doi.org/10.1089/rej.2018.2145DOI Listing
March 2019
3 Reads

Application of Circulation Tumor Cells Detection in Diagnosis and Treatment of Breast Tumors.

Rejuvenation Res 2019 Mar 22. Epub 2019 Mar 22.

2 Shanghai University of Medicine and Health Sciences, Shanghai, P.R. China.

In recent years, the clinical application of circulating tumor cell (CTCs) detection has become one of the research hotspots in the field of precision medicine. CTCs detection is noninvasive, easy to obtain, can be repeatedly collected, and highly repeatable with other advantages. It not only can be a real-time comprehensive monitoring of cancer treatment but also can have a large number of applications, including early diagnosis of tumor, timely evaluation of efficacy, condition monitoring, resistance factor analysis, prognosis judgment, individualized treatment of tumors, drug guidance, and so on. Read More

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http://dx.doi.org/10.1089/rej.2018.2154DOI Listing
March 2019
1 Read

Validated Living Worldwide Supercentenarians 112+, Living and Recently Deceased: February 2019.

Rejuvenation Res 2019 Feb;22(1):79-81

1 Gerontology Research Group, Sandy Springs, Georgia.

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http://dx.doi.org/10.1089/rej.2019.2179DOI Listing
February 2019

Evidence That Jeanne Calment Died in 1934-Not 1997.

Authors:
Nikolay Zak

Rejuvenation Res 2019 Feb;22(1):3-12

Moscow Society of Naturalists, Moscow, Russia.

I present a body of data that, I argue, cumulatively casts serious doubt on the validity of Jeanne Calment's accepted world record of human life span. First, I assess the plausibility of the record based on the life spans of other centenarians in the International Database of Longevity (IDL) and critique some arguments put forward previously in support of that plausibility, including the longevity of Calment's ancestors. Second, I review the literature dedicated to Calment and discuss multiple contradictions in her interviews, biographies, photos, and documents. Read More

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http://dx.doi.org/10.1089/rej.2018.2167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424156PMC
February 2019
1 Read

Cherish Your Exceptions, But Also Your Doubts.

Rejuvenation Res 2019 Feb;22(1):1-2

SENS Research Foundation, Mountain View, California.

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http://dx.doi.org/10.1089/rej.2019.2178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424154PMC
February 2019
1 Read

Frailty and Rejuvenation with Stem Cells: Therapeutic Opportunities and Clinical Challenges.

Rejuvenation Res 2019 Mar 21. Epub 2019 Mar 21.

1 National Clinical Research Center of Geriatrics, West China Hospital, Sichuan University, Chengdu, China.

Frailty, one appealing target for improving successful aging of the elderly population, is a common clinical syndrome based on the accumulation of multisystemic function declines and the increase in susceptibility to stressors during biological aging. The age-dependent senescence, the frailty-related stem cell depletion, chronic inflammation, imbalance of immune homeostasis, and the reduction of multipotent stem cells collectively suggest the rational hypothesis that it is possible to (partially) cure frailty with stem cells. This systematic review has included all of the human trials of stem cell therapy for frailty from the main electronic databases and printed materials and screened the closely related reviews themed on the mechanisms of aging, frailty, and stem cells, to provide more insights in stem cell strategies for frailty, one promising method to recover health from a frail status. Read More

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http://dx.doi.org/10.1089/rej.2017.2048DOI Listing
March 2019
20 Reads
3.311 Impact Factor

Commentary on Some Recent Theses Relevant to Combating Aging: February 2019.

Rejuvenation Res 2019 Feb;22(1):82-88

Theses reviewed in this issue include Characterization and Modeling of Metabolic Stress Responses in Cellular Aging; Engineering Immunity: Enhancing T Cell Vaccines and Combination Immunotherapies for the Treatment of Cancer; Extracellular Inflammatory Signaling from Dysfunctional Telomeres; High-Throughput Microfluidic Labyrinth for the Label-Free Isolation of circulating tumor cells for Single-Cell Gene Expression Profiling; Oxygen Nanobubbles for Ultrasound-guided Targeting of Cancer Hypoxia; and The Eye as a Window to the Alzheimer's Disease Brain. Read More

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https://www.liebertpub.com/doi/10.1089/rej.2019.2177
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http://dx.doi.org/10.1089/rej.2019.2177DOI Listing
February 2019
6 Reads

Incompatibility Mechanism Between Radix Paeoniae Alba and Veratrum nigrum Focusing on Estrogen-Estrogen Receptor Pathway in Immature/Ovariectomized Mice.

Rejuvenation Res 2019 Mar 5. Epub 2019 Mar 5.

1 Department of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.

Radix paeoniae alba (RPA) and Veratrum nigrum (VN) L. belong to the 18 incompatible medicaments and have been prohibited for thousands of years in China. Previous studies focused on the chemical constituents that induced the toxicological response of the two agents, but this study offers preliminary insight into the pharmacodynamics and mechanism on estrogenic activity, which is responsible for their incompatibility. Read More

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http://dx.doi.org/10.1089/rej.2017.2026DOI Listing
March 2019
3 Reads

Body Composition and S-Klotho Plasma Levels in Middle-Aged Adults: A Cross-Sectional Study.

Rejuvenation Res 2019 Mar 1. Epub 2019 Mar 1.

1 EFFECTS-262 Research Group, Department of Physiology, School of Medicine, University of Granada, Granada, Spain.

The α-Klotho gene was identified as a possible "aging-suppressor" agent that extends life span when overexpressed. However, little is known about the association of the body composition with the secreted protein form of the α-Klotho gene (S-Klotho). Therefore, the aim of this study was to analyze the association of body composition, including lean and fat mass as well as bone mineral density (BMD), with S-Klotho plasma levels in middle-aged sedentary adults. Read More

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http://dx.doi.org/10.1089/rej.2018.2092DOI Listing
March 2019
1 Read

Serum Levels of Protein-Bound Methylglyoxal-Derived Hydroimidazolone-1 are Independently Correlated with Asymmetric Dimethylarginine.

Rejuvenation Res 2019 Mar 28. Epub 2019 Mar 28.

3 Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan.

Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase, being involved in endothelial dysfunction. Furthermore, ADMA levels have been shown to predict future cardiovascular events in patients with coronary risk factors, such as diabetes and hypertension. We have previously found that glyceraldehyde-derived advanced glycation end products (glycer-AGEs) stimulate ADMA generation in vitro and the levels are associated with ADMA, endothelial dysfunction, and vascular inflammation in humans. Read More

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http://dx.doi.org/10.1089/rej.2018.2152DOI Listing
March 2019
3 Reads

The Role and Mechanism of miRNA-1224 in the Polygonatum sibiricum Polysaccharide Regulation of Bone Marrow-Derived Macrophages to Osteoclast Differentiation.

Rejuvenation Res 2019 Mar 15. Epub 2019 Mar 15.

1 Department of Nutrition and Food Hygiene, College of Public Hygiene of Guangxi Medical University, Nanning, Guangxi, China.

MicroRNAs (miRNAs) are endogenous noncoding small molecule RNAs that regulate cell proliferation, differentiation, fat metabolism, and hormone secretion. Studies have shown that miRNAs regulate the processes related to osteoporosis, including the differentiation of osteoblasts, osteoclasts, and chondrocytes, and are one of the important regulatory factors of some bone metabolic diseases. In our previous study, it has been revealed that natural compound Polygonatum sibiricum polysaccharide (PSP) can promote osteoblast formation and block osteoclastogenesis through Wnt/β-catenin signaling pathway. Read More

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http://dx.doi.org/10.1089/rej.2018.2126DOI Listing
March 2019
2 Reads

Integration of Melatonin Related Redox Homeostasis, Aging, and Circadian Rhythm.

Rejuvenation Res 2019 Feb 4. Epub 2019 Feb 4.

Department of Medical Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Circadian rhythms (CRs) are intrinsic clocks organizing the behavior and physiology of organisms. These clocks are thought to have coevolved with cellular redox regulation. Metabolism, redox homeostasis, circadian clock, and diet offer insights into aging. Read More

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https://www.liebertpub.com/doi/10.1089/rej.2018.2159
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http://dx.doi.org/10.1089/rej.2018.2159DOI Listing
February 2019
3 Reads
3.311 Impact Factor

Red Blood Cell Distribution Width, Vascular Aging Biomarkers, and Endothelial Progenitor Cells for Predicting Vascular Aging and Diagnosing/Prognosing Age-Related Degenerative Arterial Diseases.

Rejuvenation Res 2019 Feb 11. Epub 2019 Feb 11.

2 Department of Cardiac Surgery, University of Rome "Tor Vergata," Rome, Italy.

The emerging evidence emphasizes Red blood cell distribution width (RDW) as optimal prognostic biomarker for cardiovascular diseases. However, several clinical biases impede its clinical application. Recent recommendations suggest combining RDW with other biomarkers. Read More

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https://www.liebertpub.com/doi/10.1089/rej.2018.2144
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http://dx.doi.org/10.1089/rej.2018.2144DOI Listing
February 2019
11 Reads

The Relationship Between Sleep Duration, Falls, and Muscle Mass: A Cohort Study in an Elderly Chinese Population.

Rejuvenation Res 2019 Jan 24. Epub 2019 Jan 24.

1 Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University , Tianjin, China .

Epidemiological studies report that more than half of the people over the age of 65 years suffer from variable sleep problems. In this study, we conducted a cohort study to investigate the relationship between sleep duration, muscle mass, and function within a community-dwelling, elderly Chinese population. Our study population consisted of residents living in the township central hospital of suburban Tianjin, China. Read More

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http://dx.doi.org/10.1089/rej.2018.2102DOI Listing
January 2019
7 Reads

Arginase Inhibition Improves Endothelial Function in an Age-Dependent Manner in Healthy Elderly Humans.

Rejuvenation Res 2019 Jan 24. Epub 2019 Jan 24.

Division of Cardiology, Department of Medicine, Karolinska Institutet, Heart and Vascular Theme, Karolinska University Hospital , Stockholm, Sweden .

Reduced bioavailability of nitric oxide (NO) is accompanied by endothelial dysfunction, which precedes clinical signs of atherosclerosis. The metalloenzyme arginase reciprocally inhibits the formation of NO and available data demonstrate that arginase contributes to reduced bioavailability of NO and increases the formation of reactive oxygen species. Emerging evidence suggests that arginase thereby plays a key role in the pathophysiology of age-associated vascular complications in animal models. Read More

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http://dx.doi.org/10.1089/rej.2018.2135DOI Listing
January 2019
2 Reads

2018: The Knee of the Rejuvenation Curve.

Rejuvenation Res 2018 12;21(6):495-496

SENS Research Foundation, Mountain View, California.

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https://www.liebertpub.com/doi/10.1089/rej.2018.2163
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http://dx.doi.org/10.1089/rej.2018.2163DOI Listing
December 2018
17 Reads

Recombinant Manganese Peroxidase Reduces A2E Burden in Age-Related and Stargardt's Macular Degeneration Models.

Rejuvenation Res 2018 Dec;21(6):560-571

1 Ichor Therapeutics, Inc., Lafayette, New York.

Macular degeneration is hallmarked by retinal accumulation of toxic retinoid species (e.g., A2E) for which there is no endogenous mechanism to eliminate it. Read More

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http://dx.doi.org/10.1089/rej.2018.2146DOI Listing
December 2018
17 Reads

Cellular Senescence as the Key Intermediate in Tau-Mediated Neurodegeneration.

Rejuvenation Res 2018 Dec;21(6):572-579

1 Panorama Research Institute, Sunnyvale, California.

Neuroinflammation is thought to play a key role in the progression of neurodegenerative disease such as Alzheimer's disease (AD). Given the apparent nexus of inflammatory disease with the secretory-associated senescence phenotype (SASP) of cellular senescence, two reports found that tau-mediated neurodegeneration involves induction of senescence in astrocytes, microglia, and possibly even neurons. Elimination of senescent cells by pharmacologically induced genetic ablation or by senolytic drugs blocks progression of mutant human tau-mediated neurodegeneration in mice. Read More

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https://www.liebertpub.com/doi/10.1089/rej.2018.2155
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http://dx.doi.org/10.1089/rej.2018.2155DOI Listing
December 2018
8 Reads

Commentary on Some Recent Theses Relevant to Combating Aging: December 2018.

Rejuvenation Res 2018 Dec;21(6):580-586

Theses reviewed in this issue include "A Thromboresistant Cell-Derived Biomaterial Modification for Vascular Grafts," "Actomyosin Mediated Tension Orchestrates Thermogenic Programs in Adipocytes," "Age-Associated Changes in Intrathymic B Cell Population in Mice," "Endoplasmic Reticulum Stress Is Transmissible Among Cells of the Central Nervous System," "Evaluation of Early Tumor Angiogenesis Using Ultrasound Acoustic Angiography," and "Interactions Between Amyloid-Beta and Microglial Cells." Read More

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http://dx.doi.org/10.1089/rej.2018.2156DOI Listing
December 2018
1 Read

Glycolytic Inhibitor 2-Deoxy-D-Glucose at Chronic Low Dose Mimics Calorie Restriction in Rats Through Mitohormetic Induction of Reactive Oxygen Species.

Rejuvenation Res 2019 Jan 9. Epub 2019 Jan 9.

Department of Biochemistry, University of Allahabad, Allahabad, India.

Caloric restriction mimetics (CRMs) provide an exciting antiaging intervention strategy. 2-Deoxy-D-glucose (2-DG), a glycolytic inhibitor, is known to work as a CRM at high doses; however, at chronic high dose it has been linked to increased mortality in rats. We have investigated chronic low-dose dietary administration of 2-DG on age-related stress protection in young and old male Wistar rats by evaluating age-dependent biomarkers in plasma and erythrocytes. Read More

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https://www.liebertpub.com/doi/10.1089/rej.2018.2125
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http://dx.doi.org/10.1089/rej.2018.2125DOI Listing
January 2019
17 Reads

Combination of Grid Laser Photocoagulation and a Single Intravitreal Ranibizumab as an Efficient and Cost-Effective Treatment Option for Macular Edema Secondary to Branch Retinal Vein Occlusion.

Rejuvenation Res 2019 Mar 15. Epub 2019 Mar 15.

3 College of Basic Medical Studies, Shanghai University of Medicine and Health Sciences, Shanghai, PR China.

Our prospective comparative study of 60 patients aimed to compare the efficacy and feasibility of a single injection ranibizumab versus a single grid laser photocoagulation and versus a combined treatment in macular edema secondary to branch retinal vein occlusion in Asian population. Patients were randomized 1:1:1 (n = 20/group) into grid laser (LAS), the ranibizumab (RAN), and the combination (COM) group. Outcomes were measured as best-corrected visual acuity (BCVA) and central macular thickness (CMT). Read More

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http://dx.doi.org/10.1089/rej.2018.2141DOI Listing
March 2019
1 Read

TREK-2 Mediates the Neuroprotective Effect of Isoflurane Preconditioning Against Acute Cerebral Ischemia in the Rat.

Rejuvenation Res 2018 Dec 28. Epub 2018 Dec 28.

1 Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

It is known that preconditional treatment with volatile anesthetics can induce tolerance of the brain to stroke. A previous study demonstrated that the involvement of TREK-1, a two-pore domain K+ channel, in sevoflurane preconditioning induced neuroprotection against focal cerebral ischemia in rats. The present study testified whether TREK-2, another anesthetic-target K+ channel, is also associated with volatile anesthetic-induced neuroprotection, and further explored its potential mechanism. Read More

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https://www.liebertpub.com/doi/10.1089/rej.2017.2039
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http://dx.doi.org/10.1089/rej.2017.2039DOI Listing
December 2018
17 Reads

Metabolomics Study on the Effects of Salvianolic Acid B and Borneol for Treating Cerebral Ischemia in Rats by Ultra-Performance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry.

Rejuvenation Res 2018 Dec 28. Epub 2018 Dec 28.

1 Department of Cardiology, Xi'an No.1 Hospital, Xi'an, China.

Salviae miltiorrliza-borneol Jun-Shi coupled-herbs have been widely used for treatment of ischemia stroke. Salvianolic acid B was the most abundant and bioactive compound of Salviae miltiorrliza and used for prevention and treatment of cerebrovascular diseases. However, the scientific intension and compatible mechanism of Salvianolic acid B - borneol combination were still unknown. Read More

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https://www.liebertpub.com/doi/10.1089/rej.2018.2099
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http://dx.doi.org/10.1089/rej.2018.2099DOI Listing
December 2018
30 Reads
3.311 Impact Factor

Walnut (Juglans regia L.) kernel extracts protects against isoproterenol-induced myocardial infarction in rats.

Rejuvenation Res 2018 Nov 6. Epub 2018 Nov 6.

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, zhengzhou, China ;

Walnuts kernels (Juglans regia L.) have rich antioxidants content and have been used in both cosmetic and pharmaceutical industry. The current study dealt with the protective role of walnut kernels extracts (WK) on isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Read More

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https://www.liebertpub.com/doi/10.1089/rej.2018.2140
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http://dx.doi.org/10.1089/rej.2018.2140DOI Listing
November 2018
14 Reads

Development and Validation of a Self-Administered Multidimensional Prognostic Index to Predict Negative Health Outcomes in Community-Dwelling Persons.

Rejuvenation Res 2018 Dec 28. Epub 2018 Dec 28.

6 SESPA, Health Service of the Principality of Asturias , Oviedo, Spain .

The multidimensional prognostic index (MPI) is a comprehensive geriatric assessment (CGA)-based tool that accurately predicts negative health outcomes in older subjects with different diseases and settings. To calculate the MPI several validated tools are assessed by health care professionals according to the CGA, whereas self-reported information by the patients is not available, but it could be of importance for the early identification of frailty. We aimed to develop and validate a self-administered MPI (SELFY-MPI) in community-dwelling subjects. Read More

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http://dx.doi.org/10.1089/rej.2018.2103DOI Listing
December 2018
1 Read

Rosmarinic Acid Ameliorates HO-Induced Oxidative Stress in L02 Cells Through MAPK and Nrf2 Pathways.

Rejuvenation Res 2018 Dec 26. Epub 2018 Dec 26.

1 School of Biosciences & Biopharmaceutics and Center for Bioresources & Drug Discovery, Guangdong Pharmaceutical University, Guangzhou, China.

Liver cells are easily damaged by oxidative stress during progression both in liver development and throughout adult life, resulting in tissue pathology that ranges from simple hepatitis to nonalcoholic fatty liver disease. In this study, we determined the attenuation of oxidative stress in liver cells with pretreatment of rosmarinic acid (RA), which is an antioxidant agent from Rosmarinus officinalis. The human liver cell line L02 was damaged by hydrogen peroxide (HO). Read More

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http://dx.doi.org/10.1089/rej.2018.2107DOI Listing
December 2018
15 Reads
3.311 Impact Factor

Recent Updates on the Phytochemistry and Pharmacological Properties of Phlomis viscosa Poiret.

Rejuvenation Res 2019 Jan 8. Epub 2019 Jan 8.

4 Arnie Miller Laboratories, Beer-Sheva, Israel.

Crude ethanolic extracts from Phlomis viscosa Poiret leaves from the Judea region (Israel) are renowned for their remarkable geroprotective properties: anti-inflammatory, anti-diabetic, and anti-cancer. A phytochemical investigation carried out in this study revealed that the tested plant might belong to a particular distinct chemotype because its phytochemicals are different from compounds that were mentioned in the literature. Among the compounds identified by us was diosmin, the synthetic derivatives of which were further obtained and investigated. Read More

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https://www.liebertpub.com/doi/10.1089/rej.2018.2093
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January 2019
35 Reads

A Clinical Trial using Methylation Age to Evaluate Current Anti-Aging Practices.

Authors:
Josh Mitteldorf

Rejuvenation Res 2018 Oct 21. Epub 2018 Oct 21.

Washington University (St Louis), Biology , 654 Carpenter Ln , Philadelphia , Philadelphi, Pennsylvania, United States , 19119.

Recent advances in technology of "aging clocks" based on DNA methylation suggest that it may be possible to measure changes in the rate of human aging over periods as short as a year or two. To the extent that methylation is a valid surrogate for biological age, testing of anti-aging interventions has become radically cheaper and faster. Together with colleagues at UCLA and UCSD, I have initiated a clinical trial to evaluate some of the most popular anti-aging strategies currently deployed by "early adopters" in the lay community of personal health activists. Read More

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https://www.liebertpub.com/doi/10.1089/rej.2018.2083
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http://dx.doi.org/10.1089/rej.2018.2083DOI Listing
October 2018
6 Reads

The results of a cross-over placebo-controlled study of the effect of lavender oil on behavioral and psychological symptoms of dementia.

Rejuvenation Res 2018 Oct 17. Epub 2018 Oct 17.

Ben-Gurion University of the Negev, 26732, Family Medicine and Siaal Research Center for Family Practice and Primary Care, Beer-Sheva, Israel.

Aim: Studies of the effect of aromatherapy on patients with behavioral and psychological symptoms of dementia (BPSD) have yielded contradictory results. One possible explanation for this lack of consistent results is the site of application of the oil. The aim of the study was to evaluate the effect of lavender oil on the rate of BPSD when applied close to and away from the olfactory system. Read More

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https://www.liebertpub.com/doi/10.1089/rej.2018.2123
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October 2018
11 Reads

Anti-Aging Passion and Pragmatism: Effective Bedfellows at Last.

Rejuvenation Res 2018 10;21(5):387-388

SENS Research Foundation , Mountain View, California.

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https://www.liebertpub.com/doi/10.1089/rej.2018.2139
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http://dx.doi.org/10.1089/rej.2018.2139DOI Listing
October 2018
9 Reads

Prevention of Senescence in Vasculature Through Quiescence.

Rejuvenation Res 2018 Oct;21(5):477-481

1 Panorama Research Institute , Sunnyvale, California.

Prevention of cell senescence is a potential means to extend healthspan and perhaps lifespan. Agents that increase NAD+ levels, which are diminished with age, may be senopreventive through restoration of SIRT1 and normal mitochondrial activity. The ketone body [Formula: see text]-hydroxybutyrate ([Formula: see text]-HB) prevents senescence by inducing quiescence in endothelial cells. Read More

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https://www.liebertpub.com/doi/10.1089/rej.2018.2138
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http://dx.doi.org/10.1089/rej.2018.2138DOI Listing
October 2018
17 Reads

Commentary on Some Recent Theses Relevant to Combating Aging: October 2018.

Rejuvenation Res 2018 Oct 9;21(5):482-487. Epub 2018 Oct 9.

Theses reviewed in this issue include "Computational Pathology for Quantifying Spatial Heterogeneity in Digital Images of Tissue Sections from Solid Tumors," "Molecular Analysis of Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Brain Tissue Identifies Disease Mechanisms Associated with Repetitive DNA Elements," "Neuroprotective Potential of the N-Terminal Beta Amyloid Peptide Fragment in the Neurodegeneration, Synaptic Dysfunction and Memory Deficits in Models of Alzheimer's Disease," "pH-triggered Self-Assembly of a PEGylated Peptide Amphiphilic Contrast Agent," "Quantitative Approaches for Profiling the T Cell Receptor Repertoire in Human Tissues," and "Regulation and Repair of Neural Stem Cells and the Neurogenic Niche." Read More

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http://dx.doi.org/10.1089/rej.2018.2136DOI Listing
October 2018
3 Reads

Aloe-Emodin Ameliorates Renal Fibrosis Via Inhibiting PI3K/Akt/mTOR Signaling Pathway In Vivo and In Vitro.

Rejuvenation Res 2018 Oct 24. Epub 2018 Oct 24.

1 Department of Pharmacy, Xijing Hospital, The Fourth Military Medical University , Xian, China .

Fibrosis is the major pathological feature of chronic kidney disease (CKD). Aloe-emodin (AE), one of the main active compounds in Rhubarb, is widely used for renal protection. However, mechanisms implied in the modulation of kidney fibrosis after AE treatment for CKD remain elusive. Read More

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http://dx.doi.org/10.1089/rej.2018.2104DOI Listing
October 2018
5 Reads

Pleiotropic Effects of French Maritime Pine Bark Extract to Promote Healthy Aging.

Authors:
Peter Rohdewald

Rejuvenation Res 2018 Nov 7. Epub 2018 Nov 7.

Institute of Pharmaceutical Chemistry, University of Münster , Münster, Germany .

Extension of the healthy life span is of primary importance for the aging society. Among exercise, healthy nutrition, and mental training, food supplements are widely used as preventive measures to postpone the diverse symptoms of aging. The extract from the bark of the French maritime pine, Pycnogenol, rich on flavonoids, has anti-inflammatory and antioxidative property, proven in in vivo studies. Read More

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https://www.liebertpub.com/doi/10.1089/rej.2018.2095
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http://dx.doi.org/10.1089/rej.2018.2095DOI Listing
November 2018
10 Reads

Antiaging Effects of Urolithin A on Replicative Senescent Human Skin Fibroblasts.

Rejuvenation Res 2018 Oct 25. Epub 2018 Oct 25.

1 Technical Center for Animal , Plant and Food Inspection and Quarantine, Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai, China .

Although the health benefits attributed to urolithin A, such as anticancer, anti-inflammatory, and antioxidant effects, are based on numerous, diverse studies carried out in vitro, the biological effects of urolith A are still not entirely understood. In this study, we explored the biological effects of urolithin A using senescent human skin fibroblasts (HSFs) to determine whether urolithin A has any antiaging potential. Our results showed that urolithin A significantly increased type I collagen expression and reduced matrix metalloproteinase 1 (MMP-1) expression. Read More

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http://dx.doi.org/10.1089/rej.2018.2066DOI Listing
October 2018
4 Reads

The Association of Handgrip Strength and Mortality: What Does It Tell Us and What Can We Do With It?

Rejuvenation Res 2018 Oct 18. Epub 2018 Oct 18.

2 Kevser Ermin Applied Physiology Laboratory, Department of Health, Exercise Science, and Recreation Management, The University of Mississippi , University, Mississippi.

The relationship between grip strength and mortality is often used to underscore the importance of resistance exercise in physical activity guidelines. However, grip strength does not appear to appreciably change following traditional resistance training. Thus, grip strength could be considered reflective of strength independent of resistance exercise. Read More

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http://dx.doi.org/10.1089/rej.2018.2111DOI Listing
October 2018
3 Reads

Baclofen-Loaded Poly (d,l-Lactide-Co-Glycolic Acid) Nanoparticles for Neuropathic Pain Management: In Vitro and In Vivo Evaluation.

Rejuvenation Res 2018 Oct 11. Epub 2018 Oct 11.

1 Department of Biotechnology, Jaypee Institute of Information Technology , Noida, India .

In this work, poly (d,l-lactide-co-glycolic acid) (PLGA) nanoparticles of baclofen (Bcf-PLGA-NPs) were developed and optimized using nanoprecipitation method. The average particle size of the Bcf-PLGA-NP was found to be 124.8 nm, polydispersity index of 0. Read More

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http://dx.doi.org/10.1089/rej.2018.2119DOI Listing
October 2018
4 Reads
3.311 Impact Factor

Biotechnology Governance 2.0: A Proposal for Minimum Standards in Biotechnology Corporate Governance.

Rejuvenation Res 2018 Aug 24. Epub 2018 Aug 24.

University of Oxford, Orthopaedics, Rheumatology and Musculoskeletal Sciences , NOC , Oxford, United Kingdom of Great Britain and Northern Ireland , OX4 1ED ;

Based on experience and the existing limited research literature in biotechnology corporate governance, the authors propose potential attributes of minimum corporate governance standards for biotechnology companies, as a basis for further quantitative and qualitative research. The authors assert that the recent proliferation of biotechnology start-up organisations is substantively changing inter- and intra-organizational cultures throughout the healthcare sector via a 'cascade of governance'. Therefore, governance decisions and actions - both positive and negative - that are instituted in start-up biotech companies may set new norms for other start-up biotech companies, the larger (bio)pharmaceutical companies by which they are acquired and the range of healthcare sub-sector actors that interact with biotechnology companies. Read More

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http://dx.doi.org/10.1089/rej.2018.2122DOI Listing
August 2018
1 Read

Diagnostic and Prognostic Relevance of Red Blood Cell Distribution Width for Vascular Aging and Cardiovascular Diseases.

Rejuvenation Res 2019 Apr 13;22(2):146-162. Epub 2018 Oct 13.

9 Department of Pathobiology and Medical and Forensic Biotechnologies, University of Palermo, Palermo, Italy.

Evidence suggests association of red blood cell distribution width (RDW) with cardiovascular diseases (CVDs). On the contrary, we underline that the sole RDW values cannot represent a valid CVD biomarker. High RDW values are expression of biological effects of a lot of both endogenous and exogenous factors (. Read More

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https://www.liebertpub.com/doi/10.1089/rej.2018.2094
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http://dx.doi.org/10.1089/rej.2018.2094DOI Listing
April 2019
3 Reads

"Aging, Geroscience, and Freedom".

Authors:
Colin Farrelly

Rejuvenation Res 2019 Apr 18;22(2):163-170. Epub 2018 Oct 18.

Department of Political Studies, Queen's University, Kingston, Canada.

In this article, I argue that senescence (biological aging) is one of the greatest threats to human freedom in the 21st century. The two most prominent conceptions of freedom are "negative" and "positive" liberty. The negative conception of liberty equates freedom with the whereas the positive conception equates freedom with having the capacity to be . Read More

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https://www.liebertpub.com/doi/10.1089/rej.2018.2106
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http://dx.doi.org/10.1089/rej.2018.2106DOI Listing
April 2019
4 Reads

The Plasma NAD Metabolome Is Dysregulated in "Normal" Aging.

Rejuvenation Res 2019 Apr 23;22(2):121-130. Epub 2018 Oct 23.

2 Centre for Healthy Brain Ageing, University of New South Wales, School of Psychiatry, Sydney, Australia.

Nicotinamide adenine dinucleotide (NAD) is an essential pyridine nucleotide that serves as an electron carrier in cellular metabolism and plays a crucial role in the maintenance of balanced redox homeostasis. Quantification of NAD:NADH and NADP:NADPH ratios are pivotal to a wide variety of cellular processes, including intracellular secondary messenger signaling by CD38 glycohydrolases, DNA repair by poly(adenosine diphosphate ribose) polymerase (PARP), epigenetic regulation of gene expression by NAD-dependent histone deacetylase enzymes known as sirtuins, and regulation of the oxidative pentose phosphate pathway. We quantified changes in the NAD metabolome in plasma samples collected from consenting healthy human subjects across a wide age range (20-87 years) using liquid chromatography coupled to tandem mass spectrometry. Read More

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http://dx.doi.org/10.1089/rej.2018.2077DOI Listing
April 2019
15 Reads

Data and Corporate Governance in Pharma and Digital Health: A Necessary Regulatory Convergence.

Rejuvenation Res 2018 Aug 9. Epub 2018 Aug 9.

University of Oxford, Oxford, United Kingdom of Great Britain and Northern Ireland ;

Data and Corporate Governance in Pharma and Digital Health: A Necessary Regulatory Convergence. Read More

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http://dx.doi.org/10.1089/rej.2018.2117DOI Listing
August 2018
1 Read

Phytohormone Abscisic Acid Protects Human Neuroblastoma SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Neurotoxicity Through Its Antioxidant and Antiapoptotic Properties.

Rejuvenation Res 2019 Apr 6;22(2):99-108. Epub 2018 Oct 6.

2 Laboratory of Molecular Neuroscience, Kerman Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

Parkinson's disease (PD) is a destroying and prevalent neurodegenerative disease that is characterized by a progressive death of midbrain dopaminergic neurons. It is important to understand the possible neuroprotective effects of reagents that rescue the neurons from death and apoptosis. In this study, we investigated the effects of abscisic acid (ABA) on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in human dopaminergic neuroblastoma SH-SY5Y cell line as an model of PD. Read More

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https://www.liebertpub.com/doi/10.1089/rej.2018.2062
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http://dx.doi.org/10.1089/rej.2018.2062DOI Listing
April 2019
3 Reads

Data and Corporate Governance in Pharma and Digital Health: A Necessary Regulatory Convergence.

Rejuvenation Res 2018 08;21(4):291-293

1 Department of Paediatrics, Healthcare Translation Research Group, University of Oxford , Oxford, United Kingdom .

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http://dx.doi.org/10.1089/rej.2018.2116DOI Listing
August 2018
1 Read