4,452 results match your criteria Regulatory Peptides[Journal]


The merger of Regulatory Peptides and Peptides.

Regul Pept 2014 Nov;194-195:1-2

Institute of Biomedicine and Biocenter of Oulu, Medical Center Oulu, Oulu, Finland.

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http://dx.doi.org/10.1016/j.regpep.2014.11.007DOI Listing
November 2014
5 Reads

WITHDRAWN: Effects of centrally-injected glucagon-like peptide-2 on gastric mucosal blood flow in rats; possible mechanisms.

Regul Pept 2014 Dec 6. Epub 2014 Dec 6.

Uludağ University School of Medicine Department of Physiology, Bursa, Turkey.

This article has been withdrawn at the request of the Publisher. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.12.001DOI Listing
December 2014
6 Reads

Hypothalamic-pituitary thyroid axis alterations in female mice with deletion of the neuromedin B receptor gene.

Regul Pept 2014 Nov 24;194-195:30-5. Epub 2014 Oct 24.

Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, 24210-130, Brazil. Electronic address:

Neuromedin B, a peptide highly expressed at the pituitary, has been shown to act as autocrine/paracrine inhibitor of thyrotropin (TSH) release. Here we studied the thyroid axis of adult female mice lacking neuromedin B receptor (NBR-KO), compared to wild type (WT) littermates. They exhibited slight increase in serum TSH (18%), with normal pituitary expression of mRNA coding for α-glycoprotein subunit (Cga), but reduced TSH β-subunit mRNA (Tshb, 41%), lower intra-pituitary TSH content (24%) and increased thyroid hormone transporter MCT-8 (Slc16a2, 44%) and thyroid hormone receptor β mRNA expression (Thrb, 39%). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01670115140008
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http://dx.doi.org/10.1016/j.regpep.2014.10.002DOI Listing
November 2014
9 Reads

Resistin induces lipolysis and suppresses adiponectin secretion in cultured human visceral adipose tissue.

Regul Pept 2014 Nov 16;194-195:49-54. Epub 2014 Oct 16.

Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, PR China. Electronic address:

Resistin is an adipokine secreted from adipose tissue, which is likely involved in the development of obesity and insulin resistance via its interaction with other organs, as well as affecting adipose tissue function. The impact of resistin treatment on lipolysis and adiponectin secretion in human visceral adipose tissue is currently unknown. Mesenteric adipose tissue samples were obtained from 14 male subjects [age 54±6 yr, body mass index (BMI) 23. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.10.001DOI Listing
November 2014
7 Reads

Insulin-like growth factor-1 inhibits colonic smooth muscle cell apoptosis in diabetic rats with colonic dysmotility.

Regul Pept 2014 Nov 20;194-195:41-8. Epub 2014 Nov 20.

Department of Metabolic Diseases, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address:

Cellular apoptosis and colonic dysmotility are involved in diabetes mellitus (DM) complications. Insulin-like growth factor-1 (IGF-1) is known to affect apoptosis and proliferation. Here, we demonstrated that the treatment of 1500 ng/kg IGF-1 partly recovers the decrease of the muscle thickness, body weight and gastrointestinal transit rate in DM rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01670115140008
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http://dx.doi.org/10.1016/j.regpep.2014.11.005DOI Listing
November 2014
7 Reads

Prior regular exercise reverses the decreased effects of sleep deprivation on brain-derived neurotrophic factor levels in the hippocampus of ovariectomized female rats.

Regul Pept 2014 Nov 20;194-195:11-5. Epub 2014 Nov 20.

Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Electronic address:

Previous studies indicated that brain-derived neurotrophic factor (BDNF) is the main candidate to mediate the beneficial effects of exercise on cognitive function in sleep deprived male rats. In addition, our previous findings demonstrate that female rats are more vulnerable to the deleterious effects of sleep deprivation on cognitive performance and synaptic plasticity. Therefore, the current study was designed to investigate the effects of treadmill exercise and/or sleep deprivation (SD) on the levels of BDNF mRNA and protein in the hippocampus of female rats. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.11.004DOI Listing
November 2014
4 Reads

Orexin administration to mice that underwent chronic stress produces bimodal effects on emotion-related behaviors.

Regul Pept 2014 Nov 20;194-195:16-22. Epub 2014 Nov 20.

Division of Life Sciences, College of Life Sciences and Biotechnology, Korea University, Anam-Dong, Seoul 136-701, Korea. Electronic address:

Orexin plays diverse roles in regulating behaviors, such as sleep and wake, reward processing, arousal, and stress and anxiety. The orexin system may accomplish these multiple tasks through its complex innervations throughout the brain. The emerging evidence indicates a role of orexin in emotional behaviors; however, most of the previous studies have investigated the function of orexin in naïve animals. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.11.003DOI Listing
November 2014
6 Reads

Anti-cancer, immunoregulatory, and antimicrobial activities of the frog skin host-defense peptides pseudhymenochirin-1Pb and pseudhymenochirin-2Pa.

Regul Pept 2014 Nov 13;194-195:69-76. Epub 2014 Nov 13.

Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates; SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK. Electronic address:

Pseudhymenochirin-1Pb (Ps-1Pb) and pseudhymenochirin-2Pa (Ps-2Pa) are host-defense peptides, first isolated from skin secretions of the frog Pseudhymenochirus merlini (Pipidae). Ps-1Pb and Ps-2Pa are highly cytotoxic (LC50<12 μM) against non-small cell lung adenocarcinoma A549 cells, breast adenocarcinoma MDA-MB-231 cells, and colorectal adenocarcinoma HT-29 cells but are also hemolytic against human erythrocytes (LC50=28±2 μM for Ps-1Pb and LC50=6±1 μM for Ps-2Pa). Ps-2Pa shows selective cytotoxicity for tumor cells (LC50 against non-neoplastic human umbilical vein (HUVEC) cells=68±2 μM). Read More

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http://dx.doi.org/10.1016/j.regpep.2014.11.001DOI Listing
November 2014
15 Reads
5 Citations
2.014 Impact Factor

Antimicrobial and immunomodulatory properties of PGLa-AM1, CPF-AM1, and magainin-AM1: potent activity against oral pathogens.

Regul Pept 2014 Nov 13;194-195:63-8. Epub 2014 Nov 13.

Centre for Infection & Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, Northern Ireland, UK. Electronic address:

Cationic amphipathic α-helical peptides are intensively studied classes of host defence peptides (HDPs). Three peptides, peptide glycine-leucine-amide (PGLa-AM1), caerulein-precursor fragment (CPF-AM1) and magainin-AM1, originally isolated from norepinephrine-stimulated skin secretions of the African volcano frog Xenopus amieti (Pipidae), were studied for their antimicrobial and immunomodulatory activities against oral and respiratory pathogens. Minimal effective concentrations (MECs), determined by radial diffusion assay, were generally lower than minimal inhibitory concentrations (MICs) determined by microbroth dilution. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.11.002DOI Listing
November 2014
9 Reads

Carnosine treatment in combination with ACE inhibition in diabetic rats.

Regul Pept 2014 Nov 16;194-195:36-40. Epub 2014 Sep 16.

Vth Department of Medicine, Nephrology, Endocrinology, Diabetology & Rheumatology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

In humans, we reported an association of a certain allele of carnosinase gene with reduced carnosinase activity and absence of nephropathy in diabetic patients. CN1 degrades histidine dipeptides such as carnosine and anserine. Further, we and others showed that treatment with carnosine improves renal function and wound healing in diabetic mice and rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01670115140007
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http://dx.doi.org/10.1016/j.regpep.2014.09.005DOI Listing
November 2014
6 Reads

Expression and release of progalanin in fibroblasts.

Regul Pept 2014 Nov 16;194-195:55-62. Epub 2014 Sep 16.

Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan.

Galanin is a neuropeptide expressed in the central and peripheral nervous systems. Galanin is known to be biosynthesized in neural and endocrine cells, but little evidence exists for its synthesis in other cells. In this study, we explored galanin-releasing nonneural cells using radioimmunoassay, finding that some fibroblasts produced and released the galanin-like immunoreactive component (galanin-LI). Read More

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http://dx.doi.org/10.1016/j.regpep.2014.09.004DOI Listing
November 2014
10 Reads

Analgesic and anti-inflammatory effectiveness of sitagliptin and vildagliptin in mice.

Regul Pept 2014 Nov 16;194-195:23-9. Epub 2014 Sep 16.

Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Nagyerdei krt. 98, 4032 Hungary. Electronic address:

To validate the potential anti-inflammatory and analgesic role of sita- and vildagliptin, five different experimental models were used in mice: i) mustard oil-induced ear edema, ii) neutrophil accumulation, iii) mechanical and iv) thermal touch sensitivity in complete Freund's adjuvant-induced arthritis and v) capsaicin-induced plasma extravasation in the urinary bladder. For the complete examination period in i) the dose of 10mg sitagliptin as well as 1-10mg vildagliptin was found to significantly decrease ear edema as compared to positive control (p<0.05, n=8/group). Read More

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http://dx.doi.org/10.1016/j.regpep.2014.09.006DOI Listing
November 2014
8 Reads

GLP-2: what do we know? What are we going to discover?

Regul Pept 2014 Nov 16;194-195:6-10. Epub 2014 Sep 16.

Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche [STEBICEF], Italy.

Glucagon-like peptide 2 [GLP-2] is a 33-amino acid peptide released from the mucosal enteroendocrine L-cells of the intestine. The actions of GLP-2 are transduced by the GLP-2 receptor [GLP-2R], which is localized in the neurons of the enteric nervous system but not in the intestinal epithelium, indicating an indirect mechanism of action. GLP-2 is well known for its trophic role within the intestine and interest in GLP-2 is now reviving based on the approval of the GLP-2R agonist for treatment of short bowel syndrome [SBS]. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.09.002DOI Listing
November 2014
3 Reads

The neuro-incretin concept.

Authors:
Bo Ahrén

Regul Pept 2014 Nov 16;194-195:3-5. Epub 2014 Sep 16.

Department of Clinical Sciences Lund, Lund University, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.regpep.2014.09.003DOI Listing
November 2014
6 Reads

Dual effects of carnosine on energy metabolism of cultured cortical astrocytes under normal and ischemic conditions.

Regul Pept 2014 Jun-Aug;192-193:45-52. Epub 2014 Sep 3.

Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, College of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address:

Objective: The aim of this study was to investigate the effects of carnosine on the bioenergetic profile of cultured cortical astrocytes under normal and ischemic conditions.

Methods: The Seahorse Bioscience XF96 Extracellular Flux Analyzer was used to measure the oxygen consumption rates (OCRs) and extracellular acidification rates (ECARs) of cultured cortical astrocytes treated with and without carnosine under normal and ischemic conditions.

Results: Under the normal growth condition, the basal OCRs and ECARs of astrocytes were 21. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.08.005DOI Listing
November 2015
131 Reads

Ghrelin and its receptor: the role of the ghrelin signaling system in regulating cardiac function.

Authors:
Takeshi Soeki

Regul Pept 2014 Jun-Aug;192-193:57-8. Epub 2014 Aug 29.

Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 2-50-1 Kuramoto, Tokushima 770-8503, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.regpep.2014.08.004DOI Listing
November 2015
3 Reads

Islet neogenesis-associated protein (INGAP): the role of its endogenous production as a positive modulator of insulin secretion.

Regul Pept 2014 Jun-Aug;192-193:30-4. Epub 2014 Aug 23.

CENEXA, Center of Experimental and Applied Endocrinology, National University of La Plata, La Plata National Research Council, PAHO/WHO Collaborating Center, School of Medical Sciences, 1900 La Plata, Argentina.

Islet neogenesis-associated protein (INGAP) is a peptide found in pancreatic exocrine-, duct- and islet- non-β-cells from normal hamsters. Its increase induced by either its exogenous administration or by the overexpression of its gene enhances β-cell secretory function and increases β-cell mass by a combination of stimulation of cell replication and islet neogenesis and reduction of β-cell apoptosis. We studied the potential modulatory role of endogenous INGAP in insulin secretion using two different experimental approaches. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.08.003DOI Listing
November 2015
6 Reads

Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors.

Regul Pept 2014 Jun-Aug;192-193:35-44. Epub 2014 Aug 23.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, 7006 Trondheim, Norway.

The stomach produces acid, which may play an important role in the regulation of bone homeostasis. The aim of this study was to reveal signaling pathways in the gastric mucosa that involve the acid secretion and possibly the bone metabolism in CCK1 and/or CCK2 receptor knockout (KO) mice. Gastric acid secretion was impaired and the ECL cell signaling pathway was inhibited in CCK2 receptor KO mice but not in CCK1 receptor KO mice. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.08.002DOI Listing
November 2015
10 Reads

Mediators involved in the hyperthermic action of neuromedin U in rats.

Authors:
G Telegdy A Adamik

Regul Pept 2014 Jun-Aug;192-193:24-9. Epub 2014 Aug 7.

Neuroscience Research Group of the Hungarian Academy of Science, Faculty of Medicine, University of Szeged, Szeged, Hungary.

Neuromedin U (NmU), first was isolated from the porcine spinal cord, has subsequently been demonstrated in a number of species, in which it is present in the periphery and also the brain. Two receptors have been identified: NmU1R is mainly present in peripheral tissues, and Nmu2R in the central nervous system. NmU, a potent endogenous anorectic, serves as a catabolic signaling molecule in the brain; it inhibits food uptake, increases locomotion, activates stress mechanism, having cardiovasscular effects and, causes hyperthermia. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.07.004DOI Listing
November 2015
3 Reads

Natriuretic peptides and cerebral hemodynamics.

Regul Pept 2014 Jun-Aug;192-193:15-23. Epub 2014 Aug 6.

Danish Headache Center, Department of Neurology, Glostrup Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2600 Glostrup, Copenhagen, Denmark. Electronic address:

Natriuretic peptides have emerged as important diagnostic and prognostic tools for cardiovascular disease. Plasma measurement of the bioactive peptides as well as precursor-derived fragments is a sensitive tool in assessing heart failure. In heart failure, the peptides are used as treatment in decompensated disease. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.07.003DOI Listing
November 2015
2 Reads

Modulation of proopiomelanocortin gene expression by ethanol in mouse anterior pituitary corticotrope tumor cell AtT20.

Regul Pept 2014 Jun-Aug;192-193:6-14. Epub 2014 Jul 26.

Department of Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA.

In humans, alcoholism is associated with a decrease in basal ACTH and cortisol levels, and blunted pituitary ACTH responses to administered corticotropin-releasing hormone (CRH) during active drinking and after long-term abstinence. Preclinical studies indicate that a persistent decrease in pituitary activation after chronic exposure to ethanol is due to a direct effect of ethanol on the corticotrope of the anterior pituitary. The present studies were undertaken to determine if ethanol has effects on proopiomelanocortin (POMC) gene transcription activity in mouse anterior pituitary corticotrope tumor cell AtT20. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.07.002DOI Listing
November 2015
7 Reads

Expression of ghrelin and its receptor in rats after coronary artery ligation.

Regul Pept 2014 Jun-Aug;192-193:1-5. Epub 2014 Jul 22.

Dept of Cardiology, Wuhan Univ, Renmin Hospital, Wuhan 430060, Hubei Province, PR China. Electronic address:

Ghrelin is a novel growth hormone-releasing peptide, which has been shown to exert beneficial effects on cardiac function and ventricular remodeling. The present study aimed to investigate the expression of ghrelin and the growth hormone (GH) secretagogue receptor 1a (GHSR-1a), and the association with cardiac remodeling in rats with myocardial infarction (MI). Twenty-four hours after ligation of the anterior descending artery (LAD), adult male Sprague-Dawley rats were randomized to 3 d, 7 d and 28 d group. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.07.001DOI Listing
November 2015
68 Reads

The ghrelin-GHSR-1a system in the ocular neuro-humoral regulation. Pearls and controversies.

Regul Pept 2014 Jun-Aug;192-193:53-4. Epub 2014 Jun 13.

Department of Senses Organs, Faculty of Medicine, University of Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.regpep.2014.06.001DOI Listing
November 2015
3 Reads

Peptide drugs that have been developed to treat type 2 diabetes show neuroprotective effects.

Regul Pept 2014 Jun-Aug;192-193:55-6. Epub 2014 Jun 2.

Lancaster University, Division of Biomed Life Sciences, Faculty of Health and Medicine, Furness College, B65, Lancaster LA1 4YQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.regpep.2014.05.002DOI Listing
November 2015
3 Reads

Linagliptin enhances neural stem cell proliferation after stroke in type 2 diabetic mice.

Regul Pept 2014 May 10;190-191:25-31. Epub 2014 May 10.

Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Internal Medicine, Stockholm, Sweden. Electronic address:

Dipeptidyl peptidase 4 (DPP-4) inhibitors are current drugs for the treatment of type 2 diabetes (T2D) based on their main property to enhance endogenous glucagon-like peptide-1 (GLP-1) levels, thus increasing insulin secretion. However, the mechanism of action of DPP-4 inhibition in extra pancreatic tissues has been poorly investigated and it might occur differently from that induced by GLP-1R agonists. Increased adult neurogenesis by GLP-1R agonists has been suggested to play a role in functional recovery in animal models of brain disorders. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.05.001DOI Listing
May 2014
5 Reads

Novel evidence of ghrelin and growth hormone segretagogue receptor expression by human ocular tissues.

Regul Pept 2014 May 6;190-191:18-24. Epub 2014 May 6.

Department of Medicine and Aging Sciences, "G. d'Annunzio" University of Chieti-Pescara, 66013 Chieti, Italy. Electronic address:

Aim Of The Study: The gastrointestinal peptide hormone ghrelin (Ghr) was discovered in 1999 as the endogenous ligand for the growth hormone secretagogue receptor (GHSR-1a). It is a pleiotropic peptide that modulates a wide spectrum of biological activities, such as growth hormone (GH) release, feeding stimulation, adiposity and cardiovascular actions. The presence of Ghr mRNA in the iris and ciliary body (CB) epithelium was recently demonstrated in animal models, where a possible myorelaxing effect on the iris muscles has been suggested. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.04.005DOI Listing
May 2014
6 Reads

Urocortin 2 blocks the suppression of gastric antral contractions induced by lipopolysaccharide in freely moving conscious rats.

Regul Pept 2014 May 2;190-191:12-7. Epub 2014 May 2.

Department of General Medicine, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa 078-8510, Japan. Electronic address:

Lipopolysaccharide (LPS) inhibits gastric antral contractions in conscious rats. Since LPS regulates corticotropin-releasing factor type 2 receptor (CRF2) expression in the rat stomach, and activation of peripheral CRF2 alters gastric motility, we tried to determine the role of peripheral CRF2 in the LPS-induced suppression of gastric antral contractions. Intraluminal gastric pressure waves were measured in freely moving conscious non-fasted rats using the perfused manometric method. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.04.004DOI Listing
May 2014
6 Reads

Exendin-4 promotes the membrane trafficking of the AMPA receptor GluR1 subunit and ADAM10 in the mouse neocortex.

Regul Pept 2014 May 24;190-191:1-11. Epub 2014 Apr 24.

Department of Pharmacology, School of Pharmaceutical Science, Ohu University, 31-1 Misumido, Tomitamachi, Koriyama, Fukushima 963-8611, Japan. Electronic address:

Glucagon-like peptide-1 (GLP-1) is a novel treatment modality for type 2 diabetes mellitus. However, GLP-1 has been suggested as a therapeutic target for Alzheimer's disease (AD). In rodent studies, GLP-1 reduces amyloid beta (Aβ) and facilitates synaptic plasticity. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.04.003DOI Listing
May 2014
6 Reads

Serum adropin levels are decreased in patients with acute myocardial infarction.

Regul Pept 2014 May 13;190-191:46-9. Epub 2014 Apr 13.

Department of Emergency Medicine, Xijing hospital, Fourth Military Medical University, No. 17 Changle West Road, Xi'an 710032, PR China. Electronic address:

Objective: Adropin is a recently identified bioactive protein that is important for energy homeostasis and maintaining insulin sensitivity. We sought to detect serum adropin levels in acute myocardial infarction (AMI) patients.

Methods: We enrolled 138 AMI patients, 114 stable angina pectoris (SAP) patients and 75 controls. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.04.001DOI Listing
May 2014
5 Reads

Adropin: a new regulatory peptide in cardiovascular endocrinology.

Regul Pept 2014 May 12;190-191:41-2. Epub 2014 Apr 12.

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.regpep.2014.04.002DOI Listing
May 2014
3 Reads

Ganglioneuritis is common in rats with enteric neuropathy due to buserelin treatment.

Regul Pept 2014 May 29;190-191:43-5. Epub 2014 Mar 29.

Department of Clinical Sciences, Division of Pathology, Skåne University Hospital Malmö, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1016/j.regpep.2014.03.005DOI Listing
May 2014
4 Reads

Gut hormones--team workers or solo trippers?

Authors:
Jens F Rehfeld

Regul Pept 2014 May 25;190-191:39-40. Epub 2014 Mar 25.

Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.regpep.2014.03.003DOI Listing
May 2014
2 Reads

Molecular characterization and tissue expression of peptide YY in Schizothorax prenanti: effects of periprandial changes and fasting on expression in the hypothalamus.

Regul Pept 2014 May 26;190-191:32-8. Epub 2014 Mar 26.

Department of Aquaculture, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, China. Electronic address:

Peptide YY (PYY) is a potent anorectic neuropeptide implicated in feeding regulation in mammals. However, the involvement of PYY in the feeding behavior of teleosts has not been well understood. In this study, we employed molecular, real-time quantitative PCR and physiological studies to characterize the structure, distribution, and appetite regulatory effects of PYY in Schizothorax prenanti (S. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.03.004DOI Listing
May 2014
56 Reads

Proteinase-activated receptor-1 (PAR1) and PAR2 mediate relaxation of guinea pig internal anal sphincter.

Authors:
Shih-Che Huang

Regul Pept 2014 Feb 11;189:46-50. Epub 2014 Mar 11.

Department of Internal Medicine, E-Da Hospital, Kaohsiung, Taiwan; School of Medicine, I-Shou University, Kaohsiung, Taiwan. Electronic address:

Activation of proteinase-activated receptor-1 (PAR1) and PAR2 stimulates contraction of the rat but relaxation of the guinea pig colon. The aim of the present study was to investigate PAR effects on internal anal sphincter (IAS) motility. We measured relaxation of isolated muscle strips from the guinea pig IAS caused by PAR agonists using isometric transducers. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.03.001DOI Listing
February 2014
9 Reads

Hemodynamic regulator and mitogenic growth factor: re-visiting the age old question with ACE2 and Jak2.

Authors:
Peter P Sayeski

Regul Pept 2014 Feb 11;189:v-vi. Epub 2014 Mar 11.

Department of Physiology and Functional Genomics, University of Florida College of Medicine, 1345 Center Drive, Room M552, PO Box 100274, Gainesville, FL 32610, United States. Electronic address:

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http://dx.doi.org/10.1016/j.regpep.2014.03.002DOI Listing
February 2014
7 Reads

GLP-1 released to the mesenteric lymph duct in mice: effects of glucose and fat.

Regul Pept 2014 Feb 28;189:40-5. Epub 2014 Feb 28.

Department of Clinical Sciences Lund, Lund University, Lund, Sweden. Electronic address:

Using a newly developed in vivo model measuring glucagon-like peptide-1 (GLP-1) in gut lymphatics in mice, we quantified GLP-1 secretion in vivo after glucose versus fat ingestion with and without concomitant DPP-4 inhibition. The mesenteric lymphatic duct was cannulated in anesthetized C57BL6/J mice and lymph was collected in 30 min intervals. Glucose or fat emulsion (Intralipid®) (0. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054822PMC
February 2014
4 Reads

Regulatory Peptides--past, present and future.

Regul Pept 2014 Jan;188:iv

Institute of Biomedicine and Biocenter of Oulu, Medical Center Oulu and Oulu University Hospital, Oulu, Finland. Electronic address:

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http://dx.doi.org/10.1016/S0167-0115(14)00012-3DOI Listing
January 2014
4 Reads

Prolactin is a potential physiological modulator of swine ovarian follicle function.

Regul Pept 2014 Feb 14;189:22-30. Epub 2014 Feb 14.

Dipartimento di Scienze Medico-Veterinarie, Università degli Studi di Parma, Parma, Italy.

Apart from the well established role of prolactin (PRL) in the control of mammary development and lactation, this hormone appears to possess a variety of physiological functions and evidence exists about its expression in many extra-pituitary sites. This experimental work was undertaken to gain knowledge about PRL and its receptor presence in the porcine antral follicle. In particular, we investigated the expression and local production of PRL in follicular fluid, theca and granulosa cells cultured in standard conditions and in hypoxia. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.01.003DOI Listing
February 2014
2 Reads

The effect of ileal interposition surgery on enteroendocrine cell numbers in the UC Davis type 2 diabetes mellitus rat.

Regul Pept 2014 Feb 7;189:31-9. Epub 2014 Feb 7.

Gubra, Hørsholm, Denmark. Electronic address:

Aim: To investigate the short-term effect of ileal interposition (IT) surgery on gut morphology and enteroendocrine cell numbers in the pre-diabetic UC Davis type 2 diabetes mellitus (UCD-T2DM) rat.

Study Design: Two-month old male UCD-T2DM rats underwent either sham (n=5) or IT (n=5) surgery. Intestines were collected 1. Read More

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http://dx.doi.org/10.1016/j.regpep.2014.01.002DOI Listing
February 2014
7 Reads
8 Citations
2.014 Impact Factor

Is association between thyroid hormones and gut peptides, ghrelin and obestatin, able to suggest new regulatory relation between the HPT axis and gut?

Regul Pept 2014 Feb 4;189:17-21. Epub 2014 Feb 4.

Cellular and Molecular Research Center, Obesity Research Center, Research Institute For Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No 24, Parvaneh St, Velenjak, Tehran, Iran. Electronic address:

Background: Ghrelin and obestatin are important appetite- and energy-regulating peptides, secreted by the stomach. These gut peptides and thyroid hormones are involved in metabolism regulation. Although subclinical thyroidism is common, to date, very few studies have been reported about gut hormones in thyroid dysfunction, and their results are controversial. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01670115140000
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http://dx.doi.org/10.1016/j.regpep.2014.01.001DOI Listing
February 2014
10 Reads

Glucose-dependent insulinotropic polypeptide lowers branched chain amino acids in hyperglycemic rats.

Regul Pept 2014 Feb 8;189:11-6. Epub 2014 Jan 8.

Neuroendocrine Cell Biology, Lund University Diabetes Centre, Malmö Sweden.

Hypersecretion of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) has been associated with obesity and glucose intolerance. This condition has been suggested to be linked to GIP resistance. Besides its insulinotropic effect, GIP also directly affects glucose uptake and lipid metabolism. Read More

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http://dx.doi.org/10.1016/j.regpep.2013.12.009DOI Listing
February 2014
3 Reads

Protective effect of short-term treatment with parathyroid hormone 1-34 on oxidative stress is involved in insulin-like growth factor-I and nuclear factor erythroid 2-related factor 2 in rat bone marrow derived mesenchymal stem cells.

Regul Pept 2014 Feb 9;189:1-10. Epub 2014 Jan 9.

Department of Veterinary Physiology, College of Veterinary Medicine/Bio-Safety Research Institute, Chonbuk National University, South Korea. Electronic address:

Bone marrow-derived mesenchymal stem cell (MSC)-mediated regeneration is a promising treatment for degenerative disease and traumatic injuries. MSCs can be isolated from rats using magnetic-activated cell sorting with CD105 antibody. We investigated the relationships between the expression of endogenous insulin-like growth factor-I (IGF-I) and nuclear factor erythroid 2-related factor 2 (Nrf-2) during short-term treatment with parathyroid hormone (PTH) 1-34-induced protective response in MSCs. Read More

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http://dx.doi.org/10.1016/j.regpep.2013.12.008DOI Listing
February 2014
6 Reads

Cardiac C-type natriuretic peptide gene expression and plasma concentrations in neonatal piglets.

Regul Pept 2014 Jan 27;188:66-9. Epub 2013 Dec 27.

Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark. Electronic address:

Background: C-type natriuretic peptide (CNP) is a member of the natriuretic peptide family. Cardiac ANP and BNP expressions are firmly established, whereas CNP expression in the mammalian heart remains controversial. In the present report, we used a porcine model of the neonatal period with high expressions of cardiac ANP and BNP in order to elucidate the cardiac CNP expression profile. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01670115130017
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http://dx.doi.org/10.1016/j.regpep.2013.12.007DOI Listing
January 2014
14 Reads

Effects of chronic glucagon-like peptide-2 therapy during weaning in neonatal pigs.

Regul Pept 2014 Jan 22;188:70-80. Epub 2013 Dec 22.

Panum Institute, University of Copenhagen, Copenhagen, Denmark.

Background: The enteroendocrine hormone glucagon like peptide-2 (GLP-2) and its ligands are under development as therapeutic agents for a variety of intestinal pathologies. A number of these conditions occur in neonates and infants, and thus a detailed understanding of the effects of GLP-2 during the phase of rapid growth during infancy is required to guide the development of therapeutic applications. We studied the effects of GLP-2 in the neonatal pig to determine the potential effects of exogenous administration. Read More

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http://dx.doi.org/10.1016/j.regpep.2013.12.006DOI Listing
January 2014
16 Reads

Unexpected effects of voluntary exercise training on natriuretic peptide and receptor mRNA expression in the ob/ob mouse heart.

Regul Pept 2014 Jan 21;188:52-9. Epub 2013 Dec 21.

Laboratory of Cardiovascular Biochemistry, Centre Hospitalier de L'Université de Montréal-Hôtel-Dieu Research Centre, Montréal, Québec, Canada.

Regular exercise is generally recommended for the treatment of obesity and type 2 diabetes. Exercise reduces body weight, improves glycemic control and cardiovascular (CV) function. This study was designed to determine the impact of voluntary wheel running on the cardiac oxytocin (OT)-natriuretic peptide (NP) system and plasma CV risk factors in the ob/ob mouse, a model of insulin resistance coupled with severe obesity. Read More

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http://dx.doi.org/10.1016/j.regpep.2013.12.005DOI Listing
January 2014
10 Reads

The inhibitory effect of anandamide on oxytocin and vasopressin secretion from neurohypophysis is mediated by nitric oxide.

Regul Pept 2014 Jan 14;188:31-9. Epub 2013 Dec 14.

Centro de Estudios Farmacológicos y Botánicos, CEFYBO-CONICET-UBA, Facultad de Medicina, Paraguay 2155, 1121ABG, Argentina. Electronic address:

The neurohypophyseal hormones oxytocin (OT) and vasopressin (VP) are involved in behavioral, autonomic and neuroendocrine functions. Both peptides are synthesized in magnocellular neurons of paraventricular and supraoptic nuclei at hypothalamic level whose axons terminate in the neurohypophysis (NH), from where OT and VP are released into the systemic circulation. NH contains abundant nitric oxide (NO) synthase suggesting that NO plays a role in the release of these neuropeptides. Read More

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http://dx.doi.org/10.1016/j.regpep.2013.12.004DOI Listing
January 2014
5 Reads

Nesfatin-1 in childhood and adolescent obesity and its association with food intake, body composition and insulin resistance.

Regul Pept 2014 Jan 11;188:21-4. Epub 2013 Dec 11.

Pediatric Department, National Research Centre, Egypt.

Nesfatin-1 is an anorexigenic peptide that controls feeding behavior and glucose homeostasis. However, there is little data that exists regarding nesfatin-1 secretion in obese children and young adolescents. The aim of this study is to investigate serum nesfatin-1 in childhood and adolescent obesity and to study potential correlations with food intake, anthropometric indices, body composition and insulin resistance. Read More

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http://dx.doi.org/10.1016/j.regpep.2013.12.001DOI Listing
January 2014
8 Reads

Des-aspartate-angiotensin I attenuates ICAM-1 formation in hydrogen peroxide-treated L6 skeletal muscle cells and soleus muscle of mice subjected to eccentric exercise.

Regul Pept 2014 Jan 13;188:40-5. Epub 2013 Dec 13.

Agent Diagnostics and Therapeutics Laboratory, Defense & Environmental Research Institute, DSO National Laboratories, 11 Stockpark Road, 117605, Singapore.

L6 skeletal muscle cells overexpressed ICAM-1 when treated with H2O2. Maximum effect was observed at 200 μM H2O2. Des-aspartate-angiotensin I (DAA-I) concentration-dependently attenuated the overexpression. Read More

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http://dx.doi.org/10.1016/j.regpep.2013.12.003DOI Listing
January 2014
4 Reads

Orexin A and B in vitro modify orexins receptors expression and gonadotropins secretion of anterior pituitary cells of proestrous rats.

Regul Pept 2014 Jan 12;188:25-30. Epub 2013 Dec 12.

Instituto de Biología y Medicina Experimental-CONICET, Argentina; Dep Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina. Electronic address:

Aim: Orexin A and orexin B (hypocretins) are neuropeptides synthesized mainly by neurons located in the lateral hypothalamus and projections throughout the brain. They are agonists at both the orexin 1 and orexin 2G protein-coupled receptors. They have been related to arousal, sleep and feeding, autonomic and neuroendocrine functions. Read More

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http://dx.doi.org/10.1016/j.regpep.2013.12.002DOI Listing
January 2014
15 Reads

The actions of neuropeptide SF on the hypothalamic-pituitary-adrenal axis and behavior in rats.

Regul Pept 2014 Jan 5;188:46-51. Epub 2013 Dec 5.

Department of Pathophysiology, University of Szeged, Szeged, Hungary; MTA-SZTE Neuroscience Research Group of the Hungarian Academy of Sciences Szeged, Szeged, Hungary. Electronic address:

Present experiments focused on measuring the effect of neuropeptide SF (NPSF) on the hypothalamus-pituitary-adrenal (HPA) axis and behavior. The peptide was administered in different doses (0.25, 0. Read More

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http://dx.doi.org/10.1016/j.regpep.2013.11.004DOI Listing
January 2014
3 Reads