Am J Physiol Gastrointest Liver Physiol 2021 May 3;320(5):G780-G790. Epub 2021 Mar 3.
Department of Mechanical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois.
In this study, we quantify the work done by the esophagus to open the esophagogastric junction (EGJ) and create a passage for bolus flow into the stomach. Work done on the EGJ was computed using functional lumen imaging probe (FLIP) panometry. Eighty-five individuals underwent FLIP panometry with a 16-cm catheter during sedated endoscopy including asymptomatic controls ( = 14), 45 patients with achalasia ( = 15 each, three subtypes), those with gastroesophageal reflux disease (GERD; = 13), those with eosinophilic esophagitis (EoE; = 8), and those with systemic sclerosis (SSc; = 5). Read More