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Pain Med 2022 Jun;23(Supplement_1):S1-S53

Department of Anesthesiology, Vanderbilt University Medical Centers, Nashville, Tennessee, USA.

There have been some modest recent advancements in the research of Complex Regional Pain Syndrome, yet the amount and quality of the work in this complicated multifactorial disease remains low (with some notable exceptions; e.g., the recent work on the dorsal root ganglion stimulation). Read More

Tech Hand Up Extrem Surg 2022 Jun 10. Epub 2022 Jun 10.

Rubin Institute for Advanced Orthopedics, Hand Surgery, Sinai Hospital.

Various surgical techniques exist to treat de Quervain's stenosing tendovaginitis. Specific surgical techniques for de Quervain's are designed to avoid complications including injury to branches of the superficial branch of the radial nerve, inadequate decompression, reflex sympathetic dystrophy, and palmar subluxation of the released tendons. A simple dorsal incision through the extensor retinaculum is advocated by many as a means to release the compartment while preventing postoperative subluxation. Read More

J ISAKOS 2022 02 4;7(1):27-34. Epub 2021 Oct 4.

Division of Orthopaedic Surgery, McMaster University, 1280 Main Street West, Hamilton, ON, L8N 3Z5, Canada. Electronic address:

Importance: The posterior cruciate ligament (PCL) is involved in almost one-third of all knee injuries. Surgical management of PCL injuries is currently controversial, and no single graft material is determined as superior in primary PCL reconstruction. A growing body of literature has demonstrated the safety and versatility of the quadriceps tendon (QT) autograft in arthroscopic knee ligament reconstruction. Read More

Plast Reconstr Surg 2022 May 10. Epub 2022 May 10.

From private practice.

Background: The clinical features of classic carpal tunnel syndrome are well known. However, some patients who display atypical symptoms and signs of pain and dysesthesias in the hand, worsening of symptoms at night, and above all, inability to make a full fist, respond equally well to carpal tunnel release. This same clinical picture was shared by some patients labeled as having complex regional pain syndrome. Read More

J Vasc Access 2022 Apr 23:11297298221091766. Epub 2022 Apr 23.

Department of Surgery, Sundaram Hospital, Puthur, Trichy, Tamil Nadu, India.

Pain and swelling of a limb following creation of arterio-venous fistula (AVF) are often attributable to vascular disorders like venous hypertension or limb ischaemia. Here we report the case of a 70-years old man who developed pain and swelling of upper limb distal to the AVF during second post-operative week due to a complex regional pain syndrome (CRPS). CRPS is characterized by pain that is disproportionate to the invoking injury, autonomic dysfunction, trophic changes and functional impairment of affected limb. Read More

Zhongguo Zhen Jiu 2022 Apr;42(4):385-9

Affiliated Hospital of Liaoning University of TCM, Shenyang 110032.

Objective: To assess the efficacy on relieving pain and improving the range of motion of shoulder joint in post-stroke shoulder-hand syndrome of phlegm-stasis obstruction in treatment of the combined therapy of eye acupuncture, (Chinese herbal warm dressing technique) and rehabilitation training (eye acupuncture + + rehabilitation) as compared with the combined treatment of and rehabilitation training ( + rehabilitation) and the simple rehabilitation training (rehabilitation).

Methods: A total of 356 patients with post-stroke shoulder-hand syndrome of phlegm-stasis obstruction were randomized into an eye acupuncture + + rehabilitation group (group A, 122 cases, 2 cases dropped off), a + rehabilitation group (group B, 120 cases, 3 cases dropped off) and a rehabilitation group (group C, 114 cases, 1 case dropped off). In the group C, the basic treatment was combined with routine rehabilitation training. Read More

Reg Anesth Pain Med 2022 07 8;47(7):434-436. Epub 2022 Apr 8.

Physical Medicine and Rehabilitation and Anesthesia, McMaster University Michael G DeGroote School of Medicine, Hamilton, Canada.

Background: Recalcitrant complex regional pain syndrome (CRPS) type 1 is a devastating condition.

Case Presentation: We report a case of a patient in their twenties with left hand and forearm CRPS type I, transiently responsive to spinal cord stimulation, thoracic sympathectomy, and multimodal analgesia. The investigators initiated a trial of a single-shot erector spinae plane block at the T2 level, resulting in a clinically significant improvement in pain, function, vasomotor and sudomotor symptoms transiently for a 36-hour interval. Read More

Pain Med 2022 Mar 2. Epub 2022 Mar 2.

Depts. of Anesthesiology & Critical Care Medicine, Neurology, Physical Medicine & Rehabilitation, and Psychiatry & Behavioral Sciences, Johns Hopkins School of Medicine.

Objective: Determine the correlation between post-sympathetic block pain temperature change, and immediate and intermediate-term pain relief.

Design: Retrospective analysis.

Setting: Academic setting. Read More

JBJS Case Connect 2021 08 12;11(3). Epub 2021 Aug 12.

Department of Orthopaedic Surgery, Geisinger Medical Center, Danville, Pennsylvania.

Case: An 11-year-old female patient presented to our clinic with a low-grade lateral ankle sprain that was subsequently treated with a lace-up ankle brace. On the reintroduction of weight bearing, the patient developed recurrent ankle pain and symptoms consistent with complex regional pain syndrome (CRPS) Type 1. On physical examination, the patient was found to have a concurrent chromhidrosis in the injured area, which is a novel presentation of CRPS. Read More

Medicine (Baltimore) 2021 Dec;100(48):e27791

Department of Physical Medicine and Rehabilitation, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.

Rationale: The α-amino-3-hydroxy-5-methy-4-isoxazole propionate (AMPA) receptor plays a critical role in the development and persistence of pain, and AMPA receptor antagonists are considered possible therapeutic targets for controlling pain. This report describes a patient with complex regional pain syndrome (CRPS) type I in the right lower leg and foot who responded well to perampanel, an AMPA receptor antagonist, for managing the chronic pain.

Patient Concern: A 61-year-old woman complained of pain in her right lower leg and foot over a period of 7 year (numeric rating scale: 8) due to CRPS type I. Read More

Zhongguo Zhen Jiu 2022 Jan;42(1):28-32

Department of Rehabilitation, Xuanwu Hospital of Capital Medical University.

Objective: To compare the clinical efficacy differences between - 's meridian diagnosis method combined with Bobath rehabilitation training and Bobath rehabilitation training alone for post-stroke shoulder-hand syndrome (SHS) typeⅠ.

Methods: A total of 106 patients with post-stroke SHS typeⅠwere randomly divided into an observation group (53 cases, 2 cases dropped off ) and a control group (53 cases, 3 cases dropped off ). The patients in the both groups were treated with medications for basic diseases and conventional acupuncture at Waiguan (TE 5), Shousanli (LI 10) and Jianyu (LI 15) on the affected side. Read More

Rheumatol Int 2022 06 8;42(6):937-947. Epub 2022 Jan 8.

Department of Physical Medicine and Rheumatology, Balgrist University Hospital, University of Zürich, 8008, Zürich, Switzerland.

Despite increasing research, the pathophysiology of Complex Regional Pain Syndrome (CRPS) remains poorly understood. Due to its easy accessibility, the skin represents an ideal approach to gain a better understanding of the underlying processes. We conducted a systematic review of original studies investigating potential biomarkers cutaneous biomarkers in CRPS. Read More

BMC Musculoskelet Disord 2022 Jan 5;23(1):34. Epub 2022 Jan 5.

Department of Hand Surgery, Wuxi Ninth People's Hospital, Wuxi, Jiangsu, China.

Background: The aim of this prospective study was to assess the incidence of complex regional pain syndrome type I (CRPS I) in patients with scaphoid waist fracture and to explore associated factors.

Methods: This was a multicenter, prospective observational study. Demographic, imaging indicators and clinical data were collected before the conservative treatment of scaphoid waist fracture patients. Read More

J Clin Orthop Trauma 2022 Jan 29;24:101722. Epub 2021 Nov 29.

Department of Orthopaedics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Pathological conditions with ongoing inflammatory processes result in specific heat signatures at the affected body parts; infrared thermography (IRT) detects these changes and can be utilied in screening such conditions. The modern devices are advanced and their non contact, convenient and precise readings can aid in multiple medical sub fields. Orthopaedics as a broad entity has witnessed utilisation of this technology for different indications and the present scoping review was done to assess these established indications and further scope of its utility. Read More

Cureus 2021 Dec 8;13(12):e20257. Epub 2021 Dec 8.

Oral Medicine and Radiology, Sathyabama Dental College and Hospital, Chennai, IND.

Complex regional pain syndrome (CRPS) is a pathological exaggeration caused by trauma from injections and vaccine administration characterized by severe pain (often burning), hyperesthesia, allodynia, edema, vasomotor changes, decreased range of motion, hyperhidrosis, and trophic changes. It occurs at all ages with female predominance, and the incidence increases until late middle age. Hand and foot involvement is well recognized, and this may spread proximally. Read More

J Pain Res 2021 4;14:3711-3721. Epub 2021 Dec 4.

Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, Shanxi, 030032, People's Republic of China.

Complex regional pain syndrome (CRPS) is a chronic pain disorder characterized by spontaneous or evoked regionally-confined pain which is out of proportion to the initial trauma event. The disease can seriously affect the quality of the patients' life, increase the psychological burden, and cause various degrees of disability. Despite the awareness of CRPS among medical practitioners for over a century, its pathogenesis remains unclear, and the available treatment is still unsatisfactory. Read More

Annu Int Conf IEEE Eng Med Biol Soc 2021 11;2021:2822-2895

Complex Regional Pain Syndrome (CRPS) is a pain disorder that can be triggered by injuries or surgery affecting most often limbs. Its multifaceted pathophysiology makes its diagnosis and treatment a challenging work. To reduce pain, patients diagnosed with CRPS commonly undergo sympathetic blocks which involves the injection of a local anesthetic drug around the nerves. Read More

Pain Pract 2022 03 25;22(3):381-390. Epub 2021 Nov 25.

Department of Rehabilitation Medicine, College of Medicine, Yeungnam University, Daegu, Korea.

Background: Many patients with complex regional pain syndrome (CRPS) experience refractory pain with severe restrictions in the activities of daily living. Oral prednisolone is commonly used to treat these patients.

Purpose: To review previous studies assessing the effects of prednisolone in CRPS patients. Read More

Diagnostics (Basel) 2021 Sep 1;11(9). Epub 2021 Sep 1.

Department of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

Complex regional pain syndrome type I (CRPS I)-or algodystrophy-is a rare disease that usually occurs after a traumatic event. It is characterized by typical clinical findings such as severe and disabling pain disproportionate to the injury, functional limitations, as well as sensory and vasomotor alterations. However, some people do not report any injury associated with algodystrophy onset in personal history. Read More

An Bras Dermatol 2021 Nov-Dec;96(6):721-725. Epub 2021 Sep 14.

Department of Orthopedics and Traumatology, Health Sciences University, Sultan II Abdülhamid Han Training and Research Hospital, Istanbul, Turkey.

Cast immobilization is used in the management of various injuries of joints and/or limbs. A variety of nail disorders have been reported in association with cast immobilization of the forearm and wrist among a limited number of patients so far. The mechanism was not clearly identified in some of these cases. Read More

Pain Pract 2022 02 23;22(2):285-287. Epub 2021 Oct 23.

Anesthesiology Department, KAT General Hospital and Trauma Center, Athens, Greece.

Complex regional pain syndrome type I (CRPS I) is a multifactorial condition that is related to neural damage, and leads to chronic neuropathic pain. Due to its multifactorial nature, there are many methods that have been recruited for its management. Most of them limit the symptoms to some degree, but the most effective of them so far seems to be blockade of the sympathetic innervation of the region. Read More

Mediterr J Rheumatol 2021 Jun 30;32(2):174-175. Epub 2021 Jun 30.

Clinical Immunology and Rheumatology Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Sisli Etfal Hastan Tip Bul 2021 2;55(2):139-145. Epub 2021 Jul 2.

Department of Orthopedics and Traumatology, University of Turin, Turin, Italy.

The aim of this systematic review is to evaluate the efficacy of Vitamin C (VC) in preventing Complex Regional Pain Syndrome type I (CRPS-I) in fractures or surgery of the upper and lower extremities. During December 2020, Scopus and PubMed search was performed to analyze VC supplementation in preventing CRPS-I after trauma and orthopedic care, according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses guideline. Patient, Intervention, Comparison, Outcomes, Study Design model, and a modified version of the Coleman Methodology Score were used to analyze the included studies. Read More

Int Orthop 2021 09 4;45(9):2453-2459. Epub 2021 Aug 4.

Department of Orthopaedics and Traumatology, Centre Hospitalier EpiCURA, Sites Hornu/Baudour, Hainaut, Belgium.

Purpose: Complex regional pain syndrome (CRPS) after foot and ankle surgery has a significant impact on the ability to walk. As the symptomatic treatment of this disaster complication is poor and has low efficacy, a preventive treatment would be beneficial. Vitamin C has been reported to be efficient in preventing CRPS in elective scheduled surgery. Read More

Radiol Case Rep 2021 Sep 3;16(9):2487-2490. Epub 2021 Jul 3.

Faculty of Behavioral, Management and Social Sciences, Department Psychology, Health and Technology, University of Twente, Drienerlolaan 5, 7522NB Enschede, the Netherlands.

Transient osteoporosis of the hip, also termed transient bone marrow edema, is a painful condition often occurring after trivial trauma. It can be diagnosed with MRI in patients whose radiographs are negative or inconclusive. In this case report we describe a 39-year-old female patient with this rare entity, who was successfully treated with oral Alendronate, active vitamin D and calcium supplementation combined with avoiding of weight bearing on the affected hip. Read More

Pain Physician 2021 07;24(4):E393-E406

Wright State University Boonshoft School of Medicine, Fairborn, OH.

Background: Complex regional pain syndrome is a rare, neuropathic disorder that affects fewer than 200,000 individuals in the United States annually. Current treatments often focus on pain management and fall short of relieving symptoms of pain and dystonia in patients.

Objective: The goal of this systematic qualitative review is to evaluate the evidence for the use of low-dose naltrexone in the treatment of chronic pain syndromes. Read More

Korean J Pain 2021 Jul;34(3):250-261

Laboratory of Assesment and Rehabilitation of the Locomotor Apparatus, Department of Health Sciences, Center Araranguá, Federal University of Santa Catarina, Araranguá, Brazil.

Background: Complex regional pain syndrome type I (CRPS-I) consists of disorders caused by spontaneous pain or induced by some stimulus. The objective was to verify the effects of photobiomodulation (PBM) using 830 nm wavelength light at the affected paw and involved spinal cord segments during the warm or acute phase.

Methods: Fifty-six mice were randomized into seven groups. Read More

Pain Ther 2021 Dec 24;10(2):875-892. Epub 2021 Jun 24.

University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA.

Complex regional pain syndrome (CRPS) is a chronic pain condition often involving hyperalgesia and allodynia of the extremities. CRPS is divided into CRPS-I and CRPS-II. Type I occurs when there is no confirmed nerve injury. Read More

Jt Dis Relat Surg 2021 11;32(2):446-453. Epub 2021 Jun 11.

Ağrı Devlet Hastanesi Ortopedi ve Travmatoloji Kliniği, 04200 Ağrı, Türkiye.

Objectives: This study aims to evaluate the clinical and functional results of patients treated with InSafeLOCK® humeral nail and iliac crest autograft for humeral nonunion.

Patients And Methods: A total of 15 patients (11 males, 4 females; mean age: 52.1±15. Read More

J Oncol Pharm Pract 2022 Jan 4;28(1):228-231. Epub 2021 Jun 4.

Oncology Department, Son Llàtzer Hospital, Palma de Mallorca, Spain.

Everolimus is an immunosuppressant agent used in organ transplantation and, more recently, in cancer therapy. It has demonstrated beneficial effects in breast cancer, renal cancer, and neuroendocrine tumours. However, the treatment is not without side effects, some of which are still little known. Read More