2,052 results match your criteria Reflex Epilepsy


Use of a Dynamic Genetic Testing Approach for Childhood-Onset Epilepsy.

JAMA Netw Open 2019 Apr 5;2(4):e192129. Epub 2019 Apr 5.

Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Importance: Although genetic testing is important for bringing precision medicine to children with epilepsy, it is unclear what genetic testing strategy is best in maximizing diagnostic yield.

Objectives: To evaluate the diagnostic yield of an exome-based gene panel for childhood epilepsy and discuss the value of follow-up testing.

Design, Setting, And Participants: A case series study was conducted on data from clinical genetic testing at Children's Hospital of Philadelphia was conducted from September 26, 2016, to January 8, 2018. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.2129DOI Listing
April 2019
2 Reads

Reflex seizure triggering: Learning about seizure producing systems.

Seizure 2019 Mar 28;69:25-30. Epub 2019 Mar 28.

National Institute of Clinical Neurosciences, Budapest, Hungary.

Aim: We aim to study the mechanism of reflex seizure triggering in close link with the system-epilepsy concept.

Method: We use data and theories presented in the literature and scrutinize a few illustrative cases.

Conclusions: The prerequisite of seizure triggering is an epilepsy-prone brain network. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.03.019DOI Listing

Familial adult myoclonic epilepsy: A new expansion repeats disorder.

Seizure 2019 Mar 19;67:73-77. Epub 2019 Mar 19.

Pediatric Neurology and Muscular Diseases Unit, DINOGMI-Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, IRCCS "G. Gaslini" Institute, Genova, Italy. Electronic address:

Familial adult myoclonic epilepsy (FAME), also described with different acronyms (ADCME, BAFME, FEME, FCTE and others), is a high-penetrant autosomal dominant condition featuring cortical hand tremors, myoclonic jerks, and occasional/rare convulsive seizures. Prevalence is unknown since this condition is often under-recognized, but it is estimated to be less than 1/35,000. The disease usually starts in the second decade of life and has been genetically associated with at least 4 different loci (8q24, 2p11. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.03.009DOI Listing
March 2019
1 Read

Sudden Unexpected Death and the Mammalian Dive Response: Catastrophic Failure of a Complex Tightly Coupled System.

Authors:
Frank F Vincenzi

Front Physiol 2019 19;10:97. Epub 2019 Feb 19.

Department of Pharmacology, University of Washington, Seattle, WA, United States.

In tightly coupled complex systems, when two or more factors or events interact in unanticipated ways, catastrophic failures of high-risk technical systems happen rarely, but quickly. Safety features are commonly built into complex systems to avoid disasters but are often part of the problem. The human body may be considered as a complex tightly coupled system at risk of rare catastrophic failure (sudden unexpected death, SUD) when certain factors or events interact. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2019.00097
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http://dx.doi.org/10.3389/fphys.2019.00097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389676PMC
February 2019
3 Reads

Neuro-Behavioral Status and the Hippocampal Expression of Metabolic Associated Genes in Wild-Type Rat Following a Ketogenic Diet.

Front Neurol 2019 5;10:65. Epub 2019 Feb 5.

Division of Brain Science, Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.

While a ketogenic diet (KD) is a well-established therapy for medically intractable epilepsy, clinical evidence of relevant adverse events of a KD has also been reported. We asked whether this kind of diet would have deleterious effects on wild-type brain function by evaluating KD-induced biochemical changes in the hippocampus as well as neurobehavioral changes occurring in wild-type rats. Fifty-four Sprague-Dawley rats were randomly assigned to three groups on postnatal day 28 (P28): wild-type rats fed with a KD qd (daily for 4 weeks, KD) or qod (every other day for 4 weeks, KOD), and wild-type rats fed with standard normal laboratory diet (ND). Read More

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http://dx.doi.org/10.3389/fneur.2019.00065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370680PMC
February 2019
2 Reads

Hippocampus and Insula Are Targets in Epileptic Patients With Glutamic Acid Decarboxylase Antibodies.

Front Neurol 2018 9;9:1143. Epub 2019 Jan 9.

Epilepsy Unit, Department of Neurology, Hospital Clinic i Provincial, Barcelona, Spain.

Antibodies to glutamic acid decarboxylase (GAD ab) have been found in patients with limbic encephalitis (LE) and chronic pharmacoresistant focal epilepsy (FE). The objectives of the study were to: (1) analyze the clinical and neuroimaging course of patients with FE+GAD ab, (2) compare these characteristics with a control group, and (3) describe the most affected cerebral areas with structural and functional imaging. Patients with FE + high titers of GAD ab and a follow-up of at least 5 years were selected. Read More

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http://dx.doi.org/10.3389/fneur.2018.01143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334555PMC
January 2019
8 Reads

Chewing induced reflex seizures ("eating epilepsy") and eye closure sensitivity as a common feature in pediatric patients with SYNGAP1 mutations: Review of literature and report of 8 cases.

Seizure 2019 Feb 22;65:131-137. Epub 2018 Dec 22.

Paracelsus Medical University, Strubergasse 21, 5020 Salzburg, Austria; Hospital for Neuropediatrics and Neurological Rehabilitation, Epilepsy Center for Children and Adolescents, Krankenhausstr. 20, 83569 Vogtareuth, Germany.

Purpose: Heterozygous SYNGAP1 gene mutations have been associated with several forms of idiopathic generalized epilepsy, autism spectrum disorders and delay of psychomotor development. We report eight patients with a SYNGAP1 mutation and chewing/eating induced reflex seizures as new phenotype and compare them to other patients with eating epilepsy and genetic mutations.

Methods: Presentation of clinical and anamnestic features and retrospective analysis of Video-EEG data of a 4 year old index patient with SYNGAP1 mutation and chewing /eating induced seizures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183046
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http://dx.doi.org/10.1016/j.seizure.2018.12.020DOI Listing
February 2019
11 Reads

Wilder Penfield and the vascular hypothesis of focal epilepsy.

Authors:
Richard Leblanc

J Neurosurg 2019 Jan 4:1-7. Epub 2019 Jan 4.

The vascular hypothesis held that posttraumatic epilepsy results from reflex vasoconstriction of cortical arteries around a cerebral scar. Penfield's initial support and eventual refutation of the vascular hypothesis is the subject of this paper, which is based on a review of his clinical charts, operative and electrocorticographic reports, and brain maps held in the Montreal Neurological Institute archives. Penfield and his collaborators discovered that posttraumatic cortical scars are composed of astro-glial fibers, collagen fibrils, and a neo-vascular plexus that anastomoses with the surrounding cortical arteries. Read More

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http://dx.doi.org/10.3171/2018.8.JNS181990DOI Listing
January 2019
1 Read

Epilepsy in children with type 1 diabetes mellitus: Pathophysiological basis and clinical hallmarks.

Eur J Paediatr Neurol 2019 Mar 21;23(2):240-247. Epub 2018 Dec 21.

Pediatric Diabetology Unit, Department of Maternal and Infantile Health, Sapienza University of Rome, Italy.

We provide an overview on the current knowledge about the association between epilepsy and type 1 diabetes mellitus (T1DM). People with T1DM have a 2-6-fold higher risk of epilepsy than the general population. The onset of T1DM anticipates the onset of epilepsy by a mean period between 1,5 and 2,8 years. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.12.006DOI Listing
March 2019
3 Reads

Affect-induced reflex seizures (AIRS): A case series based on a systematic literature review.

Epilepsy Behav 2019 Mar 31;92:18-25. Epub 2018 Dec 31.

Vancouver General Hospital Epilepsy Program, Gordon and Leslie Diamond Health Care Centre, 8257 - 2775 Laurel Street, Vancouver, British Columbia, V5Z 1M9, Canada; University of British Columbia Neuropsychiatry Program, Detwiller Pavilion, UBC Hospital, 2255 Wesbrook Mall, Vancouver, British Columbia, V6T 2A1, Canada. Electronic address:

Seizures are commonly thought to occur in a spontaneous, unpredictable manner. However, it is well-established that a subset of patients with epilepsy can experience reflex seizures that are consistently elicited by a specific stimulus. While various forms of reflex epilepsy have been documented in the literature, acute affective states have not been commonly described as a potential reflex seizure trigger. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.10.036DOI Listing
March 2019
5 Reads

Diving responses elicited by nasopharyngeal irrigation mimic seizure-associated central apneic episodes in a rat model.

Neurobiol Dis 2019 Apr 25;124:408-415. Epub 2018 Dec 25.

Departments of Physiology & Pharmacology, SUNY Downstate Medical Center, Brooklyn, NY, USA; Neurology, SUNY Downstate Medical Center, Brooklyn, NY, USA. Electronic address:

The spread of epileptic seizure activity to brainstem respiratory and autonomic regions can elicit episodes of obstructive apnea and of central apnea with significant oxygen desaturation and bradycardia. Previously, we argued that central apneic events were not consequences of respiratory or autonomic activity failure, but rather an active brainstem behavior equivalent to the diving response resulting from seizure spread. To test the similarities of spontaneous seizure-associated central apneic episodes to evoked diving responses, we used nasopharyngeal irrigation with either cold water or mist for 10 or 60 s to elicit the diving response in urethane-anesthetized animals with or without kainic acid-induced seizure activity. Read More

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http://dx.doi.org/10.1016/j.nbd.2018.12.019DOI Listing
April 2019
1 Read

Seizure-precipitating factors in dogs with idiopathic epilepsy.

J Vet Intern Med 2019 Mar 21;33(2):701-707. Epub 2018 Dec 21.

Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.

Background: Stress, sleep deprivation, and infectious diseases are important seizure-precipitating factors in human epilepsy patients. However, these factors have not been thoroughly studied in epileptic dogs.

Objective: Seizure-precipitating factors are common in dogs with idiopathic epilepsy and the occurrence of these factors associate with the dogs' signalment, personality, and epilepsy-related factors. Read More

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http://doi.wiley.com/10.1111/jvim.15402
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http://dx.doi.org/10.1111/jvim.15402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430923PMC
March 2019
3 Reads

Intravenously Administered Ganaxolone Blocks Diazepam-Resistant Lithium-Pilocarpine-Induced Status Epilepticus in Rats: Comparison with Allopregnanolone.

J Pharmacol Exp Ther 2019 Mar 14;368(3):326-337. Epub 2018 Dec 14.

Marinus Pharmaceuticals, Radnor, Pennsylvania (M.S.S.); Melior Discovery, Exton, Pennsylvania (J.A.G., A.D., R.H.); and Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, Washington (M.B.-H., H.S.W.).

Ganaxolone (GNX) is the 3-methylated synthetic analog of the naturally occurring neurosteroid, allopregnanolone (ALLO). GNX is effective in a broad range of epilepsy and behavioral animal models and is currently in clinical trials designed to assess its anticonvulsant and antidepressant activities. The current studies were designed to broaden the anticonvulsant profile of GNX by evaluating its potential anticonvulsant activities following i. Read More

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http://dx.doi.org/10.1124/jpet.118.252155DOI Listing
March 2019
6 Reads

The electroclinical features of idiopathic generalized epilepsy patients presenting with fixation-off sensitivity.

Epileptic Disord 2018 Dec;20(6):479-489

Epilepsy and Sleep Disorders Unit, Department of Neurology, The Fourth Military Medical University, Xi'an, 710032, China.

To determine the electroclinical features of fixation-off sensitivity (FOS) in patients with idiopathic generalized epilepsy (IGE). We searched the EEG database using the terms "fixation-off sensitivity" and "idiopathic generalized epilepsy" over a four-year period from March 2014 to April 2018 in the Xijing Hospital, Xi'an, China. FOS was evaluated according to the technique proposed by Panayiotopoulos. Read More

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http://dx.doi.org/10.1684/epd.2018.1021DOI Listing
December 2018
4 Reads

Effects of loss of consciousness on maxillofacial fractures in simple falls.

Dent Traumatol 2019 Feb 3;35(1):48-53. Epub 2018 Dec 3.

Department of Oral and Maxillofacial Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.

Background/aims: Loss of consciousness while falling is reported to increase the risk of more severe injury. However, few studies of maxillofacial injuries have been reported. The aim of this study was to investigate the effects of loss of consciousness on maxillofacial fractures in falls on a level surface (simple falls). Read More

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http://doi.wiley.com/10.1111/edt.12452
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http://dx.doi.org/10.1111/edt.12452DOI Listing
February 2019
16 Reads

Hot water epilepsy and SYN1 variants.

Epilepsia 2018 11;59(11):2162-2163

Child Neuropsychiatric Unit, Epilepsy Center, San Paolo Hospital, Department of Health Sciences, University of Milan, Milan, Italy.

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http://dx.doi.org/10.1111/epi.14572DOI Listing
November 2018
4 Reads
4.571 Impact Factor

Case 4: Atypical Cause of Cyanosis While Bathing in an 18-month-old Boy.

Pediatr Rev 2018 Nov;39(11):568-569

Department of Pediatrics at McGovern Medical School, Memorial Hermann Children's Hospital, Houston TX.

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http://dx.doi.org/10.1542/pir.2017-0159DOI Listing
November 2018
3 Reads

Clinical, neuroradiological, and electroencephalographic findings of reflex epilepsies

Turk J Med Sci 2018 Oct 31;48(5):952-955. Epub 2018 Oct 31.

Background/aim: Reflex seizures are defined as epilepsies with seizures induced by a specific afferent stimulus or patient activity alone or in combination with spontaneous seizures, and/or accompanied by photoparoxysmal response on electroencephalogram (EEG). The aim of this study is to review and analyze clinical, neuroradiological, and EEG findings in reflex epilepsies. Materials and methods: The records of 1598 follow-up patients out of 2237 patients who had been examined between July 1995 and August 2017 were analyzed retrospectively. Read More

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http://online.journals.tubitak.gov.tr/openDoiPdf.htm?mKodu=s
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http://dx.doi.org/10.3906/sag-1801-228DOI Listing
October 2018
1 Read

Diaper changing-induced reflex seizures in CDKL5-related epilepsy.

Epileptic Disord 2018 10;20(5):428-433

Child Neuropsychiatry, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona.

Mutations in the CDKL5 (cyclin-dependent kinase-like-5) gene are known to determine early-onset drug resistant epilepsies and severe cognitive impairment with absent language, hand stereotypies, and deceleration of head growth. Reflex seizures are epileptic events triggered by specific stimuli and diaper changing is a very rare triggering event, previously described in individual cases of both focal and unclassified epilepsy, as well as in Dravet syndrome. Our aim was to describe diaper changing-induced reflex seizures as one of the presenting features in a case of CDKL5-related epilepsy, providing video-EEG documentation and focusing discussion on hyperexcitability determined by the disease. Read More

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http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/ep
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http://dx.doi.org/10.1684/epd.2018.0999DOI Listing
October 2018
8 Reads
0.900 Impact Factor

Sleep-related hypermotor epilepsy and peri-ictal hypotension in a patient with syntaxin-1B mutation.

Epileptic Disord 2018 Oct;20(5):413-417

Epilepsy Center, University Hospitals Cleveland Medical Centre, Cleveland, USA, Center for SUDEP Research.

STX1B is a gene that encodes syntaxin-1B. STX1B mutations have recently been implicated in fever-associated epilepsy syndromes. However, these have not previously been reported in sleep-related hypermotor epilepsy. Read More

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http://dx.doi.org/10.1684/epd.2018.0996DOI Listing
October 2018
7 Reads

Genetic (idiopathic) generalized epilepsy with occipital semiology.

Epileptic Disord 2018 10;20(5):434-439

Hospital Ruber Internacional, Madrid.

Idiopathic photosensitive occipital lobe epilepsy (IPOE) is a syndrome that should be suspected in patients with seizures with occipital semiology, photosensitivity, and normal MRI. It should be distinguished from occipital epilepsy of unknown aetiology (cryptogenic) given the differences in management. We reviewed patients with occipital seizures which were investigated in our epilepsy unit during the last three years. Read More

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http://dx.doi.org/10.1684/epd.2018.0994DOI Listing
October 2018

Perineal stimulation triggering seizures in a child with Dravet syndrome.

Seizure 2018 11 9;62:106-107. Epub 2018 Oct 9.

Epilepsy Program, Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, M5G1X8, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183055
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http://dx.doi.org/10.1016/j.seizure.2018.10.001DOI Listing
November 2018
11 Reads

Pathophysiology of corticobasal degeneration: Insights from neurophysiological studies.

J Clin Neurosci 2019 Feb 13;60:17-23. Epub 2018 Oct 13.

Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Centre for Cognitive Neurosciences Salzburg, Salzburg, Austria; University for Medical Informatics and Health Technology, UMIT, Hall in Tirol, Austria.

Background: Several studies have applied electrophysiological techniques to physiologically characterize corticobasal degeneration (CBD).

Methods: We performed a systematic literature search of these studies and reviewed all 25 identified articles.

Results: Conventional electroencephalography (EEG) is usually normal even in the late stages of disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868183082
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http://dx.doi.org/10.1016/j.jocn.2018.10.027DOI Listing
February 2019
15 Reads
1.320 Impact Factor

Prognosis of Juvenile myoclonic epilepsy with eye-closure sensitivity.

Seizure 2018 Nov 17;62:17-25. Epub 2018 Sep 17.

Unidade de Pesquisa e Tratamento das Epilepsias, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil. Electronic address:

Purpose: Eye closure sensitivity (ECS) has been described as a reflex trait in juvenile myoclonic epilepsy (JME). However, there is no consensus regarding its significance on prognosis. The aim of this study is to clarify the long-term impact of ECS documented by a clinical interview and a video-EEG neuropsychological protocol (VNPP) in a series of 133 JME patients. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.09.006DOI Listing
November 2018
11 Reads

Role of mesial temporal lobe structures in sensory processing in humans: a prepulse modulation study in temporal lobe epilepsy.

Exp Brain Res 2018 Dec 22;236(12):3297-3305. Epub 2018 Sep 22.

Department of Neurology, Cerrahpaşa School of Medicine, Istanbul University, Istanbul, Turkey.

Prepulse modulation (PPM) is an electrophysiological method which enables to assess sensory processing in vivo. Reflex responses may be facilitated or inhibited (prepulse inhibition, PPI) after a weak stimulus. Theoretically, in animal studies, the generator of PPI involves pedunculopontine nucleus which is modulated by various structures, including amygdala. Read More

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http://dx.doi.org/10.1007/s00221-018-5380-6DOI Listing
December 2018

POSSIBLE IMPLEMENTATION OF GABAERGIC AND GLUTAMATERGIC SYSTEMS IN REALIZATION OF ANTIEPILEPTIC EFFECTS OF ACOUSTIC RANGE ELECTRO - MAGNETIC FIELDS.

Georgian Med News 2018 Jul-Aug(280-281):112-116

LEPL Beritashvili Center of Experimental Biomedicine, Tbilisi; I. Javakhishvili Tbilisi State University, Tbilisi, Georgia.

Seizure is a clinical manifestation of a hyperexcitable neuronal network, in which, the electrical balance underlying the normal neuronal activity is altered pathologically-excitation (Glutamatergic activity) predominates over inhibition (GABAergic activity). Arresting of seizure activity is carried out by restoration of neurotransmitter balance. This process has a direct relation with ion channel permeability in cell and ion transmembrane movement. Read More

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December 2018
12 Reads

Defective cortex glia plasma membrane structure underlies light-induced epilepsy in mutants.

Proc Natl Acad Sci U S A 2018 09 5;115(38):E8919-E8928. Epub 2018 Sep 5.

Cancer and Developmental Biology Laboratory, National Cancer Institute, Frederick, MD 21702;

Seizures induced by visual stimulation (photosensitive epilepsy; PSE) represent a common type of epilepsy in humans, but the molecular mechanisms and genetic drivers underlying PSE remain unknown, and no good genetic animal models have been identified as yet. Here, we show an animal model of PSE, in , owing to defective cortex glia. The cortex glial membranes are severely compromised in ceramide phosphoethanolamine synthase ()-null mutants and fail to encapsulate the neuronal cell bodies in the neuronal cortex. Read More

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http://dx.doi.org/10.1073/pnas.1808463115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156639PMC
September 2018
8 Reads
9.810 Impact Factor

Study of Uridine Effect on the Development of Audiogenic Tonic Seizures in Krushinsky-Molodkina Strain Rats.

Dokl Biol Sci 2018 Jul 31;481(1):125-127. Epub 2018 Aug 31.

Biology Department, Moscow State University, Moscow, 119234, Russia.

The latency of tonic seizure in response to loud sound (in rats of the Krushinsky-Molodkina strain with audiogenic epilepsy) had been slightly (although statistically significantly) longer after chronic uridine injections (100 mg/kg, i.p., three times a day during 9 or 12 days). Read More

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http://dx.doi.org/10.1134/S0012496618040014DOI Listing

Localizing and lateralizing values of postictal behavioral impairments in epileptic rats.

Epilepsy Behav 2018 10 11;87:195-199. Epub 2018 Aug 11.

Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia.

Transient postictal behavioral impairments in patients with epilepsy provide clues to seizure localization, but no attempt has been made previously to study the localization/lateralization value of postseizure motor disturbances in experimental models of epilepsy. The present study investigated relation of postictal motor deficit to seizure localization in the rat model of sound-induced reflex epilepsy. Sound-induced motor seizures started with a focal brainstem seizure (running) and progressed to a secondarily generalized seizure. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.07.016DOI Listing
October 2018
2 Reads

Paroxysmal Movement Disorder and Epilepsy Caused by a De Novo Truncating Mutation in .

J Pediatr Genet 2018 Sep 14;7(3):114-116. Epub 2018 Jun 14.

Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom.

Mutations in encoding a histone acetyltransferase involved in chromatin remodeling and in other genes involved in histone acetylation and/or deacetylation have been implicated in broad phenotypes of congenital and developmental abnormalities. However, limited genotype-phenotype correlations are available for some of the most rare or recently reported genetic disorders related to chromatin dysregulation. We hereby report a de novo truncating mutation in (c. Read More

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http://dx.doi.org/10.1055/s-0038-1651526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087480PMC
September 2018

Sign and magnitude scaling properties of heart rate fluctuations following vagus nerve stimulation in a patient with drug-resistant epilepsy.

Epilepsy Behav Case Rep 2018 19;10:78-81. Epub 2018 Jun 19.

Autonomous University of the State of Mexico (UAEMex), Faculty of Medicine, Toluca 50180, Mexico.

Vagus nerve stimulation (VNS) therapy has been recently incorporated in Latin America as a treatment for drug-resistant epilepsy. In particular, it is known that linear analysis and fractal parameters of heart rate variability (HRV) are able to indirectly measure cardiac autonomic activity. This case report presents a 17-year-old female with drug-resistant epilepsy implanted with a VNS device. Read More

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http://dx.doi.org/10.1016/j.ebcr.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072651PMC
June 2018
2 Reads

Perampanel chronic treatment does not induce tolerance and decreases tolerance to clobazam in genetically epilepsy prone rats.

Epilepsy Res 2018 10 1;146:94-102. Epub 2018 Aug 1.

Department of Science of Health, School of Medicine and Surgery, University "Magna Graecia" of Catanzaro, Italy. Electronic address:

Tolerance to some therapeutic effects of antiepileptic drugs may account for the development of pharmacoresistance in patients with epilepsy. In the present study, following oral acute pretreatment with the new antiepileptic drug perampanel (0.1, 0. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.07.018DOI Listing
October 2018
11 Reads

Leptin-regulated autophagy plays a role in long-term neurobehavioral injury after neonatal seizures and the regulation of zinc/cPLA2 and CaMK II signaling in cerebral cortex.

Epilepsy Res 2018 10 3;146:103-111. Epub 2018 Aug 3.

Neurology Laboratory, Institute of Pediatric Research, Children's Hospital of Soochow University, No. 303, Jingde Road, 215003, Suzhou, PR China. Electronic address:

Metabolic disorders play an important role in the pathogenesis of many neurological diseases. Recent evidence suggests that leptin levels in peripheral blood and brain are lower in patients with epilepsy. Leptin is an energy-regulating hormone that plays a neuroprotective role in neurodegenerative diseases and brain trauma. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.07.023DOI Listing
October 2018
22 Reads

Recognition and nursing management of reflex anoxic seizures in children.

Br J Nurs 2018 Aug;27(15):886-892

Consultant Paediatrician, Torbay Hospital, Torquay.

Reflex anoxic seizures (RAS) present with a transient loss of consciousness and are triggered by an unexpected stimuli. These are paroxysmal, short-lived episodes of pronounced bradycardia or transient asystole; the episodes are self-limiting, lasting between 15 seconds and 1 minute. RAS are an important differential diagnosis of transient loss of consciousness but they are commonly misdiagnosed as epileptic events. Read More

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http://dx.doi.org/10.12968/bjon.2018.27.15.886DOI Listing
August 2018
3 Reads

Clinical advances in photosensitive epilepsy.

Brain Res 2019 Jan 1;1703:18-25. Epub 2018 Aug 1.

Surgical Neurology Branch, National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States. Electronic address:

Photosensitive epilepsy is the most common subset of reflex epilepsy in humans. It is characterized by an abnormal electroencephalogram trait known as photoparoxysmal response (PPR) corresponding to ictal symptomology in response to intermittent photic stimulation. Increased exposure to photic stimulation through technological and societal advance has had a significant impact on the incidence and interest in photosensitive epilepsy. Read More

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http://dx.doi.org/10.1016/j.brainres.2018.07.025DOI Listing
January 2019
3 Reads

Impaired Sensorimotor Integration in Restless Legs Syndrome.

Front Neurol 2018 11;9:568. Epub 2018 Jul 11.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Restless legs syndrome (RLS) is a complicated sensorimotor syndrome that may be linked to changes in sensorimotor integration. The mechanism of such changes is unclear. The aim of this study was to investigate sensorimotor integration in patients with RLS through transcranial magnetic stimulation-motor evoked potentials (TMS-MEPs) preceded by peripheral electric stimulation. Read More

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http://dx.doi.org/10.3389/fneur.2018.00568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050383PMC
July 2018
2 Reads

A rare self-induced reflex epilepsy: sunflower syndrome.

Acta Neurol Belg 2018 Jul 25. Epub 2018 Jul 25.

Department of Pediatric Neurology, Gazi University School of Medicine, Ankara, Turkey.

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http://dx.doi.org/10.1007/s13760-018-0970-4DOI Listing
July 2018
1 Read

Successful treatment of reflex epilepsy with praxis induction by stimulus avoidance only.

Epilepsy Behav 2018 09 20;86:163-165. Epub 2018 Jul 20.

Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, China. Electronic address:

Purpose: Reflex epilepsy is a type of epilepsy with seizures that are consistently triggered by a specific stimulus. Zipai is a Chinese ancient card game which has been popular in Southern China for hundreds of years. We sought to report and characterize clinical features of patients with reflex epilepsy evoked by playing Zipai. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.04.030DOI Listing
September 2018
11 Reads

Praxis-induced myoclonia: From the neurophysiologist to the patient perspective.

Seizure 2018 Aug 30;60:184-189. Epub 2018 Jun 30.

Unidade de Pesquisa e Tratamento das Epilepsias (UNIPETE), Universidade Federal de São Paulo (UNIFESP/EPM), São Paulo, SP, Brazil. Electronic address:

Purpose: To characterize semiology and EEG features of praxis-induced (PI) myoclonia and to describe the subjective perception of juvenile myoclonic epilepsy (JME) patients with this reflex trait.

Methods: Patients with JME who presented myoclonia during a Video-EEG Neuropsychological Protocol were selected. We analyzed the semiology of upper limbs myoclonia and the ictal EEG patterns on Video-EEG. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.06.022DOI Listing
August 2018
20 Reads

Genetically Epilepsy-Prone Rats Display Anxiety-Like Behaviors and Neuropsychiatric Comorbidities of Epilepsy.

Front Neurol 2018 27;9:476. Epub 2018 Jun 27.

Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC, United States.

Epilepsy is associated with a variety of neuropsychiatric comorbidities, including both anxiety and depression. Despite high occurrences of depression and anxiety seen in human epilepsy populations, little is known about the etiology of these comorbidities. Experimental models of epilepsy provide a platform to disentangle the contribution of acute seizures, genetic predisposition, and underlying circuit pathologies to anxious and depressive phenotypes. Read More

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http://dx.doi.org/10.3389/fneur.2018.00476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030811PMC
June 2018
9 Reads

The Development and Validation of Clinical Exome-Based Panels Using ExomeSlicer: Considerations and Proof of Concept Using an Epilepsy Panel.

J Mol Diagn 2018 Sep 22;20(5):643-652. Epub 2018 Jun 22.

Division of Genomic Diagnostics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; Genetics Department, Al Jalila Children's Specialty Hospital, Dubai, United Arab Emirates. Electronic address:

Exome-based panels are becoming the preferred diagnostic strategy in clinical laboratories. This approach enables dynamic gene content update and, if needed, cost-effective reflex to whole-exome sequencing. Currently, no guidelines or appropriate resources are available to support the clinical implementation of exome-based panels. Read More

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http://dx.doi.org/10.1016/j.jmoldx.2018.05.003DOI Listing
September 2018
1 Citation
4.851 Impact Factor

Maternal reproductive performance and fetal development of the Wistar Audiogenic Rat (WAR) strain.

Syst Biol Reprod Med 2019 Feb 21;65(1):87-94. Epub 2018 Jun 21.

a Department of Gynecology and Obstetrics , Ribeirão Preto School of Medicine, University of São Paulo , Ribeirão Preto, São Paulo , Brazil.

Wistar Audiogenic Rat (WAR) strain is an animal model for epilepsy studies, the chronic multifactorial disease that affects millions of people worldwide. The animals of this strain are genetically predisposed to sound-induced seizures, called audiogenic seizures, and have been used for many years in studies to understand the mechanisms involved in the epilepsies and their neuropsychiatric comorbidities, as well as the screening of potential anti-convulsant agents. Nevertheless, little is known about the reproductive characteristics of these animals. Read More

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http://dx.doi.org/10.1080/19396368.2018.1483443DOI Listing
February 2019
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[Tips for taking the medical history in patients with syncope].

Authors:
Carsten W Israel

Herzschrittmacherther Elektrophysiol 2018 Jun;29(2):144-154

Klinik für Innere Medizin - Kardiologie, Diabetologie & Nephrologie, Evangelisches Klinikum Bethel, Burgsteig 13, 33617, Bielefeld, Deutschland.

Transient loss of consciousness represents one of the most frequent reasons for patients to present in the emergency room. Already at the very beginning, the diagnostic work-up is faced with fundamental questions: (1) Was it really a loss of consciousness? (2) Which department (neurology, cardiology, or others) should check the patient? (3) Is an in-hospital diagnostic work-up required? These questions can be answered from a meticulous patient history which needs to be adjusted to the individual case but also has to systematically go through a list of questions. Patient history has to clarify whether syncope was present. Read More

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http://dx.doi.org/10.1007/s00399-018-0573-zDOI Listing
June 2018
4 Reads

Reflex anoxic seizures (RAS) in an adult patient: a separate entity from epilepsy.

BMJ Case Rep 2018 May 8;2018. Epub 2018 May 8.

Department of Internal Medicine, Allegiance Health, Jackson, Michigan, USA.

Reflex anoxic seizures (RAS) are essential in the differential diagnosis of non-epileptic paroxysmal seizures. They are precipitated by vagally mediated brief cardiac asystole, which in turn leads to transient cerebral ischaemia. RAS are usually seen in infants and preschool children, but in this case happened in a middle-aged man. Read More

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http://dx.doi.org/10.1136/bcr-2017-222389DOI Listing
May 2018
6 Reads

Tap seizures in infancy: A critical review.

Seizure 2018 Jul 23;59:11-15. Epub 2018 Apr 23.

Child Neuropsychiatric Unit, Neuroscience Department, University of Parma, Parma, Italy.

Tap seizure is a type of reflex myoclonic epilepsy in which seizures are evoked mainly by unexpected tactile stimuli and which is classified among the electroclinical syndromes of infancy. This condition, whose onset is in the first two years of life, is characterized by excellent prognosis and is extremely rare. We reviewed all published articles and case reports on Reflex Myoclonic Epilepsies focusing on touch-induced seizures in order to clarify clinical and electroencephalographic findings. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.04.013DOI Listing
July 2018
6 Reads

Emotional stimuli-provoked seizures potentially misdiagnosed as psychogenic non-epileptic attacks: A case of temporal lobe epilepsy with amygdala enlargement.

Epilepsy Behav Case Rep 2018 27;9:37-41. Epub 2017 Apr 27.

Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

The association between emotional stimuli and temporal lobe epilepsy (TLE) is largely unknown. Here, we report the case of a depressed, 50-year-old female complaining of episodes of a "spaced out" experience precipitated by emotional stimuli. Psychogenic non-epileptic attacks were suspected. Read More

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http://dx.doi.org/10.1016/j.ebcr.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913040PMC
April 2017
5 Reads

Electroclinical characteristics and syndromic associations of "eye-condition" related visual sensitive epilepsies-A cross-sectional study.

Seizure 2018 May 30;58:62-71. Epub 2018 Mar 30.

R Madhavan Nayar Centre for Comprehensive Epilepsy Care, Dept of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.

Purpose: The systematic study of visual phenomena such as eye closure (ECLS), eye-closed/fixation-off sensitivity (FOS) [terminology proposed as eye-condition sensitive (ECS) epilepsy] distinct from photosensitivity is rarely explored in literature.

Methods: Clinical, electroencephalographic (EEG) and imaging records of patients attending an epilepsy clinic were screened. Inclusion criterion was demonstrable electrographic visual sensitivitiy in the form of ECS parameters with/without photosensitivity. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.03.027DOI Listing
May 2018
3 Reads

Consensus Paper: Neurophysiological Assessments of Ataxias in Daily Practice.

Cerebellum 2018 Oct;17(5):628-653

Department of Neurology, Essen University Hospital, University of Duisburg-Essen, Essen, Germany.

The purpose of this consensus paper is to review electrophysiological abnormalities and to provide a guideline of neurophysiological assessments in cerebellar ataxias. All authors agree that standard electrophysiological methods should be systematically applied in all cases of ataxia to reveal accompanying peripheral neuropathy, the involvement of the dorsal columns, pyramidal tracts and the brainstem. Electroencephalography should also be considered, although findings are frequently non-specific. Read More

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http://dx.doi.org/10.1007/s12311-018-0937-2DOI Listing
October 2018
9 Reads

Central Regulation of Micturition and Its Association With Epilepsy.

Int Neurourol J 2018 Mar 28;22(1):2-8. Epub 2018 Mar 28.

Department of Pharmacology, The Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Micturition is a complex process involving the bladder, spinal cord, and the brain. Highly sophisticated central neural program controls bladder function by utilizing multiple brain regions, including pons and suprapontine structures. Periaqueductal grey, insula, anterior cingulate cortex, and medial prefrontal cortex are components of suprapontine micturition centers. Read More

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http://dx.doi.org/10.5213/inj.1836040.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885137PMC
March 2018
3 Reads

Weird Laughing in Hyperekplexia: A new phenotype associated with a novel mutation in the GLRA1 gene?

Seizure 2018 May 20;58:6-8. Epub 2018 Mar 20.

Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, 450052, People's Republic of China.

Hyperekplexia (HPX) or startle disease is a rare hereditary neurological disorder characterized by generalized stiffness, excessive startle reflex to unexpected stimuli and a short period of generalized stiffness following the startle response, and can be complicated by umbilical or inguinal hernia, developmental delay and apnea spell. HPX is caused mainly by mutations in the GLRA1 gene, and has a good response to clonazepam. In this short communication we describe an 11-year-old girl with excessive startle reflex, weird laughing and developmental delay since early infancy. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.03.017DOI Listing
May 2018
2 Reads