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Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):315-322. Epub 2018 Dec 12.

Canine leishmaniasis is an emerging infection with increasing importance because the main vector also exists in Germany and autochthonous infections have been described. In this article we present the latest information available regarding therapy and prevention of this disease. Allopurinol-resistant strains were isolated from dogs which experienced recurrent disease while being treated with allopurinol, highlighting the need for alternative treatment options. Read More

Endocr Rev 2018 Dec 12. Epub 2018 Dec 12.

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA.

Pancreatic islet transplantation has become an established approach to β-cell replacement therapy for the treatment of insulin deficient diabetes. Recent progress in techniques for islet isolation, islet culture, and peri-transplant management of the islet transplant recipient have resulted in substantial improvements in metabolic and safety outcomes for patients. For patients requiring total or sub-total pancreatectomy for benign disease of the pancreas, isolation of islets from the diseased pancreas with intrahepatic transplantation of autologous islets can prevent or ameliorate post-surgical diabetes, and for patients previously experiencing painful recurrent acute or chronic pancreatitis, quality-of-life is substantially improved. Read More

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Clinical Pharmacology & Digestive Pathophysiology Unit, Department of Clinical & Experimental Medicine, University of Parma, Parma, Italy.

Vomiting is not only unpleasant for both children and families, but can lead to frequent hospital admission. The persistent vomiting hampers oral intake and increases the risk of dehydration so the proper use of antiemetic drugs can be useful. The pharmacological treatment of vomiting in children remains a challenge for the pediatrician because several antiemetics are prescribed as "off-label", outside their authorized drug label. Read More

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Center for Pancreatic Diseases.

Introduction: Acute pancreatitis (AP) is understudied in the pediatric population despite increasing incidence. Although many cases are mild and resolve with supportive care, severe acute pancreatitis (SAP) can be associated with significant morbidity and mortality. There is a lack of pediatric-specific predictive tools to help stratify risk of SAP in children. Read More

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Section of Pediatric Gastroenterology and Nutrition, Texas Children's Hospital, Baylor College of Medicine, Children's Nutrition and Research Center, Houston, TX.

Fecal microbiota transplantation (FMT) is becoming part of the treatment algorithms against recurrent Clostridium difficile infection (rCDI) both in adult and pediatric gastroenterology practice. With our increasing recognition of the critical role the microbiome plays in human health and disease, FMT is also being considered as a potential therapy for other disorders, including inflammatory bowel disease (Crohn disease, ulcerative colitis), graft versus host disease, neuropsychiatric diseases, and metabolic syndrome. Controlled trials with FMT for rCDI have not been performed in children, and numerous clinical and regulatory considerations have to be considered when using this untraditional therapy. Read More

JBJS Case Connect 2018 Dec 12. Epub 2018 Dec 12.

Department of Orthopaedic Surgery, Showa University Hospital, Tokyo, Japan.

Case: A 49-year-old man presented with apprehension of a repeat dislocation after a left shoulder dislocation, which was accompanied by pain and restricted active range of motion of the shoulder. We performed an arthroscopic Bankart repair as well as an arthroscopic superior capsular reconstruction (ASCR) with fascia lata for the irreparable massive rotator cuff tear. Two years postoperatively, there was no shoulder pain or repeat dislocation; the range of motion had improved. Read More

Clin Nucl Med 2019 Jan;44(1):40-41

Peritoneal carcinomatosis in prostate cancer is extremely rare and has been described in only few cases with high PSA level, androgen deprivation, or in symptomatic patients. To date, 2 cases of Ga-PSMA PET positive peritoneal metastases have been reported. We report a case of urachus metastases showed on Ga-PSMA PET/CT performed for biochemical recurrence with a very low PSA level at 0. Read More

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Department of Dermatology, University Hospital Leipzig (UKL), Germany.

Rev Paul Pediatr 2018 Oct-Dec;36(4):445-450

Universidade Federal de São Paulo, São Paulo, SP, Brasil.

Objective: To assess the prevalence and severity of wheezing in the first year of life of infants, using the standardized protocol of the Estudio Internacional de Sibilancias en Lactantes- phase 3, and compare the values obtained with those found in phase 1, conducted at the same center.

Methods: Between 2009 and 2010, parents and guardians of infants answered the written questionnaire of the Estudio Internacional de Sibilancias en Lactantes - phase 3, and its results were compared to those of phase 1, performed between 2005 and 2006. We divided the infants into wheezing and non-wheezing. Read More

Braz Oral Res 2018 Dec 6;32:e123. Epub 2018 Dec 6.

Hospital General de México "Eduardo Liceaga", Department of Pathology, México City, México.

This study aims to evaluate the clinicopathological features, TNM status, AJCC staging and behavior of squamous cell carcinoma of the tongue (SCCT) in patients older than 45 years. The files of the Department of Pathology of the Hospital General de México were reviewed and all cases of SCCT in patients older than 45 years were selected. Clinicopathological features, treatment, follow-up, microscopic diagnosis, and IJCC and TNM staging were retrieved. Read More

Arq Bras Cir Dig 2018 Dec 6;31(4):e1404. Epub 2018 Dec 6.

Suzhou Affiliated Hospital of Nanjing University of Chinese Medicine, Colorectal Surgery, Su zhou, Jiang su, China.

Background: It is important but difficult to treat complex fistula-in-ano due to the high recurrent rate and following incontinence. Ligation of the intersphincteric fistula tract (LIFT), a novel surgical procedure with the advantage of avoiding anal incontinence, has a variable success rate of 57-94.4 %. Read More

Chin Med J (Engl) 2018 Dec;131(24):3009-3011

Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Dankook University Hospital, Dankook University College of Medicine, Cheonan 31116, Korea.

J Cancer Res Ther 2018 Dec;14(Supplement):S1230-S1232

Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Hepatocellular carcinoma (HCC) with gastric metastasis is seldom reported. It is extremely easy to misdiagnose for primary gastric cancer with liver metastasis, especially gastric hepatoid adenocarcinoma. Here, we report a case of recurrent HCC with gastric metastasis in a 22-year-old man. Read More

Curr Mol Med 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatric Urology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai. China.

Background: Primary hyperoxaluria type 1 (PH1) is an inherited disease caused by mutations in alanine-glyoxylate aminotransferase (AGXT). It is characterized by abnormal metabolism of glyoxylic acid in liver leading to endogenous oxalate overproduction and deposition of oxalate in multiple organs, mainly the kidney. Patients of PH1 often suffer from recurrent urinary tract stones, and finally renal failure. Read More

Surg Innov 2018 Dec 12:1553350618817646. Epub 2018 Dec 12.

1 Keio University, School of Medicine Tokyo, Japan.

Background: Recurrent laryngeal nerve (RLN) paralysis is mainly associated with esophagectomy, and it may result in not only other morbidities, such as aspiration pneumonia, but also in long-term issues. Therefore, an approach to prevent RLN paralysis is necessary. The present study was designed to determine the technical usability of the new hybrid pencil type energy (NP) device developed by Olympus Corporation (Tokyo, Japan) and compare it with a conventional electrosurgical knife (EK) for resection around the RLN lymph nodes. Read More

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Dermatol Ther (Heidelb) 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Acne vulgaris is the most common dermatological disorder worldwide. It is a multifactorial disease that involves increased sebum production, hyperkeratinization of the pilosebaceous unit, Propionibacterium acnes (Cutibacterium acnes) colonization, and inflammation. The human skin microbiome hosts a wide variety of microorganisms, including bacteria, viruses, and fungi. Read More

Cell Mol Neurobiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Anatomical Pathology, School of Medical Sciences, University of Campinas (UNICAMP), Av. Tessália Vieira de Camargo, 126, Campinas, SP, CEP 13083-887, Brazil.

Epilepsy is a common disease presenting with recurrent seizures. Hippocampal sclerosis (HS) is the commonest histopathological alteration in patients with temporal lobe epilepsy (TLE) undergoing surgery. HS physiopathogenesis is debatable. Read More

J Community Health 2018 Dec 11. Epub 2018 Dec 11.

Asian Liver Center, Department of Surgery, Stanford University School of Medicine, 780 Welch Road, CJ 130, Palo Alto, CA, 94304-5787, USA.

Chronic hepatitis B infection (CHB) is a condition that needs ongoing care such as monitoring for liver enzymes (ALT) and HBV DNA tests in treated and untreated patients, and annual imaging evaluation for liver cancer. Although follow-up care and treatment might seem straight forward, an estimated two-thirds of those who are aware of their infection are not seeing a health care provider, and more than half of those who are eligible for treatment do not receive it. This study aimed to compile and examine studies related to the barriers of disease monitoring, treatment, and liver cancer surveillance for CHB patients in the United States (US). Read More

Arch Orthop Trauma Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.

Introduction: Tenosynovial giant-cell tumor also known as pigmented villonodular synovitis (PVS) is a benign but aggressive synovial proliferative disease most often affecting the knee joint. The mainstay of therapy is surgical resection. Due to a high rate of local recurrence, radiosynoviorthesis (RSO) is used as an adjuvant method in many cases. Read More

World J Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgery, KUMC Thyroid Center, Korea University Hospital, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.

Background: Endoscopic transoral thyroidectomy is a recently introduced technique of remote access thyroidectomy. We previously reported the feasibility of the robotic approach (TORT). Nevertheless, experience to date is limited, with scant data on outcomes in patients with papillary thyroid carcinoma (PTC). Read More

Urologe A 2018 Dec 11. Epub 2018 Dec 11.

Radiologische Klinik, Universitätsklinikum Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Deutschland.

Life-threatening bleeding from portosystemic varices is a feared complication of portal hypertension. Particularly, varices in atypical locations-so-called ectopic varices-pose a challenge for diagnosis and therapy. In the present article, we describe the case of a patient with liver cirrhosis and recurrent bleeding from an ileal conduit resulting from peristomal varicosis. Read More

Endosc Int Open 2018 Dec 10;6(12):E1439-E1444. Epub 2018 Dec 10.

Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, MD.

Acute non-variceal upper gastrointestinal bleeding (UGIB) due to peptic ulcer disease (PUD) remains a common and challenging emergency managed by gastroenterologists. The proper role of endoscopic suturing on the management of PUD-related UGIB is unknown.  This is an international case series of patients who underwent endoscopic suturing for bleeding PUD. Read More

Curr Zool 2018 Dec 27;64(6):755-764. Epub 2018 Jan 27.

Museo Nacional de Ciencias Naturales (MNCN-CSIC), Calle de José Gutiérrez Abascal, 2, Madrid, Spain.

Genetic characterization of species using phylogeographic approaches represents a basic reference to understand their evolutionary history as well as to identify conservation priorities to protect areas of particular interest regarding evolutionary potential. Even in well-studied regions such information is lacking for the majority of species, including many endemic species with reduced distribution ranges. We investigate the phylogeographic pattern of the Iberian frog , an endemic amphibian restricted to Central and North-Western Iberian Peninsula. Read More

Front Neurol 2018 27;9:1003. Epub 2018 Nov 27.

Department of Critical Care Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

No previous study has compared the impact of dipyridamole-based triple antiplatelet therapy on secondary stroke prevention and long-term outcomes to that of dual antiplatelet therapy (DAPT) in patients with acute myocardial infarction (AMI) and previous stroke. This study aimed to evaluate the impact of dipyridamole added to DAPT on stroke prevention and long-term outcomes in patients with cerebral infarction after first AMI. This nationwide, case-control study included 75,789 patients with cerebral infarction after first AMI. Read More

Front Neurol 2018 27;9:967. Epub 2018 Nov 27.

Laboratorio di Ricerche di Citogenetica Medica e Genetica Molecolare, Istituto Auxologico Italiano (IRCCS) Milan, Italy.

Splicing pathogenic variants account for a notable fraction of alterations underlying Cornelia de Lange syndrome but are likely underrepresented, due to overlooking of non-canonical intronic variants by traditional and contemporary sequencing methods. We describe five subjects, belonging to three families, displaying a mild Cornelia de Lange syndrome phenotype who carry the pathogenic variant c.5329-15A>G, affecting the IVS27 branch site, yet reported in a single case. Read More

Onco Targets Ther 2018 21;11:8239-8250. Epub 2018 Nov 21.

Department of Internal Medicine, Division of Gastroenterology and Hepatology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan,

Standard treatment options for patients with advanced gastric cancer (GC) offer limited efficacy and are associated with some toxicity, which necessitates the development of more effective therapies for improving the treatment outcomes for this disease. Immunotherapy involving immune checkpoint inhibitors (ICIs) which inhibit the programmed death 1 (PD-1)/programmed death ligand 1 interaction has emerged as a new treatment option. Nivolumab, a human IgG4 monoclonal antibody inhibitor of PD-1, has demonstrated promising clinical activity and induced durable responses in patients with advanced GC. Read More

Vasc Health Risk Manag 2018 20;14:383-392. Epub 2018 Nov 20.

Department of Cardiology, Papa Giovanni XXIII Hospital, Bergamo, Italy.

Objectives: The aim of the study was to assess all-cause mortality and cardiovascular (CV) events in patients after a period of 12 months of treatment with dual antiplatelet therapy (DAPT) after hospitalization for acute myocardial infarction (AMI) in a real-world setting. Health care costs for the management of patients post-AMI was also assessed.

Methods: A retrospective analysis using data from the administrative databases of six local health units (LHUs) was performed. Read More

Indian J Surg Oncol 2018 Dec 19;9(4):640-643. Epub 2018 May 19.

Department of Surgical Oncology, Vikram Hospital, Bangalore, India.

This is a case report of a 61-year-old male patient, presented with fifth recurrence of retroperitoneal liposarcoma and operated for six times. Literature review on retroperitoneal liposarcoma biology, recurrence pattern, role of surgery in primary tumor, and recurrent tumor, adjuvant therapy, role of multivisceral resection, and palliative surgery. Read More

Indian J Surg Oncol 2018 Dec 4;9(4):452-455. Epub 2018 Sep 4.

3Department of Surgical Oncology, Tata Memorial Center, Mumbai, India.

Close surveillance of colorectal cancer (CRC) patients is helpful as early detection of resectable metastasis has a survival benefit. Ultrasonography (USG) is a frequently used modality to detect liver recurrence, although international guidelines do not include it. To evaluate the potential added role of USG in early detection of CRC recurrence. Read More

Am J Gastroenterol 2018 Dec 11. Epub 2018 Dec 11.

Department of Medical and Surgical Sciences, University of Bologna, Azienda Ospedaliero Universitaria S.Orsola Malpighi, Bologna, Italy.

Objectives: Portal vein thrombosis (PVT) is a frequent complication of cirrhosis. Benefit, safety, and duration of anticoagulant treatment in this setting are controversial issues. The aim of this study was to analyze the course of PVT in a large cohort of cirrhotic patients undergoing or not anticoagulation therapy. Read More

MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA

Otitis media (OM) is often polymicrobial, with nontypeable (NTHI) and (Mcat) frequently cocultured from clinical specimens. Bacterial biofilms in the middle ear contribute to the chronicity and recurrence of OM; therefore, strategies to disrupt biofilms are needed. We have focused our vaccine development efforts on the majority subunit of NTHI type IV pili, PilA. Read More

BMC Emerg Med 2018 Dec 11;18(1):53. Epub 2018 Dec 11.

Northeast Georgia Medical Center Barrow, 316 N Broad St, Winder, GA, 30680, USA.

Background: Factitious disorder causing hypoglycemia is a psychiatric condition in which patients deliberately use blood sugar lowering medications to cause severe symptoms for the purposes of hospitalization or other primary gains.

Case Presentation: We report a case of factitious hypoglycemia in a 19-year-old foster care adolescent female who presented to the Emergency Department with recurrent hypoglycemic episodes, to the degree that the patient required large amounts of dextrose and further management by intensive care unit hospitalization. Further inquiry revealed that the patient intentionally injected herself with large doses of insulin for the purposes of seeking hospital admission. Read More

J Cardiol Cases 2014 Jun 16;9(6):245-246. Epub 2014 Apr 16.

Department of Cardiology, Limassol General Hospital, Limassol, Cyprus.

J Cardiol Cases 2014 Jun 16;9(6):236-238. Epub 2014 Apr 16.

Henry Ford Heart and Vascular Institute, Henry Ford Hospital, Detroit, MI, USA.

We report a case of recurrent ventricular tachycardia from severe aortic stenosis that improved after percutaneous aortic balloon valvuloplasty and transcatheter aortic valve replacement. The electrocardiographic features of the arrhythmia were compatible with ventricular tachycardia originating from the left ventricle. Myocardial ischemia and electrolyte abnormalities were ruled out. Read More

J Cardiol Cases 2014 Mar 28;9(3):109-112. Epub 2013 Dec 28.

The Division of Pacing and Electrophysiology, Rambam Health Care Campus and Bruce Rappaport Faculty of Medicine, Haifa, Israel.

We report a case of a 55-year-old woman with idiopathic ventricular fibrillation (VF) who suffered from recurrent implantable cardioverter-defibrillator shocks triggered by short coupled ventricular premature beat (VPB). This VPB was mapped and ablated from the myocardium of right ventricle close to the lateral tricuspid annulus. < Triggering ventricular premature beat (VPB) in idiopathic ventricular fibrillation was reported to originate from the myocardium of right ventricular outflow tract or from Purkinje system. Read More

J Cardiol Cases 2014 Mar 28;9(3):106-108. Epub 2013 Dec 28.

Department of Cardiology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom.

We describe a case of a 45-year-old man presenting with acute myocardial infarction investigated by computed tomography coronary angiography. Interestingly all three coronary arteries arose from the right coronary cusp. The left anterior descending artery (LAD) subtended an acute angle from the aortic root, associated with significant kinking and stenosis at the ostium, before passing anteriorly, taking a sub-pulmonic course and descending in the anterior interventricular groove. Read More

J Cardiol Cases 2014 Mar 12;9(3):91-93. Epub 2013 Dec 12.

Department of Cardiovascular Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan.

A 79-year-old woman undergoing medical treatment with solifenacin and clenbuterol for urinary incontinence was admitted to our hospital because of recurrent syncope. Her syncope appeared one month after the doses of clenbuterol were increased. Torsade de pointes (TdP) was evident on her Holter electrocardiogram at the time when she developed syncope. Read More

J Cardiol Cases 2014 Feb 13;9(2):75-79. Epub 2013 Dec 13.

Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan.

A 64-year-old woman with recurrent mitral valve stenosis was hospitalized 30 years after open commissurotomy. Severe right cerebral embolism occurred at age 58, with left hemiparesis. She was debilitated with cardiac cachexia. Read More

J Cardiol Cases 2013 Dec 29;8(6):179-182. Epub 2013 Oct 29.

Department of Cardiology, National Hospital Organization, Kure Medical Center Chugoku Cancer Center, 3-1 Aoyama-cho, Kure, Hiroshima 737-0023, Japan.

Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome, typically affecting young, healthy women, particularly during the peripartum period. Oral contraceptive use is also recognized as a risk factor for SCAD. In the present report, we describe a case of a young woman with an anterior wall myocardial infarction caused by SCAD of the left anterior descending artery (LAD). Read More

J Cardiol Cases 2011 Oct 12;4(2):e93-e97. Epub 2011 Aug 12.

Centre for Amyloidosis & Acute Phase Proteins, Division of Medicine, Royal Free Campus, University College London Medical School, London, UK.

Idiopathic recurrent pericarditis (IRP) impairs quality of life. Although its precise etiology is not certain, it is believed to be immunologically mediated. Its optimal treatments are unknown. Read More

J Cardiol Cases 2015 Feb 25;11(2):69-72. Epub 2014 Nov 25.

Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.

A 65-year-old man with a history of hypertension was admitted to our hospital with fainting and syncope. He had experienced recurrent syncope since 20 years of age. On admission, systolic heart murmur was audible at the apex of the heart. Read More

J Cardiol Cases 2014 Dec 26;10(6):216-220. Epub 2014 Sep 26.

The Division of Cardiology, Okinawa Chubu Hospital, Okinawa, Japan.

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a multigenic form of cardiomyopathy characterized by myocardial loss and fibrofatty replacement mainly in the right ventricle. Progressive right ventricular dysfunction, ventricular arrhythmias, and sudden cardiac death are the clinical picture of this disease. Despite its clinical importance as a cause of sudden death, ARVC is likely to be under-recognized. Read More

J Cardiol Cases 2014 Oct 6;10(4):136-139. Epub 2014 Aug 6.

Department of Cardiovascular Medicine, Osaka Graduate School of Medicine, Suita, Japan.

A 60-year-old woman with dilated cardiomyopathy was referred to our hospital due to recurrent syncope. The electrocardiogram recorded by an implantable loop recorder during a syncopal episode revealed an episode of ventricular fibrillation lasting almost 3 min that terminated spontaneously. A detailed analysis of the rhythm strip showed that the chaotic rhythm became an organized ventricular rhythm with a cycle length of 220 ms for the last 14 s before it terminated. Read More

J Cardiol Cases 2014 Oct 7;10(4):132-135. Epub 2014 Aug 7.

Department of Cardiology, Ashikaga Red Cross Hospital, Tochigi, Japan.

We report a 55-year-old female patient with refractory vasospastic angina and bronchial asthma treated successfully with corticosteroids. She was diagnosed with vasospastic angina by coronary angiography and the acetylcholine provocation test. Even after administration of oral vasodilators (benidipine, diltiazem, nicorandil, isosorbide mononitrate) she had recurrent chest pain with ST elevation. Read More

J Cardiol Cases 2013 Apr 17;7(4):e104-e108. Epub 2013 Jan 17.

Division of Cardiology, Department of Internal Medicine, Tungs' Taichung MetroHarbor Hospital, No. 699, Sec. 1, Chungchi Rd., Wuchi, Taichung 43503, Taiwan.

Stress cardiomyopathy (SCM) is a syndrome of transient cardiac abnormalities precipitated by intense emotional or physical stress. Differentiating SCM from acute myocardial infarction is often difficult but vital to avoid subjecting SCM patients to unnecessary reperfusion therapy and invasive coronary angiography. For accurate diagnosis, it is important that physicians be familiar with the current diagnostic criteria, most susceptible populations, and typical triggers for SCM. Read More

J Cardiol Cases 2013 Feb 8;7(2):e48-e50. Epub 2012 Dec 8.

Department of Second Section of Cardiology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5 Fuxing Street, Guishan Township, Taoyuan County 33305, Taiwan.

Loss of voice due to vocal cord paralysis, as in Ortner syndrome, is secondary to left recurrent laryngeal nerve palsy. Cardiovascular cause should be listed as a differential diagnosis of hoarseness and is incumbent upon the diagnostic physician to be familiar with the condition. A 56-year-old male presented to our emergency department with shortness of breath due to severe mitral regurgitation. Read More

J Cardiol Cases 2012 Dec 19;6(6):e176-e178. Epub 2012 Aug 19.

Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847, Amanuma-cho, Omiya-ku, Saitama 330-8503, Japan.

A 68-year-old man was referred to our hospital for the evaluation and treatment of chest discomfort and syncope. He was diagnosed with variant angina by prolonged ischemic episode with ST-segment elevation in leads II, III, and aV. His symptoms had a seasonal trend and occurred only from April to September. Read More