8,345 results match your criteria Recurrent Early Pregnancy Loss


Next generation sequencing in recurrent pregnancy loss-approaches and outcomes.

Eur J Med Genet 2019 Apr 13. Epub 2019 Apr 13.

Department of Pathology and Laboratory Medicine, University of British Columbia and, Child and Family Research Institute, 950 West 28th, Vancouver BC, Canada. Electronic address:

Next generation sequencing (NGS) has revolutionized the diagnosis of postnatal genetic diseases, but so far has been used less frequently to study reproductive disorders. Here we provide an overview of approaches and outcomes of genome sequencing for identifying causes of recurrent pregnancy loss (RPL). This includes exome sequencing to look for pathogenic sequence changes in the whole exome or in a preselected list of genes considered important for early embryonic development and pregnancy maintenance, as well as low coverage whole genome sequencing useful for identifying cryptic balanced chromosome rearrangements and copy number variants (CNVs) in couples with RPL and miscarriages. Read More

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http://dx.doi.org/10.1016/j.ejmg.2019.04.001DOI Listing
April 2019
1 Read

Comparison of Celiac Disease Markers in Women with Early Recurrent Pregnancy Loss and Normal Controls.

Am J Reprod Immunol 2019 Apr 12:e13127. Epub 2019 Apr 12.

Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine and Fertility Associates of Memphis, 80Humphreys Center #307, Memphis, TN, 38120, USA.

Problem: Celiac disease (CD) is an autoimmune intestinal inflammatory disease triggered by gluten in the diet. Untreated CD has been associated with pregnancy loss and infertility. The purpose of this study was to screen unselected women with recurrent pregnancy loss (RPL) for markers of CD to determine if a correlation exists between RPL and CD serum markers. Read More

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http://dx.doi.org/10.1111/aji.13127DOI Listing
April 2019
3 Reads

Challenges in diagnosing and managing adult patients with Urea Cycle Disorders.

J Inherit Metab Dis 2019 Apr 1. Epub 2019 Apr 1.

National Centre for Inherited Metabolic Diseases, The Mater Misericordiae University Hospital, Dublin 7, Ireland.

Urea cycle disorders (UCD) are a group of rare inherited metabolic conditions of amino acid catabolism caused by an enzyme deficiency within the hepatic ammonia detoxification pathway. The presentation of these disorders ranges from life-threatening intoxication in the neonate to asymptomatic status in adults. Late-onset UCDs can present for the first time in adulthood and may mimic other causes of acute confusion or psychiatric diseases, and are often associated with neurological symptoms. Read More

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http://dx.doi.org/10.1002/jimd.12096DOI Listing
April 2019
3 Reads

The rate of euploid miscarriage is increased in the setting of adenomyosis.

Hum Reprod Open 2018 4;2018(3):hoy011. Epub 2018 Jul 4.

College of Medicine and Public Health, Flinders University, Sturt Road, Bedford Park, South Australia, Australia.

Study Question: Does the rate of miscarriage increase in the setting of adenomyosis independent of other known risk factors for miscarriage such as maternal age, BMI, embryo genetic status?

Summary Answer: Adenomyosis and high BMI both significantly increase miscarriage risk independent of each other, maternal age and embryo health. This study is the first to suggest that ultra-long down regulation GnRH agonist treatment may reduce the rate of early pregnancy loss in adenomyosis patients.

What Is Known Already: The presence of adenomyosis is known to be associated with lower rates of successful implantation and increased risk of early pregnancy loss. Read More

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http://dx.doi.org/10.1093/hropen/hoy011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276689PMC
July 2018
1 Read

Genetic Variants Contributing to Early Recurrent Pregnancy Loss Etiology Identified by Sequencing Approaches.

Reprod Sci 2019 Mar 17:1933719119831769. Epub 2019 Mar 17.

1 Center For Research in Genetics and Genomics (CIGGUR), GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.

Recurrent pregnancy loss (RPL) affects up to 5% of couples. It is believed that genetic factors contribute to the disease's etiology and pathophysiology. Hundreds of genes represent coherent RPL candidates due to mammalian implantation's inherent complexity. Read More

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http://dx.doi.org/10.1177/1933719119831769DOI Listing
March 2019
1 Read

The role of lymphocytes in fetal development and recurrent pregnancy loss.

Ginekol Pol 2019 ;90(2):109-113

Department of Reproductive Health, Centre of Postgraduate Medical Education, Warsaw, Poland.

Fetal survival and development is supported by the maternal immune system. Questions regarding those mechanisms have risen from development of transplantation medicine and observation of graft rejection. Initial theories of anatomic division, fetal immune immaturity and maternal immune system inertia were found incorrect. Read More

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http://dx.doi.org/10.5603/GP.2019.0019DOI Listing
January 2019
1 Read

Recurrent Non-immune Fetal Hydrops Associated With IPEX Syndrome.

Pediatr Dev Pathol 2019 Feb 27:1093526619834809. Epub 2019 Feb 27.

1 Department of Pathology and Laboratory Medicine, NorthShore University HealthSystem, Evanston, Illinois.

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) is a clinical syndrome associated with mutations in FOXP3 and consequent abnormalities of T regulatory cells. Affected males typically die in infancy or early childhood from a variety of autoimmune conditions. Reports of recurrent pregnancy loss of male fetuses in these families have been accompanied by descriptions of nonimmune fetal hydrops, with or without additional fetal anomalies. Read More

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http://dx.doi.org/10.1177/1093526619834809DOI Listing
February 2019
1 Read

Low molecular weight heparin monotherapy for recurrent abortion with antiphospholipid system: A protocol of a systematic review.

Medicine (Baltimore) 2019 Feb;98(8):e14619

Department of Gynecology, First Affiliated Hospital of Jiamusi University, Jiamusi, China.

Background: Previous clinical studies reported low molecular weight heparin (LMWH) monotherpay has been utilized for the treatment of recurrent abortion (RCA) with antiphospholipid system (APS). However, its efficacy is still inconclusive. This systematic review aims to assess its efficacy and safety for patients with RCA and APS. Read More

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http://dx.doi.org/10.1097/MD.0000000000014619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408107PMC
February 2019
2 Reads

Recombinant human granulocyte- colony stimulating factor in women with unexplained recurrent pregnancy losses: a randomized clinical trial.

Hum Reprod 2019 Mar;34(3):424-432

Nora Therapeutics, Inc., 530 Lytton Avenue, 2nd Floor, Palo Alto, CA, USA.

Study Question: Does administration of recombinant human granulocyte colony stimulating factor (rhG-CSF) in the first trimester improve pregnancy outcomes, among women with a history of unexplained recurrent pregnancy loss?

Summary Answer: rhG-CSF administered in the first trimester of pregnancy did not improve outcomes among women with a history of unexplained recurrent pregnancy loss.

What Is Known Already: The only previous randomized controlled study of granulocyte colony stimulating factor in recurrent miscarriage in 68 women with unexplained primary recurrent miscarriage found a statistically significant reduction in miscarriage and improvement in live birth rates. A further four observational studies where G-CSF was used in a recurrent miscarriage population were identified in the literature, two of which confirmed statistically significant increase in clinical pregnancy and live birth rates. Read More

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http://dx.doi.org/10.1093/humrep/dey393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389865PMC
March 2019
2 Reads

Decidual RANKL/RANK interaction promotes the residence and polarization of TGF-β1-producing regulatory γδ T cells.

Cell Death Dis 2019 Feb 8;10(2):113. Epub 2019 Feb 8.

Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, 200011, Shanghai, People's Republic of China.

Abstact: Decidual γδΤ (dγδΤ) cells play an essential role during successful pregnancy; however, the residence and polarization of γδΤ cells in decidua remain unclear. In this study, we observed higher levels of receptor activator for nuclear factor-κ B ligand (RANKL) on decidual stromal cells (DSCs), and its receptor RANK on dγδΤ cells in decidua from normal pregnancy compared with patients with recurrent spontaneous abortion (RSA). RANKL expressed by DSCs can induce the polarization of peripheral blood γδΤ (pγδΤ) and dγδΤ cells to Foxp3 + γδΤ cells, and upregulate the expression of transforming growth factor (TGF)-β1. Read More

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http://dx.doi.org/10.1038/s41419-019-1380-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368618PMC
February 2019
2 Reads

Transabdominal cerclage for cervical insufficiency in twins: series of seven cases and literature review.

J Matern Fetal Neonatal Med 2019 Feb 22:1-5. Epub 2019 Feb 22.

a Obstetrics Department , Cliniques Universitaires Saint Luc , Brussels , Belgium.

Background: The diagnosis of cervical insufficiency is based on the previous history of recurrent second or early third trimester losses. Its incidence among pregnant women is 0.5-1% but can be as high as 75% among women with preterm birth. Read More

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http://dx.doi.org/10.1080/14767058.2019.1579192DOI Listing
February 2019
4 Reads

Risk markers of reproductive loss in women with hyperandrogenism.

Wiad Lek 2018;71(8):1550-1553

Ukrainian Medical Stomatological Academy, Poltava, Ukraine.

Objective: Introduction: The frequency of the pathological course of pregnancy with hyperandrogenism ranges from 21 to 48%. With the predominance of androgens against the background of lowering the normal products of steroidogenesis, a pro-inflammatory immune imbalance is formed, which causes a premature termination of the development of pregnancy. Many studies indicate that hyperandrogenism is a factor in the development of obstetric pathology, including placental dysfunction. Read More

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January 2018
14 Reads

Gene polymorphism associated with endothelial nitric oxide synthase (4VNTR, G894T, C786T) and unexplained recurrent spontaneous abortion risk: A meta-analysis.

Medicine (Baltimore) 2019 Jan;98(4):e14175

Department of First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.

To evaluate the association between endothelial nitric oxide synthase gene polymorphisms (4VNTR A/B, G894T, C786T) and risk of URSA.Related case-control studies were collected by computers. A meta-analysis was conducted using Stata 12. Read More

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http://dx.doi.org/10.1097/MD.0000000000014175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358376PMC
January 2019
16 Reads

Preimplantation genetic diagnosis in early pregnancy loss.

Semin Perinatol 2019 Mar 20;43(2):116-120. Epub 2018 Dec 20.

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Columbia University Medical Center, 5 Columbus Circle, PH New York, NY 10019, USA.

Miscarriage is a frequent outcome seen in obstetrics with 1 in 5 pregnancies ending in an early pregnancy loss. Aneuploidy is the most significant single factor affecting early pregnancy failure and miscarriage. The risk of aneuploidy increases significantly with increasing maternal age. Read More

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http://dx.doi.org/10.1053/j.semperi.2018.12.009DOI Listing
March 2019
8 Reads

Correction: PreImplantation factor (PIF) protects cultured embryos against oxidative stress: relevance for recurrent pregnancy loss (RPL) therapy.

Oncotarget 2018 Dec 18;9(99):37344. Epub 2018 Dec 18.

Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

[This corrects the article DOI: 10.18632/oncotarget.16028. Read More

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http://dx.doi.org/10.18632/oncotarget.26505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324672PMC
December 2018
3 Reads

[Effect of occupational stress on recurrent spontaneous abortion in women of childbearing age].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Nov;36(11):840-843

Institute of Research Center, Gansu Provincial Maternity and Child-care Hospital, Lanzhou 730030, China.

To investigate the influence of occupational stress on recurrent spontaneous abortion (RSA) in women of childbearing age. From January to December, 2017, 75 working women of childbearing age (25-35 years) who were admitted to a provisional hospital in Lanzhou, China and diagnosed with RSA were assigned into patient group. At a 1∶4 ratio, 300 age-matched working women who had normal first pregnancy were randomly selected as controls. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2018.11.011DOI Listing
November 2018
17 Reads

Involvement of ILR4α and TLR4 in miscarriages.

J Reprod Immunol 2019 Feb 8;131:36-43. Epub 2019 Jan 8.

Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.

Background: The purpose of this study was to analyze the involvement of signaling via Interleukin-4-Receptor α (IL4Rα) and Toll like receptor (TLR) 4 at the fetomaternal interface in the process of early pregnancy.

Patients And Methods: Placenta specimens of 46 patients in early pregnancy were analyzed (normal pregnancy (n = 15), spontaneous (n = 15) and habitual abortion (n = 16)). TLR4 and IL4Rα were analyzed by immunohistochemistry, immunofluorescence and real time PCR. Read More

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http://dx.doi.org/10.1016/j.jri.2018.12.001DOI Listing
February 2019
6 Reads
2.815 Impact Factor

Risk factors for miscarriage among women attending an early pregnancy assessment unit (EPAU): a prospective cohort study.

Ir J Med Sci 2019 Jan 3. Epub 2019 Jan 3.

Pregnancy Loss Research Group, Department of Obstetrics and Gynaecology, University College Cork, Cork, Ireland.

Background: Miscarriage is the most common adverse outcome in early pregnancy; however, high proportion of miscarriages are classified as unexplained. In addition, pregnant women attending early pregnancy assessment units might be more vulnerable.

Aims: The purpose of this study was to explore the risk factors that might be associated with miscarriage among women attending an early pregnancy assessment unit (EPAU). Read More

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http://link.springer.com/10.1007/s11845-018-1955-2
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http://dx.doi.org/10.1007/s11845-018-1955-2DOI Listing
January 2019
9 Reads

Trophoblast-derived hyaluronan promotes the regulatory phenotype of decidual macrophages.

Reproduction 2019 02;157(2):189-198

The Affiliated Suzhou Hospital of Nanjing Medical University/Suzhou Municipal Hospital, Suzhou, China.

There is delicate crosstalk between fetus-derived trophoblasts (Tros) and maternal cells during normal pregnancy. Dysfunctions in interaction are highly linked to some pregnancy complications, such as recurrent spontaneous abortion (RSA), pre-eclampsia and fetal growth restriction. Hyaluronan (HA), the most abundant component of extracellular matrix, has been reported to act as both a pro- and an anti-inflammatory molecule. Read More

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https://rep.bioscientifica.com/view/journals/rep/157/2/REP-1
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http://dx.doi.org/10.1530/REP-18-0450DOI Listing
February 2019
15 Reads

The Effect of Low Molecular Weight Heparin in Recurrent Pregnancy Loss: Changes in Radial Uterine Artery Blood Flow and Peripheral Blood NK Cell Fraction.

Egypt J Immunol 2018 Jun;25(2):75-85

Embaba general hospital, Cairo, Egypt.

Immunological alteration has been suggested as a cause of unexplained early recurrent pregnancy loss (RPL). Natural killers (NKs) have been reported to play a role in vascular remodeling of decidual vessels. We aimed to find out if there is a relationship between peripheral blood NKs (pbNKs) and uterine radial artery (uRA) blood flow, and if low molecular weight heparin (LMWH) is effective in improving uRA blood flow in RPL cases and pregnancy outcome. Read More

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June 2018
8 Reads

Genetic Predisposition to Unexplained Recurrent Pregnancy Loss: Killer Cell Immunoglobulin-Like Receptor Gene Polymorphisms as Potential Biomarkers.

Genet Test Mol Biomarkers 2019 Jan 26;23(1):57-65. Epub 2018 Dec 26.

1 Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University , Mersin, Turkey .

Aim: The aim of this study was to investigate the association between killer cell immunoglobulin-like receptor (KIR) gene polymorphisms and unexplained recurrent pregnancy loss (URPL).

Materials And Methods: This study included 70 URPL patients with a history of two or more miscarriages and 70 healthy multiparous women as a control group. KIR genotyping was performed in all subjects for the KIRs 2DL1-4 and 2DS1-5 genes using polymerase chain reaction with sequence-specific primers. Read More

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http://dx.doi.org/10.1089/gtmb.2018.0082DOI Listing
January 2019
4 Reads

[Comparison of the etiological constitution of two and three or more recurrent miscarriage].

Zhonghua Fu Chan Ke Za Zhi 2018 Dec;53(12):855-859

Center for Reproductive Medicine, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

To compare the etiological constitution of recurrent miscarriage (RM) between patients with consecutive two and three or more miscarriages through combining the routine examination results and embryonic karyotype. Patients with a history of two or more consecutive clinical miscarriages (≤12 weeks of gestation) consulting in the RM clinic of the First Affiliated Hospital of Sun Yat-sen University from March 2011 to January 2016 were collected. Six hundred and ninety-six with detailed history recorded, routine clinical examinations of RM and at least once embryonic karyotype were ultimately enrolled in this study. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2018.12.010DOI Listing
December 2018
11 Reads

Efficacy of Antenatal Intravenous Immunoglobulin Treatment in Pregnancies at High Risk due to Alloimmunization to Red Blood Cells.

Transfus Med Hemother 2018 Nov 31;45(6):429-436. Epub 2018 Oct 31.

Department of Gynecology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany.

Background: Alloimmunization to red blood cells (RBCs) may result in fetal anemia prior to 20 weeks gestation. The question as to whether early commencement of antenatal treatment with high-dose intravenous immunoglobulins (IVIG) may prevent or at least delay the development of fetal anemia in the presence of alloantibodies to RBCs is highly relevant.

Patients And Results: Here we describe a patient with high-titer anti-K and two other severely affected pregnant women with a history of recurrent pregnancy loss due to high-titer anti-D or anti-D plus anti-C. Read More

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http://dx.doi.org/10.1159/000490154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288630PMC
November 2018
3 Reads

[Diagnosis and treatment of antiphospholipid antibody-related recurrent spontaneous abortion and analysis of therapeutic drugs and pregnancy outcome in 75 patients with antiphospholipid syndrome].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):956-961

Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing 100191, China.

Recurrent spontaneous abortion is one of the common complications in women of childbearing age during pregnancy. The immune factor accounts for a large proportion of many causes. Antiphospholipid antibody syndrome is the most common type of acquired thrombophilia disease. Read More

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December 2018
2 Reads

Effect of miR-30e regulating NK cell activities on immune tolerance of maternal-fetal interface by targeting PRF1.

Biomed Pharmacother 2019 Jan 13;109:1478-1487. Epub 2018 Nov 13.

Reproductive Medical Center, Renmin Hosptial of Wuhan University, Wuhan 430060, PR China. Electronic address:

Aim: Natural killer (NK) cells, as key regulatory cells, accumulate at the maternal-fetal interface in large numbers. This study explored the effect of miR-30e on regulating the activity and function of peripheral blood NK cells (PB-NK cells) and decidua NK cells (D-NK cells) by targeting PRF1 in immune tolerance of maternal-fetal interface.

Methods: Expressions of miR-30e in PB and decidua tissues from 49 patients with recurrent spontaneous abortion and 52 normal pregnant women were measured using PCR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183317
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http://dx.doi.org/10.1016/j.biopha.2018.09.172DOI Listing
January 2019
15 Reads

Anti-nociceptive and anti-inflammatory potentials of Akebia saponin D.

Eur J Pharmacol 2019 Feb 1;845:85-90. Epub 2018 Dec 1.

Beijing Chao-Yang Hospital Affiliated with Beijing Capital Medical University, Beijing, China. Electronic address:

Akebia saponin D, which is originates from Dipsacus asper Wall, has been used as a tonic, an analgesic and anti-inflammatory agent for the therapy of low back pain, rheumatic arthritis, traumatic hematoma, habitual abortion and bone fractures in traditional Chinese medicine. However, the anti-nociceptive and anti-inflammatory activity and mechanism of Akebia saponin D has been rarely reported. The aim of this study was to investigate the anti-nociceptive and anti-inflammatory activity of Akebia saponin D and to assess its possible mechanism. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00142999183069
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http://dx.doi.org/10.1016/j.ejphar.2018.11.038DOI Listing
February 2019
18 Reads

The role of the PD-1/PD-L1 axis in macrophage differentiation and function during pregnancy.

Hum Reprod 2019 Jan;34(1):25-36

Family Planning Research Institute, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.

Study Question: What is the role of the programmed cell death-1 (PD-1)/PD-1 ligand-1 (PD-L1) axis in macrophage polarization during early pregnancy?

Summary Answer: PD-1 signaling is a major regulator of macrophage differentiation and function, and it is critical for the success of a pregnancy.

What Is Known Already: The predominance of decidual macrophages (DMs) with an M2 phenotype is an important contributor to maternal-fetal tolerance during early pregnancy.

Study Design, Size, Duration: Twenty-four women with recurrent miscarriage (RM) and 70 women undergoing elective termination of an early normal pregnancy (NP) were included. Read More

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http://dx.doi.org/10.1093/humrep/dey347DOI Listing
January 2019
3 Reads

Robot-assisted transabdominal cerclage for the prevention of preterm birth: A multicenter experience.

Eur J Obstet Gynecol Reprod Biol 2019 Jan 12;232:70-74. Epub 2018 Nov 12.

George Washington University, Department of Obstetrics and Gynecology, Division of Minimally Invasive Gynecologic Surgery, Washington, DC, United States. Electronic address:

Objective: High-risk pregnancy stratification and the use of Progesterone and prophylactic cerclage based on prior obstetrical outcomes and cervical length screening have been successful in curbing the impact of preterm birth. However, a large number of women will still suffer from preterm delivery even with optimal management. Experts agree that a transabdominal cerclage is the next best option for women who fail a transvaginal cerclage in a prior pregnancy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03012115183108
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http://dx.doi.org/10.1016/j.ejogrb.2018.11.013DOI Listing
January 2019
21 Reads

Antiphospholipid syndrome in obstetrics.

Authors:
M Kemp W Thomas

Lupus 2018 Oct;27(1_suppl):28-31

2 Department of Haematology, Haemophilia & Thrombophilia Centre, Addenbrooke's Hospital, Cambridge, UK.

Antiphospholipid syndrome (APS) covers a spectrum of clinical manifestations ranging from recurrent pregnancy loss and obstetric complications from placental dysfunction through to thrombotic disease. This article will focus on the common manifestations of the pregnancy-related complications of APS. This includes clinical manifestations, diagnosis and management, as general practitioners will need to be able to recognize the disorder and will also have patients under their care receiving treatment for APS. Read More

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http://dx.doi.org/10.1177/0961203318801664DOI Listing
October 2018
4 Reads

The enhancer RNA lnc-SLC4A1-1 epigenetically regulates unexplained recurrent pregnancy loss (URPL) by activating CXCL8 and NF-kB pathway.

EBioMedicine 2018 Dec 16;38:162-170. Epub 2018 Nov 16.

State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, China. Electronic address:

Background: Enhancer RNAs (eRNAs) are a group of lncRNAs transcribed from enhancers, whose regulatory effects on gene expression are an emerging area of interest. However, the role of eRNAs in regulating trophoblast cells and unexplained recurrent pregnancy loss (URPL) remains elusive.

Methods: We profiled eRNAs in villi from URPL patients and matched controls by RNA-seq. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183050
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http://dx.doi.org/10.1016/j.ebiom.2018.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306333PMC
December 2018
18 Reads

The relationship between sperm DNA fragmentation, free radicals and antioxidant capacity with idiopathic repeated pregnancy loss.

Reprod Biol 2018 Dec 14;18(4):330-335. Epub 2018 Nov 14.

Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, P.O. Box: 16635-148, Tehran, Iran. Electronic address:

More than two consecutive miscarriages in less than 20 weeks of gestation is defined as recurrent spontaneous miscarriage. Various causes such as uterine anatomical anomalies, genetic factors, and infectious and endocrine disorders have been reported for RPL. However, approximately 50% of the causes are unknown, which can be due to male factors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1642431X183015
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http://dx.doi.org/10.1016/j.repbio.2018.11.002DOI Listing
December 2018
20 Reads

Cytogenetic screening in couples with Habitual Abortions.

J Gynecol Obstet Hum Reprod 2019 Mar 6;48(3):155-158. Epub 2018 Nov 6.

Harran University, Faculty of Medicine, Department of Obstetrics and Gynecology, Sanliurfa, Turkey.

Objective: Habitual abortion (HA) is defined at least three consecutive pregnancy losses. One of the etiologic causes is parental chromosomal anomalies. In this study, we aimed to that investigate the effect of parental chromosomal abnormalities on HA. Read More

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http://dx.doi.org/10.1016/j.jogoh.2018.10.021DOI Listing
March 2019
2 Reads

The role of immunotherapy in in vitro fertilization and recurrent pregnancy loss: a systematic review and meta-analysis.

Fertil Steril 2018 11;110(6):1089-1100

Centre for Reproductive and Genetic Health, London, United Kingdom.

Objective: To study the current evidence on the role of immunotherapy in IVF and in the management of recurrent pregnancy loss (RPL).

Design: Systematic review and meta-analysis.

Setting: A literature search was performed using MEDLINE, PUBMED, CINAHL, and EMBASE until May 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00150282183056
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http://dx.doi.org/10.1016/j.fertnstert.2018.07.004DOI Listing
November 2018
20 Reads

The powerful association of angiotensin-converting enzyme insertion/deletion polymorphism and idiopathic recurrent pregnancy loss.

Authors:
Evren Gumus

Ginekol Pol 2018 ;89(10):573-576

Department of Medical Genetics, Faculty of Medicine, University of Harran, 63000 Sanliurfa, Turkey.

Objectives: Idiopathic recurrent pregnancy loss (IRPL) is one of the most troublesome complications of pregnancy. Several researches were also conducted to search the possible association with ACE I/D polymorphism and IRPL. In the light of these reports, this case-control study was investigated to genotypes and alleles of ACE I/D polymorphism in IRPL group and control group. Read More

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https://journals.viamedica.pl/ginekologia_polska/article/vie
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http://dx.doi.org/10.5603/GP.a2018.0098DOI Listing
April 2019
14 Reads

The role of three-dimensional ultrasound in pregnancies submitted to cerclage.

Rev Assoc Med Bras (1992) 2018 Jul;64(7):620-626

Department of Obstetrics and Gynaecology, São Paulo University School of Medicine, São Paulo - SP, Brasil.

Objective: Cervical cerclage is the standard treatment for cervical incompetence (CI); however, there is still a high risk of preterm birth for women who undergo this treatment. The aim of this study was to longitudinally evaluate findings on two-dimensional transvaginal ultrasonography (2DTVUS) and three-dimensional transvaginal ultrasonography (3DTVUS) that could be related to gestational age at birth.

Methods: A total of 68 pregnant women who were treated with cerclage were evaluated by 2DTVUS and 3DTVUS in the second and third trimesters of pregnancy. Read More

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http://dx.doi.org/10.1590/1806-9282.64.07.620DOI Listing
July 2018
2 Reads

[The Analysis of Actual Approaches in Evaluating Efficiency of Medical Care of Female Patients with Habitual Miscarriage].

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2018 Jul;26(4):236-239

The State Budget Institution of Health Care "The M.P. Konchalovsky State Clinical Hospital" of the Moscow Health Care Department, Moscow, 124489, Russia.

The prevalence of habitual miscarriage varies depending on territories of the Russian Federation and other countries. The rate of premature delivery in the Moscow Zelenograd administrative okrug in 2013-2015 in average made up to 4.5%-4. Read More

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http://dx.doi.org/10.32687/0869-866X-2018-26-4-236-239DOI Listing
July 2018
6 Reads

Obstetric antiphospholipid syndrome.

Lupus Sci Med 2018 25;5(1):e000197. Epub 2018 Sep 25.

Unit of Rheumatology, Department of Medicine, Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

The present clinical and laboratory classification criteria for antiphospholipid syndrome (APS) were established in Sydney, Australia, in 2006. In this review, we focus on the obstetric subset of APS (OAPS), defined by persistent positivity for antiphospholipid antibodies together with either early recurrent pregnancy loss, early fetal death, stillbirth or premature birth <34 gestational weeks due to pre-eclampsia, eclampsia and placental insufficiency. It is important to diagnose these cases since most women suffering from OAPS can, when given appropriate treatment, have successful pregnancies. Read More

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http://dx.doi.org/10.1136/lupus-2016-000197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195166PMC
September 2018
26 Reads

Surgical correction of T-shaped uteri in women with reproductive failure: Long term anatomical and reproductive outcomes.

J Gynecol Obstet Hum Reprod 2019 Jan 22;48(1):39-44. Epub 2018 Oct 22.

VKF American Hospital, Women's Health Center Assisted Reproduction Unit, Istanbul, Turkey; VKF Koc University School of Medicine, Department of Obstetrics and Gynecology, Istanbul, Turkey.

Objective: To evaluate the long term anatomical and reproductive outcomes of hysteroscopic treatment for T shaped uterus in patients presenting with reproductive failure.

Methods: This prospective cohort study included 56 patients with a history of long-standing unexplained infertility, recurrent implantation failure (RIF), and/or recurrent pregnancy loss (RPL) who were eligible for metroplasty by office hysteroscopy. Office hysteroscopy under conscious sedation was performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24687847183034
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http://dx.doi.org/10.1016/j.jogoh.2018.10.013DOI Listing
January 2019
12 Reads

Opposing roles of inter-α-trypsin inhibitor heavy chain 4 in recurrent pregnancy loss.

EBioMedicine 2018 Nov 19;37:535-546. Epub 2018 Oct 19.

Department of Biomedical Science, CHA University, CHA General Hospital, Gyeonggi-Do 463-400, Republic of Korea. Electronic address:

Background: The mechanism behind an increased risk of recurrent pregnancy loss (RPL) remains largely unknown. In our previous study, we identified that inter-α-trypsin inhibitor heavy chain 4 (ITI-H4) is highly expressed at a modified molecular weight of 36 kDa in serum derived from RPL patients. Yet, the precise molecular mechanism and pathways by which the short form of ITI-H4 carries out its function remain obscure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183044
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http://dx.doi.org/10.1016/j.ebiom.2018.10.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286651PMC
November 2018
12 Reads

Pancreatic autoimmunity: An unknown etiology on patients with assisted reproductive techniques (ART)-recurrent reproductive failure.

PLoS One 2018 22;13(10):e0203446. Epub 2018 Oct 22.

Department of Immunology and Department of Reproductive Endocrinology and Infertility, Valentian Infertility Institute (IVI), IVI RMA, Madrid, Madrid, Spain.

Pancreatic Autoimmunity is defined as the presence of autoantibodies and more frequent need for insulin treatment. Affected women presenting recurrent implantation failure (RIF) or recurrent miscarriage (RM) are often misdiagnosed. The objective of thestudy was to describe clinical and metabolic profiles suggestive of Pancreatic Autoimmunity and therapeutic strategy in patients with RIF/RM. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203446PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197630PMC
March 2019
12 Reads

CAPS Mutations Are Potentially Associated with Unexplained Recurrent Pregnancy Loss.

Am J Pathol 2019 Jan 17;189(1):124-131. Epub 2018 Oct 17.

Graduate School of Peking Union Medical College, Beijing, China; Center for Genetics, National Research Institute for Family Planning, Beijing, China.

Recurrent pregnancy loss (RPL) is a major concern for women's reproductive health. Several studies have proved that genetics is a major factor leading to unexplained RPL, but the maternal pathogenic genes involved in RPL remain largely unknown. A consanguineous family, including the parents who were cousins and their three daughters who had been diagnosed as having nonsyndromic unexplained RPL, was recruited in this study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029440183038
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http://dx.doi.org/10.1016/j.ajpath.2018.09.010DOI Listing
January 2019
20 Reads

Correlation between CTLA4 genetic polymorphisms, its serum protein level and the susceptibility to recurrent spontaneous abortion: A case-control study.

Medicine (Baltimore) 2018 Oct;97(42):e12754

Department of Obstetrics and Gynecology, First Affiliate Hospital of Jinan University.

Present study was aimed to detect the influence of cytotoxic T-lymphocyte associated protein 4 (CTLA4) gene polymorphisms for the risk of recurrent spontaneous abortion (RSA), as well as the serum level of CTLA4 protein in RSA patients.One hundred thirty-three RSA patients and 146 healthy persons were recruited in this case-control study. PCR-RFLP was used to genotype the CTLA4 gene polymorphisms both in case and control groups. Read More

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http://dx.doi.org/10.1097/MD.0000000000012754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211885PMC
October 2018
24 Reads
5.720 Impact Factor

New insights into the mechanisms underlying recurrent pregnancy loss.

J Obstet Gynaecol Res 2019 Feb 16;45(2):258-265. Epub 2018 Oct 16.

Division of Biomedical Sciences, Clinical Science Research Laboratories, Warwick Medical School, University of Warwick, Coventry, UK.

Recurrent pregnancy loss (RPL), defined as multiple consecutive miscarriages, is a devastating disorder for which there are no good treatment options. Two opposing paradigms have emerged to explain RPL. The prevailing clinical viewpoint is that RPL is caused by a spectrum of subclinical disorders, ranging from thrombophilia to anatomical, endocrine and immunological disorders, that somehow converge on a 'fragile' early pregnancy state, leading to miscarriage. Read More

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http://doi.wiley.com/10.1111/jog.13837
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http://dx.doi.org/10.1111/jog.13837DOI Listing
February 2019
18 Reads

Advances in the management of early pregnancy loss.

Curr Opin Obstet Gynecol 2018 12;30(6):419-424

Division of Family Planning Services & Research, Department of Obstetrics & Gynecology, Stanford University, Stanford, California, USA.

Purpose Of Review: To describe recent advances in management of early pregnancy loss.

Recent Findings: Addition of mifepristone to current protocols for medical management of miscarriage increases effectiveness of a single dose of misoprostol and significantly reduces subsequent aspiration procedures. Women with an incomplete evacuation after medical management may be treated expectantly with similar rates of complete expulsion compared with surgical management at 6 weeks. Read More

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http://Insights.ovid.com/crossref?an=00001703-900000000-9929
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http://dx.doi.org/10.1097/GCO.0000000000000501DOI Listing
December 2018
33 Reads

Progestogen for preventing miscarriage in women with recurrent miscarriage of unclear etiology.

Cochrane Database Syst Rev 2018 10 8;10:CD003511. Epub 2018 Oct 8.

Department of Obstetrics and Gynecology, Indiana University School of Medicine, 1001 West 10th Street, F-5, Indianapolis, Indiana, USA, 46202.

Background: Progesterone, a female sex hormone, is known to induce secretory changes in the lining of the uterus essential for successful implantation of a fertilized egg. It has been suggested that a causative factor in many cases of miscarriage may be inadequate secretion of progesterone. Therefore, clinicians use progestogens (drugs that interact with the progesterone receptors), beginning in the first trimester of pregnancy, in an attempt to prevent spontaneous miscarriage. Read More

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http://doi.wiley.com/10.1002/14651858.CD003511.pub4
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http://dx.doi.org/10.1002/14651858.CD003511.pub4DOI Listing
October 2018
9 Reads

The association of polymorphisms in promoter region of MMP2 and MMP9 with recurrent spontaneous abortion risk in Chinese population.

Medicine (Baltimore) 2018 Oct;97(40):e12561

Department of Obstetrics and Gynecology, First Affiliate Hospital of Jinan University.

This study aimed to reveal the genetic association between polymorphisms in promoter region of matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MMP9) and the risk of recurrent spontaneous abortion (RSA) in Chinese population.A total of 129 RSA patients and 116 relative controls were selected and the genotyping of polymorphism was conducted by polymerase chain reaction with sequencing. Genotype distribution of polymorphism in the control group was tested the status of Hardy-Weinberg equilibrium and then, genotype frequencies were compared between the case and control groups by chi-squared test. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810050-0003
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http://dx.doi.org/10.1097/MD.0000000000012561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200545PMC
October 2018
14 Reads
5.720 Impact Factor

Expression of Tim-3 in peripheral blood mononuclear cells and placental tissue in unexplained recurrent spontaneous abortion.

Medicine (Baltimore) 2018 Sep;97(38):e12099

Department of Clinical Laboratory Medicine, Shandong University Qilu Hospital.

The expression of T-cell immunoglobulin domain, mucin domain-3 (Tim-3) in unexplained recurrent spontaneous abortion (URSA) was investigated.Tim-3 mRNA expression in peripheral blood mononuclear cells (PBMCs) of URSA and control groups was assayed by fluorescent quantitative real-time polymerase chain reaction. Tim-3 protein expression intensity and localization in placental villi and uterine decidua were determined using immunohistochemical assay. Read More

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http://dx.doi.org/10.1097/MD.0000000000012099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160093PMC
September 2018
6 Reads
5.720 Impact Factor