8,303 results match your criteria Recurrent Early Pregnancy Loss


Recombinant human granulocyte- colony stimulating factor in women with unexplained recurrent pregnancy losses: a randomized clinical trial.

Hum Reprod 2019 Feb 18. Epub 2019 Feb 18.

Nora Therapeutics, Inc., 530 Lytton Avenue, 2nd Floor, Palo Alto, CA, USA.

Study Question: Does administration of recombinant human granulocyte colony stimulating factor (rhG-CSF) in the first trimester improve pregnancy outcomes, among women with a history of unexplained recurrent pregnancy loss?

Summary Answer: rhG-CSF administered in the first trimester of pregnancy did not improve outcomes among women with a history of unexplained recurrent pregnancy loss.

What Is Known Already: The only previous randomized controlled study of granulocyte colony stimulating factor in recurrent miscarriage in 68 women with unexplained primary recurrent miscarriage found a statistically significant reduction in miscarriage and improvement in live birth rates. A further four observational studies where G-CSF was used in a recurrent miscarriage population were identified in the literature, two of which confirmed statistically significant increase in clinical pregnancy and live birth rates. Read More

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http://dx.doi.org/10.1093/humrep/dey393DOI Listing
February 2019

Decidual RANKL/RANK interaction promotes the residence and polarization of TGF-β1-producing regulatory γδ T cells.

Cell Death Dis 2019 Feb 8;10(2):113. Epub 2019 Feb 8.

Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, 200011, Shanghai, People's Republic of China.

Abstact: Decidual γδΤ (dγδΤ) cells play an essential role during successful pregnancy; however, the residence and polarization of γδΤ cells in decidua remain unclear. In this study, we observed higher levels of receptor activator for nuclear factor-κ B ligand (RANKL) on decidual stromal cells (DSCs), and its receptor RANK on dγδΤ cells in decidua from normal pregnancy compared with patients with recurrent spontaneous abortion (RSA). RANKL expressed by DSCs can induce the polarization of peripheral blood γδΤ (pγδΤ) and dγδΤ cells to Foxp3 + γδΤ cells, and upregulate the expression of transforming growth factor (TGF)-β1. Read More

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http://dx.doi.org/10.1038/s41419-019-1380-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368618PMC
February 2019
1 Read

Transabdominal cerclage for cervical insufficiency in twins: series of seven cases and literature review.

J Matern Fetal Neonatal Med 2019 Feb 5:1-11. Epub 2019 Feb 5.

a Obstetrics Department , Cliniques Universitaires Saint Luc , Brussels , Belgium.

Background: The diagnosis of cervical insufficiency is based on previous history of recurrent second or early third trimester losses. Its incidence among pregnant women is 0,5-1%, but can be as high as 75% among women with preterm birth. Transvaginal cerclage (TVC) is the common therapy of cervical insufficiency. Read More

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http://dx.doi.org/10.1080/14767058.2019.1579192DOI Listing
February 2019
2 Reads

Risk markers of reproductive loss in women with hyperandrogenism.

Wiad Lek 2018 ;71(8):1550-1553

Ukrainian Medical Stomatological Academy, Poltava, Ukraine.

Objective: Introduction: The frequency of the pathological course of pregnancy with hyperandrogenism ranges from 21 to 48%. With the predominance of androgens against the background of lowering the normal products of steroidogenesis, a pro-inflammatory immune imbalance is formed, which causes a premature termination of the development of pregnancy. Many studies indicate that hyperandrogenism is a factor in the development of obstetric pathology, including placental dysfunction. Read More

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January 2018
7 Reads

Gene polymorphism associated with endothelial nitric oxide synthase (4VNTR, G894T, C786T) and unexplained recurrent spontaneous abortion risk: A meta-analysis.

Medicine (Baltimore) 2019 Jan;98(4):e14175

Department of First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.

To evaluate the association between endothelial nitric oxide synthase gene polymorphisms (4VNTR A/B, G894T, C786T) and risk of URSA.Related case-control studies were collected by computers. A meta-analysis was conducted using Stata 12. Read More

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http://dx.doi.org/10.1097/MD.0000000000014175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358376PMC
January 2019
4 Reads

Preimplantation genetic diagnosis in early pregnancy loss.

Semin Perinatol 2018 Dec 20. Epub 2018 Dec 20.

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Columbia University Medical Center, 5 Columbus Circle, PH New York, NY 10019, USA.

Miscarriage is a frequent outcome seen in obstetrics with 1 in 5 pregnancies ending in an early pregnancy loss. Aneuploidy is the most significant single factor affecting early pregnancy failure and miscarriage. The risk of aneuploidy increases significantly with increasing maternal age. Read More

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http://dx.doi.org/10.1053/j.semperi.2018.12.009DOI Listing
December 2018
3 Reads

Correction: PreImplantation factor (PIF) protects cultured embryos against oxidative stress: relevance for recurrent pregnancy loss (RPL) therapy.

Oncotarget 2018 Dec 18;9(99):37344. Epub 2018 Dec 18.

Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

[This corrects the article DOI: 10.18632/oncotarget.16028. Read More

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http://dx.doi.org/10.18632/oncotarget.26505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324672PMC
December 2018
1 Read

[Effect of occupational stress on recurrent spontaneous abortion in women of childbearing age].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Nov;36(11):840-843

Institute of Research Center, Gansu Provincial Maternity and Child-care Hospital, Lanzhou 730030, China.

To investigate the influence of occupational stress on recurrent spontaneous abortion (RSA) in women of childbearing age. From January to December, 2017, 75 working women of childbearing age (25-35 years) who were admitted to a provisional hospital in Lanzhou, China and diagnosed with RSA were assigned into patient group. At a 1∶4 ratio, 300 age-matched working women who had normal first pregnancy were randomly selected as controls. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2018.11.011DOI Listing
November 2018
6 Reads

Involvement of ILR4α and TLR4 in miscarriages.

J Reprod Immunol 2019 Feb 8;131:36-43. Epub 2019 Jan 8.

Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.

Background: The purpose of this study was to analyze the involvement of signaling via Interleukin-4-Receptor α (IL4Rα) and Toll like receptor (TLR) 4 at the fetomaternal interface in the process of early pregnancy.

Patients And Methods: Placenta specimens of 46 patients in early pregnancy were analyzed (normal pregnancy (n = 15), spontaneous (n = 15) and habitual abortion (n = 16)). TLR4 and IL4Rα were analyzed by immunohistochemistry, immunofluorescence and real time PCR. Read More

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http://dx.doi.org/10.1016/j.jri.2018.12.001DOI Listing
February 2019
2 Reads
2.815 Impact Factor

Risk factors for miscarriage among women attending an early pregnancy assessment unit (EPAU): a prospective cohort study.

Ir J Med Sci 2019 Jan 3. Epub 2019 Jan 3.

Pregnancy Loss Research Group, Department of Obstetrics and Gynaecology, University College Cork, Cork, Ireland.

Background: Miscarriage is the most common adverse outcome in early pregnancy; however, high proportion of miscarriages are classified as unexplained. In addition, pregnant women attending early pregnancy assessment units might be more vulnerable.

Aims: The purpose of this study was to explore the risk factors that might be associated with miscarriage among women attending an early pregnancy assessment unit (EPAU). Read More

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http://link.springer.com/10.1007/s11845-018-1955-2
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http://dx.doi.org/10.1007/s11845-018-1955-2DOI Listing
January 2019
5 Reads

The Effect of Low Molecular Weight Heparin in Recurrent Pregnancy Loss: Changes in Radial Uterine Artery Blood Flow and Peripheral Blood NK Cell Fraction.

Egypt J Immunol 2018 Jun;25(2):75-85

Embaba general hospital, Cairo, Egypt.

Immunological alteration has been suggested as a cause of unexplained early recurrent pregnancy loss (RPL). Natural killers (NKs) have been reported to play a role in vascular remodeling of decidual vessels. We aimed to find out if there is a relationship between peripheral blood NKs (pbNKs) and uterine radial artery (uRA) blood flow, and if low molecular weight heparin (LMWH) is effective in improving uRA blood flow in RPL cases and pregnancy outcome. Read More

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June 2018
7 Reads

[Comparison of the etiological constitution of two and three or more recurrent miscarriage].

Zhonghua Fu Chan Ke Za Zhi 2018 Dec;53(12):855-859

Center for Reproductive Medicine, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

To compare the etiological constitution of recurrent miscarriage (RM) between patients with consecutive two and three or more miscarriages through combining the routine examination results and embryonic karyotype. Patients with a history of two or more consecutive clinical miscarriages (≤12 weeks of gestation) consulting in the RM clinic of the First Affiliated Hospital of Sun Yat-sen University from March 2011 to January 2016 were collected. Six hundred and ninety-six with detailed history recorded, routine clinical examinations of RM and at least once embryonic karyotype were ultimately enrolled in this study. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2018.12.010DOI Listing
December 2018
2 Reads

Efficacy of Antenatal Intravenous Immunoglobulin Treatment in Pregnancies at High Risk due to Alloimmunization to Red Blood Cells.

Transfus Med Hemother 2018 Nov 31;45(6):429-436. Epub 2018 Oct 31.

Department of Gynecology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany.

Background: Alloimmunization to red blood cells (RBCs) may result in fetal anemia prior to 20 weeks gestation. The question as to whether early commencement of antenatal treatment with high-dose intravenous immunoglobulins (IVIG) may prevent or at least delay the development of fetal anemia in the presence of alloantibodies to RBCs is highly relevant.

Patients And Results: Here we describe a patient with high-titer anti-K and two other severely affected pregnant women with a history of recurrent pregnancy loss due to high-titer anti-D or anti-D plus anti-C. Read More

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http://dx.doi.org/10.1159/000490154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288630PMC
November 2018
1 Read

Anti-nociceptive and anti-inflammatory potentials of Akebia saponin D.

Eur J Pharmacol 2019 Feb 1;845:85-90. Epub 2018 Dec 1.

Beijing Chao-Yang Hospital Affiliated with Beijing Capital Medical University, Beijing, China. Electronic address:

Akebia saponin D, which is originates from Dipsacus asper Wall, has been used as a tonic, an analgesic and anti-inflammatory agent for the therapy of low back pain, rheumatic arthritis, traumatic hematoma, habitual abortion and bone fractures in traditional Chinese medicine. However, the anti-nociceptive and anti-inflammatory activity and mechanism of Akebia saponin D has been rarely reported. The aim of this study was to investigate the anti-nociceptive and anti-inflammatory activity of Akebia saponin D and to assess its possible mechanism. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00142999183069
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http://dx.doi.org/10.1016/j.ejphar.2018.11.038DOI Listing
February 2019
12 Reads

The role of the PD-1/PD-L1 axis in macrophage differentiation and function during pregnancy.

Hum Reprod 2019 Jan;34(1):25-36

Family Planning Research Institute, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.

Study Question: What is the role of the programmed cell death-1 (PD-1)/PD-1 ligand-1 (PD-L1) axis in macrophage polarization during early pregnancy?

Summary Answer: PD-1 signaling is a major regulator of macrophage differentiation and function, and it is critical for the success of a pregnancy.

What Is Known Already: The predominance of decidual macrophages (DMs) with an M2 phenotype is an important contributor to maternal-fetal tolerance during early pregnancy.

Study Design, Size, Duration: Twenty-four women with recurrent miscarriage (RM) and 70 women undergoing elective termination of an early normal pregnancy (NP) were included. Read More

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http://dx.doi.org/10.1093/humrep/dey347DOI Listing
January 2019
2 Reads

Antiphospholipid syndrome in obstetrics.

Authors:
M Kemp W Thomas

Lupus 2018 Oct;27(1_suppl):28-31

2 Department of Haematology, Haemophilia & Thrombophilia Centre, Addenbrooke's Hospital, Cambridge, UK.

Antiphospholipid syndrome (APS) covers a spectrum of clinical manifestations ranging from recurrent pregnancy loss and obstetric complications from placental dysfunction through to thrombotic disease. This article will focus on the common manifestations of the pregnancy-related complications of APS. This includes clinical manifestations, diagnosis and management, as general practitioners will need to be able to recognize the disorder and will also have patients under their care receiving treatment for APS. Read More

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http://dx.doi.org/10.1177/0961203318801664DOI Listing
October 2018
4 Reads

The relationship between sperm DNA fragmentation, free radicals and antioxidant capacity with idiopathic repeated pregnancy loss.

Reprod Biol 2018 Dec 14;18(4):330-335. Epub 2018 Nov 14.

Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, P.O. Box: 16635-148, Tehran, Iran. Electronic address:

More than two consecutive miscarriages in less than 20 weeks of gestation is defined as recurrent spontaneous miscarriage. Various causes such as uterine anatomical anomalies, genetic factors, and infectious and endocrine disorders have been reported for RPL. However, approximately 50% of the causes are unknown, which can be due to male factors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1642431X183015
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http://dx.doi.org/10.1016/j.repbio.2018.11.002DOI Listing
December 2018
11 Reads

Cytogenetic screening in couples with Habitual Abortions.

J Gynecol Obstet Hum Reprod 2018 Nov 6. Epub 2018 Nov 6.

Harran University, Faculty of Medicine, Department of Obstetrics and Gynecology, Sanliurfa, Turkey.

Objective: Habitual abortion (HA) is defined at least three consecutive pregnancy losses. One of the etiologic causes is parental chromosomal anomalies. In this study, we aimed to that investigate the effect of parental chromosomal abnormalities on HA. Read More

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http://dx.doi.org/10.1016/j.jogoh.2018.10.021DOI Listing
November 2018
1 Read

The role of three-dimensional ultrasound in pregnancies submitted to cerclage.

Rev Assoc Med Bras (1992) 2018 Jul;64(7):620-626

Department of Obstetrics and Gynaecology, São Paulo University School of Medicine, São Paulo - SP, Brasil.

Objective: Cervical cerclage is the standard treatment for cervical incompetence (CI); however, there is still a high risk of preterm birth for women who undergo this treatment. The aim of this study was to longitudinally evaluate findings on two-dimensional transvaginal ultrasonography (2DTVUS) and three-dimensional transvaginal ultrasonography (3DTVUS) that could be related to gestational age at birth.

Methods: A total of 68 pregnant women who were treated with cerclage were evaluated by 2DTVUS and 3DTVUS in the second and third trimesters of pregnancy. Read More

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http://dx.doi.org/10.1590/1806-9282.64.07.620DOI Listing
July 2018
1 Read

[The Analysis of Actual Approaches in Evaluating Efficiency of Medical Care of Female Patients with Habitual Miscarriage].

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2018 Jul;26(4):236-239

The State Budget Institution of Health Care "The M.P. Konchalovsky State Clinical Hospital" of the Moscow Health Care Department, Moscow, 124489, Russia.

The prevalence of habitual miscarriage varies depending on territories of the Russian Federation and other countries. The rate of premature delivery in the Moscow Zelenograd administrative okrug in 2013-2015 in average made up to 4.5%-4. Read More

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http://dx.doi.org/10.32687/0869-866X-2018-26-4-236-239DOI Listing
July 2018
4 Reads

Obstetric antiphospholipid syndrome.

Lupus Sci Med 2018 25;5(1):e000197. Epub 2018 Sep 25.

Unit of Rheumatology, Department of Medicine, Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

The present clinical and laboratory classification criteria for antiphospholipid syndrome (APS) were established in Sydney, Australia, in 2006. In this review, we focus on the obstetric subset of APS (OAPS), defined by persistent positivity for antiphospholipid antibodies together with either early recurrent pregnancy loss, early fetal death, stillbirth or premature birth <34 gestational weeks due to pre-eclampsia, eclampsia and placental insufficiency. It is important to diagnose these cases since most women suffering from OAPS can, when given appropriate treatment, have successful pregnancies. Read More

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http://dx.doi.org/10.1136/lupus-2016-000197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195166PMC
September 2018
18 Reads

Opposing roles of inter-α-trypsin inhibitor heavy chain 4 in recurrent pregnancy loss.

EBioMedicine 2018 Nov 19;37:535-546. Epub 2018 Oct 19.

Department of Biomedical Science, CHA University, CHA General Hospital, Gyeonggi-Do 463-400, Republic of Korea. Electronic address:

Background: The mechanism behind an increased risk of recurrent pregnancy loss (RPL) remains largely unknown. In our previous study, we identified that inter-α-trypsin inhibitor heavy chain 4 (ITI-H4) is highly expressed at a modified molecular weight of 36 kDa in serum derived from RPL patients. Yet, the precise molecular mechanism and pathways by which the short form of ITI-H4 carries out its function remain obscure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183044
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http://dx.doi.org/10.1016/j.ebiom.2018.10.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286651PMC
November 2018
11 Reads

CAPS Mutations Are Potentially Associated with Unexplained Recurrent Pregnancy Loss.

Am J Pathol 2019 Jan 17;189(1):124-131. Epub 2018 Oct 17.

Graduate School of Peking Union Medical College, Beijing, China; Center for Genetics, National Research Institute for Family Planning, Beijing, China.

Recurrent pregnancy loss (RPL) is a major concern for women's reproductive health. Several studies have proved that genetics is a major factor leading to unexplained RPL, but the maternal pathogenic genes involved in RPL remain largely unknown. A consanguineous family, including the parents who were cousins and their three daughters who had been diagnosed as having nonsyndromic unexplained RPL, was recruited in this study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029440183038
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http://dx.doi.org/10.1016/j.ajpath.2018.09.010DOI Listing
January 2019
14 Reads

Correlation between CTLA4 genetic polymorphisms, its serum protein level and the susceptibility to recurrent spontaneous abortion: A case-control study.

Medicine (Baltimore) 2018 Oct;97(42):e12754

Department of Obstetrics and Gynecology, First Affiliate Hospital of Jinan University.

Present study was aimed to detect the influence of cytotoxic T-lymphocyte associated protein 4 (CTLA4) gene polymorphisms for the risk of recurrent spontaneous abortion (RSA), as well as the serum level of CTLA4 protein in RSA patients.One hundred thirty-three RSA patients and 146 healthy persons were recruited in this case-control study. PCR-RFLP was used to genotype the CTLA4 gene polymorphisms both in case and control groups. Read More

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http://dx.doi.org/10.1097/MD.0000000000012754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211885PMC
October 2018
16 Reads
5.720 Impact Factor

New insights into the mechanisms underlying recurrent pregnancy loss.

J Obstet Gynaecol Res 2019 Feb 16;45(2):258-265. Epub 2018 Oct 16.

Division of Biomedical Sciences, Clinical Science Research Laboratories, Warwick Medical School, University of Warwick, Coventry, UK.

Recurrent pregnancy loss (RPL), defined as multiple consecutive miscarriages, is a devastating disorder for which there are no good treatment options. Two opposing paradigms have emerged to explain RPL. The prevailing clinical viewpoint is that RPL is caused by a spectrum of subclinical disorders, ranging from thrombophilia to anatomical, endocrine and immunological disorders, that somehow converge on a 'fragile' early pregnancy state, leading to miscarriage. Read More

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http://doi.wiley.com/10.1111/jog.13837
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http://dx.doi.org/10.1111/jog.13837DOI Listing
February 2019
13 Reads

Advances in the management of early pregnancy loss.

Curr Opin Obstet Gynecol 2018 Dec;30(6):419-424

Division of Family Planning Services & Research, Department of Obstetrics & Gynecology, Stanford University, Stanford, California, USA.

Purpose Of Review: To describe recent advances in management of early pregnancy loss.

Recent Findings: Addition of mifepristone to current protocols for medical management of miscarriage increases effectiveness of a single dose of misoprostol and significantly reduces subsequent aspiration procedures. Women with an incomplete evacuation after medical management may be treated expectantly with similar rates of complete expulsion compared with surgical management at 6 weeks. Read More

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http://Insights.ovid.com/crossref?an=00001703-900000000-9929
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http://dx.doi.org/10.1097/GCO.0000000000000501DOI Listing
December 2018
26 Reads

Progestogen for preventing miscarriage in women with recurrent miscarriage of unclear etiology.

Cochrane Database Syst Rev 2018 10 8;10:CD003511. Epub 2018 Oct 8.

Department of Obstetrics and Gynecology, Indiana University School of Medicine, 1001 West 10th Street, F-5, Indianapolis, Indiana, USA, 46202.

Background: Progesterone, a female sex hormone, is known to induce secretory changes in the lining of the uterus essential for successful implantation of a fertilized egg. It has been suggested that a causative factor in many cases of miscarriage may be inadequate secretion of progesterone. Therefore, clinicians use progestogens (drugs that interact with the progesterone receptors), beginning in the first trimester of pregnancy, in an attempt to prevent spontaneous miscarriage. Read More

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http://doi.wiley.com/10.1002/14651858.CD003511.pub4
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http://dx.doi.org/10.1002/14651858.CD003511.pub4DOI Listing
October 2018
7 Reads

The association of polymorphisms in promoter region of MMP2 and MMP9 with recurrent spontaneous abortion risk in Chinese population.

Medicine (Baltimore) 2018 Oct;97(40):e12561

Department of Obstetrics and Gynecology, First Affiliate Hospital of Jinan University.

This study aimed to reveal the genetic association between polymorphisms in promoter region of matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MMP9) and the risk of recurrent spontaneous abortion (RSA) in Chinese population.A total of 129 RSA patients and 116 relative controls were selected and the genotyping of polymorphism was conducted by polymerase chain reaction with sequencing. Genotype distribution of polymorphism in the control group was tested the status of Hardy-Weinberg equilibrium and then, genotype frequencies were compared between the case and control groups by chi-squared test. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810050-0003
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http://dx.doi.org/10.1097/MD.0000000000012561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200545PMC
October 2018
12 Reads
5.720 Impact Factor

Expression of Tim-3 in peripheral blood mononuclear cells and placental tissue in unexplained recurrent spontaneous abortion.

Medicine (Baltimore) 2018 Sep;97(38):e12099

Department of Clinical Laboratory Medicine, Shandong University Qilu Hospital.

The expression of T-cell immunoglobulin domain, mucin domain-3 (Tim-3) in unexplained recurrent spontaneous abortion (URSA) was investigated.Tim-3 mRNA expression in peripheral blood mononuclear cells (PBMCs) of URSA and control groups was assayed by fluorescent quantitative real-time polymerase chain reaction. Tim-3 protein expression intensity and localization in placental villi and uterine decidua were determined using immunohistochemical assay. Read More

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http://dx.doi.org/10.1097/MD.0000000000012099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160093PMC
September 2018
3 Reads
5.720 Impact Factor

Connecting links between genetic factors defining ovarian reserve and recurrent miscarriages.

J Assist Reprod Genet 2018 Dec 15;35(12):2121-2128. Epub 2018 Sep 15.

Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, U.P., 226014, India.

Purpose: Approximately 1-2% of the women faces three or more successive spontaneous miscarriages termed as recurrent miscarriage (RM). Many clinical factors have been attributed so far to be the potential risk factors in RM, including uterine anomalies, antiphospholipid syndrome, endocrinological abnormalities, chromosomal abnormalities, and infections. However, in spite of extensive studies, reviews, and array of causes known to be associated with RM, about 50% cases encountered by treating physicians remains unknown. Read More

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http://link.springer.com/10.1007/s10815-018-1305-3
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http://dx.doi.org/10.1007/s10815-018-1305-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289926PMC
December 2018
15 Reads

Women with Recurrent Pregnancy Loss : Their Psychology During Late Pregnancy and the Supportive Behavior of Their Partners.

Acta Med Okayama 2018 Aug;72(4):387-394

Department of Nursing, Faculty of Health and Welfare, Kawasaki University of Medical Welfare, Kurashiki, Okayama 701-0193,

To elucidate the psychiatric characteristics of mothers and the supportive behavior of their partners during late pregnancy, 131 mothers who gave birth at 2 general hospitals in City A between August 2009 and September 2010 (control group: n=90; recurrent pregnancy loss (RPL) group: n=41) completed a self-administered questionnaire on four separate occasions: during late pregnancy, during hospitalization, at 1-month postpartum, and at 3-months postpartum. The RPL group had significantly (p=0.03) lower anxiety regarding potential change in their appearance than the controls, but were more likely to worry about losing their baby (58% vs. Read More

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http://dx.doi.org/10.18926/AMO/56176DOI Listing
August 2018
14 Reads

[Relationship between inflammatory indexes of amniotic fluid and pregnancy outcome of women with cervical incompetence].

Zhonghua Fu Chan Ke Za Zhi 2018 Aug;53(8):517-521

Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China.

To investigate the relationship between the level of amniotic fluid inflammatory factor and the pregnancy outcome in patients with cervical incompetence. A retrospective case-control study was conducted. Totally 110 cases of pregnant women were diagnosed as cervical incompetence for cervical dilation at the medical examination in Sun Yat-sen Memorial Hospital of Sun Yatsen University, from January 1st, 2015 to December 31th, 2016. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2018.08.002DOI Listing
August 2018
9 Reads

Elevated percentage of CD3T cells and pregnancy outcome in women with recurrent pregnancy loss.

Clin Chim Acta 2018 Nov 18;486:341-346. Epub 2018 Aug 18.

Department of Reproductive Immunology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China. Electronic address:

Background: Even though the immune factor is not yet established as a cause of recurrent pregnancy loss (RPL), tons of other studies have shown that a significant proportion of immune abnormalities exist in RPL.

Methods: We conducted a retrospective cohort study with 850 women who were diagnosed with RPL. The percentages of CD3, CD3CD4 and CD3CD8T cells of each participant, detected by flow cytometry, were obtained before pregnancy and at 6 weeks of gestation as part of their routine medical examination. Read More

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http://dx.doi.org/10.1016/j.cca.2018.08.024DOI Listing
November 2018
17 Reads

Integrated analysis of DNA methylome and transcriptome identified CREB5 as a novel risk gene contributing to recurrent pregnancy loss.

EBioMedicine 2018 Sep 10;35:334-344. Epub 2018 Aug 10.

State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, China. Electronic address:

Background: Aberrant DNA methylation is considered to be a potential cause of recurrent pregnancy loss (RPL), while potential mechanism has not yet been elucidated.

Methods: In order to uncover the contribution of the perturbation of DNA methylation in RPL, we performed genome-wide DNA methylation analysis combined with genome-wide gene expression in decidua tissue.

Findings: Totally, 539 differentially methylated regions (DMRs) were identified and significantly correlated with gene expressions. Read More

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http://dx.doi.org/10.1016/j.ebiom.2018.07.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154871PMC
September 2018
8 Reads

Maternal antithyroid antibodies and euploid miscarriage in women with recurrent early pregnancy loss.

Fertil Steril 2018 08;110(3):452-458

Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois. Electronic address:

Objective: To determine whether an association exists between maternal antithyroid antibodies and euploid miscarriage in women with recurrent early pregnancy loss (REPL).

Design: Observational cohort study.

Setting: Two academic medical centers. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2018.04.026DOI Listing
August 2018
12 Reads

Association of genetic polymorphisms in VEGF -460, -7 and -583 and hematocrit level with the development of idiopathic recurrent pregnancy loss and a meta-analysis.

J Gene Med 2018 Sep 30;20(9):e3048. Epub 2018 Aug 30.

Department of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.

Background: The present study was performed to investigate whether genetic variants of VEGF are associated with recurrent pregnancy loss (RPL) in Korean women and to provide insight into the role of VEGF in the pathogenesis of RPL development.

Methods: A cohort of 384 women with idiopathic RPL with a history of two or more uxexplained consecutive early pregnancy losses and 236 control women were recruited from an infertility center of university-teaching hospital in Korea between March 1999 and February 2010. We examined three VEGF polymorphisms (rs833061, rs3025020 and rs25648). Read More

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http://dx.doi.org/10.1002/jgm.3048DOI Listing
September 2018
4 Reads

Quality of life and psychological distress in women with recurrent miscarriage: a comparative study.

Health Qual Life Outcomes 2018 Jul 28;16(1):150. Epub 2018 Jul 28.

Population Health Research Group, Health Metrics Research Centre, Iranian Institute for Health Sciences Research, ACECR, Tehran, Iran.

Background: This study aimed to evaluate quality of life and psychological distress in Iranian women with recurrent miscarriage and to compare it in women without miscarriage.

Methods: This was a comparative study of quality of life among women with and without recurrent miscarriage. Cases were selected from patients with complain of recurrent miscarriage and comparison group were selected from women attending to two teaching hospitals for annual screening. Read More

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http://dx.doi.org/10.1186/s12955-018-0982-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064101PMC
July 2018
5 Reads
2.120 Impact Factor

Recurrent pregnancy loss and vitamin D: A review of the literature.

Am J Reprod Immunol 2018 Nov 27;80(5):e13022. Epub 2018 Jul 27.

UMIB, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal.

Recurrent pregnancy loss (RPL) affects approximately 1%-2% of reproductive women. Auto- and cellular immune responses seem to be associated with RPL. Vitamin D (VD) has been shown to play a role in the modulation of the immune system. Read More

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http://dx.doi.org/10.1111/aji.13022DOI Listing
November 2018
18 Reads

[Hydroxychloroquine to obtain pregnancy without adverse obstetrical events in primary antiphospholipid syndrome: French phase II multicenter randomized trial, HYDROSAPL].

Gynecol Obstet Fertil Senol 2018 Jul - Aug;46(7-8):598-604. Epub 2018 Jun 29.

Service de médecine interne et Inflammation-Immunopathology-Biotherapy Department (DHU i2B), hôpital Saint-Antoine, faculté de médecine Sorbonne université, AP-HP, 75012 Paris, France; Département hospitalo-universitaire inflammation-immunopathologie-biothérapie (DHU i2B), UPMC université Paris 06, UMR 7211, Sorbonne universités, 75005 Paris, France.

Antiphospholipid syndrome is defined by the presence of thrombosis and/or obstetrical adverse events (≥3 recurrent early miscarriage or fetal death or a prematurity<34 weeks of gestation) associated with persistent antiphospholipid antibodies. The pregnancy outcome has been improved by the conventional treatment (aspirin 100mg/day with low molecular weight heparin [LMWH] from 30 to 75% of uncomplicated pregnancies. In PROMISSE study, 19% of pregnancies had at least one obstetrical adverse event despite treatment (maternal, fetal or neonatal complications) in relation with APS. Read More

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http://dx.doi.org/10.1016/j.gofs.2018.06.008DOI Listing
December 2018
3 Reads

Tokishakuyakusan, a traditional Japanese medicine (Kampo) mitigates iNKT cell-mediated pregnancy loss in mice.

Am J Reprod Immunol 2018 Oct 12;80(4):e13021. Epub 2018 Jul 12.

Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Objective: Tokishakuyakusan (TSS) is a traditional herbal medicine that has been used empirically to prevent recurrent pregnancy loss. Its mode of action remains unclear. With their potent capacity to produce cytokines, invariant natural killer (iNKT) cells are involved in the control of fetomaternal immunity in early gestation. Read More

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http://dx.doi.org/10.1111/aji.13021DOI Listing
October 2018
5 Reads

Laparoscopic cervico-isthmic cerclage: About 25 cases.

J Gynecol Obstet Hum Reprod 2018 Oct 7;47(8):385-389. Epub 2018 Jul 7.

CHU Clermont-Ferrand, 1, place Lucie et Raymond Aubrac, 63100 Clermont-Ferrand cedex 1, France.

Introduction: The purpose of this study is to report on our experience of laparoscopic cervico-isthmic cerclage.

Material And Method: A monocentric retrospective study covering a 13-year period during which 25 cases of laparoscopic cerclage outside of pregnancy were performed, using the technique described by Dubuisson, at the University Hospital of Clermont-Ferrand. Individual patient data included pregnancy outcomes before and after cerclage and the characteristics of surgery. Read More

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http://dx.doi.org/10.1016/j.jogoh.2018.07.002DOI Listing
October 2018
1 Read

Re: Three-dimensional ultrasound imaging of intra-abdominal cervical-isthmus cerclage.

Ultrasound Obstet Gynecol 2018 07;52(1):124-125

Department of Obstetrics and Gynecology, Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris (APHP), 94275, Le Kremlin-Bicêtre, France.

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http://dx.doi.org/10.1002/uog.19088DOI Listing
July 2018
1 Read

The association between cardiovascular disease gene mutations and recurrent pregnancy loss in the Lebanese population.

Mol Biol Rep 2018 Oct 4;45(5):911-916. Epub 2018 Jul 4.

Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Cairo Street, Beirut, Lebanon.

Recurrent pregnancy loss (RPL) is a problem affecting up to 5% of women of childbearing age due to many factors. Studies have shown that RPL and cardiovascular disease (CVD) may have shared risk factors. We compared the prevalence of 12 cardiovascular disease related gene mutations in patients with a history of RPL to normal controls in a major tertiary care center in Lebanon. Read More

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http://dx.doi.org/10.1007/s11033-018-4237-1DOI Listing
October 2018
4 Reads

Association of the peripheral blood levels of circulating microRNAs with both recurrent miscarriage and the outcomes of embryo transfer in an in vitro fertilization process.

J Transl Med 2018 Jul 4;16(1):186. Epub 2018 Jul 4.

Key Laboratory of Reproduction Regulation of NHFPC, Shanghai Institute of Planned Parenthood Research, Pharmacy School, Fudan University, Shanghai, China.

Background: Implantation failure is not only a major cause of early pregnancy loss, but it is also an obstacle to assisted reproductive technologies. The identification of potential circulating biomarkers for recurrent miscarriage (RM) and/or recurrent implantation failure would contribute to the development of novel diagnosis and prediction techniques.

Methods: MiR (miR-23a-3p, 27a-3p, 29a-3p, 100-5p, 127-3p and 486-5p) expression in the villi, decidual tissues and peripheral blood plasma and serum were validated by qPCR, and the localization of miRs in the villi and decidual tissues of RM and normal pregnancy (NP) women were detected by in situ hybridization. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-018-1556-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032771PMC
July 2018
22 Reads

Acetylsalicylic acid does not prevent first-trimester unexplained recurrent pregnancy loss: A randomized controlled trial.

Acta Obstet Gynecol Scand 2018 Nov 9;97(11):1365-1372. Epub 2018 Aug 9.

Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Introduction: Recurrent pregnancy loss occurs in about 1% of fertile couples. Without proper evidence for an effect, different treatments have been used when no etiological factor has been detected. The present trial is the first randomized trial to compare 75 mg acetylsalicylic acid with placebo for women with recurrent pregnancy loss. Read More

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http://dx.doi.org/10.1111/aogs.13420DOI Listing
November 2018
4 Reads

Perceived Subfecundity and Contraceptive Use Among Young Adult U.S. Women.

Authors:
Alison Gemmill

Perspect Sex Reprod Health 2018 09 3;50(3):119-127. Epub 2018 Jul 3.

Assistant professor in the Department of Family, Population and Preventive Medicine, and a core faculty member of the Program in Public Health, at Stony Brook University, Stony Brook, New York.

Context: Women who view themselves as having difficulty becoming pregnant (i.e., being subfecund) may feel that they do not need to use contraceptives to prevent unintended pregnancy. Read More

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http://dx.doi.org/10.1363/psrh.12072DOI Listing
September 2018
2 Reads

Association study of frameshift and splice variant polymorphisms with risk of idiopathic recurrent pregnancy loss.

Mol Med Rep 2018 Aug 21;18(2):2417-2426. Epub 2018 Jun 21.

Department of Biomedical Science, College of Life Science, CHA University, Seongnam, Gyeonggi 13488, Republic of Korea.

Recurrent pregnancy loss (RPL) is defined as ≥2 consecutive pregnancy losses, and can be caused by various factors, including genetics, chromosomal abnormalities, thrombophilia, immune disorders, nutritional factors, environmental factors, psychological stress or maternal infections; however, as many as 50% of RPL cases are idiopathic. In the present study, the role of genetic polymorphisms in RPL was investigated. Four gene polymorphisms were selected by whole exome sequencing, including membrane spanning 4‑domains A14 (MS4A14)D>I (rs3217518), solute carrier family 2 member 7 (SLC2A7)D>I (rs60746313), pregnancy specific β‑1‑glycoprotein 9 (PSG9)C>T (rs3746297) and ATP binding cassette subfamily B member 5 (ABCB5)C>G (rs17143187), and the aim was to investigate their association with RPL in Korean women. Read More

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http://dx.doi.org/10.3892/mmr.2018.9202DOI Listing
August 2018
5 Reads

PPARγ Expression Is Diminished in Macrophages of Recurrent Miscarriage Placentas.

Int J Mol Sci 2018 Jun 26;19(7). Epub 2018 Jun 26.

Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr. 15, 81377 Munich, Germany.

PPARγ belongs to the group of nuclear receptors which is expressed in the trophoblast and together with other factors is responsible for the maintenance of pregnancy. Apart from that PPARγ is also a main factor for macrophage polarization. The aim of this study was to investigate the combined expression pattern and frequency of PPARγ under physiological circumstances and in spontaneous and recurrent miscarriages in the trophoblast and in maternal macrophages of the decidua. Read More

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http://dx.doi.org/10.3390/ijms19071872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073463PMC
June 2018
11 Reads
2.862 Impact Factor