111,059 results match your criteria Rectal Prolapse


Racial Disparities in Incidence of Young-onset Colorectal Cancer and Patient Survival.

Gastroenterology 2018 Dec 3. Epub 2018 Dec 3.

Department of Epidemiology and Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Background & Aims: Increasing rates of young-onset colorectal cancer (CRC) have attracted substantial research and media attention, but we know little about racial disparities among younger adults with CRC. We examined racial disparities in young-onset CRC by comparing CRC incidence and relative survival among younger (age <50 years) adults, in 2 time periods.

Methods: Using data from the Surveillance, Epidemiology, and End Results program of cancer registries, we estimated CRC incidence rates (per 100,000 persons ages 20 - 54 years) from 1992 through 2014, for different time periods (1992-1996 vs 2010-2014) and races (white vs black). Read More

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December 2018
4 Reads

[Traumatic rectal lesions].

Ugeskr Laeger 2018 Dec;180(49)

Traumatic rectal lesions can be seen in both blunt and penetrating traumas and are associated with a high morbidity and high mortality. This is a review of the literature on diagnosis and treatment of intra- and extraperitoneal rectal lesions. There is a consensus, that intraperitoneal rectal lesions should be treated with primary repair alone. Read More

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December 2018

Physical response of dogs supplemented with fish oil during a treadmill training programme.

J Anim Physiol Anim Nutr (Berl) 2018 Dec 5. Epub 2018 Dec 5.

Laboratory of Veterinary Physiotherapy (LAFIVET), School of Veterinary Sciences (FCV), National University of La Plata (UNLP), Buenos Aires, Argentina.

The rise in popularity of dog sports competitions has led to the evaluation of improvements in dog physical performance. The potential benefit of dietary supplementation with fish oil (FO) on the physical performance of human beings and horses has been reported. However, such effect has not been studied in dogs. Read More

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December 2018

Institutional patient accrual volume and the treatment quality of I‑125 prostate seed implantation in a Japanese nationwide prospective cohort study.

Strahlenther Onkol 2018 Dec 5. Epub 2018 Dec 5.

Japanese Foundation for Prostate Research, Tokyo, Japan.

Purpose: It is unclear whether experience at high-volume institute improves the treatment quality of prostate seed implantation. The aim of this study was to evaluate the effect of institutional experience on postimplant dosimetric parameters in a nationwide prospective cohort study.

Methods: From July 2005 to June 2007, 2354 patients were registered in the Japanese Prostate Cancer Outcome Study of Permanent I‑125 Seed Implantation (J-POPS), and 1126 patients treated with seed implantation alone were evaluated. Read More

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December 2018
1 Read

A Nomogram Based on a TRUS Five-Grade Scoring System for the Prediction of Prostate Cancer and High Grade Prostate Cancer at Initial TRUS-Guided Biopsy.

J Cancer 2018 22;9(23):4382-4390. Epub 2018 Oct 22.

Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

: To evaluate the efficacy of transrectal ultrasound five-grade scoring system (TRUS-5) in predicting prostate cancer (PCa) and high grade PCa (HGPCa), compared with TRUS two-grade scoring system (TRUS-2), and establish a TRUS-5 based nomogram for the prediction of PCa and HGPCa at initial biopsy (IPBx). : Data were collected from 862 men who underwent initial TRUS-guided 12-core prostate biopsy. Age, prostate-specific antigen (PSA), percent free PSA, digital rectal examination (DRE), prostate volume (PV), PSA density (PSAD) and TRUS findings were included in the analysis. Read More

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October 2018
1 Read
2.639 Impact Factor

Prognostic Value of the Cycle Number of Perioperative Chemotherapy in Locoregionally Advanced Rectal Cancer: a Propensity Score Matching Analysis.

J Cancer 2018 21;9(23):4346-4354. Epub 2018 Oct 21.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center.

Appropriate cycle number of perioperative chemotherapy for patients with locoregionally advanced rectal cancer (LARC) remains unknown. This study aimed to evaluate how cycle number of perioperative chemotherapy influenced the prognosis of LARC patients. In this study, a total of 388 consecutive patients were enrolled and retrospectively reviewed if they were diagnosed with untreated stage cII-III LARC and treated with neoadjuvant chemoradiotherapy plus radical surgery followed by adjuvant chemotherapy or not. Read More

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October 2018

Multimodal Transgastric Local Pancreatic Hypothermia Reduces Severity of Acute Pancreatitis in Rats and Increases Survival.

Gastroenterology 2018 Oct 25. Epub 2018 Oct 25.

Department of Medicine, Mayo Clinic, Scottsdale, AZ. Electronic address:

Background & Aims: Acute pancreatitis (AP) of different etiologies is associated with activation of different signaling pathways in pancreatic cells, posing challenges to development of targeted therapies. We investigated whether local pancreatic hypothermia, without systemic hypothermia, can reduce severity of AP, induced by different methods in rats.

Methods: A urethane balloon, with two polyurethane tubes was placed inside the stomach of the rats. Read More

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October 2018

The conus medullaris ratio: A new way to identify tethered cord on MRI.

J Pediatr Surg 2018 Nov 6. Epub 2018 Nov 6.

Department of Radiology.

Purpose: Approximately 25% of patients with anorectal malformation have tethered cord. The traditional way of determining conus medullaris level on magnetic resonance imaging (MRI) relies on counting vertebrae, which may be challenging due to vertebral numeric variation, segmentation anomalies, as well as transitional vertebral body anatomy. The purpose of this study was to utilize more reliable anatomic landmarks (foramen magnum, conus termination, and the upper limit of the iliac crest) to establish a consistent ratio that may differentiate patients with normal and low-lying conus. Read More

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November 2018
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Do probiotics prevent colonization with multi-resistant Enterobacteriaceae during travel? A randomized controlled trial.

Travel Med Infect Dis 2018 Nov 30. Epub 2018 Nov 30.

Aarhus University Hospital, Department of Infectious Diseases, Aarhus, Denmark.

Background: Travelers to India are often colonized with extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) or Carbapenemase-producing Enterobacteriaceae (CPE). The aim of this study was to investigate if the probiotic species Lactobacillus Rhamnosus GG (LGG) could prevent the colonization of the gut with multi-drug resistant bacteria.

Methods: Adult Danish travelers traveling to India for 10-28 days were randomized to receive either LGG or no probiotics during travel. Read More

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November 2018

Consensus and controversies regarding follow-up after curative intent treatment of non-metastatic colorectal cancer: a synopsis of guidelines used in countries represented in ESCP.

Colorectal Dis 2018 Nov 30. Epub 2018 Nov 30.

Department of Surgery, Aarhus University Hospital, Aarhus, Denmark.

Aim: It is common clinical practice to follow patients for a period of years after curative intent treatment of non-metastatic colorectal cancer, but follow-up strategies vary widely. The aim of this systematic review was to provide an overview of recommendations in guidelines from ESCP member countries on this topic, with supporting evidence.

Methods: A systematic search of Medline, Embase and guidelines databases Tripdatabase, BMJ Best Practice and Guidelines International Network was performed. Read More

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November 2018
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Anal fistula plug versus rectal advancement flap for the treatment of complex cryptoglandular anal fistulas: a system review and meta-analysis of studies with long term follow-up.

Colorectal Dis 2018 Nov 30. Epub 2018 Nov 30.

Department of Intensive Care Unit, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Aim: To compare the effectiveness of the anal fistula plug (AFP) with the rectal advancement flap (RAF) for complex cryptoglandular anal fistulas.

Methods: We conducted a literature search to identify relevant available articles published without language restriction from EMBASE and PubMed databases and the Cochrane Library. Studies comparing outcomes with the AFP versus RAF for complex cryptoglandular anal fistulas were eligible for inclusion. Read More

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November 2018
3 Reads

[Transanal endoscopic microsurgery for local excision of rectal gastrointestinal stromal tumors].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1296-1300

Department of General Surgery, Peking Union Medical College Hospital, Beijing 100730, China.

Objective: To investigate the efficacy of transanal endoscopic microsurgery (TEM) combined with imatinib for rectal gastrointestinal stromal tumors(GIST).

Methods: Clinical data of 35 patients with rectal GIST undergoing TEM at Peking Union Medical College Hospital from February 2008 to May 2017 were analyzed retrospectively. Operation details, postoperative recovery condition, and follow-up information were reviewed. Read More

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November 2018

[Prognostic factors of patients with unresectable liver metastasis from colorectal cancer after failed conversion chemotherapy].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1261-1267

Department of Colorectal Surgery, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.

Objective: To explore the prognostic factors of patients with unresectable liver metastasis colorectal cancer after failed conversion chemotherapy.

Methods: A retrospective, case-controlled study was performed. Study subjects were 105 patients who were diagnosed with synchronous liver metastasis colorectal cancer after failed chemotherapy (metastasis evaluated as unresectable after the conversion chemotherapy) at Xinhua Hospital, Shanghai Jiaotong University from January 2012 to December 2015. Read More

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November 2018

[Effect of bladder training on bladder function recovery in the male patients after mid-low rectal cancer surgery: a prospective, open, randomized controlled study].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1255-1260

Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, China.

Objective: To investigate the efficacy and safety of the bladder training in male patients before urinary catheter removal after mid-low rectal cancer surgery.

Methods: This was a prospective, open, randomized controlled study.

Inclusion Criteria: male patients; pathologically diagnosed as mid-low rectal adenocarcinoma; distance from tumor lower edge to anal margin ≤10 cm; standard radical surgery for rectal cancer, including intestinal resection and regional lymph node dissection. Read More

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November 2018

[Long-term prognostic analysis on complete/near-complete clinical remission for mid-low rectal cancer after neoadjuvant chemoradiotherapy].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1240-1248

Department 3 of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital and Institute, Beijing 100142, China.Email:

Objective: To investigate the long-term outcome of organ preservation with local excision or "watch and wait" strategy for mid-low rectal cancer patients evaluated as clinical complete remission (cCR) or near-cCR following neoadjuvant chemoradiotherapy (NCRT).

Methods: Clinical data of 62 mid-low rectal cancer patients evaluated as cCR/near-cCR after NCRT undergoing organ preservation surgery with local excision or receiving "watch and wait" strategy at Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute from March 2011 to August 2017 were retrospectively analyzed. According to the approximate 1:2 pairing, 123 patients who underwent radical resection with complete pathological remission(ypCR) after neoadjuvant chemotherapy during the same period were selected for prognosis comparison. Read More

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November 2018
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Cell-free DNA and preoperative chemoradiotherapy for rectal cancer: a systematic review.

Clin Transl Oncol 2018 Dec 1. Epub 2018 Dec 1.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, 8000, Aarhus, Denmark.

Background: Preoperative chemoradiotherapy is the standard of care for patients with locally advanced rectal cancer, yet valid circulating biomarkers are lacking. We aimed at systematically reviewing the literature of cell-free DNA and locally advanced rectal cancer.

Methods: A systematic literature search was performed. Read More

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December 2018

Systematic review of outcomes following pelvic exenteration for the treatment of primary and recurrent locally advanced rectal cancer.

Tech Coloproctol 2018 Dec 1. Epub 2018 Dec 1.

Colorectal Unit, Derriford Hospital, Plymouth Hospital NHS Trust, Plymouth, UK.

Background: Pelvic exenteration represents the best treatment option for cure of locally advanced or recurrent rectal cancer. This systematic review sought to evaluate current literature regarding short and long term treatment outcomes and long term survival following pelvic exenteration.

Methods: A systematic search of the MEDLINE, PubMed and Ovid databases was conducted to identify suitable articles published between 2001 and 2016. Read More

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December 2018

The detection of the cytomegalovirus DNA in the colonic mucosa of patients with ulcerative colitis is associated with increased long-term risk of proctocolectomy: results from an outpatient IBD clinic.

Int J Colorectal Dis 2018 Nov 30. Epub 2018 Nov 30.

Internistische Gemeinschaftspraxis für Verdauungs- und Stoffwechselkrankheiten, Leipzig und Schkeuditz, Leipzig, Germany.

Purpose: Cytomegalovirus (CMV) infection has been found to be associated with a reactivation of ulcerative colitis (UC) and with an impaired response to medical therapy. In the past, only limited data were available on the long-term outcome for UC patients with positive tissue CMV-PCR in the colonic mucosa.

Methods: Between January 2010 and April 2015, we performed a qualitative PCR screening for CMV DNA in one biopsy from most actively inflamed rectal mucosa (tCMV-PCR). Read More

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November 2018
1 Read
2.449 Impact Factor

Increasing Pediatricians' Awareness of the Association between Anal Skin Tags and Earlier Diagnosis of Crohn's Disease.

Inflamm Intest Dis 2018 Nov 4;3(1):40-42. Epub 2018 Oct 4.

Department of Biostatistics, Lenox Hill Hospital, New York, New York, USA.

Objective: To seek the habits of pediatricians by which anorectal skin tags (AST) of Crohn's disease might be overlooked.

Methods: Questionnaires were sent to pediatricians affiliated with the Northwell Health System.

Results: Based on the responses, the majority of pediatricians did feel the abdomen of children presenting with abdominal pain or diarrhea but did not spread the buttocks to seek the presence of AST unless there was rectal pain, rectal bleeding, or, in some cases, loose stools. Read More

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November 2018
3 Reads

Prospective performance of the Prostate Health Index in prostate cancer detection in the first prostate biopsy of men with a total prostatic specific antigen of 4-10 ng/mL and negative digital rectal examination.

Prostate Int 2018 Dec 15;6(4):136-139. Epub 2018 Feb 15.

Division of Urology, Department of Surgery, Chiang Mai University, Chaing Mai, Thailand.

Background: The disadvantage of using total serum prostatic specific antigen (PSA) test for detection of prostate cancer is that it has a low specificity. The low specificity of total PSA (tPSA) test leads to unnecessary prostate biopsies. In this prospective study, we assessed the serum tPSA, free PSA, p2PSA, and the Prostate Health Index (PHI) in the detection of prostate cancer in men with a tPSA of 4-10 ng/mL and a negative digital rectal examination (DRE). Read More

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December 2018

Sexual dysfunction and infertility in the male spina bifida patient.

Transl Androl Urol 2018 Dec;7(6):941-949

Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA.

Spina bifida is a congenital neural tube defect with many neurological implications, as well as decreased sexual function and infertility. Few studies have directly investigated infertility in men with spina bifida. Infertility in this special patient population is primarily the result of spermatogenic defects and/or failure of sperm transport due to erectile or ejaculatory dysfunction. Read More

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December 2018

Use of rectal mucosal grafts in substitution urethroplasty: an early series.

Transl Androl Urol 2018 Dec;7(6):907-911

1Department of Urology, 2Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

Background: To evaluate the feasibility of use of rectal mucosal grafts for augmentation urethroplasty.

Methods: A series of five patients who underwent rectal mucosal graft urethroplasty for urethral stricture disease were identified. Descriptive statistics were used to describe these patients. Read More

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December 2018
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Predicting Pathological Complete Regression with Haematological Markers During Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer.

Anticancer Res 2018 Dec;38(12):6905-6910

Department of Radiation Oncology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea

Background: This study evaluated the efficacy of haematological markers for predicting the pathological complete regression (pCR) during and after neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC).

Patients And Methods: A total of 297 patients with LARC underwent neoadjuvant CRT followed by surgical resection. Complete blood counts (CBCs) were performed before CRT, 3 weeks after the start of CRT (intra-therapy), and 4 weeks after CRT. Read More

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December 2018
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Prognostic Significance of Survivin Expression and Combined Analysis with Cancer Stem Cell and Epithelial-Mesenchymal Transition-related Markers in Patients with Rectal Cancer Undergoing Preoperative Chemoradiotherapy.

Anticancer Res 2018 Dec;38(12):6881-6889

Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Republic of Korea.

Aim: To identify the candidate marker predicting treatment response and survival outcome in rectal cancer patients who received preoperative chemoradiotherapy (CRT).

Patients And Methods: Between 2000 and 2015, 159 patients with histologically-confirmed rectal adenocarcinoma underwent preoperative CRT followed by surgery. Among them, 70 patients were enrolled and the expression of survivin, cancer stem cell markers (CD44 and CD133) and epithelial-mesenchymal transition markers (E-cadherin and TWIST1) in pretreatment biopsy specimens were evaluated by immunohistochemistry. Read More

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December 2018

A Matched-Pair Study Comparing Surgery Plus Neoadjuvant Radio-Chemotherapy and Surgery Alone for High Rectal Cancers.

Anticancer Res 2018 Dec;38(12):6877-6880

Department of Surgery, Zealand University Hospital, Køge, Denmark.

Background/aim: The value of neoadjuvant radiochemotherapy for high rectal cancers is controversial. This study compared surgery plus neoadjuvant radiochemotherapy to surgery alone.

Patients And Methods: Fifty-two patients with stage II/III high rectal cancers treated with surgery plus neoadjuvant radiochemotherapy were matched (1:4) to 208 patients treated with surgery alone. Read More

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December 2018

Chemotherapy in Patients with Hereditary Angioedema.

Anticancer Res 2018 Dec;38(12):6801-6807

Internal Medicine Department, Tor Vergata University Hospital, Medical Oncology Unit, Rome, Italy.

Background: Hereditary angioedema (HAE) is an autosomal dominant hereditary disorder characterized by episodic swelling of many body regions (especially throat and abdomen), potentially triggered by medication. No data are available for HAE in patients with cancer assigned to standard chemotherapy. The aim of our study was to identify circulating mediators potentially predictive of acute HAE attacks during chemotherapy. Read More

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December 2018
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Chylomicron mimicking solid lipid nanoemulsions encapsulated enteric minicapsules targeted to colon for immunization against hepatitis B.

Int Immunopharmacol 2018 Nov 29;66:317-329. Epub 2018 Nov 29.

SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, CG 495009, India. Electronic address:

The oral route is one of the most convenient routes for drug and/or vaccine delivery. Yet variable nature of gastrointestinal tract due to transient changes in pH, physiology, and flora throughout the gut together with hostile nature of peptide drugs/vaccines when given by this route results in limited success. Colon targeting is a recent area of interest for most of the research among which hard gelatin coated capsules is one such important and useful contrivance. Read More

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November 2018
1 Read

Placement of Inflatable Penile Implants in Patients With Prior Radical Pelvic Surgery: A Literature Review.

Sex Med Rev 2018 Nov 29. Epub 2018 Nov 29.

Florida Hospital Tampa Urology, Tampa, FL, USA. Electronic address:

Background: Penile prosthesis for erectile restoration remains the only surgical option for medical refractory erectile dysfunction. Many expert prosthetic surgeons recommend special care when placing a reservoir in a patient who has undergone prior radical pelvic surgery (PRPS) due to distortion of anatomy and obliteration of the dead space in the traditionally used space of Retzius.

Aim: Review all the current literature on penile prosthesis implantation in patients with prior pelvic surgery, with an emphasis on tips and tricks for reservoir placement in this unique population. Read More

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November 2018

Thermoregulation and markers of muscle breakdown in malignant hyperthermia susceptible volunteers during an acute heat tolerance test.

J Sci Med Sport 2018 Nov 23. Epub 2018 Nov 23.

Survival and Thermal Medicine Department, Institute of Naval Medicine, UK.

Objectives: The study was undertaken to compare the thermal and biochemical responses to a heat tolerance test (HTT) of malignant hyperthermia (MH) susceptible individuals, volunteers who have suffered heat illness (HI) and control volunteers.

Methods: Three groups of male volunteers (n=6 in each group) were recruited to the study: MHS - civilian volunteers previously diagnosed as MH susceptible; EHI - military volunteers with a history of exertional HI; CON - military volunteers with no history of HI or MH. For the HTT, volunteers walked on a treadmill at 60% maximal oxygen uptake in a hot environment. Read More

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November 2018
1 Read

Update on Strategies to Reduce Infectious Complications After Prostate Biopsy.

Eur Urol Focus 2018 Nov 29. Epub 2018 Nov 29.

Academic Department of Urology, CHRU Tours, François Rabelais University, Tours, France. Electronic address:

Context: Prostate biopsy is one of the most performed procedures in urology. As a diagnostic procedure it should be of low risk. However, morbidity following prostate biopsy is common due to infectious complications. Read More

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November 2018

Invasion of human deep nodular endometriotic lesions is associated with collective cell migration and nerve development.

Fertil Steril 2018 Dec;110(7):1318-1327

Institut du Sein et de Chirurgie Gynécologique d'Avignon, Polyclinique Urbain V (ELSAN Group), Avignon, France.

Objective: To study the mechanisms of invasion and innervation of deep endometriosis in women.

Design: Morphologic and immunohistochemical analysis of human endometriotic lesions.

Setting: Academic research unit. Read More

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December 2018

Melarsomine hydrochloride (Cymelarsan) fails to cure horses with Trypanosoma equiperdum OVI parasites in their cerebrospinal fluid.

Vet Parasitol 2018 Dec 9;264:47-51. Epub 2018 Nov 9.

ANSES, Dozulé Laboratory for Equine Diseases, Bacteriology Unit, 14430, Goustranville, France.

The aim of this study was to evaluate the ability of melarsomine hydrochloride (Cymelarsan) to cure horses suffering from a nervous form of dourine, a sexually-transmitted disease caused by Trypanosoma equiperdum. The recently described experimental model for assessing drug efficacy against horse trypanosomosis allowed us to obtain eight horses (Welsh pony mares) infected by T. equiperdum with parasites in their cerebrospinal fluid. Read More

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December 2018

Anastomotic leakage after anterior resection in patients with rectal cancer previously irradiated for prostate cancer.

Eur J Surg Oncol 2018 Nov 20. Epub 2018 Nov 20.

Colorectal Unit, Department of Surgery and Centre for Clinical Research of Uppsala University, Västmanland´s Hospital Västerås, Sweden.

Introduction: There are little data on the post-operative outcome of anterior resection (AR) for rectal cancer in men who had received radiotherapy for prostate cancer previously. The aim of this study was to assess the rate of anastomotic leakage (AL) after AR in these patients.

Methods: All men who underwent bowel resection because of rectal cancer between 2000 and 2016 and had been diagnosed previously with prostate cancer were identified by linking the Swedish Colorectal Cancer Registry with the National Prostate Cancer Register. Read More

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November 2018
1 Read

Fecal microbiota transplantation to eradicate vancomycin-resistant enterococci colonization in case of an outbreak.

Med Mal Infect 2018 Nov 27. Epub 2018 Nov 27.

Service de maladies infectieuses et tropicales, hôpital Raymond-Poincaré, AP-HP, 104, boulevard Raymond-Poincaré, 92380 Garches, France.

Objective: A rapid and worrying emergence of vancomycin-resistant enterococci (VRE) gut colonization is occurring worldwide and may be responsible for outbreaks, especially in healthcare facilities. While no efficient decolonization strategies are recommended, we assessed fecal microbiota transplantation (FMT) to eradicate VRE colonization.

Patients And Method: Our main objective was to measure the impact of FMT on decolonization of VRE carriers, confirmed by at least two consecutive negative rectal swabs at one-week interval during a 3-month follow-up period. Read More

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November 2018

Colorectal Cancer Surgery Using the Da Vinci Xi and Si Systems: Comparison of Perioperative Outcomes.

Surg Innov 2018 Dec 3:1553350618816788. Epub 2018 Dec 3.

1 Taipei Medical University, Taiwan.

Purpose: Robotic surgery for colorectal cancer is an emerging technique. Potential benefits as compared with the conventional laparoscopic surgery have been demonstrated. However, experience with the previous da Vinci Si robotic system revealed several unsolved problems. Read More

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December 2018
2 Reads

A Case of Asymptomatic Syphilitic Proctitis.

Sex Transm Dis 2018 Dec 3. Epub 2018 Dec 3.

Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles.

The incidence of syphilis is increasing. Syphilitic proctitis involving the rectal mucosa often presents with pain on defecation, rectal bleeding, or ulceration. We present a case of asymptomatic syphilitic proctitis diagnosed upon a routine screening colonoscopy. Read More

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December 2018
1 Read

The importance of clinical approach in aggravated sexual abuse: Case report.

Ulus Travma Acil Cerrahi Derg 2018 Nov;24(6):597-600

Department of Forensic Medicine, Manisa Celal Bayar University Faculty of Medicine, Manisa-Turkey.

The reported rate of sex crimes, some of the most severe acts of violence that can be perpetrated against an individual, is increasing across all societies, regardless of gender or age of the victim. Sexual abuse has been defined, in part, as the involvement of a child in sexual activity for which they are incapable of giving consent, that they cannot fully comprehend, or for which they are developmentally immature. Molestation of the anorectal region is frequently encountered when the victim of sexual abuse is a male child. Read More

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November 2018
2 Reads

Neurological soft signs and grey matter abnormalities in individuals with ultra-high risk for psychosis.

Psych J 2018 Dec 4. Epub 2018 Dec 4.

Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Neurological soft signs (NSSs), conventionally defined as subtle neurological abnormalities, are frequently found in individuals with schizophrenia. Many neuroimaging studies have also reported that NSSs are associated with grey matter changes in patients with schizophrenia at different stages of the illness. However, these findings may be confounded by the effect of antipsychotic medications, chronicity, and duration of untreated psychosis. Read More

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December 2018
1 Read

Management of Ulcerative Colitis in the Elderly.

Drugs Aging 2018 Dec 4. Epub 2018 Dec 4.

Division of Gastroenterology, University of Arizona College of Medicine, 1501 N Campbell Ave, PO Box: 24502B, Tucson, AZ, 85724, USA.

The incidence rate of ulcerative colitis (UC) in older patients is rising. Diagnosis of UC may be difficult in older patients as several common gastrointestinal disorders can mimic UC in these patients. Compared with younger adults, left-sided colitis is more common in older-onset UC, while rectal bleeding, abdominal pain, and extraintestinal manifestations are less common. Read More

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December 2018

Restrictive Intraoperative Fluid Therapy is Associated with Decreased Morbidity and Length of Stay Following Hyperthermic Intraperitoneal Chemoperfusion.

Ann Surg Oncol 2018 Dec 4. Epub 2018 Dec 4.

Division of Surgical Oncology, Department of Surgery, University of Massachusetts Medical School, Worcester, MA, USA.

Background: Recent data have demonstrated multiple benefits of intra- and postoperative fluid restriction in major abdominal surgery; however, data regarding the outcomes of fluid restriction in cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion (CRS/HIPEC) are limited. This study evaluates the safety and short-term clinical outcomes of restricted intraoperative fluid therapy in CRS/HIPEC.

Methods: This was a single-institution, retrospective review of all CRS/HIPEC procedures performed at the University of Massachusetts Medical School between January 2009 and July 2017. Read More

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December 2018
1 Read

Prognostic subdivision of pT2 rectal carcinomas.

Int J Colorectal Dis 2018 Dec 4. Epub 2018 Dec 4.

Department of Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstr. 12, 91054, Erlangen, Germany.

Purpose: The aim of the present study is to explore the prognostic impact of a subdivision of pT2 by the depth of invasion into the muscularis propria in rectal carcinomas.

Methods: Data from 269 consecutive patients with rectal carcinoma treated with primary tumor resection and lymph node dissection between 1986 and 2012 were analyzed with respect to locoregional and distant recurrence, disease-free survival, and overall survival. The depth of invasion into the muscularis propria of pT2 carcinomas was categorized by the pathologist into two groups: pT2a, invasion into the inner half of the muscularis propria; pT2b, invasion into the outer half of the muscularis propria. Read More

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December 2018

Effect of Commonly Used Pediatric Antibiotics on Gut Microbial Diversity in Preschool Children in Burkina Faso: A Randomized Clinical Trial.

Open Forum Infect Dis 2018 Nov 2;5(11):ofy289. Epub 2018 Nov 2.

Francis I. Proctor Foundation.

Background: Exposure to antibiotics may result in alterations to the composition of intestinal microbiota. However, few trials have been conducted, and observational studies are subject to confounding by indication. We conducted a randomized controlled trial to determine the effect of 3 commonly used pediatric antibiotics on the intestinal microbiome in healthy preschool children. Read More

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November 2018

Factor-XIII activity in patients with mild to moderate ulcerative colitis and active bleeding: a prospective observational study.

BMC Res Notes 2018 Dec 4;11(1):853. Epub 2018 Dec 4.

Practice for Digestive and Metabolic Diseases, Nordstr. 21, 04105, Leipzig, Germany.

Objective: Coagulation factor XIII plays a key role in fibrin clot stabilization and epithelial healing. Under chronic inflammatory conditions involving bleeding and an activation of the coagulation cascade, the FXIIIa inversely correlate with disease activity. We assumed that FXIIIa could be a predictor of severity in patients with ulcerative colitis (UC). Read More

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December 2018
1 Read

Physical activity patterns and the risk of colorectal cancer in the Norwegian Women and Cancer study: a population-based prospective study.

BMC Cancer 2018 Dec 4;18(1):1216. Epub 2018 Dec 4.

Department of Community Medicine, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway.

Introduction: Colorectal cancer (CRC) remains the second most common cancer in women worldwide. Physical activity (PA) has been associated with reduced risk of CRC; however, this has been demonstrated more consistently in men, while results of studies in women have been largely equivocal. We aimed to further examine the relationship between PA patterns and the risk of CRC in women, using repeated measurements. Read More

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December 2018

Prognostic Implications of Extranodal Extension in Relation to Colorectal Cancer Location.

Cancer Res Treat 2018 Nov 29. Epub 2018 Nov 29.

Department of Surgery, Institute of Innovative Cancer Research, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: Extranodal extension (ENE) is closely associated with the aggressiveness of both colon and rectal cancer. This study evaluated the clinicopathologic significance and prognostic impact of ENE in separate populations of patients with colon and rectal cancers.

Materials And Methods: The medical records of 2,346 patients with colorectal cancer (CRC) who underwent curative surgery at our institution between January 2003 and December 2011 were clinically and histologically reviewed. Read More

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November 2018
1 Read

Preoperative endoscopic clipping for rectal tumor localization in laparoscopic anterior resection.

Minim Invasive Ther Allied Technol 2018 Dec 4:1-6. Epub 2018 Dec 4.

a Center for Colorectal Cancer, Research Institute and Hospital , National Cancer Center , Goyang , Korea.

Background: Increasing the number of rectal tumors undergoing preoperative chemoradiotherapy or endoscopic resection has increased the importance of accurate tumor localization. This study describes the preoperative endoscopic clipping method for the localization of rectal tumors and evaluated the feasibility of this technique.

Material And Methods: A total of 109 patients underwent preoperative endoscopic clipping to localize non-palpable rectal adenocarcinomas, which were located within 10 cm from the anal verge. Read More

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December 2018