64,923 results match your criteria Rectal Carcinoma


Tumour budding, poorly differentiated clusters, and T-cell response in colorectal cancer.

EBioMedicine 2020 Jul 8;57:102860. Epub 2020 Jul 8.

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Cancer Immunology and Cancer Epidemiology Programs, Dana-Farber Harvard Cancer Center, Boston, Massachusetts, USA. Electronic address:

Background: Tumour budding and poorly differentiated clusters (PDC) represent forms of tumour invasion. We hypothesised that T-cell densities (reflecting adaptive anti-tumour immunity) might be inversely associated with tumour budding and PDC in colorectal carcinoma.

Methods: Utilising 915 colon and rectal carcinomas in two U. Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102860DOI Listing

Efficacy of preemptive endoscopic submucosal dissection and surgery for synchronous colorectal neoplasms.

Scand J Gastroenterol 2020 Jul 10:1-7. Epub 2020 Jul 10.

Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.

Background And Aim: If patients with surgically resectable colorectal cancershave synchronous colorectal neoplasms that are difficult to remove by endoscopic mucosal resection, preemptive endoscopic submucosal dissection (ESD) can avoid excessive colorectal resection. The aim of this study was to evaluate the efficacy of the strategy of preemptive ESD and surgery for synchronous colorectal neoplasms.

Methods: Patients who underwent preemptive ESD and surgery for synchronous colorectal neoplasms between September 2002 and December 2017 were enrolled in this retrospective cohort study. Read More

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http://dx.doi.org/10.1080/00365521.2020.1792542DOI Listing

Survival and quality of life outcomes of high-intensity focused ultrasound treatment of localized prostate cancer.

Prostate Int 2020 Jun 12;8(2):85-90. Epub 2020 Mar 12.

Department of Urology, Alfred Health, Melbourne, Victoria, Australia.

Background: To evaluate the survival and quality of life (QoL) outcomes of high-intensity focused ultrasound (HIFU) whole-gland ablation for localized prostate cancer.

Methods: Over 8 years, men with localized prostate cancer treated with whole-gland HIFU were prospectively followed. Transrectal prostate ablation was performed under general anesthesia with Sonablate-500® (Sonacare Medical©, Charlotte, North Carolina, USA). Read More

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http://dx.doi.org/10.1016/j.prnil.2019.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335960PMC

Locally Advanced Rectal Cancer, What is the Standard of Care?

Oncology (Williston Park) 2020 Jan;34(1):16-19

Morrison Cancer Center, Mary Lanning Healthcare, Hastings, NE.

Colorectal carcinoma is the second leading cause of cancer-related deaths in the United States, with rectal cancer accounting for approximately one-third of newly diagnosed cases. A comprehensive trimodality approach involving neoadjuvant chemoradiotherapy, total mesorectal excision, and systemic chemotherapy has been the standard of care for medically operable patients with nonmetastatic, locally advanced rectal cancer. Despite a marked reduction in local recurrence rates with good local control, systemic recurrence rates of as high as 35% constitute the leading cause of death in this population. Read More

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January 2020

Colorectal carcinoma presenting in the orbit: mass effect from an uncommon cause.

Orbit 2020 Jul 9:1-4. Epub 2020 Jul 9.

Division of Oculofacial Plastic and Reconstructive Surgery, UC San Diego Viterbi Family Department of Ophthalmology, Shiley Eye Institute , La Jolla, California, USA.

An 84-year-old male with previously documented poor medical follow-up presented with progressive painless proptosis of the right eye. Right upper eyelid ptosis, limited motility, proptosis, and inferomedial displacement of the right globe were noted on the exam. Computed tomography (CT) imaging revealed a right retrobulbar extraconal heterogenous mass with ill-defined borders. Read More

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http://dx.doi.org/10.1080/01676830.2020.1787466DOI Listing

Pathological Predictors of Response to Neoadjuvant Treatment in Rectal Carcinoma.

J Gastrointest Cancer 2020 Jul 9. Epub 2020 Jul 9.

Department of Biostatics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: Neoadjuvant chemoradiotherapy has now become a standard treatment for rectal cancer. Recently, attempts have been made to predict the response rate to this treatment to decide whether or not it must be performed. However, tissue factors for predicting the response rate is not cohesively reviewed. Read More

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http://dx.doi.org/10.1007/s12029-020-00450-8DOI Listing

Molecular Alterations in Circulating Cell-Free DNA in Patients with Colorectal Adenoma or Carcinoma.

Cancer Manag Res 2020 30;12:5159-5167. Epub 2020 Jun 30.

Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, People's Republic of China.

Purpose: The aim of this study was to evaluate the clinical value of plasma cell-free DNA (cfDNA) in the diagnosis of colorectal cancer (CRC).

Patients And Methods: The plasma cfDNA and tissue DNA mutation profiles were investigated in 77 patients (9 colon polyps, 18 colon adenoma, 26 colon cancer, and 24 rectal cancer) by a cancer gene-targeted NGS panel.

Results: During the progression from adenoma to carcinoma, mutations occur in genes such as RAS, Wnt, Hippo, Nrf2, TGFβ, PI3K, Notch, and P53, as well as in those encoding cell cycle pathway components. Read More

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http://dx.doi.org/10.2147/CMAR.S244520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335290PMC

TTF-1, napsin A, and CDX2 Co-expression in Metastatic Rectal Adenocarcinoma to the Lung.

Cytopathology 2020 Jul 7. Epub 2020 Jul 7.

Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

The distinction between metastatic colorectal carcinoma and primary carcinoma of the lung is a frequently encountered diagnostic problem and clinically significant. Immunohistochemistry in conjunction with cytomorphology and clinical history are important to make this distinction. Read More

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http://dx.doi.org/10.1111/cyt.12884DOI Listing

The prognostic impact of neoadjuvant chemoradiotherapy on lymph node sampling in patients with locally advanced rectal cancer.

Updates Surg 2020 Jul 6. Epub 2020 Jul 6.

Department of Medical and Surgical Sciences and Advanced Technology "G.F. Ingrassia", University of Catania, Via Santa Sofia 86, Catania, Sicily, Italy.

According to the American Joint Committee on Cancer, at least 12 lymph nodes are required to accurately stage locally advanced rectal cancer (LARC). Neoadjuvant chemoradiation therapy (NACRT) reduces the number of lymph nodes retrieved during surgery. In this study, we evaluated the effect of NACRT on lymph node retrieval and prognosis in patients with LARC. Read More

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http://dx.doi.org/10.1007/s13304-020-00841-3DOI Listing

Quality of Life After Radiotherapy for Rectal and Anal Cancer.

Curr Colorectal Cancer Rep 2020 Feb 16;16(1):1-10. Epub 2020 Jan 16.

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, United States.

Purpose Of Review: With advances in radiation therapy (RT) techniques for rectal and anal cancers allowing for the modulation of critical normal tissues, there has been an increased emphasis on improving the quality of life (QOL) of cancer survivors. Herein, we review the literature to examine the impact of RT on QOL and patient reported outcomes (PROs) to better inform providers about the challenges of survivorship.

Recent Findings: Large systematic reviews, recent studies and long-term follow-up of pivotal clinical trials have shown that RT impacts QOL, particularly fecal continence and sexual function. Read More

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http://dx.doi.org/10.1007/s11888-019-00448-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336840PMC
February 2020

Clinicopathological study of blue nevi of the gastrointestinal (GI) tract: first case series.

J Clin Pathol 2020 Jul 6. Epub 2020 Jul 6.

Pathology, Johns Hopkins University, Baltimore, Maryland, USA.

Aim: Blue nevus (BN) is a benign melanocytic proliferation that is typically cutaneous. Extracutaneous BN is infrequent and is reported in the mucosa of various organs. Gastrointestinal (GI) tract BN is rare. Read More

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http://dx.doi.org/10.1136/jclinpath-2020-206757DOI Listing

Is a sampling transition zone important to increase the detection of prostate cancer in systematic prostatic biopsies?

Acta Radiol 2020 Jul 6:284185120938363. Epub 2020 Jul 6.

Department of Interventional Radiology, Hospital Israelita Albert Einstein, São Paulo, Brazil.

Background: Use of transrectal ultrasound (US)-guided biopsies improved diagnosis and treatment for patients with high prostate-specific antigen (PSA) or abnormal digital rectal exam (DRE).

Purpose: To investigate whether taking two transition zone (TZ) biopsies in addition to routine prostate double-sextant biopsies (12-cores) would improve detection rates of prostate cancer (PCa).

Material And Methods: A retrospective analysis of 1107 in a single institution database after Institutional Review Board approval, which underwent US-guided prostate biopsies from January 2014 to June 2016. Read More

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http://dx.doi.org/10.1177/0284185120938363DOI Listing

MR Imaging Texture Analysis in the Abdomen and Pelvis.

Magn Reson Imaging Clin N Am 2020 Aug 6;28(3):447-456. Epub 2020 Jun 6.

Department of Radiology, University of Alabama at Birmingham, 619 19th Street South, Birmingham, AL 35249-6830, USA.

Add "which is a" before "distribution"? Texture analysis (TA) is a form of radiomics that refers to quantitative measurements of the histogram, distribution and/or relationship of pixel intensities or gray scales within a region of interest on an image. TA can be applied to MR images of the abdomen and pelvis, with the main strength quantitative analysis of pixel intensities and heterogeneity rather than subjective/qualitative analysis. There are multiple limitations of MRTA. Read More

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http://dx.doi.org/10.1016/j.mric.2020.03.009DOI Listing

The Value of Endoscopy as a Predictive Factor when Evaluating the Clinical Response to Neoadjuvant Chemoradiotherapy for Patients with Rectal Cancer.

Chirurgia (Bucur) 2020 May-Jun;115(3):373-379

Standard treatment rectal cancer according to numerous international guidelines recommends neoadjuvant chemoradiotherapy (nCRT). Literature data suggests that a better response to nCRT (greater tumour regression) leads to improved overall survival rates (OS) and disease-free survival rates (DFS). Tumour response to nCRT can be assessed either through clinical or pathological examination. Read More

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http://dx.doi.org/10.21614/chirurgia.115.3.373DOI Listing

Parameters for Predicting Tumour Response Following Neoadjuvant Chemoradiotherapy for Patients with Rectal Cancer.

Chirurgia (Bucur) 2020 May-Jun;115(3):365-372

Pathologic response following neoadjuvant chemoradiotherapy (nCRT) can vary from pathologic complete response (pCR), to tumour downstaging or minimum to no response. Our goal was to evaluate the parameters that could predict response to neoadjuvant therapy for patients with rectal cancer. Method: We performed a retrospective study and reviewed the medical documentation for patients that received treatment for rectal cancer in our surgical department between 2014-2018 and received nCRT. Read More

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http://dx.doi.org/10.21614/chirurgia.115.3.365DOI Listing

Patient-reported and doctor-reported symptoms when faecal immunochemical tests are requested in primary care in the diagnosis of colorectal cancer and inflammatory bowel disease: a prospective study.

BMC Fam Pract 2020 Jul 1;21(1):129. Epub 2020 Jul 1.

Department of Public Health and Clinical Medicine, Unit of Research, Education and Development - Östersund, Östersund Hospital, Umeå University, Umeå, Sweden.

Background: Rectal bleeding and a change in bowel habits are considered to be alarm symptoms for colorectal cancer and they are also common symptoms for inflammatory bowel disease. However, most patients with these symptoms do not have any of these diseases. Faecal immunochemical tests (FITs) for haemoglobin are used as triage tests in Sweden and other countries but little is known about the symptoms patients have when FITs are requested. Read More

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http://dx.doi.org/10.1186/s12875-020-01194-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331274PMC

Cotargeting CHK1 and PI3K Synergistically Suppresses Tumor Growth of Oral Cavity Squamous Cell Carcinoma in Patient-Derived Xenografts.

Cancers (Basel) 2020 Jun 29;12(7). Epub 2020 Jun 29.

Department of Otolaryngology Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.

Oral cavity squamous cell carcinomas (OSCCs) are aggressive tumors, and their recurrence leads to poor prognosis and reduced survival rates. This study aimed to identify therapeutic targets and to evaluate the efficacy of targeted inhibitors in OSCC patient-derived xenograft (PDX) models. Herein, we reported that OSCC PDXs recapitulated the genomic signatures of their paired primary tumors and the expression of , , and was significantly upregulated in OSCC. Read More

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http://dx.doi.org/10.3390/cancers12071726DOI Listing

Prognostic Impact of the Neoadjuvant Rectal Score as Compared With the Tumor Regression Grade and Yield Pathologic TNM Stage in Patients With Locally Advanced Rectal Cancer After Neoadjuvant Chemoradiotherapy.

In Vivo 2020 Jul-Aug;34(4):1993-1999

Department of Oncology/Hematology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Kyungpook National University Cancer Research Institute, Daegu, Republic of Korea

Background/aim: The present study compared the prognostic value of the yield pathologic (yp) stage, tumor regression grade (TRG), and neoadjuvant rectal (NAR) score in patients with locally advanced rectal cancer (LARC) who received neoadjuvant chemoradiotherapy (nCRT).

Patients And Methods: For the assessment of tumor regression, the Dworak grading system was used. The NAR score was calculated using the following equation: (5ypN-3[cT-ypT]+12)÷9. Read More

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http://dx.doi.org/10.21873/invivo.11997DOI Listing

A rectal metastasis of an unknown lobular breast carcinoma and its management.

Acta Gastroenterol Belg 2020 Apr-Jun;83(2):327-330

Clinique Saint Jean, Bruxelles, Belgium.

Breast cancer is the most common cancer in women but gastro- intestinal metastases of breast cancer are rare. They can occur years after the diagnosis or at the diagnosis of breast cancer. We report the case of a patient complaining of dyschesia, tenesmus and anal incontinence leading to the discovery of a rectal metastasis of an unknown breast neoplasia. Read More

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Qualitative faecal immunochemical tests (FITs) for diagnosing colorectal cancer in patients with histories of rectal bleeding in primary care: a cohort study.

Int J Colorectal Dis 2020 Jun 29. Epub 2020 Jun 29.

School of Medical Sciences, University Health Care Research Centre, Örebro University, Örebro, Sweden.

Background: Rectal bleeding is considered an alarm symptom for colorectal cancer (CRC) but it is common and mostly caused by benign conditions. Qualitative faecal immunochemical tests (FITs) for occult blood have been used as diagnostic aids for many years in Sweden when CRC is suspected. The study aimed to evaluate the usefulness of FITs requested by primary care physicians for patients with and without histories of rectal bleeding, in the diagnosis of CRC. Read More

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http://dx.doi.org/10.1007/s00384-020-03672-1DOI Listing

Primary signet ring cell carcinoma with tubular adenoma of the rectum: A case report and a review of the literature.

Medicine (Baltimore) 2020 Jun;99(26):e20985

Department of General Surgery, The Second Hospital of Jilin University.

Rationale: Among the various forms of colorectal carcinomas, primary signet ring cell carcinoma (SRCC) of rectum is infrequent. Primary SRCC with adenoma is even rarer. Due to its low morbidity and lack of obvious manifestations at early stages, it is difficult to make an early diagnosis and perform surgical intervention in time. Read More

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http://dx.doi.org/10.1097/MD.0000000000020985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328922PMC

The Role of the Intestinal Microbiome on Colorectal Cancer Pathogenesis and its Recurrence Following Surgery.

J Gastrointest Surg 2020 Jun 25. Epub 2020 Jun 25.

Division of Colon and Rectal Surgery, University of Chicago, Room J557F, MC 5095, 5841 S. Maryland Ave, Chicago, IL, 60637, USA.

Colorectal cancer is the result of multiple genetic mutations that drive normal cells to adenoma and then carcinoma. Recent technology has evolved to allow for an in-depth examination of the microbiota and it has become clear that many components of the intestinal microbiome play a role in promoting carcinogenesis. This review aims to describe the potential mechanisms that lead to the dysbiosis that initiates tumor formation and that influence the development of cancer recurrence following surgical resection. Read More

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http://dx.doi.org/10.1007/s11605-020-04694-4DOI Listing

The presence of poorly differentiated clusters predicts survival in stage II colorectal cancer.

Virchows Arch 2020 Jun 23. Epub 2020 Jun 23.

Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.

In stage II colorectal carcinoma (CRC), adjuvant chemotherapy is reserved to cases at high risk of adverse outcome. This study aims to investigate the prognostic value of tumor budding (TB) and poorly differentiated clusters (PDC) in this setting. In a cohort of 149 patients with surgically resected stage II CRC not undergoing neoadjuvant or adjuvant treatments, we assessed the prognostic value of several clinical-pathological variables, including PDC and TB, on cancer-specific survival (CSS). Read More

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http://dx.doi.org/10.1007/s00428-020-02880-yDOI Listing

[The safety and efficacy of radical surgery after modified total neoadjuvant therapy for locally advanced rectal cancer].

Zhonghua Zhong Liu Za Zhi 2020 Jun;42(6):501-506

Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To analyze the clinical-pathological data of patients with locally advanced rectal cancer who underwent modified total neoadjuvant therapy (TNT), and to evaluate the safety and efficacy of radical surgery after modified total neoadjuvant therapy. The clinical-pathological data of 30 locally advanced rectal cancer patients who underwent modified TNT (mTNT) followed by radical resection were retrospectively analyzed. The surgical procedure, postoperative complications, tumor regression grade, tumor downstaging and prognosis were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112152-20191128-00767DOI Listing

[Progress in diagnosis and treatment of rectal neuroendocrine neoplasms].

Zhonghua Zhong Liu Za Zhi 2020 Jun;42(6):438-444

Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Neuroendocrine neoplasms (NENs) are relatively rare heterogeneous tumors that originate from peptidergic neurons and neuroendocrine cells and have been referred to as "carcinoids" in the past. Although this type of tumor had been previously considered to be indolent tumor with a low degree of malignancy, with the development of medicine and clinical study, researchers found that NENs had the potential to metastasize. They can occur in any part of the body where neuroendocrine cells are distributed and gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) are the most common type of NENs. Read More

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http://dx.doi.org/10.3760/cma.j.cn112152-20190820-00539DOI Listing

Endoscopic surveillance after surgery for colorectal cancer.

Minerva Med 2020 Jun 22. Epub 2020 Jun 22.

Gastroenteorlogy Unit, Department of Medical and Surgical Sciences, S.Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy -

Colorectal cancer (CRC) is one of the most common cancers worldwide and its global incidence is rapidly increasing among adults younger than 50 years, especially in the 20-39 age group. Once a curative resection is achieved, surveillance is mandatory. Colonoscopy has a pivotal role aimed at resecting pre-malignant neoplasms and detecting cancer at a curable stage. Read More

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http://dx.doi.org/10.23736/S0026-4806.20.06732-4DOI Listing

Locoregional staging using magnetic resonance imaging in rectal cancer: influence of diffusion-weighted imaging in the diagnostic accuracy.

Cir Cir 2020 ;88(4):420-427

Departamento de Ciencias Clínicas, Facultad de Medicina, Universidad de Las Palmas de Gran Canaria. Las Palmas de Gran Canaria, España.

Objective: To assess whether the accuracy in locoregional staging using magnetic resonance imaging (MRI) in rectal cancer (primary or post-chemoradiotherapy) improves by adding diffusion-weighted imaging, according to the radiologist's degree of experience.

Method: Retrospective study on 100 MRI records (1.5 T, 2011-2016) from patients with rectal cancer (reference standard: histology of surgical specimens). Read More

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http://dx.doi.org/10.24875/CIRU.20001719DOI Listing
January 2020

[Two cases of rectal neuroendocrine carcinoma associated with long-standing ulcerative colitis].

Nihon Shokakibyo Gakkai Zasshi 2020 ;117(6):521-531

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University.

Two cases of neuroendocrine carcinoma, complicated with ulcerative colitis, were examined. Case 1:The patient developed ulcerative colitis at the age of 38, surgery was performed after a diagnosis of rectal cancer at the age of 53, and the patient was diagnosed with neuroendocrine carcinoma by pathological examination after resection. Post-surgery, metastatic nodules were detected in the liver and lungs. Read More

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http://dx.doi.org/10.11405/nisshoshi.117.521DOI Listing
January 2020

Does prehabilitation modify muscle mass in patients with rectal cancer undergoing neoadjuvant therapy? A subanalysis from the REx randomised controlled trial.

Tech Coloproctol 2020 Jun 20. Epub 2020 Jun 20.

Institute of Sport, Physical Education and Health Sciences, Moray House School of Education, Edinburgh, UK.

Background: Patients with rectal cancer who present with sarcopenia (low muscle mass) are at significantly greater risk of postoperative complications and reduction in disease-free survival. We performed a subanalysis of a randomised controlled study [the REx trial; www.isrctn. Read More

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http://dx.doi.org/10.1007/s10151-020-02262-1DOI Listing

Diagnostic accuracy of FDG-PET/MRI versus pelvic MRI and thoracic and abdominal CT for detecting synchronous distant metastases in rectal cancer patients.

Eur J Nucl Med Mol Imaging 2020 Jun 20. Epub 2020 Jun 20.

Nuclear Medicine Division, Department of Radiology and Oncology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Rua Doutor Ovidio Pires de Campos, 872, Sao Paulo, SP, 05403-010, Brazil.

Purpose: We compared the diagnostic accuracy of detecting distant metastases for baseline rectal cancer staging between PET/MRI and conventional staging (CS).

Materials And Methods: This prospective study from November 2016 to April 2018 included 101 rectal adenocarcinoma patients for primary staging. These patients underwent whole-body PET/MRI in addition to CS (pelvic MRI and thoracic and abdominal contrast-enhanced CT). Read More

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http://dx.doi.org/10.1007/s00259-020-04911-xDOI Listing

Trends in Colectomies for Colorectal Neoplasms in Ulcerative Colitis: a National Inpatient Sample Database Analysis over Two Decades.

J Gastrointest Surg 2020 Jun 15. Epub 2020 Jun 15.

Faculty of Medicine, McGill University, Montreal, Quebec, Canada.

Background: Rates of colectomy for ulcerative colitis have been decreasing, particularly since the advent of biologics, but the subsequent impact of reduced colectomy rates on the development of neoplasms in chronically treated ulcerative colitis colons is unknown.

Purpose: To determine trends in colectomy for colorectal neoplasms in adult patients with ulcerative colitis.

Methods: Adult admissions with ulcerative colitis were identified from the National Inpatient Sample from 1993 to 2015. Read More

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http://dx.doi.org/10.1007/s11605-020-04666-8DOI Listing

Lower bile duct metastasis from rectal cancer after surgery for liver metastasis and intrahepatic bile duct metastasis: a case report.

BMC Surg 2020 Jun 17;20(1):137. Epub 2020 Jun 17.

Department of Surgery, Ogaki Municipal Hospital, 4-86, Minaminokawa-cho, Ogaki City, Gifu Pref, 503-8502, Japan.

Background: Biliary metastasis of colorectal cancer is a manifestation of metastatic liver carcinoma, and is often difficult to differentiate from cholangiocarcinoma. Further, lower bile duct metastasis of colorectal cancer is rare. We report the case of a 74-year-old woman who underwent pylorus-preserving pancreatoduodenectomy for lower bile duct metastasis of rectal cancer. Read More

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http://dx.doi.org/10.1186/s12893-020-00799-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302383PMC

Validation of the Low Anterior Resection Syndrome Score in Finnish Patients: Preliminary Results on Quality of Life in Different Lars Severity Groups.

Scand J Surg 2020 Jun 18:1457496920930142. Epub 2020 Jun 18.

Department of Digestive Surgery, Turku University Hospital, Turku, Finland and University of Turku, Turku, Finland.

Background And Aims: Low anterior resection syndrome is common after anterior resection for rectal cancer. Its severity can be tested with the low anterior resection syndrome score. We have translated the low anterior resection syndrome score to Finnish, and the aim of this study is to validate the translation. Read More

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http://dx.doi.org/10.1177/1457496920930142DOI Listing

Selective lateral lymph node dissection after neoadjuvant chemoradiotherapy in rectal cancer.

World J Gastroenterol 2020 Jun;26(21):2877-2888

Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union College, Beijing 100021, China.

Background: Lateral lymph node metastasis is one of the leading causes of local recurrence in patients with advanced mid or low rectal cancer. Neoadjuvant chemoradiotherapy (NCRT) can effectively reduce the postoperative recurrence rate; thus, NCRT with total mesorectal excision (TME) is the most widely accepted standard of care for rectal cancer. The addition of lateral lymph node dissection (LLND) after NCRT remains a controversial topic. Read More

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http://dx.doi.org/10.3748/wjg.v26.i21.2877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284184PMC

[Prerequisites of magnetic resonance imaging for treatment planning in locally advanced rectal cancer - Interdisciplinary recommendations].

Z Gastroenterol 2020 Jun 16;58(6):577-582. Epub 2020 Jun 16.

Interdisziplinäres Tumorzentrum, Universitätsmedizin Mannheim.

For the purpose of indication and patient stratification of perioperative treatment of locally advanced rectal cancer, magnetic resonance imaging (MRI) has become indispensable. In this report, we describe the importance of MRI diagnostics and the qualitative conditions. Read More

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http://dx.doi.org/10.1055/a-1085-6874DOI Listing

EMR/ESD: Techniques, Complications, and Evidence.

Curr Gastroenterol Rep 2020 Jun 15;22(8):39. Epub 2020 Jun 15.

Baylor St Luke's Medical Center, Houston, TX, USA.

Purpose Of Review: To discuss endoscopic resection techniques of early gastrointestinal malignancy. The review will focus on the indications and outcomes of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD).

Recent Findings: EMR is indicated for upper GI lesions less than 20 mm provided they can be easily lifted and have a low risk of submucosal invasion (SMI). Read More

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http://dx.doi.org/10.1007/s11894-020-00777-zDOI Listing

Evaluation of genitourinary fistulas in pelvic malignancies with etiopathologic correlation: role of cross sectional imaging in detection and management.

Br J Radiol 2020 Jul 15;93(1111):20200049. Epub 2020 Jun 15.

Department of Surgical Oncology, Basavatarakam Indo American Cancer Hospital & Research Institute, Road No 10, Banjara Hills, Hyderabad, Telangana, India, 500034.

Objective: Genitourinary fistulas in pelvic malignancies are abnormal communications occurring due to either locally advanced tumours invading the surrounding organs or post-therapeutic complications of malignancies. In this article we review and describe the role of cross-sectional imaging findings in the management of genitourinary fistulas in pelvic malignancies.

Methods: A retrospective study, for the period January 2012 to December 2018, was undertaken in patients with pelvic malignancies having genitourinary fistulas. Read More

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http://dx.doi.org/10.1259/bjr.20200049DOI Listing

Should the rectal defect be sutured following TEMS/TAMIS carried out for neoplastic rectal lesions? A Meta-Analysis.

Ann R Coll Surg Engl 2020 Jun 15:1-7. Epub 2020 Jun 15.

Castle Hill Hospital, Hull University Teaching Hospitals, East Yorkshire, UK.

Introduction: Management of the rectal defect following transanal endoscopic microsurgery (TEMS) or minimally invasive surgery (TAMIS) carried out for excision of neoplasm in the lower rectum is controversial. We aimed to extract evidence by carrying out a meta-analysis to compare the peri- and postoperative outcomes following rectal neoplasm excision carried out by TEMS and/or TAMIS, whereby the defect is either sutured or left open.

Methods: A literature search of Ovid MEDLINE and EMBASE was performed. Read More

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http://dx.doi.org/10.1308/rcsann.2020.0135DOI Listing

NICE guideline for rectal cancer: already out of date.

Lancet 2020 06;395(10240):e105-e106

Colorectal Surgical Department, Watford General Hospital, Watford, UK.

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http://dx.doi.org/10.1016/S0140-6736(20)30855-2DOI Listing

Leukocyte immunoglobulin-like receptor subfamily B member 1 potentially acts as a diagnostic and prognostic target in certain subtypes of adenocarcinoma.

Med Hypotheses 2020 May 22;144:109863. Epub 2020 May 22.

Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an 710021, China. Electronic address:

Background: Leukocyte immunoglobulin (Ig)-like receptor subfamily B member 1 (LILRB1) involves in the occurrence and development of various tumors through transmitting immune inhibitory signals. However, the regulatory mechanism of LILRB1 underlying the disease progression of adenocarcinoma remains vague. This study is aimed to disclose the expression pattern of LILRB1 on adenocarcinoma and its indicative roles on the diagnosis and prognosis of adenocarcinoma patients. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109863DOI Listing
May 2020
1.152 Impact Factor

Long-term Outcomes of Primary Endoscopic Resection vs Surgery for T1 Colorectal Cancer: A Systematic Review and Meta-analysis.

Clin Gastroenterol Hepatol 2020 Jun 8. Epub 2020 Jun 8.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, E-DA Hospital/I-shou University, Kaohsiung, Taiwan; School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan. Electronic address:

Background & Aims: There is controversy over the best therapeutic approach for T1 colorectal cancer. We performed a systematic review and meta-analysis of long-term outcomes of endoscopic resection (ER) vs those of primary or additional surgery.

Methods: We performed a systematic review of the PubMed, Embase, and Cochrane databases through October 2019 for studies that reported outcomes (overall survival, disease-specific survival, recurrence-free survival at 5 years, recurrence, and metastasis) of ER vs surgery in patients with colorectal neoplasms. Read More

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http://dx.doi.org/10.1016/j.cgh.2020.05.060DOI Listing
June 2020
7.896 Impact Factor

Comparative Analysis of Amide Proton Transfer MRI and Diffusion-Weighted Imaging in Assessing p53 and Ki-67 Expression of Rectal Adenocarcinoma.

J Magn Reson Imaging 2020 Jun 10. Epub 2020 Jun 10.

Department of Radiology, The Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.

Background: The evaluation of prognostic factors in rectal carcinoma patients has important clinical significance. P53 status and the Ki-67 index have served as prognostic factors in rectal carcinoma. Amide proton transfer (APT) imaging has shown great potential in tumor diagnosis. Read More

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http://dx.doi.org/10.1002/jmri.27212DOI Listing

[Initial report of laparoscopic single incision plus one port with simultaneous robotic-assisted transanal total mesorectal excision for low rectal cancer surgery].

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Jun;23(6):605-609

Department of General of Surgery, Daping Hosiptal, Army Medical University, Chongqing 400042, China.

Robotic-assisted transanal total mesorectal excision (R-TaTME) has unique advantage in low rectal cancer. Single incision plus oneport (SIPOP) laparoscopic operation can synchronously cooperate with robotic-assisted transanal operation, in order to the difficulty of operation, improve the quality of operation and shorten the time of operation. A retrospective analysis was conducted on the clinical and pathological data of one patient who underwent SIPOP synchronously combined with R-TaTME + sigmoid-anal anastomosis + ileostomy at the Department of General Surgery, Army Characteristic Medical Center on September 11, 2019. Read More

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http://dx.doi.org/10.3760/cma.j.cn.441530-20190508-00203DOI Listing

[Application of intestinal stent in prevention of anastomotic leakage after rectal cancer operation].

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Jun;23(6):602-605

Department of General Surgery, Tungwah Hospital, Sun Yet-sen University, Dongguan, Guangdong 523110, China.

To observe preventive effect of intestinal stent against anastomotic leakage after rectal cancer operation. A retrospective cohort study was carried out. Clinical data of 107 patients with low rectal cancer undergoing laparoscopic radical resection from January 2015 to August 2019 were retrospectively analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.cn.441530-20200228-00094DOI Listing

[Innovation, development and improvement of transanal endoscopic instruments].

Authors:
L Kang

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Jun;23(6):600-602

Department of Colorectal Surgery, the Sixth Affiliated Hospital, Sun Yat-sen University, Institute of Gastroenterology, Sun Yat-sen University, Guangzhou, Guangdong 510655, China.

According to the main features of transanal total mesorectal excision (taTME), we have designed a series of patented operating techniques, such as anal retractor, anal speculum and transanal port, to reduce the difficulty of transanal operation, shorten the surgeon's learning curve, and expand the indications of transanal surgery. Read More

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http://dx.doi.org/10.3760/cma.j.cn.441530-20200603-00333DOI Listing

[Surgical key points of precision functional sphincter-preserving surgery].

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Jun;23(6):597-600

Department of Gastrointestinal Surgery, Colorectal Cancer Center, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China.

The principle of sphincter-preserving surgery is to preserve the anal sphincter function under the premise of radical resection. Due to low position of rectal tumor, conventional laparoscopic surgery has difficulties in operating in the deep and narrow pelvis, which may lead to inaccurate tissue dissociation, imprecise positioning of tumor edge, excessive stretch of the anal sphincter complex, and excessive removal of distal rectal mucosa. Moreover, pain from abdominal auxiliary incision has an unavoidable side effect for postoperative recovery. Read More

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http://dx.doi.org/10.3760/cma.j.cn.441530-20200403-00182DOI Listing

[Application of convolutional neural network to risk evaluation of positive circumferential resection margin of rectal cancer by magnetic resonance imaging].

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Jun;23(6):572-577

Department of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China.

To explore the feasibility of using faster regional convolutional neural network (Faster R-CNN) to evaluate the status of circumferential resection margin (CRM) of rectal cancer in the magnetic resonance imaging (MRI). This study was registered in the Chinese Clinical Trial Registry (ChiCTR-1800017410). Case inclusion criteria: (1) the positive area of CRM was located between the plane of the levator ani, anal canal and peritoneal reflection; (2) rectal malignancy was confirmed by electronic colonoscopy and histopathological examination; (3) positive CRM was confirmed by postoperative pathology or preoperative high-resolution MRI. Read More

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http://dx.doi.org/10.3760/cma.j.cn.441530-20191023-00460DOI Listing

[Technological innovation and patent transformation in rectal cancer surgery].

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Jun;23(6):550-556

Department of Gastrointestinal Surgery, Shenzhen People's Hospital, Shenzhen, Guangdong 518020, China.

Surgery for rectal cancer has obtained quick improvement in techniques and concepts in recent years but still has challenging areas. Colorectal surgeons always seek to make operations clearer and easier, so that surgery can be safer and less time-consuming while guaranteeing surgical goals. With this purpose, our team have explored to make innovations in operations for rectal cancer and translate relevant patents from 2009. Read More

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http://dx.doi.org/10.3760/cma.j.cn.441530-20200318-00151DOI Listing

An unexpected death after low anterior resection due to disseminated intravascular coagulation: A case report.

Int J Surg Case Rep 2020 29;71:367-370. Epub 2020 May 29.

Department of Abdominal Surgery, UMC Ljubljana, Zaloška Cesta 7, 1000, Ljubljana, Europe, Slovenia. Electronic address:

Introduction: Disseminated intravascular coagulation (DIC) is a blood clotting disorder that is characterized by intravascular thrombi formation and exhaustion of platelets and coagulation factors resulting in diffuse hemorrhage and multiple organ dysfunction.

Presentation Of Case: We present a case report of a previously healthy middle-aged patient who was treated by low anterior resection for rectal carcinoma and suddenly went into unexpected circulatory shock on the 7th postoperative day. Despite our resuscitation efforts, he succumbed to the disease. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283093PMC

Serrated adenomas with a BRAF mutation in a young patient with familial adenomatous polyposis.

Int J Colorectal Dis 2020 Jun 5. Epub 2020 Jun 5.

Division of Gastroenterology and Hematology/Oncology Department of Medicine, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.

Introduction: Familial adenomatous polyposis (FAP) is typically characterized by more than hundred adenomatous polyps in the colorectum, caused by germline APC mutation. A small proportion of the polyps progress to colorectal adenocarcinoma via adenoma-carcinoma sequence. Serrated lesions and polyps, characterized by a serrated architecture of the epithelium, are noted for two types of genetic pathways in colorectal carcinogenesis. Read More

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http://dx.doi.org/10.1007/s00384-020-03657-0DOI Listing