61,435 results match your criteria Rectal Carcinoma


Anticancer and antimetastatic potential of enterolactone: clinical, preclinical and mechanistic perspectives.

Eur J Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Pharmaceutical Sciences, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra 411038, India.

Currently cancer is the second leading cause of death globally and worldwide incidence and mortality rates of all cancers of males and females are rising tremendously. In spite of advances in chemotherapy and radiation, metastasis and recurrence are considered as the major causes of cancer related deaths. Hence there is a mounting need to develop new therapeutic modalities to treat metastasis and recurrence in cancers. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.02.022DOI Listing
February 2019

Postanal minimally invasive surgery "PAMIS" assisted extra-levator abdominoperineal excision "ELAPE" for cancer: A novel approach in supine position.

Authors:
Ahmed Farag

Arab J Gastroenterol 2019 Feb 12. Epub 2019 Feb 12.

Faculty of Medicine, Cairo University, Egypt. Electronic address:

Local recurrences are more common after abdominoperineal excision (APE) than after anterior resection of rectal cancer. Extralevator APE was introduced to address this problem. The post anal minimally invasive approach had been used by other authors for transperineal mesh rectopexy but not in cancer management. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.02.001DOI Listing
February 2019

[Assessment of individualized treatment of rectal carcinoma].

Chirurg 2019 Feb 14. Epub 2019 Feb 14.

Chirurgische Klinik, Campus Virchow-Klinikum und Mitte, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

Individualized and tailored treatment plays a crucial role in the rating of special operation techniques or certain treatment strategies following defined quality criteria and indicators. Deviations from clearly defined recommendations in guidelines must therefore be justified, documented and evaluated as precisely as possible. The aim of this leading article is to examine the individualized treatment of rectal cancer based on existing evidence and to discuss its role in the light of routinely used treatment algorithms. Read More

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http://dx.doi.org/10.1007/s00104-019-0807-6DOI Listing
February 2019

[Curative Transanal Resection after Neoadjuvant Chemotherapy for Lower Rectal Cancer-A Case Report].

Gan To Kagaku Ryoho 2019 Jan;46(1):130-132

Dept. of Coloproctology, Aizu Medical Center, Fukushima Medical University.

A 53-year-old woman was referred to our hospital with melena. Examinations revealed advanced rectal cancer involving the anal canal with invasion of the left-sided levator ani muscle. Neoadjuvant chemotherapy was administered to preserve anal function. Read More

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January 2019

Right versus left sided metastatic colorectal cancer: Teasing out clinicopathologic drivers of disparity in survival.

Asia Pac J Clin Oncol 2019 Feb 13. Epub 2019 Feb 13.

Footscray Hospital, Western Health, Footscray, Victoria, Australia.

Background: Metastatic colorectal cancer (mCRC) patients with a right-sided primary (RC) have an inferior survival to mCRC arising from a left-sided primary (LC). Previous analyses have suggested multiple factors contribute.

Methods: The Treatment of Recurrent and Advanced Colorectal Cancer (TRACC) Registry prospectively captured data on consecutive mCRC patients. Read More

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http://dx.doi.org/10.1111/ajco.13135DOI Listing
February 2019
1.058 Impact Factor

Development of a Potential Gallium-68-Labelled Radiotracer Based on DOTA-Curcumin for Colon-Rectal Carcinoma: From Synthesis to In Vivo Studies.

Molecules 2019 Feb 12;24(3). Epub 2019 Feb 12.

Radiopharmaceutical Chemistry Unit, Oncologic and High Technologies Department, Azienda USL-IRCCS, via Amendola 2, 42122 Reggio Emilia, Italy.

Colorectal cancer is the third most commonly occurring cancer in men and the second most commonly occurring cancer in women worldwide. We have recently reported that curcuminoid complexes labelled with gallium-68 have demonstrated preferential uptake in HT29 colorectal cancer and K562 lymphoma cell lines compared to normal human lymphocytes. In the present study, we report a new gallium-68-labelled curcumin derivative (Ga-DOTA-C21) and its initial validation as marker for early detection of colorectal cancer. Read More

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http://dx.doi.org/10.3390/molecules24030644DOI Listing
February 2019
2.416 Impact Factor

Response evaluation after neoadjuvant treatment for rectal cancer using modern MR imaging: a pictorial review.

Insights Imaging 2019 Feb 13;10(1):15. Epub 2019 Feb 13.

Department of Radiology, Antoni van Leeuwenhoek - Netherlands Cancer Institute, Amsterdam, The Netherlands.

In recent years, neoadjuvant chemoradiotherapy (CRT) has become the standard of care for patients with locally advanced rectal cancer. Until recently, patients routinely proceeded to surgical resection after CRT, regardless of the response. Nowadays, treatment is tailored depending on the response to chemoradiotherapy. Read More

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http://dx.doi.org/10.1186/s13244-019-0706-xDOI Listing
February 2019

Oncologic evaluation of obesity as a factor in patients with rectal cancer undergoing laparoscopic surgery: a propensity-matched analysis using body mass index.

Ann Surg Treat Res 2019 Feb 30;96(2):86-94. Epub 2018 Jan 30.

Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Purpose: This study evaluated the oncologic impact of obesity, as determined by body mass index (BMI), in patients who underwent laparoscopic surgery for rectal cancer.

Methods: The records of 483 patients with stage I-III rectal cancer who underwent laparoscopic surgery between June 2003 and December 2011 were reviewed. A matching model based on BMI was constructed to balance obese and nonobese patients. Read More

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http://dx.doi.org/10.4174/astr.2019.96.2.86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358594PMC
February 2019
1 Read

Application of magnetic resonance diffusion kurtosis imaging for distinguishing histopathologic subtypes and grades of rectal carcinoma.

Cancer Imaging 2019 Feb 11;19(1). Epub 2019 Feb 11.

Department of Radiology, Sun Yat-sen University First Affiliated Hospital, No. 58, Zhongshan Second Road, Yuexiu District, Guangzhou, 510080, China.

Background: To evaluate the diagnostic performance of diffusion kurtosis imaging (DKI) for distinguishing different histopathological subtypes and grades of rectal carcinoma and to compare DKI with conventional diffusion-weighted imaging (DWI).

Methods: This prospective study involved 132 patients with rectal carcinoma, comprising 116 with adenocarcinoma not otherwise specified (AC) and 16 with mucinous carcinoma (MC). High spatial resolution magnetic resonance (MR) and DKI sequences (b values of 0, 600, 1000, 1500 and 2000 s/mm) were performed for pretreatment evaluation. Read More

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http://dx.doi.org/10.1186/s40644-019-0192-xDOI Listing
February 2019
1 Read

Role of Magnification Chromoendoscopy in the Management of Colorectal Neoplastic Lesions Suspicious for Submucosal Invasion.

Dis Colon Rectum 2019 Feb 5. Epub 2019 Feb 5.

Background: Correctly predicting the depth of tumor invasion in the colorectal wall is crucial for successful endoscopic resection of superficial colorectal neoplasms.

Objective: The aim of this study was to assess the accuracy of magnifying chromoendoscopy in a Western medical center to predict the depth of invasion by the pit pattern classification in patients with colorectal neoplasms with a high risk of submucosal invasion.

Design: This single-center retrospective study, from a prospectively collected database, was conducted between April 2009 and June 2015. Read More

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http://dx.doi.org/10.1097/DCR.0000000000001343DOI Listing
February 2019
2 Reads

[Low Anterior Resection Syndrome - Diagnosis - Therapy - Prophylaxis].

Zentralbl Chir 2019 Feb 5. Epub 2019 Feb 5.

MVZ Portal 10, Münster, Deutschland.

Background: As 5-year survival after rectal cancer surgery has reached 80%, there is increasing interest in quality of life. Low anterior resection syndrome (LARS) is an overall measure of the postoperative functional disorder due to the surgical resection.

Material And Methods: A thorough review of the literature was undertaken to help to define LARS and develop an understanding of its pathophysiology, diagnosis, therapy, and prophylaxis. Read More

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http://dx.doi.org/10.1055/a-0754-2482DOI Listing
February 2019
2 Reads

The value of diffusion kurtosis imaging in assessing mismatch repair gene expression of rectal carcinoma: Preliminary findings.

PLoS One 2019 4;14(2):e0211461. Epub 2019 Feb 4.

Department of Radiology, Yidu Central Hospital, Weifang Medical University, Qingzhou city, Shandong province, People's Repubulic of China.

Purpose: To determine the correlation between the parameters of MR diffusion kurtosis imaging (MR-DKI) and mismatch repair gene expression (MMR) for rectal carcinomas.

Materials And Methods: Data from 80 patients with rectal carcinoma were analyzed in this prospective study. High-resolution T2WI and DKI (b = 0, 800 and 1600 s/mm2, respectively) were performed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211461PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361592PMC
February 2019

[High definition MRI rectal lymph node aided diagnostic system based on deep neural network].

Zhonghua Wai Ke Za Zhi 2019 Feb;57(2):108-113

Department of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University, Qingdao 266000, China.

To investigate the clinical significance of high definition (HD) MRI rectal lymph node aided diagnostic system based on deep neural network. The research selected 301 patients with rectal cancer who underwent pelvic HD MRI and reported pelvic lymph node metastasis from July 2016 to December 2017 in Affiliated Hospital of Qingdao University. According to the chronological order, the first 201 cases were used as learning group. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2019.02.007DOI Listing
February 2019
1 Read

Cutaneous Verrucous Carcinoma Superimposed on Chronically Inflamed Ileostomy Site Skin: A Case Report.

Iran J Pathol 2018 17;13(2):285-288. Epub 2018 Jul 17.

Dept. of Surgery, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.

Verrucous carcinoma (VC) is a rare variant of well differentiated squamous cell carcinoma (SCC) which is usually found in oral cavity mucosa. Cutaneous verrucous carcinoma is a rare entity and in this paper we report a 43 years old man with VCsuperimposed on chronically inflamed skin of ileostomy site. Previously, he was operated to treat rectal adenocarcinoma and has had ileostomy for six months. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339498PMC
July 2018
1 Read

A dosimetric comparison between applicators used for brachytherapy in carcinoma cervix - A single-institute prospective study.

Indian J Cancer 2018 Jul-Sep;55(3):230-232

Department of Radiation Oncology, Basavatarakam Indo American Hospital and Research Institute, Hyderabad, Telangana, India.

Introduction: Cervical cancer is the second most common cancer among Indian women. Radical radiotherapy with external beam radiation therapy (EBRT) and brachytherapy is the standard treatment for FIGO stage IB2 to IVA. An appropriate selection of brachytherapy applicator is needed according to the patient's anatomy. Read More

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http://dx.doi.org/10.4103/ijc.IJC_659_17DOI Listing
January 2019
1 Read

Anorectal Cancer with Bone Marrow and Leptomeningeal Metastases.

Case Rep Oncol Med 2018 30;2018:9246139. Epub 2018 Dec 30.

Faculty of Medicine, Port Said University, Egypt.

This is an interesting case of anorectal signet ring carcinoma with first presentation of an early stage disease, showing the aggressive disease and the undetectable behavior of this type of histology which can mislead diagnosis. Brain/CNS metastasis from colorectal cancer (CRC) is rare occurring in 3% of cases, and leptomeningeal carcinomatosis (LMC) is extremely rare in CRC (<0.02%). Read More

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https://www.hindawi.com/journals/crionm/2018/9246139/
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http://dx.doi.org/10.1155/2018/9246139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332972PMC
December 2018
4 Reads

[A Case of Rectal Neuroendocrine Carcinoma That Showed a Sharp Turning Point after Neoadjuvant Radiochemotherapy and Conversion Surgery].

Gan To Kagaku Ryoho 2018 Dec;45(13):2006-2008

Dept. of Surgery, Kanmon Medical Center.

A 45-year-old man presented with the chief complaint of anal discomfort to a previous doctor. The symptoms remained after undergoing seton surgery following the diagnosis of intermuscular anal fistula. CT showed a tumor that was 3 cm in diameter on the right wall of the rectum, and he received a diagnosis of neuroendocrine carcinoma(NEC)based on a biopsy. Read More

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December 2018
1 Read

[A Case of Extended Mediastinal and Retroperitoneal Emphysema after Transanal Local Excision of an Early Lower Rectal Adenocarcinoma].

Gan To Kagaku Ryoho 2018 Dec;45(13):1973-1975

Dept. of Surgery, Osaka Saiseikai Senri Hospital.

We observed a case of a large collection of mediastinal and retroperitoneal emphysema, which developed after a transanal local excision for an early lower rectal carcinoma and was treated conservatively. An 80's female patient presented with a chief complaint of bowel difficulty, which was diagnosed as mucosal prolapse syndrome with anal sphincter dysfunction. Endoscopic colonoscopy showed full circumferential proliferation of the mucosal membrane including a semicircular protruding lesion, on the upper side of the dentate line. Read More

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December 2018
4 Reads

[Intrahepatic Bile Duct Metastasis from Rectal Adenocarcinoma Eight Years after Curative Operation].

Gan To Kagaku Ryoho 2018 Dec;45(13):2084-2086

Dept. of Surgery, Shuuwa General Hospital.

A 60-year-old male undergoing pelvic evisceration with D3 lymph node dissection for pR0 in 2006f or carcinoma of the rectum was diagnosed pathologically with moderately differentiated adenocarcinoma, fStage ⅡA(UICC pT3, pN0, M0). Follow-up CT revealed hypovascular liver tumors with intrahepatic bile duct dilation in the right lobe 8 years after the pelvic evisceration. We conducted right lobe hepatectomy. Read More

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December 2018
2 Reads

Rectal adenocarcinoma presenting with thigh muscle metastasis as the only metastatic site.

BMJ Case Rep 2019 Jan 22;12(1). Epub 2019 Jan 22.

PET/CT, Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, The Islamic Republic of Iran.

Rectal carcinoma with metastasis to skeletal muscle is a rare finding. According to literature review, 17 cases of skeletal muscle metastasis from colorectal carcinoma have been documented where only six cases were rectal carcinomas.We discuss a case of a middle-aged man with a known history of high-grade mucinous adenocarcinoma of the rectum, status post abdominoperineal resection followed by adjuvant radiotherapy and chemotherapy. Read More

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http://dx.doi.org/10.1136/bcr-2018-226802DOI Listing
January 2019
2 Reads

The prevalence of germline DICER1 pathogenic variation in cancer populations.

Mol Genet Genomic Med 2019 Jan 22:e555. Epub 2019 Jan 22.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland.

Background: The DICER1 syndrome is an autosomal dominant tumor-predisposition disorder associated with pleuropulmonary blastoma, a rare pediatric lung cancer. Somatic missense variation in "hotspot" codons in the RNaseIIIb domain (E1705, D1709, G1809, D1810, E1813) is observed in DICER1-associated tumors. Previously, we found the prevalence of germline pathogenic DICER1 variation in the general population is 1:10,600. Read More

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http://dx.doi.org/10.1002/mgg3.555DOI Listing
January 2019
11 Reads

Genetic analysis of subsequent second primary malignant neoplasms in long-term pancreatic cancer survivors suggests new potential hereditary genetic alterations.

Cancer Manag Res 2019 10;11:599-609. Epub 2019 Jan 10.

Department of Oncology, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic,

Background: The principal aim of this report was to study second primary malignant neoplasms (SMNs) in long-term survivors of pancreatic ductal adenocarcinoma (PDAC) with regard to the germline genetic background.

Patients And Methods: A total of 118 PDAC patients after a curative-intent surgery who were treated between 2006 and 2011 were analyzed. Of the 22 patients surviving for >5 years, six went on to develop SMNs. Read More

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https://www.dovepress.com/genetic-analysis-of-subsequent-sec
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http://dx.doi.org/10.2147/CMAR.S185352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331079PMC
January 2019
2 Reads

Preservation of Denonvilliers' fascia for nerve-sparing laparoscopic total mesorectal excision: A neuro-histological study.

Clin Anat 2019 Jan 21. Epub 2019 Jan 21.

Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Urogenital complications due to pelvic autonomic nerve damage frequently occur following rectal surgery. We investigated whether total mesorectal excision (TME) with preservation of the Denonvilliers' fascia (DVF) can effectively prevent the removal of pelvic autonomic nerves through microscopy. Twenty consecutive male patients with mid-low rectal cancer who received TME with preservation or resection of the Denonvilliers' fascia (P and R groups, respectively) were included. Read More

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http://dx.doi.org/10.1002/ca.23336DOI Listing
January 2019
5 Reads
1.159 Impact Factor

Interaction between C2ORF68 and HuR in human colorectal cancer.

Oncol Rep 2019 Mar 21;41(3):1918-1928. Epub 2019 Jan 21.

Department of Human Anatomy, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

The detailed molecular mechanisms underlying the carcinogenesis of colorectal carcinoma (CRC) remain unknown. Therefore, the present study was designed to investigate the effect of the relationship between C2ORF68 and HuR in regards to the carcinogenesis of CRC. Immunohistochemistry, immunofluorescence, flow cytometry, Transwell migration and CCK‑8 assays, co‑immunoprecipitation, qRT‑PCR and western blot analysis were performed. Read More

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http://www.spandidos-publications.com/10.3892/or.2019.6973
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http://dx.doi.org/10.3892/or.2019.6973DOI Listing
March 2019
6 Reads
2.191 Impact Factor

Colon Metastasis From Microscopic Serous Carcinoma of the Fallopian Tube Fimbria Mimicking a Primary Colon Cancer.

Int J Surg Pathol 2019 Jan 20:1066896918824028. Epub 2019 Jan 20.

1 NTT Medical Center Tokyo, Tokyo, Japan.

Metastatic diseases rarely develop in the colorectum, and diagnosing colorectal metastasis by biopsy without history of a malignant tumor or clinical information of a primary tumor is challenging. A 65-year-old woman with a 6-month history of constipation and diarrhea was admitted to our hospital and diagnosed with rectosigmoid colonic micropapillary carcinoma. Low anterior resection was performed after neoadjuvant chemotherapy. Read More

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http://journals.sagepub.com/doi/10.1177/1066896918824028
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http://dx.doi.org/10.1177/1066896918824028DOI Listing
January 2019
13 Reads

Diagnostic performance of magnetic resonance to assess treatment response after neoadjuvant therapy in patients with locally advanced rectal cancer.

Abdom Radiol (NY) 2019 Jan 21. Epub 2019 Jan 21.

Department of Surgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, Brazil.

Purpose: Our study aimed to evaluate the diagnostic performance of rectal magnetic resonance imaging (MRI) for local restaging in patients with non-metastatic locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (CRT) using surgical histopathology of total mesorectal excision as the reference standard.

Methods: Ninety-five patients with LARC who underwent rectal MRI after CRT between January 2014 and December 2016 were included. Accuracy, sensitivity, specificity, positive, and negative predictive value for local staging regarding T-stage, N-stage, circumferential resection margin, and MRI tumor regression grade (ymriTRG) were calculated, and inter-test agreements were assessed. Read More

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http://dx.doi.org/10.1007/s00261-019-01894-8DOI Listing
January 2019
2 Reads

Brachytherapy for localized prostate cancer in the modern era: a comparison of patient-reported quality of life outcomes among different techniques.

J Contemp Brachytherapy 2018 Dec 28;10(6):495-502. Epub 2018 Dec 28.

Department of Radiation Oncology.

Purpose: To report our institutional quality of life (QOL) data for low-dose-rate (LDR) monotherapy (LDR mono), high-dose-rate (HDR) monotherapy (HDR mono), and EBRT with an HDR brachytherapy boost (HDR boost).

Material And Methods: The charts of 165 patients with localized adenocarcinoma of the prostate treated with LDR monotherapy (LDR mono), HDR monotherapy (HDR mono), and EBRT with an HDR brachytherapy boost (HDR boost) at a single institution between 2012 and 2015 were reviewed. All patients completed the American Urological Association symptom score (AUASS) and Expanded Prostate Index for Prostate Cancer - Clinical Practice (EPIC-CP) quality of life assessments prior to treatment and at least one follow-up survey. Read More

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https://www.termedia.pl/doi/10.5114/jcb.2018.81024
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http://dx.doi.org/10.5114/jcb.2018.81024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335553PMC
December 2018
5 Reads

Pathological nodal staging score for rectal cancer patients treated with radical surgery with or without neoadjuvant therapy: a postoperative decision tool.

Cancer Manag Res 2019 7;11:537-546. Epub 2019 Jan 7.

Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China,

Background: Lymph node status can predict the prognosis of patients with rectal cancer treated with surgery. Thus, we sought to establish a standard for the minimum number of lymph nodes (LNs) examined in patients with rectal cancer by evaluating the probability that pathologically negative LNs prove positive during surgery.

Patients And Methods: We extracted information of 31,853 patients with stage I-III rectal carcinoma registered between 2004 and 2013 from the Surveillance, Epidemiology, and End Results database and divided them into two groups: the first group was SURG, including patients receiving surgery directly and the other group was NEO, encompassing those underwent neo-adjuvant therapy. Read More

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https://www.dovepress.com/pathological-nodal-staging-score-f
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http://dx.doi.org/10.2147/CMAR.S169309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327887PMC
January 2019
6 Reads

Primary urothelial carcinoma of the prostate: A rare case report.

Medicine (Baltimore) 2019 Jan;98(3):e14155

Department of Urology, The First Affiliated Hospital of Anhui Medical University.

Rationale: Prostatic urothelial carcinoma is a rare disease. Medical misdiagnosis rates remain high because there are no specific clinical symptoms or imaging features, which decreases patient survival. We report a case of prostatic urethral cancer confirmed by transrectal ultrasound-guided prostate biopsy because of an abnormal digital rectal exam. Read More

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http://dx.doi.org/10.1097/MD.0000000000014155DOI Listing
January 2019
1 Read
5.723 Impact Factor

[Sigmoid intussusception as a clinical presentation of colonic schwannoma: Pediatric case].

Arch Argent Pediatr 2019 02;117(1):e68-e71

Servicio de Cirugía Pediátrica, Hospital Universitario Miguel Servet, Zaragoza, España.

Schwannomas are tumours originating in the Schwann cells of the peripheral nerves. The appearance in the colon is extremely rare, and there are no known cases in the literature of schwannomas of the colon and rectum described in children. These tumours are usually asymptomatic, but can produce non-specific and gastrointestinal symptoms. Read More

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http://dx.doi.org/10.5546/aap.2019.e68DOI Listing
February 2019
1 Read

Tumor location as an indication for adjuvant radiotherapy in pT3N0 rectal cancer after surgery.

Radiat Oncol 2019 Jan 16;14(1). Epub 2019 Jan 16.

Department of Radiation Oncology, SunYat-Sen Memorial Hospital, SunYat-Sen University, Guangzhou, China.

Background: The optimal care for pT3N0 rectal cancer remains controversial. And whether tumor location can be used to guide the administration of adjuvant radiotherapy for pT3N0 rectal cancer is not fully confirmed. The current study was designed to identify the benefit of adjuvant radiotherapy for pT3N0 rectal cancer. Read More

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http://dx.doi.org/10.1186/s13014-019-1206-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334427PMC
January 2019
2 Reads

Erythema Gyratum Repens Associated with Anal Cancer.

N Engl J Med 2019 Jan;380(3):e3

University of Kansas Medical Center, Kansas City, KS

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http://www.nejm.org/doi/10.1056/NEJMicm1805833
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http://dx.doi.org/10.1056/NEJMicm1805833DOI Listing
January 2019
5 Reads

The TNM 8th edition: Validation of the proposal for organ - confined (pT2) prostate cancer.

Int Braz J Urol 2018 Nov 30;45. Epub 2018 Nov 30.

Departmento de Urologia da Faculdade de Ciências Médicas da Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brasil.

Purpose: The 8th edition of the TNM has been updated and improved in order to ensure a high degree of clinical relevance. A major change in prostate includes pathologically organ - confined disease to be considered pT2 and no longer subclassified by extent of involvement or laterality. The aim of this study was to validate this major change. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0338DOI Listing
November 2018
1 Read

Nomograms for predicting pathological response to neoadjuvant treatments in patients with rectal cancer.

World J Gastroenterol 2019 Jan;25(1):118-137

Department of Colorectal Surgery, Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, Guangdong Province, China.

Background: In recent decades, neoadjuvant therapy (NT) has been the standardized treatment for locally advanced rectal cancer (LARC). Approximately 8%-35% of patients with LARC who received NT were reported to have achieved a complete pathological response (pCR). If the pathological response (PR) can be accurately predicted, these patients may not need surgery. Read More

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http://dx.doi.org/10.3748/wjg.v25.i1.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328965PMC
January 2019
7 Reads

[Laparoscopy combined with total intersphincteric resection for extremely low rectal cancer].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Nov;43(11):1223-1229

Department of Hepatobiliary and Enteric Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To investigate the feasibility and therapeutic effect of laparoscopy combined with total intersphincteric resection (Total-ISR) for extremely low rectal cancer.
 Methods: We performed laparoscopy combined with Total-ISR in 45 patients with extremely low rectal cancer (1.0 cm≤the lower edge of tumor to the anal edge≤3. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.11.009DOI Listing
November 2018
2 Reads

[Pseudocontinent perineal colostomy: an exceptional complication].

Pan Afr Med J 2018 7;30:258. Epub 2018 Aug 7.

Service de Chirurgie Viscérale, Département de Chirurgie Digestive et Endocrinienne, Centre Hospitalier Universitaire Hassan II de FES, Maroc.

Stoma prolapse is an exceptional and late complication of pseudocontinent perineal colostomy. Very rare cases have been described in the literature. We here report the case of a 75 year old patient with no particular past medical history as well as our therapeutic approach. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.258.15294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317292PMC
January 2019
1 Read

Primary Colorectal Follicular Lymphoma in 3 Dogs.

Vet Pathol 2019 Jan 13:300985818823775. Epub 2019 Jan 13.

1 Department of Pathobiology and Diagnostic Investigation, Veterinary Diagnostic Laboratory, Michigan State University, Lansing, MI, USA.

Primary colorectal follicular lymphomas are rare indolent lymphoid neoplasms in humans that have not been reported in dogs. We describe 3 cases of primary colorectal follicular lymphoma in dogs with histologic and immunohistochemical features similar to their human counterpart. Initial clinical signs in all dogs included tenesmus, hematochezia, and a palpable rectal mass. Read More

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http://dx.doi.org/10.1177/0300985818823775DOI Listing
January 2019
2 Reads

Robotic versus laparoscopic surgery for rectal cancer: an overview of systematic reviews with quality assessment of current evidence.

Surg Today 2019 Jan 11. Epub 2019 Jan 11.

Department of Surgery, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan.

Purpose: The clinical benefits of robotic surgery for patients with rectal cancer have been reported and many systematic reviews have been published. However, they have investigated a variety of outcomes and differ remarkably in quality. In this overview, we summarize the findings of these reviews and evaluate their quality. Read More

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http://dx.doi.org/10.1007/s00595-019-1763-yDOI Listing
January 2019
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Surgery and chemotherapy are associated with improved overall survival in anal adenocarcinoma: results of a national cohort study.

Int J Colorectal Dis 2019 Jan 11. Epub 2019 Jan 11.

Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA.

Purpose: Anal adenocarcinoma (AAC) is a rare disease with treatment protocols that mimic both that of rectal adenocarcinoma (RAC) and anal squamous cell carcinoma (ASCC). Due to its rarity, data regarding outcomes are lacking. We sought to determine outcomes of patients with AAC compared to RAC and ASCC and to evaluate risk factors for mortality in AAC. Read More

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http://dx.doi.org/10.1007/s00384-018-03232-8DOI Listing
January 2019
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Rechallenge capecitabine after fluoropyrimidine-induced cardiotoxicity in rectal cancer: A case report.

Medicine (Baltimore) 2019 Jan;98(2):e14057

Rationale: Fluoropyrimidine-induced cardiotoxicity is a rare but potentially serious toxicity. The most common symptom is anginal chest pain.

Patient Concerns: A 35-year-old woman was diagnosed with rectal cancer with metastasis to the liver. Read More

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http://dx.doi.org/10.1097/MD.0000000000014057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336628PMC
January 2019
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Rubber Band Ligation of Hemorrhoids is often a Necessary Complement in the Management of Hemorrhagic Radiation Proctitis.

Scand J Surg 2019 Jan 11:1457496918822619. Epub 2019 Jan 11.

1 Department of Colorectal Surgery, Royal Prince Alfred Hospital, Sydney, NSW, Australia.

Background:: Management of radiation proctitis presents a treatment challenge. Limited data exist on the management of symptomatic hemorrhoids in radiated patients. This study aims to present a practical approach to the management of radiation proctitis, particularly in patients with synchronous hemorrhoids. Read More

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http://dx.doi.org/10.1177/1457496918822619DOI Listing
January 2019
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TTF1 Expression in Pulmonary Metastatic Rectal Adenocarcinoma.

Case Rep Gastrointest Med 2018 5;2018:6405125. Epub 2018 Dec 5.

Department of Medical Biotechnologies, Section of Pathology, University of Siena, 53100 Siena, Italy.

Thyroid transcription factor (TTF-1) is a tissue-specific nuclear transcription factor expressed developing thyroid, respiratory epithelium, and diencephalon. TTF-1 is thought to be expressed specifically in most thyroid tumors and in a significant subset of pulmonary neoplasms. However, recent studies on its expression in extrapulmonary carcinomas have demonstrated that TTF-1 is not as specific for lung and thyroid carcinomas as was previously thought: positivity of this marker can be observed, although much less frequently, in some carcinomas arising in other organs, such as the ovaries, endometrium, colon, and breast, as well as in some tumors of the central nervous system. Read More

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http://dx.doi.org/10.1155/2018/6405125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304559PMC
December 2018
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Efficacy and toxicity of chemoradiation with image-guided adaptive brachytherapy for locally advanced cervical cancer.

Int J Gynecol Cancer 2019 Jan 10. Epub 2019 Jan 10.

Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands.

Objective: To evaluate the efficacy and toxicity of primary chemoradiation with image-guided adaptive brachytherapy for locally advanced cervical cancer and to identify predictors of treatment failure and toxicity.

Methods: Retrospective analysis of 155 stage IB-IVA cervical cancer patients treated from 2008 to 2016 with chemoradiation and image-guided adaptive brachytherapy. Treatment consisted of external beam radiotherapy (45 - 48. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000057DOI Listing
January 2019
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Descriptive analysis of colorectal cancer in Zambia, Southern Africa using the National Cancer Disease Hospital Database.

Pan Afr Med J 2018 6;30:248. Epub 2018 Aug 6.

Cancer Disease Hospital (CDH), Lusaka, Zambia.

Introduction: Colon cancer is preventable. There is a plethora of data regarding epidemiology and screening guidelines, however this data is sparse from the African continent. Objective: we aim to evaluate the trends of colorectal cancer (CRC) in a native African population based on age at diagnosis, gender and stage at diagnosis. Read More

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http://www.panafrican-med-journal.com/content/article/30/248
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http://dx.doi.org/10.11604/pamj.2018.30.248.12464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307926PMC
January 2019
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New 1,2,4-Oxadiazole Nortopsentin Derivatives with Cytotoxic Activity.

Mar Drugs 2019 Jan 8;17(1). Epub 2019 Jan 8.

Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, via Archirafi 32, 90123 Palermo, Italy.

New analogs of nortopsentin, a natural 2,4-bis(3'-indolyl)imidazole alkaloid, in which the central imidazole ring of the natural lead was replaced by a 1,2,4-oxadiazole moiety, and in which a 7-azaindole portion substituted the original indole moiety, were efficiently synthesized. Among all derivatives, prescreened against the HCT-116 colon rectal carcinoma cell line, the two most active compounds were selected and further investigated in different human tumor cells showing IC values in the micromolar and submicromolar range. Flow cytometric analysis of propidium iodide-stained MCF-7 cells demonstrated that both the active derivatives caused cell cycle arrest in the G0⁻G1 phase. Read More

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http://dx.doi.org/10.3390/md17010035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357034PMC
January 2019
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Prognostic value of MRI in assessing extramural venous invasion in rectal cancer: multi-readers' diagnostic performance.

Eur Radiol 2019 Jan 7. Epub 2019 Jan 7.

Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.

Objectives: This study was conducted in order to determine the prognostic value of MRI for extramural venous invasion (EMVI) in rectal cancer compared to pathology and to assess the diagnostic performance of multireaders.

Methods: We retrospectively enrolled 222 patients (M:F = 148:74; mean age ± standard deviation, 61.5 ± 12 years) with histopathologically proven rectal cancers who underwent preoperative MRI between 2007 and 2016. Read More

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http://dx.doi.org/10.1007/s00330-018-5926-9DOI Listing
January 2019

The adipofasciocutaneous gluteal fold perforator flap a versatile alternative choice for covering perineal defects.

Int J Colorectal Dis 2019 Jan 4. Epub 2019 Jan 4.

Department of Plastic and Hand Surgery, Faculty of Medicine, University of Freiburg, im Breisgau, Germany.

Aim: Perineal defects following the resection of anorectal malignancies are a reconstructive challenge. Flaps based on the rectus abdominis muscle have several drawbacks. Regional perforator flaps may be a suitable alternative. Read More

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http://dx.doi.org/10.1007/s00384-018-03222-wDOI Listing
January 2019

Detailed Pathological Analysis of the Advancing Edge of the Tumor Can Effectively Stratify Clinical T4b Colorectal Cancer Patients.

Histopathology 2019 Jan 4. Epub 2019 Jan 4.

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Aims: Pathological staging of colorectal cancers (CRCs) that involve adhesion to adjacent organs (clinical stage T4b, cT4b) is sometimes difficult because the morphology of the invasive front varies. To resolve this issue, we reviewed 492 surgically resected CRC samples, comprising 96 cT4b tumors and, for comparison, 335 typical pathological stage (p) T3 and 61 pT4a tumors.

Methods And Results: Cases were subdivided into four groups according to the presence or absence of microscopic tumor invasion into the muscular wall of the adjacent organs and peri-tumoral abscess along invasive front. Read More

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http://dx.doi.org/10.1111/his.13820DOI Listing
January 2019
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A CARE-compliant article: a case report of primary adenocarcinoma of the anal glands: Review of literature.

Authors:
Yong Ji Youxin Zhou

Medicine (Baltimore) 2019 Jan;98(1):e13877

Department of General Surgery, People Hospital of Jingjiang, YangZhou University Medical Academy, Jingjiang, Taizhou, China.

Rationale: Adenocarcinoma of the anal canal is an uncommon malignancy. Primary adenocarcinoma, in particular, is extremely rare.

Patient Concerns: A 61-year-old man was referred to our institution with complaints of repeated hematochezia. Read More

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http://dx.doi.org/10.1097/MD.0000000000013877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344196PMC
January 2019

[A case of antisynthetase syndrome with anti-EJ antibody complicated by pericarditis].

Rinsho Shinkeigaku 2019 Jan 29;59(1):21-26. Epub 2018 Dec 29.

Department of Neurology, Nitobe Memorial Nakano General Hospital.

A 69-year-old man was admitted with neck muscle weakness, symmetric proximal muscle weakness, skin rash and elevated serum creatine kinase levels. Muscle biopsy showed perifascicular necrosis and perimysial alkaline phosphatase activity. Chest CT revealed interstitial lung disease and colorectal cancer was diagnosed on colonoscopy. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001140DOI Listing
January 2019
10 Reads