61,911 results match your criteria Rectal Carcinoma


Progression of anal intraepithelial neoplasia in HIV-positive individuals: predisposing factors.

Tech Coloproctol 2019 Apr 23. Epub 2019 Apr 23.

Department of General Surgery, Section of Colon and Rectal Surgery, Vanderbilt University Medical Center, 1161 21st Ave South, Room D5248 MCN, Nashville, TN, 37232, USA.

Background: The aim of the present study was to evaluate patient factors that affect the progression of anal dysplasia in human immunodeficiency virus (HIV)-positive individuals.

Methods: A retrospective cohort study of HIV-positive adults with human papilloma virus related anal lesions was performed from 2012 to 2017. All patients underwent surgical excision or biopsy and fulguration of lesions in the operating room without using high resolution anoscopy. Read More

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http://dx.doi.org/10.1007/s10151-019-01951-wDOI Listing

Extended-spectrum β-lactamase in the rectal flora of patients undergoing transrectal prostate biopsy: a study of the prevalence in a major metropolitan hospital.

BJU Int 2019 Apr 23. Epub 2019 Apr 23.

Department of Urology, Royal Melbourne Hospital, Parkville, Vic., Australia.

Objectives: To determine the prevalence of extended-spectrum β-lactamase (ESBL) in patients undergoing transrectal prostate biopsy, to assess the incidence of postoperative sepsis, to correlate the development of sepsis with the presence of preoperative ESBL on rectal swabs, and to assess the adequacy of prophylactic antibiotic guidelines in the context of local ESBL prevalence.

Methods: Patients undergoing transrectal ultrasonography (TRUS)-guided biopsy at the Royal Melbourne Hospital between January 2012 and July 2016 had rectal swabs taken immediately prior to TRUS with specific cultures to identify the presence of ESBL. Patients were given a prophylactic antibiotic, 500 mg oral ciprofloxacin, 1 h before the TRUS procedure. Read More

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http://dx.doi.org/10.1111/bju.14745DOI Listing

[Association between the frequency of bowel movements and the risk of colorectal cancer in Chinese adults].

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Apr;40(4):382-388

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.

To examine the association between the frequencies of bowel movement (BMF) and the risk of colorectal cancer (CRC). In this study, 510 134 participants from the China Kadoorie Biobank (CKB) were included, after excluding those who reported as having been diagnosed with cancer at the baseline survey. The baseline survey was conducted from June 2004 to July 2008. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.04.003DOI Listing

Comparison of overall survival and quality of life between patients undergoing anal reconstruction and patients undergoing traditional lower abdominal stoma after radical resection.

Clin Transl Oncol 2019 Apr 20. Epub 2019 Apr 20.

The Department of General Surgery, Second Hospital of Lanzhou University, No. 82, Cuiying Gate, Chengguan District, Lanzhou, 730030, Gansu, China.

Background: Miles procedure is often necessary for patients with low rectal carcinoma. However, this operation often affects the quality of life of patients, to evaluate the advantages of improved operation (anal reconstruction), the quality of life and survival between patients undergoing anal reconstruction and patients undergoing traditional lower abdominal stoma after radical resection were analyzed.

Methods: The clinical data of 43 patients with low situated rectal carcinoma were retrospectively analyzed. Read More

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http://dx.doi.org/10.1007/s12094-019-02106-xDOI Listing

Long-term results of a multicenter phase II study of preoperative chemoradiotherapy with S-1 plus oxaliplatin for locally advanced rectal cancer (JACCRO CC-04: SHOGUN Trial).

Radiother Oncol 2019 May 26;134:199-203. Epub 2019 Feb 26.

Japan Clinical Cancer Research Organization, Tokyo, Japan.

Purpose: The study was designed to evaluate the safety and efficacy of adding oxaliplatin to py (CRT) with S-1 in patients with locally advanced rectal carcinoma (LARC). We report here the final results of the study.

Patients And Methods: Patients with histopathologically confirmed LARC (cT3-T4, any N) were eligible. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.02.006DOI Listing
May 2019
4 Reads

Mucin-Containing Rectal Carcinomas: Overview of Unique Clinical and Imaging Features.

AJR Am J Roentgenol 2019 Apr 17:1-9. Epub 2019 Apr 17.

3 Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI.

The purpose of this study is to review the unique clinical and imaging features of mucin-containing rectal carcinomas. Mucinous rectal carcinoma is an uncommon tumor subtype with a worse prognosis. At MRI, it is marked by T2-hyperintense extracellular mucin. Read More

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https://www.ajronline.org/doi/10.2214/AJR.18.20864
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http://dx.doi.org/10.2214/AJR.18.20864DOI Listing
April 2019
1 Read

Mucinous rectal cancer: concepts and imaging challenges.

Abdom Radiol (NY) 2019 Apr 16. Epub 2019 Apr 16.

Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 29, New York, NY, 10065, USA.

Rectal adenocarcinoma with mucinous components is an uncommon type of rectal cancer with two distinct histologic subtypes: mucinous adenocarcinoma and signet-ring cell carcinoma. Mucin can also be identified as pattern of response after neoadjuvant treatment. On imaging modalities, mucin typically demonstrates high signal intensity on T2-weighted images, low attenuation on computed tomography, and may be negative on 18-fluorodeoxyglucose positron emission tomography. Read More

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http://dx.doi.org/10.1007/s00261-019-02019-xDOI Listing

Colorectal Large Cell Neuroendocrine Carcinoma with lymphoid stroma: further evidence confirming a unique sub-type associated with MLH-1/PMS2 protein loss, BRAF mutation, EBV-negativity and possible better prognosis.

Histopathology 2019 Apr 16. Epub 2019 Apr 16.

University Health Network and University of Toronto, Toronto, Canada.

Pure large cell neuroendocrine carcinoma (LCNEC) is an uncommon but well recognized primary tumour of the colorectum. It is characterized by large cells organized in a discernible neuroendocrine pattern, >20 mitoses per 10 HPF and/or Ki-67 index > 20% and, coagulative tumour necrosis is invariably present. These features are supplemented by positive neuroendocrine immunohistochemical markers. Read More

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http://dx.doi.org/10.1111/his.13875DOI Listing
April 2019
1 Read

Solitary adrenal metastasis from advanced gastric cancer invading duodenal bulb with situs inversus totalis: A case report.

Medicine (Baltimore) 2019 Apr;98(15):e15244

Department of the General Surgery.

Rationale: Situs invsersus totalis (SIT) is a rare anomaly featured by complete inversion of abdominal and thoracic organs. Adrenal metastasis is often encountered as part of advanced systemic dissemination, which is usually unresectable. Few published cases reported the adrenal metastasis from gastric cancer with SIT and the treatment of gastrectomy combined with adrenalectomy, especially with intraoperative radiotherapy (IORT). Read More

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http://dx.doi.org/10.1097/MD.0000000000015244DOI Listing
April 2019
1 Read

Neoadjuvant Radiochemotherapy Significantly Alters the Phenotype of Plasmacytoid Dendritic Cells and 6-Sulfo LacNAc Monocytes in Rectal Cancer.

Front Immunol 2019 29;10:602. Epub 2019 Mar 29.

Institute of Immunology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Neoadjuvant radiochemotherapy (nRCT) can significantly influence the tumor immune architecture that plays a pivotal role in regulating tumor growth. Whereas, various studies have investigated the effect of nRCT on tumor-infiltrating T cells, little is known about its impact on the frequency and activation status of human dendritic cells (DCs). Plasmacytoid DCs (pDCs) essentially contribute to the regulation of innate and adaptive immunity and may profoundly influence tumor progression. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450462PMC
March 2019
1 Read

Association between oncogenic RAS mutation and radiologic-pathologic findings in patients with primary rectal cancer.

Quant Imaging Med Surg 2019 Feb;9(2):238-246

Department of Radiology, Inje University College of Medicine, Haeundae Paik Hospital, Haeundae-gu, Busan, Korea.

Background: To evaluate the association between various radiologic-pathologic findings and oncogenic Kirsten-ras (KRAS) mutation in patients with primary rectal cancer.

Methods: Seventy-five patients with primary rectal cancer who had undergone rectal magnetic resonance imaging (MRI) were included. The rectal MRI consisted of T2-weighted images in three planes, pre- and post-contrast-enhanced T1-weighted images, and axial diffusion-weighted images (b factors, 0, 1,000 s/mm). Read More

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http://dx.doi.org/10.21037/qims.2018.12.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414762PMC
February 2019
1 Read

Prospective Study of Isolated Recurrent Tumor Re-irradiation With Carbon-Ion Beams.

Front Oncol 2019 27;9:181. Epub 2019 Mar 27.

Gunma University Heavy Ion Medical Center, Maebashi, Japan.

To perform a prospective study to evaluate the efficacy and safety of isolated recurrent tumor re-irradiation with carbon-ion radiotherapy (RT). The inclusion criteria were clinically proven recurrent tumors, measurable by computed tomography or magnetic resonance imaging, patients ≥ 16 years old, performance status scores between 0 and 2, isolated tumor at a previously irradiated site, and a life expectancy > 6 months. The exclusion criteria were tumor invasion into the gastrointestinal tract or a major blood vessel, uncontrolled infection, early recurrence (<3 months), and severe concomitant diseases. Read More

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http://dx.doi.org/10.3389/fonc.2019.00181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445888PMC
March 2019
2 Reads

[Preoperative prediction for lymph node metastasis of rectal nonmucinous adenocarcinoma based on radiomics classifier].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2019 Mar;44(3):271-276

Department of Radiology, Hunan Provincial People's Hospital, First Affiliated Hospital of Hunan Normal University, Changsha 410005, China.

Objective: To determine the value of radiomics in identifying lymph node (LN) metastasis in patients with rectal nonmucinous adenocarcinoma.
 Methods: Imaging data of 91 patients were retrospectively analyzed (61 in the training set and 30 in the test set). A total of 1 301 radiomics features were extracted from high-resolution T2-weighted images of the whole primary tumor. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2019.03.007DOI Listing
March 2019
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The prognosis value of EphA3 and the androgen receptor in prostate cancer treated with radical prostatectomy.

J Clin Lab Anal 2019 Apr 8:e22871. Epub 2019 Apr 8.

Department of Clinical Laboratory, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Background: This study aimed to preliminarily assess the relationship between erythropoietin-producing hepatocellular carcinoma receptor A3 (EphA3) and androgen receptor (AR) protein expression levels and prognosis in prostate cancer (PCa) to better understand the role of EphA3 in the prognosis and progression of PCa.

Materials: We investigated the expression of EphA3 and AR in human PCa by immunohistochemistry.

Results: EphA3 and AR were both significantly upregulated in PCa, with expression mainly localized to the nucleus. Read More

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http://dx.doi.org/10.1002/jcla.22871DOI Listing
April 2019
1 Read

[Clinicopathological significance of poorly differentiated clusters in colorectal adenocarcinoma].

Zhonghua Bing Li Xue Za Zhi 2019 Apr;48(4):276-281

Department of Pathology, Nanjing Hospital(Nanjing First Hospital), Nanjing Medical University, Nanjing 210006, China.

To investigate the correlation between poorly differentiated clusters (PDCs) in colorectal adenocarcinomas with clinicopathological parameters and its clinicopathological significance. One hundred and eighty-three colorectal adenocarcinomas resected by radical proctocolecomy were collected at Nanjing Hospital(Nanjing First Hospital), Nanjing Medical University, from January to December 2017. There were 122 male and 61 female patients with age ranging from 42 to 89 years (mean of 68 years). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.04.003DOI Listing
April 2019
2 Reads

Association of Statin Use and Oncological Outcomes After Neoadjuvant Radiotherapy in Patients With Rectal Cancer.

Anticancer Res 2019 Apr;39(4):2177-2182

Department of Surgery, Zealand University Hospital, Køge, Denmark.

Aim: The aim of the study was to examine if statin exposure during neoadjuvant chemoradiotherapy improves oncological outcomes in patients with rectal cancer.

Patients And Methods: The study cohort consisted of patients who were undergoing neoadjuvant chemoradiotherapy and resection for rectal cancer. The statin users were matched 1:1 with non-users using propensity score-based matching. Read More

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http://dx.doi.org/10.21873/anticanres.13332DOI Listing
April 2019
2 Reads

Comparison of Different Nodal Staging in Patients With Locally Advanced Mid-low Rectal Cancer After Long-term Neoadjuvant Chemoradiation Therapy.

Anticancer Res 2019 Apr;39(4):2113-2120

Unit of Digestive, Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Henri Mondor Hospital, AP-HP, University of Paris Est, UPEC, Créteil, France

Background/aim: The aim of this study was to compare the ability of different lymph nodal staging systems to predict cancer recurrence in a multicenter European series of patients who underwent proctectomy after neoadjuvant chemoradiotherapy for locally advanced rectal cancer.

Patients And Methods: Data on 170 consecutive patients undergoing proctectomy after neoadjuvant therapy for cT3-4 or cN+ rectal adenocarcinoma were retrieved from the European MRI and Rectal Cancer Surgery database. The prognostic role of the number of retrieved and examined nodes, nodal ratio, and log odds of positive lymph nodes (LODDS) was analyzed and compared by receiver operating characteristic curves, Pearson test, and univariate and multivariate analysis. Read More

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http://dx.doi.org/10.21873/anticanres.13324DOI Listing
April 2019
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Development of a Vaginal Immobilization Device: A Treatment-planning Study of Carbon-ion Radiotherapy and Intensity-modulated Radiation Therapy for Uterine Cervical Cancer.

Anticancer Res 2019 Apr;39(4):1915-1921

Gunma University Heavy Ion Medical Center, Maebashi, Japan.

Aim: We developed a vaginal immobilization device for external radiotherapy in gynaecological malignancies and evaluated its bowel dose-reduction effect during carbon-ion radiotherapy (CIRT) and intensity-modulated radiation therapy (IMRT) in patients with cervical cancer.

Patients And Methods: Computed tomographic images obtained with and without the device in seven patients with cervical cancer were assessed. Treatment plans for CIRT and IMRT were generated, and dose-volume parameters (V, V, V, and D) of the rectum, sigmoidal colon, and bladder were evaluated. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13300DOI Listing
April 2019
2 Reads

Short-Term Outcomes of Robotic Laparoscopic Total Mesorectal Excision for Rectal Cancer: A Cohort Study.

Am Surg 2019 Mar;85(3):294-302

The aim of this study was to evaluate and compare the intestinal function recovery time and other short-term outcomes between robotic-assisted total mesorectal excision (R-TME) and laparoscopic total mesorectal excision (L-TME) for rectal cancer. This is a retrospective study using a prospectively collected database. Patients' records were obtained from Gansu Provincial Hospital between July 2015 and October 2017. Read More

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March 2019
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For Physicians Managing Voiding Dysfunction, Improving the Detection Rate of Early Prostate Cancer and Discrimination From Benign Prostatic Hyperplasia, in a Molecular Biomarker Aspects.

Int Neurourol J 2019 Mar 31;23(1):5-12. Epub 2019 Mar 31.

Department of Urology, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.

Prostate cancer (CaP) is the most common cancer diagnosed among men in the United States and the fifth most common cancer among men in Korea. Unfortunately, the early stages of CaP may have no symptoms. Thus, early detection is very important and physicians managing voiding dysfunction must have awareness about CaP. Read More

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http://dx.doi.org/10.5213/inj.1836262.131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449661PMC
March 2019
4 Reads

Metaplastic rectal adenocarcinoma into metastatic mucinous carcinoma on the buttock: The efficacy of immunohistochemistry.

J Dermatol 2019 Apr 1. Epub 2019 Apr 1.

Department of Dermatology, Kansai Medical University Medical Center, Osaka, Japan.

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http://dx.doi.org/10.1111/1346-8138.14873DOI Listing
April 2019
4 Reads

Network Mapping of Molecular Biomarkers Influencing Radiation Response in Rectal Cancer.

Clin Colorectal Cancer 2019 Feb 10. Epub 2019 Feb 10.

Department of Surgery & Cancer, Imperial College London, London, UK; St Mark's Hospital and Academic Institute, Harrow, London, UK. Electronic address:

Preoperative radiotherapy (RT) plays an important role in the management of locally advanced rectal cancer (RC). Tumor regression after RT shows marked variability, and robust molecular methods are needed to help predict likely response. The aim of this study was to review the current published literature and use Gene Ontology (GO) analysis to define key molecular biomarkers governing radiation response in RC. Read More

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http://dx.doi.org/10.1016/j.clcc.2019.01.004DOI Listing
February 2019
2 Reads

A Monte Carlo study on the feasibility of real-time in vivo source tracking during ultrasound based HDR prostate brachytherapy treatments.

Phys Med 2019 Mar 26;59:30-36. Epub 2019 Feb 26.

Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia. Electronic address:

Purpose: This study aims to assess the accuracy of in-vivo source tracking during real-time trans-rectal ultrasound (TRUS) based high dose rate (HDR) prostate brachytherapy (pBT) through Monte Carlo simulations of multiple HDR pBT treatments with a two-dimensional (2D) diode array, the Magic Plate 900 (MP900), embedded below the patient in a carbon-fibre couch.

Method: Monte Carlo simulations of source positions representing three separate real-time TRUS based HDR pBT treatments were performed using the Geant4 toolkit. For each source position, an Ir-192 source was simulated inside a voxelized patient geometry. Read More

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http://dx.doi.org/10.1016/j.ejmp.2019.02.012DOI Listing
March 2019
1 Read

Radiogenomics of rectal adenocarcinoma in the era of precision medicine: A pilot study of associations between qualitative and quantitative MRI imaging features and genetic mutations.

Eur J Radiol 2019 Apr 18;113:174-181. Epub 2019 Feb 18.

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

Objective: To investigate associations between genetic mutations and qualitative as well as quantitative features on MRI in rectal adenocarcinoma at primary staging.

Methods: In this retrospective study, patients with rectal adenocarcinoma, genome sequencing, and pretreatment rectal MRI were included. Statistical analysis was performed to evaluate associations between qualitative features obtained from subjective evaluation of rectal MRI and gene mutations as well as between quantitative textural features and gene mutations. Read More

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http://dx.doi.org/10.1016/j.ejrad.2019.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443100PMC
April 2019
1 Read

[Short-term outcomes of robot-assisted transanal total mesorectal excision].

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Mar;22(3):267-272

Department of General Surgery, Daping Hospital, Army Medical university, Chongqing 400042, China, Email:

Objective: To explore the feasibility and safety of Da Vinci robot-assisted transanal total mesorectal excision (taTME).

Methods: From May 2017 to July 2018, six rectal cancer patients underwent Da Vinci robot-assisted taTME at our hospital. The clinical data and short-term follow-up results were retrospectively analyzed. Read More

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March 2019
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[Long-term efficacy of laparoscope-assisted transanal total mesorectal excision for rectal cancer].

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Mar;22(3):262-266

Department of Gastrointestinal Surgery, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China.

Objective: To investigate the long-term outcome of laparoscope-assisted transanal total mesorectal excision (taTME) for rectal cancer.

Methods: Clinicopathological data of 29 patients with mid-low rectal cancer undergoing laparoscope-assisted taTME at Department of Gastrointestinal Surgery, the First Affiliated Hospital of Guangzhou Medical University from May 2010 to December 2015 were collected for the retrospective case-series study. All the operations were performed with transabdominal and transanal procedure simultaneously or sequentially. Read More

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March 2019
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[Postoperative short-term complications of laparoscope-assisted transanal total mesorectal excision for rectal cancer after neoadjuvant therapy and their management: a single center report].

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Mar;22(3):255-261

Department 3 of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China, Email:

Objective: To summarize and analyze the postoperative short-term complications of laparoscope-assisted transanal total mesorectal excision (taTME) for rectal cancer patients after neoadjuvant therapy.

Methods: A prospectively established database on taTME patients at Peking University Cancer Hospital was screened with the following conditions: data retrieval from June 2016 to August 2018, pathologically confirmed adenocarcinoma, receiving preoperative neoadjuvant chemoradiotherapy or chemotherapy. The transabdominal procedure and the transanal procedure were performed simultaneously in the taTME operation. Read More

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March 2019
1 Read

[Comparison of postoperative bowel function between patients undergoing transanal and laparoscopic total mesorectal excision].

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Mar;22(3):246-254

Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China, Email:

Objective: To compare the effects of transanal total mesorectal excision (taTME) and laparoscopic total mesorectal excision (laparoscopic TME) on patients' postoperative long-term bowel function.

Methods: A retrospective cohort study was used in this study. We analyzed the clinical data of 134 patients with locally advanced mid-low rectal cancer, who underwent transanal TME or laparoscopic TME in the TaLaR randomized controlled trial at the Sixth Affiliated Hospital, Sun Yat-sen University from April 2016 to November 2017. Read More

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[Last critical step for transanal total mesorectal excision: anastomosis].

Authors:
Jianzhi Chen

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Mar;22(3):238-241

Department of Surgery, Koo Foundation, Sun Yat-Sen Cancer Center, Taipei, Taiwan 112, China, Email:

Colorectal anastomosis remains a key aspect in mid- and lower-rectal surgery, particularly in patients who are male, obese, status post neoadjuvant chemoradiation, or possess narrow pelvic anatomy. Transanal total mesorectal excision (taTME) and transabdominal total mesorectal excision (TME) both primarily allow position of the tumor to dictate whether circular stapling or hand-sewing is utilized to achieve anastomosis. Given that taTME only requires a single circular stapler to achieve anastomosis, it consequently decreases the risk of jeopardizing blood supply to the anastomotic site. Read More

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March 2019
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[Mechanism and prevention of urethral injury during transanal total mesorectal excision].

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Mar;22(3):233-237

Department of Colorectal Tumor Surgery, Shengjing Hospital, China Medical University, Shenyang 110004, China, Email:haojiubujian1203@ sina.cn.

In recent years, transanal total mesorectal excision (taTME) has become one of the focuses of colorectal surgery, but it still faces some controversial problems that have not been solved, such as urethral injury as a typical complication. This paper, from the perspective of urological and rectal surgery respectively, elucidates the current research progress on the anatomy between the rectum and urethra. From the perspective of urethral anatomy, the main structure involving urethral injury in taTME surgery is the rectourethral muscle, which actually is part of the longitudinal muscle of the rectum from the perspective of rectal anatomy. Read More

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[Investigation on the integrity of mesorectal specimens of transanal total mesorectal excision].

Authors:
Junyang Lu Yi Xiao

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Mar;22(3):228-232

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China, Email:

Total mesorectal excision (TME) has become the gold standard for mid-low rectal cancer surgery. However, for some patients with obesity and narrow pelvis, there are great challenges in both open and laparoscopic surgery. Transanal total mesorectal excision (taTME) uses a transanal approach, in " bottom-up" direction, which reduces the difficulty of distal mesorectal excision and may improve the quality of the TME specimen. Read More

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[Transanal total mesorectal excision and organ function preservation].

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Mar;22(3):224-227

Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Laboratory of General Surgery, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People's Hospital, Peking 100044, China.

Thanks to endoscopic assistance and the pressure effect of pelvic pneumoperitoneum, transanal total mesorectal excision (taTME) can better expose the surgical field of distal mesorectal space, and may have a prospect for the preservation of pelvic nerves and organ function. The transanal minimally invasive surgery (TAMIS) platform may decrease the injury of internal anal sphincter and protect anal function. Current data show that taTME procedure has similar results on postoperative anal function, urinary function and sexual function compared to transabdominal TME procedure. Read More

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[The crucial techniques and anatomic markers in transanal total mesorectal excision].

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Mar;22(3):220-223

Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.

Transanal total mesorectal excision (taTME) for rectal cancer is a hot spot in the field of colorectal surgery in recent years, because this technique has the advantages of clear distal margin, early separation of tumor leision, in the treatment of low rectal cancer. However, this technique is not popularized yet, and there are only a few colorectal surgeons who have enough experience. This article shares the experience of taTME in our hospital, including the details of purse string suture, spiral dissection of rectum, and the anatomic markers of anterior and posterior of rectum, conjoined longitudinal muscle and capillary of pelvic nerves locating in pelvic fascia. Read More

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March 2019
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[Transanal total mesorectal excision in laparoscopic surgery for lower rectal cancer: leading actor or supporting actor].

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Mar;22(3):215-219

Department of Gastrointestinal Surgery, Shanghai Minimal Invasive Surgery Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.

Transanal total mesorectal excision (taTME) is a hot topic currently in colorectal surgery. It has several advantages for lower rectal cancer, especially for male obese patients with narrow pelvis. But the indication of taTME which can really achieve the completeness of TME is limited. Read More

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[How to promote the clinical study of transanal total mesorectal excision in China].

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Mar;22(3):211-214

Department of General Surgery, Beijing Friendship Hospital,Capital Medical University, and National Clinical Research Center for Digestive Diseases, Beijing 100050, China,Email: edu.cn.

China has the largest group of patients with colorectal cancer in the world, but there are few international guidelines for the diagnosis and treatment of colorectal cancer from China, or evidence of high-level " evidence-based medicine" research in China. Transanal total mesorectal excision (taTME) is a new surgical procedure emerging in the field of colorectal surgery in recent years. taTME-related clinical research is almost simultaneously carried out in parallel with its clinical practice in the world. Read More

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[Establishment and expansion of transanal endoscopic surgery system].

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Mar;22(3):207-210

Department of Colorectal Surgery, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.

The surgical treatment of low rectal diseases has gradually changed from open radical operation to endoscopic minimally invasive operation. Transanal total mesorectal excision (taTME) combines endoscopic technique with transanal approach, and solves the problem of surgery exposure in lower rectal cancer. It has become an option for colorectal surgeons in lower rectal cancer. Read More

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Incidental diagnosis of very small rectal neuroendocrine neoplasms: when should endoscopic submucosal dissection be performed? A single ENETS centre experience.

Endocrine 2019 Mar 27. Epub 2019 Mar 27.

Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum-Università di Bologna, Bologna, Italy.

Purpose: The management of small (≤5 mm) rectal neuroendocrine neoplasms (r-NENs), incidentally removed during colonoscopy, still remains under debate.

Methods: All consecutive patients affected by r-NENs from January 2013 to December 2017 were studied. The inclusion criteria were: (1) patients having an incidental pathological diagnosis of very small (≤5 mm) polypoid r-NENs; (2) patients treated with a standard polypectomy as first-line therapy and (3) patients treated by endoscopic submucosal dissection (ESD) as salvage therapy. Read More

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http://dx.doi.org/10.1007/s12020-019-01907-yDOI Listing
March 2019
1 Read

Impact of primary colorectal Cancer location on the KRAS status and its prognostic value.

BMC Gastroenterol 2019 Mar 27;19(1):46. Epub 2019 Mar 27.

Department of Research, Affiliated Tumor Hospital of Guangxi Medical University, 71 Hedi Road, Nanning, 530021, China.

Background: Colorectal cancer (CRC) originating from the right-sided or left-sided colon is distinct clinicopathological entity. The KRAS status and its prognostic value in CRC remain controversial. This study aimed to investigate the association of KRAS status with clinicopathological features and prognostic value in CRC. Read More

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http://dx.doi.org/10.1186/s12876-019-0965-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437985PMC
March 2019
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Oncological outcome of peripartum colorectal carcinoma-a single-center experience.

Int J Colorectal Dis 2019 May 26;34(5):899-904. Epub 2019 Mar 26.

Division of Colon and Rectal Surgery, Assistant Professor of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Objectives: This study aimed to analyze disease presentation, management, and oncological outcomes of patients diagnosed with peripartum colorectal cancer (CRC).

Methods: Retrospective cohort study of all consecutive women of childbearing age (18-45 years) between 2002 and 2014 diagnosed with CRC adenocarcinoma at a tertiary academic institution. Patients who experienced pregnancy within 12 months of their diagnosis (peripartum period, group 1) were compared to the remaining patients of the cohort (group 2). Read More

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http://dx.doi.org/10.1007/s00384-019-03278-2DOI Listing
May 2019
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[A Case of Early-Onset Breast Cancer for Which the Operative Indication for Breast Conservation Was Based on BRCA Genetic Testing].

Gan To Kagaku Ryoho 2019 Mar;46(3):555-557

Breast Center, Kochi Medical School Hospital.

We report a case of a patient with early-onset breast cancer who decided to undergo adaptation for breast-conserving surgery based on the results of genetic testing. A 25-year-old woman became aware of a lump in her left breast and visited a nearby hospital, where she was diagnosed with breast cancer. She has no personal history. Read More

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March 2019
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[Long-Term Survival by Multidisciplinary Treatments in a Non-Curative Resected Case of Rectal Mucinous Carcinoma Occurring 20 Years after Surgery for Rectal Carcinoma].

Gan To Kagaku Ryoho 2019 Mar;46(3):487-489

Dept. of Surgery, Fujisaki Hospital.

We reported the long-term survival ofa patient who underwent multidisciplinary treatments for non-curative resected rectal mucinous carcinoma that occurred 20 years after rectal carcinoma surgery. A 69-year-old man who had undergone a lower anterior resection for rectal cancer diagnosed approximately 20 years prior was referred to our hospital with a diagnosis ofrectal cancer. The tumor was detected near the rectal anastomosis ofthe previous surgery. Read More

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March 2019
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Hyaluronic gel injection into the vesicovaginal septum for high-dose-rate brachytherapy of uterine cervical cancer: an effective approach for bladder dose reduction.

J Contemp Brachytherapy 2019 Feb 29;11(1):1-7. Epub 2019 Jan 29.

Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.

Purpose: The purpose of this study was to report our initial experience of hyaluronic acid gel injection (HGI) in the vesicovaginal septum (VVS) for bladder dose reduction in brachytherapy (BT) for uterine cervical carcinoma.

Material And Methods: Between September 2016 and May 2018, 15 uterine cervical cancer patients received HGI in the VVS as a part of their definitive radiotherapy (RT) treatment consisting of external beam radiation therapy (EBRT) with additional BT. Of those, 9 patients received BT both with and without HGI, and remaining 6 patients were excluded because these 6 patients received HGI in the VVS for all BT fractions. Read More

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http://dx.doi.org/10.5114/jcb.2019.82612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431109PMC
February 2019
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Lymph node ratio, an independent prognostic factor for patients with stage II-III rectal carcinoma.

Pathol Res Pract 2019 Mar 7. Epub 2019 Mar 7.

Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology, Targu Mures, Romania.

Background: Identification of the proper surgical method and the most reliable prognostic parameters of rectal carcinomas is a challenging issue. The aim of this paper was to determine the possible prognostic role of the number of harvested lymph nodes versus lymph node ratio (LNR) in patients with rectal carcinomas, and the proper value of LNR that can be used as prognostic parameter.

Materials And Methods: A retrospective study was performed in 186 consecutive patients with rectal carcinomas that underwent surgical resection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03440338183168
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http://dx.doi.org/10.1016/j.prp.2019.03.013DOI Listing
March 2019
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Long-term control with chemoradiation of initially metastatic mixed adenoneuroendocrine carcinoma of the rectum: a case report.

J Med Case Rep 2019 Mar 23;13(1):82. Epub 2019 Mar 23.

Department of Radiation Oncology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Universitätsstraße 27, 91054, Erlangen, Germany.

Background: Mixed adenoneuroendocrine carcinomas are highly malignant tumors with both adenocarcinomatous and neuroendocrine components. They can originate in any organ but are more common in the rectum. Due to their rarity, current treatment recommendations for mixed adenoneuroendocrine carcinoma are based on limited data and follow general guidelines for the management of adenocarcinomas and neuroendocrine neoplasms. Read More

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http://dx.doi.org/10.1186/s13256-019-1995-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431024PMC
March 2019
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Phospho-ERK levels as predictors for chemotherapy of rectal carcinoma.

Oncotarget 2019 Mar 1;10(18):1745-1755. Epub 2019 Mar 1.

Department of Pathology, Copenhagen University Hospital Hvidovre, DK-2650 Hvidovre, Denmark.

Treatment of rectal cancer has been vastly improved by advances in surgery and radiochemotherapy but remains an important cause of morbidity and mortality worldwide. A particular problem is the lack of predictive markers that can help to individualize treatment. The growth- and apoptosis-regulating signaling molecules ERK 1 and 2 are important to cancer growth and progression. Read More

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http://www.oncotarget.com/fulltext/26741
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http://dx.doi.org/10.18632/oncotarget.26741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422203PMC
March 2019
5 Reads

Primary squamous cell carcinoma of the seminal vesicle: A case report and review of the literature.

Medicine (Baltimore) 2019 Mar;98(12):e14788

Department of Urology, The Second Hospital of Anhui Medical University, Hefei, Anhui Province, China.

Rationale: Primary squamous cell carcinoma (SCC) of the seminal vesicle is extremely rare, and the clinical characteristics of this kind of malignancy are still unclear.

Patient Concerns: A 62-year-old male patient presented with complaints of sensation of rectal tenesmus and dysuria.

Diagnosis: Ultrasonography suggested a hypoechoic mass behind the bladder, meanwhile, computerized tomography (CT) and magnetic resonance imaging (MRI) revealed a 40 mm × 45 mm × 48 mm mixed solid/cystic tumorous lesion in the right seminal vesicle. Read More

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http://dx.doi.org/10.1097/MD.0000000000014788DOI Listing
March 2019
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Association between KRAS G13D mutations and anastomotic recurrence in colorectal cancer: Two case reports.

Medicine (Baltimore) 2019 Mar;98(12):e14781

Rationale: The prevalence of anastomotic recurrence (AR) in colorectal cancer (CRC) after resection of the primary tumor (PT) is 5% to 14%. However, no association has been observed between specific somatic genetic alterations and AR. Such associations may shed light on the mechanism of AR. Read More

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http://dx.doi.org/10.1097/MD.0000000000014781DOI Listing
March 2019
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Unexpected destination! Rectal carcinoma metastasis to breast.

J Surg Case Rep 2019 Mar 14;2019(3):rjz036. Epub 2019 Mar 14.

Department of Surgery, Letterkenny University Hospital Letterkenny, County Donegal, Ireland.

Rectal cancer metastasis to the breast is rare with around 19 cases reported in literature. It signifies diffuse disseminated disease or highly aggressive tumour, such that surgical intervention other than palliation has a limited role. We report a case of a 43-year-old with the above presentation. Read More

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http://dx.doi.org/10.1093/jscr/rjz036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416825PMC
March 2019
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Structured training pathway and proctoring; multicenter results of the implementation of transanal total mesorectal excision (TaTME) in the Netherlands.

Surg Endosc 2019 Mar 19. Epub 2019 Mar 19.

Department of Surgery, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Background: Transanal total mesorectal excision (TaTME) is a new complex technique with potential to improve the quality of surgical mesorectal excision for patients with mid and low rectal cancer. The procedure is technically challenging and has shown to be associated with a relative long learning curve which might hamper widespread adoption. Therefore, a national structured training pathway for TaTME has been set up in the Netherlands to allow safe implementation. Read More

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http://dx.doi.org/10.1007/s00464-019-06750-wDOI Listing
March 2019
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