71,651 results match your criteria Rectal Carcinoma

Validation of a scoring system to predict bladder dysfunction after laparoscopic rectal cancer surgery.

Langenbecks Arch Surg 2022 Jun 24. Epub 2022 Jun 24.

Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul, 03181, Republic of Korea.

Purpose: A recent trend in  urinary catheter management in patients who underwent laparoscopic rectal cancer surgery is early removal. However, some patients develop bladder dysfunction and require urinary re-catheterization. In 2016, a scoring system to predict bladder dysfunction after laparoscopic rectal cancer surgery was developed in our institution. Read More

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Colorectal Carcinoma in the Background of Pelvic Inflammatory Disease.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221106755

Texas Tech University Health Sciences Center El Paso, TX, USA.

Colorectal carcinoma (CRC) is a common malignancy with steadily declining incidence rates and mortality, secondary to improved screening and lifestyle changes (eg, decreased smoking rates). The association between pelvic inflammatory disease (PID) and CRC has been unclear in the past. However, multiple studies showed a positive association between PID and underlying malignancy (gynecologic and pelvic primarily). Read More

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[Two Cases of Robot-Assisted Total Pelvic Exenteration and Intracorporeal Ileal Conduit forLocally Advanced Rectal Cancer].

Hinyokika Kiyo 2022 May;68(5):155-159

The Department of Digestive Surgery and Transplantation, Tokushima University Graduate School of Biomedical Sciences.

We describe two cases of locally advanced rectal cancer (LARC) treated with robot-assisted total pelvic exenteration (Ra-TPE) and intracorporeal ileal conduit (ICIC). The first case was in a 71-year-old man with LARC (RbP, T4bN2bM0, cStage IIIc). He was started on bevacizumab+S-1/oxaliplatin therapy in July 2019. Read More

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Antiangiogenic Drug-Induced Proteinuria as a Prognostic Factor in Metastatic Colorectal Cancer.

Curr Oncol 2022 May 31;29(6):3996-4011. Epub 2022 May 31.

Immunology Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.

Treatment with bevacizumab is known to cause adverse events such as proteinuria and hypertension, amongst others. However, while bevacizumab-induced hypertension has been linked to increased overall survival (OS), data on proteinuria are controversial. We performed a retrospective analysis to observe the influence of adverse events developed during treatment with bevacizumab and chemotherapy on the OS in patients with metastatic colorectal cancer (mCRC). Read More

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Long-term outcomes after extra-levator versus conventional abdominoperineal excision for low rectal cancer.

BMC Surg 2022 Jun 22;22(1):242. Epub 2022 Jun 22.

Department of General Surgery, Beijing Chaoyang Hosptial, Capital Medical University, No. 8 Gongtinan Lu, Chaoyang District, Beijing, People's Republic of China.

Purpose: Extralevator (ELAPE) and abdominoperineal excision (APE) are two major surgical approaches for low rectal cancer patients. Although excellent short-term efficacy is achieved in patients undergoing ELAPE, the long-term benefits have not been established. In this study we evaluated the safety, pathological and survival outcomes in rectal cancer patients who underwent ELAPE and APE. Read More

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Effects of Preoperative Radiotherapy on Long-Term Bowel Function in Patients With Rectal Cancer Treated With Anterior Resection: A Systematic Review and Meta-analysis.

Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221105156

Department of Gastrointestinal Surgery, Department of General Surgery, 89346Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.

Anterior resection is a common surgical approach used in rectal cancer surgery; however, this procedure is known to cause bowel injury and dysfunction. Neoadjuvant therapy is widely used in patients with locally advanced rectal cancer. In this study, we determined the effect of preoperative radiotherapy on long-term bowel function in patients who underwent anterior resection for treatment of rectal cancer. Read More

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Effect of intrafraction adaptation on PTV margins for MRI guided online adaptive radiotherapy for rectal cancer.

Radiat Oncol 2022 Jun 21;17(1):110. Epub 2022 Jun 21.

Department of Radiation Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

Purpose: To determine PTV margins for intrafraction motion in MRI-guided online adaptive radiotherapy for rectal cancer and the potential benefit of performing a 2nd adaptation prior to irradiation.

Methods: Thirty patients with rectal cancer received radiotherapy on a 1.5 T MR-Linac. Read More

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State-of-the-art surgery for Crohn's disease: Part II-colonic Crohn's disease and associated neoplasms.

Langenbecks Arch Surg 2022 Jun 22. Epub 2022 Jun 22.

Hiram C. Polk, Jr MD Department of Surgery, Price Institute of Surgical Research, University of Louisville, Louisville, KY, 40292, USA.

Despite advances in medical therapy, surgery continues to play a vital role in the management of Crohn's disease and its complications. Continuing from Part I of this series (small intestine/ileal disease), we focus next on colonic Crohn's disease and associated neoplasms. We will first review the surgical management of medical-refractory Crohn's colitis and its complications and then examine cancer risk, surveillance, and surgical management of Crohn's-associated colorectal dysplasia and malignancy. Read More

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Native T1 mapping for differentiating the histopathologic type, grade, and stage of rectal adenocarcinoma: a pilot study.

Cancer Imaging 2022 Jun 17;22(1):30. Epub 2022 Jun 17.

MR Collaboration, Siemens Healthcare Ltd, Beijing, 100000, China.

Background: Previous studies have indicated that T1 relaxation time could be utilized for the analysis of tissue characteristics. T1 mapping technology has been gradually used on research of body tumor. In this study, the application of native T1 relaxation time for differentiating the histopathologic type, grade, and stage of rectal adenocarcinoma was investigated. Read More

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Analysis of MRI and CT-based radiomics features for personalized treatment in locally advanced rectal cancer and external validation of published radiomics models.

Sci Rep 2022 Jun 17;12(1):10192. Epub 2022 Jun 17.

OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.

Radiomics analyses commonly apply imaging features of different complexity for the prediction of the endpoint of interest. However, the prognostic value of each feature class is generally unclear. Furthermore, many radiomics models lack independent external validation that is decisive for their clinical application. Read More

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Perianal basal cell carcinoma managed with wide excision and random flap reconstruction.

BMJ Case Rep 2022 Jun 20;15(6). Epub 2022 Jun 20.

Department of Surgery, University of the Philippines-Philippine General Hospital, Manila, Metro Manila, Philippines.

Basal cell carcinoma (BCC) is a common skin malignancy and usually occurs in sun-exposed areas like the head and neck. Occurrence in the perianal area is rare, accounting for only 0.08% of all BCC, and 0. Read More

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[The primary surgical therapy of a synchronous sigmoid, rectal and vulvar cancer].

Magy Onkol 2022 Jun 27;66(2):153-156. Epub 2021 Apr 27.

Általános Ér- és Plasztikai Sebészeti Osztály, Markusovszky Egyetemi Oktatókórház, Szombathely, Hungary.

Malignant tumors were the leading cause of death in Hungary between 1990 and 2018 according to the central statistical office (www.ksh.hu). Read More

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Radiodermatitis: severity, predictive factors and discontinuation of radiotherapy in patients with anal and rectal cancer.

Rev Esc Enferm USP 2022 15;56:e20210378. Epub 2022 Jun 15.

Instituto Nacional de Câncer José Alencar Gomes da Silva, Programa de Residência Multiprofissional em Oncologia, Rio de Janeiro, RJ, Brazil.

Objective: to determine the prevalence of radiodermatitis, severity grades and predictive factors of its occurrence in patients with anal and rectal cancer followed up by the nursing consultation, and to analyze the association of severity grades of radiodermatitis with temporary radiotherapy interruption.

Method: a quantitative, cross-sectional and retrospective study, carried out with 112 medical records of patients with anal and rectal cancer undergoing curative radiotherapy followed up in the nursing consultation. Data were collected using a form and analyzed using analytical and inferential statistics. Read More

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Stage IV anal canal squamous cell carcinoma with long-term survival: a case report.

Surg Case Rep 2022 Jun 20;8(1):119. Epub 2022 Jun 20.

First Department of Surgery, University of Fukui, 23-3 Matsuoka Shimoaizuki Eiheiji-cho, Yoshidagun, Fukui, 910-1193, Japan.

Background: Currently, no established standard treatment exists for metastatic anal squamous cell carcinoma. We report a case of complete response in a patient with stage IV anal squamous cell carcinoma after undergoing multidisciplinary treatment.

Case Presentation: A 62-year-old woman visited a nearby doctor with a chief concern of severe pain associated with a firm mass in the anus. Read More

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Application of Imaging Indicators Based on F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Colorectal Peritoneal Carcinomatosis.

Front Oncol 2022 26;12:888680. Epub 2022 May 26.

Department of General Surgery, Affiliated Hospital of Nantong University, Jiangsu, China.

Objective: The imaging features of peritoneal carcinomatosis (PC) with different locations and pathological types of colorectal cancer (CRC) on F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) were analyzed and discussed.

Methods: The PET/CT data of 132 patients with colorectal peritoneal carcinomatosis (CRPC) who met the inclusion and exclusion criteria between May 30, 2016, and December 31, 2019, were collected and analyzed. Observations included the location and pathological type of CRC, the peritoneal cancer index (PCI), standardized uptake maximum value (SUV), and retention index (RI) of the CRPC. Read More

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CT Colonography and Colorectal Carcinoma: Current Trends and Emerging Developments.

Cureus 2022 May 11;14(5):e24916. Epub 2022 May 11.

Internal Medicine, Jagadguru Jayadeva Murugarajendra Medical College, Davangere, IND.

Colorectal carcinoma is the third most malignant and second leading cause of death from cancer. The cruelty of this entity is that it takes decades to be symptomatic and is known to be detected late in its timeline by a screening technique. The fatality of this carcinoma only means heightened importance of screening guidelines to be laid down and strict follow-ups by the healthcare providers. Read More

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The Relationship Between Plant-Based Diet and Risk of Digestive System Cancers: A Meta-Analysis Based on 3,059,009 Subjects.

Front Public Health 2022 3;10:892153. Epub 2022 Jun 3.

Department of Gastroenterology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.

Background And Objectives: Diets containing red or processed meat are associated with a growing risk of digestive system cancers. Whether a plant-based diet is protective against cancer needs a high level of statistical evidence.

Methods: We performed a meta-analysis of five English databases, including PubMed, Medline, Embase, Web of Science databases, and Scopus, on October 24, 2021 to identify published papers. Read More

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Current status of neoadjuvant therapy for locally advanced rectal cancer in Wuhan Union Hospital Cancer Center.

Radiat Oncol 2022 Jun 20;17(1):109. Epub 2022 Jun 20.

Cancer Center, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: To analyze and explore the evolution and short-term efficacy of neoadjuvant therapy for patients with mid and low LARC in Wuhan Union Hospital Cancer Center.

Methods: Patients diagnosed with rectal cancer from January 2015 to December 2021 were collected. The treatment patterns, short-term efficacy and treatment-related adverse events (AEs) of mid and low LARC patients who received neoadjuvant therapy were analyzed. Read More

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ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.

Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347

Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, Ohio. Electronic address:

Purpose: Previous anal cancer guidelines delineate target volumes similarly for all patients with squamous cell carcinoma of the anal canal and/or perianal skin (SCCA), regardless of disease stage. The purpose of this guideline is to provide customized radiation treatment recommendations for early stage (T1-2 N0 M0) anal cancer treated with intensity modulated and image guided radiation therapy (RT).

Methods And Materials: A contouring atlas and radiation treatment recommendations for the ongoing, randomized phase II trial of deintensified chemoradiation for early stage SCCA (EA2182) was created by an expert panel of radiation oncologists. Read More

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Colorectal cancer screening with fecal immunochemical testing: a community-based, cross-sectional study in average-risk individuals in Nigeria.

Lancet Glob Health 2022 Jul;10(7):e1012-e1022

African Research Group for Oncology, Osun, Nigeria; Department of Surgery, and Global Cancer Disparities Initiative, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

Background: The estimated incidence of colorectal cancer is rising in Nigeria, where most patients present with advanced disease. Earlier detection of colorectal cancer is a goal of the Nigerian National Cancer Control Plan, but the utility of fecal-based screening is unclear. This study aimed to assess the fecal immunochemical test as a colorectal cancer screening modality in average-risk individualS in Nigeria. Read More

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Perianal Basal Cell Carcinoma: 35-Year Experience.

Dis Colon Rectum 2021 Dec 27. Epub 2021 Dec 27.

Division of Colon and Rectal Surgery, Mayo Clinic Rochester, Minneapolis.

Background: Basal cell carcinoma of the perianal region is a rare anorectal disease. This condition is not related to exposure to ultra-violet radiation. Due to the low prevalence and poor detection, there is a paucity of data relating to this condition in literature. Read More

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December 2021

Artificial intelligence-based technology for semi-automated segmentation of rectal cancer using high-resolution MRI.

PLoS One 2022 17;17(6):e0269931. Epub 2022 Jun 17.

Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan.

Aim: Although MRI has a substantial role in directing treatment decisions for locally advanced rectal cancer, precise interpretation of the findings is not necessarily available at every institution. In this study, we aimed to develop artificial intelligence-based software for the segmentation of rectal cancer that can be used for staging to optimize treatment strategy and for preoperative surgical simulation.

Method: Images from a total of 201 patients who underwent preoperative MRI were analyzed for training data. Read More

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Knowledge, attitudes, and practices of active surveillance in prostate cancer among urologists: a real-life survey from Brazil.

BMC Urol 2022 Jun 15;22(1):86. Epub 2022 Jun 15.

Hospital Israelita Albert Einstein, Rua Iguatemi, 192, cj. 43, São Paulo, SP, CEP: 04530-050, Brazil.

Background: Active surveillance (AS) is the preferred treatment for patients with very low-and low-risk prostate cancer (PCa), but it is underperformed worldwide. This study aimed to report knowledge, attitudes, and practices (KAP) of AS for PCa among urologists in Brazil.

Methods: This cross-sectional study used a questionnaire with 50 questions divided into participant characteristics, knowledge regarding inclusion criteria for AS, follow-up, intervention triggers, acceptance, and practice for an index patient. Read More

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Designing and evaluating a patient decision aid for patients with locally advanced or locally recurrent rectal cancer: a national multicentre mixed methods study protocol.

BMJ Open 2022 Jun 15;12(6):e056984. Epub 2022 Jun 15.

Manchester University NHS Foundation Trust, Manchester, Greater Manchester, UK.

Introduction: Approximately 5%-10% of new rectal cancers are locally advanced (locally advanced rectal cancer (LARC)) at presentation with 4%-8% recurring (locally recurrent rectal cancer (LRRC)) after initial treatment. Patients with potentially curable disease have to consider many trade-offs when considering major exenterative surgery. There are no decision tools for these patients and current resources have found to not meet minimum international standards. Read More

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Circulating tumour cell gene expression and chemosensitivity analyses: predictive accuracy for response to multidisciplinary treatment of patients with unresectable refractory recurrent rectal cancer or unresectable refractory colorectal cancer liver metastases.

BMC Cancer 2022 Jun 16;22(1):660. Epub 2022 Jun 16.

Department of Applied Clinical and Biotechnological Sciences, University of L'Aquila, 67100, L'Aquila, Italy.

Background: Patients with unresectable recurrent rectal cancer (RRC) or colorectal cancer (CRC) with liver metastases, refractory to at least two lines of traditional systemic therapy, may receive third line intraarterial chemotherapy (IC) and targeted therapy (TT) using drugs selected by chemosensitivity and tumor gene expression analyses of liquid biopsy-derived circulating tumor cells (CTCs).

Methods: In this retrospective study, 36 patients with refractory unresectable RRC or refractory unresectable CRC liver metastases were submitted for IC and TT with agents selected by precision oncotherapy chemosensitivity assays performed on liquid biopsy-derived CTCs, transiently cultured in vitro, and by tumor gene expression in the same CTC population, as a ratio to tumor gene expression in peripheral mononuclear blood cells (PMBCs) from the same individual. The endpoint was to evaluate the predictive accuracy of a specific liquid biopsy precision oncotherapy CTC purification and in vitro culture methodology for a positive RECIST 1. Read More

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Local recurrence of robot-assisted total mesorectal excision: a multicentre cohort study evaluating the initial cases.

Int J Colorectal Dis 2022 Jun 16. Epub 2022 Jun 16.

Department of Surgery, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.

Purpose: Evidence regarding local recurrence rates in the initial cases after implementation of robot-assisted total mesorectal excision is limited. This study aims to describe local recurrence rates in four large Dutch centres during their initial cases.

Methods: Four large Dutch centres started with the implementation of robot-assisted total mesorectal excision in respectively 2011, 2012, 2015, and 2016. Read More

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Management and outcome of colorectal cancer in a resource-limited setting: Ahmadu Bello university teaching hospital, Zaria, Nigeria.

Niger J Clin Pract 2022 Jun;25(6):923-930

Department of Oncology, Federal Medical Centre, Jabi, Abuja, Nigeria.

Background: Colorectal cancer (CRC) is one of the most common malignancies seen in the Western World. It is increasing in developing countries due to adaptation of the western lifestyle with an incidence of 6% in Nigeria. Treatment options are dependent on the stage of disease at presentation, the performance status of the patient, and increasingly the molecular makeup of the tumor. Read More

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The Preoperative Diagnostic Performance of Multi-Parametric Quantitative Assessment in Rectal Carcinoma: A Preliminary Study Using Synthetic Magnetic Resonance Imaging.

Front Oncol 2022 25;12:682003. Epub 2022 May 25.

Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China.

Objective: Synthetic MRI (SyMRI) can reconstruct different contrast-weighted images(T1, T2, PD) and has shorter scan time, easier post-processing and better reproducibility. Some studies have shown splendid correlation with conventional mapping techniques and no degradation in the quality of syMRI images compared with conventional MRI. It is crucial to select an individualized treatment plan based on the preoperative images of rectal carcinoma (RC). Read More

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[Endoscopic Resection for GEP-NET].

Zentralbl Chir 2022 Jun 15;147(3):256-263. Epub 2022 Jun 15.

I. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.

Neuroendocrine tumours (NET) are rare tumours of the gastrointestinal tract. Many of these are diagnosed incidentally during routine upper and lower GI endoscopy. Complete surgical resection is the treatment of choice for localised tumours. Read More

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