Search Our Scientific Publications & Authors

Int J Surg 2019 Feb 19. Epub 2019 Feb 19.

Department of Surgery, Soba University Hospital, Khartoum, Sudan. Electronic address:

Int Wound J 2019 Mar;16 Suppl 1:71-75

Department of Clinical Nursing, University of Ulsan, Seoul, South Korea.

A research survey research was conducted to identify factors affecting changes in bowel habits of rectal cancer patients undergoing sphincter-saving surgery and to provide basic information useful in nursing interventions supporting treatment for rectal cancer patients. The subjects were rectal cancer patients who had undergone sphincter-saving surgery over 2 years ago. The final analysis included 107 patients who had made outpatient visits to the colorectal surgery from 12th to 31st May, 2014. Read More

Neoplasma 2019 Feb 17;2019. Epub 2019 Feb 17.

3rd Surgical Clinic, Faculty of Medicine, Comenius University, Bratislava, Slovakia.

In past decades, both prognosis and therapy of rectal cancer patients showed significant improvement, on the other hand, the incidence of rectal carcinoma continues to have a rising tendency. According to current UICC classification, patients in stage II rectal cancer or higher are indicated for neoadjuvant chemoradiotherapy (nCRT). Magnetic resonance imaging (MRI) is currently the most common diagnostic method used for preoperative staging of rectal cancer. Read More

Br J Cancer 2019 Feb 22. Epub 2019 Feb 22.

Research Unit of General Practice, Department of Public Health, University of Southern Denmark, J. B. Winsløws Vej 9A, 5000, Odense C, Denmark.

Background: Alarm symptoms are used in many cancer referral guidelines. The objectives were to determine the 1-year predictive values (PVs) of colorectal cancer (CRC) alarm symptoms in the general population and to describe the proportion of alarm symptoms reported prior to diagnosis.

Methods: A nationwide prospective cohort of 69,060 individuals ≥40 years randomly selected from the Danish population was invited to complete a survey regarding symptoms and healthcare-seeking in 2012. Read More

Clin Colorectal Cancer 2019 Jan 29. Epub 2019 Jan 29.

Head Surgery Unit, Clinical Sciences Department, College of Medicine University of Sharjah, Sharjah, United Arab Emirates. Electronic address:

Surgery remains the mainstay of curative treatment for colorectal cancer (CRC). Despite curative surgery, some patients experience cancer recurrence. However, the pattern, stage, and time of recurrent disease (RD) remain unknown. Read More

Cancer Med 2019 Feb 21. Epub 2019 Feb 21.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Tumor deposit (TD) was associated with poor survival in colorectal cancer. However, its prognostic and staging value in locally advanced rectal cancer (LARC) patients following neoadjuvant chemoradiotherapy (neo-CRT) is controversial. Four hundred and ninety-five LARC patients following neo-CRT and surgery were retrospectively analyzed. Read More

Updates Surg 2019 Feb 21. Epub 2019 Feb 21.

Department of Colorectal Surgery, The Royal Marsden Hospital, London, UK.

The objective is to investigate preoperative body mass index (BMI) in patients receiving beyond total mesorectal excision (bTME) surgery. The primary end point is length of postoperative stay. Secondary end points are length of intensive care stay, postoperative morbidity and overall survival. Read More

Int J Colorectal Dis 2019 Feb 21. Epub 2019 Feb 21.

Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Purpose: Low anterior resection with coloanal anastomosis (CAA) for low rectal cancer is a technically difficult operation with limited data available on oncologic outcomes. We aim to investigate overall survival and operative oncologic outcomes in patients who underwent CAA compared to abdominoperineal resection (APR).

Methods: The National Cancer Database (2004-2013) was used to identify patients with non-metastatic rectal adenocarcinoma who underwent CAA or APR. Read More

Ultrasound Q 2019 Feb 16. Epub 2019 Feb 16.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University.

The aim of this study was to compare the effectiveness of physical examination, transvaginal sonography, magnetic resonance imaging, and rectal endoscopic sonography for the identification of rectovaginal endometriosis and potential rectal infiltration. Women with suspected rectovaginal endometriosis underwent physical examination, transvaginal sonography, magnetic resonance imaging, and rectal endoscopic sonography. Evaluation was performed for the presence of rectovaginal endometriotic foci and rectal infiltration. Read More

Acta Oncol 2019 Feb 21:1-5. Epub 2019 Feb 21.

a Department of Colorectal Surgery , Oxford University Hospitals , Oxford , UK.

Background: Local excision is now accepted as a standard treatment option for certain patients with early rectal cancer. However, there is a higher risk of local recurrence than after radical surgery with total mesorectal excision. Adjuvant radiotherapy after local excision may reduce this excess risk, and yet retain the benefits of local excision, with rectal preservation. Read More

Tech Coloproctol 2019 Feb 20. Epub 2019 Feb 20.

Department of Gastrointestinal Surgery, Hospital Clinic, Villarroel, 170, 08036, Barcelona, Spain.

Abdom Radiol (NY) 2019 Feb 20. Epub 2019 Feb 20.

University of British Columbia, Vancouver, BC, Canada.

Cureus 2018 Dec 8;10(12):e3704. Epub 2018 Dec 8.

Radiation Oncology, London Regional Cancer Program, Western University, London, CAN.

Palmar-plantar erythrodysesthesia (PPE) is a common dermatologic adverse reaction secondary to capecitabine use, but the skin toxicity rarely involves the genitals. We describe a case of PPE with scrotal and penile involvement secondary to capecitabine chemotherapy concurrent with radiotherapy. The patient presented with pain and erythema involving the penis and scrotum during the fifth week of neoadjuvant chemoradiotherapy with capecitabine for T3c N2b M0 low rectal adenocarcinoma. Read More

J Gastrointest Oncol 2019 Feb;10(1):42-47

Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore.

Background: Obtaining 12 lymph nodes following resection for rectal cancer is an important prognostic marker. However, patients who have received neoadjuvant therapy are known to have a lower lymph node yield. We conducted this study to determine the clinical significance of evaluating <12 versus ≥12 lymph nodes in individuals who underwent surgery following neoadjuvant therapy for rectal cancer. Read More

J Gastrointest Oncol 2019 Feb;10(1):19-29

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India.

Background: The available evidence in locally advanced rectal cancer (LARC) suggests a low prevalence of deficient mismatch repair (dMMR) protein status, approximating 1-3%.

Methods: Patients with LARC who were offered long course chemoradiation (LCRT), as per institution protocol during the period of 1st January 2014 to 31st December 2015 at Tata Memorial Hospital (TMH) in Mumbai were evaluated for outcomes and assessment of MMR status.

Results: A total of 419 patients were evaluated for LARC in TMH, of whom 354 were treated with LCRT. Read More

Sci Rep 2019 Feb 20;9(1):2404. Epub 2019 Feb 20.

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

Rectal neuroendocrine tumors (NETs) are often found as small lesions, which can be treated by endoscopic resection. However, high risk cases with lymph node (LN) metastasis are indication of radical surgery. Furthermore, rectal NETs are often associated with late recurrences and/or multiple cancer development. Read More

Hum Genomics 2019 Feb 20;13(1):12. Epub 2019 Feb 20.

Division of Cancer Biology, University of Puerto Rico Comprehensive Cancer Center, PMB 711 Ave. De Diego 89 Ste. 105, San Juan, PR, 00927-6346, USA.

Background: Colorectal cancer (CRC) is the first cause of cancer deaths among Puerto Ricans. The incidence and mortality of CRC in Puerto Rico continue to be on the rise. The burden of CRC in Puerto Rico is higher than among US Hispanics and is second only to African Americans, thus supporting the importance of studying this CRC health disparity. Read More

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):428-431

Department of Urology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China.

To assess the complications of transperineal template-guided prostate mapping biopsy (TTMB). Between May 2017 and March 2018, 142 consecutive patients with prior negative transrectal biopsy results and persistently elevated prostate-specific antigen (PSA) were divided into the observation group and the control group randomly. The observation group underwent TTMB and the control group underwent transperineal template-guided prostate saturation biopsy (TTSB). Read More

JAMA Surg 2019 Feb 20. Epub 2019 Feb 20.

Center for Healthcare Outcomes and Policy, University of Michigan, Ann Arbor.

Importance: The American College of Surgeons National Accreditation Program for Rectal Cancer (NAPRC) promotes multidisciplinary care to improve oncologic outcomes in rectal cancer. However, accreditation requirements may be difficult to achieve for the lowest-performing institutions. Thus, it is unknown whether the NAPRC will motivate care improvement in these settings or widen disparities. Read More

Tech Coloproctol 2019 Feb 19. Epub 2019 Feb 19.

Department of Colorectal Surgery, Good Hope Hospital, Heart of England NHS Foundation Trust, Rectory Road, Sutton Coldfield, Birmingham, B75 7RR, UK.

Background: This study aimed to determine if the nature of circumferential resection margin (CRM) involvement, either by tumour or lymph nodes, had an impact upon local recurrence and survival in rectal cancer.

Methods: A retrospective analysis of a prospectively collected database was performed. Consecutive patients with stage I-III rectal cancer having curative surgery were included. Read More

Exp Ther Med 2019 Mar 20;17(3):1517-1522. Epub 2018 Dec 20.

Department of Tumor Radiotherapy, Laigang Hospital Affiliated to Taishan Medical University, Laiwu, Shandong 271100, P.R. China.

Efficacy of the combination of oxaliplatin, 5-fluorouracil and radiotherapy on rectal cancer in elderly patients was investigated. Seventy-three elderly patients with rectal cancer confirmed by histopathological examination were randomly divided into 3 groups: oxaliplatin group (25 cases): intravenous infusion of oxaliplatin; fluorouracil group (24 cases): intravenous infusion of fluorouracil; combination group (24 cases), intravenous infusion of oxaliplatin and fluorouracil. All patients were treated with radiotherapy, and efficacy and safety were evaluated after 2 courses of treatment. Read More

Sci Rep 2019 Feb 19;9(1):2316. Epub 2019 Feb 19.

Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.

If anastomotic site leakage is expected after laparoscopic low anterior resection (LAR), de-functioning ileostomy is required. However, there is controversy about the consequence of stoma formation via the specimen extraction site (SES). Therefore, we aimed to investigate stoma-related complication according to stoma formation via the SES. Read More

Technol Cancer Res Treat 2019 Jan;18:1533033819831962

1 McGill University, Jewish General Hospital, Montreal, Quebec, Canada.

Purpose:: In this prospective phase II study, we investigated whether cone beam computed tomography scan was a superior method of image-guided radiotherapy relative to 2D orthogonal kilovoltage images in the post-radical prostatectomy setting.

Methods:: A total of 419 treatment fractions were included in this analysis. The shifts required to align the patient for each treatment were performed using 3D matching between cone beam computed tomography scans and the corresponding computed tomography images used for planning. Read More

Ann Glob Health 2018 Nov 5;84(4):679-682. Epub 2018 Nov 5.

Department of Radiation Oncology, University of Florida, US.

Background: The purpose of this study is to detail the implementation of HDR brachytherapy at the only radiotherapy center in Nicaragua.

Methods: Patients are treated with external-beam radiotherapy to 46-50Gy at 2Gy/fraction to the pelvis. A gynecologic examination is performed weekly. Read More

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):903-905

Department of Radiation Oncology, Azienda Sanitaria Universitaria Integrata UD, Udine, Italy.

Tech Coloproctol 2019 Feb 16. Epub 2019 Feb 16.

Division of Cancer Surgery, Victorian Comprehensive Cancer Centre, Melbourne, Australia.

Surg Today 2019 Feb 18. Epub 2019 Feb 18.

Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Guo Xue Xiang No. 37, Chengdu, 610041, China.

Purposes: This study aimed to explore the effect of increased body mass index (BMI) values (overweight: BMI ≥ 25-30 kg/m; obese: BMI ≥ 30 kg/m) on surgical outcomes after radical resection for low rectal cancer (LRC).

Methods: Patients with LRC who underwent radical surgery from January 2009 to December 2013 were included. The patients were divided into three groups according to their BMI values (control group: BMI < 25 kg/m; overweight group: BMI 25 to < 30 kg/m; obese group: BMI ≥ 30 kg/m). Read More

Surg Case Rep 2019 Feb 18;5(1):25. Epub 2019 Feb 18.

Department of Surgery, Osaka Rosai Hospital, 1179-3 Nagasonecho, Kita-ku, Sakai, 591-8025, Japan.

Background: A case of a short circuit (Retzius shunt) from the inferior mesenteric vein (IMV) to the inferior vena cava (IVC) without accompanying portal hypertension due to liver cirrhosis is rare.

Case Presentation: An 83-year-old woman who was followed after surgery for thyroid and breast cancer was incidentally found to have rectal cancer on computed tomography (CT). Preoperative three-dimensional CT showed a venous malformation forming a short circuit (Retzius shunt) from the IMV to the IVC. Read More

Int J Colorectal Dis 2019 Feb 18. Epub 2019 Feb 18.

Klinik für Allgemein-, Viszeral-, Thoraxchirurgie und Adipositasmedizin, Caritas Krankenhaus St. Josef Regensburg, Landshuter Str. 65, 93053, Regensburg, Germany.

Introduction: Rectal cancer is a frequently diagnosed tumor worldwide. Various studies have shown the noninferiority or even slight superiority of laparoscopic resection. However, there is no clear recommendation on whether age should influence the choice of surgical approach. Read More

Urol Oncol 2019 Feb 15. Epub 2019 Feb 15.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada; Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Purpose: Prostate cancer (CaP) patients with low-grade tumors are enrolled in active surveillance (AS) programs and monitored with digital rectal exams (DREs), prostate-specific antigen (PSA) tests, and periodic invasive biopsies. Patients are "reclassified" with higher-risk disease if they show signs of disease progression. However, AS patients who will reclassify cannot be easily identified upfront and suffer morbidities associated with biopsy. Read More

Am J Surg 2019 Mar;217(3):435-436

Br J Surg 2019 Feb 18. Epub 2019 Feb 18.

Department of Molecular Medicine and Surgery, Karolinska Institutet and Center of Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.

Background: Population-based studies of treatment of locally recurrent rectal cancer (LRRC) are lacking. The aim was to investigate the surgical treatment of patients with LRRC at a national population-based level.

Methods: All patients undergoing abdominal resection for primary rectal cancer between 1995 and 2002 in Sweden with LRRC as a first event were included. Read More

J Eng Sci Med Diagn Ther 2018 Nov 6;1(4). Epub 2018 Aug 6.

Department of Radiology, Boston Medical Center & Boston University School of Medicine, 820 Harrison Ave., Boston, MA 02118.

This paper presents the design evolution, fabrication, and testing of a novel patient and organ-specific, 3D printed phantom for external beam radiation therapy of prostate cancer. In contrast to those found in current practice, this phantom can be used to plan and validate treatment tailored to an individual patient. It contains a model of the prostate gland with a dominant intraprostatic lesion, seminal vesicles, urethra, ejaculatory duct, neurovascular bundles, rectal wall, and penile bulb generated from a series of combined T2-weighted/dynamic contrast-enhanced magnetic resonance images. Read More

OMICS J Radiol 2018 3;7(5). Epub 2018 Dec 3.

Department of Radiation Oncology, Mayo Clinic Arizona, USA.

Purpose: Intensity Modulated Radiation Therapy (IMRT) allows for significant dose reductions to organs at risk in prostate cancer patients. However, the accurate delivery of IMRT plans can be compromised by patient positioning errors. The purpose of this study was to determine if the modeling of grade ≥ 2 acute rectal toxicity could be used to monitor the quality of IMRT protocols. Read More

Cir Esp 2019 Feb 14. Epub 2019 Feb 14.

Gastrointestinal and Pancreatic Oncology Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, España.

Radiother Oncol 2019 Feb 31;131:52-59. Epub 2018 Dec 31.

Department of Radiation Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China. Electronic address:

Background And Purpose: Neoadjuvant chemoradiation (nCRT) could reduce tumor infiltrating lymphocytes. We examined absolute lymphocyte count (ALC) nadir during nCRT, pathologic response and prognosis for locally advanced rectal cancer (LARC).

Materials And Methods: 102 patients with LARC (cT3-4N0, or node-positive) treated between 2010 and 2015 with nCRT followed by complete resection were analyzed. Read More

Int J Surg 2019 Feb 14. Epub 2019 Feb 14.

Department of Gastroenterology, Surgical Division, University of Sao Paulo, Medical School, Sao Paulo, Brazil.

Pract Radiat Oncol 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiation Oncology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510 Japan.

Purpose: The purpose of this work is to demonstrate quantitatively the complementary relation between the introduction of intensity-modulated radiation therapy (IMRT) and planning target volume (PTV) margin reduction with an image-guided technique in reducing the risk of rectal toxicity in dose-escalating prostate radiation therapy.

Methods And Materials: 3D-CRT and IMRT plans were generated for 10 prostate cancer patients based on two PTV margin protocols (10/8 mm and 6/5 mm) and two dose prescriptions (70 Gy and 78 Gy). The normal tissue complication probability (NTCP) for each of eight scenarios was calculated using the Lyman-Kutcher-Burman (LKB) model to estimate the risk of rectal and bladder late toxicity. Read More

Clin Colorectal Cancer 2019 Jan 19. Epub 2019 Jan 19.

Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands; Department of Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address:

Background: The neoadjuvant rectal score (NAR) was developed as a surrogate endpoint for overall survival in patients with rectal cancer after neoadjuvant treatment. We aimed to validate the NAR score in patients from the Netherlands Cancer Registry database.

Patients And Methods: We studied patients with rectal cancer treated with long-course neoadjuvant therapy followed by surgery in the Netherlands between 2007 and 2014. Read More

Pathol Res Pract 2019 Jan 28. Epub 2019 Jan 28.

Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Gyeonggi-do 431-070, Republic of Korea.

Human epidermal growth factor 2 (HER2) is a candidate therapeutic and prognostic marker for rectal cancer treated with neoadjuvant chemoradiotherapy. The specific frequency and prognostic role of HER2 protein expression and HER2 gene amplification in those rectal cancers has not been fully investigated. Pretreatment biopsied and surgically resected formalin-fixed paraffin-embedded tissues from 74 patients were retrospectively evaluated for HER2 protein expression and HER2 gene copy number using immunohistochemistry (IHC) and silver in situ hybridization (SISH), respectively. Read More

Crit Rev Oncol Hematol 2019 Feb 9;134:71. Epub 2019 Jan 9.

Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, 8701 Watertown Plank Rd., WI, 53226, USA. Electronic address:

Int J Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, Houston Methodist Hospital, Houston, TX, USA; Department of Surgery, The University of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address:

Background: There is controversy regarding the use of laparoscopy for rectal cancer, especially after the ACOSOG Z6051 Randomized Clinical Trial determined that laparoscopy failed to meet non-inferiority compared with open surgery. With these new recommendations, the current practices for the treatment of rectal cancer across the country are unknown.

Methods: Using the ACS-NSQIP database from 2005-2016, resections for rectal cancer were studied. Read More

Int J Radiat Oncol Biol Phys 2019 Feb 13. Epub 2019 Feb 13.

Department of Radiation Oncology, Beaumont Health System, Royal Oak, MI. Electronic address:

Purpose: To update outcome and toxicity results of a prospective trial of 19 Gy single-fraction high-dose-rate (HDR) brachytherapy for men with low- and intermediate-risk prostate cancer.

Materials And Methods: Patients were treated on a prospective study of single-fraction HDR brachytherapy. All patients had low- or intermediate-risk prostate cancer. Read More

Eur J Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Pharmaceutical Sciences, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra 411038, India.

Currently cancer is the second leading cause of death globally and worldwide incidence and mortality rates of all cancers of males and females are rising tremendously. In spite of advances in chemotherapy and radiation, metastasis and recurrence are considered as the major causes of cancer related deaths. Hence there is a mounting need to develop new therapeutic modalities to treat metastasis and recurrence in cancers. Read More

Trials 2019 Feb 15;20(1):133. Epub 2019 Feb 15.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuai Fu Yuan, Dongcheng District, Beijing, 100730, People's Republic of China.

Background: Urinary catheter placement is essential before laparoscopic anterior resection for rectal cancer. Whether early removal of the catheter increases the incidence of urinary retention and urinary tract infection (UTI) is not clear. This study aims to determine the optimal time for removal of the urinary catheter after laparoscopic anterior resection of the rectum. Read More

Urol Oncol 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, Mayo Clinic Hospital, Phoenix, AZ. Electronic address:

Objectives: The length-of-stay (LOS) benefit of minimally invasive cystectomy varies in the published literature, potentially because of subgroup effects. Here, we investigated the effect of minimally invasive cystectomy on LOS among different age groups.

Methods And Materials: Adult patients who underwent cystectomy (open or minimally invasive) from January 1, 2012, to December 31, 2016, were identified from the National Surgical Quality Improvement Program database. Read More

Arab J Gastroenterol 2019 Feb 12. Epub 2019 Feb 12.

Faculty of Medicine, Cairo University, Egypt. Electronic address:

Local recurrences are more common after abdominoperineal excision (APE) than after anterior resection of rectal cancer. Extralevator APE was introduced to address this problem. The post anal minimally invasive approach had been used by other authors for transperineal mesh rectopexy but not in cancer management. Read More

Nuklearmedizin 2019 Feb 15;58(1):28-38. Epub 2019 Feb 15.

Lausanne University Hospital, Diagnostic and Interventional Radiology.

Aim: To prospectively evaluate histological significance and predictive value of changes in apparent diffusion coefficient (ADC) and F-FDG PET/CT parameters in locally advanced rectal cancer (LARC) after neoadjuvant radiochemotherapy (RCT).

Methods: Twenty-one patients with untreated LARC underwent pre-RCT and post-RCT F-FDG PET/CT and diffusion-weighted magnetic resonance imaging (DW-MRI), followed by surgery. For both datasets, two readers measured the tumor SUVmax, SUVmean, MTV, TLG, ADCmin, ADCmean, and respective differences (∆SUVmax, ∆SUVmean, ∆MTV, ∆TLG, ∆ADCmin, ∆ADCmean) for the whole tumor. Read More

Radiographics 2019 Feb 15:180114. Epub 2019 Feb 15.

From the Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY (N.H., I.P., M.J.G.); Department of Radiology, Hospital Sírio-Libanês, Adma Jafet 91, 01308-050 Bela Vista, São Paulo, Brazil (N.H., B.C.O.); and Department of Radiology, University of São Paulo, São Paulo, Brazil (N.H., C.C.T.R., B.C.O.).

Rectal cancer is prone to local recurrence and systemic metastasis. However, owing to improvements in TNM staging and treatment, including a more widespread use of rectal MRI and increased radiologist awareness of the key rectal cancer TNM staging features, the mortality rate of rectal cancer has been declining over the past few decades in adults over 50 years of age. Currently, rectal MRI plays a key role in the pre- and posttreatment evaluation of rectal cancer, assisting the multidisciplinary team in tailoring the most appropriate treatment option. Read More

Chirurg 2019 Feb 14. Epub 2019 Feb 14.

Chirurgische Klinik, Campus Virchow-Klinikum und Mitte, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

Individualized and tailored treatment plays a crucial role in the rating of special operation techniques or certain treatment strategies following defined quality criteria and indicators. Deviations from clearly defined recommendations in guidelines must therefore be justified, documented and evaluated as precisely as possible. The aim of this leading article is to examine the individualized treatment of rectal cancer based on existing evidence and to discuss its role in the light of routinely used treatment algorithms. Read More