Search Our Scientific Publications & Authors

J Surg Oncol 2021 May 7. Epub 2021 May 7.

Westat, Rockville, Maryland, USA.

Background: In the management of peritoneal metastases from colon and rectal cancer, the most favorable results are reported with an aggressive combined treatment on patients who have a small extent of the disease. A test to detect occult peritoneal metastases would greatly facilitate the management of this component of colorectal dissemination.

Methods: Currently, the standard test by which to confirm the diagnosis of the peritoneal spread of colorectal cancer is peritoneal cytology. Read More

Br J Surg 2021 May 7. Epub 2021 May 7.

Institute of Cancer Medicine, University of Liverpool, Liverpool, UK.

Sci Prog 2021 Apr-Jun;104(2):368504211016214

Department of Radiology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.

The study aimed to analyze morphometric assessment of the mesorectal fat thickness and its correlation with body mass index in Chinese Han population. The anterior, posterior, right lateral, and left lateral mesorectal fat thickness were measured using MRI T2-weighted images. The mean distance from the rectal wall to the mesorectal fascia were 3. Read More

Dis Colon Rectum 2021 Apr 29. Epub 2021 Apr 29.

Cleveland Clinic, Cleveland, Ohio.

Background: Rectal cuff and anal transitional zone neoplasia is an increasing challenge in patients with familial adenomatous polyposis who have undergone restorative proctocolectomy. Its real incidence, range of severity, and treatment efficacy are poorly documented.

Objective: We sought to document the evolution of rectal cuff and anal transitional zone neoplasia and describe its management. Read More

Int J Colorectal Dis 2021 May 7. Epub 2021 May 7.

University of Portsmouth, Portsmouth, UK.

World J Clin Oncol 2021 Apr;12(4):262-271

Department of Pathology and Laboratory Medicine, Medstar Georgetown University Hospital, Washington, DC 20007, United States.

Background: Liver tumors with dual differentiations [combined hepatocellular carcinoma (HCC) and cholangiocarcinoma] are common. However, liver tumors that exhibit hepatocellular, biliary, and neuroendocrine differentiation are exceedingly rare, with only three previous case reports in the literature.

Case Summary: A 65-year-old female with a previous history of hepatitis C and a distant history of low grade, well-differentiated rectal neuroendocrine tumor was found to have two liver lesions in segment 4 and segment 7 on imaging. Read More

Cureus 2021 Apr 2;13(4):e14264. Epub 2021 Apr 2.

Medical Oncology, Grand River Regional Cancer Centre, Kitchener, CAN.

Extragonadal germ cell tumors (EGCTs) are uncommon, and those involving the prostate are rare. We report on a primary seminoma of the prostate in a 56-year-old male presenting with scrotal pain, urinary frequency and urgency, and erectile dysfunction. Digital rectal examination revealed a hard, markedly enlarged prostate projecting posteriorly into the rectum. Read More

Ann Coloproctol 2021 May 6. Epub 2021 May 6.

Discipline of Surgery, Sydney Medical School, The University of Sydney, Sydney, Australia.

Purpose: Enhanced Recovery After Surgery (ERAS) has become standard of care in colorectal surgery. However, there is not a universally accepted colorectal ERAS protocol and significant variations in care exist between institutions. The aim of this study was to examine the impact of variations in ERAS interventions and complications on length of stay. Read More

Dis Colon Rectum 2021 Jun;64(6):e383

Department of Colon &Rectum, University of Health Science, Ankara, Turkey.

Dis Colon Rectum 2021 Jun;64(6):677-688

Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.

Background: Mucinous adenocarcinoma of the rectum accounts for 10% of all rectal cancers and has an impaired response to neoadjuvant chemoradiotherapy and worse overall survival. To date, insufficient genomic research has been performed on this histological subtype.

Objective: This study aims to define the mismatch repair deficiency rate and the driver mutations underpinning mucinous adenocarcinoma of the rectum and to compare it with rectal adenocarcinoma not otherwise specified. Read More

Dis Colon Rectum 2021 Jun;64(6):669-676

Rectal Cancer Program, Division of Colorectal Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Background: In the setting of multidisciplinary standardized care of locally advanced rectal cancer, preoperative chemoradiotherapy and total mesorectal excision have become the mainstay treatment.

Objective: This study aimed to evaluate whether the lack of preoperative chemoradiotherapy or poor response to it is associated with higher radial margin disease involvement in patients with locally advanced rectal cancer.

Design: This is a retrospective cohort study using a publicly available database. Read More

Oncologist 2021 May 6. Epub 2021 May 6.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Background: With the implementation of screening program worldwide, diagnosis of early-stage colorectal cancer steadily increased, including T1 cancer. Current T1 cancer treatment does not differ according to anatomic location. We therefore compared the disease-free survival of T1 cancer arising from rectum versus colon. Read More

Onco Targets Ther 2021 28;14:2867-2878. Epub 2021 Apr 28.

Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

Background/aims: Long non-coding ribonucleic acids (lncRNAs) are involved in the progression of cancers and affect the response to radiation therapy. This study was to investigate the mechanism of lncRNA EGOT in the radiosensitivity of rectal cancer.

Methods: The mRNA expression of EGOT, miR-211-5p and ErbB4 in rectal cancer tissues and cells was detected by qRT-PCR. Read More

Anticancer Res 2021 May;41(5):2617-2623

Department of Surgery, Yokohama City University, Yokohama, Japan.

Aim: To compare the mid-term oncological results between patients with low rectal cancer who underwent minimally invasive laparoscopic surgery (MILS) and those who underwent open surgery (OS).

Patients And Methods: Overall, 262 matched patients who underwent primary resection for low rectal cancer between 2000 and 2019 were divided into MILS (n=131; n=107, conventional laparoscopic surgery; n=24, robotic surgery) and OS (n=131) groups. The short- and mid-term outcomes were compared. Read More

Anticancer Res 2021 May;41(5):2459-2465

Department of Molecular Medicine and Surgery, Karolinska Institutet, Division of Coloproctology, Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.

Background/aim: For patients with locally recurrent rectal cancer (LRRC) extensive surgery is often the only curative option and patient selection is crucial. This study aimed to investigate whether magnetic resonance imaging (MRI) characteristics of the primary tumour can predict oncological outcome after surgery for locally recurrent rectal cancer (LRRC).

Patients And Methods: All patients undergoing surgery for LRRC with a curative intent at the Karolinska University Hospital 2003-2013 were included. Read More

World J Surg Oncol 2021 May 5;19(1):141. Epub 2021 May 5.

Department of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, China.

Background And Purpose: With the advent of more intensive chemotherapy regimens, neoadjuvant chemoradiotherapy (NACRT) for patients with locally advanced rectal cancer (LARC) has always been questioned due to its inevitable radiation toxicity. Hence, we conducted a meta-analysis to compare the clinical efficacy of neoadjuvant chemotherapy (NAC) and NACRT.

Materials And Methods: Eligible studies were searched using PubMed, MEDLINE, Embase, the Cochrane Library, and Web of Science up to 31 July 2020, comparing the clinical efficacy of NAC versus NACRT for LARC. Read More

Dis Colon Rectum 2021 Apr 26. Epub 2021 Apr 26.

Postdoctoral Research Fellow, Division of Colorectal Surgery, Department of Surgery, Columbia University Medical Center, New York, NY Postdoctoral Research Fellow, Division of Colorectal Surgery, Department of Surgery, Columbia University Medical Center, New York, NY Postdoctoral Research Fellow, Division of Colorectal Surgery, Department of Surgery, Columbia University Medical Center, New York, NY Chief, Division of Colorectal Surgery, Department of Surgery; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY Assistant Professor, Division of Colorectal Surgery, Department of Surgery; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY.

Background: Positive circumferential resection margin is a predictor of local recurrence and worse survival in rectal cancer. National programs aimed to improve rectal cancer outcomes were first created in 2011, and continue to evolve. The impact on circumferential resection margin during this timeframe has not been fully evaluated in the United States. Read More

Dis Colon Rectum 2021 Apr 26. Epub 2021 Apr 26.

From the Department of Gastroenterological Surgery, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan Gastroenterology, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan Clinical Research Center, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.

Background: Although smaller circular staplers are easier to insert and less likely to involve the vagina and levator ani muscles when performing double stapling technique anastomosis, surgeons often consider that larger circular staplers would be safer in reducing the risk of postoperative anastomotic strictures.

Objective: This study aimed to investigate the safety of using 25-mm circular staplers compared to 28/29-mm staplers in the double stapling technique anastomosis regarding the development of anastomotic strictures and other complications.

Design: Retrospective observational study. Read More

Int J Cancer 2021 May 5. Epub 2021 May 5.

Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Socioeconomic factors influence patterns of care in colorectal cancer. This study investigates the impact of socioeconomic status (SES) on stage at presentation, receipt of diagnostic imaging, receipt of treatment, and overall survival (OS) in a universal healthcare system. The Ontario Cancer Registry (OCR) was accessed to identify a cohort of patients diagnosed with colorectal adenocarcinoma from 2007-2016 in Ontario, Canada. Read More

AJR Am J Roentgenol 2021 May 5. Epub 2021 May 5.

Department of Surgical Oncology, MD Anderson Cancer Center Houston Texas 77030.

The treatment of rectal cancer centers around the distinct but related goals of management of distant metastases and management of local disease. Optimal local management requires attention to the primary tumor and its anatomic relationship to surrounding pelvic structures, with the goal of minimizing local recurrence (LR). High-resolution MRI is ideally suited for this purpose; application of MRI-based criteria in conjunction with optimized surgical and pathologic techniques have successfully reduced LR rates. Read More

J Cell Mol Med 2021 May 5. Epub 2021 May 5.

Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China.

Rectal cancer is a common malignant tumour and the progression is highly affected by the tumour microenvironment (TME). This study intended to assess the relationship between TME and prognosis, and explore prognostic genes of rectal cancer. The gene expression profile of rectal cancer was obtained from TCGA and immune/stromal scores were calculated by Estimation of Stromal and Immune cells in Malignant Tumors using Expression data (ESTIMATE) algorithm. Read More

Pol Przegl Chir 2021 Mar;93(3):1-5

Klinika Chirurgii Ogólnej i Onkologicznej Pomorskiego Uniwersytetu Medycznego, Szczecin, Polska.

Introduction: Rectal cancer is one of the most common malignancies in developed countries. However, despite the increasingly better preoperative diagnostics, adaptation of surgical techniques to the location and advancement of the tumor, the combination of surgical treatment with neoadjuvant therapy and adjuvant treatment, standardized control tests, Poland still has not obtained satisfactory results regarding long-term survival. In addition, the effects of the therapy often differ significantly from those expected by patients and the doctors treating them. Read More

Ann Nucl Med 2021 May 4. Epub 2021 May 4.

Department of Surgery, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.

Purpose: The aim of this study was to evaluate the ability of texture analysis using pretreatment F-FDG PET/CT to predict prognosis in patients with surgically treated rectal cancer.

Methods: We analyzed 94 patients with pathologically proven rectal cancer who underwent pretreatment F-FDG PET/CT and were subsequently treated with surgery. The volume of interest of the primary tumor was defined using a threshold of 40% of the maximum standardized uptake value (SUVmax), and conventional (SUVmax, metabolic tumor volume [MTV], total lesion glycolysis [TLG]) and textural PET features were extracted. Read More

J Gastrointest Surg 2021 May 4. Epub 2021 May 4.

Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, USA.

J Gastrointest Surg 2021 May 4. Epub 2021 May 4.

Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.

Cell Rep Med 2021 Apr 12;2(4):100243. Epub 2021 Apr 12.

Department of Obstetrics & Gynecology, University of Washington, Seattle, WA, USA.

Quantifying the replication-competent HIV reservoir is essential for evaluating curative strategies. Viral outgrowth assays (VOAs) underestimate the reservoir because they fail to induce all replication-competent proviruses. Single- or double-region HIV DNA assays overestimate it because they fail to exclude many defective proviruses. Read More

Am J Cancer Res 2021 15;11(4):1646-1658. Epub 2021 Apr 15.

Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital Taipei, Taiwan.

The molecular difference between synchronous and metachronous metastases in colorectal cancer (CRC) remains unclear. Between 2000 and 2010, a total of 492 CRC patients were enrolled, including 280 with synchronous metastasis and 212 with metachronous metastasis. Clinicopathological and molecular features were compared between the two groups. Read More

Rep Pract Oncol Radiother 2021 25;26(1):29-34. Epub 2021 Feb 25.

Department of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida, United States.

Background: The purpose of this study was to characterize pre-treatment non-contrast computed tomography (CT) and F-fluorodeoxyglucose positron emission tomography (PET) based radiomics signatures predictive of pathological response and clinical outcomes in rectal cancer patients treated with neoadjuvant chemoradiotherapy (NACR T).

Materials And Methods: An exploratory analysis was performed using pre-treatment non-contrast CT and PET imaging dataset. The association of tumor regression grade (TRG) and neoadjuvant rectal (NAR) score with pre-treatment CT and PET features was assessed using machine learning algorithms. Read More

Clin Cancer Res 2021 May 4. Epub 2021 May 4.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center.

Purpose: Inhibition of histone deacetylase 6 (HDAC6) is predicted to deliver both direct antitumor activity and modulation of the antitumor immune response. This study describes the development of a novel HDAC6 inhibitor.

Patients And Methods: KA2507 was characterized in HDAC biochemical and cellular target engagement assays and in preclinical efficacy models of melanoma and colorectal cancer. Read More

BMJ 2021 05 4;373:n877. Epub 2021 May 4.

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, 171 77 Stockholm, Sweden

Objective: To assess the risk of colorectal cancer (CRC) in first degree relatives (parents and full siblings) of patients with precursor lesions (polyps) for CRC.

Design: Case-control study.

Setting: Linkage to the multi-generation register and gastrointestinal ESPRESSO (Epidemiology Strengthened by histoPathology Reports in Sweden) histopathology cohort in Sweden. Read More