77,617 results match your criteria Rectal Cancer


Same-day hospital discharge after minimally invasive hysterectomy in a gynecologic oncology practice: Feasibility, safety, predictors of admission and adverse outcomes.

J Minim Invasive Gynecol 2022 May 17. Epub 2022 May 17.

Division of Gynecologic Oncology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Study Objectives: 1) Determine the feasibility and safety of same-day hospital discharge (SDHD) after minimally invasive hysterectomy (MIH) in a gynecologic oncology practice, 2) Detail predictors of immediate post-operative hospital admission and multiple 30-day adverse outcomes.

Design: Retrospective cohort study.

Setting: University of Pittsburgh Medical Center Magee-Womens Hospital. Read More

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Clinical outcomes of surgical and imatinib treatment for rectal gastrointestinal stromal tumours: retrospective cohort study.

BJS Open 2022 May;6(3)

Department of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan.

Background: Rectal gastrointestinal stromal tumours (GISTs) are rare and treated mainly by radical surgery. Although the importance of perioperative imatinib has been recognized, there are few reports on its outcomes.

Method: Consecutive patients diagnosed with rectal GISTs between July 2008 and February 2021 were identified from a prospective database. Read More

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Comprehensive anatomy of the superior hypogastric plexus and its relationship with pelvic surgery landmarks: defining the safe zone around the promontory.

Tech Coloproctol 2022 May 20. Epub 2022 May 20.

Department of General Surgery and Anatomy, Faculty of Medicine, Ankara University, Sıhhıye, 06100, Ankara, Turkey.

Background: Pelvic surgery carries an inherent risk of autonomic nerve injury leading to genitourinary and bowel dysfunction due to the close proximity of the superior hypogastric plexus (SHP). The aim of this study was to define the detailed anatomy of SHP and identify its relationship with the vascular landmarks and ureters for pelvic autonomic nerve-preserving surgery.

Methods: A cadaveric study on the detailed anatomy of the SHP was conducted in our surgical anatomy research unit. Read More

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Endoscopic electrocauterization for management of chronic perineal sinus following abdominoperineal resection.

J Surg Case Rep 2022 May 17;2022(5):rjac194. Epub 2022 May 17.

Department of Colon and Rectal Surgery, Summa Health System, Akron, OH, USA.

We present a case of a chronic perineal sinus following abdominoperineal resection with management via endoscopic electrocauterization. This patient presented with 1 year of bloody, mucus drainage from a perineal wound following abdominoperineal resection for anastomotic leak and stricture from a remote low anterior resection for T2N1 rectal cancer. We describe a novel use of endoscopic electrocautery to debride, de-epithelialize and ultimately eliminate the sinus cavity. Read More

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RIOK1 mediates p53 degradation and radioresistance in colorectal cancer through phosphorylation of G3BP2.

Oncogene 2022 May 19. Epub 2022 May 19.

Department of Colorectal Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China.

RIO Kinase 1 (RIOK1) is involved in various pathologies, including cancer. However, the role of RIOK1 in radioresistance of colorectal cancer (CRC) remains largely unknown. In this study, we reported that RIOK1 was overexpressed in rectal cancer tissue with weaker tumor regression after neoadjuvant chemoradiotherapy (neoCRT). Read More

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Patient-reported bowel and urinary function in long-term survivors of squamous cell carcinoma of the anus treated with definitive intensity-modulated radiotherapy and concurrent chemotherapy.

Int J Radiat Oncol Biol Phys 2022 May 16. Epub 2022 May 16.

Department of Gastrointestinal Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.

Background: Definitive radiotherapy with concurrent chemotherapy is curative for non-metastatic squamous cell carcinoma of the anus (SCCA). However, the true impact of chemoradiation on long-term functional outcomes is poorly understood due to limited follow up and patient-reported outcomes (PROs).

Methods: We conducted a cross-sectional survey of 248 patients with SCCA treated with definitive intensity-modulated radiation (IMRT) and concurrent chemotherapy from 2010-2018 who were alive and without recurrence. Read More

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Identification of high-risk stage I colon and rectal cancer patients: a retrospective analysis of a large Japanese cohort.

Int J Colorectal Dis 2022 May 19. Epub 2022 May 19.

Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.

Purpose: Data regarding risk factors for recurrence in stage I colorectal cancer patients are limited. The aim of this study was to clarify the existence of a high-recurrence-risk population among stage I colorectal cancer patients.

Methods: This analysis included 7,539 stage I colorectal cancer patients treated between 1997 and 2012 at 24 leading hospitals in Japan. Read More

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A Deep Learning Model Based on MRI and Clinical Factors Facilitates Noninvasive Evaluation of KRAS Mutation in Rectal Cancer.

J Magn Reson Imaging 2022 May 19. Epub 2022 May 19.

Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Recent studies showed the potential of MRI-based deep learning (DL) for assessing treatment response in rectal cancer, but the role of MRI-based DL in evaluating Kirsten rat sarcoma viral oncogene homologue (KRAS) mutation remains unclear.

Purpose: To develop a DL method based on T2-weighted imaging (T2WI) and clinical factors for noninvasively evaluating KRAS mutation in rectal cancer.

Study Type: Retrospective. Read More

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Systematic Analysis of E2F Expression and Its Relation in Colorectal Cancer Prognosis.

Int J Gen Med 2022 11;15:4849-4870. Epub 2022 May 11.

Department of Hernia and Colorectal Surgery, The Second Hospital of Dalian Medical University, Dalian, People's Republic of China.

Background: The E2 factor (E2F) family of transcription factors is dysregulated in numerous cancer types and may play a vital role in the development of various malignancies. However, to our knowledge, the specific function of each of the E2Fs and their relation to the disease prognosis of colorectal cancer (CRC) patients remain unknown.

Materials And Methods: We used different publicly available databases and tools, such as ONCOMINE, GEPIA2, UALCAN, cBioPortal, Kaplan-Meier plotter, Metascape, and TIMER analysis, to do an in silico exploration of the potential roles of E2Fs in CRC. Read More

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High dose chemoradiotherapy increases chance of organ preservation with satisfactory functional outcome for rectal cancer.

Radiat Oncol 2022 May 18;17(1):98. Epub 2022 May 18.

Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.

Background: High dose chemoradiotherapy offers a curative chance for patients with rectal cancer that are unfit or unwilling to undergo surgical resection, yet its long-term survival and functional outcomes have been rarely investigated.

Methods: Patients with non-metastatic rectal adenocarcinoma who received pelvic radiation for curative intent from April 2006 to July 2017 were retrospectively investigated. Survival rates were analyzed using the Kaplan-Meier method. Read More

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Postoperative colon perforation due to the tip of the transanal decompression tube after laparoscopic low anterior resection: A case report.

Asian J Endosc Surg 2022 May 18. Epub 2022 May 18.

Department of Gastroenterological Surgery, Hakodate Municipal Hospital, Hakodate, Hokkaido, Japan.

A 66-year-old man underwent laparoscopic low anterior resection for rectal cancer. A transanal decompression tube (24Fr Nelaton catheter) was placed laparoscopically during the surgery. Contrast enema on postoperative day 5 showed perforation of the sigmoid colon around the tip of the tube, and emergency laparotomy was performed. Read More

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Risk factors and economic burden of postoperative anastomotic leakage related events in patients who underwent surgeries for colorectal cancer.

PLoS One 2022 18;17(5):e0267950. Epub 2022 May 18.

Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Nationwide research about the clinical and economic burden caused by anastomotic leakage (AL) has not been published yet in Korea. This study assessed the AL rate and quantified the economic burden using the nationwide database.

Methods: This real world evidence study used health claims data provided by the Korean Health Insurance Review and Assessment Service (HIRA, which showed that 156,545 patients underwent anterior resection (AR), low anterior resection (LAR), or ultra-low anterior resection (uLAR) for colorectal cancer (CRC) between January 1, 2007 and January 31, 2020. Read More

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The SAGES MASTERS program presents: the 10 seminal articles for the Laparoscopic Right Colectomy Pathway.

Surg Endosc 2022 May 18. Epub 2022 May 18.

Division of Colon and Rectal Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: As one of the 12 clinical pathways of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) Masters Program, the Colorectal Pathway intends to deliver didactic content organized along 3 levels of performance (competency, proficiency and mastery) each represented by an anchoring procedure (laparoscopic right colectomy, laparoscopic left/sigmoid colectomy, and intracorporeal anastomosis during minimally invasive (MIS) ileocecal or right colon resection). In this article, the SAGES Colorectal Task Force presents focused summaries of the top 10 seminal articles selected for laparoscopic right colectomy which surgeons should be familiar with.

Methods: Using a systematic literature search of Web of Science, the most cited articles on laparoscopic right colectomy were identified, reviewed, and ranked by the SAGES Colorectal Task Force and invited subject experts. Read More

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Laparoscopic TME and hepatic resection after total neoadjuvant chemotherapy plus short course radiotherapy for low rectal cancer with single synchronous liver metastases.

Authors:
F Crafa S Vanella

Colorectal Dis 2022 May 18. Epub 2022 May 18.

General and Oncological Surgery Unit, Hospital of National Relevance and High Specialty "St. Giuseppe Moscati", Avellino -, Italy.

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Anastomotic Leak Rate and Prolonged Postoperative Paralytic Ileus in Patients Undergoing Laparoscopic Surgery for Colo-Rectal Cancer After Placement of No-Coil Endoanal Tube.

Surg Innov 2022 May 17:15533506221090995. Epub 2022 May 17.

Science of Health Department, General Surgery Unit, University "Magna Graecia" Medical School, Catanzaro, Italy.

Background: Colorectal cancer (CRC) is the second most common gastrointestinal tumor in men and the third in women. Left-hemicolectomy (LC) and low anterior resection (LAR) are considered the gold standard curative treatment. In this retrospective study, we evaluated the presence or absence of post-operative complications, in all patients who underwent Video-laparoscopic (VLS) LAR/LC with No Coil trans-anal tube positioning, and compared the data with the current literature on the topic. Read More

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Endoluminal vacuum-assisted therapy to treat rectal anastomotic leakage: A critical analysis.

World J Gastroenterol 2022 Apr;28(14):1394-1404

Department of Gastrointestinal Surgery, IRCCS San Raffaele Scientific Institute, Milano 20132, Italy.

Endoluminal vacuum-assisted therapy (EVT) has been introduced recently to treat colorectal anastomotic leaks in clinically stable non-peritonitic patients. Its application has been mainly reserved to low colorectal and colo-anal anastomoses. The main advantage of this new procedure is to ensure continuous drainage of the abscess cavity, to promote and to accelerate the formation of granulation tissue resulting in a reduction of the abscess cavity. Read More

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Mesentery solitary fibrous tumor with postoperative recurrence and sarcomatosis: A case report and review of literature.

World J Clin Oncol 2022 Apr;13(4):303-313

Peritoneal Surface Malignancy Center, Kishiwada Tokushukai Hospital, Osaka 596-8522, Japan.

Background: Solitary fibrous tumors are rare neoplasms of mesenchymal origin. They are often of low malignant potential and rarely metastasize. They frequently arise from the pleura and can occur at any soft tissue site in the body. Read More

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Diffusion-weighted magnetic resonance imaging at 1.5 T for peripheral zone prostate cancer: the influence of the -value combination on the diagnostic performance of apparent diffusion coefficient.

Pol J Radiol 2022 8;87:e215-e219. Epub 2022 Apr 8.

Department of Radiologic Sciences and Medical Physics, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Purpose: Diffusion-weighted imaging as a noninvasive functional modality plays a valuable role in the evaluation of prostate cancer. However, there is still no agreement on the number and range of -values to be used. Therefore, the purpose of this study is to investigate the influence of -value choice on the diagnostic performance of apparent diffusion coefficient (ADC) values for prostate cancer detection. Read More

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The awareness of radiologists for the presence of lateral lymph nodes in patients with locally advanced rectal cancer: a single-centre, retrospective cohort study.

Eur Radiol 2022 May 18. Epub 2022 May 18.

Department of Surgery, Amsterdam UMC location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands.

Objectives: Enlarged lateral lymph nodes (LLNs) are associated with increased (lateral) local recurrence rates. Size and anatomical location should therefore always be reported by radiologists and discussed during multidisciplinary meetings. The objective was to investigate how often LLNs are mentioned in MRI reports in a tertiary referral centre. Read More

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Who is a candidate for nonoperative management of early-stage rectal cancer?

Clin Adv Hematol Oncol 2022 May;20(5):281-283

Mayo Clinic, Rochester, Minnesota.

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Folate intake and risk of colorectal cancer: a systematic review and up-to-date meta-analysis of prospective studies.

Eur J Cancer Prev 2022 May 11. Epub 2022 May 11.

College of Food Science, Southwest University, Chongqing, China.

Purpose: Colorectal cancer is one of the most commonly diagnosed and deadly cancers worldwide. Epidemiological studies on the relationship between folate intake and the risk of colorectal cancer have reported inconsistent findings since folate fortification in the USA. For this situation, we conducted a large number of data analyses to study the relationship between folate intake and colorectal cancer risk. Read More

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[A Case of Fournier's Gangrene during Second-Line IRIS plus Bevacizumab Chemotherapy for Rectal and Anal Canal Cancer].

Gan To Kagaku Ryoho 2022 May;49(5):597-599

Dept. of Medical Oncology, Tokyo Saiseikai Central Hospital.

A 52-year-old man diagnosed with Stage ⅢA rectal and anal canal cancer underwent abdominal perineal resection using Miles's method. Two years later, local recurrence and lung metastases were detected using contrasted CT imaging. First-line chemotherapy of XELOX was administered for 4 months until the disease progressed and lung metastases developed. Read More

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[A Case of Delayed Anastomotic Leakage after Ileocecal Resection in a Hemodialysis Patient].

Gan To Kagaku Ryoho 2022 May;49(5):585-587

Dept. of Surgery, Ageo Central General Hospital.

A 66-year-old man was referred to our department with the diagnosis of ascending colon cancer. He was undergoing dialysis for chronic renal failure due to diabetic nephropathy. Laparoscopic ileocecal resection was planned for the ascending colon cancer, but the procedure was converted to laparotomy owing to intraoperative bleeding. Read More

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A new technique for robotic lateral pelvic lymph node dissection for advanced low rectal cancer with emphasis on en bloc resection and inferior vesical vessel preservation.

Surg Endosc 2022 May 16. Epub 2022 May 16.

Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Background: Lateral pelvic lymph node (LPLN) dissection is becoming increasingly important in the treatment of advanced low rectal cancer patients. However, the surgery has several disadvantages, including its technical complexity and high risk of urinary dysfunction. Herein, we report a new technique for robotic lateral pelvic lymph node dissection for advanced low rectal cancer with emphasis on en bloc resection and inferior vesical vessel preservation. Read More

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Hereditary Colorectal Cancer.

Hematol Oncol Clin North Am 2022 May 13. Epub 2022 May 13.

Division of Gastroenterology, Hepatology & Nutrition, The Ohio State University Wexner Medical Center, 395 W 12th Avenue, Second Floor, Columbus, OH 43210, USA. Electronic address: https://twitter.com/docstanich.

Around 10% to 16% of colorectal cancer patients have a pathogenic variant in a cancer susceptibility gene. Some of these variants are in cancer genes that are associated with colorectal cancer while others are not. The hereditary colorectal cancer syndromes can be divided into two major categories, the nonpolyposis and the polyposis conditions. Read More

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Management of Rectal Cancer.

Hematol Oncol Clin North Am 2022 May 13. Epub 2022 May 13.

Gastrointestinal Cancer Center, Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

Rectal cancer is an aggressive subtype of colon cancer with inferior outcomes in terms of disease-free and overall survival. Localized rectal cancer should be managed surgically. For stage II and III rectal cancer, neoadjuvant radiation, either as long-course chemoradiotherapy with a sensitizing fluoropyrimidine or short-course radiation, should be offered in all cases. Read More

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Impact of near-infrared fluorescence imaging with indocyanine green on structural sequelae of anastomotic leakage after laparoscopic intersphincteric resection of malignant rectal tumors.

Tech Coloproctol 2022 May 16. Epub 2022 May 16.

Department of Colorectal Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

Background: Recent studies have indicated the potential benefit of intraoperative near-infrared fluorescence imaging (NIR-FI) with indocyanine green in reducing early anastomotic leakage in colorectal surgery. Nonetheless, whether NIR-FI is effective in reducing structural sequelae of anastomotic leakage (SSAL) remains unclear. The aim of the present study was to investigate the impact of NIR-FI on SSAL after laparoscopic intersphincteric resection (ISR) of malignant rectal tumors. Read More

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Robotic supralevator total pelvic exenteration with lateral pelvic sidewall dissection for rectal cancer.

Tech Coloproctol 2022 May 16. Epub 2022 May 16.

Department of Gastrointestinal Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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Editorial for "A Deep Learning Model Based on MRI and Clinical Factors Facilitates Noninvasive Prediction of KRAS Mutation in Rectal Cancer".

J Magn Reson Imaging 2022 May 16. Epub 2022 May 16.

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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