70,101 results match your criteria Rectal Cancer


Robotic intersphincteric resection with TME and coloanal anastomosis: a video vignette.

Colorectal Dis 2020 Jun 3. Epub 2020 Jun 3.

Division of Oncological and Robotic General Surgery, Careggi University Hospital, Florence, Italy.

The advances in oncology and the application of new technology in surgery have increased the use of sphincter-preserving procedures for the treatment of low rectal cancer. [1] Additionally, traditional ultralow anterior resection for rectal cancer results frequently in bowel, urinary and sexual dysfunctions. [2]. Read More

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http://dx.doi.org/10.1111/codi.15179DOI Listing

Author response to: Beyond T, N and M: can lateral lymph node dissection treat tumour deposits in advanced low rectal carcinoma?

Br J Surg 2020 Jun 3. Epub 2020 Jun 3.

Department of Colorectal Surgery, National Cancer Centre Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1002/bjs.11743DOI Listing

Two-Stage Turnbull-Cutait Pull-Through Coloanal Anastomosis for Low Rectal Cancer: A Randomized Clinical Trial.

JAMA Surg 2020 Jun 3:e201625. Epub 2020 Jun 3.

Colorectal Unit, IDIBELL, Bellvitge University Hospital, Department of General and Digestive Surgery, University of Barcelona, Barcelona, Spain.

Importance: Two-stage Turnbull-Cutait pull-through hand-sewn coloanal anastomosis seems to provide benefits in terms of postoperative morbidity compared with standard hand-sewn coloanal anastomosis associated with diverting ileostomy and further ileostomy reversal in patients operated on for low rectal cancer.

Objective: To compare 30-day postoperative and 1-year follow-up results of Turnbull-Cutait pull-through hand-sewn coloanal anastomosis and standard hand-sewn coloanal anastomosis after ultralow rectal resection for rectal cancer.

Design, Setting, And Participants: Multicenter randomized clinical trial. Read More

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http://dx.doi.org/10.1001/jamasurg.2020.1625DOI Listing

Short- And medium-term outcomes of reduced-port laparoscopic surgery in elderly patients with upper rectal cancer: A retrospective cohort study.

Cancer Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Surgery, Wenling First People's Hospital, Wenling City, People's Republic of China.

Background: To investigate the short- and medium-term outcomes of using a reduced-port laparoscopic surgery (RPLS), compared to multi-port laparoscopic surgery (MPLS), for the treatment of upper rectal cancer (URC) among elderly patients.

Methods: We conducted a retrospective analysis of the clinical and follow-up data of 181 elderly patients with URC, who underwent radical laparoscopic surgery at our hospital, between January 2015 and January 2019. Among these 181 cases, 62 underwent RPLS and 119 MPLS. Read More

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http://dx.doi.org/10.1002/cam4.3070DOI Listing

Long-term survival outcomes following laparoscopic surgery for clinical stage 0/I rectal carcinoma.

Ann Gastroenterol Surg 2020 May 20;4(3):294-300. Epub 2020 May 20.

Department of Surgery Kitasato Institute Hospital Kitasato University Tokyo Japan.

Aim: To clarify and evaluate the long-term outcomes of laparoscopic surgery for clinical stage 0/I rectal carcinoma patients.

Methods: This single-arm phase II trial involved accredited surgeons from 43 Japanese institutions. Patients were registered preoperatively. Read More

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http://dx.doi.org/10.1002/ags3.12333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240150PMC

Application of Mitochondrially Targeted Nanoconstructs to Neoadjuvant X-ray-Induced Photodynamic Therapy for Rectal Cancer.

ACS Cent Sci 2020 May 24;6(5):715-726. Epub 2020 Apr 24.

ARC Centre of Excellence for Nanoscale Biophotonics, Graduate School of Biomedical Engineering, University of New South Wales, Kensington, New South Wales 2052, Australia.

In this work, we brought together two existing clinical techniques used in cancer treatment-X-ray radiation and photodynamic therapy (PDT), whose combination termed X-PDT uniquely allows PDT to be therapeutically effective in deep tissue. To this end, we developed mitochondrially targeted biodegradable polymer poly(lactic--glycolic acid) nanocarriers incorporating a photosensitizer verteporfin, ultrasmall (2-5 nm) gold nanoparticles as radiation enhancers, and triphenylphosphonium acting as the mitochondrial targeting moiety. The average size of the nanocarriers was about 160 nm. Read More

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http://dx.doi.org/10.1021/acscentsci.9b01121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256935PMC

Pitfalls of FDG-PET in the prostate for the surgical oncologist.

Urol Case Rep 2020 Nov 22;33:101262. Epub 2020 May 22.

Department of Surgery, University of Melbourne, Austin Hospital, Heidelberg, Australia.

A 78-year-old man was referred for investigation of prostate cancer following incidental uptake on 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET). Despite normal PSA and benign digital rectal exam, he was referred for consideration of trans-perineal biopsy to exclude prostate cancer. It was only on review of imaging that it became clearly apparent that the 18F-FDG uptake was due to urinary tracer pooling in a trans-urethral resection cavity. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262006PMC
November 2020

Hemorrhagic Cholecystitis in a Patient with Cirrhosis and Rectal Cancer.

Cureus 2020 Apr 29;12(4):e7882. Epub 2020 Apr 29.

Internal Medicine, Citrus Memorial Hospital, Inverness, USA.

Hemorrhagic cholecystitis is a rare presentation of acute calculous cholecystitis which presents with abdominal pain, jaundice, and gastrointestinal bleeding. It is a challenging diagnosis to make because it present similar to other common disorders such as calculous cholecystitis. We present a unique case of hemorrhagic cholecystitis in a patient with cirrhosis and rectal cancer. Read More

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http://dx.doi.org/10.7759/cureus.7882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255552PMC

The prognostic importance of MRI detected extramural vascular invasion (mrEMVI) in locally advanced rectal cancer.

Int J Colorectal Dis 2020 Jun 2. Epub 2020 Jun 2.

Department of Surgery, Northwest clinics, PO box 501, 1815 JD, Alkmaar, The Netherlands.

Background: MRI detected extramural vascular invasion (mrEMVI) is a poor prognostic factor in rectal cancer patients. The objectives of this study were to assess survival outcomes in patients with and without mrEMVI and to compare the prognostic value of mrEMVI with other rectal cancer features.

Methods: In a Dutch high volume rectal cancer center cohort of sixty-seven locally advanced rectal cancer patients, an independent radiologist reviewed all primary staging MRI scans. Read More

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http://dx.doi.org/10.1007/s00384-020-03632-9DOI Listing

Induction chemotherapy followed by neoadjuvant chemoradiotherapy and surgery for patients with locally advanced rectal cancer: a systematic review and meta-analysis.

Int J Colorectal Dis 2020 Jun 1. Epub 2020 Jun 1.

The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, China.

Background: Controversy persists about whether additional induction chemotherapy (ICT) before neoadjuvant chemoradiation (NCRT) yields improved oncological outcomes. We performed a systematic review and meta-analysis to compare ICT+ NCRT+ surgery(S) with NCRT+ S in patients with locally advanced rectal cancer (LARC).

Methods: We searched the PubMed, EMBASE, Cochrane Library, and China Biology Medicine (CBM) databases. Read More

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http://dx.doi.org/10.1007/s00384-020-03621-yDOI Listing

Neoadjuvant Treatment in Upper Rectal Cancer Does Not Improve Oncologic Outcomes But Increases Postoperative Morbidity.

Anticancer Res 2020 Jun;40(6):3579-3587

Department of Digestive, Oncological, Endocrine, Hepato-Biliary, Pancreatic and Liver Transplant Surgery, Trousseau Hospital, Chambray Les Tours, France

Background/aim: Neoadjuvant chemoradiation/radiation therapy in locally advanced (LA) upper rectal adenocarcinoma management remains unclear. The aim of this study was to compare outcomes between neoadjuvant chemoradiation therapy (CRT) and upfront surgery (US).

Patients And Methods: A total of 127 patients were retrospectively included from 5 centers (79 treated with US and 48 with CRT). Read More

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http://dx.doi.org/10.21873/anticanres.14348DOI Listing

Umbilical Defunctioning Ileostomy for Rectal Cancer Results in Reduced Risk for Incisional Hernia.

Anticancer Res 2020 Jun;40(6):3445-3451

Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.

Background/aim: Umbilical defunctioning ileostomy (UDI) spares one incision, which may reduce the overall incidence of incisional hernia. Our aim was to evaluate the occurrence and risk factors of incisional hernias between UDI and conventional defunctioning ileostomy (CDI) after ileostomy closure.

Patients And Methods: Incidence of incisional hernia after ileostomy closure was compared between UDI (n=51) and CDI (n=86) groups. Read More

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http://dx.doi.org/10.21873/anticanres.14330DOI Listing

Juvenile polyposis syndrome might be misdiagnosed as familial adenomatous polyposis: a case report and literature review.

BMC Gastroenterol 2020 Jun 1;20(1):167. Epub 2020 Jun 1.

Department of Colorectal Surgery, Changhai Hospital, 168 Changhai Road, Shanghai, 200433, China.

Background: Juvenile polyposis syndrome (JPS) is a rare disorder characterized by the presence of multiple juvenile polyps in the gastrointestinal tract, and germline mutations in SMAD4 or BMPR1A. Due to its rarity and complex clinical manifestation, misdiagnosis often occurs in clinical practice.

Case Presentation: A 42-year-old man with multiple pedunculated colorectal polyps and concomitant rectal adenocarcinoma was admitted to our hospital. Read More

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http://dx.doi.org/10.1186/s12876-020-01238-7DOI Listing

Optimize the dose of oxaliplatin for locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy followed by radical surgery and adjuvant chemotherapy.

BMC Cancer 2020 Jun 1;20(1):498. Epub 2020 Jun 1.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.

Background: Addition of oxaliplatin to capecitabine remains controversial for locally advanced rectal cancer (LARC). And cumulative oxaliplatin dose (COD) varied among clinical trials showing different therapeutic effects of this regimen. The objective of this study was to explore how COD affected tumor metastasis and patient survival. Read More

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http://dx.doi.org/10.1186/s12885-020-06988-xDOI Listing

The Use of Enhanced Technologies in Robotic Surgery and Its Impact on Outcomes in Rectal Cancer: A Systematic Review.

Surg Innov 2020 Jun 2:1553350620928277. Epub 2020 Jun 2.

Department of Colorectal Surgery, 112006 Queen Alexandra Hospital , UK.

The main advantage of the robotic approach is the surgical precision that the technology offers. It is particularly useful in rectal cancer as this is a technically challenging procedure. The technological advantage of the robot leads to better postoperative outcomes. Read More

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http://dx.doi.org/10.1177/1553350620928277DOI Listing

Increasing incidence of colorectal cancer among the younger population in Sweden.

BJS Open 2020 Jun 2. Epub 2020 Jun 2.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Background: The incidence of colorectal cancer in patients aged less than 50 years is increasing in Western countries. This population-based study investigated the age- and sex-specific incidence of colorectal cancer over time in Sweden, and characterized trends in tumour localization and stage at diagnosis.

Methods: Patients diagnosed with colorectal cancer between 1970 and 2016 were identified from the Swedish Cancer Registry, and categorized by sex, age and tumour location. Read More

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http://dx.doi.org/10.1002/bjs5.50279DOI Listing

Impact of rectal perforation on recurrence during rectal cancer surgery in a national population registry.

Br J Surg 2020 Jun 2. Epub 2020 Jun 2.

Skåne University Hospital, Malmö, Lund University, Malmö, Sweden.

Background: Incidental perforation in rectal cancer surgery is considered a risk factor for poorer oncological outcome. Most studies emanate from the era before total mesorectal excision when staging, neoadjuvant treatment and surgical technique were suboptimal. This study assessed the impact of incidental perforation on oncological outcome in a cohort of patients with optimized management. Read More

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http://dx.doi.org/10.1002/bjs.11710DOI Listing

Colon and rectal cancer survival in seven high-income countries 2010-2014: variation by age and stage at diagnosis (the ICBP SURVMARK-2 project).

Gut 2020 Jun 1. Epub 2020 Jun 1.

Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France

Objectives: As part of the International Cancer Benchmarking Partnership (ICBP) SURVMARK-2 project, we provide the most recent estimates of colon and rectal cancer survival in seven high-income countries by age and stage at diagnosis.

Methods: Data from 386 870 patients diagnosed during 2010-2014 from 19 cancer registries in seven countries (Australia, Canada, Denmark, Ireland, New Zealand, Norway and the UK) were analysed. 1-year and 5-year net survival from colon and rectal cancer were estimated by stage at diagnosis, age and country, RESULTS: (One1-year) and 5-year net survival varied between (77. Read More

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http://dx.doi.org/10.1136/gutjnl-2020-320625DOI Listing

[Genetic variations in apoptosis genes are associated with acute adverse events in postoperative rectal cancer patients receiving concurrent chemoradiotherapy].

Zhonghua Zhong Liu Za Zhi 2020 May;42(5):376-382

State Key Laboratory of Molecular Oncology, Department of Etiology & Carcinogenesis, Beijing Key Laboratory for Carcinogenesis and Cancer Prevention, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To investigate the associations between the genetic variations of apoptosis genes and the adverse events of postoperative concurrent chemoradiotherapy in patients with rectal cancer. We enrolled 362 patients with stage Ⅱ to Ⅲ rectal cancer who received concurrent chemoradiotherapy. Whole blood sample (2 ml) was collected from patient at the time of enrollment before therapy. Read More

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http://dx.doi.org/10.3760/cma.j.cn112152-112152-20190801-00488DOI Listing

Management of locally advanced synchronous colorectal and prostate cancers: A case report.

Medicine (Baltimore) 2020 May;99(22):e20336

Department of Radiation Oncology, National University Cancer Institute, Singapore (NCIS), National University Health Systems (NUHS), Singapore.

Introduction: Synchronous colorectal and prostate malignancies are uncommon, with standard treatment guidelines not yet established. Chemoradiation therapy is involved in both colorectal and prostate cancers. However, differing dosage regimens and effects of irradiation field on anatomical planes for surgery makes management of the synchronous cancers challenging. Read More

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http://dx.doi.org/10.1097/MD.0000000000020336DOI Listing

A controlled study on the efficacy and quality of life of laparoscopic intersphincteric resection (ISR) and extralevator abdominoperineal resection (ELAPE) in the treatment of extremely low rectal cancer.

Medicine (Baltimore) 2020 May;99(22):e20245

Department of Gastrointestinal Surgery, West China Hospital of Sichuan University.

Background: The aim of this study is to compare the postoperative quality of life (QoL) and survival outcomes in lower rectal cancer (LRC) patients who undergo either laparoscopic- intersphincteric resection or extralevator abdominoperineal excision (L-ELAPE) after long-course neoadjuvant chemoradiation therapy (nCRT).

Methods: This prospective, single-center, non-randomized, controlled, non-blinded, phase I/II clinical trial is designed to enroll 159 eligible LRC patients who achieved favorable response to long-course nCRT (2 × 25 Gy). After informed consent, the patients will be assigned into the laparoscopic intersphincteric resection group or L-ELAPE group according to their own will. Read More

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http://dx.doi.org/10.1097/MD.0000000000020245DOI Listing

Preoperative imatinib and laparoscopic intersphincteric resection for large rectal gastrointestinal stromal tumor: A case report.

Int J Surg Case Rep 2020 May 23;71:235-239. Epub 2020 May 23.

Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2-E2 Yamadaoka, Suita City, Osaka 565-0871, Japan.

Introduction: Anus-preserving surgery for a large rectal gastrointestinal stromal tumor (GIST) may be difficult because of the location of the tumor in the pelvis. Therefore, rectal GIST might require extensive surgery, such as abdominoperineal resection. In recent years, preoperative imatinib therapy has been used to reduce tumor size and preserve the anus in some cases. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262371PMC

Interdisciplinary Surgical Approaches in Vaginal and Perineal Reconstruction of Advanced Rectal and Anal Female Cancer Patients.

Front Oncol 2020 13;10:719. Epub 2020 May 13.

Department of Plastic and Hand Surgery, University Hospital Erlangen-Friedrich Alexander University of Erlangen-Nuernberg FAU, Erlangen, Germany.

Relapsing or far advanced rectal and anal cancers remain difficult to treat and require interdisciplinary approaches. Due to modern standard protocols all patients receive irradiation and neoadjuvant chemotherapy-and in case of a relapse a second irradiation-rendering the surgical site prone to surgical site infections and oftentimes long lasting sinus and septic complications after exenteration in the pelvis. Despite an improved overall survival rate in these patients the downside of radical tumor surgery in the pelvis is a major loss of quality of life, especially in women when parts of the vagina need to be resected. Read More

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http://dx.doi.org/10.3389/fonc.2020.00719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237715PMC

Development of Volumetric Independent Dose Calculation System for Verification of the Treatment Plan in Image-Guided Adaptive Brachytherapy.

Front Oncol 2020 13;10:609. Epub 2020 May 13.

Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States.

This study aimed to develop a volumetric independent dose calculation (vIDC) system for verification of the treatment plan in image-guided adaptive brachytherapy (IGABT) and to evaluate the feasibility of the vIDC in clinical practice with simulated cases. The vIDC is based on the formalism of TG-43. Four simulated cases of cervical cancer were selected to retrospectively evaluate the dose distributions in IGABT. Read More

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http://dx.doi.org/10.3389/fonc.2020.00609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237701PMC

Radiomics-Based Preoperative Prediction of Lymph Node Status Following Neoadjuvant Therapy in Locally Advanced Rectal Cancer.

Front Oncol 2020 11;10:604. Epub 2020 May 11.

Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, China.

Lymph node status is a key factor for the recommendation of organ preservation for patients with locally advanced rectal cancer (LARC) following neoadjuvant therapy but generally confirmed post-operation. This study aimed to preoperatively predict the lymph node status following neoadjuvant therapy using multiparametric magnetic resonance imaging (MRI)-based radiomic signature. A total of 391 patients with LARC who underwent neoadjuvant therapy and TME were included, of which 261 and 130 patients were allocated to the primary cohort and the validation cohort, respectively. Read More

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http://dx.doi.org/10.3389/fonc.2020.00604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233118PMC

Epidural dexmedetomidine infusion in a patient with chronic opioid use and intractable pain following abdominoperineal resection.

Oxf Med Case Reports 2020 Apr 23;2020(4):omaa021. Epub 2020 May 23.

Faculty of Medicine, Northern Ontario Medical School, Lakehead University, Thunder Bay, ON, Canada.

Dexmedetomidine is a selective alpha 2 adrenergic agonist with known analgesic properties. Its perioperative use is associated with reduced pain scores and an opioid sparing effect. Management of postoperative pain in patients with a history of chronic opioid use can be challenging. Read More

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http://dx.doi.org/10.1093/omcr/omaa021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243718PMC

Rectal neuroendocrine carcinoma: case report of a rare entity and perspective review of promising agents.

Drugs Context 2020 15;9. Epub 2020 May 15.

Medical Oncology Department, Catalan Institute of Oncology (ICO)-Badalona; Badalona-Applied Research Group in Oncology (B-ARGO)-Germans Trias i Pujol Institute (IGTP); Germans Trias i Pujol University Hospital (HUGTiP), Badalona, Barcelona, Spain.

Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of tumours, which can be classified into neuroendocrine tumours (NETs), neuroendocrine carcinomas (NECs) and mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs). To date, there is no consensus regarding the optimal therapy, which usually depends on the primary location and classification, according to morphological features of differentiation and proliferation rates. Nevertheless, multidisciplinary strategies combining medical treatments and locoregional strategies have yielded better efficacy results. Read More

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http://dx.doi.org/10.7573/dic.2020-2-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233296PMC

Multi-modal radiomics model to predict treatment response to neoadjuvant chemotherapy for locally advanced rectal cancer.

World J Gastroenterol 2020 May;26(19):2388-2402

Department of Gastrointestinal Surgery, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China.

Background: Neoadjuvant chemotherapy is currently recommended as preoperative treatment for locally advanced rectal cancer (LARC); however, evaluation of treatment response to neoadjuvant chemotherapy is still challenging.

Aim: To create a multi-modal radiomics model to assess therapeutic response after neoadjuvant chemotherapy for LARC.

Methods: This retrospective study consecutively included 118 patients with LARC who underwent both computed tomography (CT) and magnetic resonance imaging (MRI) before neoadjuvant chemotherapy between October 2016 and June 2019. Read More

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http://dx.doi.org/10.3748/wjg.v26.i19.2388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243642PMC

Impact of a standardized reporting format on the quality of MRI reports for rectal cancer staging.

Indian J Radiol Imaging 2020 Jan-Mar;30(1):7-12. Epub 2020 Mar 30.

Department of Radio Diagnosis, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Background And Aims: Besides providing a surgical roadmap, rectal MRI plays a major role in treatment planning. We recently started using a structured template for reporting rectal cancer via MRI. We study the impact of using this template at our hospital in terms of number of essential imaging parameters described in the reports as compared to the pre-template free-text reports. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_308_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240900PMC

Evaluation of variation of interfraction doses to organs at risk during brachytherapy of cervical cancer.

Med J Armed Forces India 2020 Apr 3;76(2):201-206. Epub 2019 May 3.

Senior Advisor (Radiology), INHS Asvini, Colaba, Mumbai 400005, India.

Background: Two-dimensional treatment planning using radiographs or simulator films was the standard in planning brachytherapy for patients with cervical cancer. Three-dimensional (3D) treatment planning has improved treatment efficacy. This retrospective study compares conventional and 3D treatment planning of brachytherapy in patients with cervical cancer and interfraction dose variation to bladder and rectum (D2cc). Read More

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http://dx.doi.org/10.1016/j.mjafi.2019.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244865PMC

Trends in cancer incidence in Uruguay: 2002 -2015.

Colomb Med (Cali) 2019 Dec 30;50(4):224-238. Epub 2019 Dec 30.

Universidad de la República, Facultad de Medicina, Departamento de Métodos Cuantitativos. Montevideo, Uruguay.

Background: Uruguay is the south American country which has the highest cancer incidence and mortality rates. The National Cancer Registry collects data on cancer cases nationwide since 1989 and has reached high quality standards in the last decades. This is the first report on incidence trends. Read More

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http://dx.doi.org/10.25100/cm.v50i4.4212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232944PMC
December 2019

A systematic review of the role of carbon ion radiation therapy in recurrent rectal cancer.

Acta Oncol 2020 Jun 1:1-6. Epub 2020 Jun 1.

Department of Radiation Oncology, Mayo Clinic Florida, Jacksonville, FL, USA.

Colorectal cancer is the fourth leading cause of cancer-associated death in the world. The 5-year local recurrence rates in patients undergoing multimodality therapy are approximately 5-10%. The standard approach to treat locally recurrent rectal is re-irradiation followed by surgical resection. Read More

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http://dx.doi.org/10.1080/0284186X.2020.1769184DOI Listing

MRI-based radiomics nomogram to predict synchronous liver metastasis in primary rectal cancer patients.

Cancer Med 2020 May 31. Epub 2020 May 31.

Department of Radiology, Changhai Hospital, Shanghai, China.

At the time of diagnosis, approximately 15%-20% of patients with rectal cancer (RC) presented synchronous liver metastasis (SLM), which is the most common cause of death in patients with RC. Therefore, preoperative, noninvasive, and accurate prediction of SLM is crucial for personalized treatment strategies. Recently, radiomics has been considered as an advanced image analysis method to evaluate the neoplastic heterogeneity with respect to diagnosis of the tumor and prediction of prognosis. Read More

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http://dx.doi.org/10.1002/cam4.3185DOI Listing

Initial experience with SelectMDx® in the diagnosis of prostate cancer in a real-world evidence clinical practice setting.

Actas Urol Esp 2020 May 28. Epub 2020 May 28.

Instituto Lyx Urología. Universidad Francisco de Vitoria, Madrid, España; Servicio de Urología, Hospital Universitario Puerta de Hierro-Majadahonda. Universidad Autónoma de Madrid, Madrid, España.

Introduction: The use of biomarkers in the detection of prostate cancer (PC) can decrease overdiagnosis and overtreatment of non-significant PC. We analyze the usefulness and applicability of the SelectMDx® marker in a routine clinical practice setting.

Material And Methods: Retrospective study of 48 patients evaluated by the SelectMDx® test between July 2017 and April 2019. Read More

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http://dx.doi.org/10.1016/j.acuro.2020.03.005DOI Listing

Peri-prostatic adipose tissue measurements using MRI predict prostate cancer aggressiveness in men undergoing radical prostatectomy.

J Endocrinol Invest 2020 May 30. Epub 2020 May 30.

Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301, Middle Yan-Chang Rd., Jing-An District, Shanghai, 200072, China.

Objectives: To evaluate the effect of peri-prostatic adipose tissue (PPAT) measurements using preoperative MRI on the prediction of prostate cancer (PCa) aggressiveness in men undergoing radical prostatectomy (RP).

Methods: We performed a retrospective study on 179 consecutive patients receiving RP from June 2016 to October 2018. Clinical characteristics were collected. Read More

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http://dx.doi.org/10.1007/s40618-020-01294-6DOI Listing

Predictive factors of complete pathological response in patients with locally advanced rectal cancer.

Int J Colorectal Dis 2020 May 30. Epub 2020 May 30.

Cabrini Monash University Department of Surgery, Cabrini Health, Malvern, VIC, 3144, Australia.

Purpose: Patients with locally advanced rectal cancer who achieve pathologic complete response (pCR) following neoadjuvant therapy have better long-term outcomes and could be spared from the perioperative and long-term morbidity of rectal resection. The aim of this study was to identify factors that predict the ability to achieve pCR at completion of conventional neoadjuvant therapy, therefore determining their suitability for non-surgical management.

Methods: A retrospective analysis was performed on data obtained from a prospectively maintained colorectal neoplasia database. Read More

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http://dx.doi.org/10.1007/s00384-020-03633-8DOI Listing

Development and evaluation of a patient-centred program for low anterior resection syndrome: protocol for a randomized controlled trial.

BMJ Open 2020 May 30;10(5):e035587. Epub 2020 May 30.

Division of Colon and Rectal Surgery, Jewish General Hospital, Montreal, Quebec, Canada

Introduction: Low anterior resection syndrome (LARS) is described as disordered bowel function after rectal resection that leads to a detriment in quality of life, and affects the majority of individuals following restorative proctectomy for rectal cancer. The management of LARS includes personalised troubleshooting and effective self-management behaviours. Thus, affected individuals need to be well informed and appropriately engaged in their own LARS management. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-035587DOI Listing

Ileorectal Anastomosis versus Ileal Pouch-Anal Anastomosis for the Surgical Treatment of Ulcerative Colitis: A Markov Decision Analysis.

Dis Colon Rectum 2020 May 25. Epub 2020 May 25.

Background: Ileorectal anastomosis in patients with ulcerative colitis results in decreased postoperative morbidity and better functional outcome but leads to increased risk for rectal cancer compared to ileal pouch-anal anastomosis.

Objective: To compare ileorectal anastomosis with ileal pouch-anal anastomosis in ulcerative colitis, using a decision model.

Design: A Markov simulation model was designed to simulate clinical events of ileorectal anastomosis and ileal pouch-anal anastomosis over a time horizon of 40 years with time cycles of 1 year. Read More

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http://dx.doi.org/10.1097/DCR.0000000000001686DOI Listing

ASO Author Reflections: Challenges in the Management of Synchronous Prostate Cancer and Rectal Cancer: Towards Double Organ Preservation?

Ann Surg Oncol 2020 May 29. Epub 2020 May 29.

Department of Digestive Surgical Oncology - Liver Transplantation Unit, University Hospital of Besançon, Besançon, France.

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http://dx.doi.org/10.1245/s10434-020-08685-2DOI Listing

Robotic extralevator abdominoperineal resection with en bloc multivisceral resection and lateral lymph node dissection for rectal cancer.

Tech Coloproctol 2020 May 30. Epub 2020 May 30.

Department of Gastroenterological Surgery, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto-ku, Tokyo, 135-8550, Japan.

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http://dx.doi.org/10.1007/s10151-020-02256-zDOI Listing

Results of laparoscopic resection in high-risk rectal cancer patients.

Langenbecks Arch Surg 2020 May 29. Epub 2020 May 29.

University of Portsmouth, School of Health and Care Professions, St Andrews Court, St Michael's road, Portsmouth, PO1 2PR, UK.

Purpose: Obesity, neoadjuvant-radiotherapy, tumour proximity to the anal verge and previous abdominal surgery are factors that might increase the intra-operative difficulty of laparoscopic rectal cancer surgery. However, whether patients with these 'high-risk' characteristics are subject to worse short- or long-term outcomes is debated. The aim of this study is to examine the short- and long-term clinical and oncological outcomes of patients receiving laparoscopic rectal surgery with any of these high-risk characteristics and compare them with patients that do not possess any of these high-risk features. Read More

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http://dx.doi.org/10.1007/s00423-020-01892-1DOI Listing

NORAD01-GRECCAR16 multicenter phase III non-inferiority randomized trial comparing preoperative modified FOLFIRINOX without irradiation to radiochemotherapy for resectable locally advanced rectal cancer (intergroup FRENCH-GRECCAR- PRODIGE trial).

BMC Cancer 2020 May 29;20(1):485. Epub 2020 May 29.

Service de Chirurgie Digestive et Oncologique, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Sud, Assistance Publique, Hôpitaux de Paris, 63, rue Gabriel Péri, Le Kremlin Bicetre, 94275, France.

Background: Preoperative radiochemotherapy (RCT) is recommended in France prior to total mesorectal excision in patients with mid or low locally advanced rectal cancer (LARC) (cT3/T4 and/or N+) because it has been shown to improve local control. Preoperative RCT has also disadvantages including the absence of proven impact on metastatic recurrence and the risk of late side effects on bowel and genitourinary function. In patients with primarily resectable LARC, preoperative systemic chemotherapy without pelvic irradiation could be used as an alternative to RCT. Read More

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http://dx.doi.org/10.1186/s12885-020-06968-1DOI Listing

A new aortoiliac calcification scoring system to predict grade C anastomotic leak following rectal cancer surgery.

Tech Coloproctol 2020 May 28. Epub 2020 May 28.

Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, 322 Seoyang-ro Hwasun-eup, Hwasun-gun, Jeonnam, 58128, South Korea.

Background: Aortoiliac calcification may be a surrogate marker of decreased visceral perfusion causing anastomotic leak (AL). The aim of this study was to evaluate the predictive role of aortoiliac calcification for AL after rectal cancer surgery.

Methods: We enrolled patients with primary rectal cancer who had restorative resection at our institution between January 2013 and December 2015. Read More

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http://dx.doi.org/10.1007/s10151-020-02246-1DOI Listing

High expression of immune checkpoints is associated with the TIL load, mutation rate and patient survival in colorectal cancer.

Int J Oncol 2020 May 8. Epub 2020 May 8.

College of Medicine, Member of QU Health, Qatar University, P.O. Box 2713 Doha, Qatar.

Adoptive cell therapy with the use of tumor-infiltrating lymphocytes (TILs) is a very promising immunotherapeutic approach for the treatment of patients with colorectal cancer (CRC). However, within the tumor microenvironment, co‑inhibitory immune checkpoints can inactivate TILs. The aim of the present study was to examine the association between the TIL load, the mutation rate and the clinical outcome in the immune landscape of patients with CRC. Read More

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http://dx.doi.org/10.3892/ijo.2020.5062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252459PMC

Association between Abdominal Obesity and Incident Colorectal Cancer: A Nationwide Cohort Study in Korea.

Cancers (Basel) 2020 May 26;12(6). Epub 2020 May 26.

Department of Surgery, College of Medicine, Korea University, Seoul 02841, Korea.

Background: We investigated the association of waist circumference (WC) and abdominal obesity with the incident colorectal cancer risk in Korean adults.

Methods: This nationwide population-based cohort study was based on health insurance claims data. We analyzed data from 9,959,605 participants acquired through health check-ups of the Korean National Health Insurance Service in 2009 who were followed up until the end of 2017. Read More

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http://dx.doi.org/10.3390/cancers12061368DOI Listing

ADAPTIVE STRATEGY FOR EXTERNAL BEAM RADIOTHERAPY IN PROSTATE CANCER: MANAGEMENT OF THE GEOMETRICAL UNCERTAINTIES WITH ROBUST OPTIMIZATION.

Pract Radiat Oncol 2020 May 25. Epub 2020 May 25.

Division of Radiotherapy, University Hospital "Maggiore della Carità", corso Mazzini 18, 28100 Novara, Italy; Department of Translational Medicine, University of Piemonte Orientale (UPO), via Solaroli 17, 28100 Novara, Italy. Electronic address:

Objective: We aim to develop and validate a new adaptive method (O-ART) for prostate cancer (PCa) radiotherapy (RT), using an off-line strategy to improve treatment personalization by modelling the internal target volume (ITV) on individual basis and account for the residual set-up uncertainties by robust optimization.

Methods And Materials: 20 patients with intermediate-high PCa treated with radical RT were enrolled. The first step of the O-ART strategy is the identification of a patient specific ITV based on the KV-cone beam CT (kV-CBCT) datasets acquired during the first five fractions. Read More

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http://dx.doi.org/10.1016/j.prro.2020.05.006DOI Listing

Delayed coloanal anastomosis: an alternative option for restorative rectal cancer surgery after high-dose pelvic radiotherapy for prostate cancer.

Colorectal Dis 2020 May 28. Epub 2020 May 28.

CHU de Bordeaux, Haut-Lévêque Hospital, Department of Digestive Surgery, Pessac, 33604, France.

Aim: Restorative total mesorectal excision (TME) for rectal cancer after high-dose pelvic radiotherapy for prostate cancer has been reported to provide a non-acceptable pelvic sepsis rate. We proposed in a previous publication to perform a delayed coloanal anastomosis (DCAA) in this situation. This study aimed to assess feasibility and outcomes of this strategy. Read More

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http://dx.doi.org/10.1111/codi.15144DOI Listing

Preoperative radiotherapy for locally advanced rectal cancer during and after the COVID-19 pandemic.

Br J Surg 2020 May 28. Epub 2020 May 28.

Radiotherapy Department, Mount Vernon Centre for Cancer Treatment, Mount Vernon Hospital, Northwood, UK.

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http://dx.doi.org/10.1002/bjs.11725DOI Listing

Dietary Total Antioxidant Capacity (TAC) Significantly Reduces the Risk of Site-Specific Cancers: An Updated Systematic Review and Meta-Analysis.

Nutr Cancer 2020 May 28:1-19. Epub 2020 May 28.

Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

We aimed to evaluate the possible role of dietray TAC against different types of cancers in a systematic review and meta-analyses of observational studies. A literature search of authentic electronic resources had been performed to obtain the relevant studies up to February 2020. Twenty-one studies including nine prospective and twelve case-control studies were included in the current systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1080/01635581.2020.1771385DOI Listing

First cases of combined full robotic partial nephrectomy and colorectal resections: results and new perspectives.

Int J Med Robot 2020 May 27:e2131. Epub 2020 May 27.

Department of Urology, Baggiovara General Hospital, University of Modena and Reggio Emilia, Modena, Italy.

Background: Nowadays robotic platform is widespread in general surgery, urology and gynecology. Combined surgery may represent an alternative to sequential procedures and it allow the treatment, at the same time, of coexisting lesions; in this perspective, full-robotic multiorgan surgery is starting to gain interest from surgeons worldwide.

Methods: Between April and June 2019, two patients presenting with synchronous colorectal and kidney cancers underwent respectively full-robotic right colectomy with right partial nephrectomy and anterior rectal resection with left partial nephrectomy. Read More

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http://dx.doi.org/10.1002/rcs.2131DOI Listing