66,093 results match your criteria Rectal Cancer


Factors influencing changing bowel habits in patients undergoing sphincter-saving surgery for rectal cancer.

Int Wound J 2019 Mar;16 Suppl 1:71-75

Department of Clinical Nursing, University of Ulsan, Seoul, South Korea.

A research survey research was conducted to identify factors affecting changes in bowel habits of rectal cancer patients undergoing sphincter-saving surgery and to provide basic information useful in nursing interventions supporting treatment for rectal cancer patients. The subjects were rectal cancer patients who had undergone sphincter-saving surgery over 2 years ago. The final analysis included 107 patients who had made outpatient visits to the colorectal surgery from 12th to 31st May, 2014. Read More

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http://dx.doi.org/10.1111/iwj.13060DOI Listing

Significance of MRI in rectal carcinoma therapy optimization - correlation of preoperative T- and N-staging with definitive histopathological findings.

Neoplasma 2019 Feb 17;2019. Epub 2019 Feb 17.

3rd Surgical Clinic, Faculty of Medicine, Comenius University, Bratislava, Slovakia.

In past decades, both prognosis and therapy of rectal cancer patients showed significant improvement, on the other hand, the incidence of rectal carcinoma continues to have a rising tendency. According to current UICC classification, patients in stage II rectal cancer or higher are indicated for neoadjuvant chemoradiotherapy (nCRT). Magnetic resonance imaging (MRI) is currently the most common diagnostic method used for preoperative staging of rectal cancer. Read More

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http://dx.doi.org/10.4149/neo_2018_180522N334DOI Listing
February 2019

Predictive values of colorectal cancer alarm symptoms in the general population: a nationwide cohort study.

Br J Cancer 2019 Feb 22. Epub 2019 Feb 22.

Research Unit of General Practice, Department of Public Health, University of Southern Denmark, J. B. Winsløws Vej 9A, 5000, Odense C, Denmark.

Background: Alarm symptoms are used in many cancer referral guidelines. The objectives were to determine the 1-year predictive values (PVs) of colorectal cancer (CRC) alarm symptoms in the general population and to describe the proportion of alarm symptoms reported prior to diagnosis.

Methods: A nationwide prospective cohort of 69,060 individuals ≥40 years randomly selected from the Danish population was invited to complete a survey regarding symptoms and healthcare-seeking in 2012. Read More

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http://dx.doi.org/10.1038/s41416-019-0385-xDOI Listing
February 2019

Pattern, Stage, and Time of Recurrent Colorectal Cancer After Curative Surgery.

Clin Colorectal Cancer 2019 Jan 29. Epub 2019 Jan 29.

Head Surgery Unit, Clinical Sciences Department, College of Medicine University of Sharjah, Sharjah, United Arab Emirates. Electronic address:

Surgery remains the mainstay of curative treatment for colorectal cancer (CRC). Despite curative surgery, some patients experience cancer recurrence. However, the pattern, stage, and time of recurrent disease (RD) remain unknown. Read More

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http://dx.doi.org/10.1016/j.clcc.2019.01.003DOI Listing
January 2019

Poor prognostic and staging value of tumor deposit in locally advanced rectal cancer with neoadjuvant chemoradiotherapy.

Cancer Med 2019 Feb 21. Epub 2019 Feb 21.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Tumor deposit (TD) was associated with poor survival in colorectal cancer. However, its prognostic and staging value in locally advanced rectal cancer (LARC) patients following neoadjuvant chemoradiotherapy (neo-CRT) is controversial. Four hundred and ninety-five LARC patients following neo-CRT and surgery were retrospectively analyzed. Read More

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http://dx.doi.org/10.1002/cam4.2034DOI Listing
February 2019

The obesity paradox in beyond total mesorectal excision surgery for locally advanced and recurrent rectal cancer.

Updates Surg 2019 Feb 21. Epub 2019 Feb 21.

Department of Colorectal Surgery, The Royal Marsden Hospital, London, UK.

The objective is to investigate preoperative body mass index (BMI) in patients receiving beyond total mesorectal excision (bTME) surgery. The primary end point is length of postoperative stay. Secondary end points are length of intensive care stay, postoperative morbidity and overall survival. Read More

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http://dx.doi.org/10.1007/s13304-019-00631-6DOI Listing
February 2019

Oncologic outcomes for low rectal adenocarcinoma following low anterior resection with coloanal anastomosis versus abdominoperineal resection: a National Cancer Database propensity matched analysis.

Int J Colorectal Dis 2019 Feb 21. Epub 2019 Feb 21.

Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Purpose: Low anterior resection with coloanal anastomosis (CAA) for low rectal cancer is a technically difficult operation with limited data available on oncologic outcomes. We aim to investigate overall survival and operative oncologic outcomes in patients who underwent CAA compared to abdominoperineal resection (APR).

Methods: The National Cancer Database (2004-2013) was used to identify patients with non-metastatic rectal adenocarcinoma who underwent CAA or APR. Read More

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http://dx.doi.org/10.1007/s00384-019-03267-5DOI Listing
February 2019

Accuracy of Physical Examination, Transvaginal Sonography, Magnetic Resonance Imaging, and Rectal Endoscopic Sonography for Preoperative Evaluation of Rectovaginal Endometriosis.

Ultrasound Q 2019 Feb 16. Epub 2019 Feb 16.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University.

The aim of this study was to compare the effectiveness of physical examination, transvaginal sonography, magnetic resonance imaging, and rectal endoscopic sonography for the identification of rectovaginal endometriosis and potential rectal infiltration. Women with suspected rectovaginal endometriosis underwent physical examination, transvaginal sonography, magnetic resonance imaging, and rectal endoscopic sonography. Evaluation was performed for the presence of rectovaginal endometriotic foci and rectal infiltration. Read More

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http://dx.doi.org/10.1097/RUQ.0000000000000428DOI Listing
February 2019

Adjuvant radiotherapy after local excision of rectal cancer.

Acta Oncol 2019 Feb 21:1-5. Epub 2019 Feb 21.

a Department of Colorectal Surgery , Oxford University Hospitals , Oxford , UK.

Background: Local excision is now accepted as a standard treatment option for certain patients with early rectal cancer. However, there is a higher risk of local recurrence than after radical surgery with total mesorectal excision. Adjuvant radiotherapy after local excision may reduce this excess risk, and yet retain the benefits of local excision, with rectal preservation. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1578895DOI Listing
February 2019

Combined robotic and transanal total mesorectal excision with hysterectomy for rectal cancer.

Tech Coloproctol 2019 Feb 20. Epub 2019 Feb 20.

Department of Gastrointestinal Surgery, Hospital Clinic, Villarroel, 170, 08036, Barcelona, Spain.

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http://dx.doi.org/10.1007/s10151-019-01939-6DOI Listing
February 2019

Rectal cancer DFP dedicated issue: abdominal radiology : The role of ERUS in staging of primary rectal cancer: a surgeon's perspective.

Authors:
P Terry Phang

Abdom Radiol (NY) 2019 Feb 20. Epub 2019 Feb 20.

University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s00261-019-01949-wDOI Listing
February 2019

Palmar-plantar Erythrodysesthesia with Genital Involvement Secondary to Capecitabine Chemoradiotherapy: A Case Report.

Cureus 2018 Dec 8;10(12):e3704. Epub 2018 Dec 8.

Radiation Oncology, London Regional Cancer Program, Western University, London, CAN.

Palmar-plantar erythrodysesthesia (PPE) is a common dermatologic adverse reaction secondary to capecitabine use, but the skin toxicity rarely involves the genitals. We describe a case of PPE with scrotal and penile involvement secondary to capecitabine chemotherapy concurrent with radiotherapy. The patient presented with pain and erythema involving the penis and scrotum during the fifth week of neoadjuvant chemoradiotherapy with capecitabine for T3c N2b M0 low rectal adenocarcinoma. Read More

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http://dx.doi.org/10.7759/cureus.3704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373891PMC
December 2018

Lower lymph node yield following neoadjuvant therapy for rectal cancer has no clinical significance.

J Gastrointest Oncol 2019 Feb;10(1):42-47

Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore.

Background: Obtaining 12 lymph nodes following resection for rectal cancer is an important prognostic marker. However, patients who have received neoadjuvant therapy are known to have a lower lymph node yield. We conducted this study to determine the clinical significance of evaluating <12 versus ≥12 lymph nodes in individuals who underwent surgery following neoadjuvant therapy for rectal cancer. Read More

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http://dx.doi.org/10.21037/jgo.2018.10.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351311PMC
February 2019

Low prevalence of deficient mismatch repair (dMMR) protein in locally advanced rectal cancers (LARC) and treatment outcomes.

J Gastrointest Oncol 2019 Feb;10(1):19-29

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India.

Background: The available evidence in locally advanced rectal cancer (LARC) suggests a low prevalence of deficient mismatch repair (dMMR) protein status, approximating 1-3%.

Methods: Patients with LARC who were offered long course chemoradiation (LCRT), as per institution protocol during the period of 1st January 2014 to 31st December 2015 at Tata Memorial Hospital (TMH) in Mumbai were evaluated for outcomes and assessment of MMR status.

Results: A total of 419 patients were evaluated for LARC in TMH, of whom 354 were treated with LCRT. Read More

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http://dx.doi.org/10.21037/jgo.2018.10.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351294PMC
February 2019

Recommendation of long-term and systemic management according to the risk factors in rectal NETs patients.

Sci Rep 2019 Feb 20;9(1):2404. Epub 2019 Feb 20.

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

Rectal neuroendocrine tumors (NETs) are often found as small lesions, which can be treated by endoscopic resection. However, high risk cases with lymph node (LN) metastasis are indication of radical surgery. Furthermore, rectal NETs are often associated with late recurrences and/or multiple cancer development. Read More

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http://dx.doi.org/10.1038/s41598-018-37707-zDOI Listing
February 2019

Association of genetic ancestry with colorectal tumor location in Puerto Rican Latinos.

Hum Genomics 2019 Feb 20;13(1):12. Epub 2019 Feb 20.

Division of Cancer Biology, University of Puerto Rico Comprehensive Cancer Center, PMB 711 Ave. De Diego 89 Ste. 105, San Juan, PR, 00927-6346, USA.

Background: Colorectal cancer (CRC) is the first cause of cancer deaths among Puerto Ricans. The incidence and mortality of CRC in Puerto Rico continue to be on the rise. The burden of CRC in Puerto Rico is higher than among US Hispanics and is second only to African Americans, thus supporting the importance of studying this CRC health disparity. Read More

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http://dx.doi.org/10.1186/s40246-019-0196-4DOI Listing
February 2019

[Complications of transperineal template-guided prostate mapping biopsy].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):428-431

Department of Urology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China.

To assess the complications of transperineal template-guided prostate mapping biopsy (TTMB). Between May 2017 and March 2018, 142 consecutive patients with prior negative transrectal biopsy results and persistently elevated prostate-specific antigen (PSA) were divided into the observation group and the control group randomly. The observation group underwent TTMB and the control group underwent transperineal template-guided prostate saturation biopsy (TTSB). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.009DOI Listing
February 2019

Evaluation of Access to Hospitals Most Ready to Achieve National Accreditation for Rectal Cancer Treatment.

JAMA Surg 2019 Feb 20. Epub 2019 Feb 20.

Center for Healthcare Outcomes and Policy, University of Michigan, Ann Arbor.

Importance: The American College of Surgeons National Accreditation Program for Rectal Cancer (NAPRC) promotes multidisciplinary care to improve oncologic outcomes in rectal cancer. However, accreditation requirements may be difficult to achieve for the lowest-performing institutions. Thus, it is unknown whether the NAPRC will motivate care improvement in these settings or widen disparities. Read More

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http://dx.doi.org/10.1001/jamasurg.2018.5521DOI Listing
February 2019

The clinical significance of a pathologically positive lymph node at the circumferential resection margin in rectal cancer.

Tech Coloproctol 2019 Feb 19. Epub 2019 Feb 19.

Department of Colorectal Surgery, Good Hope Hospital, Heart of England NHS Foundation Trust, Rectory Road, Sutton Coldfield, Birmingham, B75 7RR, UK.

Background: This study aimed to determine if the nature of circumferential resection margin (CRM) involvement, either by tumour or lymph nodes, had an impact upon local recurrence and survival in rectal cancer.

Methods: A retrospective analysis of a prospectively collected database was performed. Consecutive patients with stage I-III rectal cancer having curative surgery were included. Read More

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http://dx.doi.org/10.1007/s10151-019-01947-6DOI Listing
February 2019

Effect of oxaliplatin combined with 5-fluorouracil on treatment efficacy of radiotherapy in the treatment of elderly patients with rectal cancer.

Exp Ther Med 2019 Mar 20;17(3):1517-1522. Epub 2018 Dec 20.

Department of Tumor Radiotherapy, Laigang Hospital Affiliated to Taishan Medical University, Laiwu, Shandong 271100, P.R. China.

Efficacy of the combination of oxaliplatin, 5-fluorouracil and radiotherapy on rectal cancer in elderly patients was investigated. Seventy-three elderly patients with rectal cancer confirmed by histopathological examination were randomly divided into 3 groups: oxaliplatin group (25 cases): intravenous infusion of oxaliplatin; fluorouracil group (24 cases): intravenous infusion of fluorouracil; combination group (24 cases), intravenous infusion of oxaliplatin and fluorouracil. All patients were treated with radiotherapy, and efficacy and safety were evaluated after 2 courses of treatment. Read More

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http://dx.doi.org/10.3892/etm.2018.7119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364248PMC
March 2019
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Safety of temporary ileostomy via specimen extraction site in rectal cancer patients who underwent laparoscopic low anterior resection.

Sci Rep 2019 Feb 19;9(1):2316. Epub 2019 Feb 19.

Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.

If anastomotic site leakage is expected after laparoscopic low anterior resection (LAR), de-functioning ileostomy is required. However, there is controversy about the consequence of stoma formation via the specimen extraction site (SES). Therefore, we aimed to investigate stoma-related complication according to stoma formation via the SES. Read More

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http://dx.doi.org/10.1038/s41598-019-38790-6DOI Listing
February 2019

Does Interfraction Cone Beam Computed Tomography Improve Target Localization in Prostate Bed Radiotherapy?

Technol Cancer Res Treat 2019 Jan;18:1533033819831962

1 McGill University, Jewish General Hospital, Montreal, Quebec, Canada.

Purpose:: In this prospective phase II study, we investigated whether cone beam computed tomography scan was a superior method of image-guided radiotherapy relative to 2D orthogonal kilovoltage images in the post-radical prostatectomy setting.

Methods:: A total of 419 treatment fractions were included in this analysis. The shifts required to align the patient for each treatment were performed using 3D matching between cone beam computed tomography scans and the corresponding computed tomography images used for planning. Read More

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http://dx.doi.org/10.1177/1533033819831962DOI Listing
January 2019

Implementation of High Dose-rate Brachytherapy for Cervix Cancer in a Low-income Country.

Ann Glob Health 2018 Nov 5;84(4):679-682. Epub 2018 Nov 5.

Department of Radiation Oncology, University of Florida, US.

Background: The purpose of this study is to detail the implementation of HDR brachytherapy at the only radiotherapy center in Nicaragua.

Methods: Patients are treated with external-beam radiotherapy to 46-50Gy at 2Gy/fraction to the pelvis. A gynecologic examination is performed weekly. Read More

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http://dx.doi.org/10.9204/aogh.2377DOI Listing
November 2018

The radiation oncologist point of view on "Predictive value of 18F-FDG PET/CT on survival in locally advanced rectal cancer after neoadjuvant chemoradiation".

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):903-905

Department of Radiation Oncology, Azienda Sanitaria Universitaria Integrata UD, Udine, Italy.

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http://dx.doi.org/10.26355/eurrev_201902_16970DOI Listing
February 2019

Utilising taTME and robotics to reduce R1 risk in locally advanced rectal cancer with rectovaginal and cervical involvement.

Tech Coloproctol 2019 Feb 16. Epub 2019 Feb 16.

Division of Cancer Surgery, Victorian Comprehensive Cancer Centre, Melbourne, Australia.

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http://dx.doi.org/10.1007/s10151-019-01941-yDOI Listing
February 2019

The effect of increased body mass index values on surgical outcomes after radical resection for low rectal cancer.

Surg Today 2019 Feb 18. Epub 2019 Feb 18.

Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Guo Xue Xiang No. 37, Chengdu, 610041, China.

Purposes: This study aimed to explore the effect of increased body mass index (BMI) values (overweight: BMI ≥ 25-30 kg/m; obese: BMI ≥ 30 kg/m) on surgical outcomes after radical resection for low rectal cancer (LRC).

Methods: Patients with LRC who underwent radical surgery from January 2009 to December 2013 were included. The patients were divided into three groups according to their BMI values (control group: BMI < 25 kg/m; overweight group: BMI 25 to < 30 kg/m; obese group: BMI ≥ 30 kg/m). Read More

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http://dx.doi.org/10.1007/s00595-019-01778-wDOI Listing
February 2019

Surgical treatment of rectal cancer with a Retzius shunt: a case report.

Surg Case Rep 2019 Feb 18;5(1):25. Epub 2019 Feb 18.

Department of Surgery, Osaka Rosai Hospital, 1179-3 Nagasonecho, Kita-ku, Sakai, 591-8025, Japan.

Background: A case of a short circuit (Retzius shunt) from the inferior mesenteric vein (IMV) to the inferior vena cava (IVC) without accompanying portal hypertension due to liver cirrhosis is rare.

Case Presentation: An 83-year-old woman who was followed after surgery for thyroid and breast cancer was incidentally found to have rectal cancer on computed tomography (CT). Preoperative three-dimensional CT showed a venous malformation forming a short circuit (Retzius shunt) from the IMV to the IVC. Read More

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http://dx.doi.org/10.1186/s40792-019-0583-zDOI Listing
February 2019

Laparoscopic and open resection of rectal cancer-is age an effect modifier for short- and long-term survival?

Int J Colorectal Dis 2019 Feb 18. Epub 2019 Feb 18.

Klinik für Allgemein-, Viszeral-, Thoraxchirurgie und Adipositasmedizin, Caritas Krankenhaus St. Josef Regensburg, Landshuter Str. 65, 93053, Regensburg, Germany.

Introduction: Rectal cancer is a frequently diagnosed tumor worldwide. Various studies have shown the noninferiority or even slight superiority of laparoscopic resection. However, there is no clear recommendation on whether age should influence the choice of surgical approach. Read More

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http://dx.doi.org/10.1007/s00384-019-03265-7DOI Listing
February 2019

Combining urinary DNA methylation and cell-free microRNA biomarkers for improved monitoring of prostate cancer patients on active surveillance.

Urol Oncol 2019 Feb 15. Epub 2019 Feb 15.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada; Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Purpose: Prostate cancer (CaP) patients with low-grade tumors are enrolled in active surveillance (AS) programs and monitored with digital rectal exams (DREs), prostate-specific antigen (PSA) tests, and periodic invasive biopsies. Patients are "reclassified" with higher-risk disease if they show signs of disease progression. However, AS patients who will reclassify cannot be easily identified upfront and suffer morbidities associated with biopsy. Read More

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http://dx.doi.org/10.1016/j.urolonc.2019.01.031DOI Listing
February 2019

Population-based study of surgical treatment with and without tumour resection in patients with locally recurrent rectal cancer.

Br J Surg 2019 Feb 18. Epub 2019 Feb 18.

Department of Molecular Medicine and Surgery, Karolinska Institutet and Center of Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.

Background: Population-based studies of treatment of locally recurrent rectal cancer (LRRC) are lacking. The aim was to investigate the surgical treatment of patients with LRRC at a national population-based level.

Methods: All patients undergoing abdominal resection for primary rectal cancer between 1995 and 2002 in Sweden with LRRC as a first event were included. Read More

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http://dx.doi.org/10.1002/bjs.11098DOI Listing
February 2019

A 3D-Printed Patient-Specific Phantom for External Beam Radiation Therapy of Prostate Cancer.

J Eng Sci Med Diagn Ther 2018 Nov 6;1(4). Epub 2018 Aug 6.

Department of Radiology, Boston Medical Center & Boston University School of Medicine, 820 Harrison Ave., Boston, MA 02118.

This paper presents the design evolution, fabrication, and testing of a novel patient and organ-specific, 3D printed phantom for external beam radiation therapy of prostate cancer. In contrast to those found in current practice, this phantom can be used to plan and validate treatment tailored to an individual patient. It contains a model of the prostate gland with a dominant intraprostatic lesion, seminal vesicles, urethra, ejaculatory duct, neurovascular bundles, rectal wall, and penile bulb generated from a series of combined T2-weighted/dynamic contrast-enhanced magnetic resonance images. Read More

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http://dx.doi.org/10.1115/1.4040817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376205PMC
November 2018

Modeling of Acute Rectal Toxicity to Compare Two Patient Positioning Methods for Prostate Cancer Radiotherapy: Can Toxicity Modeling be Used for Quality Assurance?

OMICS J Radiol 2018 3;7(5). Epub 2018 Dec 3.

Department of Radiation Oncology, Mayo Clinic Arizona, USA.

Purpose: Intensity Modulated Radiation Therapy (IMRT) allows for significant dose reductions to organs at risk in prostate cancer patients. However, the accurate delivery of IMRT plans can be compromised by patient positioning errors. The purpose of this study was to determine if the modeling of grade ≥ 2 acute rectal toxicity could be used to monitor the quality of IMRT protocols. Read More

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http://dx.doi.org/10.4172/2167-7964.1000302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376967PMC
December 2018

The controversy of neoadjuvant therapy in rectal cancer.

Cir Esp 2019 Feb 14. Epub 2019 Feb 14.

Gastrointestinal and Pancreatic Oncology Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, España.

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http://dx.doi.org/10.1016/j.ciresp.2019.01.004DOI Listing
February 2019

Lymphocyte nadir predicts tumor response and survival in locally advanced rectal cancer after neoadjuvant chemoradiotherapy: Immunologic relevance.

Radiother Oncol 2019 Feb 31;131:52-59. Epub 2018 Dec 31.

Department of Radiation Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China. Electronic address:

Background And Purpose: Neoadjuvant chemoradiation (nCRT) could reduce tumor infiltrating lymphocytes. We examined absolute lymphocyte count (ALC) nadir during nCRT, pathologic response and prognosis for locally advanced rectal cancer (LARC).

Materials And Methods: 102 patients with LARC (cT3-4N0, or node-positive) treated between 2010 and 2015 with nCRT followed by complete resection were analyzed. Read More

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http://dx.doi.org/10.1016/j.radonc.2018.12.001DOI Listing
February 2019

Reply letter to: "Lymph node harvest in rectal cancer patients with good tumour regression grade following neoadjuvant chemoradiotherapy".

Int J Surg 2019 Feb 14. Epub 2019 Feb 14.

Department of Gastroenterology, Surgical Division, University of Sao Paulo, Medical School, Sao Paulo, Brazil.

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http://dx.doi.org/10.1016/j.ijsu.2019.02.009DOI Listing
February 2019

Complementary relation between the improvement of dose delivery technique and PTV margin reduction in dose-escalated radiation therapy for prostate cancer.

Pract Radiat Oncol 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiation Oncology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510 Japan.

Purpose: The purpose of this work is to demonstrate quantitatively the complementary relation between the introduction of intensity-modulated radiation therapy (IMRT) and planning target volume (PTV) margin reduction with an image-guided technique in reducing the risk of rectal toxicity in dose-escalating prostate radiation therapy.

Methods And Materials: 3D-CRT and IMRT plans were generated for 10 prostate cancer patients based on two PTV margin protocols (10/8 mm and 6/5 mm) and two dose prescriptions (70 Gy and 78 Gy). The normal tissue complication probability (NTCP) for each of eight scenarios was calculated using the Lyman-Kutcher-Burman (LKB) model to estimate the risk of rectal and bladder late toxicity. Read More

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http://dx.doi.org/10.1016/j.prro.2019.02.001DOI Listing
February 2019
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Disqualification of Neoadjuvant Rectal Score Based on Data of 6596 Patients From the Netherlands Cancer Registry.

Clin Colorectal Cancer 2019 Jan 19. Epub 2019 Jan 19.

Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands; Department of Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address:

Background: The neoadjuvant rectal score (NAR) was developed as a surrogate endpoint for overall survival in patients with rectal cancer after neoadjuvant treatment. We aimed to validate the NAR score in patients from the Netherlands Cancer Registry database.

Patients And Methods: We studied patients with rectal cancer treated with long-course neoadjuvant therapy followed by surgery in the Netherlands between 2007 and 2014. Read More

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http://dx.doi.org/10.1016/j.clcc.2019.01.001DOI Listing
January 2019

HER2 as a limited predictor of the therapeutic response to neoadjuvant therapy in locally advanced rectal cancer.

Pathol Res Pract 2019 Jan 28. Epub 2019 Jan 28.

Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Gyeonggi-do 431-070, Republic of Korea.

Human epidermal growth factor 2 (HER2) is a candidate therapeutic and prognostic marker for rectal cancer treated with neoadjuvant chemoradiotherapy. The specific frequency and prognostic role of HER2 protein expression and HER2 gene amplification in those rectal cancers has not been fully investigated. Pretreatment biopsied and surgically resected formalin-fixed paraffin-embedded tissues from 74 patients were retrospectively evaluated for HER2 protein expression and HER2 gene copy number using immunohistochemistry (IHC) and silver in situ hybridization (SISH), respectively. Read More

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http://dx.doi.org/10.1016/j.prp.2019.01.037DOI Listing
January 2019

Trends and Outcomes in Laparoscopic versus Open Surgery for Rectal Cancer from 2005 to 2016 Using the ACS-NSQIP Database, a Retrospective Cohort Study.

Int J Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, Houston Methodist Hospital, Houston, TX, USA; Department of Surgery, The University of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address:

Background: There is controversy regarding the use of laparoscopy for rectal cancer, especially after the ACOSOG Z6051 Randomized Clinical Trial determined that laparoscopy failed to meet non-inferiority compared with open surgery. With these new recommendations, the current practices for the treatment of rectal cancer across the country are unknown.

Methods: Using the ACS-NSQIP database from 2005-2016, resections for rectal cancer were studied. Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.02.006DOI Listing
February 2019

5-Year Outcomes of a Single Institution Prospective Trial of 19 Gy Single-Fraction HDR Brachytherapy for Low- and Intermediate-Risk Prostate Cancer.

Int J Radiat Oncol Biol Phys 2019 Feb 13. Epub 2019 Feb 13.

Department of Radiation Oncology, Beaumont Health System, Royal Oak, MI. Electronic address:

Purpose: To update outcome and toxicity results of a prospective trial of 19 Gy single-fraction high-dose-rate (HDR) brachytherapy for men with low- and intermediate-risk prostate cancer.

Materials And Methods: Patients were treated on a prospective study of single-fraction HDR brachytherapy. All patients had low- or intermediate-risk prostate cancer. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.02.010DOI Listing
February 2019
1 Read

Anticancer and antimetastatic potential of enterolactone: clinical, preclinical and mechanistic perspectives.

Eur J Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Pharmaceutical Sciences, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra 411038, India.

Currently cancer is the second leading cause of death globally and worldwide incidence and mortality rates of all cancers of males and females are rising tremendously. In spite of advances in chemotherapy and radiation, metastasis and recurrence are considered as the major causes of cancer related deaths. Hence there is a mounting need to develop new therapeutic modalities to treat metastasis and recurrence in cancers. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.02.022DOI Listing
February 2019
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A single-center, prospective, randomized clinical trial to investigate the optimal removal time of the urinary catheter after laparoscopic anterior resection of the rectum: study protocol for a randomized controlled trial.

Trials 2019 Feb 15;20(1):133. Epub 2019 Feb 15.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuai Fu Yuan, Dongcheng District, Beijing, 100730, People's Republic of China.

Background: Urinary catheter placement is essential before laparoscopic anterior resection for rectal cancer. Whether early removal of the catheter increases the incidence of urinary retention and urinary tract infection (UTI) is not clear. This study aims to determine the optimal time for removal of the urinary catheter after laparoscopic anterior resection of the rectum. Read More

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https://trialsjournal.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13063-019-3210-1DOI Listing
February 2019
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2.117 Impact Factor

Robotic vs. open cystectomy: How length-of-stay differences relate conditionally to age.

Urol Oncol 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, Mayo Clinic Hospital, Phoenix, AZ. Electronic address:

Objectives: The length-of-stay (LOS) benefit of minimally invasive cystectomy varies in the published literature, potentially because of subgroup effects. Here, we investigated the effect of minimally invasive cystectomy on LOS among different age groups.

Methods And Materials: Adult patients who underwent cystectomy (open or minimally invasive) from January 1, 2012, to December 31, 2016, were identified from the National Surgical Quality Improvement Program database. Read More

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http://dx.doi.org/10.1016/j.urolonc.2019.01.028DOI Listing
February 2019

Postanal minimally invasive surgery "PAMIS" assisted extra-levator abdominoperineal excision "ELAPE" for cancer: A novel approach in supine position.

Authors:
Ahmed Farag

Arab J Gastroenterol 2019 Feb 12. Epub 2019 Feb 12.

Faculty of Medicine, Cairo University, Egypt. Electronic address:

Local recurrences are more common after abdominoperineal excision (APE) than after anterior resection of rectal cancer. Extralevator APE was introduced to address this problem. The post anal minimally invasive approach had been used by other authors for transperineal mesh rectopexy but not in cancer management. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.02.001DOI Listing
February 2019
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Response of locally advanced rectal cancer (LARC) to radiochemotherapy: DW-MRI and multiparametric PET/CT in correlation with histopathology.

Nuklearmedizin 2019 Feb 15;58(1):28-38. Epub 2019 Feb 15.

Lausanne University Hospital, Diagnostic and Interventional Radiology.

Aim: To prospectively evaluate histological significance and predictive value of changes in apparent diffusion coefficient (ADC) and F-FDG PET/CT parameters in locally advanced rectal cancer (LARC) after neoadjuvant radiochemotherapy (RCT).

Methods: Twenty-one patients with untreated LARC underwent pre-RCT and post-RCT F-FDG PET/CT and diffusion-weighted magnetic resonance imaging (DW-MRI), followed by surgery. For both datasets, two readers measured the tumor SUVmax, SUVmean, MTV, TLG, ADCmin, ADCmean, and respective differences (∆SUVmax, ∆SUVmean, ∆MTV, ∆TLG, ∆ADCmin, ∆ADCmean) for the whole tumor. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0809-4670
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http://dx.doi.org/10.1055/a-0809-4670DOI Listing
February 2019
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MRI of Rectal Cancer: Tumor Staging, Imaging Techniques, and Management.

Radiographics 2019 Feb 15:180114. Epub 2019 Feb 15.

From the Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY (N.H., I.P., M.J.G.); Department of Radiology, Hospital Sírio-Libanês, Adma Jafet 91, 01308-050 Bela Vista, São Paulo, Brazil (N.H., B.C.O.); and Department of Radiology, University of São Paulo, São Paulo, Brazil (N.H., C.C.T.R., B.C.O.).

Rectal cancer is prone to local recurrence and systemic metastasis. However, owing to improvements in TNM staging and treatment, including a more widespread use of rectal MRI and increased radiologist awareness of the key rectal cancer TNM staging features, the mortality rate of rectal cancer has been declining over the past few decades in adults over 50 years of age. Currently, rectal MRI plays a key role in the pre- and posttreatment evaluation of rectal cancer, assisting the multidisciplinary team in tailoring the most appropriate treatment option. Read More

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http://dx.doi.org/10.1148/rg.2019180114DOI Listing
February 2019

[Assessment of individualized treatment of rectal carcinoma].

Chirurg 2019 Feb 14. Epub 2019 Feb 14.

Chirurgische Klinik, Campus Virchow-Klinikum und Mitte, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

Individualized and tailored treatment plays a crucial role in the rating of special operation techniques or certain treatment strategies following defined quality criteria and indicators. Deviations from clearly defined recommendations in guidelines must therefore be justified, documented and evaluated as precisely as possible. The aim of this leading article is to examine the individualized treatment of rectal cancer based on existing evidence and to discuss its role in the light of routinely used treatment algorithms. Read More

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http://dx.doi.org/10.1007/s00104-019-0807-6DOI Listing
February 2019