111,151 results match your criteria Rectal Cancer


Laparoscopic transanal minimally invasive surgery (L-TAMIS) versus robotic TAMIS (R-TAMIS): short-term outcomes and costs of a comparative study.

Surg Endosc 2018 Dec 13. Epub 2018 Dec 13.

University of Tennessee Medical Center at Knoxville, 1934 Alcoa Highway, Bldg. D, Ste. 370, Knoxville, TN, 37920, USA.

Background: Transanal minimally invasive surgery (TAMIS) has gained worldwide popularity as a method for the local excision of rectal neoplasms. However, it is technically demanding due to limited working space. Robotic TAMIS offers potential enhanced dexterity and ability while allowing for a more aggressive resection with a stable platform. Read More

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December 2018

Cross-Sectional Study on MRI Restaging After Chemoradiotherapy and Interval to Surgery in Rectal Cancer: Influence on Short- and Long-Term Outcomes.

Ann Surg Oncol 2018 Dec 13. Epub 2018 Dec 13.

Department of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Background: The time interval between CRT and surgery in rectal cancer patients is still the subject of debate. The aim of this study was to first evaluate the nationwide use of restaging magnetic resonance imaging (MRI) and its impact on timing of surgery, and, second, to evaluate the impact of timing of surgery after chemoradiotherapy (CRT) on short- and long-term outcomes.

Methods: Patients were selected from a collaborative rectal cancer research project including 71 Dutch centres, and were subdivided into two groups according to time interval from the start of preoperative CRT to surgery (< 14 and ≥ 14 weeks). Read More

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December 2018

Energy Dispersive X-Ray Fluorescence Zn/Fe Ratiometric Determination of Zinc Levels in Expressed Prostatic Fluid: A Direct, Non-Invasive and Highly Accurate Screening for Prostate Cancer.

Acta Sci Cancer Biol 2018 Nov 10;2(9):20-26. Epub 2018 Oct 10.

The Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Maryland, United States of America.

Prostate specific antigen (PSA) does not provide the reliability that is required for the accurate urology screening of prostate cancer (PCa). Consequently, there has been a major focus and search for a simple, rapid, direct, preferably non-invasive, and highly accurate biomarker and procedure for the urology screening for prostate cancer. Virtually all PCa cases exhibit a marked decrease in zinc in prostate tissue and in prostatic fluid. Read More

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November 2018

Evaluation of prostate-specific antigen density in the diagnosis of prostate cancer combined with magnetic resonance imaging before biopsy in men aged 70 years and older with elevated PSA.

Mol Clin Oncol 2018 Dec 19;9(6):656-660. Epub 2018 Sep 19.

Department of Urology, Keio University School of Medicine, Tokyo 160-8582, Japan.

There is an increasing proportion of individuals aged 70 years and older, as well as an increasing life expectancy worldwide. The present study may guide the management of older patients with elevated prostate specific antigen (PSA). The medical records of 241 older men aged >70 years who underwent multiparametric magnetic resonance imaging (mpMRI) before prostate biopsy (PBx) at our institution were reviewed retrospectively. Read More

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December 2018

Internal Hernia Associated with Colostomy After Laparoscopic Surgery for Rectal Malignancy: A Report of 3 Thought-Provoking Cases.

Am J Case Rep 2018 Dec 14;19:1488-1494. Epub 2018 Dec 14.

Department of Digestive Surgery, Tenri Hospital, Tenri, Nara, Japan.

BACKGROUND Colostomy creation via intraperitoneal route is often performed during laparoscopic Hartmann's operation or abdominoperineal resection (APR). Herein, we report 3 rare cases of internal hernia associated with colostomy (IHAC). CASE REPORT The first case involved a 70-year-old man with IHAC after laparoscopic APR. Read More

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December 2018

Surgical treatment and survival from colorectal cancer in Denmark, England, Norway, and Sweden: a population-based study.

Lancet Oncol 2018 Dec 10. Epub 2018 Dec 10.

Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK.

Background: Survival from colorectal cancer has been shown to be lower in Denmark and England than in comparable high-income countries. We used data from national colorectal cancer registries to assess whether differences in the proportion of patients receiving resectional surgery could contribute to international differences in colorectal cancer survival.

Methods: In this population-based study, we collected data from all patients aged 18-99 years diagnosed with primary, invasive, colorectal adenocarcinoma from Jan 1, 2010, to Dec 31, 2012, in Denmark, England, Norway, and Sweden, from national colorectal cancer registries. Read More

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December 2018

Outbreak of Acute Gastroenteritis Caused by Norovirus Genogroup II Attributed to Contaminated Cold Dishes on a Cruise Ship in Chongqing, China, 2017.

Int J Environ Res Public Health 2018 Dec 11;15(12). Epub 2018 Dec 11.

Chongqing Municipal Center for Disease Control and Prevention, Chongqing, No. 8, Changjiang 2nd Road, Yuzhong District, Chongqing 400042, China.

In April 2017, several travelers with acute gastroenteritis on a cruise ship were reported. We conducted an investigation to identify the pathogen, mode of transmission, and risk factors. We searched and classified case-patient according to structured case definition, and collect date of the onset, clinical manifestations, and demographic information of cases. Read More

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December 2018

Mid-arm muscle circumference: A significant factor of all-cause and cancer mortalities in individuals with elevated platelet-to-lymphocyte ratio.

PLoS One 2018 13;13(12):e0208750. Epub 2018 Dec 13.

Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Platelet-to-lymphocyte ratio (PLR) is an inflammatory maker, and high PLR is associated with mortality in several diseases. The predictors of mortality in individuals with high PLR is still lacking. Our aims were to assess if mid-arm muscle circumference (MAMC) can predict all-cause mortality, cancer mortality, and cardiovascular mortality in individuals with high PLR. Read More

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December 2018

Risk of postoperative morbidity in patients having bowel resection for colonic Crohn's disease.

Tech Coloproctol 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, Ålborg University Hospital, Ålborg, Denmark.

Background: The aim of the present multicenter study was to analyze the incidence and risk factors associated with postoperative morbidity in patients who had colorectal resection for colonic Crohn's disease.

Methods: Consecutive patients undergoing colorectal resection for colonic Crohn's disease at seven surgical units in 1992-2017 were included. Exclusion criteria were: proctectomy for perianal disease, surgery for cancer, previous colectomies, surgery before 1998. Read More

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December 2018

Isolated thoracic perfusion in lung metastases from breast cancer: a retrospective observational study.

Updates Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.

The median overall survival of metastatic breast cancer (MBC) patients is still approximately 2 years. This is even lower in triple-negative breast cancer (TNBC) patients with concomitant lung metastases. These patients are often not suitable for surgery and not responsive to systemic chemotherapy. Read More

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December 2018

[The evaluation of stored feces in elderly patients by ultrasonography: Three case studies].

Nihon Ronen Igakkai Zasshi 2018 ;55(4):657-662

Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo.

Providing defecation care can be challenging because bowel movements cannot be directly observed in home-care settings, and the objective evaluation of constipation symptoms is difficult, particularly for elderly patients with cognitive impairment. We evaluated the use of rectal ultrasonography (US) to assess the properties and volume of feces in three cases with different fecal properties. Case 1: In a 94-year-old man with normal feces (Bristol stool score: BS type 4), rectal US revealed a crescent-shaped high-echo area without acoustic shadow that was present until the next defecation. Read More

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January 2018

Evaluation of the Amplidiag CarbaR + MCR kit for the accurate detection of carbapenemase-producing and colistin-resistant bacteria.

J Clin Microbiol 2018 Dec 12. Epub 2018 Dec 12.

EA7361 "Structure, dynamic, function and expression of broad spectrum β-lactamases", Université Paris-Sud, Université Paris-Saclay, LabEx Lermit, Faculty of Medicine, Le Kremlin-Bicêtre, France

As carbapenemase-producing Gram-negative bacilli (CP-GNB) co-producing MCR-1 are now emerging, thus compromising the use of last resort antibiotics (carbapenems and colistin), there is an urgent need for accurate and fast diagnostic tests (1-4). We have previously shown that the Amplidiag® CarbaR+VRE assay displayed a high sensitivity and specificity on colonies of CP-GNB, but failed to detect GES carbapenemase-producing organisms (GES-CPO), which represent 11% of the carbapenemase-producing (CP-) in France (5). Moreover, this assay was not validated on clinical samples such as rectal swabs. Read More

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December 2018

[Efficacy and safety of selective brain hypothermia therapy on neonatal hypoxic-ischemic encephalopathy].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1046-1050

Department of Pediatrics, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui, China (Chen X, Peng WS, Zhang Z, Zhao Q, Zhou Y, Chen L); Department of Pediatric, Anhui Provincial Hospital, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, Anhui, China (Pan JH). Corresponding author: Pan Jiahua, Email:

Objective: To evaluate the efficacy and safety of selective brain hypothermia (SBH) in the treatment of neonates with moderate or severe neonatal hypoxic-ischemic encephalopathy (HIE), and the effect of SBH treatment on serum levels of neuron-specific enolase (NSE) and central nervous specific protein S100.

Methods: A prospective randomized controlled trial was conducted. From January 2015 to June 2017, 42 children with moderate to severe HIE in the neonatal intensive care unit (NICU) of the First Affiliated Hospital of Bengbu Medical College were enrolled, and they were randomly divided into SBH treatment group and routine treatment group after obtaining the consent of the guardian of the children. Read More

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November 2018

Remodeling of Rectal Innervation After Pullthrough Surgery for Hirschsprung Disease: Relevance to Criteria for the Determination of Retained Transition Zone.

Pediatr Dev Pathol 2018 Dec 12:1093526618817658. Epub 2018 Dec 12.

7 Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.

Background: After pullthrough surgery for Hirschsprung disease (HSCR), Glut1-positive submucosal nerve hypertrophy is used to diagnose retained transition zone in the neorectum. We hypothesized that pelvic nerves, severed during pullthrough surgery, sprout into the neorectum to mimic transition zone.

Methods: The density (nerves/100x field) and maximum diameter of Glut1-positive submucosal nerves were measured in biopsies and redo resections from 20 patients with post-pullthrough obstructive symptoms. Read More

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December 2018

Molecular Imaging of Cancer Stem Cells for Assessment of Rectal Cancer.

Curr Health Sci J 2015 Oct-Dec;41(4):390-394. Epub 2015 Dec 22.

Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, Romania.

Rectal cancer is one of the most common diagnosed malignancies in the world. We present the case of a 54 years old patient, diagnosed with adenocarcinoma of the rectum and unsuccessful treatment. The possible involvement of cancer stem cells in tumor relapse and treatment failure represents the motivation behind an extensive imaging evaluation. Read More

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December 2015

Current Role of Endoscopic Ultrasonography in Rectal Cancer Evaluation During Multidisciplinary Therapy.

Curr Health Sci J 2015 Jul-Sep;41(3):259-263. Epub 2015 Mar 15.

5Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, Romania; Department of Endoscopy, Copenhagen University Hospital Herlev, Denmark.

We report the case of a patient presenting in the Gastroenterology Department with intermittent rectal bleeding during the past year. A diagnosis of a low rectal adenocarcinoma was based on colonoscopy examination with biopsies, and staging procedures included transrectal endoscopic ultrasonography and magnetic resonance imaging of the abdomen and pelvis (cT2N0M0). Consequently the patient was referred for pre-operative chemoradiotherapy, achieving a complete clinical response as documented by repeated EUS and MRI examinations. Read More

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Evaluation of endoscopic mucosal resection and endoscopic submucosal dissection in submucosal lesions of the colon and rectum.

Wideochir Inne Tech Maloinwazyjne 2018 Dec 8;13(4):448-453. Epub 2018 Oct 8.

Department of General Surgery, Istanbul Training and Research Hospital, Istanbul, Turkey.

Introduction: Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are commonly used for the minimally invasive treatment of submucosal lesions of the gastrointestinal tract.

Aim: To evaluate the safety, efficacy, outcome and recurrence rate of EMR and ESD for mucosal and submucosal lesions in the colon and rectum.

Material And Methods: Records of 26 patients who underwent ESD and EMR for mucosal and submucosal lesions in the colon and rectum between January 2013 and March 2018 in our endoscopy unit were retrospectively reviewed. Read More

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December 2018

Early closure of the protective ileostomy after rectal resection should become part of the Enhanced Recovery After Surgery (ERAS) protocol: a randomized, prospective, two-center clinical trial.

Wideochir Inne Tech Maloinwazyjne 2018 Dec 13;13(4):435-441. Epub 2018 Nov 13.

2 Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland.

Introduction: Protective loop ileostomy (PLI) is used to reduce the anastomotic leak rate after resection of the rectum. It is an effective, yet burdensome procedure contradicting the aims of enhanced recovery after surgery (ERAS) by slowing down recovery. Early closure (EC) of the PLI has the potential to change the situation, and it should become part of ERAS. Read More

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December 2018

Validation of non-invasive brain temperature estimation models during swine therapeutic hypothermia.

Physiol Meas 2018 Nov 14. Epub 2018 Nov 14.

Department of Biomedical Engineering, Seoul National University, Seoul, KOREA, REPUBLIC OF.

Objectives: This paper introduces a mathematical model that can estimate deep brain temperature during therapeutic hypothermia based on a double sensor method. Although the cerebral temperature is more important than the non-cerebral core temperature during therapeutic hypothermia, pulmonary artery, rectal, and esophageal measurements (i.e. Read More

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November 2018

CO embolism can complicate transanal total mesorectal excision.

Tech Coloproctol 2018 Dec 6. Epub 2018 Dec 6.

Division of Colon and Rectal Surgery, University of Massachusetts Medical School, 67 Belmont Street, Suite 201, Worcester, MA, 01604, USA.

Background: Carbon dioxide (CO) embolism is a rare but potentially devastating complication of minimally invasive abdominal and retroperitoneal surgery. Characterized by a decrease in end-tidal CO (ETCO) and oxygen saturation (SpO), CO emboli can cause rapid intraoperative hypotension and cardiovascular collapse. Transanal total mesorectal excision (taTME) is a novel surgical approach for rectal resection, which requires high flow CO insufflation in a low volume operative field. Read More

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December 2018

Management of retrorectal hematoma after stapled transanal rectal resection for prolapsed hemorrhoids associated with occult rectal prolapse and obstructed defecation syndrome.

Tech Coloproctol 2018 Dec 6. Epub 2018 Dec 6.

AUSL della Romagna, Department of General Surgery, Ospedale per gli Infermi, Faenza, Italy.

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December 2018

Management of some extra-peritoneal rectal injuries without fecal diversion may be feasible, but high-quality evidence is still needed.

Authors:
R W Schroll

Tech Coloproctol 2018 Dec 6. Epub 2018 Dec 6.

Department of Surgery, Tulane University School of Medicine, 1430 Tulane Ave, #8622, New Orleans, LA, 70112, USA.

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December 2018

Different clinical features according to the anastomotic leakage subtypes after rectal cancer surgeries: contained vs. free leakages.

PLoS One 2018 12;13(12):e0208572. Epub 2018 Dec 12.

Division of Colon and Rectal Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.

Background: Anastomotic leakage can be classified by free and contained leakage according to clinical manifestations. The risk factors and their comparison between these leakage subtypes are uncertain. This study aims to evaluate anastomotic leakage patterns and to compare clinical features between free and contained leakages after low anterior resection for rectal cancer. Read More

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December 2018
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En-Bloc Excision of the High-ligated Inferior Mesenteric Vein Pedicle With the Specimen in Patients Undergoing Minimally Invasive and Open Sphincter Saving Rectal Resections for Cancer.

Surg Laparosc Endosc Percutan Tech 2018 Dec 11. Epub 2018 Dec 11.

Departments of General Surgery.

Although high-ligated pedicle of the inferior mesenteric artery is usually kept in the resected specimens, the value of preserving high-ligated pedicle of the inferior mesenteric vein within the resected specimens of the sphincter saving rectal resections for cancer is not well defined. In the current study, patients undergoing open, laparoscopic, and robotic sphincter saving rectal resection for cancer were prospectively included. Lymph node invasion and presence of lymph nodes along the IMV pedicles were analyzed. Read More

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December 2018
1 Read

Sonic Hedgehog Protein is Frequently Up-Regulated in Pancreatic Cancer Compared to Colorectal Cancer.

Pathol Oncol Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, 190011, India.

Sonic hedgehog (SHH) is a secreted protein which functions in autocrine or paracrine fashion on target cells to activate hedgehog (HH) signalling cascade responsible for growth and proliferation. This study is an attempt to understand the expression dynamics of SHH protein in colon, rectal and pancreatic cancers. Protein expression of SHH was studied by Western Blotting in the histologically confirmed colon, rectum and pancreatic cancer tissue samples along with their adjacent normal tissues. Read More

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December 2018

Multiplex amplification refractory mutation system PCR (ARMS-PCR) provides convenient method for differentiation of canine parvovirus vaccine and field strains.

Virusdisease 2018 Dec 26;29(4):565-568. Epub 2018 Sep 26.

1Centre of Animal Disease Diagnosis and Research, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, UP 243122 India.

Vaccination with canine parvovirus-2 (CPV-2) modified live attenuated vaccine remains an effective control strategy for preventing parvovirus induced enteritis in dogs. Virus shedding is a common phenomenon few days after vaccination, possessing a diagnostic dilemma for accurate differentiation of CPV-2 vaccine and wild type field strains. Though several molecular approaches are available for differentiation, the present study focuses on a simple, rapid, cost-effective differentiating infected from vaccinated animals strategy employing ARMS-PCR for differentiation of CPV-2 vaccine and wild type field strains. Read More

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December 2018
1 Read

Bladder Invasion in Patients with Advanced Colorectal Carcinoma.

Indian J Surg Oncol 2018 Dec 23;9(4):547-551. Epub 2018 Jul 23.

5Department of Biotechnology and Microbiology, Karnatak University, Dharwad, 580003 Karnataka India.

Involvement of the bladder by colorectal cancer is sufficiently rare to be encountered by an individual surgeon on an infrequent basis. Extirpative procedures for advanced colorectal cancers can involve partial/total bladder resections. In patients without evidence of distant metastatic disease, a reasonable therapeutic effect can be expected when negative surgical margins are obtained. Read More

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December 2018

Chemo-Radiation After Upfront Rectal Resections-a Clinical Dilemma.

Indian J Surg Oncol 2018 Dec 18;9(4):495-500. Epub 2018 Aug 18.

Department of Gastrointestinal Surgery and Colorectal Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra 400012 India.

To compare the impact of adjuvant chemo-radiotherapy (ACRT) versus adjuvant chemotherapy (ACT) alone on recurrence and survival in patients with stage II and III rectal adenocarcinoma undergoing upfront curative resection. Prospective observational review of colorectal database at Tata Memorial Hospital from July 2010 to March 2015 identified 84 patients who underwent upfront curative resection for stage II or III rectal cancer. None of the patient received preoperative chemo-radiation. Read More

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December 2018

Clinical Utility of Staging Laparoscopy for Advanced Obstructing Rectal Adenocarcinoma: Emerging Tool.

Indian J Surg Oncol 2018 Dec 2;9(4):488-494. Epub 2018 Aug 2.

1Department of Gastrointestinal Surgery and Colorectal Surgical Oncology, Tata Memorial Hospital, Dr Ernest Borges Marg, Parel, Mumbai, Maharashtra 400012 India.

The multimodal treatment for advanced rectal adenocarcinoma mandates accurate preoperative staging with contrast-enhanced computed tomography (CECT) of the thorax, abdomen, and pelvis, and magnetic resonance imaging (MRI) of the pelvis. Unlike gastric cancer, the role of staging laparoscopy (SL) in advanced colorectal cancer has not been evaluated. This study aims to evaluate the clinical value of SL in treatment decision-making for advanced rectal cancer (RC) with near or complete obstructing tumors. Read More

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December 2018

Transanal Total Mesorectal Excision for Treatment of Carcinoma in the Middle or Lower Third Rectum: the Technical Feasibility of the Procedure, Pathological Results, and Clinical Outcome.

Indian J Surg Oncol 2018 Dec 4;9(4):442-451. Epub 2018 Aug 4.

3Pathology Department, Faculty of Medicine, Benha University, Benha, Egypt.

We are trying to illustrate operative, short-term, and pathological outcomes of transanal total mesorectal excision (TaTME) as a surgical procedure for patients who are suffering cancer in the lower or middle rectum. This study included 25 consecutive patients who underwent TaTME for the mid and low cancer rectum. The primary outcome measures included frequency of postoperative (PO) bleeding, leakage, ileus, days to regain bowel function, days for Foley's removal, and erectile function. Read More

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December 2018

Clinical benefit of high resolution anorectal manometry for the evaluation of anal function after intersphincteric resection.

Colorectal Dis 2018 Dec 8. Epub 2018 Dec 8.

Department of Colorectal Surgery, National Cancer Center Hospital East, Chiba, Japan, 6-5-1, Kashiwanoha, Kashiwa-City, Chiba, 277-8577, Japan.

Aim: Intersphincteric resection (ISR) is an advanced anus-preserving operation for treating low rectal cancer while avoiding colostomy. High-resolution anorectal manometry (HR-ARM) allows objective and accurate evaluation of anal function. However, correlations between anal function after ISR and HR-ARM parameters are unknown. Read More

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December 2018

Incidence, severity, longitudinal trends and predictors of acute and chronic oxaliplatin-induced peripheral neuropathy in Taiwanese patients with colorectal cancer.

Eur J Cancer Care (Engl) 2018 Dec 10:e12976. Epub 2018 Dec 10.

Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Lin-Ko, Taiwan.

The purpose of this study was to evaluate the longitudinal incidence, severity, pattern of changes or predictors of oxaliplatin-induced peripheral neuropathy (OXAIPN) in Taiwanese patients with colorectal cancer. A longitudinal repeated measures study design was employed, and 77 participants were recruited from the colorectal and oncology departments of two teaching medical centres in Taiwan. Physical examinations were performed, and self-reports regarding adverse impacts of OXAIPN and quality of life were obtained at five time points throughout 12 cycles of chemotherapy (C/T). Read More

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December 2018
1 Read

Genome sequence characterization of canine parvoviruses prevalent in the Sichuan province of China.

Transbound Emerg Dis 2018 Dec 11. Epub 2018 Dec 11.

China Animal Health and Epidemiology Center, Qingdao, Shandong Province, China.

Canine parvovirus 2 (CPV-2) infection is responsible for large numbers of animal deaths worldwide and is one of the most dangerous infectious diseases in young puppies. Twenty-four rectal swabs were collected from dogs with clinical signs of vomiting and hemorrhagic diarrhea and were initially verified to be infected with CPV-2 using colloidal gold test strips. From the 24 CPV-positive samples, complete genome of 5050-5054 nucleotides was sequenced with a next-generation sequencing platform. Read More

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December 2018

Heat acclimation does not affect maximal aerobic power in thermoneutral normoxic or hypoxic conditions.

Exp Physiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Automation, Biocybernetics and Robotics, Jozef Stefan Institute, Ljubljana, Slovenia.

What is the central question of this study? Controlled-hyperthermia heat acclimation protocols induce an array of thermoregulatory and cardiovascular adaptations that facilitate exercise in hot conditions. We investigated whether this ergogenic potential can be transferred to thermoneutral normoxic or hypoxic exercising conditions. What is the main finding and its importance? We show that heat acclimation did not affect maximal cardiac output or maximal aerobic power in thermoneutral normoxic/hypoxic conditions. Read More

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December 2018
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Neurologic recovery after deep hypothermic circulatory arrest in rats: A description of a long-term survival model without blood priming.

Artif Organs 2018 Dec 8. Epub 2018 Dec 8.

Department of Cardiopulmonary Bypass, State key laboratory of Cardiovascular Medicine, Fuwai Hospital, National center for Cardiovascular disease, Chinese Academy of Medical science and Peking Union Medical College, Beijing, China.

Brain injury associated with deep hypothermic circulatory arrest (DHCA) has been recognized in patients with congenital heart diseases and those undergoing aortic arch surgeries. However, the preclinical investigation of long-term cerebral injury and recovery mechanisms related to DHCA has been restricted to a satisfactory recovery animal model with a determined recovery time. This study aimed to evaluate the feasibility of a long-term surviving DHCA model without blood priming in rats, in order to investigate the pathophysiology of long-term complications in further studies. Read More

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December 2018

Global trends in colorectal cancer mortality: projections to the year 2035.

Int J Cancer 2018 Dec 10. Epub 2018 Dec 10.

Section of Cancer Surveillance, International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon, France.

Colorectal cancer (CRC) is the third most common cancer worldwide and the fourth most common cause of cancer death. Predictions of the future burden of the disease inform health planners and raise awareness of the need for cancer control action. Data from the World Health Organization (WHO) mortality database for 1989-2016 were used to project colon and rectal cancer mortality rates and number of deaths in 42 countries up to the year 2035, using age-period-cohort (APC) modelling. Read More

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December 2018
1 Read

Too Many Biopsies Performed to Rule Out Hirschsprung's Disease: But It is Worth Doing Them.

Eur J Pediatr Surg 2018 Dec 10. Epub 2018 Dec 10.

Department of Paediatric Surgery, Noah's Ark Children's Hospital for Wales, Cardiff, United Kingdom.

Introduction:  The U.K. National Institute for Health and Clinical Excellence (NICE) specify the following indications for performing rectal biopsy to rule out Hirschsprung's disease (HSD): (1) passage of meconium > 48 hours; (2) constipation since first few weeks of life; (3) chronic abdominal distension with vomiting; (4) family history of HSD; and (5) faltering growth in addition to any other indication. Read More

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December 2018

Safe adoption of robotic colorectal surgery using structured training: early Irish experience.

J Robot Surg 2018 Dec 10. Epub 2018 Dec 10.

Beacon Hospital, Beacon Court, Sandyford, Dublin 18, Republic of Ireland.

Robotic surgery enhances the precision of minimally invasive surgery through improved three-dimensional views and articulated instruments. There has been increasing interest in adopting this technology to colorectal surgery and this has recently been introduced to the Irish health system. This paper gives an account of our early institutional experience with adoption of robotic colorectal surgery using structured training. Read More

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December 2018
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A propensity score matched comparison of intracorporeal and extracorporeal techniques for robotic-assisted sigmoidectomy in an enhanced recovery pathway.

J Robot Surg 2018 Dec 10. Epub 2018 Dec 10.

Division of Colon and Rectal Surgery, St. Joseph Mercy Hospital, Ann Arbor, 5325 Elliott Dr., Suite #104, Ann Arbor, MI, 48106, USA.

Intracorporeal options for sigmoid resection have been recently developed but not extensively evaluated. This study was designed to assess outcomes comparing intracorporeal and extracorporeal techniques for robotic-assisted sigmoid resection in an established enhanced recovery pathway. This is a retrospective comparison of intracorporeal and extracorporeal techniques for robotic-assisted sigmoid resection for benign and malignant disease. Read More

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December 2018
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Impact of Long-Course Neoadjuvant Radiation on Postoperative Low Anterior Resection Syndrome and Quality of Life in Rectal Cancer: Post Hoc Analysis of a Randomized Controlled Trial.

Ann Surg Oncol 2018 Dec 7. Epub 2018 Dec 7.

Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

Background: Neoadjuvant radiation is recommended for locally advanced rectal cancer, with proven benefit in local control but not in disease-free survival. However, the impact of long-course radiation on postoperative bowel function and quality of life (QOL) remains controversial. This study aimed to investigate the impact of long-course neoadjuvant radiation on bowel function and QOL, and to identify risk factors for severe bowel dysfunction. Read More

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December 2018

[Evaluation of three screening methods for detection of carbapenemase-producing Enterobacteriaceae in rectal swabs].

Rev Chilena Infectol 2018 ;35(3):253-261

PROASECAL SAS, Bogotá, Colombia.

Background: Carbapenemase-producing Enterobacteriaceae (CPE) have taken great importance on public health at global scale, which makes it necessary to implement rapid test for its prompt detection.

Aim: To evaluate three screening methods to detect CPE in rectal swabs.

Material And Methods: Transverse study, prospective. Read More

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January 2018

Travel to Asia is a strong predictor for carriage of cephalosporin resistant and but does not explain everything; prevalence study at a Norwegian hospital 2014-2016.

Antimicrob Resist Infect Control 2018 29;7:146. Epub 2018 Nov 29.

1Department of Antibiotic Resistance and Infection Prevention, Norwegian Institute of Public Health, PO Box 222 Skøyen, 0213 Oslo, NO Norway.

Background: We aimed to estimate the prevalence of faecal carriage of extended-spectrum cephalosporin (ESC) resistant and (ESCr-EK) and vancomycin resistant enterococci (VRE) in patients upon hospital admission and identify factors associated with carriage to better target interventions and to guide empirical antibiotic treatment.

Methods: Between October 2014 and December 2016, we recruited patients admitted to a Norwegian university hospital. A rectal swab and questionnaire covering possible risk factors for colonisation were collected upon admission. Read More

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November 2018

The acceptability of screening for Carbapenemase Producing (CPE): cross-sectional survey of nursing staff and the general publics' perceptions.

Antimicrob Resist Infect Control 2018 23;7:144. Epub 2018 Nov 23.

1School of Health & Life Sciences, Glasgow Caledonian University, Cowcaddens Road, Glasgow, Scotland G4 0BA UK.

Background: Carbapenemase Producing (CPE) has spread rapidly and presents a growing challenge in antimicrobial resistance (AMR) management internationally. Screening for CPE may involve a rectal swab, there are limited treatment options for affected patients, and colonised patients are cared for in isolation to protect others. These measures are sound infection prevention precautions; however, the acceptability of CPE screening and its consequences are currently unknown. Read More

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November 2018

Image-guided brachytherapy in cervical cancer: Experience in the Complejo Hospitalario de Navarra.

Rep Pract Oncol Radiother 2018 Nov-Dec;23(6):510-516. Epub 2018 Oct 19.

Department of Radiation Oncology, Hospital de Navarra, Pamplona, Spain.

Purpose: To evaluate dosimetric and clinical findings of MRI-guided HDR brachytherapy (HDR-B) for cervical carcinoma.

Material And Methods: All patients had a CT, MRI and pelvic-paraaortic lymphadenectomy. Treatment: pelvic (+/-)para-aortic3D/IMRT radiotherapy (45 Gy), weekly cisplatin and HDR-B and pelvic node/parametrial boost 60 Gy until interstitial brachytherapy was done. Read More

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October 2018

Molecular detection of and genes among vancomycin-resistant enterococci in ICU-hospitalized patients in Ahvaz in southwest of Iran.

Infect Drug Resist 2018 15;11:2269-2275. Epub 2018 Nov 15.

School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objective: Nosocomial infections due to vancomycin-resistant enterococci (VRE) are known as a source of spreading these bacteria. The aim of this prospective study was molecular detection of and genes among VRE isolated from patients admitted to intensive care units (ICUs) in Ahvaz in southwest of Iran.

Materials And Methods: Overall, 243 non-duplicate rectal swab specimens were collected from ICU-hospitalized patients in teaching hospitals affiliated to Ahvaz Jundishapur University of Medical Sciences, Iran. Read More

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November 2018

Occurrence of carrying Shiga toxin-producing genes in buffaloes on smallholdings in Bangladesh.

Vet World 2018 Nov 19;11(10):1454-1458. Epub 2018 Oct 19.

Department of Genetics and Animal Breeding, Faculty of Veterinary Medicine, Chittagong Veterinary and Animal Sciences University, Khulshi, Chittagong 4225, Bangladesh.

Background And Aim: Shiga toxin-producing (STEC) has emerged as significant foodborne pathogens. Ruminants are the primary reservoir of the zoonotic STEC. In Bangladesh, previous studies reported the presence of STEC in cattle, goat, and sheep; however, there is little information about STEC carriage by buffaloes. Read More

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November 2018

Role of a fluid-phase PRR in fighting an intracellular pathogen: PTX3 in Shigella infection.

PLoS Pathog 2018 Dec 7;14(12):e1007469. Epub 2018 Dec 7.

Department of Biology and Biotechnology "Charles Darwin", Sapienza-Università di Roma, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Roma, Italy.

Shigella spp. are pathogenic bacteria that cause bacillary dysentery in humans by invading the colonic and rectal mucosa where they induce dramatic inflammation. Here, we have analyzed the role of the soluble PRR Pentraxin 3 (PTX3), a key component of the humoral arm of innate immunity. Read More

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December 2018

Streptococcus agalactiae is not always an obligate intramammary pathogen: Molecular epidemiology of GBS from milk, feces and environment in Colombian dairy herds.

PLoS One 2018 10;13(12):e0208990. Epub 2018 Dec 10.

Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

For many years Streptococcus agalactiae has been considered an obligate intramammary and strictly contagious pathogen in dairy cattle. However, recent reports of S. agalactiae isolation from extramammary sources have contradicted that premise. Read More

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December 2018

Dexmedetomidine combined with etomidate or emulsified isoflurane for induction reduced cardiopulmonary response in dogs.

PLoS One 2018 7;13(12):e0208625. Epub 2018 Dec 7.

College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.

To investigate the effects of etomidate, emulsified isoflurane, and their combination with dexmedetomidine on physiological parameters, electrocardiogram (ECG) results, and the quality of induction and recovery during isoflurane maintenance anaesthesia. 5 mixed-breed dogs received each of four treatments: etomidate (E group); emulsified isoflurane (EI group); both dexmedetomidine and etomidate (DE group); or both dexmedetomidine and emulsified isoflurane (DEI group). All drugs were IV injection administered for induction, followed by 1. Read More

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December 2018