66,596 results match your criteria Rectal Cancer


Comparison of overall survival and quality of life between patients undergoing anal reconstruction and patients undergoing traditional lower abdominal stoma after radical resection.

Clin Transl Oncol 2019 Apr 20. Epub 2019 Apr 20.

The Department of General Surgery, Second Hospital of Lanzhou University, No. 82, Cuiying Gate, Chengguan District, Lanzhou, 730030, Gansu, China.

Background: Miles procedure is often necessary for patients with low rectal carcinoma. However, this operation often affects the quality of life of patients, to evaluate the advantages of improved operation (anal reconstruction), the quality of life and survival between patients undergoing anal reconstruction and patients undergoing traditional lower abdominal stoma after radical resection were analyzed.

Methods: The clinical data of 43 patients with low situated rectal carcinoma were retrospectively analyzed. Read More

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http://dx.doi.org/10.1007/s12094-019-02106-xDOI Listing

Increased incidence of colon cancer among individuals younger than 50 years: A 17 years analysis from the cancer registry of the municipality of Milan, Italy.

Cancer Epidemiol 2019 Apr 18;60:134-140. Epub 2019 Apr 18.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda and Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy.

Background: Colorectal cancer (CRC) overall incidence has been decreasing in the last decade. However, there is evidence of an increasing frequency of early-onset CRC in young individuals in several countries. The aim of this study is to evaluate the trends of CRC occurrence over 17 years in the municipality of Milan, Italy, focusing on early-onset CRC. Read More

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http://dx.doi.org/10.1016/j.canep.2019.03.015DOI Listing

Long-term results of a multicenter phase II study of preoperative chemoradiotherapy with S-1 plus oxaliplatin for locally advanced rectal cancer (JACCRO CC-04: SHOGUN Trial).

Radiother Oncol 2019 May 26;134:199-203. Epub 2019 Feb 26.

Japan Clinical Cancer Research Organization, Tokyo, Japan.

Purpose: The study was designed to evaluate the safety and efficacy of adding oxaliplatin to py (CRT) with S-1 in patients with locally advanced rectal carcinoma (LARC). We report here the final results of the study.

Patients And Methods: Patients with histopathologically confirmed LARC (cT3-T4, any N) were eligible. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.02.006DOI Listing
May 2019
2 Reads

The INTERACT Trial: Long-term results of a randomised trial on preoperative capecitabine-based radiochemotherapy intensified by concomitant boost or oxaliplatin, for cT2 (distal)-cT3 rectal cancer.

Radiother Oncol 2019 May 7;134:110-118. Epub 2019 Feb 7.

Radiation Oncology Department, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.

Background And Purpose: Capecitabine-based radiochemotherapy (cbRCT) is standard for preoperative long-course radiochemotherapy of locally advanced rectal cancer. This prospective, parallel-group, randomised controlled trial investigated two intensification regimens. cT4 lesions were excluded. Read More

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http://dx.doi.org/10.1016/j.radonc.2018.11.023DOI Listing
May 2019
1 Read

Which clinical and radiological characteristics can predict clinically significant prostate cancer in PI-RADS 3 lesions? A retrospective study in a high-volume academic center.

Eur J Radiol 2019 May 25;114:92-98. Epub 2019 Feb 25.

Department of Radiology, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium. Electronic address:

Objective: To investigate which clinical and radiological characteristics can predict clinically significant prostate cancer (csPCa) in PI-RADS 3 lesions. To investigate which clinical and radiological characteristics influence the clinician to biopsy a PI-RADS 3 lesion.

Materials And Methods: mpMRI PI-RADS 3 lesions scored by 1 out of 3 highly specialized radiologists in a single high-volume center during the period March 2015 to August 2017 were investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X193008
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http://dx.doi.org/10.1016/j.ejrad.2019.02.031DOI Listing
May 2019
1 Read

EUS versus Magnetic Resonance Imaging in Staging Rectal Adenocarcinoma: A Diagnostic Test Accuracy Meta-Analysis.

Gastrointest Endosc 2019 Apr 17. Epub 2019 Apr 17.

Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada; Gastrointestinal Health Technology Assessment Group, The Farncombe Family Digestive Health Research Institute, Hamilton, Ontario, Canada.

Backgrounds And Aims: EUS and magnetic resonance imaging (MRI) are both used for locoregional staging of rectal cancer, which determines treatment options. There is a lack of consensus on the best modality for locoregional staging, with studies supporting both EUS and MRI. In this study, we performed the first diagnostic test accuracy meta-analysis to compare the diagnostic accuracy, sensitivity, and specificity of EUS and MRI in the staging of rectal cancer. Read More

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http://dx.doi.org/10.1016/j.gie.2019.04.217DOI Listing

Locally advanced rectal cancer: qualitative and quantitative evaluation of diffusion-weighted magnetic resonance imaging in restaging after neoadjuvant chemo-radiotherapy.

Abdom Radiol (NY) 2019 Apr 19. Epub 2019 Apr 19.

Division of Radiology 2, Department of Surgical and Biomedical Sciences, Santa Maria della Misericordia Hospital, Perugia, Italy.

Purpose: To determine the added value of qualitative and quantitative evaluation of diffusion-weighted magnetic resonance imaging (DWI) in locally advanced rectal cancer (LARC) restaging after neoadjuvant chemo-radiotherapy (CRT).

Materials And Methods: A retrospective study was performed of 21 patients with LARC treated with CRT. All patients were evaluated with 1. Read More

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http://link.springer.com/10.1007/s00261-019-02012-4
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http://dx.doi.org/10.1007/s00261-019-02012-4DOI Listing
April 2019
1 Read

Who Can Avoid Systematic Biopsy Without Missing Clinically Significant Prostate Cancer in Men Who Undergo Magnetic Resonance Imaging-Targeted Biopsy?

Clin Genitourin Cancer 2019 Mar 27. Epub 2019 Mar 27.

Department of Urology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan. Electronic address:

Background: The objective of the study was to identify a subset of men who can avoid systematic multisite biopsy (SyB) among those undergoing magnetic resonance imaging (MRI)-targeted transperineal 4-core biopsy (TgB) without missing clinically significant cancer (SC).

Patients And Methods: From April 2013 to December 2017, 304 men with elevated prostate-specific antigen levels (< 20 ng/mL) or abnormal digital rectal examination and positive MRI findings underwent transrecta ultrasound and MRI-targeted transperineal 4-core with 14-core systematic biopsy. MRI findings were prospectively collected and evaluated using Prostate Imaging-Reporting and Data System version 2 (PI-RADS), and scores ≥3 were considered positive. Read More

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http://dx.doi.org/10.1016/j.clgc.2019.03.011DOI Listing

Time trends of short-term mortality for octogenarians undergoing a colorectal resection in North Europe.

Eur J Surg Oncol 2019 Apr 9. Epub 2019 Apr 9.

Department of Surgical Oncology, Leiden University Medical Center, the Netherlands. Electronic address:

Background: Decreased cancer specific survival in older colorectal patients is mainly due to mortality in the first year, emphasizing the importance of the first postoperative year. This study aims to gain an overview and time trends of short-term mortality in octogenarians (≥80 years) with colorectal cancer across four North European countries.

Methods: Patients of 80 years or older, operated for colorectal cancer (stage I-III) between 2005 and 2014, were included. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.03.041DOI Listing

[Prophylactic hysterectomy in Lynch syndrome: feasibility and outcomes].

Gynecol Obstet Fertil Senol 2019 Apr 16. Epub 2019 Apr 16.

Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Chirurgie Cancérologique Gynécologique et du Sein, Paris, France; Université Paris Descartes, INSERM UMR-S 747, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France. Electronic address:

Objectives: Lynch syndrome (LS) is a hereditary predisposition to cancers, first of all, colo-rectal and endometrial cancers in women. Although recommended, gynecologic screening has never proven its benefit. Prophylactic surgery can be consider once the parental project is completed. Read More

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http://dx.doi.org/10.1016/j.gofs.2019.04.010DOI Listing

Stereotactic Body Radiotherapy Boost for Intermediate Risk Prostate Cancer: A Phase 1 Dose Escalation Study.

Int J Radiat Oncol Biol Phys 2019 Apr 16. Epub 2019 Apr 16.

Sunnybrook Odette Centre; Department of Radiation Oncology, University of Toronto. Electronic address:

Purpose: HDR brachytherapy boost plus external beam radiotherapy is an established option for intermediate risk prostate cancer (PCa). SBRT boost can potentially mimic HDR boost, and could be a viable alternative. Here we report the long-term outcomes of a phase I dose-escalation trial of single-fraction SBRT boost. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.04.006DOI Listing

Phase 2 Multicenter Study of Gantry-Based Stereotactic Radiotherapy Boost for Intermediate and High Risk Prostate Cancer (PROMETHEUS).

Front Oncol 2019 2;9:217. Epub 2019 Apr 2.

Department of Radiation Oncology, Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia.

To report feasibility, early toxicity, and PSA kinetics following gantry-based, stereotactic radiotherapy (SBRT) boost within a prospective, phase 2, multicenter study (PROMETHEUS: ACTRN12615000223538). Patients were treated with gantry-based SBRT, 19-20 Gy in two fractions delivered 1 week apart, followed by conventionally fractionated IMRT (46 Gy in 23 fractions). The study mandated MRI fusion for RT planning, rectal displacement, and intrafraction image guidance. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2019.00217/
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http://dx.doi.org/10.3389/fonc.2019.00217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454110PMC
April 2019
1 Read

Lymph node yield, survival benefit, and safety of high and low ligation of the inferior mesenteric artery in colorectal cancer surgery: a systematic review and meta-analysis.

Int J Colorectal Dis 2019 Apr 17. Epub 2019 Apr 17.

Department of General Surgery, Gansu Provincial Hospital, Donggang West Road, Lanzhou, 730000, People's Republic of China.

Purpose: The aim of this meta-analysis was to compare high inferior mesenteric artery (IMA) ligation (HL) with low IMA ligation (LL) for the treatment of colorectal cancer and to evaluate the lymph node yield, survival benefit, and safety of these surgeries.

Methods: PubMed, Embase, Cochrane Library, Web of Science, and China Biomedical Literature Database (CBM) were systematically searched for relevant articles that compared HL and LL for sigmoid or rectal cancer. We calculated the odds ratio (OR) with 95% confidence intervals (CIs) for dichotomous outcomes and the weighted mean difference (WMD) for continuous outcomes. Read More

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http://dx.doi.org/10.1007/s00384-019-03291-5DOI Listing
April 2019
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Resting vector volume measured before ileostomy reversal may be a predictor of major fecal incontinence in patients with mid or low rectal cancer: a longitudinal cohort study using a prospective clinical database.

Int J Colorectal Dis 2019 Apr 17. Epub 2019 Apr 17.

Department of Surgery, Seoul National University Bundang Hospital, 82 Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, South Korea.

Purpose: Despite a high incidence of fecal incontinence following sphincter-preservation surgery (SPS), there are no definitive factors measured before ileostomy reversal that predict fecal incontinence. We investigated whether vector volume anorectal manometry before ileostomy reversal predicts major fecal incontinence following SPS in patients with mid or low rectal cancer.

Methods: This longitudinal prospective cohort study comprised 173 patients who underwent vector volume anorectal manometry before ileostomy reversal. Read More

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http://dx.doi.org/10.1007/s00384-019-03293-3DOI Listing
April 2019
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The Increasingly Complicated Approach to Rectal Cancer.

Authors:
David P Ryan

Oncologist 2019 Apr 17. Epub 2019 Apr 17.

Division of Hematology/Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA

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http://dx.doi.org/10.1634/theoncologist.2018-0355DOI Listing

Mucin-Containing Rectal Carcinomas: Overview of Unique Clinical and Imaging Features.

AJR Am J Roentgenol 2019 Apr 17:1-9. Epub 2019 Apr 17.

3 Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI.

The purpose of this study is to review the unique clinical and imaging features of mucin-containing rectal carcinomas. Mucinous rectal carcinoma is an uncommon tumor subtype with a worse prognosis. At MRI, it is marked by T2-hyperintense extracellular mucin. Read More

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https://www.ajronline.org/doi/10.2214/AJR.18.20864
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http://dx.doi.org/10.2214/AJR.18.20864DOI Listing
April 2019
1 Read

Preoperative Diagnosis of Regional Lymph Node Metastasis of Colorectal Cancer With Quantitative Parameters From Dual-Energy CT.

AJR Am J Roentgenol 2019 Apr 17:1-9. Epub 2019 Apr 17.

1 Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yanjiang Rd W, Guangzhou 510120, China.

The purpose of this study was to investigate the performance of quantitative parameters derived from dual-energy CT (DECT) in the preoperative diagnosis of regional metastatic lymph nodes (LNs) in patients with colorectal cancer. Triphasic contrast-enhanced DECT was performed for 178 patients with colon or high rectal cancer. The morphologic criteria, short-axis diameter, and quantitative DECT parameters of the largest regional LN were measured and compared between pathologically metastatic and nonmetastatic LNs. Read More

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http://dx.doi.org/10.2214/AJR.18.20843DOI Listing

CT Staging to Triage Selection of Patients with Poor-Prognosis Rectal Cancer for Neoadjuvant Treatment.

AJR Am J Roentgenol 2019 Apr 17:1-7. Epub 2019 Apr 17.

1 Radiology Department, University of São Paulo School of Medicine, Travessa da Rua Dr, Ovídio Pires de Campos, 75, São Paulo, Brazil.

The purpose of this study was to evaluate CT as a screening tool for determining high risk of local recurrence of rectal tumors in a scenario of limited MRI availability. Data were retrospectively analyzed for 180 consecutively registered patients with rectal adenocarcinoma and no previous treatment who underwent baseline CT and MRI staging within 30 days of each other. Two radiologists independently reviewed CT and MR images. Read More

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http://dx.doi.org/10.2214/AJR.18.20929DOI Listing

Adjuvant chemotherapy for rectal cancer: playing the devil's advocate.

Curr Opin Oncol 2019 Apr 15. Epub 2019 Apr 15.

Gastrointestinal Unit, Department of Medical Oncology, Institut Jules Bordet - Université Libre de Bruxelles (ULB), Brussels, Belgium.

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http://dx.doi.org/10.1097/CCO.0000000000000545DOI Listing
April 2019
1 Read

Clinical and pathological outcomes of induction chemotherapy before neoadjuvant radiotherapy in locally-advanced rectal cancer.

J Surg Oncol 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgery, Division of Colorectal Surgery, Michigan Medicine, Ann Arbor, Michigan.

Background And Objectives: In North America, preoperative combination chemoradiation is the most commonly recommended and utilized approach to locally advanced rectal cancer. There is increasing interest in the use of induction chemotherapy (IC) before radiation and surgery in locally advanced rectal cancer. How widely IC is being used and whether it improves pathologic and oncologic outcomes is unknown. Read More

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http://dx.doi.org/10.1002/jso.25474DOI Listing

Mucinous rectal cancer: concepts and imaging challenges.

Abdom Radiol (NY) 2019 Apr 16. Epub 2019 Apr 16.

Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 29, New York, NY, 10065, USA.

Rectal adenocarcinoma with mucinous components is an uncommon type of rectal cancer with two distinct histologic subtypes: mucinous adenocarcinoma and signet-ring cell carcinoma. Mucin can also be identified as pattern of response after neoadjuvant treatment. On imaging modalities, mucin typically demonstrates high signal intensity on T2-weighted images, low attenuation on computed tomography, and may be negative on 18-fluorodeoxyglucose positron emission tomography. Read More

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http://dx.doi.org/10.1007/s00261-019-02019-xDOI Listing

Postoperative Urinary Retention After Laparoscopic Colorectal Resection with Early Catheter Removal: A Prospective Observational Study.

World J Surg 2019 Apr 16. Epub 2019 Apr 16.

Colorectal Cancer Unit, Department of Surgery, Zealand University Hospital, Roskilde, Sygehusvej 10, 4000, Roskilde, Denmark.

Background: Early catheter removal is essential to enhance postoperative mobilization and recovery, but may carry a risk of urinary retention. This study aimed to evaluate a standardized regimen for early postoperative catheter removal and re-catheterization in patients undergoing elective laparoscopic colorectal cancer surgery within an optimal ERAS setting.

Methods: This was a single-center prospective study of patients undergoing elective minimally invasive colorectal resection and postoperative catheter removal within 24 h, with a re-catheterization threshold of 800 ml bladder volume. Read More

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http://dx.doi.org/10.1007/s00268-019-05010-1DOI Listing

Preservation of left colic artery with lymph node dissection of IMA root during laparoscopic surgery for rectosigmoid cancer. Results of a retrospective analysis.

Clin Ter 2019 Mar-Apr;170(2):e124-e128

Department of Surgery "P. Valdoni", Sapienza University, Rome.

Background: During sigmoid or rectal cancer surgery, dissection of lymph-nodes at the origin of inferior mesenteric artery is mandatory. Nevertheless, ligation of the origin of IMA should compromise blood supply to left colon and affect anastomosis. The aim of this retrospective evaluation is to compare high IMA ligation and low IMA ligation with preservation of LCA and skeletonization of the origin of IMA during laparoscopic colorectal resection. Read More

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http://dx.doi.org/10.7417/CT.2019.2121DOI Listing

Primary Tumor Site Affects Survival in Patients with Gastroenteropancreatic and Neuroendocrine Liver Metastases.

Int J Endocrinol 2019 12;2019:9871319. Epub 2019 Mar 12.

Division of General Surgery, Department of Surgery, The University of Chicago Medical Center, Chicago, IL, USA.

Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are commonly present with metastatic disease, and the liver is the most frequent metastatic site. Herein, we studied whether primary tumor site affects survival in patients with GEP-NETs and liver metastases (NELM). As a secondary endpoint, we studied whether extrahepatic disease and surgical resection impact survival in this patient population. Read More

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https://www.hindawi.com/journals/ije/2019/9871319/
Publisher Site
http://dx.doi.org/10.1155/2019/9871319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434277PMC
March 2019
2 Reads

Economic evaluation of the introduction of the Prostate Health Index as a rule-out test to avoid unnecessary biopsies in men with prostate specific antigen levels of 4-10 in Hong Kong.

PLoS One 2019 16;14(4):e0215279. Epub 2019 Apr 16.

Health Economics and Health Technology Assessment, Institute of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom.

A recent study showed that the Prostate Health Index may avoid unnecessary biopsies in men with prostate specific antigen 4-10ng/ml and normal digital rectal examination in the diagnosis of prostate cancer in Hong Kong. This study aimed to conduct an economic evaluation of the impact of adopting this commercially-available test in the Hong Kong public health service to determine whether further research is justified. A cost-consequence analysis was undertaken comparing the current diagnostic pathway with a proposed diagnostic pathway using the Prostate Health Index. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215279PLOS

A retrospective comparison of trans-rectal and trans-perineal prostate biopsies: experience of a single surgeon.

J Endourol 2019 Apr 16. Epub 2019 Apr 16.

Royal Melbourne Hospital, 90134, Melbourne, Australia.

Background: Transrectal ultrasound-guided biopsy (TRUS) is the gold standard for undertaking prostate biopsy however it has been associated with higher rates of post-biopsy sepsis than transperineal biopsy (TP).

Objective: To compare complication rates between transrectal prostate biopsy and transperineal biopsy for a single surgeon.

Material And Methods: Data were collected for all prostate biopsies undertaken by a single experienced urologist through his private rooms between February 2012 and March 2018. Read More

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http://dx.doi.org/10.1089/end.2019.0170DOI Listing

Oncologic Outcomes of Self-Expandable Metallic Stent as a Bridge to Surgery and Safety and Feasibility of Minimally Invasive Surgery for Acute Malignant Colonic Obstruction.

Ann Surg Oncol 2019 Apr 15. Epub 2019 Apr 15.

Division of Colon and Rectal Surgery, Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background: Although self-expandable metal stents (SEMS) are widely used as a bridge to surgery (BTS) in patients with malignant colorectal cancer obstruction, there has been some debate about their effect on long-term oncological outcomes. Furthermore, data on the safety and feasibility of minimally invasive surgery (MIS) combined with stent placement are scarce. We aimed to determine the long-term oncological outcomes of SEMS as a BTS, and the short-term outcomes of SEMS used with minimally invasive colorectal surgery. Read More

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http://dx.doi.org/10.1245/s10434-019-07346-3DOI Listing
April 2019
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Long-term survival after adrenal metastasectomy from colorectal cancer: a report of two cases.

Surg Case Rep 2019 Apr 15;5(1):61. Epub 2019 Apr 15.

Department of Surgery, Nara Medical University, 840 Shijo-Cho, Kashihara, Nara, 634-8522, Japan.

Background: Solitary adrenal metastasis from colorectal cancer is rare. Adrenal metastasis is usually detected with synchronous multiple metastases in other organs and is, therefore, considered to be unsuitable for surgical resection. The long-term outcomes of patients with solitary adrenal metastasectomy from colorectal cancer have been reported; however, the survival advantage has not been established. Read More

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http://dx.doi.org/10.1186/s40792-019-0611-zDOI Listing
April 2019
4 Reads

The effectiveness and safety of open versus laparoscopic surgery for rectal cancer after preoperative chemo-radiotherapy: a meta-analysis.

Comb Chem High Throughput Screen 2019 Apr 14. Epub 2019 Apr 14.

Department of Oncology, Longyan First Hospital, Affiliated to Fujian Medical University, Longyan 364000. China.

Background: Only a limited number of studies considered the combined chemo-radiation therapy after surgery for treating locally advanced rectal cancer. Comparative studies on laparoscopic and open procedures indicated that laparoscopy surgery may be associated with fewer postoperative complications. Despite encouraging results from rectal cancer patients who received neo-adjuvant chemo-radiotherapy prior to laparoscopic surgery, the acceptance of this procedure remains controversial, and conflicting evidence exists only in the form of retrospective trials. Read More

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http://dx.doi.org/10.2174/1386207322666190415102505DOI Listing
April 2019
1 Read

Usability of rectal swabs for microbiome sampling in a cohort study of hematological and oncological patients.

PLoS One 2019 15;14(4):e0215428. Epub 2019 Apr 15.

University of Cologne, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.

Objectives: Large-scale clinical studies investigating associations between intestinal microbiota signatures and human diseases usually rely on stool samples. However, the timing of repeated stool sample collection cannot be predefined in longitudinal settings. Rectal swabs, being straightforward to obtain, have the potential to overcome this drawback. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215428PLOS
April 2019
2 Reads

Solitary adrenal metastasis from advanced gastric cancer invading duodenal bulb with situs inversus totalis: A case report.

Medicine (Baltimore) 2019 Apr;98(15):e15244

Department of the General Surgery.

Rationale: Situs invsersus totalis (SIT) is a rare anomaly featured by complete inversion of abdominal and thoracic organs. Adrenal metastasis is often encountered as part of advanced systemic dissemination, which is usually unresectable. Few published cases reported the adrenal metastasis from gastric cancer with SIT and the treatment of gastrectomy combined with adrenalectomy, especially with intraoperative radiotherapy (IORT). Read More

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http://dx.doi.org/10.1097/MD.0000000000015244DOI Listing
April 2019
1 Read

Ureteral Stone Mimicking Abnormal Sacral Uptake on 99mTc MDP Bone Scintigraphy: The Usefulness of SPECT/CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

From the Department of Nuclear Medicine, China-Japan Union Hospital, Changchun, Jilin, China.

Bone tracer uptake related to ureteral stones has been reported several times before. We present a right ureteral stone mimicking abnormal focal sacral uptake on planar scan in a patient with rectal cancer. This case highlights the necessity of performing SPECT/CT to ascertain the origin of abnormal focal sacral uptake on planar scan, especially in patients with a history of kidney stones. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002576DOI Listing

Isolated Vaginal Recurrence of Early-Stage Rectal Cancer Detected by 18F-FDG PET/CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Department of Nuclear Medicine, Chongqing Three Gorges Central Hospital, Chongqing, China.

The relapses of rectal cancer are most frequently localized in the pelvis, liver, and pelvic and para-aortic lymph nodes and lungs, whereas the vagina is an unusual site. We present here a 60-year-old woman presenting with lower abdominal discomfort 23 months after radical resection of rectal adenocarcinoma. An isolated, solitary, hypermetabolic mass in the right part of the vagina was detected by F-FDG PET/CT. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002573DOI Listing
April 2019
1 Read

Neoadjuvant Radiochemotherapy Significantly Alters the Phenotype of Plasmacytoid Dendritic Cells and 6-Sulfo LacNAc Monocytes in Rectal Cancer.

Front Immunol 2019 29;10:602. Epub 2019 Mar 29.

Institute of Immunology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Neoadjuvant radiochemotherapy (nRCT) can significantly influence the tumor immune architecture that plays a pivotal role in regulating tumor growth. Whereas, various studies have investigated the effect of nRCT on tumor-infiltrating T cells, little is known about its impact on the frequency and activation status of human dendritic cells (DCs). Plasmacytoid DCs (pDCs) essentially contribute to the regulation of innate and adaptive immunity and may profoundly influence tumor progression. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450462PMC
March 2019
1 Read

Determination of Optimal Clinical Target Volume to Planning Target Volume Margins for Conformal Radiotherapy Planning using Image Guidance System in Rectal Cancer in Prone Position.

J Med Phys 2019 Jan-Mar;44(1):65-67

Department of Radiotherapy, Dr. Bhubaneshwar Borooah Cancer Institute, Guwahati, Assam, India.

Context: In advanced radiotherapy techniques such as three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT), geometrical uncertainties are very crucial as they may lead to under dosing of tumor and over dosing of the nearby critical structures and hence, it is important to determine planning target volume (PTV) margins which are specific for every center.

Aims: The aim of this study is to determine adequate clinical target volume (CTV) to PTV margins specific to our radiotherapy center.

Settings And Design: To calculate CTV to PTV margins for rectal cancer patients in prone position using kV cone beam CBCT data sets. Read More

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http://dx.doi.org/10.4103/jmp.JMP_74_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438049PMC
April 2019
1 Read

[Main traps in proctology].

Rev Prat 2019 Jan;69(1):67-70

Maison de santé protestante de Bordeaux-Bagatelle, Talence, France.

Main traps in proctology. Traps are numerous in proctology. Avoiding the clinical examination is the most common. Read More

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January 2019
3 Reads

Laparoscopic sphincter reconstruction after abdominoperineal resection: feasibility and technical aspects.

Tech Coloproctol 2019 Apr 15. Epub 2019 Apr 15.

Department of General and Visceral Surgery, Brandenburg Medical School, University Hospital Neuruppin, Neuruppin, Germany.

Background: Abdominal colostomy has been reported as an option with good quality of life for patients requiring abdominoperineal resection (APR) for very low rectal cancer. Some young, compliant patients, nevertheless, are very motivated to avoid abdominal colostomy following APR. Spiral smooth muscle cuff perineal colostomy as neosphincter reconstruction can be a reasonable alternative. Read More

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http://dx.doi.org/10.1007/s10151-019-01962-7DOI Listing

Use of a linear stapler for urethral and dorsal vein complex transection during laparoscopic total pelvic exenteration in rectal cancer.

Tech Coloproctol 2019 Apr 15. Epub 2019 Apr 15.

Department of Gastrointestinal Surgery, Faculty of Medicine, Kagawa University, Miki-cho, Kagawa, Japan.

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http://link.springer.com/10.1007/s10151-019-01974-3
Publisher Site
http://dx.doi.org/10.1007/s10151-019-01974-3DOI Listing
April 2019
2 Reads

RAB27B-activated secretion of stem-like tumor exosomes delivers the biomarker microRNA-146a-5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer.

Int J Cancer 2019 Apr 13. Epub 2019 Apr 13.

Cancer Progression Center of Excellence, National Yang-Ming University, Taipei, Taiwan.

The dynamic cell-cell communication is essential for tissue homeostasis in normal physiological circumstances and contributes to a diversified tumor microenvironment (TME). Although exosomes are extracellular vesicles (EVs) that actively participate in cell-cell interaction by shutting cellular components, impacts of tumor exosomes in the context of cancer stemness remain elusive. Here, we expand colorectal cancer stem cells (CRCSCs) as cancer spheroids and demonstrate that the β-catenin/Tcf-4-activated RAB27B expression is required for the secretion of CRCSC exosomes. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32338
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http://dx.doi.org/10.1002/ijc.32338DOI Listing
April 2019
3 Reads

Laparoscopic Ovarian Transposition Before Pelvic Chemo-radiotherapy in a Young Female Patient with Rectal Cancer - A Video Vignette.

Colorectal Dis 2019 Apr 13. Epub 2019 Apr 13.

Colorrectal Sugery Unit, Donostia University Hospital.

In this video, we describe bilateral laparoscopic ovarian transposition (OT) as an alternative surgical approach for ovarian hormonal function preservation prior to pelvic chemo-radiotherapy for rectal cancer. A 29 years old woman presented with rectal bleeding, progressive tenesmus and frequency of defaecation. Colonoscopy revealed a concentric ulcerated rectal mass and histological examination confirmed the diagnosis of a rectal adenocarcinoma. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/codi.14644
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http://dx.doi.org/10.1111/codi.14644DOI Listing
April 2019
2 Reads

Laparoscopic Ultra Low Anterior Resection With Intracorporeal Coloanal Stapled Anastomosis for Low Rectal Cancer - Do We Always Need Robotic Surgery or TaTME to Achieve a Good Oncological And Sphincter Sparing Dissection? - a Video Vignette.

Colorectal Dis 2019 Apr 12. Epub 2019 Apr 12.

Department of Surgery, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK.

A great debate is currently undergoing regarding the best surgical approach for ultra low rectal cancer. TaTME is an increasingly used technique and an emerging alternative. However, its use should probably be limited to selected cases with specific indications. Read More

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http://dx.doi.org/10.1111/codi.14642DOI Listing

Rectal Endoscopic Ultrasound in Clinical Practice.

Curr Gastroenterol Rep 2019 Apr 12;21(4):18. Epub 2019 Apr 12.

Division of Gastroenterology, Washington University School of Medicine, 660 South Euclid Ave., Campus Box 8124, Saint Louis, MO, 63110, USA.

Purpose Of Review: Endoscopic ultrasound (EUS) is routinely utilized for evaluation of disorders of the lower gastrointestinal tract. In this review, we summarize the current status of rectal EUS in clinical practice and describe recent developments in diagnostic and therapeutic rectal EUS.

Recent Findings: Recent guidelines recommend rectal EUS for rectal cancer staging as a second line modality in cases where MRI is contraindicated. Read More

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http://dx.doi.org/10.1007/s11894-019-0682-9DOI Listing
April 2019
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Genome-wide RNAi screening identifies RFC4 as a factor that mediates radioresistance in colorectal cancer by facilitating non-homologous end joining repair.

Clin Cancer Res 2019 Apr 12. Epub 2019 Apr 12.

State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center

Purpose: Neoadjuvant chemoradiotherapy (neoCRT) is a standard treatment for locally advanced rectal cancer (LARC); however, resistance to chemoradiotherapy (CRT) is one of the main obstacles to improving treatment outcomes. The goal of this study was to identify factors involved in the radioresistance of CRC and to clarify the underlying mechanisms.

Experimental Design: A genome-wide RNAi screen was employed to search for candidate radioresistance genes. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3735DOI Listing

Cost-effectiveness of Short-Course Radiation Therapy vs Long-Course Chemoradiation for Locally Advanced Rectal Cancer.

JAMA Netw Open 2019 Apr 5;2(4):e192249. Epub 2019 Apr 5.

Department of Radiation Oncology, Massachusetts General Hospital, Boston.

Importance: Although both short-course radiotherapy and long-course chemoradiotherapy have been practiced in parallel for more than 15 years, no cost-effectiveness analysis comparing these 2 approaches in patients with locally advanced rectal cancer has been published.

Objective: To analyze the cost-effectiveness of short-course radiotherapy vs long-course chemoradiotherapy for the treatment of patients with locally advanced rectal cancer.

Design, Setting, And Participants: This economic evaluation used a cost-effectiveness model simulating 10-year outcomes for 1 million hypothetical patients aged 65 years with locally advanced rectal cancer treated with either short-course radiotherapy or long-course chemoradiotherapy, followed by surgery and chemotherapy. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.2249DOI Listing

Robotic abdominoperineal resection for pT2N0M0 low rectal cancer using Senhance Transenterix robotic platform - video vignette.

Colorectal Dis 2019 Apr 12. Epub 2019 Apr 12.

Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, 1 Santariskiu Str., Vilnius, LT-08406, Lithuania.

All previous studies which have described the possible benefits of robotic surgery have all used the Da Vinci system [1-3]. We present the first abdominoperineal resection for low rectal cancer using the Senhance Transenterix robotic platform. This article is protected by copyright. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/codi.14638
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http://dx.doi.org/10.1111/codi.14638DOI Listing
April 2019
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Low Incidence of Pelvic Sepsis after Hartmann's Procedure: Radiation Therapy May Be a Risk Factor.

Gastrointest Tumors 2019 Feb 5;5(3-4):77-81. Epub 2018 Nov 5.

Colorectal Unit, Department of Surgery, SUS Malmö, Malmö, Sweden.

Purpose: Hartmann's procedure is a well-established alternative in colorectal surgery when a primary anastomosis is contraindicated. However, the rectal remnant may cause complications. This study was designed to investigate the occurrence of pelvic sepsis after Hartmann's procedure and identify possible risk factors. Read More

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http://dx.doi.org/10.1159/000493526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422152PMC
February 2019
1 Read

Association between oncogenic RAS mutation and radiologic-pathologic findings in patients with primary rectal cancer.

Quant Imaging Med Surg 2019 Feb;9(2):238-246

Department of Radiology, Inje University College of Medicine, Haeundae Paik Hospital, Haeundae-gu, Busan, Korea.

Background: To evaluate the association between various radiologic-pathologic findings and oncogenic Kirsten-ras (KRAS) mutation in patients with primary rectal cancer.

Methods: Seventy-five patients with primary rectal cancer who had undergone rectal magnetic resonance imaging (MRI) were included. The rectal MRI consisted of T2-weighted images in three planes, pre- and post-contrast-enhanced T1-weighted images, and axial diffusion-weighted images (b factors, 0, 1,000 s/mm). Read More

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http://dx.doi.org/10.21037/qims.2018.12.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414762PMC
February 2019
1 Read

Association and diagnostic value of serum SPINK4 in colorectal cancer.

PeerJ 2019 4;7:e6679. Epub 2019 Apr 4.

Department of Research, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, P.R. China.

The role of serum serine peptidase inhibitor, Kazal type 4 (SPINK4), in colorectal cancer (CRC) is largely unknown. This study aimed to explore the association and diagnostic value of serum SPINK4 in CRC. A total of 70 preoperative CRC patients, 30 postoperative CRC patients, 30 gastric cancer patients, and 30 healthy controls were enrolled. Read More

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http://dx.doi.org/10.7717/peerj.6679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451835PMC
April 2019
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Radiation-induced injury on surgical margins: a clue to anastomotic leakage after rectal-cancer resection with neoadjuvant chemoradiotherapy?

Gastroenterol Rep (Oxf) 2019 Apr 11;7(2):98-106. Epub 2018 Dec 11.

Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China.

Background: Few studies on anastomotic condition after rectal-cancer resection and its effect on anastomotic leakage (AL) are available up to now. This study aimed to investigate potential radiation-induced injury left on surgical margins of anterior resection after neoadjuvant chemoradiotherapy (nCRT) and its association with AL.

Methods: We retrospectively identified 161 consecutive patients who underwent anterior resection with nCRT, neoadjuvant chemotherapy without radiation (nCT) or no neoadjuvant therapy between 2014 and 2015. Read More

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http://dx.doi.org/10.1093/gastro/goy042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454846PMC
April 2019
1 Read

Erratum to: Enhanced Recovery After Surgery Interactive Audit System: 10 Years' Experience with an International Web-Based Clinical and Research Perioperative Care Database.

Clin Colon Rectal Surg 2019 Jan 28;32(1):e1. Epub 2019 Feb 28.

Department of Surgery, Örebro University Hospital, Örebro, Sweden.

[This corrects the article DOI: 10.1055/s-0038-1673357.]. Read More

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http://dx.doi.org/10.1055/s-0039-1678573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458023PMC
January 2019
2 Reads