264 results match your criteria Recent Patents on Inflammation & Allergy Drug Discovery [Journal]


Lyme Neuroborreliosis - The Mystifying Pitfall: "Neuropathology and Current Therapeutics".

Recent Pat Antiinfect Drug Discov 2019 Mar 26. Epub 2019 Mar 26.

Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmadabad, Gujarat-382481. India.

Lyme's Disease (LD) is a severe rapidly growing broad spectrum chronic infection caused by the bacterium 'Borrelia (B.) burgdoferi', which can be easily transmitted through the bite of certain species of ticks. The prevalence of LD is swiftly mounting in present scenario in many countries from species to species. Read More

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http://dx.doi.org/10.2174/1574891X14666190327114641DOI Listing
March 2019
1 Read

Marine natural products as source of new drugs: a patent review (2015-2018).

Expert Opin Ther Pat 2019 Apr 3;29(4):283-309. Epub 2019 Apr 3.

a CSIR Unit for Research and Development of Information Products (CSIR-URDIP) , Pune , India.

Introduction: Natural products from plants, animals, microbes, and minerals have long been a traditional source for the treatment of human diseases. In the past decades, research on natural products for the pharmaceutical industry had declined due to numerous challenges. However, the recent developments in analytical technology, spectroscopy, and high-throughput screening have tremendously revived natural product drug discovery, including contribution from marine-based drugs. Read More

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http://dx.doi.org/10.1080/13543776.2019.1598972DOI Listing
April 2019
2 Reads

Discovery of new depigmenting compounds and their efficacy to treat hyperpigmentation: Evidence from in vitro study.

J Cosmet Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Malaysia.

Human skin pigmentation is a result of constitutive and facultative pigmentation. Facultative pigmentation is frequently stimulated by UV radiation, pharmacologic drugs, and hormones whereby leads to the development of abnormal skin hyperpigmentation. To date, many state-of-art depigmenting compounds have been studied using in vitro model to treat hyperpigmentation problems for cosmetic dermatological applications; little attention has been made to compare the effectiveness of these depigmenting compounds and their mode of actions. Read More

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http://dx.doi.org/10.1111/jocd.12900DOI Listing
March 2019
2 Reads
1.000 Impact Factor

Bilayer Tablet Based Chronotherapeutics in the Management of Nocturnal Asthma: An Overview.

Recent Pat Drug Deliv Formul 2019 Feb 27. Epub 2019 Feb 27.

Abbott Healthcare Private Limited, Baddi (Himachal Pradesh), . India.

Background And Aim: Asthma is a common ailment having larger circadian difference. The nocturnal asthma (NA) is inconstant exacerbation of asthma condition related to the rises in warning sign at night and there is need for treatment, air route alertness, and/or falling of lung role. These symptoms are linked to sleep or known as circadian events. Read More

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http://dx.doi.org/10.2174/1872211313666190227204127DOI Listing
February 2019
2 Reads

Enterococcus faecalis EF-2001 protects DNBS-induced inflammatory bowel disease in mice model.

PLoS One 2019 28;14(2):e0210854. Epub 2019 Feb 28.

Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University, Chungju, Republic of Korea.

Recent studies have demonstrated the immunomodulatory effects of heat-killed lactic acid bacteria. The aim of this study was to evaluate the protective effect of heat-killed Enterococcus faecalis EF-2001 (EF-2001) on a model of inflammatory bowel disease (IBD). A total of 28 female NC/Nga mice were divided into 4 treatment groups. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210854PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394946PMC
February 2019
1 Read

Ammonia sensing and cytotoxicity of biosynthesized silver nanoparticle by Arabic Gum (AG).

Recent Pat Biotechnol 2019 Jan 18. Epub 2019 Jan 18.

Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad. Iran.

Background: The green synthesizing procedure of Silver nanoparticles (AgNPs) has been performed through the usage of a natural polysaccharide; Arabic gum (AG) as a stabilizing/capping agent. For characterization of AgNPs, TEM, particle size analyzer and UV-Vis were used.

Methods: The aim of our project was to identify biosynthesized AgNPs for sensing ammonia and to explore its toxicity on Neuro-2A cells. Read More

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http://www.eurekaselect.com/169123/article
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http://dx.doi.org/10.2174/1872208313666190118123141DOI Listing
January 2019
9 Reads

Purinergic P2X7 Receptor: A Cation Channel Sensitive to Tumor Microenvironment.

Recent Pat Anticancer Drug Discov 2019 ;14(1):32-38

Department of Life Sciences and Systems Biology, University of Torino, Torino, Italy.

Background: Purinergic signalling is involved in several physiological and pathophysiological processes. P2X7 Receptor (P2X7R) is a calcium-permeable ion channel that is gaining interest as a potential therapeutic target for the treatment of different diseases including inflammation, pain, psychiatric disorders and cancer. P2X7R is ubiquitously expressed and sensitive to high ATP levels, usually found in tumor microenvironment. Read More

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http://dx.doi.org/10.2174/1574892814666190116122256DOI Listing
January 2019
1 Read

Anti-Arthritic Effect of Garcinol Enriched Fraction Against Adjuvant Induced Arthritis.

Recent Pat Inflamm Allergy Drug Discov 2018 Nov 19. Epub 2018 Nov 19.

SPP- School of Pharmacy and Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400056, Maharashtra. India.

Background: Garcinia indica also known as kokum is used in traditional system of medicine for relieving inflammation and rheumatic pain. Garcinol, a benzophenone obtained from its fruit rind is reported to have anti-inflammatory effect via modulating arachidonic acid metabolism, suppressing iNOS expression, NF-κB activation and COX-2 expression. It has also been studied for antioxidant and anticancer activity. Read More

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http://dx.doi.org/10.2174/1872213X12666181120091528DOI Listing
November 2018
13 Reads

Therapeutic potential of tranilast for the treatment of chronic graft-versus-host disease in mice.

PLoS One 2018 11;13(10):e0203742. Epub 2018 Oct 11.

Deaprtment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.

Chronic graft-versus-host disease (cGVHD) is a marked complication of hematopoietic stem cell transplantation, and multiple organs can be affected by cGVHD-induced inflammation and fibrosis. In clinical settings, immunosuppressive agents have been the last resort to treat cGVHD. However, it has been only partially effective for cGVHD. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203742PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181285PMC
March 2019
3 Reads

Biotechnological Applications of Serine Proteases: A Patent Review.

Recent Pat Biotechnol 2018 ;12(4):280-287

UMR 1319 Micalis, INRA, AgroParisTech, Universite Paris-Saclay, Microbiota Interaction with Human and Animal Team, 78350, Jouy-en-Josas, France.

Background: Serine proteases have long been recognized to play key roles in various physiological processes. However, their disequilibrium can be linked to several diseases. Taking into account their wide diversity and specificity, they have been actively investigated by many industrial, academic and pharmaceutical industries. Read More

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http://www.eurekaselect.com/165586/article
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http://dx.doi.org/10.2174/1872208312666180924112007DOI Listing
January 2019
3 Reads

Biosimilars in oncology and inflammatory diseases: current and future considerations for clinicians in Latin America.

MAbs 2018 Aug/Sep;10(6):827-842. Epub 2018 Aug 29.

g Pfizer Inc , New York , NY , USA.

Biological therapies have revolutionized the treatment of several cancers and systemic immune-mediated inflammatory conditions. Expiry of patents protecting a number of biologics has provided the opportunity to commercialize highly similar versions, known as biosimilars. Biosimilars are approved by regulatory agencies via an independent pathway that requires extensive head-to-head comparison with the originator product. Read More

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https://www.tandfonline.com/doi/full/10.1080/19420862.2018.1
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http://dx.doi.org/10.1080/19420862.2018.1484977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152448PMC
February 2019
21 Reads

Prevention of Cardiovascular Diseases with Anti-Inflammatory and Anti- Oxidant Nutraceuticals and Herbal Products: An Overview of Pre-Clinical and Clinical Studies.

Recent Pat Inflamm Allergy Drug Discov 2018 ;12(2):145-157

Department of Pharmaceutical Sciences, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM`S NMIMS, Mumbai- 400056, India.

Background: Inflammation-induced endothelial abnormalities, dietary habits, and tobacco smoking are considered to be the primary risk factors for causing atherosclerosis and Cardiovascular Diseases (CVDs), including Coronary Heart Disease (CHD), cerebrovascular disorders, peripheral arterial disease, rheumatic heart disease, congenital heart defects, deep vein thrombosis and pulmonary embolism. Prevention of CVDs with anti-inflammatory and anti-oxidant agents has been a challenging task for decades. Currently, CVDs have taken a top position among the health-related issues and are considered the foremost cause of mortality and morbidity around the globe. Read More

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http://dx.doi.org/10.2174/1872213X12666180815144803DOI Listing
December 2018
8 Reads

A Fixed Combination of Probiotics and Herbal Extracts Attenuates Intestinal Barrier Dysfunction from Inflammatory Stress in an In vitro Model Using Caco-2 Cells.

Recent Pat Food Nutr Agric 2019 ;10(1):62-69

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.

Background: Inflammatory Bowel Diseases (IBD), are considered a growing global disease, with about ten million people being affected worldwide. Maintenance of intestinal barrier integrity is crucial for preventing IBD onset and exacerbations. Some recent patents regarding oily formulations containing probiotics (WO2010122107A1 and WO2010103374A9) and the use of probiotics for gastrointestinal complaints (US20110110905A1 and US9057112B2) exist, or are pending application. Read More

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http://dx.doi.org/10.2174/2212798410666180808121328DOI Listing
March 2019
152 Reads

Role of Curcumin in Regulation of TNF-α Mediated Brain Inflammatory Responses.

Recent Pat Inflamm Allergy Drug Discov 2018 ;12(1):69-77

Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.) - 495009, India.

Background: Inflammation is a protective response of the body system that protects the body from the various kinds of external and internal insults; however, it has been found that most chronic illnesses are caused by dysregulated and excessive inflammation. Inflammation plays a major role in developing neurological diseases. In the brain cytokines, TNF-α and TNF-β are known to mediate inflammation in many diseases. Read More

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http://dx.doi.org/10.2174/1872213X12666180703163824DOI Listing
December 2018
8 Reads

Effect of Prolonged Anti-HM1: IMSS Entamoeba histolytica Antibody Activity in Humoral and Cellular Immunity of Experimentally Induced Animal Model.

Recent Pat Inflamm Allergy Drug Discov 2018 ;12(1):87-95

Department of Microbiology, Barkatullah University, Bhopal-462026, Madhya Pradesh, India.

Background: The Cellular immunity plays an important role in amoebic infections, whereas humoral immune responses have little influence on the outcome of the disease. Chronic infestation with Entameoba histolytica, a common protozoan parasite, has been associated with autoimmune phenomena, including the appearance of antibodies to colonic epithelial cells. The mechanism whereby the protozoan parasite E. Read More

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http://dx.doi.org/10.2174/1872213X12666180621164732DOI Listing
December 2018
7 Reads

Latest in Vitro and in Vivo Assay, Clinical Trials and Patents in Cancer Treatment using Curcumin: A Literature Review.

Nutr Cancer 2018 May-Jun;70(4):569-578. Epub 2018 Apr 30.

b Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada , Granada , Spain.

Curcumin, the main active compound of the curcuma root, shows antioxidant, anti-inflammatory, and antitumor properties which have been demonstrated in preclinical and clinical trials. Its antitumor activity is mediated by its ability to act directly on the tumor cell, activating apoptosis pathways and indirectly inhibiting the process of inflammation, angiogenesis, and metastasis in the tumor microenvironment. In addition, it has a preventive activity such as radio and/or chemosensitizer. Read More

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http://dx.doi.org/10.1080/01635581.2018.1464347DOI Listing
February 2019
6 Reads

Flow Cytometric Analysis of Pro-inflammatory Cytokine Production in Hyperglycemic Mouse Model.

Recent Pat Food Nutr Agric 2018 ;9(2):119-126

Department of Immunology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.

Objective: The sharp increase of pro-inflammatory cytokine becomes a severe problem in some degenerative diseases. This study aimed to investigate the effect of Cherry Leaf Extract (CLE) on pro-inflammatory cytokine production in hyperglycaemic mouse model. A recent patent mentioned that Muntinga calabura is a flavonoid-containing plant which is capable of reinforcing the stomach, appetizing, helping digestion (CN 201611138374), and improving stomach distention (CN106071017A). Read More

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http://dx.doi.org/10.2174/2212798410666180426161016DOI Listing
January 2019
1 Read

In vitro And In vivo Immunomodulating Properties of Mesenchymal Stem Cells.

Recent Pat Inflamm Allergy Drug Discov 2018 ;12(1):59-68

Department of Biochemistry & Genetics, Barkatullah University, Bhopal 462 026, Madhya Pradesh, India.

Background: Mesenchymal Stem Cells (MSCs) are self-renewing, multipotent progenitor cells with multilineage potential to differentiate into all cell types of mesodermal origin, such as adipocytes, osteocytes and chondrocytes. Mesenchymal Stem Cells (MSCs) are adult stem cells which can be isolated from human and animal sources.

Objective: Besides the differentiation potential of MSCs, these also regulate the immune response in numerous ailments. Read More

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http://dx.doi.org/10.2174/1872213X12666180227105924DOI Listing
December 2018
2 Reads

Oral Submucous Fibrosis as an Overhealing Wound: Implications in Malignant Transformation.

Recent Pat Anticancer Drug Discov 2018 ;13(3):272-291

Department of Oral Pathology, Manipal College of Dental Sciences, Manipal University, Manipal - 576104, India.

Background: Oral submucous fibrosis is an oral potentially malignant disorder with high incidence of malignant transformation and rising global prevalence. However, the genesis of oral submucous fibrosis is still unclear despite superfluity of literature. In the background of ineffective treatment, it is necessary to decode its onset and progression before designing customized treatment regimens. Read More

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http://www.eurekaselect.com/160134/article
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http://dx.doi.org/10.2174/1574892813666180227103147DOI Listing
November 2018
26 Reads

An Overview of Hepatoprotective Effects of Thymoquinone.

Recent Pat Food Nutr Agric 2018 ;9(1):14-22

Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.

Background: Liver diseases are globally recognized as major medical problems. Several species of herbal medicine have been investigated for the management of liver-related diseases.

Objective: In this context, Thymoquinone (TQ) as the main constituent of Nigella sativa has long been focused for the treatment of liver diseases in recent years. Read More

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http://dx.doi.org/10.2174/2212798410666180221105503DOI Listing
October 2018
4 Reads

Novel Patents Targeting Interleukin-17A; Implications in Cancer and Inflammation.

Recent Pat Anticancer Drug Discov 2018 ;13(2):133-144

Group for Molecular Oncology, Institute for Medical Research, University of Belgrade, Dr. Subotica 4, 11129 Belgrade, Serbia.

Background: IL-17A is a founding member of the IL-17 family that has been implicated in the pathogenesis of inflammatory-associated diseases such as cancer and autoimmune disease. In cancer, IL-17A participates in many key events for tumor development, in part by affecting innate and adaptive immune system and also by direct modulation of many pro-tumor events. Moreover, IL-17A dysregulation at the site of inflammation is associated with rheumatoid arthritis, multiple sclerosis, psoriasis, among others. Read More

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http://www.eurekaselect.com/159948/article
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http://dx.doi.org/10.2174/1574892813666180220105958DOI Listing
October 2018
11 Reads

Anti-Inflammatory Drugs and Herbs with Special Emphasis on Herbal Medicines for Countering Inflammatory Diseases and Disorders - A Review.

Recent Pat Inflamm Allergy Drug Discov 2018 ;12(1):39-58

Tecnologico de Monterrey, School of Engineering and Sciences, Campus Monterrey, Ave. Eugenio Garza Sada 2501, Monterrey, N.L., CP 64849, Mexico.

Background: Diseases with inflammatory etiopathology have increased in incidence in recent times. Drugs used for therapeutic management of such inflammatory diseases are relieving the ailment but at the same time also countering serious life threatening consequences. Moreover, they are costly and rarely available at all places. Read More

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http://www.eurekaselect.com/159064/article
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http://dx.doi.org/10.2174/1872213X12666180115153635DOI Listing
December 2018
11 Reads

Recent progress in the use and tracking of transplanted islets as a personalized treatment for type 1 diabetes.

Expert Rev Precis Med Drug Dev 2017 13;2(1):57-67. Epub 2017 Mar 13.

Russell H. Morgan Department of Radiology, Division of Magnetic Resonance Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Introduction: Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the pancreas produces insufficient amounts of insulin. T1DM patients require exogenous sources of insulin to maintain euglycemia. Transplantation of naked or microencapsulated pancreatic islets represents an alternative paradigm to obtain an autonomous regulation of blood glucose levels in a controlled and personalized fashion. Read More

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http://dx.doi.org/10.1080/23808993.2017.1302305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737787PMC
March 2017
2 Reads

Natural Product Formulations for the Prevention and Treatment of Alzheimer's disease: A Patent Review.

Recent Pat Drug Deliv Formul 2018 ;12(1):23-39

Department of Medical Physics and Biophysics, Medical University-Sofia, Sofia, Bulgaria.

Introduction: Although considerable efforts have been made to develop effective therapeutic agents for Alzheimer's Disease (AD), neither a consensus concerning the pathogenesis of the disease nor a successful therapy for its treatment is yet available. The natural product chemistry brings tremendous diversity and abundant resource for medical needs.

Objectives: The present review summarizes recent patents on natural extracts and derived drugs as agents for the prevention and treatment of AD. Read More

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http://dx.doi.org/10.2174/1872211312666171207152326DOI Listing
October 2018
7 Reads

Thymoquinone a Potential Therapeutic Molecule from the Plant Nigella sativa: Role of Colloidal Carriers in its Effective Delivery.

Recent Pat Drug Deliv Formul 2018 ;12(1):3-22

University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh, India.

Background: From the past few decades, remarkable awareness has laid on the use of herbal medicines in pharmaceutical research. Thymoquinone (TQ), the main chemical constituent of Nigella Sativa (NS) plant, has been extensively explored, and revealed an array of therapeutic benefits, in different in vitro, and in vivo conditions. This review provides brief outline of the diverse therapeutics actions of TQ, and NS, viz. Read More

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http://dx.doi.org/10.2174/1872211311666171129121128DOI Listing
October 2018
19 Reads

Targeting Mevalonate Pathway in Cancer Treatment: Repurposing of Statins.

Recent Pat Anticancer Drug Discov 2018 ;13(2):184-200

Experimental Pharmacology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale - IRCCS, 80131 Naples, Italy.

Background: Modifications of lipid metabolism have been progressively accepted as a hallmark of tumor cells and in particular, an elevated lipogenesis has been described in various types of cancers.

Objective: Important or deregulated activity of the mevalonate pathway has been demonstrated in different tumors and a wide range of studies have suggested that tumor cells are more dependent on the unceasing availability of mevalonate pathway metabolites than their non-malignant complements.

Methods: This study provides an overview of the state of the art of statins treatment on human cancer. Read More

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http://dx.doi.org/10.2174/1574892812666171129141211DOI Listing
October 2018
7 Reads

Serine protease inhibitors to treat inflammation: a patent review (2011-2016).

Expert Opin Ther Pat 2018 02 5;28(2):93-110. Epub 2017 Dec 5.

a B2A, Biological Adaptation and Ageing, Integrated Cellular Ageing and Inflammation, Molecular & Functional Enzymology , Sorbonne Universités , UPMC Univ Paris 06, UMR 8256 , Paris , France.

Introduction: Inflammation is a physiological part of the complex biological response of tissues to counteract various harmful signals. This process involves diverse actors such as immune cells, blood vessels, and nerves as sources of mediators for inflammation control. Among them serine proteases are key elements in both physiological and pathological inflammation. Read More

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http://dx.doi.org/10.1080/13543776.2018.1406478DOI Listing
February 2018
8 Reads

Understanding the impact of hypoglycemia on the cardiovascular system.

Expert Rev Endocrinol Metab 2017 5;12(1):21-33. Epub 2017 Jan 5.

University of Maryland School of Medicine - Medicine, 22 S. Greene Street, Baltimore, Maryland 21201, United States.

Introduction: Hypoglycemia occurs commonly in insulin requiring individuals with either Type 1 or Type 2 Diabetes.

Areas Covered: This article will review recent information on the pro-inflammatory and pro-atherothrombotic effects of hypoglycemia. Additionally, effects of hypoglycemia on arrhythmogenic potential and arterial endothelial dysfunction will be discussed. Read More

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http://dx.doi.org/10.1080/17446651.2017.1275960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669378PMC
January 2017
2 Reads

NLRP3 Inflammasome Activation Inhibitors in Inflammation-Associated Cancer Immunotherapy: An Update on the Recent Patents.

Recent Pat Anticancer Drug Discov 2018 ;13(1):106-117

College of Biomedical and Health Sciences, Konkuk University, Chungju. Korea.

Background: Inflammasomes are recognized as key regulators in innate immunity from the pathogenic to endogenous danger signals. Although controlled activation of inflammasome is highly beneficial, dysregulation of inflammasome activation plays central role in various autoimmune, inflammatory disorders and aid in promoting various forms of cancers in humans such as breast cancer, fibrosarcoma, gastric carcinoma, and lung metastasis. NLRP3 inflammasome activation has been emerged as a topic of interest and is under profound investigation for its involvement in multiple forms of cancers. Read More

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http://dx.doi.org/10.2174/1574892812666171027102627DOI Listing
August 2018
16 Reads

Recent Patents and Emerging Therapeutics on Ocular Inflammation and Allergy.

Recent Pat Inflamm Allergy Drug Discov 2017 ;11(2):92-106

Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, 64108. United States.

Background: Ocular inflammation and allergic eye diseases range from mild to severe may disturb visual function and affect` quality of life. Since these diseases require intensive therapies, the pathophysiology and treatments of these conditions are highlighted.

Objective: The ocular diseases caused by inflammation and allergy are extensively studied in this review to provide an overview of the newer compounds, novel delivery approaches, preclinical and clinical trials for the treatment of allergic conjunctivitis, dry eye syndrome, and uveitis. Read More

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http://dx.doi.org/10.2174/1872213X11666170913150146DOI Listing
August 2018
29 Reads

A Review of Patents on Therapeutic Potential and Delivery of Hydroge n Sulfide.

Recent Pat Drug Deliv Formul 2017 ;11(2):114-123

Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University 68178, Omaha, Nebraska, NE. United States.

Background: Hydrogen sulfide (H2S) is a colorless gas with a characteristic smell of rotten eggs. Once only thought of as a toxic gas, evidence now shows that H2S plays major roles in pathological and physiological activities. These roles are being utilized to treat diseases and disorders ranging from hypertension, inflammation, edema, cardiovascular issues, chronic pain, cancer, and many more. Read More

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http://dx.doi.org/10.2174/1872211311666170911160914DOI Listing
August 2018
21 Reads

Emerging Role of CD44 Receptor as a Potential Target in Disease Diagnosis: A Patent Review.

Recent Pat Inflamm Allergy Drug Discov 2017 ;11(2):77-91

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi- 110 062. India.

Background: The CD44 receptor is a cell surface glycoprotein, which mediates many physiological and pathological activities. Its key role is to provide defence against inflammatory reactions by cellular transmigration and cell signalling. In pathological conditions, it gives destructive outcomes by mediating migration of pathogenic cells to vital organs resulting in tissue and organ damage. Read More

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http://dx.doi.org/10.2174/1872213X11666170907111858DOI Listing
August 2018
8 Reads

Acute Otitis Media in Children.

Recent Pat Inflamm Allergy Drug Discov 2017 ;11(1):32-40

Department of Family Medicine, The University of Calgary, Calgary, Alberta. Canada.

Background: Acute otitis media is a common childhood infection. Prompt diagnosis and appropriate treatment are very important.

Objective: To review in depth the epidemiology, pathophysiology, clinical manifestations, diagnosis, complications and particularly treatment of acute otitis media in children. Read More

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http://dx.doi.org/10.2174/1874609810666170712145332DOI Listing
November 2017
28 Reads

New Therapeutic Targets for Osteoarthritis Pain.

SLAS Discov 2017 Sep 6;22(8):931-949. Epub 2017 Jul 6.

1 Arthritis Research UK Pain Centre, University of Nottingham, UK.

Osteoarthritis (OA), the most common form of arthritis, causes pain and disability, as well as emotional distress. While total joint replacement is one of the most effective treatments available for improving the quality of life in people with severe OA, it is not suitable for all patients and all joints. Current pharmacological analgesics have limited efficacy, and their use is often restricted by adverse events. Read More

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http://dx.doi.org/10.1177/2472555217716912DOI Listing
September 2017
6 Reads

Bioactive Antimicrobial Peptides as Therapeutics for Corneal Wounds and Infections.

Adv Wound Care (New Rochelle) 2017 Jun;6(6):175-190

Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.

More than 2 million eye injuries and infections occur each year in the United States that leave civilians and military members with reduced or complete vision loss due to the lack of effective therapeutics. Severe ocular injuries and infections occur in varied settings including the home, workplace, and battlefields. In this review, we discuss the potential of developing antimicrobial peptides (AMPs) as therapeutics for the treatment of corneal wounds and infections for which the current treatment options are inadequate. Read More

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http://dx.doi.org/10.1089/wound.2016.0713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467138PMC
June 2017
2 Reads

Microdialysis-Assessed Adipose Tissue Metabolism in Critically Ill Patients.

Recent Pat Endocr Metab Immune Drug Discov 2017 ;11(1):32-38

Department of Experimental Physiology, National & Kapodistrian University of Athens, Athens, Greece.

Background: Microdialysis is a minimally invasive technique that allows direct in situ and in vivo sampling, studies and manipulations of the interstitial/extracellular fluid/space. It has been shown to be of use mainly in acute brain injury/neurocritical care.

Methods: Microdialysis has been used to study obesity, diabetes mellitus, inflammation and pharmacokinetics at the adipose tissue level. Read More

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http://dx.doi.org/10.2174/1872214811666170608114933DOI Listing
October 2018
6 Reads

Optimization of Microemulsion Based Transdermal Gel of Triamcinolone.

Recent Pat Antiinfect Drug Discov 2017 ;12(1):61-78

Department of Pharmaceutics, MAEER's Maharashtra Institute of Pharmacy, MIT Campus, S. No. 124, Kothrud, Pune 411038, Savitribai Phule Pune University, Pune. India.

Background: Triamcinolone is a long acting corticosteroid used in the treatment of arthritis, eczema, psoriasis and similar conditions which cause inflammation. Triamcinolone has half-life of 88min. Prolonged oral use is associated with gastrointestinal adverse effects as peptic ulcer, abdominal distention and ulcerative esophagitis as described in various patents. Read More

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http://dx.doi.org/10.2174/1574891X12666170426092911DOI Listing
June 2018
27 Reads

Evaluation of US 2016/0115161 A1: isoindoline compounds and methods of their use.

Expert Opin Ther Pat 2017 Jun;27(6):637-641

a The Chair of Pharmaceutical Chemistry , University of Ljubljana , Ljubljana , Slovenia.

Introduction: Immunomodulatory drugs (IMIDs®) are small orally available molecules that modulate the immune system and other biological targets through multiple mechanisms of action and have been successfully used in the treatment of myelodysplastic syndrome and multiple myeloma. However, recent studies of their complex mechanism of action revealed their potential in autoimmune diseases and solid tumors, which intensified scientific interest in these compounds. Areas covered: This patent application claims new IMIDs for the treatment of cancer and disorders associated with angiogenesis and inflammation. Read More

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http://dx.doi.org/10.1080/13543776.2017.1322954DOI Listing
June 2017
5 Reads

Autotaxin inhibitors: a patent review (2012-2016).

Expert Opin Ther Pat 2017 Jul 9;27(7):815-829. Epub 2017 May 9.

a Department of Chemistry , National and Kapodistrian University of Athens , Athens , Greece.

Introduction: Autotaxin (ATX) is a secreted enzyme that hydrolyzes lysophosphatidylcholine to lysophosphatidic acid (LPA) and choline. The ATX/LPA axis has received increasing interest in recent years because both the enzyme ATX and the bioactive lipid LPA are involved in various pathological conditions such as tumor progression and metastasis, fibrotic diseases, autoimmune diseases, arthritis, chronic hepatitis, obesity and impaired glucose homeostasis. Thus, a great effort has been devotd in developing synthetic ATX inhibitors as new agents to treat various diseases including cancer and fibrotic diseases. Read More

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http://dx.doi.org/10.1080/13543776.2017.1323331DOI Listing
July 2017
3 Reads

P2X7 antagonists for CNS indications: recent patent disclosures.

Pharm Pat Anal 2017 Mar 1;6(2):61-76. Epub 2017 Mar 1.

Axxam Discovery Research, Via Castellino, 111, 80100 Napoli, Italy.

P2X7, a ligand-gated purinergic ion channel, has been at the center of intense efforts in the pharmaceutical industry in the last 15 years due to the growing appreciation of its role in inflammation. Since 2008-2009, increased focus on CNS available compounds has led to the publication of various patents on behalf of several pharmaceutical companies. This patent review aims at analyzing the recent patent literature (2008-2016) with a particular emphasis on those patents that are thought to deal with CNS penetrant compounds on the basis of their physicochemical features, the assays described in the patents and the uses these compounds are claimed for. Read More

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http://dx.doi.org/10.4155/ppa-2016-0044DOI Listing
March 2017
29 Reads

Probiotics in Curing Allergic and Inflammatory Conditions - Research Progress and Futuristic Vision.

Recent Pat Inflamm Allergy Drug Discov 2017 ;10(2):105-118

Cellular Immunology Lab, Frank Reidy Research Center of Bioelectrics, College of Health Sciences, Old Dominion University, 4211 Monarch Way, IRP-2, Suite # 300 Norfolk, VA 23508. United States.

Background: Probiotics constitute the viable and beneficial microbes, which offer a dietary means to sustain the balance of gastro-intestinal (GI) microflora. Owing to their multiple health benefits, these have recently gained wide attention among researchers for exploring their potential in safeguarding the health of humans and animals. Probiotics could also modulate host-immune responses, thereby help in counteracting the immunological dysfunctions. Read More

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http://dx.doi.org/10.2174/1872213X10666161226162229DOI Listing
November 2017
16 Reads

Heat Shock Proteins: Therapeutic Perspectives in Inflammatory Disorders.

Recent Pat Inflamm Allergy Drug Discov 2017 ;10(2):94-104

Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly- 243 122, Uttar Pradesh. India.

Background: Heat shock proteins (HSPs) are highly conserved proteins present in all kingdoms of organisms. These are expressed under stress conditions in order to protect the cells from injuries. The stress induced protein denaturation is rectified by refolding and remodelling. Read More

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http://dx.doi.org/10.2174/1872213X10666161213163301DOI Listing
November 2017
27 Reads

Inflammation in Chronic Wounds.

Int J Mol Sci 2016 Dec 11;17(12). Epub 2016 Dec 11.

Sutton Arthritis Research Laboratory, Kolling Institute of Medical Research, University of Sydney, NSW 2065, Australia.

Non-healing chronic wounds present a major biological, psychological, social, and financial burden on both individual patients and the broader health system. Pathologically extensive inflammation plays a major role in the disruption of the normal healing cascade. The causes of chronic wounds (venous, arterial, pressure, and diabetic ulcers) can be examined through a juxtaposition of normal healing and the rogue inflammatory response created by the common components within chronic wounds (ageing, hypoxia, ischaemia-reperfusion injury, and bacterial colonisation). Read More

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http://dx.doi.org/10.3390/ijms17122085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187885PMC
December 2016
25 Reads

Cytotoxicity and Anti-inflammatory Activity of Flavonoid Derivatives Targeting NF-kappaB.

Recent Pat Inflamm Allergy Drug Discov 2017 ;10(2):119-132

School of Pharmaceutical Sciences, Shoolini University, Bajhol, Solan-173229, (Himachal Pradesh). India.

Background: Nuclear factor-kappaB (NF-kappaB) has been reported to regulate various genes involved in cancer and inflammation. Accordingly, drugs inhibiting NF-kappaB may possess both anti-inflammatory and anticancer properties. So there is a need to discover novel compounds which should not only be a potential lead but also less toxic and cost effective. Read More

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http://dx.doi.org/10.2174/1872213X10666161114231625DOI Listing
November 2017
18 Reads

Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.

Expert Opin Ther Pat 2017 Feb 7;27(2):127-143. Epub 2016 Nov 7.

c AstraZeneca, Oncology iMED , Waltham , MA , USA.

Introduction: Janus kinases (JAKs) are a family of four enzymes; JAK1, JAK2, JAK3 and tyrosine kinase 2 (TYK2) that are critical in cytokine signalling and are strongly linked to both cancer and inflammatory diseases. There are currently two launched JAK inhibitors for the treatment of human conditions: tofacitinib for Rheumatoid arthritis (RA) and ruxolitinib for myeloproliferative neoplasms including intermediate or high risk myelofibrosis and polycythemia vera. Areas covered: This review covers patents claiming activity against one or more JAK family members in the period 2013-2015 inclusive, and covers 95 patents from 42 applicants, split over two parts. Read More

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http://dx.doi.org/10.1080/13543776.2017.1252753DOI Listing
February 2017
36 Reads

Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.

Expert Opin Ther Pat 2017 Feb 4;27(2):145-161. Epub 2016 Nov 4.

c AstraZeneca, Oncology iMED , Waltham , MA , USA.

Introduction: Janus kinases (JAKs) are a family of four enzymes; JAK1, JAK2, JAK3 and tyrosine kinase 2 (TYK2) that are critical in cytokine signalling and are strongly linked to both cancer and inflammatory diseases. There are currently two launched JAK inhibitors for the treatment of human conditions: tofacitinib for Rheumatoid arthritis (RA) and ruxolitinib for myeloproliferative neoplasms including intermediate or high risk myelofibrosis and polycythemia vera. Areas covered: This review covers patents claiming activity against one or more JAK family members in the period 2013-2015 inclusive, and covers 95 patents from 42 applicants, split over two parts. Read More

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http://dx.doi.org/10.1080/13543776.2017.1252754DOI Listing
February 2017
78 Reads

Necroptosis inhibitors as therapeutic targets in inflammation mediated disorders - a review of the current literature and patents.

Expert Opin Ther Pat 2016 Nov 8;26(11):1239-1256. Epub 2016 Sep 8.

a College of Biomedical and Health Sciences , Konkuk University , Chungju , Republic of Korea.

Introduction: Recent studies have shown substantial interplay between the apoptosis and necroptosis pathways. Necroptosis, a form of programmed cell death, has been found to stimulate the immune system contributing to the pathophysiology of several inflammation-mediated disorders. Determining the contribution of necroptotic signaling pathways to inflammation may lead to the development of selective and specific molecular target implicated necroptosis inhibitors. Read More

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http://dx.doi.org/10.1080/13543776.2016.1230201DOI Listing
November 2016
14 Reads

Ursolic Acid and Oleanolic Acid: Pentacyclic Terpenoids with Promising Anti-Inflammatory Activities.

Recent Pat Inflamm Allergy Drug Discov 2016 ;10(1):21-33

Department of Biotechnology, M. M. University, Mullana-Ambala Haryana-133207, India.

Background: Plant derived products are not only served as dietary components but also used to treat and prevent the inflammatory associated diseases like cancer. Among the natural products pentacyclic terpenoids including ursolic acid and oleanolic acid are considered as the promising anti-inflammatory therapeutic agents.

Objectives: The current review extensively discusses the anti-inflammatory therapeutic potential of these pentacyclic moieties along with their proposed mechanisms of action. Read More

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March 2017
64 Reads
21 Citations

Regulation of bone and cartilage by adenosine signaling.

Purinergic Signal 2016 12 29;12(4):583-593. Epub 2016 Jul 29.

Divisions of Rheumatology and Translational Medicine, Department of Medicine, School of Medicine, New York University, 550 First Avenue, MSB251, New York, NY, 10016, USA.

There is growing recognition that bone serves important endocrine and immunologic functions that are compromised in several disease states. While many factors are known to affect bone metabolism, recent attention has focused on investigating the role of purinergic signaling in bone formation and regulation. Adenosine is a purine nucleoside produced intracellularly and extracellularly in response to stimuli such as hypoxia and inflammation, which then interacts with P1 receptors. Read More

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http://dx.doi.org/10.1007/s11302-016-9527-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124004PMC
December 2016
5 Reads
5 Citations
3.890 Impact Factor

p38 Mitogen activated protein kinase (MAPK): a new therapeutic target for reducing the risk of adverse pregnancy outcomes.

Expert Opin Ther Targets 2016 Dec 4;20(12):1397-1412. Epub 2016 Aug 4.

b Department of Biochemistry and Molecular Biology , The University of Texas Medical Branch at Galveston , Galveston , TX , USA.

Introduction: Spontaneous preterm birth (PTB) and preterm premature rupture of the membranes (pPROM) remain as a major clinical and therapeutic problem for intervention and management. Current strategies, based on our knowledge of pathways of preterm labor, have only been effective, in part, due to major gaps in our existing knowledge of risks and risk specific pathways. Areas covered: Recent literature has identified physiologic aging of fetal tissues as a potential mechanistic feature of normal parturition. Read More

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http://dx.doi.org/10.1080/14728222.2016.1216980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182513PMC
December 2016
48 Reads