996,514 results match your criteria Recent Patents on Engineering [Journal]


Characterization of distinct mechanism of agonist-induced canine platelet activation.

J Vet Sci 2018 Dec 4. Epub 2018 Dec 4.

Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.

Platelet activation plays a major role in hemostasis and thrombosis. Various agonists including ADP and thrombin interact with GPCRs which transduce signals from the cell surface to intracellular effectors through various G proteins. Recent studies have elucidated the role of these receptors and their corresponding G proteins in the regulation of events involved in platelet activation. Read More

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December 2018
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[Current trends in flexible ureteroscopy: an update].

Aktuelle Urol 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg.

Flexible ureteroscopy (fURS) has become a success story in urology. Since its implementation into the treatment of urolithiasis, fURS has demonstrated excellent clinical performance and safety. In recent years, the spread of disposable ureteroscopes has shaped the field of endoscopic stone treatment. Read More

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December 2018
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Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions.

Endocr Rev 2018 Dec 12. Epub 2018 Dec 12.

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA.

Pancreatic islet transplantation has become an established approach to β-cell replacement therapy for the treatment of insulin deficient diabetes. Recent progress in techniques for islet isolation, islet culture, and peri-transplant management of the islet transplant recipient have resulted in substantial improvements in metabolic and safety outcomes for patients. For patients requiring total or sub-total pancreatectomy for benign disease of the pancreas, isolation of islets from the diseased pancreas with intrahepatic transplantation of autologous islets can prevent or ameliorate post-surgical diabetes, and for patients previously experiencing painful recurrent acute or chronic pancreatitis, quality-of-life is substantially improved. Read More

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December 2018
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Obese Patients Benefit, but do not Fare as Well as Nonobese Patients, Following Lumbar Spondylolisthesis Surgery: An Analysis of the Quality Outcomes Database.

Neurosurgery 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurological Surgery, University of California, San Francisco, California.

Background: Given recent differing findings following 2 randomized clinical trials on degenerative lumbar spondylolisthesis (DLS) surgery, there is a need to better define how subsets of patients fare following surgery.

Objective: To investigate the impact of obesity on patient-reported outcomes (PROs) following DLS surgery.

Methods: A total of 12 high-enrolling sites were queried, and we found 797 patients undergoing surgery for grade 1 DLS. Read More

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December 2018

Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial.

Am J Clin Nutr 2018 Dec;108(6):1249-1258

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, School of Medicine, Vanderbilt University, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.

Background: Previous in vitro and in vivo studies indicate that enzymes that synthesize and metabolize vitamin D are magnesium dependent. Recent observational studies found that magnesium intake significantly interacted with vitamin D in relation to vitamin D status and risk of mortality. According to NHANES, 79% of US adults do not meet their Recommended Dietary Allowance of magnesium. Read More

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December 2018

CASMAP: Detection of statistically significant combinations of SNPs in association mapping.

Bioinformatics 2018 Dec 12. Epub 2018 Dec 12.

Department of Biosystems Science and Engineering, ETH Zurich, Basel, 4058, Switzerland SIB Swiss Institute of Bioinformatics.

Summary: Combinatorial association mapping aims to assess the statistical association of higher-order interactions between genetic markers with a phenotype of interest. This paper presents CASMAP, a software package that leverages recent advances in significant pattern mining to overcome the statistical and computational challenges that have hindered combinatorial association mapping. CASMAP can be used to perform region-based association studies and to detect higher-order epistatic interactions of genetic variants. Read More

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December 2018

Sexual mixing in opposite-sex partnerships in Britain and its implications for STI risk: findings from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3).

Int J Epidemiol 2018 Dec 11. Epub 2018 Dec 11.

Institute for Global Health, University College London, London, UK.

Background: The extent to which individuals are similar to their sexual partners influences STI-transmission probabilities, yet there is a dearth of empirical data, especially those representative of the population.

Methods: Analyses of data reported by 10 759 sexually active people aged 16-74 y interviewed for a British national probability survey undertaken in 2010-12. Computer-assisted self-interviews asked about partner numbers and characteristics of participants' three most recent partnerships (MRPs). Read More

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December 2018

Perspectives on the Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Biomedical Research.

Stem Cell Reports 2018 Dec;11(6):1306-1311

Department of Anatomy and Embryology, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, the Netherlands. Electronic address:

Cardiovascular disease is still a major cause of ill-health and mortality, heart failure and arrhythmia being among the causes of sudden cardiac death. There are few drugs available for treatment or prevention and it remains difficult to predict who will develop these conditions, even when disease-causing mutations or associated gene variants are identified in individuals or families. This is in part because widely used rodent models may not fully capture the physiology of the human heart. Read More

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December 2018

Conformational stability and dynamics of the cancer-associated isoform Δ133p53β are modulated by p53 peptides and p53-specific DNA.

FASEB J 2018 Dec 12:fj201801973R. Epub 2018 Dec 12.

Basic Science Program, Leidos Biomedical Research, Inc., Cancer and Inflammation Program, National Cancer Institute, Frederick, Maryland, USA; and.

p53 is a tumor suppressor protein that maintains genome stability, but its Δ133p53β and Δ160p53β isoforms promote breast cancer cell invasion. The sequence truncations in the p53 core domain raise key questions related to their physicochemical properties, including structural stabilities, interaction mechanisms, and DNA-binding abilities. Herein, we investigated the conformational dynamics of Δ133p53β and Δ160p53β with and without binding to p53-specific DNA by using molecular dynamics simulations. Read More

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December 2018

Orphan Receptor GPR88 as an Emerging Neurotherapeutic Target.

ACS Chem Neurosci 2018 Dec 12. Epub 2018 Dec 12.

While G protein-coupled receptors (GPCRs) are recognized as pivotal drug targets involved in multiple physiological and pathological processes, the majority of GPCRs including orphan GPCRs (oGPCRs) are unexploited. GPR88, a brain-specific oGPCR with particularly robust expression in the striatum, regulates diverse brain and behavioral functions including cognition, mood, movement control and reward-based learning, and is thus emerging as a novel drug target for CNS disorders including schizophrenia, Parkinson's disease, anxiety and addiction. Nevertheless, no effective GPR88 synthetic ligands have yet entered into clinical trials and GPR88 endogenous ligands remain unknown. Read More

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December 2018

Total Elbow Arthroplasty Versus Open Reduction and Internal Fixation for the Management of Distal Humerus Fractures in the Elderly.

Orthopedics 2018 Dec 11:1-6. Epub 2018 Dec 11.

Distal humerus fractures, which are challenging injuries seen in geriatric patients, are often repaired using open reduction and internal fixation or total elbow arthroplasty. This updated meta-analysis, which includes more recent open reduction and internal fixation techniques, examined outcomes following distal humerus fractures repaired using open reduction and internal fixation vs total elbow arthroplasty. Although distal humerus fractures treated with total elbow arthroplasty achieved statistically higher functional scores relative to those treated with open reduction and internal fixation, this difference was not clinically significant. Read More

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December 2018

[Recent advances in pediatric non-Hodgkin lymphoma. Report on a retrospective single-center cohort and review of the literature].

Magy Onkol 2018 Dec 15;62(4):204-213. Epub 2018 Oct 15.

Gyermekgyógyászati Intézet, Gyermekhematológiai-onkológiai nem önálló Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar, Debrecen, Hungary.

Classification, staging and treatment response criteria of pediatric NHL have been revised. Long-term survival reaches ~90% at the expense of severe acute toxicities. The outcome of refractory and relapsed cases is poor. Read More

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December 2018
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Developing an efficient protocol for monitoring eagle fatalities at wind energy facilities.

PLoS One 2018 12;13(12):e0208700. Epub 2018 Dec 12.

Avangrid Renewables, LLC, Portland, Oregon, United States of America.

Researchers typically conduct fatality monitoring to determine a wind energy facility's direct impacts on wildlife. In the United States, wind energy impacts on eagles have received increased attention in recent years because eagle incidental take permits became available. Permit holders are required to conduct fatality monitoring to evaluate compliance with permitted eagle take. Read More

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December 2018

Anti-smoking social norms are associated with increased cessation behaviours among lower and higher socioeconomic status smokers: A population-based cohort study.

PLoS One 2018 12;13(12):e0208950. Epub 2018 Dec 12.

Centre for Behavioural Research in Cancer, Cancer Council Victoria, Melbourne, Australia.

Background: Social denormalisation of smoking can provide an environment that helps smokers to quit. This study examined which of three measures of anti-smoking social norms have the greatest influence on quitting-related cognitions and behaviours, and if this influence differs according to socioeconomic status (SES).

Methods: The Victorian Tracking Survey measured social norms among 1,348 (n(weighted) = 1,373) Australian adult smokers (aged 18-59) between 2012 and 2014, who were followed-up one week later. Read More

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December 2018

New skeletal material sheds light on the palaeobiology of the Pleistocene marsupial carnivore, Thylacoleo carnifex.

PLoS One 2018 12;13(12):e0208020. Epub 2018 Dec 12.

Ecology and Evolution, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia.

The extinct marsupial 'lion' Thylacoleo carnifex was Australia's largest mammalian carnivore. Despite being the topic of more discussion than any other extinct Australian marsupial (excepting perhaps the Thylacine), basic aspects of its palaeobiology, including its locomotory repertoire, remain poorly understood. Recent discoveries allowed the first reconstruction of an entire skeleton including the first complete tail and hitherto-unrecognised clavicles. Read More

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December 2018

Exploring the influence of resiliency on physician trust in patients: An empirical study of Chinese incidents.

PLoS One 2018 12;13(12):e0207394. Epub 2018 Dec 12.

University of Science and Technology of China, Hefei, Anhui, China.

Background: The tension in doctor-patient relationships is becoming progressively greater due to the high expectations of patients and the physicians' work pressure. Recent studies have addressed factors which affect the tension of doctor-patient relationships, and our study continues this trend by looking at the influence of resiliency and physician trust in the patient (PTP), that is, how much the doctor trusts the patient.

Methods: Based on a survey of 329 physicians, a descriptive analysis of measured data was done using SPSS 19. Read More

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December 2018

Prey of killer whales (Orcinus orca) in Iceland.

PLoS One 2018 12;13(12):e0207287. Epub 2018 Dec 12.

Marine and Freshwater Research Institute, Skúlagata, Reykjavík, Iceland.

Killer whales have a cosmopolitan distribution and as a species are generalists, feeding on a variety of prey. However, local populations tend to specialise on specific prey types. In Icelandic waters, killer whales are generally associated with herring and, thus, have been presumed to be herring specialists. Read More

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December 2018

Esophageal IgG4: Clinical, Endoscopic, and Histologic Correlations in Eosinophilic Esophagitis.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Division of Pediatric Gastroenterology, Hepatology and Nutrition.

Objective: Recent studies show increased serum and esophageal IgG4 in patients with eosinophilic esophagitis (EoE), suggesting a possible IgG4-involved process. The role of IgG4 in pediatric EoE has not been extensively investigated. Our aim was to analyze IgG4 in esophageal tissue in children in parallel to that in adults with EoE. Read More

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December 2018
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ACSM PRE-PARTICIPATION HEALTH SCREENING GUIDELINES: A UK UNIVERSITY COHORT PERSPECTIVE.

Med Sci Sports Exerc 2018 Dec 11. Epub 2018 Dec 11.

Carnegie School of Sport, Leeds Beckett University, Leeds, United Kingdom.

Purpose: Pre-participation health screening is recommended to detect individuals susceptible to serious adverse cardiovascular complications during exercise. Although expert opinion and best available scientific evidence have informed recent modifications, there remains limited experimental data to support or refute current practice. We therefore aimed to quantify the impact of change to the ACSM pre-participation health screening guidelines on risk classification and referral for medical clearance in a large cohort of undergraduate university students. Read More

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December 2018

Combination of ST2 and B-type natriuretic peptide in diabetic patients with acute heart failure: relation with ventricular stiffness and outcome.

J Cardiovasc Med (Hagerstown) 2018 Dec 11. Epub 2018 Dec 11.

Cardiovascular Diseases Unit, Department of Internal Medicine, Le Scotte Hospital, University of Siena.

Background: Diabetes is a common disease in heart failure and its prevalence ranges from 10 to 30%. ST-2 is a novel biomarker of myocardial fibrosis and remodelling in heart failure and may be involved in the inflammatory process of diabetes mellitus. In this study, we sought: to evaluate levels of ST-2 and B-type natriuretic peptide (BNP) in groups with acute heart failure with and without diabetes; to analyse the prognostic impact of ST-2 over a 6-month follow-up period. Read More

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December 2018

In Vivo Analysis of Urinary Stones With Dual-Energy Computed Tomography.

J Comput Assist Tomogr 2018 Dec 12. Epub 2018 Dec 12.

Biochemistry, Faculty of Medicine, Selcuk University, Konya, Turkey.

Objective: Formation mechanisms and treatment of the urinary stones are different, depending on their chemical structure. Therefore, determining the stone type plays a key role in planning treatment and preventive measures. Computed tomography (CT), with the use of dual-energy technology in recent years, has made it possible to do in vivo analysis of urinary stones. Read More

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December 2018

Anticoagulation Management and Heparin Resistance During Cardiopulmonary Bypass: A Survey of Society of Cardiovascular Anesthesiologists Members.

Anesth Analg 2018 Dec 11. Epub 2018 Dec 11.

Department of Anesthesiology, Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.

We surveyed Society of Cardiovascular Anesthesiologists members regarding anticoagulation practices for cardiopulmonary bypass and attitudes on heparin resistance. Of 550 respondents (18.5% response rate), 74. Read More

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December 2018

Uptake and Tracer Kinetic of O-(2-(18)F-fluoroethyl)-L-Tyrosine in Meningioma.

Clin Nucl Med 2019 Jan;44(1):e22-e23

Department of Neurosurgery, CHRU Cavale Blanche.

F-fluoroethyltyrosine (FET) is a well-established PET tracer for the imaging of cerebral gliomas. Recent studies reported interest in meningiomas. A study published by Cornelius et al concludes that FET PET may provide additional information for noninvasive grading of meningiomas. Read More

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January 2019

Cannabis-related cognitive impairment: a prospective evaluation of possible influences on patients with cancer during chemotherapy treatment as a pilot study.

Anticancer Drugs 2019 Jan;30(1):91-97

Neuro-Cognitive Unit, Rambam Health Care Campus.

Objectives: In patients with cancer, the use of medical cannabis has increased significantly during the recent years. There is evidence that cannabis consumption may affect cognitive performance; however, this potential effect has not been investigated prospectively in patients with cancer to date. We aimed to evaluate the effect of cannabis consumption on cognitive abilities as well as on symptom relief in patients with cancer during chemotherapy treatment. Read More

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January 2019

Circulating tumor cells in metastatic breast cancer: clinical relevance and biological potential.

Curr Opin Obstet Gynecol 2018 Dec 11. Epub 2018 Dec 11.

Department of Gynecology and Obstetrics, Düsseldorf University Hospital, Düsseldorf, Germany.

Purpose Of Review: The possibility of tumor dissemination through the blood system has been known for years. Circulating tumor cells (CTCs) are detectable in the peripheral blood of patients with early as well as metastatic breast cancer. The prognostic relevance of this biomarker has already been described. Read More

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December 2018

Cell-based immunotherapy in gynecologic malignancies.

Curr Opin Obstet Gynecol 2018 Dec 11. Epub 2018 Dec 11.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford Women's Cancer Center, Stanford University School of Medicine, Stanford, California, USA.

Purpose Of Review: To provide an update on cell-based immunotherapies in solid tumors particularly in gynecological cancers.

Recent Findings: Improvements have been made in engineering T cells to overcome the immunosuppressive environment in ovarian cancer. Significant efforts are underway to create 'off the shelf' cell therapies which leverage natural killer (NK) cells and would not rely on engineering a patient's T cells. Read More

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December 2018

Poly-ADP-ribosyl-polymerase inhibitor resistance mechanisms and their therapeutic implications.

Authors:
Kelly E McCann

Curr Opin Obstet Gynecol 2018 Dec 11. Epub 2018 Dec 11.

David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.

Purpose Of Review: Poly-ADP-ribosyl-polymerase (PARP) inhibitors are an increasingly-utilized therapy in women with high-grade serous ovarian carcinoma, but tumor resistance to PARP inhibitor monotherapy is inevitable.

Recent Findings: PARP inhibitors have been most studied in patients with breast and ovarian cancers associated with deleterious germline BRCA1 or BRCA2 mutations, though their role has expanded to include use as maintenance therapy in women with platinum-sensitive high-grade serous ovarian cancer due to the high propensity of such cancers to have defects in DNA repair by homologous recombination. As mechanisms of PARP inhibitor resistance are elucidated, rationale combination strategies can be devised to extend therapeutic benefits and to abrogate resistance. Read More

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December 2018
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Neutrophils in lupus nephritis.

Curr Opin Rheumatol 2018 Dec 11. Epub 2018 Dec 11.

Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital & Harvard Medical School, Boston, USA.

Purpose Of Review: Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease characterized by IgG-autoantibodies to nuclear antigens that can deposit in the kidney and trigger lupus nephritis. Neutrophils accumulate in the kidneys of patients with proliferative LUPUS NEPHRITIS and neutrophil products and a subset of granulocytes, called low-density granulocytes (LDG) may contribute to lupus nephritis pathogenesis. Here, we will discuss recent studies implicating neutrophils in the pathogenesis of human SLE nephritis and then examine studies that provide mechanistic insights into how these cells are recruited to the glomerulus following immune complex deposition and how their products may promote lupus nephritis. Read More

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December 2018

Postactivated B cells in systemic lupus erythematosus: update on translational aspects and therapeutic considerations.

Curr Opin Rheumatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Medicine/Rheumatology and Clinical Immunology.

Purpose Of Review: This review summarizes recent insights and current understanding of the role of postactivated B cells in SLE and related pathogenic and potential therapeutic implications.

Recent Finding: B cells are considered key players in SLE and experience from various B-cell-targeted therapies underlines their clinical relevance. In the last years, new insights have been obtained on B-cell abnormality within the complex pathophysiology of SLE. Read More

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December 2018

Gene-function studies in SLE.

Curr Opin Rheumatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.

Purpose Of Review: The aim of this review is to discuss recent developments in our understanding of how systemic lupus erythematosus (SLE)-associated genes contribute to autoimmunity.

Recent Findings: Gene-function studies have revealed mechanisms through which SLE-associated alleles of IFIH1, TNFAIP3, IRF5, and PRDM1 likely contribute to the development of autoimmunity. Novel research has identified Mac-1 (encoded by ITGAM), CaMK4, and iRhom2 as plausible therapeutic targets in lupus nephritis. Read More

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December 2018
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Precise anesthesia in thoracoscopic operations.

Curr Opin Anaesthesiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Anesthesiology.

Purpose Of Review: The current review focuses on precise anesthesia for video-assisted thoracoscopic surgery (VATS) with the goal of enhanced recovery.

Recent Findings: VATS has become an established and widely used minimally invasive approach with broad implementation on a variety of thoracic operations. In the current environment of enhanced recovery protocols and cost containment, minimally invasive VATS operations suggest adoption of individualized tailored, precise anesthesia. Read More

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December 2018

Biomarkers of rejection in kidney transplantation.

Curr Opin Organ Transplant 2018 Dec 11. Epub 2018 Dec 11.

Division of Nephrology, Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan, USA.

Purpose Of Review: To provide an update of the literature on the use of new biomarkers of rejection in kidney transplant recipients.

Recent Findings: The kidney allograft biopsy is currently considered the gold standard for the diagnosis of rejection. However, the kidney biopsy is invasive and could be indeterminate. Read More

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December 2018

Complementary and integrative medicine in kidney transplantation.

Curr Opin Organ Transplant 2018 Dec 11. Epub 2018 Dec 11.

Division of Nephrology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, New York, USA.

Purpose Of Review: Complementary and integrative medicine (CIM) use is widely prevalent in kidney transplant recipients but studies of efficacy or potential harm are sparse. This review examines prevalence of use of CIM and discusses potential beneficial and harmful aspects of CIM in renal transplant recipients.

Recent Findings: The prevalence of CIM use in kidney transplant patients varies from 12 to 45%. Read More

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December 2018

Delayed graft function in kidney transplantation.

Curr Opin Organ Transplant 2018 Dec 11. Epub 2018 Dec 11.

Transplant Nephrology, Keck Hospital of USC, California, USA.

Purpose Of Review: Delayed graft function (DGF) has several long-term graft implications in the field of kidney transplantation and remains a challenge. The incidence of DGF is on the rise because of an increasing use of marginal kidneys in an era of organ shortage. Risk factors for DGF are numerous and stem from multiple sources in the transplant chain starting from the donor to its final allocation in the recipient. Read More

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December 2018

Mechanisms of disease: The endocrinology of obstructive sleep apnoea.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

A Tahrani, University of Birmingham, Institute of Metabolism and Systems Research, Birmingham, United Kingdom of Great Britain and Northern Ireland.

Obstructive sleep apnoea (OSA) is a common disorder that is associated with serious co-morbidities with a negative impact on quality of life, life expectancy and health costs. As OSA is related to obesity and is associated with sleep disruption, increased inflammation and oxidative stress, it is not surprising that OSA has an impact on the secretion of multiple hormones and is implicated in the development of many endocrine conditions. On the other hand, many endocrine conditions that can affect obesity and/or upper airways anatomy and stability have been implicated in the development or worsening of OSA. Read More

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December 2018

[Liver bud transplantation in rats].

Magy Seb 2018 Dec;71(4):163-169

Department of Organ Fabrication, Keio University School of Medicine 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Introduction: Research has made progress in organ fabrication using an extracellular matrix, cell sheets, or organoids. Human liver tissue has been constructed using a 3-dimensional (3D) bioprinter and showed evidence that an in vitro generated liver bud was reformed in a rodent liver model. This study describes the stages of development of rat fetal organs and liver structure and reviews recent progress in liver organoid transplantation. Read More

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December 2018

The Origin of Two-Dimensional Vertical Ferroelectricity in WTe Bilayer and Multilayer.

J Phys Chem Lett 2018 Dec 12. Epub 2018 Dec 12.

In a recent report (Nature 2018, 560, 336), room-temperature vertical ferroelectricity was experimentally shown in WTe2 bilayer, while its mechanism of ferroelectric switching without vertical ion displacements remains unclarified. In this work we reveal its origin by first-principles calculations that the polarization stems from uncompensated interlayer vertical charge transfer depending on in-plane translation, which can be switched upon interlayer sliding. The calculated results are consistent with experimental data, and similar switching mechanism can be applied to multilayer counterpart. Read More

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December 2018
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Intermolecular Acetoxyaminoalkylation of α-Diazo Amides with (Diacetoxyiodo)benzene and Amines.

Org Lett 2018 Dec 12. Epub 2018 Dec 12.

Institute of Organic Chemistry , University of Münster , Corrensstrasse 40 , 48149 Münster , Germany.

Multicomponent reactions of diazo compounds have attracted much attention in recent years. Such transformations are generally conducted by applying transition metal catalysis and involve the corresponding metal carbenes as key intermediates. In this letter, a metal-free three-component intermolecular acetoxyaminoalkylation of α-diazo amides with tertiary aryl amines and (diacetoxyiodo)benzene is presented. Read More

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December 2018

Single-Atom Alloys as a Reductionist Approach to the Rational Design of Heterogeneous Catalysts.

Acc Chem Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemistry , Tufts University , 62 Talbot Avenue , Medford , Massachusetts 02155 United States.

Heterogeneous catalysts are workhorses in the industrial production of most commodity and specialty chemicals, and have widespread energy and environmental applications, with the annual market value of the catalysts themselves reaching almost $20 billion in 2018. These catalysts are complex, comprising multicomponent materials and multiple structures, making their rational design challenging, if not impossible. Furthermore, typical active metals like Pt, Pd, and Rh are expensive and can be susceptible to poisoning by CO, coking, and they are not always 100% selective. Read More

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December 2018

Less is more: towards a genome-reduced Bacillus cell factory for 'difficult proteins'.

ACS Synth Biol 2018 Dec 12. Epub 2018 Dec 12.

The availability of complete genome sequences and the definition of essential gene sets were fundamental in the start of the genome engineering era. In a recent study, redundant and unnecessary genes were systematically deleted from the Gram-positive bacterium Bacillus subtilis, an industrial production host of high-value secreted proteins. This culminated in strain PG10, which lacks about 36% of the genome, thus representing the most minimal Bacillus chassis currently available. Read More

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December 2018

Up-to-date vaccine delivery systems: robust immunity elicited by multifarious nanomaterials upon administration through diverse routes.

Biomater Sci 2018 Dec 12. Epub 2018 Dec 12.

Department of Biomedical Sciences, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China. and City University of Hong Kong Shenzhen Research Institute, Shenzhen 518075, P. R. China.

In this review, we summarize the recent design strategies (2015-present) of nanomaterial-based vaccine delivery systems via multiple routes to induce robust protective immunity. The selected topics are focused on the novel design strategies of nanomaterial carriers for vaccine delivery. Inspired by recent advances, we also briefly introduce the emerging administration routes that may give rise to synergistic immune effects with advanced delivery systems. Read More

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December 2018

Proteomic analysis of the Heliothis virescens ascovirus 3i (HvAV-3i) virion.

J Gen Virol 2018 Dec 12. Epub 2018 Dec 12.

2​Institute of Virology, College of Plant Protection, Hunan Agricultural University, Changsha, Hunan 410128, PR China.

Ascoviruses are enveloped, circular, double-stranded DNA viruses that can effectively control the appetite of lepidopteran larvae, thereby reducing the consequent damage and economic losses to crops. In this study, the virion of a sequenced Heliothis virescens ascovirus 3i (HvAV-3i) strain was used to perform proteomic analysis using both in-gel and in-solution digestion. A total of 81 viral proteins, of which 67 were associated with the virions, were identified in the proteome of HvAV-3i virions. Read More

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December 2018

Cardiac Vagus and Exercise.

Physiology (Bethesda) 2019 Jan;34(1):71-80

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London , London , United Kingdom.

Lower resting heart rate and high autonomic vagal activity are strongly associated with superior exercise capacity, maintenance of which is essential for general well-being and healthy aging. Recent evidence obtained in experimental studies using the latest advances in molecular neuroscience, combined with human exercise physiology, physiological modeling, and genomic data suggest that the strength of cardiac vagal activity causally determines our ability to exercise. Read More

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January 2019

The Activity of Peptides of the Calcitonin Family in Bone.

Physiol Rev 2019 Jan;99(1):781-805

Department of Medicine, University of Auckland , Auckland , New Zealand.

Calcitonin was discovered over 50 yr ago as a new hormone that rapidly lowers circulating calcium levels. This effect is caused by the inhibition of calcium efflux from bone, as calcitonin is a potent inhibitor of bone resorption. Calcitonin has been in clinical use for conditions of accelerated bone turnover, including Paget's disease and osteoporosis; although in recent years, with the development of drugs that are more potent inhibitors of bone resorption, its use has declined. Read More

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January 2019

Parkinson's disease: a short story of 200 years.

Histol Histopathol 2018 Dec 12:18073. Epub 2018 Dec 12.

Clinical and Experimental Neuroscience Group (NiCE-IMIB), Department of Human Anatomy and Psychobiology, Institute for Aging Research, School of Medicine, University of Murcia, Murcia, Spain.

After Alzheimer's disease, Parkinson's disease (PD) is the second most prevalent and incidental neurodegenerative disorder, affecting more than 2% of the population older than 65 years old. Since it was first described 200 years ago by Dr James Parkinson, great steps have been made in the understanding of the pathology. However, the cause(s) that initiates and perpetuates the neurodegenerative process is (are) still not clear. Read More

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December 2018

Oxidative stress: therapeutic approaches for cervical cancer treatment.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e548s. Epub 2018 Dec 10.

Instituto do Cancer do Estado de Sao Paulo ICESP, Centro de Investigacao Translacional em Oncologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Objectives: Oxidative stress results from an imbalance between the generation and elimination of oxidant species. This condition may result in DNA, RNA and protein damage, leading to the accumulation of genetic alterations that can favor malignant transformation. Persistent infection with high-risk human papillomavirus types is associated with inflammatory responses and reactive oxygen species production. Read More

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December 2018
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Humanized practices of obstetric nurses: contributions in maternal welfare.

Rev Bras Enferm 2018 ;71(suppl 6):2620-2627

Universidade Federal de Mato Grosso. Cuiabá, Mato Grosso, Brazil.

Objective: To analyze the practice of obstetric nurses operating in a prenatal/delivery/postpartum unit of a university hospital in Mato Grosso and the maternal welfare resulted from the care provided in this scenario.

Method: Study with a quantitative approach, carried out in a prenatal/delivery/postpartum unit of a university hospital in Cuiabá, Mato Grosso. The data were collected through the Scale of Maternal Welfare in Delivery Situation 2, and the study included 104 recent mothers in the period from June to September 2016. Read More

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January 2018

Fluorogenic probes for super-resolution microscopy.

Org Biomol Chem 2018 Dec 12. Epub 2018 Dec 12.

Chemical Biology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok krt. 2, 1117 Budapest, Hungary.

Fluorogenic probes efficiently reduce non-specific background signals, which often results in highly improved signal-to-noise ratios. Although this implies improved resolution, fluorogenic probes in the context of super-resolution microscopy are somewhat overlooked. Several excellent reviews summarize recent developments in SRM techniques, labeling techniques or different aspects of small synthetic fluorophores, however there is no comprehensive review on fluorogenic probes suitable for super-resolution microscopy. Read More

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December 2018

Risk behaviors contributing to recent serious unintentional injuries among school-going adolescent boys in Kolkata: Application of zero-inflated count model.

Indian J Public Health 2018 Oct-Dec;62(4):265-270

Post-Graduate Trainee, Department of Community Medicine, Medical College and Hospital, Kolkata, West Bengal, India.

Background: Unintentional injuries have become a major noncommunicable disease burden, especially among the adolescents.

Objective: The current study was conducted to estimate the effect of different aspects of daily activities of adolescence for sustaining serious unintentional injuries in the past 1 year.

Methods: A cross-sectional survey with multistage sampling with validated pretested questionnaire was done among the school-going adolescent boys in Kolkata. Read More

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December 2018
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