1,022,364 results match your criteria Recent Patents on Engineering [Journal]


Sepsis-Associated Acute Kidney Injury: A Problem Deserving of New Solutions.

Nephron 2019 Apr 24:1-5. Epub 2019 Apr 24.

Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Sepsis-associated acute kidney injury (S-AKI) significantly worsens patient prognosis, and recent evidence suggests that the injury process begins early and may be sustained by therapies used to treat the sepsis (e.g., fluids resuscitation, antibiotics). Read More

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https://www.karger.com/Article/FullText/500167
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http://dx.doi.org/10.1159/000500167DOI Listing
April 2019
1 Read

Autophagy in Pulmonary Innate Immunity.

J Innate Immun 2019 Apr 24:1-10. Epub 2019 Apr 24.

Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

Autophagy is a major intracellular digestion system that delivers cytoplasmic components for degradation and recycling. In this capacity, autophagy plays an important role in maintaining cellular homeostasis by mediating the degradation of cellular macromolecules and dysfunctional organelles and regeneration of nutrients for cell growth. Autophagy is important in innate immunity, as it is responsible for the clearance of various pathogens. Read More

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http://dx.doi.org/10.1159/000497414DOI Listing
April 2019
2 Reads

Raman characterization of single-crystalline Ga0.96Mn0.04As:Zn nanowires realized by ion-implantation.

Nanotechnology 2019 Apr 24. Epub 2019 Apr 24.

Universidade Federal do Pará, Belem, 66075-110, BRAZIL.

Recent progress in the realization of magnetic GaAs nanowires doped with Mn has attracted a lot of attention due to their potential application in spintronics. In this work, we present a detailed Raman investigation of the structural properties of Zn doped GaAs (GaAs:Zn) and Mn-implanted GaAs:Zn (Ga0.96Mn0. Read More

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http://dx.doi.org/10.1088/1361-6528/ab1beaDOI Listing

Miniature electroparticle-cuff for wireless peripheral neuromodulation.

J Neural Eng 2019 Apr 24. Epub 2019 Apr 24.

Bioengineering, University of Texas at Dallas Erik Jonsson School of Engineering and Computer Science, 800 W. Campbell Rd., BSB 13.637, Richardson, Texas, 75080-3021, UNITED STATES.

Recent developments in peripheral nerve electrodes allow the efficient and selective neuromodulation of somatic and autonomic nerves, which has proven beneficial in specific bioelectronic medical applications. However, current most clinical devices are wired and powered by implantable batteries which suffer from several limitations. We recently developed a sub-millimeter inductively powered neural stimulator (electroparticle; EP), and in this study, we report the integration of the EP onto commercial cuff electrodes (EP-C) allowing the wireless activation of peripheral nerves. Read More

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http://dx.doi.org/10.1088/1741-2552/ab1c36DOI Listing

Testosterone inhibits aneurysm formation and vascular inflammation in male mice.

J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

M Akishita, Department of Geriatric Medicine, University of Tokyo, Tokyo, Japan.

Abdominal aortic aneurysm (AAA), one of the pathological phenotypes of vascular aging, is characterized by aortic dilation with impaired arterial wall integrity. Recent epidemiologic studies have shown that men with AAA have lower serum testosterone (T) compared to men without. However, the underlying mechanisms remain unclear. Read More

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http://dx.doi.org/10.1530/JOE-18-0646DOI Listing

3RAD-based systematics of the transitional Nearctic-Neotropical lubber grasshopper genus Taeniopoda (Orthoptera: Romaleidae).

Mol Phylogenet Evol 2019 Apr 21. Epub 2019 Apr 21.

Colección Nacional de Insectos, Instituto de Biología, Universidad Nacional Autónoma de México, 3er. Circuito Exterior s/n, Ciudad Universitaria, Copilco, Coyoacán, C.P. 04510, CdMx, México. Electronic address:

The genus Taeniopoda Stål (Romaleidae) is a group of Nearctic-Neotropical grasshoppers whose systematics has been largely neglected. A recent phylogenetic study based on morphology and mitochondrial and nuclear markers failed to resolve the species boundaries in this genus and showed a lack of reciprocal exclusivity between T. eques (Burmeister) and T. Read More

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http://dx.doi.org/10.1016/j.ympev.2019.04.019DOI Listing

Gene and Induced Pluripotent Stem Cell Therapy for Retinal Diseases.

Annu Rev Genomics Hum Genet 2019 Apr 24. Epub 2019 Apr 24.

Laboratory for Retinal Regeneration, Center for Biosystems Dynamics Research, RIKEN, Kobe, Hyogo 650-0047, Japan; email:

Given the importance of visual information to many daily activities, retinal degenerative diseases-which include both inherited conditions (such as retinitis pigmentosa) and acquired conditions (such as age-related macular degeneration)-can have a dramatic impact on human lives. The therapeutic options for these diseases remain limited. Since the discovery of the first causal gene for retinitis pigmentosa almost three decades ago, more than 250 genes have been identified, and gene therapies have been rapidly developed. Read More

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http://dx.doi.org/10.1146/annurev-genom-083118-015043DOI Listing

Enhancement of the Monolayer Tungsten-Disulfide Exciton Photoluminescence with a Two-Dimensional-Material/Air/Gallium-Phosphide In-Plane Microcavity.

ACS Nano 2019 Apr 24. Epub 2019 Apr 24.

Light-matter interaction with two-dimensional materials gained significant attention in recent years leading to the reporting of weak and strong coupling regimes, and effective nano-laser operation with various structures. Particularly, future applications involving monolayer materials in waveguide-coupled on-chip integrated circuitry and valleytronic nanophotonics require controlling, directing and optimizing photoluminescence. In this context, photoluminescence enhancement from monolayer transition-metal dichalcogenides on patterned semiconducting substrates becomes attractive. Read More

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http://dx.doi.org/10.1021/acsnano.8b09659DOI Listing

Endoscopic Robot-Assisted Simple Enucleation of Renal Tumours: Impact of Learning Curve and Tumour Complexity on Trifecta Outcomes.

Int J Med Robot 2019 Apr 24:e2000. Epub 2019 Apr 24.

Department of Urology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.

Background: In this article, we report the outcomes of endoscopic robot-assisted tumour enucleation (ERASE) using a trifecta system.

Methods: 182 patients were treated with ERASE by a single surgeon between October 2014 and February 2017 and were stratified by quartiles of distribution called ERASE eras 1-4, and PADUA-score risk group categories. The trifecta achievement rates in different ERASE eras and PADUA-score risk group categories were analysed. Read More

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http://dx.doi.org/10.1002/rcs.2000DOI Listing

Evaluation of AUDIT Consumption Items New Adaptation to Improve the Screening of College Students Binge Drinking.

Adicciones 2019 Mar 28;0(0):1145. Epub 2019 Mar 28.

Universidad Internacional de Valencia..

The strong presence of Binge Drinking (BD) amongst university students, as well as the consequences associated with the same and the changes taking place over recent years regarding its conceptualization make it necessary to examine the usefulness of screening instruments used to detect this drinking pattern. This study examines the usefulness of a briefer adaptation of the AUDIT proposed by Cortés, Giménez, Motos, and Sancerni (2017a).College students self-administered the AUDIT, the revised items 2 and 3 (A2r and A3r), and completed a weekly self-report of their alcohol intake. Read More

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http://dx.doi.org/10.20882/adicciones.1145DOI Listing

Statin use in cirrhotic patients with infectious diseases: A population-based study.

PLoS One 2019 24;14(4):e0215839. Epub 2019 Apr 24.

Department of Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.

Background: Recent studies have shown benefits of statins in patients with liver cirrhosis. However, it is still unknown if statins have a beneficial effect on the mortality of cirrhotic patients with bacterial infections.

Methods: The Taiwan National Health Insurance Database was searched, and 816 cirrhotic patients receiving statins with bacterial infections hospitalized between January 1, 2010 and December 31, 2013 were included in the study. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215839PLOS
April 2019
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Natural disaster preparedness in a multi-hazard environment: Characterizing the sociodemographic profile of those better (worse) prepared.

PLoS One 2019 24;14(4):e0214249. Epub 2019 Apr 24.

Department of Psychology, Pontificia Universidad Catolica de Chile, Santiago, Chile.

The growing multi-hazard environment to which millions of people in the world are exposed highlights the importance of making sure that populations are increasingly better prepared. The objective of this study was to report the levels of preparedness of a community exposed to two natural hazards and identify the primary sociodemographic characteristics of groups with different preparedness levels. A survey was conducted on 476 participants from two localities of the Atacama Region in the north of Chile during the spring of 2015. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214249PLOS

A taxonomic review and revisions of Microstomidae (Platyhelminthes: Macrostomorpha).

PLoS One 2019 24;14(4):e0212073. Epub 2019 Apr 24.

Department of Zoology, Naturhistoriska riksmuseet, Stockholm, Sweden.

Microstomidae (Platyhelminthes: Macrostomorpha) diversity has been almost entirely ignored within recent years, likely due to inconsistent and often old taxonomic literature and a general rarity of sexually mature collected specimens. Herein, we reconstruct the phylogenetic relationships of the group using both previously published and new 18S and CO1 gene sequences. We present some taxonomic revisions of Microstomidae and further describe 8 new species of Microstomum based on both molecular and morphological evidence. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212073PLOS

A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP.

PLoS Comput Biol 2019 Apr 24;15(4):e1006975. Epub 2019 Apr 24.

Institute of Biophysics, National Research Council, Palermo, Italy.

Across the mammalian nervous system, neurotrophins control synaptic plasticity, neuromodulation, and neuronal growth. The neurotrophin Brain Derived Neurotrophic Factor (BDNF) is known to promote structural and functional synaptic plasticity in the hippocampus, the cerebral cortex, and many other brain areas. In recent years, a wealth of data has been accumulated revealing the paramount importance of BDNF for neuronal function. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006975DOI Listing

Development of novel vaccines against human cytomegalovirus.

Hum Vaccin Immunother 2019 Apr 24:1-11. Epub 2019 Apr 24.

a Department of Pathology , Uniformed Services University of the Health Sciences , Bethesda , MD , USA.

Congenital human cytomegalovirus (HCMV) infection and HCMV infection of the immunosuppressed patients cause significant morbidity and mortality, and vaccine development against HCMV is a major public health priority. Efforts to develop HCMV vaccines have been ongoing for 50 y, though no HCMV vaccine has been licensed; encouraging and promising results have obtained from both preclinical and clinical trials. HCMV infection induces a wide range of humoral and T cell-mediated immune responses, and both branches of immunity are correlated with protection. Read More

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https://www.tandfonline.com/doi/full/10.1080/21645515.2019.1
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http://dx.doi.org/10.1080/21645515.2019.1593729DOI Listing
April 2019
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Current Paradigms and New Perspectives on Fetal Hypoxia: Implications for Fetal Brain Development in Late Gestation.

Am J Physiol Regul Integr Comp Physiol 2019 Apr 24. Epub 2019 Apr 24.

Pharmacodynamics, University of Florida, United States.

The availability of oxygen to the fetus is limited by the route taken by oxygen from atmosphere to fetal tissues, aided or diminished by pregnancy-associated changes in maternal physiology, and ultimately a function of atmospheric pressure and composition of the mother's inspired gas. Much of our understanding of the fetal physiological response to hypoxia comes from experiments designed to elucidate the cardiovascular and endocrine responses to transient hypoxia. Complementing this work is equally impactful research into the origins of intrauterine growth restriction, using animal models designed to restrict the transfer of oxygen from maternal to fetal circulation. Read More

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http://dx.doi.org/10.1152/ajpregu.00008.2019DOI Listing

Key Aroma Compounds in Oats and Oat Cereals.

J Agric Food Chem 2019 Apr 24. Epub 2019 Apr 24.

Department of Food Science and Technology , Oregon State University , 100 Wiegand Hall , Corvallis , Oregon 97331-6602 , United States.

Oats possess a unique flavor, comprising grain and nut-like sensory characteristics. The first comprehensive study of oat flavor by Heydanek and McGorrin [ Heydanek , M. G. Read More

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http://dx.doi.org/10.1021/acs.jafc.9b00994DOI Listing

From Molecular and Emulsified Ion Sensors to Membrane Electrodes: Molecular and Mechanistic Sensor Design.

Acc Chem Res 2019 Apr 24. Epub 2019 Apr 24.

University of Geneva , Department of Inorganic and Analytical Chemistry , Quai Ernest Ansermet 30 , Geneva 1211 , Switzerland.

Selective molecular ion probes are often insoluble in water and require a hydrophobic solvent environment for strong and selective binding, which runs counter to the desire of utilizing them in a homogeneous solution. This Account aims to guide the reader on how such molecules, often coined ionophores, can be harnessed to design exceptionally useful optical and electrochemical sensors. We start here with some historical context on the design of such ionophores and continue with the explanation of the response mechanism of optical and potentiometric sensors and the role of combined components to build a robust ion sensor. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00056DOI Listing
April 2019
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Obstruction is associated with perineural invasion in T3/T4 colon cancer.

Colorectal Dis 2019 Apr 24. Epub 2019 Apr 24.

Department of Surgical Oncology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Aim: Perineural invasion (PNI) is a risk factor for recurrence and metastasis, and consequently leads to decreased survival in patients with various malignancy. Recent studies showed that stent placement in obstructive colon cancer increases the frequency of PNI. We hypothesized that mechanical stress including obstruction itself may be associated with PNI. Read More

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http://dx.doi.org/10.1111/codi.14655DOI Listing

Current applications of fecal microbiota transplantation in intestinal disorders.

Kaohsiung J Med Sci 2019 Apr 24. Epub 2019 Apr 24.

Department of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Fecal microbiota transplantation (FMT) had been an ancient remedy for severe illness several centuries ago. Under modern medical analysis and evidence-based research, it has been proved as an alternative treatment for recurrent Clostridium difficile infection and recent randomized control study also showed that FMT could be an adjuvant treatment for inflammatory bowel disease. As we get a better understanding of the relationship between gut microbiota and systemic disease, FMT became a potential treatment to explore. Read More

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http://dx.doi.org/10.1002/kjm2.12069DOI Listing

First description of Theiler's disease associated virus (TDAV) infection and epidemiological investigation of equine pegivirus (EPgV) and equine hepacivirus (EqHV) coinfection in Brazil.

Transbound Emerg Dis 2019 Apr 24. Epub 2019 Apr 24.

Laboratório de Desenvolvimento Tecnológico em Virologia, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.

Recent advances in the study of equine pegivirus (EPgV), Theiler's disease associated virus (TDAV) and equine hepacivirus (EqHV) highlight their importance to veterinary and human health. To gain some insight into virus distribution, possible risk factors, presence of liver damage and genetic variability of these viruses in Brazil, we performed a cross-sectional study of EPgV and TDAV infections using a simultaneous detection assay, and assessed EqHV coinfection in different horse cohorts. Of the 500 serum samples screened, TDAV, EPgV and EPgV-EqHV were present in 1. Read More

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http://dx.doi.org/10.1111/tbed.13210DOI Listing

Nature of halogen-centered intermolecular interactions in crystal growth and design: Fluorine-centered interactions in dimers in crystalline hexafluoropropylene as a prototype.

J Comput Chem 2019 Apr 24. Epub 2019 Apr 24.

Department of Chemical System Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

The wide occurrence of halogen-centered noncovalent interactions in crystal growth and design prompted this study, which includes a mini review of recent advances in the field. Particular emphasis is placed on providing compelling theoretical evidence of the formation of these interactions between sites of positive electrostatic potential, as well as between sites of negative electrostatic potential, localized on the electrostatic surfaces of the bound fluorine atoms in a prototypical system, hexafluoropropylene (C F ), upon its interaction with another same molecule to form (C F ) dimers. The existence of σ- and π-hole interactions is shown for the stable dimers. Read More

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http://dx.doi.org/10.1002/jcc.25836DOI Listing

O- excess as a detector for co-extracted organics in vapor analyses of plant isotope signatures.

Rapid Commun Mass Spectrom 2019 Apr 24. Epub 2019 Apr 24.

Global Institute for Water Security, School of Environment and Sustainability, University of Saskatchewan, 11 Innovation Boulevard, Saskatoon, SK, S7N 3H5, Canada.

Rationale: The stable isotope compositions of hydrogen and oxygen in water (δ H and δ O values) have been widely used to investigate plant water sources, but traditional isotopic measurements of plant waters are expensive and labor intensive. Recent work with direct vapor equilibration (DVE) on laser spectroscopy has shown potential to sidestep limitations imposed by traditional methods. Here, we evaluate DVE analysis of plants with a focus on spectral contamination introduced by organic compounds. Read More

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http://dx.doi.org/10.1002/rcm.8470DOI Listing

The Wnt signaling pathway: a potential therapeutic target against cancer.

Ann N Y Acad Sci 2019 Apr 24. Epub 2019 Apr 24.

Division of Molecular Medicine, Bose Institute, Kolkata, India.

The role of the evolutionarily conserved Wnt signaling pathway is well documented in several cellular processes, such as cell proliferation, differentiation, cell motility, and maintenance of the stem cell niche. The very first indication that aberrant Wnt signaling can cause carcinogenesis came from a finding that the mutation of the adenomatous polyposis coli gene (APC) predisposes a person to colorectal carcinoma. Later, with progressing research it became clear that abnormal activation or mutation of the genes related to this pathway could drive tumorigenesis. Read More

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http://dx.doi.org/10.1111/nyas.14027DOI Listing

The Austrian UVA-Network.

Photochem Photobiol 2019 Apr 24. Epub 2019 Apr 24.

Medical University Innsbruck, Div. of Biomedical Physics, Austria.

The ultraviolet-A (UVA) part of the solar spectrum at the Earth's surface is an essential environmental factor but continuous long-time monitoring of UVA radiation is rarely done. In Austria, three existing stations of the UV monitoring network have been upgraded with UVA broadband instruments. At each station, one instrument measures global UVA irradiance and - in parallel - a second instrument measures diffuse irradiance. Read More

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http://dx.doi.org/10.1111/php.13111DOI Listing

Association of Rivaroxaban With Thromboembolic Events in Patients With Heart Failure, Coronary Disease, and Sinus Rhythm: A Post Hoc Analysis of the COMMANDER HF Trial.

JAMA Cardiol 2019 Apr 24. Epub 2019 Apr 24.

Universite de Lorraine, INSERM Unite 1116, Vandoeuvre les Nancy, France.

Importance: Whether anticoagulation benefits patients with heart failure (HF) in sinus rhythm is uncertain. The COMMANDER HF randomized clinical trial evaluated the effects of adding low-dose rivaroxaban to antiplatelet therapy in patients with recent worsening of chronic HF with reduced ejection fraction, coronary artery disease (CAD), and sinus rhythm. Although the primary end point of all-cause mortality, myocardial infarction, or stroke did not differ between rivaroxaban and placebo, there were numerical advantages favoring rivaroxaban for myocardial infarction and stroke. Read More

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http://dx.doi.org/10.1001/jamacardio.2019.1049DOI Listing

Trends in Treatment and Spending for Patients Receiving Outpatient Treatment of Depression in the United States, 1998-2015.

JAMA Psychiatry 2019 Apr 24. Epub 2019 Apr 24.

Department of Health Policy and Management, Emory University, Atlanta, Georgia.

Context: After marked increases from 1987 to 1997, trends in depression treatment in the United States increased modestly from 1998 to 2007. However, multiple policy changes that expanded insurance coverage for mental health conditions may have shifted these trends again since 2007.

Objective: To examine national trends in outpatient treatment of depression from 1998 to 2015, with particular focus on 2007 to 2015. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2019.0633DOI Listing

Chemical composition of DNA-encoded libraries, past present and future.

Org Biomol Chem 2019 Apr 24. Epub 2019 Apr 24.

Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.

DNA-encoded libraries represent an exciting and powerful modality for high-throughput screening. In this article, we highlight recent important advances in this field and also suggest some important directions that would make the technology even more powerful. Read More

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http://dx.doi.org/10.1039/c9ob00581aDOI Listing

Seasonality Patterns of Internet Searches on Mental Health: Exploratory Infodemiology Study.

JMIR Ment Health 2019 Apr 24;6(4):e12974. Epub 2019 Apr 24.

Anxiety Treatment and Research Clinic, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.

Background: The study of seasonal patterns of public interest in psychiatric disorders has important theoretical and practical implications for service planning and delivery. The recent explosion of internet searches suggests that mining search databases yields unique information on public interest in mental health disorders, which is a significantly more affordable approach than population health studies.

Objective: This study aimed to investigate seasonal patterns of internet mental health queries in Ontario, Canada. Read More

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http://dx.doi.org/10.2196/12974DOI Listing

Computational neural network in melanocytic lesions diagnosis: artificial intelligence to improve diagnosis in dermatology?

Eur J Dermatol 2019 Apr;29(S1):4-7

Facolta di Medicina et Chirugia, UNIMORE Iniversita Degli Studi di Modena e Reggio Emilia, Modena, Italy.

Diagnosis in dermatology is largely based on contextual factors going far beyond the visual and dermoscopic inspection of a lesion. Diagnostic tools such as the different types of dermoscopy, confocal microscopy and optical coherence tomography (OCT) are available and all of these have shown their importance in improving the dermatologist's ability, especially in the diagnosis of skin cancer. Their use, however, remains limited and time consuming, and optimizing their practice appears to be difficult, requiring extensive pre-processing, lesion segmentation and extraction of domain-specific visual features before classification. Read More

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http://dx.doi.org/10.1684/ejd.2019.3538DOI Listing

How Do Pharmaceutical Companies Model Survival of Cancer Patients? A Review of NICE Single Technology Appraisals in 2017.

Int J Technol Assess Health Care 2019 Jan;35(2):160-167

Warwick Evidence,Warwick Medical School,University of Warwick.

Objectives: Before an intervention is publicly funded within the United Kingdom, the cost-effectiveness is assessed by the National Institute of Health and Care Excellence (NICE). The efficacy of an intervention across the patients' lifetime is often influential of the cost-effectiveness analyses, but is associated with large uncertainties. We reviewed committee documents containing company submissions and evidence review group (ERG) reports to establish the methods used when extrapolating survival data, whether these adhered to NICE Technical Support Document (TSD) 14, and how uncertainty was addressed. Read More

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http://dx.doi.org/10.1017/S0266462319000175DOI Listing
January 2019

Comparing the cup deformation following implantation of a novel ceramic-on-ceramic hip resurfacing bearing to a metal standard in a cadaveric model.

Proc Inst Mech Eng H 2019 Apr 24:954411919845721. Epub 2019 Apr 24.

1 Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Hip resurfacing is an attractive alternative to total hip replacement preserving bone and reducing dislocation risk. Recent metal-on-metal designs have caused failure due to metal wear debris. Ceramic implants may mitigate this risk. Read More

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http://dx.doi.org/10.1177/0954411919845721DOI Listing

Mining novel biosynthetic machineries of secondary metabolites from actinobacteria.

Authors:
Yohei Katsuyama

Biosci Biotechnol Biochem 2019 Apr 24:1-10. Epub 2019 Apr 24.

a Department of Biotechnology, Graduate School of Agriculture and Life Sciences , The University of Tokyo , Bunkyo-ku , Japan.

Secondary metabolites produced by actinobacteria have diverse structures and important biological activities, making them a useful source of drug development. Diversity of the secondary metabolites indicates that the actinobacteria exploit various chemical reactions to construct a structural diversity. Thus, studying the biosynthetic machinery of these metabolites should result in discovery of various enzymes catalyzing interesting and useful reactions. Read More

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http://dx.doi.org/10.1080/09168451.2019.1606700DOI Listing

Lizard Tail Extracts Exert Protective Effect Against Oxidative Stress-Induced Cellular Senescence in Human Fibroblasts.

J Med Food 2019 Apr 24. Epub 2019 Apr 24.

1 Department of Biological Science, Dong-A University, Busan, Korea.

Lizards are the evolutionary closest animals to humans among the self-renewable species. Recent reports show that lizard tail extracts (LTE) inhibit the proliferation and angiogenesis of cancer cells but do not show any toxicity against human fibroblast cells. Nevertheless, few scientific studies investigated the effects of LTE on the treatment of skin diseases, especially oxidative stress aging. Read More

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http://dx.doi.org/10.1089/jmf.2018.4369DOI Listing

Fluoroscopic Self-Expandable metallic stent placement for treating postoperative nonanastomotic strictures in the proximal small bowel: A 15-Year single institution experience.

Br J Radiol 2019 Apr 24:20180957. Epub 2019 Apr 24.

3 Department of Radiologic Technology, Cheju Halla University , Jeju , Republic of Korea.

Objectives: To evaluate the efficacy and safety of fluoroscopic self-expandable metallic stent (SEMS) placement for treating postoperative nonanastomotic strictures in the proximal small bowel.

Methods: Data from eight consecutive patients (mean age, 63.8 ± 6. Read More

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http://dx.doi.org/10.1259/bjr.20180957DOI Listing

Accreditation Council for Graduate Medical Education (ACGME) Self-Study for Pathology: One Institution's Experience and Lessons Learned.

Arch Pathol Lab Med 2019 Apr 24. Epub 2019 Apr 24.

From the Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Context.—: The Accreditation Council for Graduate Medical Education (ACGME) established a new system for accreditation of residency and fellowship programs in 2013. One key aspect of the Next Accreditation System is the 10-year self-study, which requires programs to conduct a comprehensive self-evaluation, including development of program aims and analysis of strengths, weaknesses, and environmental context, in order to plan improvements and take the program to the next level. Read More

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http://dx.doi.org/10.5858/arpa.2018-0467-RADOI Listing

Branched-Selective Alkene Hydroboration Catalyzed by Earth-Abundant Metals.

J Org Chem 2019 Apr 24. Epub 2019 Apr 24.

Catalytic hydroboration of alkenes is a well-established method to access borane-functionalized hydrocarbons. While linear-selective hydroboration was predominantly reported, catalysts enabling opposite selectivity (branched-selective) are attracting considerable interests, especially when Earth-abundant metals are utilized. This Synopsis summarizes recent progress in Earth-abundant-metal-catalyzed, branched-selective hydroboration of alkenes, while overviewing the historical contributions to this reaction using precious metals. Read More

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http://dx.doi.org/10.1021/acs.joc.9b00550DOI Listing

A Direct-Bandgap 2D Silver-Bismuth Iodide Double Perovskite: The Structure-Directing Influence of an Oligothiophene Spacer Cation.

J Am Chem Soc 2019 Apr 23. Epub 2019 Apr 23.

Three-dimensional (3D) hybrid organic-inorganic lead halide perovskites (HOIPs) feature remarkable optoelectronic properties for solar energy conversion but suffer from long-standing issues of environmental stability and lead-toxicity. Associated two-dimensional (2D) analogs are garnering increasing interest due to superior chemical stability, structural diversity and broader property tunability. Towards lead-free 2D HOIPs, double perovskites (DPs) with mixed valent dual metals are attractive but remain unexplored beyond a recent 2D Ag-Bi bromide DP with n-butylammonium spacer cations. Read More

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http://dx.doi.org/10.1021/jacs.9b02909DOI Listing

Free energies and entropies of binding sites identified by MixMD cosolvent simulations.

J Chem Inf Model 2019 Apr 24. Epub 2019 Apr 24.

In our recent efforts to map protein surfaces using mixed-solvent molecular dynamics (MixMD),1 we were able to successfully capture active sites and allosteric sites within the top-four most occupied hotspots. In this study, we describe our approach for estimating the thermodynamic profile of the binding sites identified by MixMD. First, we establish a framework for calculating free energies from MixMD simulations, and we compare our approach to alternative methods. Read More

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http://pubs.acs.org/doi/10.1021/acs.jcim.8b00925
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http://dx.doi.org/10.1021/acs.jcim.8b00925DOI Listing
April 2019
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Unexpected Precatalyst σ-Ligand Effects in Phenoxyimine Zr-Catalyzed Ethylene/1-Octene Copolymerizations.

J Am Chem Soc 2019 Apr 24. Epub 2019 Apr 24.

Recent decades have witnessed intense research efforts aimed at developing new homogeneous olefin polymerization catalysts, with a primary focus on metal-Cl or metal -hydrocarbyl precursors. Curiously, metal-NR2 precursors have received far less attention. In this contribution, the Zr-amido complex FI2ZrX2 (FI = 2,4-di-tert-butyl-6-((isobutylimino)methyl)phenolate, X = NMe2) is found to exhibit high ethylene polymerization activity and relatively high 1-octene co-enchainment selectivity (up to 7. Read More

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http://dx.doi.org/10.1021/jacs.9b01445DOI Listing

Evolving evidences of calreticulin as a pharmacological target in neurological disorders.

ACS Chem Neurosci 2019 Apr 24. Epub 2019 Apr 24.

Calreticulin (CALR), a lectin-like ER chaperone, was initially known only for its house-keeping function, but today it is recognized for many versatile roles in different compartments of a cell. Apart from canonical roles in protein folding and calcium homeostasis it performs a variety of non-canonical roles, majorly in CNS development. In past, studies have linked Calreticulin with various other biological components which are detrimental in deciding the fate of neurons. Read More

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http://pubs.acs.org/doi/10.1021/acschemneuro.9b00158
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http://dx.doi.org/10.1021/acschemneuro.9b00158DOI Listing
April 2019
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Clinical importance of the updated Oxford classification in allograft IgA nephropathy.

Am J Transplant 2019 Apr 24. Epub 2019 Apr 24.

Kidney Research Institute, Seoul National University College of Medicine, Seoul, Korea.

With the recent update to the Oxford classification for allograft IgA nephropathy (IgAN), additional investigations on the clinical significance of the updated components are warranted. We performed a retrospective cohort study at two tertiary hospitals. Kidney transplant recipients diagnosed with allograft IgAN were included in the study after additional review by specialized pathologists. Read More

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http://dx.doi.org/10.1111/ajt.15400DOI Listing

Knee joint function, walking ability, and quality of life within 6 weeks after total knee arthroplasty: a prospective cohort study.

J Clin Nurs 2019 Apr 24. Epub 2019 Apr 24.

College of Nursing, Taipei Medical University, Taiwan.

Aims And Objectives: The aims of this study were to track changes in patients' knee function, walking ability, and quality of life (QOL) before and after knee arthroplasty surgery and explore factors that influenced these parameters.

Background: The number of days as an inpatient for those who undergo joint replacement operations has been greatly reduced in recent years. However, it remains unclear whether shortening the inpatient time has affected patients' recovery or their QOL. Read More

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http://dx.doi.org/10.1111/jocn.14888DOI Listing

Response to Wi, D. (2018) Letter: Sleep disturbance in people with diabetes: A concept analysis.

J Clin Nurs 2019 Apr 24. Epub 2019 Apr 24.

College of Nursing, University of Illinois at Chicago, Chicago, IL, U.S.

We would like to thank Dahee Wi for the interest and comments on our recent publication (Zhu et al., 2018). We welcome this dynamic dialogue on defining the concept of sleep disturbance in people with diabetes. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jocn.14886
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http://dx.doi.org/10.1111/jocn.14886DOI Listing
April 2019
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The impact of concurrent HIV and type II diabetes on immune maturation, immune regulation and immune activation.

APMIS 2019 Apr 24. Epub 2019 Apr 24.

Viro-Immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, University Hospital of Copenhagen, 2100 Kbh Ø, Copenhagen, Denmark.

Tingstedt JL, Hove-Skovsgaard M, Gaardbo J, Ullum H, Nielsen SD, Gelpi M. The impact of concurrent HIV and type II diabetes on immune maturation, immune regulation and immune activation. Chronic immune activation and inflammation are constant findings in people living with HIV (PLWH) and contribute to the risk of non-AIDS-related morbidities, including cardiovascular diseases (CVD). Read More

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http://dx.doi.org/10.1111/apm.12956DOI Listing

lncRNA FOXD3-AS1 is associated with clinical progression and regulates cell migration and invasion in breast cancer.

Cell Biochem Funct 2019 Apr 24. Epub 2019 Apr 24.

Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, PR China.

For women, breast cancer is the most commonly diagnosed cancer and the leading cause of women deaths due to cancer. In recent years, increasing long noncoding RNA (lncRNA) has been discovered to be related to tumorigenesis, progression, and prognosis. FOXD3-AS1 is a lncRNA and has been identified as a cancer-promoting gene in glioma. Read More

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http://dx.doi.org/10.1002/cbf.3393DOI Listing

[Is it possible to extract intracranial pressure information based on the EEG activity?]

Rev Neurol 2019 May;68(9):375-383

Hospital Universitario de la Princesa, Madrid, Espana.

Introduction: The capability of the electroencephalography (EEG) of recording the bioelectrical activity of the brain has made of it a fundamental tool for the evaluation of the patient's neurological condition. In recent years, moreover, it has also begun to be used in obtaining information for other kind of variables, as the ones related with the cerebral hemodynamics.

Aim: To study the potential relationship between the EEG activity and the intracranial pressure (ICP) in patients suffering from traumatic brain injury and subarachnoid hemorrhage, during their stay at the intensive care unit. Read More

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http://dx.doi.org/10.33588/rn.6809.2018179DOI Listing

Afzelin suppresses proinflammatory responses in particulate matter-exposed human keratinocytes.

Int J Mol Med 2019 Jun 11;43(6):2516-2522. Epub 2019 Apr 11.

Department of Dermatology, Chung‑Ang University Hospital, Seoul 06973, Republic of Korea.

Particulate matter (PM), a widespread airborne contaminant, is a complex mixture of solid and liquid particles suspended in the air. Recent studies have demonstrated that PM induces oxidative stress and inflammatory reactions, and may cause certain skin diseases. Afzelin is a flavonoid isolated from Thesium chinense Turcz, which has anti‑inflammatory, anticancer and antibacterial properties. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4162DOI Listing

A methodological proposal for the analysis of Cladocera (Crustacea, Branchiopoda) subfossils from sediments of temporary aquatic ecosystems.

Braz J Biol 2019 Apr 18. Epub 2019 Apr 18.

Laboratório de Ecologia Aquática, Conservação e Evolução, Universidade Federal de Ouro Preto - UFOP, Campus Morro do Cruzeiro, s/n, Ouro Preto, MG, Brasil.

The main objective of the present study was to promote some adaptations to the standard methodology used in the analysis of Cladocera subfossils. The samples used in this study were collected at Lagoa dos Coutos, a temporary lake located on an outcrop with iron-rich duricrust in the Serra do Gandarela (Minas Gerais, Brazil). The sediment from this pond, typical of temporary ecosystems in the region, is characterized by rigid concretions that are difficult to dissolve in aqueous media, making it difficult to visualize and analyze subfossils taxa. Read More

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http://dx.doi.org/10.1590/1519-6984.192126DOI Listing
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