15 results match your criteria Recent Patents on Endocrine Metabolic & Immune Drug Discovery [Journal]

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Complications of Diabetes: An Insight into Genetic Polymorphism and Role of Insulin.

Recent Pat Inflamm Allergy Drug Discov 2018 ;12(1):78-86

Department of Law, Govt. College University, Faisalabad, Pakistan.

Background: Diabetes Mellitus (DM) is an advanced and chronic endocrine disorder characterized by an insufficiency of insulin secretion from pancreatic β-cells and liver, adipose tissues, and skeletal muscles.

Objective: The main objective of this study is to understand the mechanism and genes which are responsible for the prevalence of diabetes. The study also covers various types of diabetic complications with special reference to insulin role and defects. Read More

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http://dx.doi.org/10.2174/1872213X12666180717165331DOI Listing
December 2018
19 Reads

Diabetic Complications and Insight into Antidiabetic Potentialities of Ethno- Medicinal Plants: A Review.

Recent Pat Inflamm Allergy Drug Discov 2018 ;12(1):7-23

Tecnologico de Monterrey, School of Engineering and Sciences, Campus Monterrey, Ave. Eugenio Garza Sada 2501, Monterrey, N.L. CP 64849, Mexico.

Background: The naturally inspired treatment options for several disease conditions and human-health related disorders such as diabetes mellitus have gained considerable research interest. In this context, naturally occurring plants and herbs with medicinal functionalities have gained special place than ever before in the current medicinal world.

Objective: The objective of this review is to extend the current knowledge in the clinical field related to the diabetic complications. Read More

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http://dx.doi.org/10.2174/1872213X12666180221161410DOI Listing
December 2018
6 Reads

Medicinal and Beneficial Health Applications of Tinospora cordifolia (Guduchi): A Miraculous Herb Countering Various Diseases/Disorders and its Immunomodulatory Effects.

Recent Pat Endocr Metab Immune Drug Discov 2017 ;10(2):96-111

Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj. Iran.

Background: Plants have been known as an integral part of traditional medicine because of their phytoconstituents with their miraculous substances. Tinospora cordifolia (Guduchi/ Giloy) is one such plant having pharmacological functions and medicinal values due to its several constituents such as terpenes, glycosides, alkaloids, steroids and flavonoids. Thus, it has been rightly mentioned in old texts as "Amrita". Read More

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http://dx.doi.org/10.2174/1872214811666170301105101DOI Listing
November 2017
18 Reads

Role of Iodine in Metabolism.

Recent Pat Endocr Metab Immune Drug Discov 2017 ;10(2):123-126

Department of Endocrinology, Jagiellonian University Collegium Medicum, 31-501 Krakow, 17 Kopernika St.. Poland.

The natural resources of iodine are seawater, seaweeds and saltpeter-nitrate deposits in Chile. Over 1/3 of the global population is exposed to iodine deficiency, especially in the mountains. Iodine is a component of the thyroid hormones and a strong antioxidant with electric potential of -0. Read More

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http://dx.doi.org/10.2174/1872214811666170119110618DOI Listing
November 2017
4 Reads

The Regulatory Roles of Mitogen-Activated Protein Kinase (MAPK) Pathways in Health and Diabetes: Lessons Learned from the Pancreatic β-Cell.

Recent Pat Endocr Metab Immune Drug Discov 2017 ;10(2):76-84

B-4237 Research Service, John D. Dingell VA Medical Center, 4646 John R, Detroit, MI 48201. United States.

Background: Glucose-stimulated insulin secretion (GSIS) from the pancreatic β-cell involves several intracellular metabolic events which lead to the translocation of insulin granules towards the membrane for fusion and release. It is well established that loss of β-cell function and decreased GSIS underlie the pathogenesis of diabetes. Evidence from several laboratories, including our own, demonstrated requisite roles of Rac1 and phagocyte-like NADPH oxidase (Nox2)-derived reactive oxygen species (ROS) in optimal function of the pancreatic β-cell, including GSIS. Read More

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http://dx.doi.org/10.2174/1872214810666161020154905DOI Listing
November 2017
3 Reads

A patent review of glucokinase activators and disruptors of the glucokinase--glucokinase regulatory protein interaction: 2011-2014.

Expert Opin Ther Pat 2014 Aug 12;24(8):875-91. Epub 2014 May 12.

Cardiovascular, Metabolic & Endocrine Diseases Chemistry, Pfizer Worldwide Research & Development , 610 Main St, Cambridge, MA 02139 , USA +1 617 551 3267 ; +1 617 551 3082 ;

Introduction: Glucokinase (GK) is a key regulator of glucose homeostasis, and development of small molecule activators of this enzyme represents a promising new approach for the treatment of type 2 diabetes mellitus.

Areas Covered: This manuscript reviews small molecule patent disclosures between late 2011 and February 2014 for both GK activators (GKAs) and GK-glucokinase regulatory protein (GK-GKRP) disruptors. The review is organized by company and structural class. Read More

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http://dx.doi.org/10.1517/13543776.2014.918957DOI Listing
August 2014
3 Reads

Metabolic syndrome and asthma.

Recent Pat Endocr Metab Immune Drug Discov 2014 Jan;8(1):60-6

Instituto de Inmunologia, Facultad de Medicina, Universidad Central de Venezuela, Apartado 50109, Caracas 1050-A, Venezuela.

Metabolic syndrome (MetS) is a syndrome that involves at least three disorders dyslipidemia, insulin resistance, obesity and/or hypertension. MetS has been associated with several chronic diseases in the adulthood; however, in the recent years, the syndrome was redefined in children. Girls with early menarche and asthma, and children with MetS and asthma that reach adulthood appear to have higher risk to develop severe or difficult to control asthma and a higher probability to suffer cardiovascular diseases. Read More

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January 2014
2 Reads

The two faces of protein palmitoylation in islet β-cell function: potential implications in the pathophysiology of islet metabolic dysregulation and diabetes.

Recent Pat Endocr Metab Immune Drug Discov 2013 Sep;7(3):203-12

Beta-cell Biochemistry Laboratory, B-4237 Research Service, John D. Dingell VA Medical Center, 4646 John R, Detroit, MI 48201,USA.

Several cellular proteins undergo post-translational lipidation, including prenylation, palmitoylation and myristoylation, which are felt to promote intracellular targeting, membrane association and interaction with effector partner proteins. Recent findings implicate definitive roles of isoprenylation in islet β-cell function including glucose-stimulated insulin secretion [GSIS]. Published evidence also suggests novel regulatory roles for protein palmitoylation not only in GSIS but also in the metabolic dysfunction induced by proinflammatory cytokines and lipotoxic conditions. Read More

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September 2013
8 Reads

Targets of anti-glucocorticoid therapy for stress-related diseases.

Recent Pat CNS Drug Discov 2013 Apr;8(1):79-87

Geriatric Unit, Faculty of Medicine and Psychology, Sapienza University of Rome, S. Andrea Hospital, Rome, Italy.

The stress response during chronic conditions increases vulnerability to diseases through the activation of adaptive systems, in particular, the hypothalamus-pituitary-adrenal (HPA) axis. Dysregulation in HPA activity (central and peripheral) has been reported in chronic diseases, like metabolic syndrome, type-2 diabetes mellitus, atherosclerosis-related disease, essential hypertension, dementia, depression, particularly during comorbid conditions. Different targets of anti-glucocorticoid treatment have been proposed, acting at supra-hypothalamic, HPA axis, glucocorticoid receptor and post-receptor levels. Read More

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April 2013
9 Reads

Glucokinase activators.

Pharm Pat Anal 2012 Jul;1(3):301-11

Cardiovascular, Metabolic & Endocrine Disease Research, Pfizer Worldwide Research & Development, Cambridge, MA 02139, USA.

In this review we highlight recently disclosed progress in the field of small-molecule activators of the human glucokinase enzyme. Several of the reported chemotypes possess structural features that diverge from known leads; some of these modifications appear to be specifically designed to modulate tissue selectivity or discrete parameters of enzyme function (e.g. Read More

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http://dx.doi.org/10.4155/ppa.12.26DOI Listing
July 2012
3 Reads

Light deficiency confers breast cancer risk by endocrine disorders.

Authors:
Zsuzsanna Suba

Recent Pat Anticancer Drug Discov 2012 Sep;7(3):337-44

National Institute of Oncology, Surgical and Molecular Tumor Pathology Centre, 1122 Ráth György u. 7-9, Budapest, Hungary.

North-America and northern European countries exhibit the highest incidence rate of breast cancer, whereas women in southern regions are relatively protected. Immigrants from low cancer incidence regions to high-incidence areas might exhibit similarly higher or excessive cancer risk as compared with the inhabitants of their adoptive country. Additional cancer risk may be conferred by incongruence between their biological characteristics and foreign environment. Read More

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September 2012
1 Read

Anti diabetic effect of cherries in alloxan induced diabetic rats.

Recent Pat Endocr Metab Immune Drug Discov 2012 Jan;6(1):67-72

Department of Biology, Urmia University, Urmia, Iran.

Diabetes mellitus (DM) is a metabolic disorder in the endocrine system resulting from a defect in insulin secretion, insulin action or both of them. Adverse side effects of chemical drugs for treatment of diabetes persuaded the using of medical plants. Cherry as a traditionally used plant for treatment of diabetes, is packed with powerful plant pigments called anthocyanins. Read More

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January 2012
4 Reads

Leptin as clinical target.

Recent Pat Inflamm Allergy Drug Discov 2009 Nov;3(3):160-6

Department of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA.

PLeptin is an adipocyte-derived hormone with pleiotropic effects on energy homeostasis, endocrine and reproductive functions, and immune responses. The multiple actions of leptin have led to the design and development of several leptin-based approaches to modulate the metabolic and endocrine status, to reduce inflammation, and to improve immune responses. Here, we review the current patents on leptin in different clinic applications. Read More

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November 2009
1 Read

Microbial biotransformation: recent developments on steroid drugs.

Recent Pat Biotechnol 2009 ;3(2):141-53

Integrated Biotechnology Laboratory, School of Life Science, Anhui University, Hefei, P.R. China.

About 300 of steroid drugs have been identified since the research and development to steroid drugs was triggered in 1950's. Although much progress in microbial biotransformation on steroid drugs is well-achieved, many efforts are ongoing in order to improve the efficiency of steroidal drug production as well as to degrade their derivatives. In this work an overview of recent and important findings related to patents and various microbial biotransformations of steroidal compounds including dehydrogenation/reduction, hydroxylation, esterification, methylation, halogenation and methoxylation is presented. Read More

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August 2009
69 Reads

Rimonabant for the treatment of obesity.

Recent Pat Cardiovasc Drug Discov 2008 Nov;3(3):187-93

Department of Medicine, University of Birmingham, Edgbaston, Birmingham, UK.

Obesity is a growing public health problem that is already reaching epidemic proportions and is increasingly encompassing young children and adolescents. Despite the increasing prevalence and the health risks associated with obesity, the pharmacotherapeutic options for treating obesity are limited. The endogenous cannabinoid or endocan-nabinoid system (ECS) was discovered in the early 1990s in relation to work on the action of components of marijuana. Read More

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http://www.nets.nihr.ac.uk/__data/assets/pdf_file/0004/82507
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November 2008
3 Reads
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