997,338 results match your criteria Recent Patents on Electrical Engineering [Journal]


Educational needs for new graduate nurses in Korea.

Nurse Educ Pract 2018 Dec 5;34:167-172. Epub 2018 Dec 5.

College of Nursing, Ewha Womans University, Hellen hall, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, South Korea. Electronic address:

New nursing graduates often experience difficulty adjusting to clinical work environments, despite completing well-structured education programs. This study explored the educational needs of recent nursing graduates from the perspectives of new nurses and their clinical educators in Korea. Four focus-group interviews with 7 nurse educators and 8 new nurses were conducted. Read More

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December 2018

Evaluation of an untargeted chemometric approach for the source inference of ignitable liquids in forensic science.

Forensic Sci Int 2018 Dec 5;295:8-18. Epub 2018 Dec 5.

UMR Ingénierie Procédés Aliments, AgroParisTech, Inra, Université Paris-Saclay, 91300 Massy, France. Electronic address:

Recent research efforts in the domain of fire debris analysis have been mainly oriented towards the development of innovative analytical procedures and chemometric approaches for the detection and classification of ignitable liquids in fire specimens according to the ASTM E1618. However, less attention has been brought to the question of the source inference of ignitable liquids. Infer the identity of source of ignitable liquids recovered from arson sites is still a challenging and ongoing research area. Read More

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December 2018

Acid sphingomyelinase: No potential as a biomarker for multiple sclerosis.

Mult Scler Relat Disord 2018 Nov 30;28:44-49. Epub 2018 Nov 30.

Department of Molecular Cell biology and Immunology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC - location VUmc, Amsterdam, The Netherlands.

Background: Multiple sclerosis (MS) lacks reliable biomarkers that reflect disease activity. Recent evidence suggests that an altered sphingolipid metabolism is associated with MS pathogenesis.

Objective: To explore acid sphingomyelinase (ASM) activity and altered sphingolipid metabolism as potential biomarkers in serum of MS patients, to predict active and progressive disease, and response to disease modifying therapy (DMT). Read More

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November 2018
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Attentional priming: recent insights and current controversies.

Curr Opin Psychol 2018 Nov 28;29:71-75. Epub 2018 Nov 28.

Icelandic Vision Laboratory, School of Humanitites and Social Sciences, University of Akureyri. Hafnarstræti 97, Akureyri IS600, Iceland.

Humans possess a primitive memory system for attention deployments that allows quick reorientation of visual attention to stimuli that are relevant to behavior at any given moment. We review recent evidence regarding such attentional priming effects from a number of different perspectives. We discuss recent findings on the time course and duration of such effects, the potential interaction of priming and top-down attentional guidance; how priming can be used to probe the nature of visual representations and attentional templates; findings on the basic nature of priming effects and recent relevant findings on so-called serial dependencies that share many characteristics with attentional priming. Read More

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November 2018
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Recent advances in bio-affinity chromatography for screening bioactive compounds from natural products.

J Pharm Biomed Anal 2018 Dec 7;165:182-197. Epub 2018 Dec 7.

Institute of Pharmaceutical Analysis, College of Pharmacy, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, China. Electronic address:

Natural products are one of the most important sources of leading compounds in drug discovery. Until now, rapid screening and identification of biologically active components from natural products remain a technical challenge. Bio-affinity chromatography (BAC) based approaches hold great promise in screening potential bioactive ligands from complex samples. Read More

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December 2018

PHQ-9: One factor or two?

Psychiatry Res 2018 Dec 7;271:532-534. Epub 2018 Dec 7.

Department of Psychology, University of Durham, Durham, United Kingdom; Clinical Psychology, Teesside University, Middlesbrough, United Kingdom. Electronic address:

The PHQ-9 has been found to be reliable and valid, but with both a single and two-factor structure suggested in the literature. This measure has not yet been subject to psychometric investigation using Mokken scale analysis. Confirmatory Factor Analysis (CFA) and Mokken analysis were performed on retrospective data from an NHS Trust. Read More

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December 2018

Physical exercise enhances adult cortical plasticity in a neonatal rat model of hypoxic-ischemic injury: Evidence from BOLD-fMRI and electrophysiological recordings.

Neuroimage 2018 Dec 12. Epub 2018 Dec 12.

Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, 06351, South Korea; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, South Korea; Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, South Korea; Animal Research and Molecular Imaging, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, 06351, South Korea; Department of Global Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea. Electronic address:

Neuroplasticity is considered essential for recovery from brain injury in developing brains. Recent studies indicate that it is especially effective during early postnatal development and during the critical period. The current study used functional magnetic resonance imaging (fMRI) and local field potential (LFP) electrophysiological recordings in rats that experienced neonatal hypoxic-ischemic (HI) injury during the critical period to demonstrate that physical exercise (PE) can improve cortical plasticity even when performed during adulthood, after the critical period. Read More

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December 2018

Synchronous occurrence of multiple distinct jaw lesions in Simpson-Golabi-Behmel Syndrome: A case report.

J Stomatol Oral Maxillofac Surg 2018 Dec 12. Epub 2018 Dec 12.

Associate Professor, Department of Pathology, Akdeniz University, Faculty of Medicine, Antalya, Turkey.

Simpson-Golabi-Behmel Syndrome (SGBS) is an X-linked overgrowth syndrome characterized by pre- and postnatal overgrowth, typical facial appearance and multiple visceral, skeletal, and neurological anomalies. There is only few information in the current literature, on clinical and particularly dentofacial findings due to recent identification of the syndrome and its clinical overlap with other overgrowth syndromes. The aim of this case report is to present dentofacial findings in a 16-year-old boy who had been diagnosed with SGBS. Read More

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December 2018

Zika Virus Diagnosis: Challenges and Solutions.

Clin Microbiol Infect 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine, University of Miami Miller School of Medicine. Miami, FL, 33133 USA.

Background: Since its sudden appearance and link to microcephaly in 2015, the number of PubMed references for Zika virus (ZIKV) has risen from 181 to 5,163, as of writing, with a vast proportion focused on the consequences of ZIKV infection during pregnancy. This level of attention underlies increased demand for sensitive and specific diagnostic tools able to assess risk to an unborn child, as well as to understand the dynamics and consequences of viral persistence.

Aim: Review the expanding knowledge on ZIKV persistence and diagnostic challenges and summarize current advancements in detection. Read More

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December 2018

Variety matters: Diverse functions of monocyte subtypes in vascular inflammation and atherogenesis.

Vascul Pharmacol 2018 Dec 12. Epub 2018 Dec 12.

Cardiology and Angiology, Philipps-University Marburg, Marburg, Germany. Electronic address:

Monocytes are important mediators of the innate immunity by recognizing and attacking especially bacterial pathogens but also play crucial roles in various inflammatory diseases, including vascular inflammation and atherosclerosis. Maturation, differentiation and function of monocytes have been intensively explored for a long time in innumerable experimental and clinical studies. Monocytes do not represent a uniform cell type but could be further subdivided into subpopulations with distinct features and functions. Read More

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December 2018

The role of SRC family kinases in FLT3 signaling.

Int J Biochem Cell Biol 2018 Dec 12. Epub 2018 Dec 12.

Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, Sweden; Lund Stem Cell Center, Department of Laboratory Medicine, Lund University, Lund, Sweden; Division of Oncology, Skåne University Hospital, Lund, Sweden. Electronic address:

The receptor tyrosine kinase FLT3 is expressed almost exclusively in the hematopoietic compartment. Binding of its ligand, FLT3 ligand (FL), induces dimerization and activation of its intrinsic tyrosine kinase activity. This leads to autophosphorylation of FLT3 on several tyrosine residues which constitute high affinity binding sites for signal transduction molecules. Read More

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December 2018
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The insulin-like growth factor-1 system in the adult mammalian brain and its implications in central maternal adaptation.

Front Neuroendocrinol 2018 Dec 12. Epub 2018 Dec 12.

MTA-ELTE Laboratory of Molecular and Systems Neurobiology, Department of Physiology and Neurobiology, Hungarian Academy of Sciences and Eötvös Loránd University, Budapest, Hungary; Laboratory of Neuromorphology, Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary; Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary. Electronic address:

Our knowledge on the bioavailability and actions of insulin-like growth factor-1 (IGF-1) has markedly expanded in recent years as novel mechanisms were discovered on IGF binding proteins (IGFBPs) and their ability to release IGF-1. The new discoveries allowed a better understanding of the endogenous physiological actions of IGF-1 and also its applicability in therapeutics. The focus of the present review is to summarize novel findings on the neuronal, neuroendocrine and neuroplastic actions of IGF-1 in the adult brain. Read More

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December 2018
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Technical Aspects of the Use of the Radial Artery in Coronary Artery Bypass Surgery.

Ann Thorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, United States.

Background: The radial artery (RA) has been used for coronary artery bypass surgery for more than 25 years. The recent confirmation of the clinical benefits associated with the use of the artery is likely to drive a new interest toward this conduit in the next few years METHODS: A group of surgeons with extensive experience in the systematic use of the RA summarize here the key technical aspects of the use of the conduit for coronary bypass operations.

Results: Preoperative evaluation of the ulnar collateral circulation and attention to the characteristics of the target vessel are key for the successful use of the radial artery. Read More

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December 2018

Molecular Mechanisms of Glutaredoxin Enzymes: Versatile Hubs for Thiol-Disulfide Exchange between Protein Thiols and Glutathione.

J Mol Biol 2018 Dec 12. Epub 2018 Dec 12.

School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.

The tripeptide glutathione (GSH) and its oxidized form glutathione disulfide (GSSG) constitute a key redox couple in cells. In particular, they partner protein thiols in reversible thiol-disulfide exchange reactions that act as switches in cell signaling and redox homeostasis. Disruption of these processes may impair cellular redox signal transduction and induce redox misbalances that are linked directly to aging processes and to a range of pathological conditions including cancer, cardiovascular diseases and neurological disorders. Read More

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December 2018

Young Cohorts of Russians Drink Less: Age-Period-Cohort Modelling of Alcohol Use Prevalence 1994-2016.

Addiction 2018 Dec 15. Epub 2018 Dec 15.

Laboratory for Studies in Economic Sociology, National Research University Higher School of Economics, 11 Myasnitskaya, Moscow, 101000, Russian Federation.

Background and aims Young Russians have been drinking less alcohol, and less strong spirits in particular, in recent years. This study aimed to disentangle age, period and birth cohort effects for the first time in Russia to improve our understanding of these trends. Design Age, period and cohort analysis of annual nationally representative repeated cross-sectional surveys (RLMS-HSE) using separate logistic models for each gender. Read More

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December 2018

Changes in injury incidences and causes in Swiss amateur soccer between the years 2004 and 2015.

Swiss Med Wkly 2018 Dec 15;148:w14690. Epub 2018 Dec 15.

Lamprecht und Stamm Sozialforschung und Beratung, Zürich, Switzerland.

Background: Injury prevention in amateur soccer has been promoted in recent years, but only a few studies have addressed long-term changes in injury incidence in amateur soccer. However, better knowledge of changes with respect to injury incidences and causes could make an important contribution to improving prevention strategies.

Aim: The aim of this study was to investigate the long-term development of injury incidence in Swiss amateur soccer with respect to level of play, injury causes and injury characteristics. Read More

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December 2018

Salivary gland tumors: Molecular characterization and therapeutic advances for metastatic disease.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Salivary gland cancers represent a rare group of tumors composed by over 20 histological subtypes. Initially treated as one single disease, its diagnosis, prognosis, and treatment are currently being stratified based on morphology. More recently, insight has been provided on the molecular characterization of each subtype, further improving diagnostic accuracy and paving the way for personalized therapy. Read More

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December 2018
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Developmental origins of murine γδ T cell subsets.

Immunology 2018 Dec 15. Epub 2018 Dec 15.

Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, London, E1 2AT.

Murine γδ T cells display diverse responses to pathogens and tumours through early provision of pro-inflammatory cytokines such as interleukin-17A (IL-17) and interferon-γ (IFNγ). Although it is now clear that acquisition of these cytokine-secreting effector fates is to a great extent developmentally pre-programmed in the thymus, the stages through which γδ progenitor cells transition, and the underlying mechanistic processes that govern these commitment events, are still largely unclear. Here, we review recent progress in the field, with particular consideration to how TCRγδ signalling impacts on developmental programs initiated prior to TCRγδ expression. Read More

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December 2018

Remission of hyperglycemia in spontaneously diabetic NOD mice upon transplant of microencapsulated human umbilical cord Wharton jelly-derived mesenchymal stem cells (hUCMS).

Xenotransplantation 2018 Dec 15:e12476. Epub 2018 Dec 15.

Section of Cardiovascular, Endocrine and Metabolic Clinical Physiology, and Laboratory for Endocrine Cell Transplants and Biohybrid Organs, Department of Medicine, University of Perugia, Perugia, Italy.

Background: Our previous in vitro demonstration of the immunoregulatory effects of microencapsulated hUCMS on human peripheral blood mononuclear cells (PBMCs) extracted from patients with recent onset, type 1 diabetes mellitus (DM), prompted us to test our product for xenograft (TX) in non obese diabetic (NOD) mice with spontaneous DM.

Methods: We transplanted microencapsulated hUCMS into the peritoneal cavity of NOD mice with either severe or mild DM. Blood glucose (BG) levels were monitored following TX, in either basal or upon glucose stimulation. Read More

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December 2018

Periventricular Microglial Cells Interact with Dividing Precursor Cells in the Nonhuman Primate and Rodent Prenatal Cerebral Cortex.

J Comp Neurol 2018 Dec 15. Epub 2018 Dec 15.

Department of Pediatrics, School of Medicine, UC Davis, Davis, CA.

Cortical proliferative zones have been studied for over 100 years, yet recent data has revealed that microglial cells constitute a sizeable proportion of ventricular zone cells during late stages of cortical neurogenesis. Microglia begin colonizing the forebrain after neural tube closure and during later stages of neurogenesis populate regions of the developing cortex that include the proliferative zones. We previously showed that microglia regulate the production of cortical cells by phagocytosing neural precursor cells (NPCs), but how microglia interact with NPCs remains poorly understood. Read More

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December 2018

From avatars to body swapping: The use of virtual reality for assessing and treating body-size distortion in individuals with anorexia.

J Clin Psychol 2018 Dec 15. Epub 2018 Dec 15.

Department of Psychology, Università Cattolica del Sacro Cuore, Milan, Italy.

In the last 30 years, virtual reality (VR) has offered innovative solutions for assessing and treating body representation disturbances in anorexia nervosa (AN). The most recent and innovative trend is the exploitation of the so-called VR-based body swapping illusion. The aim of this case study was to report the use of this VR protocol within a multidisciplinary treatment of AN. Read More

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December 2018

Key Elements in Adverse Drug Reactions Safety Signals: Application of Legal Strategies.

Cancer Treat Res 2019 ;171:47-59

University of South Carolina, Columbia, SC, USA.

Adverse drug reactions, or unintended and harmful outcomes related to the administration of a pharmaceutical product, are a major public health concern, particularly for cancer patients. If counted as a separate cause of death, adverse drug reactions would represent the fourth leading cause of death in the United States. Several legal strategies are available to help mitigate their occurrences and to compensate victims for the harm that results from adverse events. Read More

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January 2019
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Existence and features of the myodural bridge in Gallus domesticus: indication of its important physiological function.

Anat Sci Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Anatomy, College of Basic Medicine, Dalian Medical University, Dalian, China.

The myodural bridge (MDB) is a dense connective tissue that connects muscles with the cervical spinal dura mater via the posterior atlanto-occipital and atlato-axial interspaces. To date, the physiological function of the MDB has not been fully elucidated. Recent studies have identified the presence of the MDB in mammals, but very little information is available on the existence of the MDB in avifauna. Read More

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December 2018

Recent Progress on Functional Genomics Research of Enterovirus 71.

Virol Sin 2018 Dec 14. Epub 2018 Dec 14.

Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

Enterovirus 71 (EV71) is one of the main pathogens that causes hand-foot-and-mouth disease (HFMD). HFMD caused by EV71 infection is mostly self-limited; however, some infections can cause severe neurological diseases, such as aseptic meningitis, brain stem encephalitis, and even death. There are still no effective clinical drugs used for the prevention and treatment of HFMD. Read More

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December 2018
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Strongyloides stercoralis infection in imported and local dogs in Switzerland: from clinics to molecular genetics.

Parasitol Res 2018 Dec 14. Epub 2018 Dec 14.

Small Animal Clinic, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Strongyloides stercoralis is a worldwide-distributed intestinal nematode affecting mainly humans and dogs. Canine strongyloidosis is generally characterised by diarrhoea, malabsorption and bronchopneumonia, and may be fatal in cases of impaired immunity. In recent years, molecular and epidemiological studies suggested that host-adapted populations of S. Read More

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December 2018

SIA: a scalable interoperable annotation server for biomedical named entities.

J Cheminform 2018 Dec 14;10(1):63. Epub 2018 Dec 14.

DFKI Language Technology Lab, Alt-Moabit 91c, Berlin, Germany.

Recent years showed a strong increase in biomedical sciences and an inherent increase in publication volume. Extraction of specific information from these sources requires highly sophisticated text mining and information extraction tools. However, the integration of freely available tools into customized workflows is often cumbersome and difficult. Read More

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December 2018

Imaging in neurointerventional stroke treatment: review of the recent trials and what your neurointerventionalist wants to know from emergency radiologists.

Emerg Radiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiology and Biomedical Imaging, University of California San Francisco School of Medicine, 550 16th. Street, San Francisco, CA, 94158, USA.

Stroke is one of the leading causes of death and disability worldwide. Standard treatment for stroke is intravenous (IV) injection of tissue plasminogen activator (t-PA) rapidly after symptom onset. However, there are limitations of IV t-PA treatment, such as a short time window for administration and risk for hemorrhage. Read More

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December 2018

Chaos-embedded particle swarm optimization approach for protein-ligand docking and virtual screening.

J Cheminform 2018 Dec 14;10(1):62. Epub 2018 Dec 14.

Department of Computer and Information Science, University of Macau, Avenida da Universidade, Taipa, Macau, China.

Background: Protein-ligand docking programs are routinely used in structure-based drug design to find the optimal binding pose of a ligand in the protein's active site. These programs are also used to identify potential drug candidates by ranking large sets of compounds. As more accurate and efficient docking programs are always desirable, constant efforts focus on developing better docking algorithms or improving the scoring function. Read More

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December 2018

Rational combination of cancer immunotherapy in melanoma.

Virchows Arch 2018 Dec 14. Epub 2018 Dec 14.

Maria Sklodowska-Curie Institute, Oncology Center, Warsaw, Poland.

The recent advances in cancer immunotherapy with unprecedented success in therapy of advanced melanoma represent a turning point in the landscape of melanoma treatment. Given the complexity of activation of immunological system and the physiologic multifactorial homeostatic mechanisms controlling immune responses, combinatorial strategies are eagerly needed in melanoma therapy. Nevertheless, rational selection of immunotherapy combinations should be more biomarker-guided, including not only the cancer immunogram, PD-L1 expression, interferon gene expression signature, mutational burden, and tumor infiltration by CD8+ T cells but also intratumoral T cell exhaustion and microbiota composition. Read More

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December 2018
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Electrophysiology of the pancreatic islet β-cell sweet taste receptor TIR3.

Pflugers Arch 2018 Dec 14. Epub 2018 Dec 14.

Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.

Over recent years, the presence of the sweet taste receptor TIR3 in rodent and human insulin-producing pancreatic islet β-cells was documented. The activation of this receptor by sweet-tasting sucralose mimics several biochemical and functional effects of D-glucose in the β-cells. The present study extends this analogy to the bioelectrical response of β-cells. Read More

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December 2018

[Radiological imaging to assess individual cardiovascular risk].

Radiologe 2018 Dec 14. Epub 2018 Dec 14.

Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.

Clinical/methodical Issue: Radiologic imaging for the assessment of individual cardiovascular risk.

Standard Radiological Methods: The correct estimation of the individual cardiovascular risk is prerequisite for the prevention of cardiovascular diseases. Here, extensive evidence is available for coronary calcium scans as well as coronary CT angiography (CTA). Read More

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December 2018

Longitudinal airway remodeling in active and past smokers in a lung cancer screening population.

Eur Radiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.

Objectives: To longitudinally investigate smoking cessation-related changes of quantitative computed tomography (QCT)-based airway metrics in a group of heavy smokers.

Methods: CT scans were acquired in a lung cancer screening population over 4 years at 12-month intervals in 284 long-term ex-smokers (ES), 405 continuously active smokers (CS), and 31 subjects who quitted smoking within 2 years after baseline CT (recent quitters, RQ). Total diameter (TD), lumen area (LA), and wall percentage (WP) of 1st-8th generation airways were computed using airway analysis software. Read More

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December 2018

Recent Advances on Relationship Between Inorganic Phosphate and Pathologic Calcification: Is Calcification After Breast Augmentation with Fat Grafting Correlated with Locally Increased Concentration of Inorganic Phosphate?

Aesthetic Plast Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Aesthetic and Reconstructive Breast Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, 33 Badachu Road, Shijingshan District, Beijing, 100144, China.

Background: Pathologic calcification has frequently occurred after breast augmentation with fat grafting as well as other conditions such as breast cancer, trauma, myocardial infarction, arteriosclerosis and even after reduction mammoplasty. Inorganic phosphate, correlated with fat metabolism, is an important factor that induces pathologic calcification such as vascular calcification.

Methods: A literature search was conducted using PubMed with the keywords: calcification, inorganic phosphate, fat. Read More

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December 2018

The Use of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine: A Comprehensive Review.

Aesthetic Plast Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Molecular Medicine and Genetics, Research Center for Molecular Medicine, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Introduction: In recent years, platelet-rich plasma (PRP) has emerged as a promising autologous biological treatment modality for the use in aesthetic and regenerative medicine. PRP is a high concentration of platelets derived from whole blood which is isolated by centrifugation to separate and concentrate platelet-containing plasma from red blood cells. PRP comprises hundreds of bioactive proteins, including growth factors, peptides, and cytokines that stimulate healing of skin and soft tissues. Read More

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December 2018
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[First-line treatment of multiple myeloma].

Internist (Berl) 2018 Dec 14. Epub 2018 Dec 14.

Medizinische Klinik V, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Deutschland.

Within the last two decades the therapeutic options for newly diagnosed multiple myeloma have changed dramatically. The implementation of high-dose chemotherapy with melphalan and subsequent autologous blood stem cell transplantation initially led to prolonged survival in younger, fit patients. Furthermore, recent data suggest that patients with high-risk disease seem to benefit most from tandem transplantation approaches. Read More

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December 2018

[Critical care management of the potential organ donor : Current recommendation for adults].

Med Klin Intensivmed Notfmed 2018 Dec 14. Epub 2018 Dec 14.

Klinik für Anästhesiologie, Anästhesie, Intensiv‑, Notfall- und Schmerzmedizin, Universitätsmedizin Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Deutschland.

The shortage of donor organs has not improved in recent years. To increase the number and success of transplantation it is crucial to optimize the processes of early identification of potential organ donors and structured critical care management. The therapy starts long before brain death is diagnosed. Read More

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December 2018

The role of recessive inheritance in early-onset epileptic encephalopathies: a combined whole-exome sequencing and copy number study.

Eur J Hum Genet 2018 Dec 14. Epub 2018 Dec 14.

Institute of Medical Genetics, University of Zurich, Schlieren-Zurich, 8952, Switzerland.

Early-onset epileptic encephalopathy (EE) and combined developmental and epileptic encephalopathies (DEE) are clinically and genetically heterogeneous severely devastating conditions. Recent studies emphasized de novo variants as major underlying cause suggesting a generally low-recurrence risk. In order to better understand the full genetic landscape of EE and DEE, we performed high-resolution chromosomal microarray analysis in combination with whole-exome sequencing in 63 deeply phenotyped independent patients. Read More

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December 2018

Global mapping for the epidemiology of paediatric spinal cord damage: towards a living data repository.

Spinal Cord 2018 Dec 14. Epub 2018 Dec 14.

Kids Rehab, The Children's Hospital at Westmead, Westmead, NSW, Australia.

Study Design: Literature review.

Objectives: Globally map key paediatric spinal cord damage epidemiological measures and provide a framework for an ongoing repository of data.

Setting: Worldwide, initiative of ISCoS Prevention Committee. Read More

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December 2018

A novel role for E2F3b in regulating cocaine action in the prefrontal cortex.

Neuropsychopharmacology 2018 Dec 14. Epub 2018 Dec 14.

Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Drug abuse is a multifaceted disorder that involves maladaptive decision making. Long-lasting changes in the addicted brain are mediated by a complex circuit of brain reward regions. The prefrontal cortex (PFC) is one region in which chronic drug exposure changes expression and function of upstream transcriptional regulators to alter drug responses and aspects of the addicted phenotype. Read More

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December 2018

Miniscule differences between sex chromosomes in the giant genome of a salamander.

Sci Rep 2018 Dec 14;8(1):17882. Epub 2018 Dec 14.

Department of Biology, University of Kentucky, Lexington, KY, USA.

In the Mexican axolotl (Ambystoma mexicanum), sex is determined by a single Mendelian factor, yet its sex chromosomes do not exhibit morphological differentiation typical of many vertebrate taxa that possess a single sex-determining locus. As sex chromosomes are theorized to differentiate rapidly, species with undifferentiated sex chromosomes provide the opportunity to reconstruct early events in sex chromosome evolution. Whole genome sequencing of 48 salamanders, targeted chromosome sequencing and in situ hybridization were used to identify the homomorphic sex chromosome that carries an A. Read More

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December 2018

Along-shelf connectivity and circumpolar gene flow in Antarctic silverfish (Pleuragramma antarctica).

Sci Rep 2018 Dec 14;8(1):17856. Epub 2018 Dec 14.

Department of Biology, University of Padua, Via G. Colombo 3, Padua, 35121, Italy.

The Antarctic silverfish (Pleuragramma antarctica) is a critically important forage species with a circumpolar distribution and is unique among other notothenioid species for its wholly pelagic life cycle. Previous studies have provided mixed evidence of population structure over regional and circumpolar scales. The aim of the present study was to test the recent population hypothesis for Antarctic silverfish, which emphasizes the interplay between life history and hydrography in shaping connectivity. Read More

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December 2018

Spike-timing-dependent plasticity learning of coincidence detection with passively integrated memristive circuits.

Nat Commun 2018 Dec 14;9(1):5311. Epub 2018 Dec 14.

Electrical and Computer Engineering Department, UC Santa Barbara, Santa Barbara, CA, 93106-9560, USA.

Spiking neural networks, the most realistic artificial representation of biological nervous systems, are promising due to their inherent local training rules that enable low-overhead online learning, and energy-efficient information encoding. Their downside is more demanding functionality of the artificial synapses, notably including spike-timing-dependent plasticity, which makes their compact efficient hardware implementation challenging with conventional device technologies. Recent work showed that memristors are excellent candidates for artificial synapses, although reports of even simple neuromorphic systems are still very rare. Read More

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December 2018

Injury factors alter miRNAs profiles of exosomes derived from islets and circulation.

Aging (Albany NY) 2018 Dec 14. Epub 2018 Dec 14.

Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.

Islets damage is a major abnormality underling diabetes. Recent studies suggested the value of exosomes in diagnosis. This study aimed to investigate the impact of injury factors on the miRNA profiles of islet exosomes and determine whether circulating exosomal miRNAs is suitable as biomarkers of islets damage. Read More

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December 2018

Drug adherence and drug-related problems in pharmacotherapy for lower urinary tract symptoms related to benign prostatic hyperplasia.

J Physiol Pharmacol 2018 Aug 9;69(4). Epub 2018 Dec 9.

Urological Outpatient Clinic, Warsaw, Poland.

Lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) is one of the most common urinary disorders in elderly men. In recent years, pharmacotherapy of BPH has increased the efficacy, including combination treatment mostly with two drug classes, namely, 5-α-reductase inhibitors and α-1-adrenolytics (alpha blockers) with a different pharmacological activity. Although pharmacological treatment of BPH is a success story in urology, daily practice suggests that several medical needs remain unmet. Read More

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Urinary neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, uromodulin, and cystatin C concentrations in an experimental rat model of ascending acute kidney injury induced by pyelonephritis.

J Physiol Pharmacol 2018 Aug 9;69(4). Epub 2018 Dec 9.

Department of Pathophysiology, Jagiellonian University Medical College, Cracow, Poland.

Recent evidence suggests that neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), cystatin C (CysC), uromodulin (UMOD), and some interleukins (IL-6 and IL-18) can be considered as diagnostic markers of acute kidney injury (AKI). The aim of this study was to verify the applicability of four urinary (u) markers, namely uNGAL, uKIM-1, uCysC, and uUMOD, for the diagnosis of ascending AKI induced by bacterial pyelonephritis. The study included 30 female rats that were divided into three groups (n = 10 each) and were inoculated transurethrally with various doses of Escherichia coli to induce isolated pyelonephritis (group 1, 10 CFU/ml), pyelonephritis-induced AKI (group 2, 10 CFU/ml), or AKI and urosepsis (group 3, 10 CFU/ml). Read More

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Supersaturated silica-lipid hybrid (super-SLH) oral drug delivery systems: Balancing drug loading and in vivo performance.

J Pharmacol Exp Ther 2018 Dec 14. Epub 2018 Dec 14.

University of South Australia;

Supersaturated silica-lipid hybrid (super-SLH) drug carriers are a recent strategy to improve the drug loading of oral solid lipid based formulations, however they are yet to be studied This study investigates the pharmacokinetics (PK) of super-SLH containing ibuprofen (IBU) as a model drug, analysing the influence of supersaturated drug loading on oral bioavailability and assessing correlation (IVIVC). In addition, super-SLH was directly compared to spray dried SLH and Nurofen, to explore its potential advantages over the well-established and commercial formulations. Fasted male Sprague-Dawley rats were administered formulation suspensions (10 mg/kg IBU) via oral gavage and blood samples were acquired and analysed for drug content over 24 hours. Read More

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December 2018

Evidence for a southward autumn migration of nocturnal noctuid moths in central Europe.

J Exp Biol 2018 Dec 14;221(Pt 24). Epub 2018 Dec 14.

Department of Biology, Lund University, 22362 Lund, Sweden.

Insect migrations are spectacular natural events and resemble a remarkable relocation of biomass between two locations in space. Unlike the well-known migrations of daytime flying butterflies, such as the painted lady () or the monarch butterfly (), much less widely known are the migrations of nocturnal moths. These migrations - typically involving billions of moths from different taxa - have recently attracted considerable scientific attention. Read More

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December 2018

Effectiveness of self-testing kits availability on improving HIV testing frequency for chinese men who have sex with men and their sexual partners: a protocol for a multicenter randomised controlled trial.

BMJ Open 2018 Dec 14;8(12):e024423. Epub 2018 Dec 14.

Xiangya Nursing School of Central South University, Changsha, China.

Introduction: HIV epidemic is increasing among men who have sex with men (MSM) in China, yet HIV testing uptake remains low. As an emerging approach, HIV self-testing (HIVST) has the potential to promote HIV testing coverage and frequency in this population. However, evidence of the effectiveness on implementation of HIVST among Chinese MSM and their sexual partners is scarce. Read More

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December 2018

Qualitative exploration of sociocultural determinants of health inequities of Dalit population in Dhaka City, Bangladesh.

BMJ Open 2018 Dec 14;8(12):e022906. Epub 2018 Dec 14.

Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.

Objectives: In recent years, Bangladesh has made remarkable advances in health outcomes; however, the benefits of these gains are unequally shared among citizens and population groups. Dalits ( sweepers), a marginalised traditional working community, have relatively poor access to healthcare services. This study sought to explore the sociopolitical and cultural factors associated with health inequalities among Dalits in an urban setting. Read More

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December 2018

Vacuolar phosphate transporters contribute to systemic phosphate homeostasis vital for reproductive development in Arabidopsis.

Plant Physiol 2018 Dec 14. Epub 2018 Dec 14.

University of California CITY: Berkeley STATE: California POSTAL_CODE: 94720 United States Of America [US]

Vacuolar storage of phosphate (Pi) is essential for Pi homeostasis in plants. Recent studies have identified a family of vacuolar Pi transporters, VPTs (PHT5s), responsible for vacuolar sequestration of Pi. We report here that both VPT1 and VPT3 contribute to cytosol-to-vacuole Pi partitioning. Read More

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December 2018
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