1,021,657 results match your criteria Recent Patents on Electrical Engineering [Journal]


YY1 regulates cancer cell immune resistance by modulating PD-L1 expression.

Drug Resist Updat 2019 Apr 9;43:10-28. Epub 2019 Apr 9.

Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, United States. Electronic address:

Recent advances in the treatment of various cancers have resulted in the adaptation of several novel immunotherapeutic strategies. Notably, the recent intervention through immune checkpoint inhibitors has resulted in significant clinical responses and prolongation of survival in patients with several therapy-resistant cancers (melanoma, lung, bladder, etc.). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13687646193001
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http://dx.doi.org/10.1016/j.drup.2019.04.001DOI Listing
April 2019
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A multi-scale data fusion framework for bone age assessment with convolutional neural networks.

Comput Biol Med 2019 Mar 19;108:161-173. Epub 2019 Mar 19.

Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC, Canada.

Bone age assessment (BAA) has various clinical applications such as diagnosis of endocrine disorders and prediction of final adult height for adolescents. Recent studies indicate that deep learning techniques have great potential in developing automated BAA methods with significant advantages over the conventional methods based on handcrafted features. In this paper, we propose a multi-scale data fusion framework for bone age assessment with X-ray images based on non-subsampled contourlet transform (NSCT) and convolutional neural networks (CNNs). Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.03.015DOI Listing

Natural source zone depletion of LNAPL: A critical review supporting modelling approaches.

Water Res 2019 Apr 7;157:630-646. Epub 2019 Apr 7.

CSIRO Land and Water, Private Bag No. 5, Wembley, WA, 6913, Australia.

Natural source zone depletion (NSZD) of light non-aqueous phase liquids (LNAPLs) includes partitioning, transport and degradation of LNAPL components. NSZD is being considered as a site closure option during later stages of active remediation of LNAPL contaminated sites, and where LNAPL mass removal is limiting. To ensure NSZD meets compliance criteria and to design enhanced NSZD actions if required, residual risks posed by LNAPL and its long term behaviour require estimation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00431354193029
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http://dx.doi.org/10.1016/j.watres.2019.04.001DOI Listing
April 2019
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Targeted protein degradation: elements of PROTAC design.

Curr Opin Chem Biol 2019 Apr 16;50:111-119. Epub 2019 Apr 16.

Molecular, Cellular, and Developmental Biology Department, Yale University, 219 Prospect Street, KBT 400, New Haven, CT, 06511, United States. Electronic address:

Targeted protein degradation using Proteolysis Targeting Chimeras (PROTACs) has emerged as a novel therapeutic modality in drug discovery. PROTACs mediate the degradation of select proteins of interest (POIs) by hijacking the activity of E3 ubiquitin ligases for POI ubiquitination and subsequent degradation by the 26S proteasome. This hijacking mechanism has been used to degrade various types of disease-relevant POIs. Read More

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http://dx.doi.org/10.1016/j.cbpa.2019.02.022DOI Listing

Amino acid conformations control the morphological and chiral features of the self-assembled peptide nanostructures: Young investigators perspective.

J Colloid Interface Sci 2019 Apr 6;548:244-254. Epub 2019 Apr 6.

State Key Laboratory of Heavy Oil Processing and Centre for Bioengineering and Biotechnology, China University of Petroleum (East China), 66 Changjiang West Road, Qingdao, China. Electronic address:

Hypothesis: A variety of nanostructures with different chiral features can be self-assembled from short peptides with highly similar sequences. We hypothesize that these supramolecular nanostructures are ruled by the constituent amino acid residues which adopt their conformations under the influence of intra-/inter-molecular interactions during peptide self-assembly.

Approach: Through reviewing recent advances in the self-assembly of short peptides and focusing on the relationship between amino acid conformations, peptide secondary structures and intra-/inter-molecular interactions within the supramolecular architectures, we aim to rationalize the complex interactive processes involved in the self-assembly of short, designed peptides. Read More

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http://dx.doi.org/10.1016/j.jcis.2019.04.019DOI Listing

Quality of life and correlating factors in children, adolescents with epilepsy, and their caregivers: A cross-sectional multicenter study from Germany.

Seizure 2019 Mar 29;69:92-98. Epub 2019 Mar 29.

Epilepsy Center Hessen and Department of Neurology, Philipps-University Marburg, Marburg (Lahn), Germany; Epilepsy Center Frankfurt Rhine-Main and Department of Neurology, Goethe University Frankfurt, Frankfurt am Main, Germany; LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, Frankfurt am Main, Germany. Electronic address:

Purpose: To identify factors correlating with poorer quality of life (QoL) in children and adolescents with epilepsy and regarding QoL and depression of their caregivers in Germany.

Method: A cross-sectional multicenter study on QoL and depression was performed in two representative German states (Hessen and Schleswig-Holstein). Variance analysis, linear regression, and bivariate correlation were used to identify correlating factors for poorer QoL and symptoms of depression. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183052
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http://dx.doi.org/10.1016/j.seizure.2019.03.016DOI Listing
March 2019
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Spatiotemporal patterns and characteristics of remotely sensed region heat islands during the rapid urbanization (1995-2015) of Southern China.

Sci Total Environ 2019 Apr 11;674:242-254. Epub 2019 Apr 11.

Department of Geosciences and Natural Resource Management, Faculty of Science, University of Copenhagen, Copenhagen 1958, Denmark. Electronic address:

Urban agglomeration has become the most salient feature of global urbanization in recent decades, while spatiotemporal patterns and evolution remain poorly understood in urban agglomerations, which limit the decision-makers to make more informed decisions to improve the regional environment. Here we selected one of the most rapidly urbanized regions in the world - Pearl River Delta Metropolitan Region (PRDR), located in southern China, as the case. Landsat images spanning from 1995 to 2015 were used to retrieve land surface temperature (LST). Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.088DOI Listing

Zhixiong Capsule (ZXC), a traditional Chinese patent medicine, prevents atherosclerotic plaque formation in rabbit carotid artery and the related mechanism investigation based on network pharmacology and biological research.

Phytomedicine 2018 Dec 7;59:152776. Epub 2018 Dec 7.

School of Traditional Chinese Material, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Background And Aims: Chinese patent medicine Zhixiong Capsule (ZXC) has been used in clinical treatment against blood stasis-induced dizziness and headache for many years in China.

Hypothesis/purpose: Recent clinical observations demonstrated a good efficacy of ZXC against atherosclerotic plaque formation in carotid arteries. The aims of this study were to verify the plaque-preventing efficacy of ZXC in animals and to investigate the underlying mechanisms. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.11.036DOI Listing
December 2018

Effect of EZH2 knockdown on preimplantation development of porcine parthenogenetic embryos.

Theriogenology 2019 Apr 14;132:95-105. Epub 2019 Apr 14.

State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, PR China. Electronic address:

The EZH2 protein endows the polycomb repressive complex 2 (PRC2) with histone lysine methyltransferase activity that is associated with transcriptional repression. Recent investigations have documented crucial roles for EZH2 in mediating X-inactivation, stem cell pluripotency and cancer metastasis. However, there is little evidence demonstrating the maternal effect of EZH2 on porcine preimplantation development. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.04.007DOI Listing

TREO Aortic Endograft Demonstrates Significant Aneurysmal Sac Shrinkage.

J Surg Res 2019 Apr 17;241:48-52. Epub 2019 Apr 17.

Division of Vascular Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, New York. Electronic address:

Background: Aneurysmal sac shrinkage is associated with successful aneurysm repair after endovascular aortic repair (EVAR). There are a variety of approved aortic endografts, with a recent study demonstrating increased sac shrinkage in certain endografts compared with others. The TREO endograft (Terumo Aortic Ltd, Renfrewshire, Scotland, UK) is being evaluated for use in EVAR, with preliminary data demonstrating high rates of success. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193016
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http://dx.doi.org/10.1016/j.jss.2019.03.048DOI Listing
April 2019
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Integration of biological systems with electronic-mechanical assemblies.

Acta Biomater 2019 Apr 17. Epub 2019 Apr 17.

Department of Materials Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA; Department of Engineering Science and Mechanics, and Materials Research Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. Electronic address:

Biological systems continuously interact with the surrounding environment because they are dynamically evolving. The interaction is achieved through mechanical, electrical, chemical, biological, thermal, optical, or a synergistic combination of these cues. To provide a fundamental understanding of the interaction, recent efforts that integrate biological systems with the electronic-mechanical assemblies create unique opportunities for simultaneous monitoring and eliciting the responses to the biological system. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193027
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http://dx.doi.org/10.1016/j.actbio.2019.04.032DOI Listing
April 2019
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A Single-Cell RNA Sequencing Profiles the Developmental Landscape of Arabidopsis Root.

Mol Plant 2019 Apr 17. Epub 2019 Apr 17.

National Key Laboratory of Plant Molecular Genetics (NKLPMG), CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology (SIPPE), Shanghai 200032, P. R. China; University of Chinese Academy of Sciences, Shanghai 200032, P. R. China; ShanghaiTech University, Shanghai 200031, P. R. China. Electronic address:

Cells have the inherent heterogeneity. Recent advances in the single-cell gene expression studies enable us to explore transcriptional regulation in dynamic development processes and highly heterogeneous cell populations. Using high-throughput single-cell RNA sequencing (scRNA-seq) assay, we found that the cells in Arabidopsis root are highly heterogeneous in their transcriptomes. Read More

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http://dx.doi.org/10.1016/j.molp.2019.04.004DOI Listing
April 2019
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Psychotropic polypharmacy reconsidered: Between-class polypharmacy in the context of multimorbidity in the treatment of depressive disorders.

J Affect Disord 2019 Apr 8;252:450-457. Epub 2019 Apr 8.

Department of Psychiatry, School of Medicine, Yale University, New Haven, CT, United States; Veterans Affairs (VA) New England Mental Illness Research, Education and Clinical Centers (MIRECC), West Haven, CT, United States; Veterans Affairs (VA) Connecticut Healthcare System, West Haven, CT, United States.

Objectives: Both psychiatric polypharmacy and multimorbidity are common in depressed adults. We examine recent patterns of psychotropic polypharmacy with attention to concurrent multimorbidity in the treatment of depressive disorders in outpatient psychiatric care.

Methods: Data from the 2006-2015 National Ambulatory Medical Care Survey offer nationally representative samples of office-based psychiatric care in adults with depressive disorders (ICD-9-CM codes 296. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.018DOI Listing

Effectiveness of shortened time interval to postpartum visit in improving postpartum attendance: Design and rationale for a randomized controlled trial.

Contemp Clin Trials 2019 Apr 17. Epub 2019 Apr 17.

The University of Vermont College of Medicine, Division of Reproductive Endocrinology & Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Smith 410, Main Campus, 111, Colchester, Avenue Burlington, VT 05401, USA.

Background/aims: Recent evidence suggests that there are numerous benefits to scheduling postpartum visits as early as 3 weeks post-delivery. However, findings are not conclusive due to methodological limitations. This report discusses the unique aspects of a randomized controlled trial's (RCT) design, intervention, and strategies to maintain participant retention. Read More

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http://dx.doi.org/10.1016/j.cct.2019.04.012DOI Listing

Innovative techniques for the treatment of adult strabismus.

J AAPOS 2019 Apr 17. Epub 2019 Apr 17.

Department of Ophthalmology, Duke Eye Center, Duke University, Durham, North Carolina; Department of Ophthalmology, University of California, Los Angeles; Doheny Eye Institute, Los Angeles, California.

Adult strabismus is often characterized by surgical complexity. In recent years, several innovative techniques for the management of complex strabismus have been developed. Strabismus surgeons should understand the indications for various strabismus surgical techniques in the management of these difficult cases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10918531193008
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http://dx.doi.org/10.1016/j.jaapos.2018.10.018DOI Listing
April 2019
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Bartonella diversity and zoonotic potential in indigenous Tete Veld rats (Aethomys ineptus) from South Africa.

Infect Genet Evol 2019 Apr 17. Epub 2019 Apr 17.

Mammal Research Institute (MRI), Department of Zoology and Entomology, University of Pretoria, Private Bag 20, Hatfield 0028, South Africa. Electronic address:

Bartonellosis is a vector-borne disease that is often misdiagnosed due to a broad range of clinical symptoms, compounded by a lack of awareness regarding the prevalence, diversity and public health impacts of regional strains. Despite recent PCR-based confirmation of Bartonella in 9.7% of non-malarial, acute febrile patients in South Africa, data regarding reservoirs of infection are limited. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.04.012DOI Listing

Microglial alterations induced by psychoactive drugs: A possible mechanism in substance use disorder?

Semin Cell Dev Biol 2019 Apr 17. Epub 2019 Apr 17.

Department of Dynamic and Clinical Psychology, University of Rome "La Sapienza," Via degli Apuli 1, 00185, Rome, Italy; IRCCS Santa Lucia Foundation, Via Fosso di Fiorano 64, 00143, Rome, Italy. Electronic address:

Recently, the xenobiotic hypothesis has implicated the immune system in targeting substances of abuse as foreign molecules and stimulating inflammatory responses. Microglial cells are the resident immune cells of the central nervous system and function in homeostatic surveillance. Microglial changes that are induced by exposure to substances of abuse appear to mediate in part the establishment of addiction and the persistence of drug-mediated biological and behavioral changes. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.03.008DOI Listing

Protective function of autophagy during VLCFA-induced cytotoxicity in a neurodegenerative cell model.

Free Radic Biol Med 2019 Apr 17. Epub 2019 Apr 17.

Université de Bourgogne Franche-Comté, Dijon, F-21000, France; Team 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA 7270, Inserm, F-21000, Dijon, France. Electronic address:

In recent years, a particular interest has focused on the accumulation of fatty acids with very long chains (VLCFA) in the occurrence of neurodegenerative diseases such as Alzheimer's disease, multiple sclerosis or dementia. Indeed, it seems increasingly clear that this accumulation of VLCFA in the central nervous system is accompanied by a progressive demyelination resulting in death of neuronal cells. Nevertheless, molecular mechanisms by which VLCFA result in toxicity remain unclear. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.016DOI Listing

The impact of recent advances in lipidomics and redox lipidomics on dermatological research.

Free Radic Biol Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Medical University of Vienna, Austria; Christian Doppler Laboratory for the Biotechnology of Skin Aging, Vienna, Austria.

Dermatological research is a major beneficiary of the rapidly developing advances in lipid analytic technology and of bioinformatic tools which help to decipher and interpret the accumulating big lipid data. At its interface with the environment, the epidermis develops a blend of lipids that constitutes the epidermal lipid barrier, essential for the protection from water loss and entry of dangerous noxae. Apart from their structural role in the barrier, novel intra- and inter-cellular signaling functions of lipids and their oxidation products have been uncovered in most cutaneous cell types over the last decades, and the discovery rate has been boosted by the advent of high resolution and -throughput mass spectrometric techniques. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08915849193015
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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.019DOI Listing
April 2019
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Role of astrocytes-derived D-serine in PFOS-induced neurotoxicity through NMDARs in the rat primary hippocampal neurons.

Toxicology 2019 Apr 17. Epub 2019 Apr 17.

Department of Environmental Health and Toxicology, School of Public Health, Dalian Medical University, Dalian 116044, China; Dalian Key Laboratory of Hematology, Liaoning Hematopoietic Stem Cell Transplantation Medical Center, Department of Environmental Health and Toxicology, School of Public Health, Dalian Medical University. Dalian, Liaoning, 116044, China. Electronic address:

Perfluorooctane sulfonate (PFOS) is one of the perfluorinated compounds (PFCs), and has been used in industrial and consumer products. It has already been shown that PFOS could be detected in the environmental media and biological species including humans, due to its resistance to environmental degradation. PFOS is known to induce a series of adverse impacts on human health, e. Read More

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http://dx.doi.org/10.1016/j.tox.2019.04.007DOI Listing

Anti-tumor properties of methoxylated analogues of resveratrol in malignant MCF-7 but not in non-tumorigenic MCF-10A mammary epithelial cell lines.

Toxicology 2019 Apr 17. Epub 2019 Apr 17.

Institute for Risk Assessment Sciences, Toxicology Department, Utrecht University, Yalelaan 104, 3584 CM, Utrecht, the Netherlands.

Resveratrol is a plant-derived polyphenol that is known for its anti-inflammatory and anti-tumorigenic properties in in vitro and in vivo models. Recent studies show that some resveratrol analogues might be more potent anti-tumor agents, which may partly be attributed to their ability to activate the aryl hydrocarbon receptor (AHR). Here, the anti-tumorigenic properties of resveratrol and structural analogues oxyresveratrol, pinostilbene, pterostilbene and tetramethoxystilbene (TMS) were studied in vitro, using in the malignant human MCF-7 breast cancer cell line and non-tumorigenic breast epithelial cell line MCF-10 A. Read More

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http://dx.doi.org/10.1016/j.tox.2019.04.009DOI Listing

Behavioral and electctrophysiological evidence for enhanced sensitivity to subtle variations of pain expressions of same-race than other-race faces.

Neuropsychologia 2019 Apr 17. Epub 2019 Apr 17.

Peking-Tsinghua Center for Life Sciences, China. Electronic address:

Recent research has shown enhanced brain activity in responses to pain expression of same-race than other-race faces. However, due to the stimuli used in electctrophysiological (EEG) research (i.e. Read More

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http://dx.doi.org/10.1016/j.neuropsychologia.2019.04.008DOI Listing
April 2019
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Liver-derived Cell-free Nucleic Acids in Plasma: Biology and Applications in Liquid Biopsies.

J Hepatol 2019 Apr 17. Epub 2019 Apr 17.

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China; Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China; State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China. Electronic address:

There is much global research interest into the use of cell-free DNA (cfDNA) for liquid biopsies. cfDNA-based noninvasive prenatal testing (NIPT) for fetal chromosomal aneuploidies was the first success in using cfDNA technology to profoundly transform clinical practice, and has been rapidly adopted in dozens of countries and used by millions of pregnant women every year. Prompted by such developments, efforts to use cfDNA for other fields, especially for cancer detection and monitoring have been actively pursued in recent years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688278193025
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http://dx.doi.org/10.1016/j.jhep.2019.04.003DOI Listing
April 2019
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Effect of postpartum glucose tolerance results on subsequent weight retention in women with recent gestational diabetes: a retrospective cohort study.

Diabetes Res Clin Pract 2019 Apr 17. Epub 2019 Apr 17.

Women's College Research Institute, Women's College Hospital, Toronto, Canada; Institute of Health Policy, Management and Evaluation/Dalla Lana School of Public Health, University of Toronto, Toronto, Canada; Department of Medicine, University of Toronto, Toronto, Canada; Institute for Clinical Evaluative Sciences, Toronto, Canada; Sunnybrook Health Sciences Centre, Toronto, Canada. Electronic address:

Aims: Glucose tolerance normalizes postpartum in most women with gestational diabetes (GDM), which may provide false reassurance and decrease weight-reducing behaviours. We evaluated whether awareness of normal postpartum glucose tolerance was associated with higher weight retention than being unaware of glucose tolerance.

Methods: This cohort study of women with GDM collected survey data during pregnancy and in the first and second postpartum year. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.016DOI Listing

What is the role of peptide fragments of collagen I and IV in health and disease?

Life Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA. Electronic address:

Collagen is the most abundant protein in mammalian systems; it can be found in organs such as bones, the liver, kidney, heart, teeth, and skin. Collagen provides the necessary structural framework for tissues in which it is found. However, if there are any alterations in the delicate balance of collagen types in the extracellular matrix (ECM), then problems arise. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193030
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http://dx.doi.org/10.1016/j.lfs.2019.04.042DOI Listing
April 2019
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NPC1-deficient neurons are selectively vulnerable for statin treatment.

Neuropharmacology 2019 Apr 17. Epub 2019 Apr 17.

Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin und Berlin Institute of Health; Institut für Integrative Neuroanatomie, Klinische Zell- und Neurobiologie, CC2, Charité, 10117, Berlin, Germany.

Niemann Pick C (NPC) is a fatal hereditary neurovisceral disorder associated with a progressive loss of neurons of unknown mechanism. The disease is caused by mutation in either of two genes, termed npc1 and npc2, accounting for ∼95% and ∼5% of patients, respectively. Recent data suggest a cell-autonomous cause for neuronal cell death. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.04.012DOI Listing

Bio-assay: The best alternative for conventional methods in detection of epidermal growth factor.

Int J Biol Macromol 2019 Apr 17. Epub 2019 Apr 17.

Nanotechnology Research Center, Uremia University, Uremia, Iran.

Growth factors are necessary for proper and efficient wound closure and tissue regeneration. Epidermal growth factor (EGF) is one of the key signaling molecules in stimulating epithelial cell motility, making it a required factor for re-epithelialization. Increased EGF expression is likely to be a strong prognostic and predictive feature in multiple tumor types and determination of EGF may product remarkable diagnosis benefits. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130193085
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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.121DOI Listing
April 2019
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Hyaluronic acid - dihydroartemisinin conjugate: Synthesis, characterization and in vitro evaluation in lung cancer cells.

Int J Biol Macromol 2019 Apr 17. Epub 2019 Apr 17.

Product Development Cell-II, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India. Electronic address:

In recent years, a great deal of attention has been given towards re-purposing and re-innovating the potential drugs. In this regard, dihydroartemisinin (DHA) has been reported to demonstrate anti-proliferative effects on various cancerous cells viz. breast, liver and lung. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.124DOI Listing

Influence Of Age, Sex And Generation On Physician Payments And Clinical Activity In Ontario, Canada: An Age-Period-Cohort Analysis.

Am J Ophthalmol 2019 Apr 17. Epub 2019 Apr 17.

Department of Ophthalmology and Visual Sciences, University of Toronto, 340 College Street, Suite 400, Toronto, Ontario, Canada M5T 3A9; Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario, Canada M5T 3M7.

Purpose: To compare the effect of age, sex and generation on physician practice patterns in Ontario, Canada.

Design: Retrospective cohort study.

Methods: Physician and patient data from 1992-2013 were used to calculate yearly number of physicians, distinct patients seen, patient visits, government payments, physician age, sex, specialty and year of birth. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.04.006DOI Listing

Recent advances in 3D printing: vascular network for tissue and organ regeneration.

Transl Res 2019 Apr 5. Epub 2019 Apr 5.

Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC; Department of Electrical and Computer Engineering, The George Washington University, Washington, DC; Department of Biomedical Engineering, The George Washington University, Washington, DC; Department of Medicine, The George Washington University Medical Center, Washington, DC. Electronic address:

Over the past years, the fabrication of adequate vascular networks has remained the main challenge in engineering tissues due to technical difficulties, while the ultimate objective of tissue engineering is to create fully functional and sustainable organs and tissues to transplant in the human body. There have been a number of studies performed to overcome this limitation, and as a result, 3D printing has become an emerging technique to serve in a variety of applications in constructing vascular networks within tissues and organs. 3D printing incorporated technical approaches allow researchers to fabricate complex and systematic architecture of vascular networks and offer various selections for fabrication materials and printing techniques. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19315244193007
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http://dx.doi.org/10.1016/j.trsl.2019.04.002DOI Listing
April 2019
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Repressive role of stabilized HIF1α expression on TGFβ-induced extracellular matrix production in lung cancer cells.

Cancer Sci 2019 Apr 20. Epub 2019 Apr 20.

Department of Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Activation of transforming growth factor β (TGFβ) combined with persistent hypoxia are often affecting the tumor microenvironment. Disruption of cadherin/catenin complexes induced by these stimulations yields aberrant extracellular matrix (ECM) production, characteristics of an epithelial-mesenchymal transition (EMT). Hypoxia-inducible factors (HIFs), the hallmark of the response to hypoxia, play differential roles during development of diseases. Read More

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http://dx.doi.org/10.1111/cas.14027DOI Listing

Sensitivity to amplitude envelope rise time in infancy and vocabulary development at three years: A significant relationship.

Dev Sci 2019 Apr 20:e12836. Epub 2019 Apr 20.

The MARCS Institute for Brain, Behaviour and Development, Western Sydney University, Penrith, Australia.

Here we report, for the first time, a relationship between sensitivity to amplitude envelope rise time in infants and their later vocabulary development. Recent research in auditory neuroscience has revealed that amplitude envelope rise time plays a mechanistic role in speech encoding. Accordingly, individual differences in infant discrimination of amplitude envelope rise times could be expected to relate to individual differences in language acquisition. Read More

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http://dx.doi.org/10.1111/desc.12836DOI Listing

Determine safety of outpatient chemotherapy and autotransplants using refrigerated, non-frozen grafts in persons with multiple sclerosis.

Clin Transplant 2019 Apr 20:e13567. Epub 2019 Apr 20.

Centro de Hematología y Medicina Interna de Puebla, Puebla, México.

Persons with multiple sclerosis (MS) are sometimes treated with intermediate- or high-dose chemotherapy and an autotransplant (1, 2). More than 1000 autotransplants are reported with MS (2-6) but use of autotransplants may be substantially more common as many cases are not reported. Recent data from a small randomized trial of less-intensive chemotherapy reported better outcomes with this approach compared with disease-modifying therapy in persons with advanced relapsing-remitting MS (7). Read More

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http://dx.doi.org/10.1111/ctr.13567DOI Listing

A Realistic Review of the Drug-Injury Relief System in Taiwan: Challenges, Lessons, and Achievements.

Clin Pharmacol Ther 2019 Apr 20. Epub 2019 Apr 20.

Taiwan Drug Relief Foundation, Taipei, Taiwan.

The drug injury relief system in Taiwan was implemented 20 years ago, with the goal of providing timely relief for drug injuries incurred by the proper use of legal drugs. This system utilizes a non-litigation expert review process to evaluate drug injury relief applications, and 2,732 applications have been reviewed from 1999 to 2016. Of these, 1,572 applications received relief payments, an approval rate of 58%. Read More

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http://dx.doi.org/10.1002/cpt.1474DOI Listing

The evolution of our understanding and treatment of eating disorders over the past 50 years.

Authors:
Andrea Marks

J Clin Psychol 2019 Apr 20. Epub 2019 Apr 20.

Department of Pediatrics, The Icahn School of Medicine at Mount Sinai, New York, NY.

Although historical descriptions date back to the Hellenistic era, and Gull's naming of anorexia nervosa as a medical disorder to the late 19th century, it is only in the past 50 years that eating disorders have become widely recognized as the prevalent, potentially fatal, complex, and confounding biopsychosocial illnesses we confront today. This paper reviews the considerable advancements in our knowledge of eating disorders during three time periods: the "early years" of the 1960s and 1970s; the "middle years" of the 1980s and 1990s; and the 21st century to date. The recent Diagnostic and Statistical Manual of Mental Disorders, 5th Edition describes six major feeding and eating disorders. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jclp.22782
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http://dx.doi.org/10.1002/jclp.22782DOI Listing
April 2019
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The plant translatome surveyed by ribosome profiling.

Plant Cell Physiol 2019 Apr 20. Epub 2019 Apr 20.

RNA Systems Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan.

Although transcriptome changes have long been recognized as a mechanism to induce tentative substitution of expressed genes in diverse biological processes in plants, the regulation of translation-the final step of the central dogma of molecular biology-emerged as an alternative and prominent layer in defining the output of genes. Despite these demands, the genome-wide analysis of protein synthesis has posed technical challenges, resulting in the plant translatome being poorly understood. The development of ribosome profiling promises to address the hidden aspects of translation, and its application to plants is revolutionizing our knowledge of the translatome. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/pcp/pcz059DOI Listing
April 2019
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Improved methods for estimating abundance and related demographic parameters from mark-resight data.

Biometrics 2019 Apr 20. Epub 2019 Apr 20.

New Zealand Department of Conservation, Wellington, New Zealand.

Over the past decade there has been much methodological development for the estimation of abundance and related demographic parameters using so-called "mark-resight" data. Often viewed as a less invasive and less expensive alternative to conventional mark-recapture, mark-resight methods jointly model marked individual encounters and counts of unmarked individuals, and recent extensions accommodate common challenges associated with imperfect detection. When these challenges include both individual detection heterogeneity and an unknown marked sample size, we demonstrate several deficiencies associated with the most widely used mark-resight models currently implemented in the popular capture-recapture freeware Program MARK. Read More

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http://dx.doi.org/10.1111/biom.13058DOI Listing

Emerging Infectious Diseases and Antimicrobial Resistance (EIDAR).

Mil Med 2019 Apr 20. Epub 2019 Apr 20.

University of Nebraska Medical Center College of Public Health, 984355 Medical Center, Omaha, NB 68198.

Introduction: The Infectious Disease Clinical Research Program's (IDCRP) Emerging Infectious Diseases and Antimicrobial Resistance (EIDAR) Research Area is a Department of Defense (DoD) clinical research capability that is responsive and adaptive to emerging infectious disease (EID) threats to US military readiness. Among active-duty and other Military Health System (MHS) beneficiaries, EIDAR research is largely focused on evaluating the incidence, risk factors, and acute- and long-term health effects of military-relevant EIDs, especially those caused by high-consequence pathogens or are responsible for outbreaks among US military populations. The EIDAR efforts also address Force Health Protection concerns associated with antimicrobial resistance and antimicrobial stewardship practices within the MHS. Read More

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http://dx.doi.org/10.1093/milmed/usz081DOI Listing

Colonization of the Human Nose and Interaction with Other Microbiome Members.

Microbiol Spectr 2019 Mar;7(2)

University of Tübingen, Interfaculty Institute for Microbiology and Infection Medicine Tübingen, Infection Biology Unit, 72076 Tübingen, Germany.

is usually regarded as a bacterial pathogen due to its ability to cause multiple types of invasive infections. Nevertheless, colonizes about 30% of the human population asymptomatically in the nares, either transiently or persistently, and can therefore be regarded a human commensal as well, although carriage increases the risk of infection. Whereas many facets of the infection processes have been studied intensively, little is known about the commensal lifestyle of . Read More

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http://www.asmscience.org/content/journal/microbiolspec/10.1
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http://dx.doi.org/10.1128/microbiolspec.GPP3-0029-2018DOI Listing
March 2019
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Fulvestrant in the treatment of hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer: A review.

Cancer Med 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgery in Breast Cancer, Fudan University Shanghai Cancer Center, Shanghai, China.

Nearly 75% of breast cancers are hormone receptor-positive (HR+) and human epidermal growth factor receptor type 2-negative (HER2-), making endocrine therapy the mainstay of treatment for HR+ and HER2- combination. Although endocrine therapy, such as therapy with fulvestrant, is widely used in the clinic, endocrine resistance (primary or secondary) is inevitable and poses a serious clinical concern. However, the therapeutic landscape of HR+/HER2- breast cancer is rapidly changing and evolving. Read More

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http://dx.doi.org/10.1002/cam4.2095DOI Listing

Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population.

CNS Neurosci Ther 2019 Apr 19. Epub 2019 Apr 19.

Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

Aims: Recent evidence suggests that the opioid system is implicated in the pathophysiology of alcohol use disorder (AUD). We aimed to examine the genetic influence of opioid receptors on susceptibility to AUD and its clinical and psychological characteristics including harmful drinking behavior and various aspects of impulsivity in AUD patients.

Methods: Three μ-opioid receptor gene (OPRM1) variants and two κ-opioid receptor gene (OPRK1) variants were examined in 314 male patients with AUD and 324 male controls. Read More

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http://dx.doi.org/10.1111/cns.13138DOI Listing

Priority approaches of occupational safety and health activities for preventing low back pain among caregivers.

J Occup Health 2019 Apr 19. Epub 2019 Apr 19.

National Institute of Occupational Safety and Health, Kawasaki, Japan.

Objectives: The incidence of occupational low back pain (LBP) is high among caregivers. The use of care equipment and training about care methods could prevent LBP among caregivers. However, in care facilities in Japan, these measures are not adequately employed. Read More

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http://doi.wiley.com/10.1002/1348-9585.12055
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http://dx.doi.org/10.1002/1348-9585.12055DOI Listing
April 2019
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Brittle diabetes revisited: a description of erratic and difficult-to-control diabetes in an elderly woman with Type 1 diabetes.

Diabet Med 2019 Apr 19. Epub 2019 Apr 19.

Centre for Diabetes, Endocrinology and Metabolism, Galway University Hospitals and 2Discipline of Medicine, NUI Galway, Galway, Ireland.

Background: 'Brittle diabetes' is frequently attributed to psychological stressors causing insulin omission in young women with Type 1 diabetes. It has received little attention in the recent medical literature.

Case Report: We report the case of an 87-year-old woman who had recurrent episodes of unexplained diabetic ketoacidosis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/dme.13972
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http://dx.doi.org/10.1111/dme.13972DOI Listing
April 2019
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The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis: Basic science and new insights based on gene expression.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Endometriosis is a frequent and chronic illness in young women which could be defined by the existence of endometrial stroma and glands outside of the normal site of the lining of the uterus. It has painful symptoms. The advanced stage of endometriosis may lead to gynecological malignancies, such as ovarian cancer, and other complications, including infertility. Read More

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http://dx.doi.org/10.1002/jcp.28666DOI Listing

Drug delivery systems designed to overcome antimicrobial resistance.

Med Res Rev 2019 Apr 19. Epub 2019 Apr 19.

Université de Picardie Jules Verne, AGIR: Agents Infectieux, Résistance et Chimiothérapie, Amiens, France.

Antimicrobial resistance has emerged as a huge challenge to the effective treatment of infectious diseases. Aside from a modest number of novel anti-infective agents, very few new classes of antibiotics have been successfully developed for therapeutic use. Despite the research efforts of numerous scientists, the fight against antimicrobial (ATB) resistance has been a longstanding continued effort, as pathogens rapidly adapt and evolve through various strategies, to escape the action of ATBs. Read More

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http://dx.doi.org/10.1002/med.21588DOI Listing

In silico markers: an evolutionary and statistical approach to select informative genes of human breast cancer subtypes.

Genes Genomics 2019 Apr 19. Epub 2019 Apr 19.

Department of Informatics, University of Evora, 7004-516, Evora, Portugal.

Background: Recent advancement in bioinformatics offers the ability to identify informative genes from high dimensional gene expression data. Selection of informative genes from these large datasets has emerged as an issue of major concern among researchers.

Objective: Gene functionality and regulatory mechanisms can be understood through the analysis of these gene expression data. Read More

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http://dx.doi.org/10.1007/s13258-019-00816-8DOI Listing

Potential role of lncRNA-TSIX, miR-548-a-3p, and SOGA1 mRNA in the diagnosis of hepatocellular carcinoma.

Mol Biol Rep 2019 Apr 19. Epub 2019 Apr 19.

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, P.O. Box 11381, Egypt.

Recent trends are moving towards the use of the circulating transcriptome as a potential diagnostic and therapeutic tool for hepatocellular carcinoma (HCC). The aim of this study is to identify circulatory RNA based biomarker panel, in addition to their relationship to the outcome in HCC. First, utilizing bioinformatics tools, we selected an HCC-specific RNA-based biomarker panel that depended on the integration of suppressor of glucose autophagy-associated (SOGA1) gene expression with the chosen panel of epigenetic regulators of this gene [long non-coding RNA antisense for X-inactive-specific transcript (lncRNA-TSIX) and microRNA-548-a-3p (miR-548-a-3p)]. Read More

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http://link.springer.com/10.1007/s11033-019-04810-x
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http://dx.doi.org/10.1007/s11033-019-04810-xDOI Listing
April 2019
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Trans-synaptic Neural Circuit-Tracing with Neurotropic Viruses.

Neurosci Bull 2019 Apr 19. Epub 2019 Apr 19.

Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.

A central objective in deciphering the nervous system in health and disease is to define the connections of neurons. The propensity of neurotropic viruses to spread among synaptically-linked neurons makes them ideal for mapping neural circuits. So far, several classes of viral neuronal tracers have become available and provide a powerful toolbox for delineating neural networks. Read More

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http://dx.doi.org/10.1007/s12264-019-00374-9DOI Listing

Ultrasound detection and closure of contralateral patent processus vaginalis in pediatric patients with unilateral inguinal hernia and hydrocele: a longitudinal study to prove efficacy in avoiding contralateral hernia development.

Authors:
P K F Yip

Hernia 2019 Apr 19. Epub 2019 Apr 19.

Minimally Invasive Paediatric Surgery Centre, Room 1105, 11/F, Nathan Road, Mong Kok, Kowloon, Hong Kong.

Background: Open herniotomy has been the gold standard of pediatric hernia treatment with the advantages of simplicity in surgical technique, fast post operative recovery, and minimal recurrence rate, but its inability to prevent hernia development from a contralateral patent processus vaginalis (PPV) after a unilateral herniotomy is its major drawback. By contrast, laparoscopic hernia repair has the advantage of contralateral internal ring inspection, and, therefore, has become popular in recent years, although open herniotomy is still the favorable surgical technique among many surgeons. A simple and reliable tool to detect contralateral PPV will be valuable to surgeons who practice conventional open hernia surgery on children, although ultrasound has been applied for this purpose, but there is no long-term data to support such application. Read More

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http://link.springer.com/10.1007/s10029-019-01951-7
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http://dx.doi.org/10.1007/s10029-019-01951-7DOI Listing
April 2019
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Spermine and gene methylation: a mechanism of lifespan extension induced by polyamine-rich diet.

Authors:
Kuniyasu Soda

Amino Acids 2019 Apr 19. Epub 2019 Apr 19.

Cardiovascular Research Institute, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama-City, Saitama, Japan.

The polyamines spermidine and spermine are synthesized in almost all organisms and are also contained in food. Polyamine synthesis decreases with aging, but no significant decrease in polyamine concentrations were found in organs, tissues, and blood of adult animals and humans. We found that healthy dietary patterns were associated with a preference for polyamine-rich foods, and first reported that increased polyamine intake extended the lifespan of mice and decreased the incidence of colon cancer induced by repeated administration of moderate amounts of a carcinogen. Read More

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http://dx.doi.org/10.1007/s00726-019-02733-2DOI Listing
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