261 results match your criteria Recent Patents on Drug Delivery and Formulation [Journal]


Scientific Papers and Patents on Substances with Unproven Effects.

Authors:
Sergei V Jargin

Recent Pat Drug Deliv Formul 2019 Mar 7. Epub 2019 Mar 7.

Peoples' Friendship University of Russia, Clementovski per 6-82, 115184 Moscow. Russian Federation.

It is evident from reviewing of scientific literature that the quality of argumentation in some areas of medical research has deteriorated during last decades. Publication of series of questionable reliability have been continued without making references to the published criticism; examples are discussed in this review. Another tendency is that drugs without proven efficiency are advertised, corresponding products patented and marketed as evidence-based medications. Read More

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http://www.eurekaselect.com/170543/article
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http://dx.doi.org/10.2174/1872211313666190307162041DOI Listing
March 2019
6 Reads

Pharmaceutical Cocrystal: A Novel Approach to Tailor the Biopharmaceutical Properties of a Poorly Water Soluble Drug.

Recent Pat Drug Deliv Formul 2019 Mar 6. Epub 2019 Mar 6.

Department Of Pharmaceutics and Pharmacokinetics, Division, CSIR-Central Drug Research Institute, Lucknow. India.

Aim And Background: The present study reports the formation of a cocrystal of candesartan with the coformer methyl paraben,its characterization and determination of its bioavailability.Candesartan is a poorly water soluble drug having an anti-hypertensive activity. The recent patents on the cocrystals of the drugs Progesterone (US9982007B2), Epalrestat (EP2326632B1), Gefitinib (WO2015170345A1), Valsartan(CN102702118B) for enhancement of solubility helped in selection of the drug for this work. Read More

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http://dx.doi.org/10.2174/1872211313666190306160116DOI Listing
March 2019
2 Reads

Synthesis and characterization of Valcyclovir HCl hybrid solid lipid nanoparticles by using Natural oils.

Recent Pat Drug Deliv Formul 2019 Mar 4. Epub 2019 Mar 4.

Rayat-Bahra Institute of Pharmacy, Rayat-Bahra University,Punjab. India.

Background: The Jojoba Simmondsia Chinensis oil is used as one of the main ingredients which have an antioxidant, moisturizing and stabilizing activity. Likewise, grape seed (Vitis vinifera) oil is also used in this preparation which also has some remarkable medicinal properties such as antioxidant, astringent and as a moisturizer. The Valacyclovir solid lipid nanoparticles (SLN) were prepared in combination. Read More

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http://dx.doi.org/10.2174/1872211313666190304142129DOI Listing
March 2019
1 Read

Bilayer Tablet Based Chronotherapeutics in the Management of Nocturnal Asthma: An Overview.

Recent Pat Drug Deliv Formul 2019 Feb 27. Epub 2019 Feb 27.

Abbott Healthcare Private Limited, Baddi (Himachal Pradesh), . India.

Background And Aim: Asthma is a common ailment having larger circadian difference. The nocturnal asthma (NA) is inconstant exacerbation of asthma condition related to the rises in warning sign at night and there is need for treatment, air route alertness, and/or falling of lung role. These symptoms are linked to sleep or known as circadian events. Read More

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http://dx.doi.org/10.2174/1872211313666190227204127DOI Listing
February 2019
1 Read

Progress in Drug and Formulation development for Chemoprevention of Oral Squamous Cell Carcinoma: A review.

Recent Pat Drug Deliv Formul 2019 Feb 22. Epub 2019 Feb 22.

Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh 786004, Assam. India.

Background: Cancer is a life-threatening global problem with high incidence rates. Prioritizing the prevention of cancer, chemopreventive agents have drawn much attention from the researchers.

Objective: This review focuses on discussion of the progress in the development of chemopreventive agents and formulations related to the prevention of oral cancer. Read More

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http://dx.doi.org/10.2174/1872211313666190222182824DOI Listing
February 2019
2 Reads

Nanocarriers for vaginal drug delivery.

Recent Pat Drug Deliv Formul 2019 Feb 15. Epub 2019 Feb 15.

Laboratory of Nanomedicine, Institute of Life Sciences, Nalco Square, Bhubaneswar -751023, Odisha. India.

Background: Vaginal drug delivery approach represents one of the imperative strategies for local and systemic delivery of drugs. The peculiar dense vascular networks, mucus permeability, range of physiological characteristics of the vaginal cavity have been exploited for therapeutic benefit. Furthermore, the vaginal drug delivery has been curtailed due to the influence of different physiological factors like acidic pH, constant cervical secretion, microflora, cyclic changes during periods along with turnover of mucus of varying thickness. Read More

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http://dx.doi.org/10.2174/1872211313666190215141507DOI Listing
February 2019
1 Read

A review on enteric coated pellets composed of core pellets prepared by extrusion-spheronization.

Recent Pat Drug Deliv Formul 2019 Feb 11. Epub 2019 Feb 11.

Department of Pharmacy, Anand Pharmacy College, Anand, Gujarat. India.

Enteric coated dosage form bypasses the stomach and releases the drug into the small intestine. Advantages of enteric coated pellets in comparison with enteric coated tablets are a) Pellets provide rapid onset of action and faster drug release due to the smaller size than tablets and b) Pellets exhibits less residence time of acid-labile drugs in the stomach compared to tablets. Dosage form coat can be damaged by longer resistance time in the stomach. Read More

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http://dx.doi.org/10.2174/1872211313666190212115139DOI Listing
February 2019

Design, Development and In vitro/Ex vivo Evaluation of Mucoadhesive Buccal Film of Benzydamine Hydrochloride for the Effective Treatment of Aphthous Stomatitis.

Recent Pat Drug Deliv Formul 2018 ;12(4):277-294

Department of Pharmaceutics, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial (ASBASJSM) College of Pharmacy, Bela, Ropar, Punjab 140111, India

Background: During the recent two decades, the development of mucoadhesive drug delivery system has been gained tremendous importance to cure many recurrent diseases of the oral cavity. The drug delivery through the buccal route is quite challenging due to limited absorption area, movements of the target region and regular flow of saliva lead to the sub-therapeutic drug level in the buccal region.

Objective: The aim is to develop unidirectional release mucoadhesive buccal film for the mucosal delivery of Benzydamine Hydrochloride (WO2016126217Al, EP0812193B1) and evaluate the effects of a different grade of HPMC polymer (US5980942A) with the presumption to prolong the residence time and therapeutic effectiveness at the target site. Read More

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http://dx.doi.org/10.2174/1872211313666190128151038DOI Listing
January 2018
6 Reads

Nanocapsules for Drug Delivery: An Updated Review of the Last Decade.

Recent Pat Drug Deliv Formul 2018 ;12(4):252-266

Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Sihhiye-Ankara, Turkey.

Background: For the past few decades, there has been considerable research interest in drug delivery strategies using nanoparticulate systems as carriers for a wide range of active pharmaceutical ingredients.

Objective: It is known that nanoparticulate drug delivery systems comprise a wide variety of dosage forms including nanospheres, micelles, solid lipid nanoparticles, nanoliposomes, dendrimers, magnetic nanoparticles, and nanocapsules.

Methods: This review describes nanocapsule preparation techniques and their applications for the treatment of several diseases using patents and examples from the literature. Read More

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http://dx.doi.org/10.2174/1872211313666190123153711DOI Listing
January 2018
10 Reads

Review of Recent Patents and Developments in Skeletal Muscle Regeneration.

Recent Pat Drug Deliv Formul 2018 ;12(4):238-251

College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

Skeletal muscle is a highly-specialized tissue that is capable of contractile function and able to withstand and adapt to daily mechanical and physiological stress. Musculoskeletal disorders, including muscular dystrophies, result in chronic pain and disability, reduced quality of life, burden on family, and increased healthcare costs. Although several mechanisms have been identified for muscle injury and regeneration, mechanisms of these diseases are poorly understood, and targeted and effective pharmacologic treatment(s) are not available. Read More

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http://dx.doi.org/10.2174/1872211313666190102102005DOI Listing
January 2018
2 Reads

Montelukast Sodium Formulation Containing Green Tea Extract to Reduce the Oxidative Stress in Guinea Pig Model of Chronic Allergic Asthma.

Recent Pat Drug Deliv Formul 2018 ;12(4):267-276

Department of Pharmaceutics, ITS College of Pharmacy, NH-34, Ghaziabad-201206, India.

Aim And Background: The rationale of this study is that, treatment of asthmatic Guinea pig with combined administration of Montelukast sodium and Green Tea Extract (GTE) as a single capsule will mitigate the inflammatory injury in the airways and weaken the asthmatic response. Recent patents for the treatment of asthma researched a polyphenolic alternatives for antiasthmatic combination therapy, especially for those patients who remains unresponsive or poorly responsive for current asthma therapy (US7232585B2). Synergistic activity of green tea polyphenols and therapeutic, prophylatic agents are also reported in some recent patents (US20120172423A1, US20150320696A1). Read More

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http://www.eurekaselect.com/168253/article
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http://dx.doi.org/10.2174/1872211313666181211123903DOI Listing
January 2018
3 Reads

Mesoporous Silica Nanoparticles: A Versatile Platform for Biomedical Applications.

Recent Pat Drug Deliv Formul 2018 ;12(4):228-237

Laboratory of Nanomedicine, Institute of Life Sciences, Nalco Square, Bhubaneswar - 751023, Odisha, India.

Background: Nanotechnology-based drug delivery approach has emerged as a promising field, where different kinds of formulations are developed for therapeutic applications. Inflowing of nanomedicine developed through various biomaterials appears to be a game changer in the domain of pharmaceutical and biotechnological industries. Nanomedicines propose to overcome the major constraints of conventional medicine of low solubility and stability, non-adequate pharmacokinetic profiles and side effects. Read More

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http://dx.doi.org/10.2174/1872211313666181203152859DOI Listing
January 2018
2 Reads

The Unprecedented Role of Gold Nonmaterial in Diabetes Management.

Recent Pat Drug Deliv Formul 2018 Nov 14. Epub 2018 Nov 14.

Analytical Research and Development Division, Indian Pharmacopoeia Commission, Ministry of Health & Family Welfare Govt. of India. Sector-23, Raj Nagar, Ghaziabad-201 002 . India.

Background: Gold nanoparticles possess unique mechanical, chemical, photo-optical and biological properties and have been an interesting field of research and development in life sciences. Research efforts in this area have resulted in innovative nanodevices and nanostructures useful in the diagnostics, biosensing, therapeutics, and targeted drug delivery.

Objective: In this review, the unique potential aspects of gold nanoparticles/ nanoformulations/ or devices related to diabetes management have been discussed together with the recent patent on the gold nanoparticles / or developed for diabetes management. Read More

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http://www.eurekaselect.com/167382/article
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http://dx.doi.org/10.2174/1871526518666181114165352DOI Listing
November 2018
17 Reads

Self-Emulsifying Drug Delivery System of Simvastatin: Formulation Development, Optimization by Box- Behnken Design, and Single-Pass Intestinal Perfusion (SPIP) Studies.

Recent Pat Drug Deliv Formul 2018 ;12(3):199-211

I.T.S College of Pharmacy Muradnagar, Ghaziabad, Uttar Pradesh, India.

Purpose: The purpose of the study was formulation development, optimization and evaluation of a Self-Emulsifying Drug Delivery System (SEDDS) of Simvastatin (SIM) for improvement in dissolution and bioavailability of SIM. Solubility enhancement of Biopharmaceutical Classification System (BCS) Class-II drugs is a burning topic and attracting various publications and patents regarding different strategies employed for improvement of dissolution viz., USOO5340591A (Solid dispersion), US005472954A, US005646131A (complexation), USOO5858410A (Nanosuspensions), USOO5874029A (micronization) US2008. Read More

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http://www.eurekaselect.com/166517/article
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http://dx.doi.org/10.2174/1872211312666181022150435DOI Listing
March 2019
13 Reads

Role of Porous Carriers in the Biopharmaceutical Performance of Solid SMEDDS of Canagliflozin.

Recent Pat Drug Deliv Formul 2018 ;12(3):179-198

Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143005, India.

Objective: The aim of the present investigation entails the development of solid SMEDDS for improving the oral bioavailability of canagliflozin using porous carriers. The previous patent (WO2017046730A1) was based on enhanced solubility of canagliflozin through co-crystal formation.

Methods: Preconcentrates were prepared by employing Lauroglycol (80 mg), Tween 80 (300 mg) and Transcutol P (120 mg) and successfully adsorbed onto various hydrophilic and hydrophobic carriers. Read More

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http://www.eurekaselect.com/166008/article
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http://dx.doi.org/10.2174/1872211312666181008111354DOI Listing
March 2019
15 Reads

Antibacterial and Growth Inhibition Study of Struvite Urinary Stones Using Linn. Leaf Extract and its Biofabricated Silver Nanoparticles.

Recent Pat Drug Deliv Formul 2018 ;12(3):170-178

Department of Chemistry, School of Advanced Sciences, VIT University, Vellore-632014, India.

Background: Herbal drugs are gaining exponential scientific recognition due to their distinct advantages. In the last 2-3 decades, a gradual increase in worldwide patents on herbal nanoformulations has been noted to address the solubility and bioavailability issues of phytoceuticals. Struvite or ammonium magnesium phosphate hexahydrate (NH4MgPO4. Read More

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http://dx.doi.org/10.2174/1872211312666180723160624DOI Listing
March 2019
8 Reads

Clinical Application of Polysialylated Deoxyribonuclease and Erythropoietin.

Recent Pat Drug Deliv Formul 2018 ;12(3):212-222

Xenetic Biosciences, Incorporated, 99 Hayden Avenue, Lexington, MA 02421, United States.

Background: While protein therapeutics are invaluable in managing numerous diseases, many require frequent injections to maintain therapeutically effective concentrations, due to their short half-life in circulation. PolyXen™, a platform and patented technology employing biodegradable, non-immunogenic and hydrophilic Polysialic Acids (PSA) for drug delivery, is being utilized to overcome such limitations, thereby potentially enabling the clinical utility of a broad range of protein therapeutics. Here, we report the recent progress on two development candidates, polysialylated deoxyribonuclease I (PSA-DNase) and polysialylated erythropoietin (PSA-EPO). Read More

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http://www.eurekaselect.com/163851/article
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http://dx.doi.org/10.2174/1872211312666180717164758DOI Listing
March 2019
27 Reads

Preparation, Characterization and In Vivo Assessment of Repaglinide Nanosuspension for Oral Bioavailability Improvement.

Recent Pat Drug Deliv Formul 2018 ;12(3):162-169

Principal, H R Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur 425405, India.

Aims And Background: The objective of the study was to improve the bioavailability of poorly soluble repaglinide (RPG) by preparing nanosuspension with poloxamer 188 using high pressure homogenization (HPH). The recent patents on nanocrystals (US20150337006A1) facilitated selection of drug and polymer.

Methods: Suspensions containing dissimilar sized particles were prepared by ultrasonication and HPH. Read More

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http://dx.doi.org/10.2174/1872211312666180713105959DOI Listing
March 2019
3 Reads

Comparative Study on Photodynamic Activation of Ortho-Toluidine Blue and Methylene Blue Loaded Mesoporous Silica Nanoparticles Against Resistant Microorganisms.

Recent Pat Drug Deliv Formul 2018 ;12(3):154-161

Department of Pharmaceutics, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, Vile Parle (West), Maharashtra, India.

Aims And Background: The number of pathogenic microorganisms has been increasing over the years, and so as resistance of these microorganisms are developing against various antibiotics. Antimicrobial photodynamic therapy (aPDT), also called photodynamic inactivation, is emerging as a promising alternative to treatments based on conventional antibiotics. Recent patents on structured silver mesoporous silica nanoparticles having antimicrobial activity (WO2010/071831 A2), photosensitiser modified core-shell structure nanocomposites (CN 103536935(A)), and Chitosan-coated magnetic mesoporous silica nanoparticles (MSN) (CN 104785214(A)) helped in selecting method of synthesis of MSN and photosensitizers. Read More

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http://dx.doi.org/10.2174/1872211312666180627093316DOI Listing
March 2019
25 Reads

Orodispersible Films: A Systematic Patent Review.

Recent Pat Drug Deliv Formul 2018 ;12(2):110-120

School of Pharmacy & Technology Management, SVKM`s NMIMS, Shirpur, Maharashtra, India.

Background: Nowadays, Oral Film Technology (OFT) has gained much attention among all the oral drug delivery systems. Fast dissolving film, fast disintegrating film, and orodispersible film are some synonymous words for this dosage form. Without a need of liquid for administration, this dosage form dissolves in the mouth. Read More

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http://www.eurekaselect.com/161983/article
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http://dx.doi.org/10.2174/1872211312666180509100216DOI Listing
November 2018
28 Reads

Nanocarriers for the Effective Treatment of Cervical Cancer: Research Advancements and Patent Analysis.

Recent Pat Drug Deliv Formul 2018 ;12(2):93-109

Department of Pharmaceutics, Rajiv Academy for Pharmacy, P.O. Chhattikara, Mathura- 281001, Uttar Pradesh, India.

Background: Cervical cancer being the cancer of cervix is caused by an aberrant cell growth that acquires an ability to spread/ invade to other body parts. It has also been reported to be the second most common cause of death and cancer among women. Based on the severity of the disease, treatment aspects need to be explored more in order to overcome the limitations acquired by the conventional treatment. Read More

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http://dx.doi.org/10.2174/1872211312666180403102019DOI Listing
November 2018
11 Reads

An Overview on Various Approaches and Recent Patents on Gastroretentive Drug Delivery Systems.

Recent Pat Drug Deliv Formul 2018 ;12(2):84-92

Department of Pharmaceutical Sciences, M.D. University, Rohtak 124001, India.

Background: Drugs having absorption window in the stomach or upper small intestine have restricted bioavailability with conventional dosage forms. The gastric residence time of these dosage forms is usually short and they do not show drug release for prolonged period of time.

Objective: To avoid these problems and to enhance the bioavailability and gastric retention time of these drugs, controlled drug delivery systems with prolonged gastric retention time are currently being developed. Read More

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http://dx.doi.org/10.2174/1872211312666180308150218DOI Listing
November 2018
6 Reads

Development of Microemulsion Based Nabumetone Transdermal Delivery for Treatment of Arthritis.

Recent Pat Drug Deliv Formul 2018 ;12(2):130-149

Department of Pharmaceutics, MAEER`s Maharashtra Institute of Pharmacy, MIT Campus, Kothrud, Pune, (MS), 411038, India.

Background: Nabumetone is biopharmaceutics classification system (BCS) class II drug, widely used in the treatment of osteoarthritis and rheumatoid arthritis. The most frequently reported adverse reactions for the drug involve disturbance in gastrointestinal tract, diarrhea, dyspepsia and abdominal pain. Microemulgel has advantages of microemulsion for improving solubility for hydrophobic drug. Read More

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http://www.eurekaselect.com/160127/article
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http://dx.doi.org/10.2174/1872211312666180227091059DOI Listing
November 2018
16 Reads

Formulation, In-Vitro and Ex-Vivo Evaluation of Tretinoin Loaded Cubosomal Gel for the Treatment of Acne.

Recent Pat Drug Deliv Formul 2018 ;12(2):121-129

School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh 173 229, India.

Objective: The current work was attempted to formulate and evaluate the topical sustained release delivery systems called cubosomes containing Tretinoin for the acne treatment. The recent patents on various formulations of tretinoin (EP0408370A2) helped in selecting a new formulation and evaluation.

Methods: Tretinoin loaded cubosomes were prepared by bottom-up technique, using varying the concentration of lipid and surfactant and keeping the drug concentration constant, a total of nine formulations of tretinoin was developed. Read More

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http://dx.doi.org/10.2174/1872211312666180213121117DOI Listing
November 2018
12 Reads

Withdrawn: Novel Ternary Polymeric Blends for Controlled Release Matrices Containing Weakly Basic Model Drug.

Recent Pat Drug Deliv Formul 2018 01 23. Epub 2018 Jan 23.

Ahead of Print article withdrawn by publisher. Read More

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http://dx.doi.org/10.2174/1872211312666180123120021DOI Listing
January 2018
6 Reads

Crystalline Ethylene Oxide and Propylene Oxide Triblock Copolymer Solid Dispersion Enhance Solubility, Stability and Promoting Time- Controllable Release of Curcumin.

Recent Pat Drug Deliv Formul 2018 ;12(1):65-74

Laboratory of Biomaterials and Nanotechnology- UNISO. Sorocaba, SP, Brazil.

Aims And Background: The design and development of an effective medicine are, however, often faced with a number of challenges. One of them is the close relationship of drug's bioavailability with solubility, dissolution rate and permeability. The use of curcumin's (CUR) therapeutic potential is limited by its poor water solubility and low chemical stability. Read More

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http://www.eurekaselect.com/159171/article
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http://dx.doi.org/10.2174/1872211312666180118104920DOI Listing
October 2018
8 Reads

Editorial.

Authors:
Ryan F Donnelly

Recent Pat Drug Deliv Formul 2017 ;11(2):82

School of Pharmacy Queen's University Belfast Belfast. United Kingdom.

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http://dx.doi.org/10.2174/187221131102171220154834DOI Listing
January 2017
6 Reads

Patented and Approval Scenario of Nanopharmaceuticals with Relevancy to Biomedical Application, Manufacturing Procedure and Safety Aspects.

Recent Pat Drug Deliv Formul 2018 ;12(1):40-52

Department of Pharmacy, NIMS University, Shobha Nagar, Delhi highway, Jaipur, Rajasthan, India.

Background: Nanopharmaceutical is the field that arises gradually but many challenges are also still there. This review aims to identify these challenges and give the focus on their rectification.

Methods: In this paper, we memorize the safety issues, patented manufacturing procedure, applications and regulatory aspects of the nanopharmaceuticals by using the peer-reviewed research literatures. Read More

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http://www.eurekaselect.com/158842/article
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http://dx.doi.org/10.2174/1872211312666180105114644DOI Listing
October 2018
10 Reads

Aripiprazole-Loaded Polymeric Micelles: Fabrication, Optimization and Evaluation using Response Surface Method.

Recent Pat Drug Deliv Formul 2018 ;12(1):53-64

H.R. Patel Institute of Pharmaceutical Education and Research, Near Karwand Naka, Shirpur, Dist-Dhule, Maharashtra, India.

Aims And Background: The fundamental objective of current study was to encapsulate Aripiprazole (ARP) within Pluronic F127 micelles to improve its aqueous solubility. The recent patents on Aripiprazole (JP2013136621) and micelles (WO2016004369A1) facilitated selection of drug and polymer.

Materials And Methods: The drug-laden micelles were fabricated using thin-film hydration technique. Read More

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http://dx.doi.org/10.2174/1872211312666180105112430DOI Listing
October 2018
4 Reads

A New Approach to Enhance the Solubility of Famotidine Tablet by Using Naturally Isolated Pear Starch.

Recent Pat Drug Deliv Formul 2018 ;12(1):75-80

School of Pharmacy, BBD University, Lucknow, India.

Purpose: The solubility of drug is affected by various excipients present in formulation. In case of tablet formulation, the role of binders is very important for solubility of dosage form as well as drug. In this study, an attempt was made to improve the solubility and dissolution rate of a drug by the use of natural excipients. Read More

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http://dx.doi.org/10.2174/1872211312666180105113037DOI Listing
October 2018
19 Reads

Chronopharmacokinetic Evaluation of Budesonide Multiparticulate Systems.

Recent Pat Drug Deliv Formul 2017 ;11(3):221-229

Sri Padmavathi School of Pharmacy, Tiruchanur, Tirupati, IN-517503, India.

Background: Poor oral absorption of budesonide limits the design of its solid oral dosage form. With this context, multiparticulate pulsatile system of budesonide for chronotherapy of nocturnal asthma was aimed in this study.

Methods: Initially, solid dispersions of budesonide (BD) using sodium starch glycolate (SSG) and guar gum (GG) were developed and characterized. Read More

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http://dx.doi.org/10.2174/1872211312666171213113127DOI Listing
September 2018
7 Reads

Natural Product Formulations for the Prevention and Treatment of Alzheimer's disease: A Patent Review.

Recent Pat Drug Deliv Formul 2018 ;12(1):23-39

Department of Medical Physics and Biophysics, Medical University-Sofia, Sofia, Bulgaria.

Introduction: Although considerable efforts have been made to develop effective therapeutic agents for Alzheimer's Disease (AD), neither a consensus concerning the pathogenesis of the disease nor a successful therapy for its treatment is yet available. The natural product chemistry brings tremendous diversity and abundant resource for medical needs.

Objectives: The present review summarizes recent patents on natural extracts and derived drugs as agents for the prevention and treatment of AD. Read More

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http://dx.doi.org/10.2174/1872211312666171207152326DOI Listing
October 2018
7 Reads

Thymoquinone a Potential Therapeutic Molecule from the Plant Nigella sativa: Role of Colloidal Carriers in its Effective Delivery.

Recent Pat Drug Deliv Formul 2018 ;12(1):3-22

University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh, India.

Background: From the past few decades, remarkable awareness has laid on the use of herbal medicines in pharmaceutical research. Thymoquinone (TQ), the main chemical constituent of Nigella Sativa (NS) plant, has been extensively explored, and revealed an array of therapeutic benefits, in different in vitro, and in vivo conditions. This review provides brief outline of the diverse therapeutics actions of TQ, and NS, viz. Read More

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http://dx.doi.org/10.2174/1872211311666171129121128DOI Listing
October 2018
19 Reads

Furosemide - Soluplus® Solid Dispersion: Development and Characterization.

Recent Pat Drug Deliv Formul 2017 ;11(3):211-220

Department of Pharmaceutical Science and Technology, Birla Institute of Technology, Mesra, Ranchi, India.

Background: Recent patents reveal that Soluplus® has proved to be a promising excipient that modulates dissolution characteristics of many active pharmaceutical ingredients (WO2016161995A1, WO2016169534A1 and WO2016165676A1).

Objective: Current article investigates stable solid solution of furosemide with Soluplus® to enhance the dissolution properties of the drug.

Method: Drug to carrier ratios to prepare solid dispersion were selected based on the phase solubility study. Read More

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http://www.eurekaselect.com/157819/article
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http://dx.doi.org/10.2174/1872211311666171129120020DOI Listing
September 2018
19 Reads

Enhanced Both in vitro and in vivo Kinetics by SLNs Induced Transdermal System of Furosemide: A Novel Approach.

Recent Pat Drug Deliv Formul 2017 ;11(3):187-197

Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalaym (Women's University), Tirupati 517 502, India.

Background: Furosemide is a potent diuretic agent used to treat pulmonary arterial hypertension. Variable dosage regimen and poor pharmacokinetic parameters have led to the development of transdermal drug delivery system.

Objective: Patent on suitability of multi-lamellar structures for excellent transdermal delivery (US0367475A1) has encouraged us to formulate the solid lipid nanoparticles (SLNs) induced transdermal systems of furosemide to enhance the kinetic properties without incorporating any penetration enhancer and rate limiting polymers. Read More

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http://dx.doi.org/10.2174/1872211311666171129115441DOI Listing
September 2018
10 Reads

Phytochemicals Formulated As Nanoparticles: Inventions, Recent Patents and Future Prospects.

Recent Pat Drug Deliv Formul 2017 ;11(3):173-186

Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, India.

Background: The quest to improve the therapeutic effectiveness of herbal drugs has driven the pharmaceutical research towards the development of herbal nanoparticles.

Objective: Till date, various approaches have been adopted for the design of herbal nanoparticles.

Methods: We carried out an organized search of bibliographic databases consisting of an ample number of published abstracts and research articles using a focused review questionaries and insertion/ omission criteria. Read More

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http://dx.doi.org/10.2174/1872211311666171120102531DOI Listing
September 2018
7 Reads

Development of Floating Delivery for Solid Self Micro-Emulsifying Drug Delivery System of Prochlorperazine Maleate.

Recent Pat Drug Deliv Formul 2017 ;11(3):198-210

MAEER's Maharashtra Institute of Pharmacy, S.No 124, MIT Campus, Kothrud, Pune-411038, India, Maharashtra, Pune, India.

Background: Prochlorperazine maleate (PCM) is a phenothiazine antipsychotic used in the treatment of nausea, vomiting and vertigo. It is BCS class II drug with only 12.5% bioavailability. Read More

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http://www.eurekaselect.com/156920/article
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http://dx.doi.org/10.2174/1872211311666171108112349DOI Listing
September 2018
31 Reads

Recent Patent Advances for Neurodegenerative Disorders and its Treatment.

Recent Pat Drug Deliv Formul 2017 ;11(3):158-172

Faculty of Pharmacy, DIT University, Uttrakhand 248009, India.

Background: Neurodegenerative disorders are among the most common challenging diseases that affect the population with extreme medical and financial burdens. Widely seen neurodegeneration affects population of all ages, as it progresses with age, affecting a large proportion of elderly population including patients, caregivers, and immensely increasing the financial load of the country. These diseases have a very complex nature that frequently results from combined genetic, environmental and pathological factors. Read More

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http://dx.doi.org/10.2174/1872211311666171010123958DOI Listing
September 2018
7 Reads

A Review of Patents on Therapeutic Potential and Delivery of Hydroge n Sulfide.

Recent Pat Drug Deliv Formul 2017 ;11(2):114-123

Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University 68178, Omaha, Nebraska, NE. United States.

Background: Hydrogen sulfide (H2S) is a colorless gas with a characteristic smell of rotten eggs. Once only thought of as a toxic gas, evidence now shows that H2S plays major roles in pathological and physiological activities. These roles are being utilized to treat diseases and disorders ranging from hypertension, inflammation, edema, cardiovascular issues, chronic pain, cancer, and many more. Read More

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http://dx.doi.org/10.2174/1872211311666170911160914DOI Listing
August 2018
21 Reads

Editorial.

Authors:
Ryan F Donnelly

Recent Pat Drug Deliv Formul 2017 ;11(1)

School of Pharmacy,Queen's University Belfast, United Kingdom.

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http://dx.doi.org/10.2174/187221131101170706113041DOI Listing
January 2017
5 Reads

Bronchoscopy in Children for Research with Questionable Indications: An Overview of Russian Patents and Publications.

Authors:
Sergei V Jargin

Recent Pat Drug Deliv Formul 2017 ;11(2):83-88

Peoples' Friendship University of Russia, Clementovski per 6-82, 115184 Moscow. Russian Federation.

Background: This review is a continuation of preceding papers on invasive methods applied for diagnostics or drug delivery with questionable clinical indications and/or research purposes. It aims to serve as a reminder that the risk-to-benefit ratio should be kept as low as possible.

Methods: Review of literature and Russian patents; author's observations since 1983. Read More

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http://dx.doi.org/10.2174/1872211311666170426093914DOI Listing
August 2018
18 Reads

Formulation, Characterization and In-vitro Evaluation of Fast Dissolv ing Tablets Containing Gliclazide Hydrotropic Solid Dispersions.

Recent Pat Drug Deliv Formul 2017 ;11(2):147-154

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, New South Wales. Australia.

Background: Low aqueous solubility is a major problem faced with new drug molecules. The purpose of this research was to provide a fast dissolving oral dosage form of Gliclazide (GLZ) using the concept of mixed hydrotropy. The recent patents on Adenosine (US20140107059A1), Growth hormone releasing factor peptide (EP0984788A1) and Paclitaxel (WO2002030466A2) helped in selecting the hydrotropes. Read More

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http://dx.doi.org/10.2174/1872211311666170427100213DOI Listing
August 2018
45 Reads

Magnetic Nanoparticles: A Review on Stratagems of Fabrication an d its Biomedical Applications.

Recent Pat Drug Deliv Formul 2017 ;11(2):101-113

School of Medical & Allied Sciences, Galgotias University, U.P. 201308, Greater Noida. India.

Background: The aim of this review is to provide an insight to the underlying biomedical applications of magnetic nanoparticles (MNPs).

Methods: The most specific characteristic of MNPs is their response to an applied magnetic force, and this property of MNPs has been utilized in applications such as diagnosis of diseases, drug delivery and drug targeting. Currently, MNPs have attracted great attention because of their potential as contrast agents for magnetic resonance imaging (MRI) and heat mediators for cancer therapy (hyperthermia). Read More

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http://dx.doi.org/10.2174/1872211311666170328150747DOI Listing
August 2018
5 Reads

Environmentally Responsive Systems for Drug Delivery.

Recent Pat Drug Deliv Formul 2017 ;11(2):89-100

Postgraduate Program in Pharmaceutical Sciences, Laboratory of Research and Development of Drug Delivery Systems, Department of Pharmacy, State University of Maringa, Maringa. Brazil.

Background: In recent decades, the development of the environmentally responsive systems for drug delivery has been well regarded, with enormous potential in different applications. <P><P> Methods: These environmentally sensitive, smart, intelligent formulations have the ability to alter their physical properties in response to small changes in physical or chemical conditions, such as temperature, glucose, pH, ultrasound, light, electric field and redox potential with a huge potential in drug delivery systems. The use of formulations containing smart materials enables to carry the drug to the target tissue, cells and release in a triggered way. Read More

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http://www.eurekaselect.com/151163/article
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http://dx.doi.org/10.2174/1872211311666170328151455DOI Listing
August 2018
38 Reads

Probiotics as a Tool to Biosynthesize Metallic Nanoparticles: Research Reports and Patents Survey.

Recent Pat Drug Deliv Formul 2017 ;11(1):5-18

Department of Pharmaceutics, Pharmacy College Saifai, Uttar Pradesh University of Medical Sciences, Saifai, Etawah- 206130, Uttar Pradesh, India.

Background: Probiotics are the live microbes that exert beneficial effects on the health of the host cell, creating novel nanoformulations via probiotic bacteria, thus gaining tremendous momentum recently. The probiotic bacteria are being employed in synthesizing or more specifically biosynthesizing several nanoparticles like metallic as well as non-metallic nanoparticles. Biosynthesis of metallic nanoparticles is currently the focus of research nowadays due to several applications. Read More

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http://dx.doi.org/10.2174/1872211311666170313124335DOI Listing
January 2018
3 Reads

Preparation and Optimization of Fast Dissolving Film of Naratr iptan Hydrochloride.

Recent Pat Drug Deliv Formul 2017 ;11(2):124-131

Department of Pharmaceutical Sciences, Saurashtra University, Rajkot 360005, Gujarat. India.

Background: Naratriptan is second-generation triptan class of antimigraine drug which selectively bind with 5-HT(1B/1D) receptor. It is widely used to treat the migraine attack due to its better tolerability and lower recurrence rate as compared to other triptans. Despite of the applicability, Naratriptan also have several drawback like slow onset of action and fist pass metabolism which reduce its efficacy. Read More

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http://dx.doi.org/10.2174/1872211311666170213105001DOI Listing
August 2018
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Development and Characterization Pulsatile Microspheres of Nifedipine for Hypertension.

Recent Pat Drug Deliv Formul 2017 ;11(1):67-76

Department of Pharmaceutical Research Division, Amar Shaheed Baba AjIt Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab, India; Affiliated to IKG Punjab Technical University, Jalandhar, India.

Background: To develop pulsatile microspheres of Nifedipine blend of polymers Carbopol 971P and Eudragit RS100 for antihypertensive to release the drug at a particular lag time.

Methods: Pulsatile nifedipine microspheres were prepared using the blend of Carbopol 971P and Eudragit RS100 at different ratios in a mixture of solvents. Formulations were prepared and optimized on the basis of particle size, percentage yield and drug entrapment efficiency. Read More

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http://dx.doi.org/10.2174/1872211311666170213104321DOI Listing
January 2018
37 Reads

Acyclovir Solid Lipid Nanoparticles for Skin Drug Delivery: Fabrication, Characterization and In vitro Study.

Recent Pat Drug Deliv Formul 2017 ;11(2):132-146

Department of Pharmaceutics, Rayat-Bahra Institute of Pharmacy, Rayat-Bahra University, Punjab. India.

Objective: The fractionated coconut oil based Solid Lipid Nanoparticles (SLNs) of Acyclovir (ACV) were fabricated in two batches by using Glyceryl mono stearate (GMS) and Lipoid S75 (Fat free soybean phospholipids with 70% phosphatidylcholine-Lipoid GmbH, Germany). The research was focused on developing ACV-SLN by using high pressure hot-homogenization technique. The ingredients were used in different concentrations and ratios to identify the best formulation design. Read More

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http://dx.doi.org/10.2174/1872211311666170117123403DOI Listing
August 2018
8 Reads

Formulation Development and Evaluation of Lyophilized Nasal Inserts for Migraine Treatment.

Recent Pat Drug Deliv Formul 2017 ;11(1):42-53

Department of Pharmaceutics, SNJB's SSDJ College of Pharmacy, Chandwad, Dist. Nashik, Maharashtra, India.

Background: Nasal inserts are novel, solid, bioadhesive dosage forms administered via nasal route for prolonged systemic drug delivery. The principle of the dosage form is that, after administration nasal inserts imbibe nasal fluid from the mucosa and form a gel in the nasal cavity in order to avoid foreign body sensation. The objective of this investigation was the development of chitosan/xanthan gum based bioadhesive nasal inserts of antimigraine drug. Read More

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http://www.eurekaselect.com/149377/article
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http://dx.doi.org/10.2174/1872211311666170118112002DOI Listing
January 2018
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Formulation and Optimization of Lansoprazole Pellets Using Factorial Design Prepared by Extrusion-Spheronization Technique Using Carboxymethyl Tamarind Kernel Powder.

Recent Pat Drug Deliv Formul 2017 ;11(1):54-66

Departmment of Pharmaceutics, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra 411018, India.

Background: In the present study, Lansoprazole pellets were prepared employing a novel excipient Carboxymethyl tamarind kernel powder (CMTKP) using extrusion-spheronization technique. Various research studies including patents have been carried out on this polymer. Pellet formulation was optimized for formulation parameters (concentration of microcrystalline cellulose, CMTKP, croscarmellose sodium and isopropyl alcohol). Read More

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http://www.eurekaselect.com/149264/article
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http://dx.doi.org/10.2174/1872211311666170113150248DOI Listing
January 2018
18 Reads