997,611 results match your criteria Recent Patents on Drug Delivery and Formulation [Journal]


A Farewell to Falsity: Shifting Standards in Medicare Fraud Enforcement.

Authors:
Isaac D Buck

Seton Hall Law Rev 2019 ;49(1):1-51

University of Tennessee College of Law.

For the better part of a decade, Americans have had a front-row seat to a fervent and turbulent debate over the future of their health care system. The passage of the Patient Protection and Affordable Care Act of 2010 (ACA), the most comprehensive health reform effort since the mid-1960s, ushered in a new era in health law and policy, granting millions of Americans access to health care. After multiple legal challenges and congressional efforts that ultimately failed to slay the law, the ACA had become entrenched by the end of the Obama administration, even though pieces of the law had failed to work exactly as planned. Read More

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January 2019

Apolipoprotein CIII and diabetes. Is there a link?

Diabetes Metab Res Rev 2018 Dec 17:e3118. Epub 2018 Dec 17.

Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece.

Apolipoprotein CIII (ApoCIII), a small protein that resides on the surface of lipoprotein particles, is a key regulator of triglyceride metabolism. The inhibition of lipoprotein lipase (LPL), the increased assembly and secretion of very low-density lipoproteins (VLDL) and the decreased reuptake of triglyceride-rich lipoproteins (TRLs) by the liver are mechanisms associating elevated serum ApoCIII levels and hypertriglyceridemia. ApoCIII concentration is high in individuals with diabetes mellitus indicating a possible positive correlation with impairment of glucose metabolism. Read More

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December 2018

Short-Term Steroid Regimen for Adult Steroid-Sensitive Minimal Change Disease.

Am J Nephrol 2018 Dec 17;49(1):54-63. Epub 2018 Dec 17.

Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya,

Background: In pediatric patients with steroid-sensitive nephrotic syndrome, recent trials have revealed that a 2-month, short-term steroid regimen is not inferior to an extended steroid course. However, the optimal duration of initial steroid therapy for adult steroid-sensitive minimal change disease (MCD) remains unclear.

Objectives: The aim of present study was to evaluate the effectiveness of a 2-month, short-term steroid regimen in the treatment of adult steroid-sensitive MCD patients. Read More

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December 2018

Testing the gene expression classification of the EMT spectrum.

Phys Biol 2018 Dec 17. Epub 2018 Dec 17.

Department of Bioengineering, Rice University, 6100 Main Street, MS-142, Houston, TX 77251-1892, USA, Houston, Texas, UNITED STATES.

The epithelial-mesenchymal transition (EMT) plays a central role in cancer metastasis and drug resistance - two persistent clinical challenges. Epithelial cells can undergo a partial or full EMT, attaining either a hybrid epithelial/mesenchymal (E/M) or mesenchymal phenotype, respectively. Recent studies have emphasized that hybrid E/M cells may be more aggressive than their mesenchymal counterparts. Read More

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December 2018

Exploration of high-pressure structural transition and electronic properties of BaFe2S3.

J Phys Condens Matter 2018 Dec 17. Epub 2018 Dec 17.

Qinghai University, Xining, Qinghai, CHINA.

The iron-based compound BaFe<sub>2</sub>S<sub>3</sub> has received considerable attention in recent years due to their unique electronic properties with important applications. But, there has been relatively little attention devoted to the structure evolution of BaFe<sub>2</sub>S<sub>3</sub> under high pressure. Here, we report a detailed theoretical study of the structural, electronic and sound velocity properties of BaFe<sub>2</sub>S<sub>3</sub> under high pressure by CALYPSO structure search method in combination with the first-principles calculations. Read More

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December 2018

REM theta activity predicts re-experiencing symptoms after exposure to a traumatic film.

Sleep Med 2018 Nov 19;54:142-152. Epub 2018 Nov 19.

Division of Clinical Psychology and Psychotherapy, Department of Psychology, Saarland University, Campus A1 3, D-66123 Saarbrücken, Germany.

Background: Extensive empirical evidence indicates that sleep plays an active role in memory consolidation. Moreover, sleep has been found to preferentially enhance emotional memories and may modulate affective reactions to previously encountered stimuli. Notably, recent findings suggest that disruptions of sleep-related memory processing could be involved in posttraumatic symptom development such that sleep disturbances may accelerate symptoms of intrusive re-experiencing. Read More

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November 2018
1 Read

Current antifungal drugs and immunotherapeutic approaches as promising strategies to treatment of fungal diseases.

Biomed Pharmacother 2018 Dec 14;110:857-868. Epub 2018 Dec 14.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Invasive candidiasis (IC) can affect individuals with various underlying diseases hospitalized in different parts of hospitals. In recent decades, IC has caused 27-55% mortality in general population. Although Candida albicans (C. Read More

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December 2018

Visible-light-driven photocatalytic degradation of diclofenac by carbon quantum dots modified porous g-CN: Mechanisms, degradation pathway and DFT calculation.

Water Res 2018 Dec 3;150:431-441. Epub 2018 Dec 3.

Key Laboratory of Three Gorges Reservoir Region's Eco-Environment, Ministry of Education, Chongqing University, Chongqing, 400045, PR China. Electronic address:

Metal-free photocatalysts have attracted growing concern in recent years. In this work, a new class of carbon quantum dots (CQDs) modified porous graphitic carbon nitride (g-CN) is synthesized via a facile polymerization method. With the optimal CQDs loading, the CQDs modified g-CN exhibits ∼15 times higher degradation kinetic towards diclofenac (DCF) than that of pure g-CN. Read More

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December 2018
3 Reads

Stability of synthetic cathinones in blood and urine.

Forensic Sci Int 2018 Dec 6;295:36-45. Epub 2018 Dec 6.

Jagiellonian University, Faculty of Chemistry, Gronostajowa 2, 30-387 Kraków, Poland.

Introduction: Although there is an observed decline in the number of new psychoactive substances entering the drug market, this phenomenon is still a significant public health problem. Synthetic cathinones are the second largest group of new substances and currently belong to the most frequently confiscated. Their availability and prevalence cause that they are often abused. Read More

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December 2018
1 Read

Identification of novel PPARα/γ dual agonists by pharmacophore screening, docking analysis, ADMET prediction and molecular dynamics simulations.

Comput Biol Chem 2018 Nov 27;78:178-189. Epub 2018 Nov 27.

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, China. Electronic address:

PPARα and PPARγ play an important role in regulating glucose and lipid metabolism. The single and selective PPARα or PPARγ agonists have caused several side effects such as edema, weight gain and cardiac failure. In the recent years, the dual PPARs agonist development has become a hot topic in the antidiabetic medicinal chemistry field. Read More

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November 2018

Smoking cessation in the context of recovery from drug and alcohol problems: Prevalence, predictors, and cohort effects in a national U.S. sample.

Drug Alcohol Depend 2018 Dec 8;195:6-12. Epub 2018 Dec 8.

Recovery Research Institute, Massachusetts General Hospital and Harvard Medical School, 151 Merrimac Street, Boston, MA, 02114, USA.

Background: Tobacco and alcohol and other drug (AOD) use remain prominent risk factors for morbidity, mortality, and health care utilization. Moreover, these often cluster together within persons, exponentiating health risks. Little is known regarding if and when people resolving AOD problems stop smoking, who stops, and whether recent general population trends toward smoking cessation are evident also among persons more recently entering recovery. Read More

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December 2018

Flux modeling for monolignol biosynthesis.

Curr Opin Biotechnol 2018 Dec 14;56:187-192. Epub 2018 Dec 14.

State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin 150040, China; Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC 27695, United States. Electronic address:

The pathway of monolignol biosynthesis involves many components interacting in a metabolic grid to regulate the supply and ratios of monolignols for lignification. The complexity of the pathway challenges any intuitive prediction of the output without mathematical modeling. Several models have been presented to quantify the metabolic flux for monolignol biosynthesis and the regulation of lignin content, composition, and structure in plant cell walls. Read More

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December 2018

Discovering market segments for hunted wild game meat.

Meat Sci 2018 Nov 29;149:163-176. Epub 2018 Nov 29.

Department of Health, Animal Science and Food Safety, Università degli Studi di Milano, Via Celoria, 10, 20133 Milano, Italy. Electronic address:

Recent years have seen a notable increase in the popularity of hunted wild game meat (HWGM) among consumers. This has led to a growing number of emerging markets for HWGM in many developed countries, including Europe. However, expansion of these markets is often hampered by the lack of a professional supply chain. Read More

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November 2018

Mapping whole brain connectivity changes: The potential impact of different surgical resection approaches for temporal lobe epilepsy.

Cortex 2018 Nov 17;113:1-14. Epub 2018 Nov 17.

Neuroscience and Aphasia Research Unit, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, UK; MRC Cognition and Brain Sciences Unit, University of Cambridge, UK. Electronic address:

In neurosurgery there are several situations that require transgression of the temporal cortex. For example, a subset of patients with temporal lobe epilepsy require surgical resection (most typically, en-bloc anterior temporal lobectomy). This procedure is the gold standard to alleviate seizures but is associated with chronic cognitive deficits. Read More

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November 2018
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Cellular responses to thermoresponsive stiffness memory elastomer nanohybrid scaffolds by 3D-TIPS.

Acta Biomater 2018 Dec 14. Epub 2018 Dec 14.

Centre for Biomaterials in Surgical Reconstruction and Regeneration, Division of Surgery & Interventional Science, University College London, London, NW3 2PF, United Kingdom. Electronic address:

Increasing evidence suggests the contribution of the dynamic mechanical properties of the extracellular matrix (ECM) to regulate tissue remodeling and regeneration. Following our recent study on a family of thermoresponsive 'stiffness memory' elastomeric nanohybrid scaffolds manufactured via an indirect 3D printing guided thermo-induced phase separation process (3D-TIPS), this work reports in vitro and in vivo cellular responses towards these scaffolds with different initial stiffness and hierarchical interconnected porous structure. The viability of mouse embryonic dermal fibroblasts in vitro and the tissue responses during the stiffness softening of the scaffolds subcutaneously implanted in rats for three months were evaluated by immunohistochemistry and histology. Read More

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December 2018

Cerebrospinal fluid ferritin levels predict brain hypometabolism in people with underlying β-amyloid pathology.

Neurobiol Dis 2018 Dec 14. Epub 2018 Dec 14.

Melbourne Dementia Research Centre, The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia; Cooperative Research Center for Mental Health, Victoria, Australia. Electronic address:

β-Amyloid pathology is elevated in ~30% of cognitively normal people over 65, and is associated with accelerated neurodegeneration in the pre-clinical stages of Alzheimer's disease. Recent findings reveal that brain iron might also act to propel neurodegeneration in people with underlying amyloid pathology. Here, repeated PET scans of fluorodeoxyglucose (FDG) were used as a biomarker for brain hypometabolism and a downstream biomarker of neurodegeneration to investigate whether levels of ferritin in the cerebrospinal fluid (CSF; a reporter of brain iron load) are associated with prodromal disease progression of people with high β-amyloid pathology determined by established cut-off values in CSF t-tau/Aβ ratio. Read More

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December 2018

Quality-by-design approach as a systematic tool for the development of nanopharmaceutical products.

Drug Discov Today 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi-110062, India. Electronic address:

In recent decades, extensive emphasis has been given on developing nanopharmaceutical products for improving the therapeutic performance of drugs, resulting in an increasing number of product approvals by drug regulatory agencies. Although nanopharmaceuticals are subjected to the same regulatory pathways as conventional pharmaceutical products, their biopharmaceutical characteristics at the nanoscale make them vulnerable to high variability in quality. Positive effects on drug quality assurance have resulted from adopting systematic quality-by-design (QbD) principles, boosting pharmaceutical manufacturing with improvements in the quality, safety, and efficacy of drugs. Read More

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December 2018

Mechanisms of cardiac ethanol toxicity and novel treatment options.

Pharmacol Ther 2018 Dec 14. Epub 2018 Dec 14.

Department of Internal Medicine II, University Medical Center Regensburg, Germany. Electronic address:

Ethanol can acutely and chronically alter cardiomyocyte and whole-organ function in the heart. Importantly, ethanol acutely and chronically predisposes to arrhythmias, while chronic abuse can induce heart failure. However, the molecular mechanisms of ethanol toxicity in the heart are incompletely understood. Read More

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December 2018

Expression of immediate early genes in brain reward circuitries: Differential regulation by psychostimulant and opioid drugs.

Neurochem Int 2018 Dec 14. Epub 2018 Dec 14.

NIDA Intramural Program, Molecular Neuropsychiatry Research Branch, 251 Bayview Boulevard, Baltimore, MD, 21224, USA. Electronic address:

Although some of the clinical manifestations of substance use disorders might be superficially similar, it is highly likely that different classes of abused drugs including opioids (heroin, morphine, and oxycodone, other opioids) and psychostimulants (cocaine and amphetamines) cause different neuroadaptations in various brain regions dependent in the distribution and concentration of their biochemical sites of actions. In fact, different molecular networks are indeed impacted by acute and chronic administration of addictive substances. Some of the genes whose expression is influenced by the administration of these substances are immediate-early genes (IEGs). Read More

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December 2018

Association between excreta management and extended-spectrum β-lactamase producing Enterobacteriaceae incidence rate: Role of health-care worker's knowledge and practices.

J Hosp Infect 2018 Dec 14. Epub 2018 Dec 14.

MiHAR Lab (www.mihar.univ-nantes.fr), University of Nantes, Nantes, FR-44000; Bacteriology and Infection Control Department, Nantes University Hospital, Nantes, FR-44000. Electronic address:

Background: The spread of extended-spectrum β-lactamase producing Enterobacteriaceae (ESBL-PE) in healthcare environments has become a major public health threat in recent years.

Aim: To assess how healthcare workers (HCWs) manage excreta and the possible association with ESBL-PE incidence.

Methods: 800 HCWs and 74 nurse-supervisors were questioned through 2 self-report questionnaires in order to assess their knowledge and practices, and to determine the equipment utilized for excreta management in 74 healthcare departments. Read More

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December 2018

Lung cancer stem cells: origin, features, maintenance mechanisms and therapeutic targeting.

Biochem Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

Lung cancer remains the leading cause of cancer-related deaths despite recent breakthroughs in immunotherapy. The widely embraced cancer stem cell (CSC) theory has also been applied for lung cancer, postulating that an often small proportion of tumor cells with stem cell properties are responsible for tumor growth, therapeutic resistance and metastasis. The identification of these CSCs and underlying molecular maintenance mechanisms is considered to be absolutely necessary for developing therapies for their riddance, hence achieving remission. Read More

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December 2018

Sera selected from national STI surveillance system shows Chlamydia trachomatis PgP3 antibody correlates with time since infection and number of previous infections.

PLoS One 2018 17;13(12):e0208652. Epub 2018 Dec 17.

Health Protection Research Unit in Evaluation of Interventions at University of Bristol in partnership with Public Health England, Bristol, United Kingdom.

Background: Seroprevalence surveys of Chlamydia trachomatis (CT) antibodies are promising for estimating age-specific CT cumulative incidence, however accurate estimates require improved understanding of antibody response to CT infection.

Methods: We used GUMCAD, England's national sexually transmitted infection (STI) surveillance system, to select sera taken from female STI clinic attendees on the day of or after a chlamydia diagnosis. Serum specimens were collected from laboratories and tested anonymously on an indirect and a double-antigen ELISA, both of which are based on the CT-specific Pgp3 antigen. Read More

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December 2018

The role of Pleistocene climate change in the genetic variability, distribution and demography of Proechimys cuvieri and P. guyannensis (Rodentia: Echimyidae) in northeastern Amazonia.

PLoS One 2018 17;13(12):e0206660. Epub 2018 Dec 17.

Institut Pasteur de la Guyane, Cayenne cedex, French Guiana.

The spiny rats, genus Proechimys, have the highest species richness within the Echimyidae family, as well as species with high genetic variability. The genus distribution includes tropical South America and Central America south to Honduras. In this study, we evaluate the phylogeographic histories of Proechimys guyannensis and P. Read More

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December 2018

How do complex animal signals evolve?

Authors:
Chad M Eliason

PLoS Biol 2018 Dec 17;16(12):e3000093. Epub 2018 Dec 17.

Integrative Research Center, Field Museum of Natural History, Chicago, United States of America.

Animal signals-involving combinations of acoustic, chemical, visual, and behavioral cues-are among the most diverse traits in nature. Testing hypotheses about signal evolution has been hampered by difficulties with comparing highly divergent signals among species. In this Primer, I describe recent advances in capturing signals and studying their evolution. Read More

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December 2018

Cell-intrinsic regulation of peripheral memory-phenotype T cell frequencies.

PLoS One 2018 17;13(12):e0200227. Epub 2018 Dec 17.

National Institute of Immunology, New Delhi, India.

Memory T and B lymphocyte numbers are thought to be regulated by recent and cumulative microbial exposures. We report here that memory-phenotype lymphocyte frequencies in B, CD4 and CD8 T-cells in 3-monthly serial bleeds from healthy young adult humans were relatively stable over a 1-year period, while Plasmablast frequencies were not, suggesting that recent environmental exposures affected steady state levels of recently activated but not of memory lymphocyte subsets. Frequencies of memory B and CD4 T cells were not correlated, suggesting that variation in them was unlikely to be determined by cumulative antigenic exposures. Read More

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December 2018

Automatic interpretation of otoliths using deep learning.

PLoS One 2018 17;13(12):e0204713. Epub 2018 Dec 17.

Institute of Marine Research, Bergen, Norway.

The age structure of a fish population has important implications for recruitment processes and population fluctuations, and is a key input to fisheries-assessment models. The current method of determining age structure relies on manually reading age from otoliths, and the process is labor intensive and dependent on specialist expertise. Recent advances in machine learning have provided methods that have been remarkably successful in a variety of settings, with potential to automate analysis that previously required manual curation. Read More

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December 2018

Widespread circulation of West Nile virus, but not Zika virus in southern Iran.

PLoS Negl Trop Dis 2018 Dec 17;12(12):e0007022. Epub 2018 Dec 17.

Department of Clinical Virology, Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Namazi Hospital, Shiraz, Iran.

West Nile virus (WNV) and Zika virus (ZIKV) are mosquito-borne viral infections. Over the past few decades, WNV has been associated with several outbreaks involving high numbers of neuroinvasive diseases among humans. The recent re-emergence of ZIKV has been associated with congenital malformation and also with Guillain-Barre syndrome in adults. Read More

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December 2018
1 Read

Williams syndrome: recent advances in our understanding of cognitive, social and psychological functioning.

Curr Opin Psychiatry 2018 Dec 14. Epub 2018 Dec 14.

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Purpose Of Review: Since the last review of Williams syndrome in Current Opinion (2001) there have been many advances in knowledge about the cognitive, social and psychological impairments that characterize the disorder. The present review focuses on current research in these areas.

Recent Findings: Williams syndrome is associated with a wide range of cognitive, linguistic, social and other difficulties. Read More

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December 2018

Behavior and sleep disturbance in Smith-Magenis syndrome.

Curr Opin Psychiatry 2018 Dec 14. Epub 2018 Dec 14.

Department of Molecular and Human Genetics, Baylor College of Medicine.

Purpose Of Review: To provide an update of the most recent studies on Smith-Magenis syndrome (SMS) with a focus on the unique pattern of behavioral and sleep disturbances associated with the condition.

Recent Findings: The recent literature on SMS has focused on the characteristic severe behavioral and sleep disturbances. A better understanding of the underlying pathophysiological mechanisms and common clinical course has helped further characterize SMS, while much is left to be discovered in regard to effective treatment/management. Read More

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December 2018

Understanding and predicting the longitudinal course of dementia.

Curr Opin Psychiatry 2018 Dec 14. Epub 2018 Dec 14.

Centre for Dementia Prevention, University of Edinburgh, Edinburgh, UK.

Purpose Of Review: To date, most research in dementia has focused either on the identification of dementia risk prediction or on understanding changes and predictors experienced by individuals before diagnosis. Despite little is known about how individuals change after dementia diagnosis, there is agreement that changes occur over different time scales and are multidomain. In this study, we present an overview of the literature regarding the longitudinal course of dementia. Read More

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December 2018
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Diagnosis and management of foetal alcohol specturm disorder.

Curr Opin Psychiatry 2018 Dec 14. Epub 2018 Dec 14.

FASD Specialist Behaviour Clinic, Surrey and Borders Partnership NHS Foundation Trust, Redhill, UK.

Purpose Of Review: Our understanding of the diagnosis and management of Foetal Alcohol Spectrum Disorders (FASD), has been increasingly refined in the last 45 years: This review highlights current understanding and identifies future areas for research.

Recent Findings: Newer techniques such as three-dimensional facial recognition and advanced brain imaging, have advanced our understanding. Despite this, there remain areas, such as the relationship with other neurodevelopmental disorders, that have been insufficiently explored. Read More

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December 2018

Stem cell therapies for Alzheimer's disease: is it time?

Curr Opin Psychiatry 2018 Dec 14. Epub 2018 Dec 14.

Department of Psychiatry, Yeouido St. Mary's Hospital.

Purpose Of Review: Stem cell therapy has the potential to modify the disease of Alzheimer's disease. This article aims to describe the mechanisms of action, preclinical animal studies, human clinical trials, and challenges for the future direction of stem cell therapy for Alzheimer's disease.

Recent Findings: Stem cells of diverse origins (embryonic, placental or umbilical cord blood, and induced pluripotent stem cells) and cell types (neural and mesenchymal stem cells) are widely studied in both animals and humans. Read More

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December 2018

The Experiences of Black Nursing Alumni at a Predominantly White Institution.

Nurse Educ 2018 Dec 13. Epub 2018 Dec 13.

Author Affiliations: Assistant Professor, FNP Track Co-Coordinator (Dr Gona); Assistant Professor (Dr Pusey-Reid), Accelerated BSN Program; Assistant Dean (Dr Lussier-Duynstee), Student Services and Clinical Facilitation; and Former Faculty (Dr Gall), School of Nursing, MGH Institute of Health Professions, Boston, Massachusetts.

Background: Despite increasing minority enrollment in nursing programs, student attrition remains a persistent problem.

Purpose: The purpose of this study was to describe the experiences of a diverse group of black alumni at a predominantly white institution in the United States.

Method: In this qualitative descriptive study, researchers conducted focus group interviews with 16 recent graduates of accelerated baccalaureate and direct-entry nurse practitioner programs. Read More

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December 2018

Immature electrophysiological properties of human-induced pluripotent stem cell-derived neurons transplanted into the mouse cortex for 7 weeks.

Neuroreport 2018 Dec 15. Epub 2018 Dec 15.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo.

The transplantation of human-induced pluripotent stem cell (hiPSC)-derived cells has emerged as a potential clinical approach for the treatment of brain diseases. Recent studies with animal disease models have shown that hiPSC-derived neurons transplanted into the brain, especially the nigrostriatal area, could restore degenerated brain functions. Further works are required to test whether hiPSC-derived neurons can also gain functional properties for other cortical areas. Read More

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December 2018

Effects of Binge Drinking on the Developing Brain.

Alcohol Res 2018 ;39(1):87-96

Scott A. Jones and Jordan M. Lueras are graduate students in the Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon. Bonnie J. Nagel, Ph.D., is an associate professor in the Departments of Behavioral Neuroscience and Psychiatry, Oregon Health & Science University, Portland, Oregon.

Binge drinking is a pattern of alcohol drinking that raises a person's blood alcohol concentration to at least .08%, which amounts to consuming five alcoholic drinks for men and four alcoholic drinks for women in about 2 hours. It is the most common form of alcohol misuse in adolescents and young adults. Read More

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January 2018

"Maturing Out" of Binge and Problem Drinking.

Alcohol Res 2018 ;39(1):31-42

Matthew R. Lee, Ph.D., is research assistant professor, Department of Psychological Sciences, University of Missouri, Columbia, Missouri. Kenneth J. Sher, Ph.D., is curators' distinguished professor, Department of Psychological Sciences, University of Missouri, Columbia, Missouri.

This article reviews literature aiming to explain the widespread reductions in binge and problem drinking that begin around the transition to young adulthood (i.e., "maturing out"). Read More

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January 2018

Adolescent Binge Drinking.

Alcohol Res 2018 ;39(1):5-15

Tammy Chung, Ph.D., is an associate professor; Rachel Bachrach, Ph.D., is a postdoctoral fellow; Duncan B. Clark, M.D., Ph.D., is a professor; and Christopher S. Martin, Ph.D., is an associate professor, all in the Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania. Kasey G. Creswell, Ph.D., is an assistant professor in the Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania.

Binge drinking, commonly defined as consuming five or more standard drinks per occasion for men and four or more drinks for women, typically begins in adolescence. Adolescents, although they may drink less often, tend to consume higher quantities of alcohol per occasion compared with adults. This developmental difference in pattern of alcohol consumption may result, in part, from maturational changes that involve an adolescent-specific sensitivity to certain alcohol effects and greater propensity for risk-taking behaviors, such as binge drinking. Read More

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January 2018

What's wrong with neutrophils in lupus?

Clin Exp Rheumatol 2018 Nov 19. Epub 2018 Nov 19.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Polymorphonuclear neutrophils (PMNs) act by promoting phagocytosis, and are regarded as the first line of defense against pathogen invasion. However, recent investigations have revealed that they have many previously unknown functions. These functions include mitogen-induced cell-mediated cytotoxicity, production of cytokines/chemokines/growth factors, and release of neutrophil extracellular traps (NETs) and ectosomes/exosomes. Read More

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November 2018

AN INTERFERON GAMMA RELEASE ASSAY FOR THE DETECTION OF IMMUNE SENSITIZATION TO MYCOBACTERIUM BOVIS IN AFRICAN WILD DOGS ( LYCAON PICTUS).

J Wildl Dis 2018 Dec 17. Epub 2018 Dec 17.

1   Department of Science and Technology-National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

In South Africa, the largest proportion of the African wild dog ( Lycaon pictus) population resides in regions where buffaloes have a high prevalence of Mycobacterium bovis, the causative agent of bovine tuberculosis (bTB). Recent reports of deaths of wild dogs associated with bTB have raised concerns regarding the threat this disease might pose for this species. In order to understand the potential impact of the disease in wild dogs, diagnostic tools are required to identify infected individuals. Read More

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December 2018

New insights into the pathophysiology of IgG4-related disease and markers of disease activity.

Expert Rev Clin Immunol 2018 Dec 17. Epub 2018 Dec 17.

a Division of Rheumatology, Department of Internal Medicine , Kanazawa University Graduate School of Medicine , Kanazawa , Japan.

Introduction: Recently, IgG4-related disease (IgG4-RD) has become a well-recognized clinical entity, although its causes are still not well understood. The pathophysiology of IgG4-RD has been reported from a variety of aspects. Areas covered: In this review, we outline a number of recent advances in our understanding of the pathogenesis of IgG4-RD, divided according to acquired immunology and innate immunology and other topics. Read More

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December 2018
3 Reads

The front line of research into immunoglobin (Ig) G4-related disease - Do autoantibodies cause IgG4-RD?

Mod Rheumatol 2018 Dec 17:1-11. Epub 2018 Dec 17.

d First Department of Internal Medicine , University of Occupational and Environmental Health , Kitakyushu , Japan.

IgG4-related disease (IgG4-RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells. Although IgG4-RD is attracting strong attention as a new clinical entity, the pathogenesis of IgG4-RD and the roles of IgG4 are still unknown. Recently, self-antigens including Laminin 511 E8, Galectin-3 and Annexin A11, have been reported from one to the next as autoantigens which may be involved in the pathogenesis of IgG4-RD. Read More

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December 2018

Remission of proteinuria under therapeutic intervention and the renal outcomes in Japanese patients with lupus nephritis class III and IV.

Mod Rheumatol 2018 Dec 17:1-17. Epub 2018 Dec 17.

a Division of Nephrology and Hypertension, Department of Internal Medicine , The Jikei University School of Medicine , Tokyo , Japan.

Background: Recent studies have identified the significance of proteinuria levels after initial induction therapies on the renal outcomes in patients with proliferative lupus nephritis, but the issue has not been evaluated in Japanese patients.

Methods: Based on the ISN/RPS classification, only patients diagnosed as lupus nephritis class III or IV were included. The remission of proteinuria twelve months after diagnosis, as well as the clinicopathological features at diagnosis, on renal outcomes was examined retrospectively. Read More

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December 2018

Prostate transmembrane protein androgen induced 1 is induced by activation of osteoclasts and regulates bone resorption.

FASEB J 2018 Dec 17:fj201801573R. Epub 2018 Dec 17.

Department of Pathology and Microbiology, Faculty of Medicine, Saga University, Saga, Japan.

Osteoclasts derived from hematopoietic cells are activated on bone surface. To resorb bone, osteoclasts release acid and lysosome acid hydrolase via membrane transport. Prostate transmembrane protein androgen-induced (Pmepa)1 is a type I transmembrane protein that regulates proliferation, migration, and metastasis of cancer cells. Read More

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December 2018

The mA writer: Rise of a machine for growing tasks.

Biochemistry 2018 Dec 17. Epub 2018 Dec 17.

The central dogma of molecular biology introduced by Crick describes a linear flow of information from DNA to mRNA to protein. Since then it has become evident that RNA undergoes several maturation steps such as capping, splicing, 3'-end processing and editing. Likewise, nucleotide modifications are common in mRNA and are present in all organisms impacting on the regulation of gene expression. Read More

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December 2018

Use of proton pump inhibitors among Danish children: a 16-year register-based nationwide study.

Basic Clin Pharmacol Toxicol 2018 Dec 17. Epub 2018 Dec 17.

Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern, Denmark.

Objectives: Proton pump inhibitors (PPI) are among the most frequently used drugs in the developed countries. In recent years, their use among children and adolescents has been on the increase. Guidelines recommend use for a period no longer than 4-8 weeks. Read More

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December 2018

Multicomponent structures in camouflage and mimicry in butterfly wing patterns.

J Morphol 2019 Jan;280(1):149-166

Transgenic Silkworm Research Unit, Division of Biotechnology, Institute of Agrobiological Sciences, NARO, Ibaraki, Japan.

Understanding how morphological structures are built is essential for appreciating the morphological complexity and divergence of organisms. One representative case of morphological structures is the camouflage and mimicry of butterfly wing patterns. Some previous studies have questioned whether camouflage and mimicry are truly structures, considering that they rely on coloration. Read More

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January 2019

Nutritional strategies for psoriasis: current scientific evidence in clinical trials.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8537-8551

Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.

Objective: Several nutritional strategies for the management of psoriasis are promising. Even if recent data support that nutrition may play a pivotal role in prevention and co-treatment and despite patient's concerns regarding the best nutritional habits, the consensus regarding the nutritional strategies to be adopted lacks in clinical settings. In this manuscript, the effects of several nutritional strategies for psoriasis patients such as hypocaloric diet, vitamin D, fish oil, selenium, and zinc supplementation were systematically reviewed. Read More

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December 2018
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Rational chemical doping of metal halide perovskites.

Chem Soc Rev 2018 Dec 17. Epub 2018 Dec 17.

State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China.

Metal halide perovskites benefit from the combination of wide absorption, high carrier mobility, defect tolerance, moderate exciton binding energies, and versatility of solution processes, showing great promise in photovoltaics and optoelectronics. However, the issues of long-term instability and toxicity of lead are supposed to limit their further practical applications. Chemical doping of an impurity into metal halide perovskites was reported to be a relatively effective approach to solving these issues while providing additional tunable physical and chemical properties. Read More

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December 2018

Kocuria tytonis sp. nov., isolated from the uropygial gland of an American barn owl (Tyto furcata).

Int J Syst Evol Microbiol 2018 Dec 17. Epub 2018 Dec 17.

1​Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, INF 364, 69120 Heidelberg, Germany.

Avian uropygial glands have received increasing attention in recent years, but little is known about micro-organisms in uropygial glands. In this study, we isolated a strain of Gram-stain-positive, non-motile, non-spore-forming cocci, designated 442, from the uropygial gland of an American barn owl (Tyto furcata) and characterized it using a polyphasic approach. 16S rRNA gene sequence analysis placed the isolate in the genus Kocuria. Read More

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December 2018

RNA processing in skeletal muscle biology and disease.

Transcription 2018 Dec 17. Epub 2018 Dec 17.

a Curriculum in Genetics and Molecular Biology (GMB) , University of North Carolina at Chapel Hill , USA.

RNA processing encompasses the capping, cleavage, polyadenylation and alternative splicing of pre-mRNA. Proper muscle development relies on precise RNA processing, driven by the coordination between RNA-binding proteins. Recently, skeletal muscle biology has been intensely investigated in terms of RNA processing. Read More

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December 2018
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