174 results match your criteria Recent Patents on DNA and Gene Sequences [Journal]


Energy crops for biofuel feedstocks: facts and recent patents on genetic manipulation to improve biofuel crops.

Authors:
Suresh Kumar

Recent Pat DNA Gene Seq 2013 Dec;7(3):187-94

Division of Biochemistry, Indian Agricultural Research Institute, New Delhi-110012, India.

Burning fossil-fuels to meet the global energy requirements by human being has intensified the concerns of increasing concentrations of greenhouse gases. Therefore, serious efforts are required to develop nonfossil-based renewable energy sources. Plants are more efficient in utilizing solar energy to convert it into biomass which can be used as feedstocks for biofuel production. Read More

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December 2013
4 Reads

Functional genome-wide analysis: a technical review, its developments and its relevance to cancer research.

Recent Pat DNA Gene Seq 2013 Aug;7(2):157-66

Institute of Cancer & Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.

A technique has emerged over the past decade combining chromatin immunoprecipitation with DNA microarray analysis. This is a powerful and sensitive strategy that has been used extensively to characterise protein interactions with chromatin and epigenetic changes such as acetylation and methylation throughout the genome of different organisms. This technique has revolutionised our understanding of molecular genomics, continues to be widely used and is currently being applied in novel areas of cancer research. Read More

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August 2013
3 Reads

Recent advances in gene therapy of endometriosis.

Recent Pat DNA Gene Seq 2013 Dec;7(3):169-78

Ott's Institute for Obstetrics and Gynecology RAMS Saint-Petersburg Russia, 199034 Mendeleevskaya line, 3.

Endometriosis is a gynecological disease that affects up to 10%-15% of all reproductive-age women worldwide. It is characterized by the presence of endometrial tissues outside the uterine cavity. Endometriosis is a complex disease; its pathogenesis includes altered steroid metabolism and immune system abnormalities such as inflammation, increased angiogenic activity in the peritoneal fluid and impaired recognition of ectopic endometrial cells. Read More

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December 2013
23 Reads

Biotechnological advances in amaranths species and their future outlook in crop improvement--a review.

Authors:
R M Pandey

Recent Pat DNA Gene Seq 2013 Dec;7(3):179-86

Division of Genetics, Plant Breeding & Agrotechnology, National Botanical Research Institute, Lucknow-226001, India.

The grain amaranths were important food crops for the ancient middle and South American civilization. The germplasm of amaranths also has not been well characterized from the point of view of its exploitation for improvement of amaranths in general, a grain amaranth in particular. Among all under exploited crops grain amaranth is the most suitable candidate to begin with. Read More

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December 2013
3 Reads

Patent landscape for biological hydrogen production.

Recent Pat DNA Gene Seq 2013 Dec;7(3):207-13

Department of Biosystems Engineering, E2-376 EITC, University of Manitoba, Winnipeg, Manitoba, Canada, R3T 5V6.

Research and development of biological hydrogen production have expanded significantly in the past decade. Production of renewable hydrogen from agricultural, forestry, or other organic waste streams offers the possibility to contribute to hydrogen production capacity with no net, or at least with lower, greenhouse gas emissions. Significant improvements in the volumetric or molar yields of hydrogen production have been accomplished through genetic engineering of hydrogen synthesizing microorganisms. Read More

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December 2013
9 Reads

Patented aptamers for C-reactive protein detection: a review about their use in clinical diagnostics.

Recent Pat DNA Gene Seq 2013 Dec;7(3):195-206

Department of Physiology, University Center of Health Sciences (CUCS)-University of Guadalajara, Jalisco, Mexico.

C-reactive protein (CRP) is a homopentameric oligoprotein composed of monomeric subunits that are about 21 kD each. The form of detectable native CRP in validated assays was developed in 2007 and from that time has been considered as an excellent biomarker for peripheral artery disease and/or atherosclerosis, as well as a cardiovascular disease marker for risk prediction. The improvements in the detection of CRP levels could predict significantly the population that have increased risk of stroke being the modulation of CRP levels as a therapeutical outcome for prevention of cardiovascular diseases. Read More

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December 2013
22 Reads

Editorial: recent advances on molecular improvement of bio-energy plants.

Authors:
Shu-Ye Jiang

Recent Pat DNA Gene Seq 2013 Apr;7(1)

Temasek Life Sciences Laboratory, 1 Research Link, the National University of Singapore, Singapore 117604.

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April 2013
2 Reads

Generation of sequence variants via accelerated molecular evolution methods.

Recent Pat DNA Gene Seq 2013 Aug;7(2):144-56

MOE Key Laboratory of Aquatic Product Safety, State Key Laboratory of Biocontrol, Biotechnology Research Center, The School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.

Directed evolution shortcuts million-year-scale natural evolution in a matter of weeks and generates tens of millions of sequence variants in a single test tube. A team of researchers used random DNA flanked by homologous sequences for in vivo homologous recombination, known as multiplex automated genome engineering (MAGE) to select the most active gene variants. They also adopted this approach to replace hundreds of stop codons in the E. Read More

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August 2013
12 Reads

Patented biotechnological applications of serpin: an update.

Recent Pat DNA Gene Seq 2013 Aug;7(2):137-43

INRA, UMR1319 Micalis Domaine de Vilvert, F-78350 Jouy-en-Josas.

The Serine Protease Inhibitors (Serpins) have been a focus of research by biomedical industries due to their critical role in human health. The use of serpin in the treatment of many diseases was widely investigated through the identification of new genes encoding these proteins in all kingdoms of life. The characterization of these genes revealed that they encoded proteins having low sequence homologies. Read More

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August 2013
4 Reads

Functional genomics of bio-energy plants and related patent activities.

Recent Pat DNA Gene Seq 2013 Apr;7(1):45-56

Temasek Life Sciences Laboratory, 1 Research Link, the National University of Singapore, Singapore 117604.

With dwindling fossil oil resources and increased economic growth of many developing countries due to globalization, energy driven from an alternative source such as bio-energy in a sustainable fashion is the need of the hour. However, production of energy from biological source is relatively expensive due to low starch and sugar contents of bioenergy plants leading to lower oil yield and reduced quality along with lower conversion efficiency of feedstock. In this context genetic improvement of bio-energy plants offers a viable solution. Read More

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April 2013
2 Reads

Editorial: Genetics And Athletics.

Authors:
Dov Greenbaum

Recent Pat DNA Gene Seq 2012 Dec;6(3):173-4

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December 2012
1 Read

Recent patents concerning modulators of protein kinase C.

Recent Pat DNA Gene Seq 2013 Apr;7(1):74-81

Department of Nursing, Catholic University of Murcia (UCAM), 30107, Murcia, Spain.

Protein kinase C (PKC) comprises a family of 10 serine/threonine kinases divided into 3 subfamilies: classical, novel and atypical. These isoenzymes represent one of the major mediators of signal transduction, and most may be associated with several pathogenic processes including malignant transformation or cancer and metastasis. Moreover, some activated isoenzymes are also involved in other diseases such as infarct, rejection due to incomplete histocompatibility in organ transplantation, pain, diabetic macular edema, etc. Read More

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April 2013
2 Reads

Foreword.

Authors:
Mourad Elloumi

Recent Pat DNA Gene Seq 2012 Sep 14. Epub 2012 Sep 14.

Laboratory of Technologies of Information and Communication, Electrical Engineering (LaTICE), University of Tunis-El Manar, Tunisia.

Pattern finding in biomolecular data is at the core of Computational Molecular Biology research. Indeed, it makes a very important contribution in the analysis of these data. It can reveal information about shared biological functions of biological macromolecules, coming from several different organisms, by the identification of patterns that are shared by structures related to these macromolecules. Read More

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September 2012
2 Reads

Negative information for building phylogenies.

Recent Pat DNA Gene Seq 2013 Aug;7(2):128-36

Department of Informatics, King's College London, London WC2R 2LS, United Kingdom.

An absent word (also called a forbidden word or an unword in other contexts) in a sequence is a segment that does not appear in the given sequence. It is a minimal absent word if all its proper factors occur in the given sequence. In this article, we review the concept of minimal absent words, which includes the notion of shortest absent words but is much stronger. Read More

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August 2013
4 Reads

Extraction of infrequent simple motifs from a finite set of sequences using a lattice structure.

Recent Pat DNA Gene Seq 2013 Aug;7(2):123-7

Laboratory of Technologies of Information and Communication and Electrical Engineering, Higher School of Sciences and Technologies of Tunis, 1008 Tunis, Tunisia.

In this paper we present a method for finding infrequent simple motifs in a finite set of sequences. The method uses a lattice structure and minimal forbidden patterns. It is based on a method for solving the Simple Motif Problem and has the potential to discover new patents in biological macromolecules. Read More

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August 2013
8 Reads

A computational approach to finding RNA tertiary motifs in genomic sequences: a case study.

Recent Pat DNA Gene Seq 2013 Aug;7(2):115-22

Bioinformatics Program and Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey 07102, USA.

Motif finding in DNA, RNA and proteins plays an important role in life science research. Recent patents concerning motif finding in biomolecular data are recorded in the DNA Patent Database which serves as a resource for policy makers and members of the general public interested in fields like genomics, genetics and biotechnology. In this paper, we present a computational approach to mining for RNA tertiary motifs in genomic sequences. Read More

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August 2013
4 Reads
1 Citation

Genetic algorithms with permutation coding for multiple sequence alignment.

Recent Pat DNA Gene Seq 2013 Aug;7(2):105-14

Qassim University, College of Computer, Saudi Arabia.

Multiple sequence alignment (MSA) is one of the topics of bio informatics that has seriously been researched. It is known as NP-complete problem. It is also considered as one of the most important and daunting tasks in computational biology. Read More

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August 2013
4 Reads

Pattern matching in indeterminate and Arc-annotated sequences.

Recent Pat DNA Gene Seq 2013 Aug;7(2):96-104

A l EDA Group, Department of CSE, BUET, Dhaka-1000, Bangladesh.

In this paper, we present efficient algorithms for finding indeterminate Arc-Annotated patterns in indeterminate Arc-Annotated references. Our algorithms run in O(m+ (nm) w) time where n and m are respectively the length of our reference and pattern strings and w is the target machine word size. Here we have assumed the alphabet size to be constant, because, indeterminate Arc-Annotated sequences are used to model biological sequences. Read More

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August 2013
2 Reads

GapMis: a tool for pairwise sequence alignment with a single gap.

Recent Pat DNA Gene Seq 2013 Aug;7(2):84-95

Czech Technical University in Prague, Dept. of Theoretical Computer Science, Czech Republic.

Motivation: Pairwise sequence alignment has received a new motivation due to the advent of recent patents in next-generation sequencing technologies, particularly so for the application of re-sequencing---the assembly of a genome directed by a reference sequence. After the fast alignment between a factor of the reference sequence and a high-quality fragment of a short read by a short-read alignment programme, an important problem is to find the alignment between a relatively short succeeding factor of the reference sequence and the remaining low-quality part of the read allowing a number of mismatches and the insertion of a single gap in the alignment.

Results: We present GapMis, a tool for pairwise sequence alignment with a single gap. Read More

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August 2013
5 Reads

Recent patents on bacteriocins: food and biomedical applications.

Recent Pat DNA Gene Seq 2013 Apr;7(1):66-73

Laboratory of Applied Microbiology, Department of Biology, Faculty of Sciences, Oran University, B.P. 16, Es-Senia, Oran, 31100 Algeria.

Most types of bacteria produce bacteriocins, which are proteinaceous extracellular compounds that can inhibit the growth of other undesirable microorganisms. Bacteriocins are receiving increasing attention, due to their many applications, ranging from their initial application in strategies for food preservation to more recent proposed uses in biomedical strategies aimed at fighting certain bacterial infections. Thus, while nisin has a long history of use as a safe additive in certain food products for the purpose of food preservation, certain bacteriocin-producing lactic acid bacteria, which are generally recognised as safe microorganisms, or their extracellular extracts are receiving increased attention as protective cultures or antimicrobial extracts in minimally processed food products. Read More

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April 2013
10 Reads

Editorial : recent strategies in gene delivery.

Authors:
Xian Jun Loh

Recent Pat DNA Gene Seq 2012 Aug;6(2):81

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August 2012
11 Reads

Horses for courses: a DNA-based test for race distance aptitude in thoroughbred racehorses.

Recent Pat DNA Gene Seq 2012 Dec;6(3):203-8

UCD School of Agriculture and Food Science, University College Dublin, Belfield, Dublin, Ireland.

Variation at the myostatin (MSTN) gene locus has been shown to influence racing phenotypes in Thoroughbred horses, and in particular, early skeletal muscle development and the aptitude for racing at short distances. Specifically, a single nucleotide polymorphism (SNP) in the first intron of MSTN (g.66493737C/T) is highly predictive of best race distance among Flat racing Thoroughbreds: homozygous C/C horses are best suited to short distance races, heterozygous C/T horses are best suited to middle distance races, and homozygous T/T horses are best suited to longer distance races. Read More

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December 2012
12 Reads

Genetic privacy in sports: clearing the hurdles.

Recent Pat DNA Gene Seq 2012 Dec;6(3):224-8

Department of Clinical Research and Leadership, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA.

As genomic medicine continues to advance and inform clinical care, knowledge gained is likely to influence sports medicine and training practices. Susceptibility to injury, sudden cardiac failure, and other serious conditions may one day be tackled on a subclinical level through genetic testing programs. In addition, athletes may increasingly consider using genetic testing services to maximize their performance potential. Read More

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December 2012
3 Reads

Genetic enhancement in sport: just another form of doping?

Recent Pat DNA Gene Seq 2012 Dec;6(3):240-6

The Law-Medicine Center, Case Western Reserve University School of Law.

Patented genetic technologies such as the ACTN3 genetic test are adding a new dimension to the types of performance enhancement available to elite athletes. Organized sports organizations and governments are seeking to prevent athletes' use of biomedical enhancements. This paper discusses how these interdiction efforts will affect the use and availability of genetic technologies that can enhance athletic performance. Read More

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December 2012
4 Reads

Genetics & sport: bioethical concerns.

Authors:
Andy Miah

Recent Pat DNA Gene Seq 2012 Dec;6(3):197-202

University of the West of Scotland.

This paper provides an overview of the ethical issues pertaining to the use of genetic insights and techniques in sport. Initially, it considers a range of scientific findings that have stimulated debate about the ethical issues associated with genetics applied to sport. It also outlines some of the early policy responses to these discoveries from world leading sports organizations, along with knowledge about actual use of gene technologies in sport. Read More

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December 2012
5 Reads

Predictive genomics DNA profiling for athletic performance.

Recent Pat DNA Gene Seq 2012 Dec;6(3):229-39

Shafallah Medical Genetics Center, Doha, Qatar.

Genes control biological processes such as muscle, cartilage and bone formation, muscle energy production and metabolism (mitochondriogenesis, lactic acid removal), blood and tissue oxygenation (erythropoiesis, angiogenesis, vasodilatation), all essential in sport and athletic performance. DNA sequence variations in such genes confer genetic advantages that can be exploited, or genetic 'barriers' that could be overcome to achieve optimal athletic performance. Predictive Genomic DNA Profiling for athletic performance reveals genetic variations that may be associated with better suitability for endurance, strength and speed sports, vulnerability to sports-related injuries and individualized nutritional requirements. Read More

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December 2012
21 Reads

Genetic determinants of athletic performance.

Recent Pat DNA Gene Seq 2012 Dec;6(3):175-9

Silicon Valley Biosystems, Navigenics, Menlo Park, CA 95026, USA.

An extraordinary revolution in medical research has taken place over the past decade, enabled by the completion of the first human genome sequence in 2001. The Human Genome Project (HGP) has resulted in the 6 billion letter reference human genome sequence and the ultra-high throughput technologies used by medical researchers to identify correlations between positions within the human genome (genotypes) and diseases or traits (phenotypes). Just as every human disease has a genetic component, so too does every human trait. Read More

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December 2012
20 Reads

Prometheus: the Supreme Court redefines the patentability of diagnostic inventions.

Recent Pat DNA Gene Seq 2012 Dec;6(3):193-6

HelixIP LLP, Redwood City, CA 94063, USA.

The United States Supreme Court recently issued an opinion regarding the patentability of claims directed to diagnostic methods in Mayo Collab. Service v. Prometheus Lab. Read More

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December 2012
2 Reads

Critical overview of applications of genetic testing in sport talent identification.

Authors:
Stephen M Roth

Recent Pat DNA Gene Seq 2012 Dec;6(3):247-55

Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD 20742, USA.

Talent identification for future sport performance is of paramount interest for many groups given the challenges of finding and costs of training potential elite athletes. Because genetic factors have been implicated in many performance- related traits (strength, endurance, etc.), a natural inclination is to consider the addition of genetic testing to talent identification programs. Read More

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December 2012
9 Reads

Personal genetics: sports utility vehicle?

Recent Pat DNA Gene Seq 2012 Dec;6(3):209-15

Biomedical Engineering Laboratory, Institute of Communication and Computer Systems, National Technical University of Athens, Athens, Greece.

Personal genetic testing which is not strictly related to medicine or health is becoming more and more popular covering areas from ancestry, genealogy, nutrition& lifestyle and more recently sports and exercise. The reasons are compelling - if it were possible to read in our genes our potential sporting attributes and how to achieve them it would be valuable information. But is it possible? This overview will look at the current situation and future prospects the authors believe that there is utility in sports genetic testing exactly what can be interpreted from our genetic results needs to be precisely defined and limited to what has been demonstrated by repeated scientific studies. Read More

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December 2012
10 Reads

Recent patents on genetic modification of plants and microbes for biomass conversion to biofuels.

Recent Pat DNA Gene Seq 2013 Apr;7(1):25-35

Department Bioresource Policy, Business and Economics, 51 Campus Drive, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5A8, Canada.

Development of sustainable energy systems based on renewable biomass feedstocks is now a global effort. Lignocellulosic biomass contains polymers of cellulose, hemicellulose, and lignin, bound together in a complex structure. Liquid biofuels, such as ethanol, can be made from biomass via fermentation of sugars derived from the cellulose and hemicellulose within lignocellulosic materials, but pre-treatment of the biomass to release sugars for microbial conversion is a significant barrier to commercial success of lignocellulosic biofuel production. Read More

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April 2013
6 Reads

Genetic improvement of plants for enhanced bio-ethanol production.

Recent Pat DNA Gene Seq 2013 Apr;7(1):36-44

City Colleges of Chicago, Harold Washington College, Department of Biology, 30 E Lake St, Chicago, IL 60610, USA.

The present world energy situation urgently requires exploring and developing alternate, sustainable sources for fuel. Biofuels have proven to be an effective energy source but more needs to be produced to meet energy goals. Whereas first generation biofuels derived from mainly corn and sugarcane continue to be used and produced, the contentious debate between "feedstock versus foodstock" continues. Read More

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April 2013
5 Reads

Development of energy plants and their potential to withstand various extreme environments.

Recent Pat DNA Gene Seq 2013 Apr;7(1):13-24

Plant Protection and Improvement Laboratory, Centre of Biotechnology of Sfax [CBS], B.P'1177', 3018 Sfax, Tunisia.

Biomass utilization is increasingly considered as a practical way for sustainable energy supply and long-term environment care around the world. In concerns with food security, starch or sugar-based bioethanol and edible-oilderived biodiesel are severely restricted for large scale production. Alternatively, conversion of lignocellulosic residues from food crops could be considered, but due to its recalcitrance, the current biomass process is unacceptably expensive. Read More

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April 2013
3 Reads

Genetic improvement of biofuel plants: recent progress and patents.

Recent Pat DNA Gene Seq 2013 Apr;7(1):2-12

Natural Remedies Pvt. Ltd, Plot No. 5B, Veerasandra Industrial Area, 19th K. M. Stone, Electronic City (Post), Hosur Road, Bangalore-560 100. India.

Due to depleting reserves of fossil fuels, political uncertainties, increase in demand of energy needs and growing concerns of environmental effects, bioenergy as an alternative source of energy needs had taken centre stage globally. In this report, we review the progress made in lignocellulose, cellulose and fermentation based biofuels in addition to tree borne oil seeds. Algae as a source of feedstock for the biofuel has also been reviewed. Read More

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April 2013
6 Reads

Application of genomics in the prevention, treatment and management of Achilles tendinopathy and anterior cruciate ligament ruptures.

Recent Pat DNA Gene Seq 2012 Dec;6(3):216-23

UCT/MRC Research Unit for Exercise Science and Sports Medicine of the Department of Human Biology, University of Cape Town, South Africa.

Musculoskeletal soft tissue injuries such as Achilles tendinopathy and anterior cruciate ligament ruptures are common among elite athletes, recreational athletes and physically active individuals. The consequences of injury may be devastating and prevent the recreational or competitive athlete from reaching their potential or lead to a premature end to their careers. Although these injuries have been well described at a clinical level, the biological mechanisms causing these injuries are poorly understood. Read More

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December 2012
2 Reads

From sweaty towels to genetic stats: stalking athletes for their genetic information.

Authors:
Sonia M Suter

Recent Pat DNA Gene Seq 2012 Dec;6(3):189-92

George Washington University, USA.

With recent advances in genetics, sports fans may soon have access to a new category of statistics: genetic information. With patented correlations between genetics and athletics, and with the emergence of a growing and unregulated market in direct-to-consumer ("DTC") genetic testing, fans may be able to obtain an athlete's genetic information on their own, as long as they can access any item that may have some DNA on it. In some jurisdictions, they may even be able to do so legally, notwithstanding the potential harms to the athletes and their privacy. Read More

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December 2012
2 Reads

On sports and genes.

Recent Pat DNA Gene Seq 2012 Dec;6(3):180-8

Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.

Our genes influence our athletic ability. However, the causal genetic factors and mechanisms, and the extent of their effects, remain largely elusive. Many studies investigate this association between specific genes and athletic performance. Read More

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December 2012
3 Reads

Gene delivery by functional inorganic nanocarriers.

Recent Pat DNA Gene Seq 2012 Aug;6(2):108-14

Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

Gene delivery into cells to elicit cellular response has received a great attention recently. Viruses, lipids, peptides, cationic polymers and certain inorganic nanomaterials have been reported as gene delivery vectors. In this review, we focus on the recent literature on gene delivery using inorganic nanoparticles. Read More

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August 2012
7 Reads

Polymers for gene delivery: current status and future perspectives.

Recent Pat DNA Gene Seq 2012 Aug;6(2):98-107

Biosurface Technology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.

Gene therapy is a hope for curing many diseases and pathological conditions which are relatively difficult to treat. However lack of proper gene delivery vehicle is the main limiting step in this direction. Though viral vectors still lead as the major vehicle used in gene therapy clinical trials, their immunogenicity and low capacity restrict their wide use. Read More

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August 2012
2 Reads

Recent patents in siRNA delivery employing nanoparticles as delivery vectors.

Authors:
Surendra Nimesh

Recent Pat DNA Gene Seq 2012 Aug;6(2):91-7

Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada.

Small interfering RNAs (siRNAs) are rapidly emerging as new therapeutic tools for the treatment of some of the deadly diseases such as cancer. However, poor cellular uptake and instability in physiological milieu limit its therapeutic potential, hence there arises a need of a delivery system which can efficiently and repeatedly deliver siRNA to the target cells. Nanoparticles have shown immense potential as suitable delivery vectors with enhanced efficacy and biocompatibility. Read More

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August 2012
3 Reads

Advances in lentiviral vectors: a patent review.

Recent Pat DNA Gene Seq 2012 Aug;6(2):82-90

Center for Cell Therapy and Regional Blood Center; National Institute of Science and Technology in Stem Cell Therapy; Ribeirao Preto, Brazil.

Lentiviral vectors are at the forefront of gene delivery systems for research and clinical applications. These vectors have the ability to efficiently transduce nondividing and dividing cells, to insert large genetic segment in the host chromatin, and to sustain stable long-term transgene expression. Most of lentiviral vectors systems in use are derived from HIV-1. Read More

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August 2012
4 Reads

Breaking the bond: recent patents on bacterial adhesins.

Recent Pat DNA Gene Seq 2012 Aug;6(2):160-71

Centro de Biotecnologia, Instituto Butantan, Brazil.

Adhesins need to be exposed on the surface of pathogenic bacteria to properly interact with host tissues and allow establishment of the infection. This fact implies that, in theory, one could manage or avoid infection by controlling adhesins' function, and also by indirectly detecting bacteria through their surface-exposed adhesins. Besides, binding of anti-adhesin immunoglobulins on the bacterial surface tend to promote the opsonization of the pathogen. Read More

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August 2012
3 Reads

Evaluation of Brazilian biotechnology patent activity from 1975 to 2010.

Recent Pat DNA Gene Seq 2012 Aug;6(2):145-59

Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

The analysis of patent activity is one methodology used for technological monitoring. In this paper, the activity of biotechnology-related patents in Brazil were analyzed through 30 International Patent Classification (IPC) codes published by the Organization for Economic Cooperation and Development (OECD). We developed a program to analyse the dynamics of the major patent applicants, countries and IPC codes extracted from the Brazilian Patent Office (INPI) database. Read More

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August 2012
2 Reads

Patents in the era of genomics: an overview.

Recent Pat DNA Gene Seq 2012 Aug;6(2):127-44

Department of Biotechnology, D.D.U Gorakhpur University, Gorakhpur (U.P.) 273 009 India.

The recent developments in biotechnology are the emerging science of "omics"- genomics, proteomics, transcriptomics and metabolomics. The state of the art sequencing technology has led to the deciphering of whole genome sequences of various microbes, plant, human and animals. The outcomes of genomics in the form of various genes, gene fragments, single nucleotide polymorphism, promoters and other regulatory sequences are a subject matter for patents based on its applications spanning agricultural, biomedical and industrial sectors. Read More

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August 2012
1 Read

Licensed DNA Vaccines against Infectious Hematopoietic Necrosis Virus (IHNV).

Recent Pat DNA Gene Seq 2013 Apr;7(1):62-5

Department of Animal Health, Basque Institute for Agricultural Research and Development, Neiker-Tecnalia, Technological Park of Bizkaia, Berreaga 1, Derio, Bizkaia, Spain 48160.

This article reviews some of the recent patents on DNA vaccines against fish viruses, in particular against the novirhabdovirus infectious hematopoitic necrosis virus (IHNV). Although very effective in protecting fish against IHNV, only one DNA vaccine has been approved to date for use in Canada. In Europe and in US, its commercialization is restricted due to safety concerns. Read More

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April 2013
5 Reads

Recent patents on high-throughput single nucleotide polymorphism (SNP) genotyping methods.

Recent Pat DNA Gene Seq 2012 Aug;6(2):122-6

Federal University of Espirito Santo, CCA - Alegre, Espirito Santo, Brazil.

Single nucleotide polymorphisms (SNPs) are single-base inheritable variations in a given and defined genetic location that occur in at least 1% of the population. SNPs are useful markers for genetic association studies in disease susceptibility or adverse drug reactions, in evolutionary studies and forensic science. Given the potential impact of SNPs, the biotechnology industry has focused on the development of high-throughput methods for SNP genotyping. Read More

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August 2012
3 Reads

Advances in the management of malignant hemopathies: the role of statins.

Recent Pat DNA Gene Seq 2013 Apr;7(1):57-61

Clinica Medicala II, Spitalul Clinic Judetean, B-dul Corneliu Coposu, Nr 2-4, 2400 Sibiu, Romania.

Today, hematology is dependent on molecular biology for diagnosis, establishing the prognosis and treatment guidance in more and more diseases. One useful technique in this respect is the gene expression profiling, whose use is not yet a matter of routine. The discovery that the expression of LDL-receptor and cholesterol synthesis is increased in the cells of some leukemias and lymphomas and that some statins induced DNA damages and increased the level of reactive oxygen species, opens the possibility of using statins in the treatment of certain malignant hemopathies. Read More

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April 2013
2 Reads

Mini-review: spinocerebellar ataxias: an update of SCA genes.

Recent Pat DNA Gene Seq 2012 Aug;6(2):115-21

Laboratory of Molecular Aspects Associated to Genetic Diseases, University of Western Santa Catarina, UNOESC-SC/ Brazil.

Autosomal dominant spinocerebellar ataxias (SCAs) are a complex group of debilitating and neurodegenerative diseases that affect the cerebellum and its main connections and characterized by a generalized incoordination of gait, speech, and limb movements. In general, the onset of SCAs occurs during adult life and shows great clinical heterogeneity. Currently, the mutations responsible for different types of SCAs have been localized in different regions of the genome, and most of them were already mapped and cloned. Read More

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August 2012
5 Reads

Molecular cloning of a novel PPEF-1 gene variant from a T-cell lymphoblastic lymphoma cell line.

Recent Pat DNA Gene Seq 2012 Apr;6(1):72-7

Division of General Surgery, Buddhist Tzu Chi General Hospital, Taipei Branch, Taiwan.

To determine if there is a gene variant of protein serine-threonine phosphatase with EF hand (PPEF-1) in T-cell lymphoblastic lymphoma SUP-T1 cell line, both in silico and in vitro approaches were conducted. In silico, a cDNA clone showing similar sequence to PPEF-1 was isolated from the SUP-T1 cDNA library and named PPEF-1V. The full-length of the PPEF-1V cDNA clone is a 2135bp containing a 1503bp open reading frame extending from 188bp to 1690bp, which corresponds to an encoded protein of 501 amino acid residues with a predicted molecular mass of 57. Read More

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April 2012
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Insight into p95HER2 in breast cancer: molecular mechanisms and targeted therapies.

Recent Pat DNA Gene Seq 2012 Apr;6(1):56-63

Department of Medical Oncology, Portuguese Oncology Institute, Rua Dr. António Bernardino de Almeida, 4200-079, Porto, Portugal.

Breast cancer afflicts more than 1.3 million people worldwide and is the main cause of cancer-related deaths among women. Many efforts are underway to develop new therapeutic and biomarker strategies for the management of this disease. Read More

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April 2012
12 Reads
5 Citations