1,009,736 results match your criteria Recent Patents on Chemical Engineering [Journal]


Legal and ethical implications of defining an optimum means of achieving unconsciousness in assisted dying.

Anaesthesia 2019 Feb 20. Epub 2019 Feb 20.

Nuffield Department of Anaesthetics, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

A decision by a society to sanction assisted dying in any form should logically go hand-in-hand with defining the acceptable method(s). Assisted dying is legal in several countries and we have reviewed the methods commonly used, contrasting these with an analysis of capital punishment in the USA. We expected that, since a common humane aim is to achieve unconsciousness at the point of death, which then occurs rapidly without pain or distress, there might be a single technique being used. Read More

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http://dx.doi.org/10.1111/anae.14532DOI Listing
February 2019

Continuous intracerebroventricular injection of Porphyromonas gingivalis lipopolysaccharide induces systemic organ dysfunction in a mouse model of Alzheimer's disease.

Exp Gerontol 2019 Feb 17. Epub 2019 Feb 17.

Department of Pharmacology and Molecular Therapeutics, Graduate School of Medical Sciences, Kumamoto University, Japan.

Systemic organ dysfunction is one of the important issues for the patients with Alzheimer's disease (AD) and their caregivers. Recent evidences suggest that periodontitis is a possible risk factor for progression of AD and lipopolysaccharide derived from Porphyromonas gingivalis (Pg-LPS) which is a major periodontopathic bacteria induces cognitive impairment in mice. However, the precise relationships between the brain exposure of Pg-LPS and systemic organ dysfunction in AD patients are still undetermined. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.007DOI Listing
February 2019

A Molecular View of Plant Local Adaptation: Incorporating Stress-Response Networks.

Annu Rev Plant Biol 2019 Feb 20. Epub 2019 Feb 20.

Department of Plant Biology, Michigan State University, East Lansing, Michigan 48824, USA; email:

Ecological specialization in plants occurs primarily through local adaptation to different environments. Local adaptation is widely thought to result in costly fitness trade-offs that result in maladaptation to alternative environments. However, recent studies suggest that such trade-offs are not universal. Read More

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http://dx.doi.org/10.1146/annurev-arplant-050718-100114DOI Listing
February 2019

Mammalian Respiratory Complex I Through the Lens of Cryo-EM.

Annu Rev Biophys 2019 Feb 20. Epub 2019 Feb 20.

Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, United Kingdom; email: , , ,

Single-particle electron cryomicroscopy (cryo-EM) has led to a revolution in structural work on mammalian respiratory complex I. Complex I (mitochondrial NADH:ubiquinone oxidoreductase), a membrane-bound redox-driven proton pump, is one of the largest and most complicated enzymes in the mammalian cell. Rapid progress, following the first 5-Å resolution data on bovine complex I in 2014, has led to a model for mouse complex I at 3. Read More

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http://dx.doi.org/10.1146/annurev-biophys-052118-115704DOI Listing
February 2019

Membrane Electroporation and Electropermeabilization: Mechanisms and Models.

Annu Rev Biophys 2019 Feb 20. Epub 2019 Feb 20.

Faculty of Electrical Engineering, University of Ljubljana , SI-1000 Ljubljana, Slovenia; email: ,

Exposure of biological cells to high-voltage, short-duration electric pulses causes a transient increase in their plasma membrane permeability, allowing transmembrane transport of otherwise impermeant molecules. In recent years, large steps were made in the understanding of underlying events. Formation of aqueous pores in the lipid bilayer is now a widely recognized mechanism, but evidence is growing that changes to individual membrane lipids and proteins also contribute, substantiating the need for terminological distinction between electroporation and electropermeabilization. Read More

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http://dx.doi.org/10.1146/annurev-biophys-052118-115451DOI Listing
February 2019

International Divergence in Gene Patenting.

Annu Rev Genomics Hum Genet 2019 Feb 20. Epub 2019 Feb 20.

Centre for IT and IP Law, KU Leuven, 3000 Leuven, Belgium.

This review explores the recent divergence in international patent law relating to the patenting of genes and related subject matter. This divergence stems primarily from decisions of the highest courts in the United States and Australia on the eligibility of patent claims relating to the BRCA gene sequences. Patent offices, courts, and policy makers have struggled for many years to clearly articulate the bounds of patent claims on isolated and synthetic DNA and related products and processes, including methods for their use in genetic diagnostics. Read More

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http://dx.doi.org/10.1146/annurev-genom-083118-015112DOI Listing
February 2019

Kinetics of Drug Binding and Residence Time.

Annu Rev Phys Chem 2019 Feb 20. Epub 2019 Feb 20.

Department of Pharmacy and Biotechnology, University of Bologna, I-40126 Bologna, Italy; email:

The kinetics of drug binding and unbinding is assuming an increasingly crucial role in the long, costly process of bringing a new medicine to patients. For example, the time a drug spends in contact with its biological target is known as residence time (the inverse of the kinetic constant of the drug-target unbinding, 1/ k). Recent reports suggest that residence time could predict drug efficacy in vivo, perhaps even more effectively than conventional thermodynamic parameters (free energy, enthalpy, entropy). Read More

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http://dx.doi.org/10.1146/annurev-physchem-042018-052340DOI Listing
February 2019

DUckCov: a Dynamic Undocking-based Virtual Screening Protocol for Covalent Binders.

ChemMedChem 2019 Feb 20. Epub 2019 Feb 20.

Research Center for Natural Sciences, Medicinal Chemistry, Magyar tudosok krt 2, H-1117, Budapest, HUNGARY.

Thanks to recent guidelines, the design of safe and effective covalent drugs has gained significant interest. Other than targeting non-conserved nucleophilic residues, optimizing the non-covalent binding framework is important to improve potency and selectivity of covalent binders towards the desired target. Strong efforts have been made in extending the computational toolkits to include a covalent mechanism of protein targeting, like in the development of covalent docking methods for binding mode prediction. Read More

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http://dx.doi.org/10.1002/cmdc.201900078DOI Listing
February 2019

Design of CK2β-mimicking peptides as tools to study the CK2α/CK2β interaction in cancer cells.

ChemMedChem 2019 Feb 20. Epub 2019 Feb 20.

University of Cologne, Department of Pharmacology, Gleueler Strasse 24, 50931, Cologne, GERMANY.

The ubiquitously expressed Ser/Thr kinase CK2 is a key regulator in a variety of key processes in normal and malignant cells. Due to its distinctive anti-apoptotic and tumor-driving properties, elevated levels of CK2 have frequently been found in tumors of different origin. In recent years, development of CK2 inhibitors has largely been focused on ATP-competitive compounds; however, targeting the CK2α/CK2β interface has emerged as a further concept that might avoid selectivity issues. Read More

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http://dx.doi.org/10.1002/cmdc.201800786DOI Listing
February 2019

Drug Discovery for Pemphigoid Diseases.

Curr Protoc Pharmacol 2019 Feb 20:e55. Epub 2019 Feb 20.

Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

Pemphigoid diseases (PDs) are a group of autoimmune bullous diseases characterized and caused by autoantibodies targeting structural proteins of the skin and mucous membranes. Chronic inflammation, subepidermal blistering, and often scaring are the clinical characteristics of PDs. Itching and, in severe cases, disabilities resulting from scaring (i. Read More

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http://dx.doi.org/10.1002/cpph.55DOI Listing
February 2019

Recent Advances of MOF-Derived Nanoporous Carbon Materials.

Chem Asian J 2019 Feb 20. Epub 2019 Feb 20.

Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia, AUSTRALIA.

Metal-organic frameworks (MOFs)-derived nanoporous carbon materials have received significant interest due to their advantages of controllable porosity, good thermal/chemical stability, high electrical conductivity, catalytic activity, easy modification with other elements and materials, etc. Thus, MOF-derived carbons have been used in numerous applications such as environment, energy storage systems (i.e. Read More

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http://doi.wiley.com/10.1002/asia.201900026
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http://dx.doi.org/10.1002/asia.201900026DOI Listing
February 2019
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Progress toward Understanding the Interactions between DNA Nanostructures and the Cell.

Small 2019 Feb 20:e1805416. Epub 2019 Feb 20.

Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

Advances in DNA nanotechnology empower the programmable assembly of DNA building blocks (oligonucleotides and plasmids) into DNA nanostructures with precise architectural control. As DNA nanostructures are biocompatible and can naturally enter mammalian cells without the aid of transfection agents, they have found numerous biological or biomedical applications as delivery carriers of therapeutic and imaging cargoes into mammalian cells for at least a decade. Nevertheless, mechanistic studies on how DNA nanostructures interact with cells have remained limited and incomprehensive until 2-3 years ago. Read More

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http://dx.doi.org/10.1002/smll.201805416DOI Listing
February 2019

The nationwide epidemiologic survey of Kawasaki disease in Japan, 2015-2016.

Pediatr Int 2019 Feb 20. Epub 2019 Feb 20.

Department of Public Health, Jichi Medical University, Shimotsuke, Japan.

Background: Approximately 50 years have passed since Kawasaki disease (KD) was first reported. The Kawasaki disease nationwide survey began in 1970. Although more than 360,000 patients have already been reported in Japan, the cause is still unknown. Read More

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http://dx.doi.org/10.1111/ped.13809DOI Listing
February 2019

Blastemal Predominant Type Wilms Tumors in Japan: Japan Children's Cancer Group.

Pediatr Int 2019 Feb 20. Epub 2019 Feb 20.

Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan.

Background: Persistence of blastemal components after chemotherapy is a marker of poor outcome in Wilms tumor. Recent reports from local Japanese areas have described prechemotherapy blastemal predominant type Wilms tumor to be also a risk factor for relapse. However, significance of blastemal predominant WT remains to be evaluated in a larger study. Read More

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http://dx.doi.org/10.1111/ped.13811DOI Listing
February 2019

Bed Bath with Soap and Water or Disposable Wet Wipes: Patients' Experiences and Preferences.

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.

Aims And Objectives: To gain an in-depth understanding of patients' preferences regarding two bed bath methods: soap and water and disposable wet wipes.

Background: Bed baths allow hospitalized, bedridden patients to stay clean and fresh. They serve a number of purposes: health promotion, social propriety and pure pleasure. Read More

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http://dx.doi.org/10.1111/jocn.14825DOI Listing
February 2019

Recent drought and tree mortality effects on the avian community in southern Sierra Nevada: a glimpse of the future?

Ecol Appl 2019 Feb 20:e01848. Epub 2019 Feb 20.

Point Blue Conservation Science, 3820 Cypress Drive, #11, Petaluma, California, 94954, USA.

Birds respond rapidly to changes in both habitat and climate conditions and thus are good indicators of the ecological effects of a changing climate, which may include warmer temperatures, changing habitat conditions, and increased frequency and magnitude of extreme events like drought. We investigated how a widespread tree mortality event concurrent with a severe drought influenced the avian community of the Sierra Nevada mountain range in California. We assessed and compared the separate effects of climate stresses and altered habitat conditions on the avian community and used this information to evaluate the changes that are likely to occur in the near future. Read More

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http://dx.doi.org/10.1002/eap.1848DOI Listing
February 2019

Reevaluating the initial impact of John Broadus Watson on American psychology: The necessity of comparative parameters.

J Hist Behav Sci 2019 Feb 20. Epub 2019 Feb 20.

Center for Behavioral Theory and Research (CNTP) and Graduate Program in Behavioral Theory and Research (PPGTPC), Federal University of Pará, Belém, Pará, Brazil.

In recent decades, various studies have challenged the traditional view that John Broadus Watson's Behaviorist Manifesto prompted a psychological revolution. However, methodological hindrances underlie all these attempts to evaluate the impact of Watson's study, such as the absence of comparative parameters. This article remedies this problem by conducting a comparative citation analysis involving Watson and eight other representative psychologists of the time: J. Read More

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http://dx.doi.org/10.1002/jhbs.21962DOI Listing
February 2019

Is it true that gut microbiota is considered as panacea in cancer therapy?

J Cell Physiol 2019 Feb 20. Epub 2019 Feb 20.

Department of Immunology, Semnan University of Medical Sciences, Semnan, Iran.

Recent studies demonstrated that a combination of the gut microbiome has the vital effect on the efficacy of anticancer immune therapies. Regulatory effects of microbiota have been shown in different types of cancer therapies such as chemotherapy and immunotherapy. Immune-checkpoint-blocked therapies are the recent efficient cancer immunotherapy strategies. Read More

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http://dx.doi.org/10.1002/jcp.28333DOI Listing
February 2019

White noise speech illusions in the general population: The association with psychosis expression and risk factors for psychosis.

PLoS One 2019 20;14(2):e0211914. Epub 2019 Feb 20.

Department of Psychiatry and Psychology, Maastricht University Medical Centre, Maastricht, The Netherlands.

Introduction: Positive psychotic experiences are associated with increased rate of white noise speech illusions in patients and their relatives. However, findings have been conflicting to what degree speech illusions are associated with subclinical expression of psychosis in the general population. The aim of this study was to investigate the link between speech illusions and positive psychotic experiences in a general population sample. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211914PLOS
February 2019

Oil palm plantations in Peninsular Malaysia: Determinants and constraints on expansion.

PLoS One 2019 20;14(2):e0210628. Epub 2019 Feb 20.

Department of Geographical Sciences, University of Maryland, College Park, Maryland, United States of America.

Agricultural expansion is one of the leading causes of deforestation in the tropics and in Southeast Asia it is predominantly driven by large-scale production for international trade. Peninsular Malaysia has a long history of plantation agriculture and has been a predominantly resource-based economy where expanding plantations like those of oil palm continue to replace natural forests. Habitat loss from deforestation and expanding plantations threatens Malaysian biodiversity. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210628PLOS
February 2019

How the medium shapes the message: Printing and the rise of the arts and sciences.

PLoS One 2019 20;14(2):e0205771. Epub 2019 Feb 20.

The MIT Media Lab, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

Communication technologies, from printing to social media, affect our historical records by changing the way ideas are spread and recorded. Yet, finding statistical evidence of this fact has been challenging. Here we combine a common causal inference technique (instrumental variable estimation) with a dataset on nearly forty thousand biographies from Wikipedia (Pantheon 2. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205771PLOS
February 2019

Moderate plant water stress improves larval development, and impacts immunity and gut microbiota of a specialist herbivore.

PLoS One 2019 20;14(2):e0204292. Epub 2019 Feb 20.

Organismal and Evolutionary Biology Research Programme, University of Helsinki, Helsinki, Finland.

While host plant drought is generally viewed as a negative phenomenon, its impact on insect herbivores can vary largely depending on the species involved and on the intensity of the drought. Extreme drought killing host plants can clearly reduce herbivore fitness, but the impact of moderate host plant water stress on insect herbivores can vary, and may even be beneficial. The populations of the Finnish Glanville fritillary butterfly (Melitaea cinxia) have faced reduced precipitation in recent years, with impacts even on population dynamics. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204292PLOS
February 2019

Markedly Reduced Risk of Internal Malignancies in Patients With Vitiligo: A Nationwide Population-Based Cohort Study.

J Clin Oncol 2019 Feb 20:JCO1801223. Epub 2019 Feb 20.

11 Yeouido St Mary's Hospital College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: Recent studies indicated that the autoimmunity of vitiligo exerts effects on cells other than melanocytes, which confer reduced risks of both melanoma and nonmelanoma skin cancers in patients with vitiligo. However, the risk of internal malignancy in patients with vitiligo has not been elucidated.

Patients And Methods: We conducted a population-based retrospective cohort study using data from the Korean National Health Insurance claims database obtained from January 2007 to December 2016. Read More

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http://dx.doi.org/10.1200/JCO.18.01223DOI Listing
February 2019

Parallel distributed networks resolved at high resolution reveal close juxtaposition of distinct regions.

J Neurophysiol 2019 Feb 20. Epub 2019 Feb 20.

Harvard.

Examination of large-scale distributed networks within the individual reveals details of cortical network organization that are absent in group-averaged studies. One recent discovery is that a distributed transmodal network, often referred to as the 'default network', is comprised of two closely interdigitated networks, only one of which is coupled to posterior parahippocampal cortex. Not all studies of individuals have identified the same networks and questions remain about the degree to which the two networks are separate, particularly within regions hypothesized to be interconnected hubs. Read More

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http://dx.doi.org/10.1152/jn.00808.2018DOI Listing
February 2019

Increased preparation time reduces, but does not abolish, action history bias of saccadic eye movements.

J Neurophysiol 2019 Feb 20. Epub 2019 Feb 20.

School of Human Movement Studies, The University of Queensland, Australia.

The characteristics of movements are strongly history-dependent. Marinovic et al. (2017a) showed that past experience influences the execution of limb movements through a combination of temporally-stable processes that are strictly use-dependent, and dynamically-evolving and context-dependent processes that reflect prediction of future actions. Read More

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http://dx.doi.org/10.1152/jn.00512.2018DOI Listing
February 2019

Sustaining Evidence-Based Interventions and Policies: Recent Innovations and Future Directions in Implementation Science.

Am J Public Health 2019 Feb;109(S2):S132-S134

Both authors are with the Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University, New York, NY. Rachel C. Shelton is also a Guest Editor for this supplement issue.

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http://dx.doi.org/10.2105/AJPH.2018.304913DOI Listing
February 2019

Need for Innovation in Public Health Research.

Am J Public Health 2019 Feb;109(S2):S117-S120

Ralph DiClemente is with the Department of Social and Behavioral Sciences, New York University College of Global Public Health, New York, NY. Azure Nowara, Rachel Shelton, and Gina Wingood are with the Lerner Center for Public Health Promotion and the Department of Sociomedical Sciences, Columbia University Mailman School of Public Health, New York, NY. Azure Nowara, Rachel Shelton, and Gina Wingood are also Guest Editors for this supplement issue.

The recent conference Turning the Tide: A New Generation of Public Health Interventions highlighted the need to utilize innovative and emergent methodologies to confront increasingly complex public health challenges. In this commentary, we discuss three dominant themes from the conference: addressing multiple levels of causality in reducing health problems; technology-based methodologies to enhance health promotion; and improving translation and sustainment of effective health promotion programs. The subsequent articles, included in this supplement issue of AJPH, provide compelling examples and arguments supporting these progressive approaches to public health promotion. Read More

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http://dx.doi.org/10.2105/AJPH.2018.304876DOI Listing
February 2019

Timing of Renal Replacement Therapy for Severe Acute Kidney Injury in Critically Ill Patients.

Am J Respir Crit Care Med 2019 Feb 20. Epub 2019 Feb 20.

Hôpital Louis Mourier, Réanimation Médico-Chirurgicale, Colombes, France ;

Acute kidney injury (AKI) affects many intensive care unit patients and is responsible for increased morbidity and mortality. Although life-saving in many situations, renal replacement therapy (RRT) may be associated with complications and the appropriate timing of its initiation is still the subject of intense debate. An early initiation strategy can prevent some metabolic complications whereas a delayed one may allow for renal function recovery in some patients without need for this costly and potentially dangerous technique. Read More

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http://dx.doi.org/10.1164/rccm.201810-1906CPDOI Listing
February 2019

Cofactor Analogues as Active Site Probes in Lysine Acetyltransferases.

J Med Chem 2019 Feb 20. Epub 2019 Feb 20.

Lysine acetyltransferases (KATs, also termed histone acetyltransferases, HATs) catalyze the acetylation of substrate lysine residues by employing the cofactor acetyl-coenzyme A (AcCoA), thereby providing a dynamic control mechanism of protein function. Because of their major involvement in cell development and homeostasis, small molecule modulators of KAT activity are urgently needed to assess their therapeutic potential and for probing their underlying biology. Recent advances in the field suggest that targeting the cofactor binding site represents a promising strategy for identifying potent and selective ligands. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.8b01887DOI Listing
February 2019

TDP-43: A KEY THERAPEUTIC TARGET BEYOND AMYOTROPHIC LATERAL SCLEROSIS.

ACS Chem Neurosci 2019 Feb 20. Epub 2019 Feb 20.

Accumulation of TDP-43 in the cytoplasm of diseased neurons is the pathological hallmark of Frontotemporal Dementia-TDP (FTLD-TDP) and Amyotrophic Lateral Sclerosis (ALS), two diseases that lack of efficacious medicine to prevent or to stop disease progression. The discovery that mutations in the TARDBP gene (coding for the nuclear protein known as TDP-43) in both FTLD and ALS patients provided evidence for a link between TDP-43 alterations and neurodegeneration. The knowledge of TDP-43 function has advanced profoundly in the last years, however its complete role and the molecular mechanisms that lead to disease have yet to be fully understood. Read More

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http://dx.doi.org/10.1021/acschemneuro.9b00026DOI Listing
February 2019

Faecal calprotectin in inflammatory bowel diseases: a review focused on meta-analyses and routine usage limitations.

Clin Chem Lab Med 2019 Jan 7. Epub 2019 Jan 7.

Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Spain.

A growing body of evidence has been published about the usefulness of measuring calprotectin in faecal samples (FCAL) in inflammatory bowel disease (IBD) assessment, including diagnosis, monitoring of disease activity and relapse prediction. Several systematic reviews with meta-analyses compiling studies for each particular clinical setting have been carried out in recent years. Most of these were focused on the use of FCAL in IBD diagnosis and showed a relevant role for this marker in selecting patients with gastrointestinal symptoms who would not need a further examination by endoscopy. Read More

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http://dx.doi.org/10.1515/cclm-2018-1063DOI Listing
January 2019

Hematologic parameters and neutrophil / lymphocyte ratio in the prediction of urethroplasty success.

Int Braz J Urol 2019 Feb 15;45. Epub 2019 Feb 15.

Department of Urology, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.

Objective: The pathophysiology of urethral stricture and its recurrence remains vague and one of the important causes is progressive infl ammation. It has been shown in recent years that the neutrophil / lymphocyte ratio is a marker of systemic infl ammation and is associated with prognosis in many cardiovascular diseases, malignancies and chronic infl ammatory diseases. We assessed simple systemic infl ammation markers preoperatively and surgical techniques for urethral stricture recurrence after urethroplasty. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0682DOI Listing
February 2019

[The skin as « third kidney »].

Rev Med Suisse 2019 Feb;15(639):418-421

Service de néphrologie et d'hypertension, CHUV, 1011 Lausanne.

The skin is the largest human organ playing an important role in protection, thermoregulation and sensation. Recent studies suggest that a new function has to be added: the storage of sodium. There is increasing evidence that sodium can accumulate in the skin, which suggests that the skin contributes to the regulation of sodium balance in humans, and possibly to the control of extracellular volume and blood pressure homeostasis. Read More

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February 2019

Controlling Chirality across Length Scales using DNA.

Small 2019 Feb 20:e1805419. Epub 2019 Feb 20.

Physics Department, TU München, Am Coulombwall 4a/II - 85748 Garching b., München, Germany.

Nano-objects with chiral properties attract growing interest due to their relevance for a wide variety of technological applications. For example, chiral nano-objects may be used in characterization platforms that involve chiral molecular recognition of proteins or in the fabrication of nanomechanical devices such as screw-gears or nanoswimmers. Spatial ordering of emitters of circularly polarized light might greatly benefit from the utilization of chiral shapes. Read More

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http://dx.doi.org/10.1002/smll.201805419DOI Listing
February 2019

Fetal iGRASP cine CMR assisting in prenatal diagnosis of complicated cardiac malformation with impact on delivery planning.

Clin Physiol Funct Imaging 2019 Feb 20. Epub 2019 Feb 20.

Lund University, Skåne University Hospital, Department of Clinical Sciences Lund, Clinical Physiology, Lund, Sweden.

Limited visualisation of the fetal heart and vessels by fetal ultrasound due to suboptimal fetal position, patient habitus and skeletal calcification may lead to missed diagnosis, overdiagnosis and parental uncertainty. Counseling and delivery planning may in those cases also be tentative. The recent fetal cardiac magnetic resonance (CMR) reconstruction method utilising tiny golden angle iGRASP (iterative Golden-angle RAdial Sparse Parallel MRI) allows for cine imaging of the fetal heart for use in clinical practice. Read More

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http://dx.doi.org/10.1111/cpf.12566DOI Listing
February 2019

A Molecular Cable Car for Transmembrane Ion Transport.

Authors:
Alberto Credi

Angew Chem Int Ed Engl 2019 Feb 20. Epub 2019 Feb 20.

CLAN-Center for light activated nanostructures, Università di Bologna and Consiglio Nazionale delle Ricerche, Via Gobetti 101, 40129, Bologna, Italy.

The controlled transport of molecular and ionic substrates across bilayer membranes is a fundamental task for the operation of living organisms. It is also a highly fascinating and demanding challenge for artificial molecular machines. The recent report of a synthetic transmembrane molecular shuttle that can transport potassium ions selectively down a gradient in a liposomal system makes a small but significant step towards this goal. Read More

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http://dx.doi.org/10.1002/anie.201814333DOI Listing
February 2019

Interplay between miRNAs and host genes and their role in cancer.

Brief Funct Genomics 2019 Feb 20. Epub 2019 Feb 20.

Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.

MicroRNAs (miRNAs) are small endogenous non-coding functional RNAs that post-transcriptionally regulate gene expression. They play essential roles in nearly all biological processes including cell development and differentiation, DNA damage repair, cell death as well as intercellular communication. They are highly involved in cancer, acting as tumor suppressors and/or promoters to modulate cell proliferation, epithelial-mesenchymal transition and tumor invasion and metastasis. Read More

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http://dx.doi.org/10.1093/bfgp/elz002DOI Listing
February 2019

POTENTIAL PREVENTIVE EFFECT OF LACTOBACILLUS ACIDOPHILUS AND LACTOBACILLUS PLANTARUM IN PATIENTS WITH POLYPS OR COLORECTAL CÂNCER.

Arq Gastroenterol 2018 Oct-Dec;55(4):407-411

Alborz University of Medical Sciences, School of Medicine, Department of Microbiology, Karaj, Iran.

Background: Colorectal cancer is one of the major causes of death worldwide. Many studies have been done on the biology of its formation as well as its treatment in recent years. One of the factors involved in the formation or treatment of this malignancy can be attributed to the microbial flora in the intestine. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-87DOI Listing

GASTRIC FUNDIC GLAND POLYPS: CAN HISTOLOGY BE USEFUL TO PREDICT PROTON PUMP INHIBITORS USE?

Arq Gastroenterol 2018 Oct-Dec;55(4):380-384

Universidade Federal de Sergipe, Departamento de Medicina, Aracaju, SE, Brasil.

Background: Fundic gland polyps allegedly increased in frequency in recent decades, and had attracted great attention due to possible association with prolonged proton pump inhibitor therapy. Prolonged use of this drug could cause parietal cell hyperplasia, obstruction of glandular lumen and cystic dilation of the gland.

Objective: This study aims to analyze clinical and pathological features of fundic gland polyps in patients with and without proton pump inhibitor therapy in a selected population from Brazil. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-82DOI Listing

Recent advances in layered double hydroxides applied to photoprotection.

Einstein (Sao Paulo) 2019 Feb 18;17(1):eRW4456. Epub 2019 Feb 18.

Universidade Federal de Alagoas, Maceió, AL, Brazil.

Layered double hydroxides have received more attention from researchers due to their range of applications, ease of synthesis and low cost of production. With broader knowledge about solar radiation effects on the body, the use of sunscreens has become even more important. The ability of some nanostructures, such as layered double hydroxides, to act as matrices has made it possible to obtain improvements in photoprotective formulations, with solutions to problems caused by radiation and sunscreens. Read More

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http://dx.doi.org/10.31744/einstein_journal/2019RW4456DOI Listing
February 2019

Counteracting the contemporaneous proliferation of digital forgeries and fake news.

An Acad Bras Cienc 2019 Feb 14;91(suppl 1):e20180149. Epub 2019 Feb 14.

Institute of Computing, University of Campinas (Unicamp), Av. Albert Einstein, 1251, 13083-852 Campinas, SP, Brazil.

Fake news has been certainly the expression of the moment: from political round table discussions to newspapers to social and mainstream media. It is everywhere. With such an intense discussion and yet few effective ways to combat it, what can be done? Providing methods to fight back even the least harming hoax is a social responsibility. Read More

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http://dx.doi.org/10.1590/0001-3765201820180149DOI Listing
February 2019

Tuning bimetallic catalysts for a selective growth of SWCNTs.

Nanoscale 2019 Feb 20. Epub 2019 Feb 20.

Laboratoire de Physique des Interfaces et des Couches Minces, CNRS, Ecole Polytechnique, 91128, Palaiseau Cedex, France.

Recent advances in structural control during the synthesis of SWCNTs have in common the use of bimetallic nanoparticles as catalysts, despite the fact that their exact role is not fully understood. We therefore analyze the effect of the catalyst's chemical composition on the structure of the resulting SWCNTs by comparing three bimetallic catalysts (FeRu, CoRu and NiRu). A specific synthesis protocol is designed to impede the catalyst nanoparticle coalescence mechanisms and stabilize their diameter distributions throughout the growth. Read More

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http://dx.doi.org/10.1039/c8nr09589bDOI Listing
February 2019

Superconductivity in bilayer graphene intercalated with alkali and alkaline earth metals.

Phys Chem Chem Phys 2019 Feb 20. Epub 2019 Feb 20.

Institute of Physics, Czstochowa University of Technology, Ave. Armii Krajowej 19, 42-200 Czstochowa, Poland.

With the enormous research activity focused on graphene in recent years, it is not surprising that graphene superconductivity has become an attractive area of research. To date, no superconducting properties have been experimentally observed in the pristine form of graphene but controllable structure manipulation is a promising way to induce a superconducting state in graphene-based systems. Therefore, herein we investigate the possible superconductivity in two-layer graphene intercalated with atoms of alkali and alkaline earth metals. Read More

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http://dx.doi.org/10.1039/c9cp00176jDOI Listing
February 2019

Genetic Diversity and Structure in Regional Cercospora beticola Populations from Beta vulgaris ssp. vulgaris Suggest Two Clusters of Separate Origin.

Phytopathology 2019 Feb 20. Epub 2019 Feb 20.

Cornell University, Department of Plant Pathology and Plant-Microbe Biology , Barton Laboratory , 630 West North Street , Geneva, New York, United States , 14456 ;

Cercospora leaf spot, caused by Cercospora beticola, is a highly destructive disease of Beta vulgaris ssp. vulgaris worldwide. Cercospora beticola populations are usually characterized by high genetic diversity, but little is known of the relationships among populations from different production regions around the world. Read More

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http://dx.doi.org/10.1094/PHYTO-07-18-0264-RDOI Listing
February 2019

Update and future perspective of behavioral medicine in the treatment for chronic pain.

Pain Manag 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry, University of California Irvine, CA 92868, USA 92868.

Chronic pain is a biopsychosocial condition, and behavioral medicine has made significant contributions to the understanding of the phenomenon and optimization of therapeutic outcomes. The objective of this article is to provide future perspectives of behavioral medicine in pain management based upon recent development in the field. We will briefly review the mainstream approach of cognitive-behavioral therapy, its variations and new and innovative approaches that are on the horizon. Read More

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http://dx.doi.org/10.2217/pmt-2017-0055DOI Listing
February 2019

Arteriovenous Conduits for Hemodialysis: How to Better Modulate the Pathophysiological Vascular Response to Optimize Vascular Access Durability.

Am J Physiol Renal Physiol 2019 Feb 20. Epub 2019 Feb 20.

Division of Nephrology and Department of Medicine, University of Alabama at Birmingham, United States.

Vascular access is the lifeline for hemodialysis patients. Arteriovenous fistulas (AVFs) are the preferred vascular access but AVF maturation failure remains a significant clinical problem. Currently there are not any effective therapies available to prevent or treat AVF maturation failure. Read More

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http://dx.doi.org/10.1152/ajprenal.00440.2018DOI Listing
February 2019

Tissue Continues to Be the Issue: Role of Histopathology in the Context of Recent Updates in the Radiologic Classification of Interstitial Lung Diseases.

Arch Pathol Lab Med 2019 Jan;143(1):30-33

From the Department of Pathology, Kaiser Permanente Santa Clara, Santa Clara, California (Dr Raparia); and the Department of Pulmonary and Critical Care Medicine, Stanford University School of Medicine, Palo Alto, California (Dr Raj).

Context.—: High-resolution computed tomography (HRCT) imaging has an increasingly important role in clinical decision-making in patients with interstitial lung diseases. The recent Fleischner Society white paper on the diagnostic criteria for idiopathic pulmonary fibrosis highlights the advances in our understanding of HRCT imaging in interstitial lung diseases. Read More

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http://dx.doi.org/10.5858/arpa.2018-0134-RADOI Listing
January 2019

Direct Reaction Between Copper and Nitrogen at High Pressures and Temperatures.

J Phys Chem Lett 2019 Feb 20. Epub 2019 Feb 20.

Transition metal nitrides have applications in a range of technological fields. Recent experiments have shown that new nitrogen-bearing compounds can be accessed through a combination of high temperatures and pressures, revealing a richer chemistry than was previously assumed. Here, we show that at pressures above 50 GPa and temperatures greater than 1500 K the elemental copper reacts with nitrogen forming copper diazenide (CuN). Read More

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http://dx.doi.org/10.1021/acs.jpclett.9b00070DOI Listing
February 2019

Structure-based In Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library.

J Med Chem 2019 Feb 20. Epub 2019 Feb 20.

Potent Ebolavirus (EBOV) inhibitors will help to curtail outbreaks such as that which occurred in 2014-16 in West Africa. EBOV has on its surface a single glycoprotein (GP) critical for viral entry and membrane fusion. Recent high resolution complexes of EBOV GP with a variety of approved drugs revealed that binding to a common cavity prevented fusion of the virus and endosomal membranes, inhibiting virus infection. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.8b01328DOI Listing
February 2019

Abnormal Microtubule Dynamics Impair the Nuclear-Cytoplasmic Transport in Dementia.

ACS Chem Neurosci 2019 Feb 20. Epub 2019 Feb 20.

Molecular and Structural Biophysics Laboratory, Department of Biochemistry , North-Eastern Hill University , Umshing, Shillong 793022 , Meghalaya , India.

Disrupted nuclear-cytoplasmic transport (NCT) is a common pathophysiological event in several neurodegenerative disorders. However, the correlation between the mutations in the pathogenic microtubule-associated protein tau and NCT and neuronal dysfunction is not yet clearly understood. A recent study revealed that tau is mislocalized to the neuronal cell body and, thus, deforms the nuclear membrane in the frontotemporal dementia (FTD). Read More

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http://dx.doi.org/10.1021/acschemneuro.9b00079DOI Listing
February 2019
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