290 results match your criteria Recent Patents on Anti-Infective Drug Discovery [Journal]


Promising role of Wolbachia as anti-parasitic drug target and eco-friendly biocontrol agent.

Recent Pat Antiinfect Drug Discov 2019 Feb 11. Epub 2019 Feb 11.

Department of Parasitology, Toxoplasmosis Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari. Iran.

Background: Wolbachia is the most common endosymbiotic bacteria in insect-borne parasites and it is the most common reproductive parasite in the world. Wolbachia has been found worldwide in numerous arthropod and parasite species, including: insects, terrestrial isopods, spiders, mites and filarial nematodes. There is a complicated relationship between Wolbachia and its hosts and in some cases, they create a mutual relationship instead of a parasitic relationship. Read More

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http://dx.doi.org/10.2174/1574891X14666190211162403DOI Listing
February 2019

Patent Selections.

Authors:

Recent Pat Antiinfect Drug Discov 2018 ;13(2):187-188

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http://dx.doi.org/10.2174/1574891X1302181106123737DOI Listing
January 2019
1 Read

Nanomedicine Advances in Topical Infective and Non-Infective Skin Diseases Therapy.

Recent Pat Antiinfect Drug Discov 2018 ;13(2):104

University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh, India.

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http://dx.doi.org/10.2174/1574891X1302181106123659DOI Listing
January 2019
8 Reads

Biological Efficacy of Carvacrol Analogues.

Recent Pat Antiinfect Drug Discov 2018 ;13(3):207-216

Department of Chemistry, Faculty of Science and Agriculture, University of Fort Hare, Alice Campus, Eastern Cape, South Africa.

Background: Carvacrol is the major constituent of essential oils derived from plants. It exhibits antimicrobial, antioxidant, anticancer, anti-inflammatory, and anticholinesterase activity. The analogues of carvacrol can be prepared via selected synthetic routes, resulting in potent compounds. Read More

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http://dx.doi.org/10.2174/1574891X14666181205111821DOI Listing
January 2018
9 Reads

Topical nano-emulgel for skin disorders: Formulation approach and characterization.

Recent Pat Antiinfect Drug Discov 2018 Nov 28. Epub 2018 Nov 28.

Department of pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER)-Raebareli, Uttar Pradesh (UP). India.

Backgrounds: Acne vulgaris is a common chronic skin disease that affects approximately 650 million people or about 9.4% of the population globally. Growing research in the area of nanotechnology over the years has now been exploited in management of various human disorders by their application in drug delivery. Read More

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http://dx.doi.org/10.2174/1574891X14666181129115213DOI Listing
November 2018
12 Reads

Polymyxin Resistance Mechanisms: From Intrinsic Resistance to Mcr Genes.

Recent Pat Antiinfect Drug Discov 2018 ;13(3):198-206

Department of Microbiology, AHEPA University Hospital, S. Kiriakidi Str. 1, 54636, Thessaloniki, Greece.

The global spread of carbapenemase-encoding genes among Gram-negative nosocomial pathogens has led to the revival of polymyxins. Colistin and polymyxin B, despite their serious adverse effects, have become last resort treatment options for multi- or even extensively-drug-resistant bacterial infections due to Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa. Their use, however, has been followed by an increase in polymyxin resistance rates and the spread of transferable resistance genes limiting further the treatment options and contributing to the emergence of pan-drug-resistance. Read More

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http://dx.doi.org/10.2174/1574891X14666181126142704DOI Listing
January 2018
3 Reads

Patent Selections.

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Recent Pat Antiinfect Drug Discov 2018 ;13(1):100-102

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http://dx.doi.org/10.2174/1574891X1301180927103816DOI Listing
December 2018
1 Read

Preface.

Authors:
Dieter Kabelitz

Recent Pat Antiinfect Drug Discov 2018 ;13(1)

Institute of Immunology Universitatsklinikum Schleswig-Holstein Campus Kiel Arnold-Heller-Straße 3 Kiel, Germany.

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http://dx.doi.org/10.2174/1574891X1301180927103705DOI Listing
December 2018
1 Read

Ibalizumab and Fostemsavir in the Management of Heavily Pre-Treated HIV-infected Patients.

Recent Pat Antiinfect Drug Discov 2018 ;13(3):190-197

Infectious Diseases Unit, Department of Internal Medicine, Policlinico San Martino Hospital, Genoa, Italy.

Background: Heavily treated HIV-1 infected patients may have limited therapeutic alternatives. In order to ensure sustained HIV-RNA suppression in these patients and to improve current antiretroviral treatment regimens in the fight against multi-drug resistant strains, new drugs are needed. Recently, two new drugs among the new generation of entry inhibitors showed promises for both their characteristics and mechanism of action. Read More

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http://dx.doi.org/10.2174/1574891X13666181031120019DOI Listing
January 2018
3 Reads

HIV/AIDS Curable Study: New Forms of Therapeutic Trinity.

Recent Pat Antiinfect Drug Discov 2018 ;13(3):217-227

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Background And Aims: AIDS (acquired immune deficient syndrome), a deadly human infectious disease is caused by HIV (human immunodeficiency viruses) infection. Patient's mortality was eventually reduced to one-fourth by combined chemotherapy (usually 3 chemical drugs simultaneously) than earlier HIV/AIDS treatments (single drug or vaccine) in the clinic.

Results: Combined treatments against HIV/AIDS are still incurable for all patients despite a high rate of patient's survival. Read More

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http://dx.doi.org/10.2174/1574891X13666181026094526DOI Listing
January 2018
4 Reads

Levofloxacin Versus Ceftriaxone and Azithromycin Combination in the Treatment of Community Acquired Pneumonia in Hospitalized Patients.

Recent Pat Antiinfect Drug Discov 2018 ;13(3):228-239

Graduation Program of Health Sciences, Faculty of Medicine, Federal University of Mato Grosso, Cuiaba, Brazil.

Background: In Asia, an estimated one million deaths are caused by communityacquired pneumonia (CAP) each year. Despite the high mortality in elderly people, a large number of CAP patients have been treated and survived with optimal life expectancy. A few studies have been done on adult CAP therapeutic approaches in Asia. Read More

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http://dx.doi.org/10.2174/1574891X13666181024154526DOI Listing
January 2018
5 Reads

Ultrastructural Investigation of Promastigotes Treated with A New Potent Antileishmanial Azole Using Scanning Electron and Atomic Force Microscopes.

Recent Pat Antiinfect Drug Discov 2018 ;13(3):246-255

Immunogenetics Research Center, Department of Medical Nanotechnology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Aim And Background: Azoles as antifungal drugs have been used to treat leishmaniasis for many years. Several evidences suggesting that the primary target of azoles is the heme protein, which co-catalyzes cytochrome P-450-dependent 14α-demethylation of lanosterol. Little is known about the structural changes caused by azoles with atomic force microscopy (AFM) or scanning electron microscopy (SEM). Read More

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http://dx.doi.org/10.2174/1574891X13666180918121628DOI Listing
January 2018
10 Reads

Nanotechnological Carriers for Treatment of Acne.

Recent Pat Antiinfect Drug Discov 2018 ;13(2):105-126

I. K. Gujral Punjab Technical University, Jalandhar-Punjab 144601, India.

Background: Acne is a multifactorial skin disease associated with pilosebaceous unit and caused by bacteria Propionibacterium acnes and Acne vulgaris. Near about 95% people throughout the world suffer from acne at some point in their life span. This disease is more prominent in adults compared to neonates and prepubescent children. Read More

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http://dx.doi.org/10.2174/1574891X13666180918114349DOI Listing
January 2019
17 Reads

Amarogentin as topical anticancer and anti-infective potential: Scope of lipid based vesicular in its effective delivery.

Recent Pat Antiinfect Drug Discov 2018 Sep 13. Epub 2018 Sep 13.

Faculty of Health Sciences, Shalom Institute of Health and Allied Sciences (SIHAS) Sam Higginbottom University of Agriculture, Technology and Sciences Allahabad, 211007, Uttar Pradesh. India.

There is the need of development of liposomes based nanomedicines formulation for the better efficacy and safety of the available drugs in the market. Liposomes have various applications in the field of pharmaceutical and medical field for their drug target potential, diagnostic importance and imaging techniques. Natural plant based drugs and their derivative have been used in the medicine, nutraceuticals, perfumery, cosmetic and beverages industry. Read More

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http://www.eurekaselect.com/165434/article
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http://dx.doi.org/10.2174/1574891X13666180913154355DOI Listing
September 2018
7 Reads

Nano-Based Therapy for Treatment of Skin Cancer.

Recent Pat Antiinfect Drug Discov 2018 ;13(2):151-163

Glocal School of Pharmacy, The Glocal University, Saharanpur, Uttar Pradesh, India.

Background: According to the World Health Organization, skin cancer is the most common malignancy for the population. Conventional skin cancer treatment includes surgery and chemotherapy, but many of the chemotherapeutic agents used present undesirable properties. There are a number of patents on topical nano formulation like nanoparticle (US9757453; US9457041), liposomes (US2018177726 (A1), has been covered in this review in the treatment of skin cancer. Read More

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http://dx.doi.org/10.2174/1574891X13666180911095440DOI Listing
January 2019
2 Reads

Antibacterial Activity of Gold Nanoparticles Conjugated by Aminoglycosides Against Isolates from Burn Patients.

Recent Pat Antiinfect Drug Discov 2018 ;13(3):256-264

Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background And Objective: Today, resistance to multiple classes of antibiotics, and notably to the β-lactam and aminoglycosides in A. baumannii is becoming a great problem and it necessitates to make a new approach to combat with multidrug-resistant (MDR), extensive drug-resistance (XDR) or Pandrug-resistant (PDR) isolates. In this case, a new strategy and ways should be designed and introduced against such infections. Read More

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http://dx.doi.org/10.2174/1574891X13666180828115543DOI Listing
January 2018
18 Reads

Screening and Potential of the Incidence of Resistance Transfer Among the Multidrug and Heavy Metal Resistant Gram-Negative Isolates from Hospital Effluents of Northern India.

Recent Pat Antiinfect Drug Discov 2018 ;13(2):164-179

Department of Biosciences, Integral University, Lucknow, India.

Background: Hospital wastewater has a high amount of both organic and inorganic matter, as well as high densities of living organisms, including pathogenic, and environmental bacteria. It has been suggested that genes encoding resistance to an antibiotic can be located together with heavy metals resistance genes on either the same genetic structure (plasmid) or different genetic structures within the same bacterial strain. Resistance transfer is mainly attributed to conjugation since many antimicrobial resistance genes are situated on mobile elements, such as plasmids and conjugative transposons, whereas renovation and transduction are usually more limited. Read More

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http://dx.doi.org/10.2174/1574891X13666180702111330DOI Listing
January 2019
13 Reads

Short Antimicrobial Peptides.

Recent Pat Antiinfect Drug Discov 2018 ;13(1):12-52

Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S. A. S. Nagar, Punjab 160062, India.

Background: After the era of serendipitous discovery of penicillin and outburst in the discovery and development of highly efficient antibiotics, a surge in resistance against the target specific drugs was observed, primarily due to a combination of selective pressure of antibiotics use and spontaneous mutations. As per the World Health Organization, antibiotic resistance is one of the greatest threats to the mankind.

Objective: Short antimicrobial peptides (SAMPs) can be considered as a viable therapeutic alternative to conventional antibiotics in tackling resistant microbes. Read More

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http://dx.doi.org/10.2174/1574891X13666180628105928DOI Listing
December 2018
4 Reads

In Vitro Anti-mycobacterial Activity of Three Medicinal Plants of Lamiaceae Family.

Recent Pat Antiinfect Drug Discov 2018 ;13(3):240-245

Department of Medical Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Mycobacterium tuberculosis as an intracellular pathogen causes Tuberculosis (TB). Due to the long time required for treatment, hepatotoxicity of drugs and also emergence of Multidrug-Resistant (MDR) and Extremely Drug Resistant (XDR) strains, TB is currently a major public health problem. Some medicinal plants possess remarkable activity against Mycobacterium. Read More

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http://dx.doi.org/10.2174/1574891X13666180626170155DOI Listing
January 2018
17 Reads

Current State of Nanomedicines in the Treatment of Topical Infectious Disorders.

Recent Pat Antiinfect Drug Discov 2018 ;13(2):127-150

University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160 014, India.

Background: Topical infections, involving a number of diseases such as impetigo, eczema, pustular acne, psoriasis and infected seborrheic dermatitis are one among the many challenges to health which stand out for their profound impact on human species. The treatment of topical infections has always been a difficult proposition because of the lack of efficacy of existing anti-infectives, longer period of treatment and yet incomplete recovery. The increasing emergence of antibiotic resistant bacterial strains like Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa undermines the need for the development of new delivery systems to enhance the therapeutic efficacy of existing topical anti-infectives. Read More

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http://dx.doi.org/10.2174/1574891X13666180529103804DOI Listing
January 2019
4 Reads

Evaluation of Fosfomycin Activity Against Extended Spectrum Beta Lactamase (ESBL) Producing Enterobacteriaceae Isolated from Three Centers of Tehran, Iran.

Recent Pat Antiinfect Drug Discov 2018 ;13(2):180-186

Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: Rising rates of antimicrobial resistance among Enterobacteriaceae limit the use of reliably active forms of available drugs. The aim of this study was to investigate the prevalence of fosfomycin (US6794490B2) resistance gene among ESBL producing isolates in Iran.

Method: We tested 355 isolates of Enterobacteriacea collected from various clinical samples including urine, wounds, blood and other sources during June 2016 to July 2017. Read More

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http://dx.doi.org/10.2174/1574891X13666180517075803DOI Listing
January 2019
8 Reads

Multi-Drug Resistant Clinical Pseudomonas aeruginosas Inhibited by Ferula gummosa Boiss.

Recent Pat Antiinfect Drug Discov 2018 ;13(1):89-99

Baqiyatallah University of Medical Sciences, Tehran, Iran.

Background: Multi-drug resistance among Pseudomonas aeruginosa (P. aeruginosa) clinical isolates is increasing and becoming a serious problem for public health authorities worldwide.

Objective: The aim of the current study is to introduce a potent antibacterial compound against the resistant P. Read More

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http://dx.doi.org/10.2174/1574891X13666180426163427DOI Listing
December 2018
6 Reads

Macrophage Targeted Cellular Carriers for Effective Delivery of Anti-Tubercular Drugs.

Recent Pat Antiinfect Drug Discov 2017 ;12(2):162-183

DM IMS, BHU, Varanasi, Uttar Pradesh, 221005, India

Background: Newly developed vaccine VPM1002 confers paradigm swing in the prophylactic treatment of tuberculosis (TB). Multi-drug resistant and latent TB in adults as well as in underprivileged patients is instigating menace over world population if the host is immune-compromised.

Methods: One third of the world's population is infected with TB. Read More

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http://dx.doi.org/10.2174/1574891X13666171207151313DOI Listing
July 2018
8 Reads

Recent Patents on Light-Based Anti-Infective Approaches.

Recent Pat Antiinfect Drug Discov 2018 ;13(1):70-88

Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

Background: Antibiotic resistance is one of the most serious health threats to modern medicine. The lack of potent antibiotics puts us at a disadvantage in the fight against infectious diseases, especially those caused by antibiotic-resistant microbial strains. To this end, an urgent need to search for alternative antimicrobial approaches has arisen. Read More

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http://dx.doi.org/10.2174/1872213X11666171108104104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938159PMC
December 2018
16 Reads

Current Progress in Synthesis, Characterization and Applications of Silver Nanoparticles: Precepts and Prospects.

Recent Pat Antiinfect Drug Discov 2018 ;13(1):53-69

Nanomedicine Research Lab, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.

Background: Silver nanoparticles (AgNPs), are amongst the utmost striking nanosized materials that are extensively applied in a variety of biomedical applications which includes diagnostic use, disease management, medical device coating, drug delivery and for personal health care.

Discussion: With the growing interest and its application in the health care sector, it is becoming necessary for a better understanding and exploration of AgNPs mechanism of action like biological interaction, their possible toxicity, and safety concern to human exposure. AgNPs have been the subject of researchers attention and interest due to the unique properties and quality such as shape and size depending optical, electrical, and antimicrobial potentials (antibacterial, antifungal, antiviral etc. Read More

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http://dx.doi.org/10.2174/1574891X12666171006102833DOI Listing
December 2018
41 Reads

New Drugs and Vaccines for Tuberculosis.

Recent Pat Antiinfect Drug Discov 2017 ;12(2):147-161

Department of Pharmaceutical Chemistry, I.T.S College of Pharmacy, Delhi-Meerut Road, Murad Nagar, Ghaziabad-201206, India.

Background: Tuberculosis (TB) is an infectious disease that resulted in estimated 9.6 million new cases in 2014 and 1.5 million deaths. Read More

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http://dx.doi.org/10.2174/1574891X12666171006105921DOI Listing
July 2018
7 Reads

Recent Complications and Issues in Tuberculosis Treatment.

Recent Pat Antiinfect Drug Discov 2017 ;12(2):138-146

KIET School of Pharmacy, Ghaziabad, U.P., India.

Background: Tuberculosis is one of the major communicable diseases which can be prevented and cured. The prevalence of tuberculosis infection is more despite this disease causes major morbidity and mortality. To establish connection between tuberculosis (TB) related stigma and hindrance in search of a treatment after the inception of symptoms associated with tuberculosis. Read More

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http://dx.doi.org/10.2174/1574891X12666171006104430DOI Listing
July 2018
51 Reads

Nanostructured Therapeutic Carriers for Tuberculosis Treatment: Approaches & Challenges.

Recent Pat Antiinfect Drug Discov 2017 ;12(2):128-137

Department of Pharmaceutical Medicine, Hamdard University, New Delhi, India.

Background: The diseases tuberculosis, triggered by intracellular pathogens, is a major problem for the global medical professionals. Treatments for these diseases through conventional dosage form consist of long-term therapy with multiple drugs, leading to several side effects and contribute to low patient compliance and drug resistance. The pathogens are found to be situated in the intracellular compartments of the cells, which ultimately results in additional blockades to effective treatment. Read More

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http://dx.doi.org/10.2174/1574891X12666171006105409DOI Listing
July 2018
25 Reads

Bedaquiline: A New Hope for Shorter and Better Anti-Tuberculosis Regimens.

Recent Pat Antiinfect Drug Discov 2018 ;13(1):3-11

Infectious Disease Department, IRCCS AOU San Martino IST, University of Genoa, Genoa, Italy.

Background: In 2014, an estimated 1.8 million people died from Mycobacterium tuberculosis (MTB); moreover, 680,000 people developed multidrug-resistant TB (MDRTB).

Methods: Currently available anti-MDR and XDR regimens are long-lasting and expensive, need high adherence and are undermined by a high frequency of adverse drug events, thus leading to a low success rate; furthermore, in the last 50 years only two new molecules, bedaquiline (BDQ) and delamanid, have been approved and released for the treatment of MDR-TB. Read More

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http://dx.doi.org/10.2174/1574891X12666170619101904DOI Listing
December 2018
5 Reads

Recently Patented Viral Nucleotide Sequences and Generation of Virus-Derived Vaccines.

Recent Pat Antiinfect Drug Discov 2017 ;12(1):31-43

Cell and Systems Biology, University of Toronto, M5G 3B2A, Toronto, Canada.

Background: With an increase in comprehension of the molecular biology of viruses, there has been a recent surge in the application of virus sequences and viral gene expression strategies towards the diagnosis and treatment of diseases.

Results: The scope of the patenting landscape has widened as a result and the current review discusses patents pertaining to live / attenuated viral vaccines. The vaccines addressed here have been developed by both conventional means as well as by the state-of-the-art genetic engineering techniques. Read More

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http://www.eurekaselect.com/153416/article
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http://dx.doi.org/10.2174/1574891X12666170619102506DOI Listing
June 2018
6 Reads

Nano-carriers for the Treatment of Tuberculosis.

Recent Pat Antiinfect Drug Discov 2017 ;12(2):95-106

Glocal School of Pharmacy, Glocal University, Saharanpur-247121, Uttar Pradesh, India.

Background: Nano size based drug delivery systems are an emerging technique with the potential to develop new strategies involving handling of drugs at the nanometer scale. There are many nano-based drug delivery systems that have been extensively reported as drug carriers for the treatment of tuberculosis.

Methods: There are numerous nano sized drug delivery systems like lipid nanoparticles, polymeric micelle, carbon nanotubes and polymeric nanoparticles that have been reported for a long time to treat diseases. Read More

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http://dx.doi.org/10.2174/1574891X12666170427120230DOI Listing
July 2018
17 Reads

An Overwiev of ORF Virus Infection in Humans and Animals.

Recent Pat Antiinfect Drug Discov 2017 ;12(1):21-30

Department of Infectious Diseases, Faculty of Medicine, Erciyes University, 38039-Kayseri. Turkey.

Background: Orf virus is a DNA virus that belongs to the Parapoxvirus genus. The virus is a causative agent of orf in humans or contagious ecthyma in animals which is mostly seen in sheep, goat and cattle.

Discussion: Orf is an emerging zoonosis with an increasing number of worldwide outbreaks that have been reported. Read More

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http://dx.doi.org/10.2174/1574891X12666170602080301DOI Listing
June 2018
21 Reads

Nanoemulsion-Based Transdermal Drug Delivery System for the Treatment of Tuberculosis.

Recent Pat Antiinfect Drug Discov 2017 ;12(2):107-119

H.K. College of Pharmacy, H.K. Building, Partiksha Nagar Relief Road, Oshiwara, Jogeshwari (W), Mumbai-400102, India.

Background: The nanoemulsion based carriers are the most suitable delivery systems for poorly soluble drugs to improve the drugs solubility, permeation of drugs and ultimately increase bioavailability by transdermal therapeutic system. The nanoemulsion for poorly soluble drugs is admirable and offered several advantages over others drug delivery.

Methods: For nanoemulsions formulation, they have to deliver the energetic element at the specific organ with nominal uneasiness. Read More

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http://dx.doi.org/10.2174/1574891X12666170602075733DOI Listing
July 2018
23 Reads

Antibiotic Effects of Loperamide: Homology of Human Targets of Loperamide with Targets in Acanthamoeba spp.

Recent Pat Antiinfect Drug Discov 2017 ;12(1):44-60

The Department of Biological and Biomedical Sciences, Aga Khan University, Medical College, Karachi, Pakistan.

Background: Loperamide is an anti-diarrheal drug prescribed for non-infectious diarrhea. The drug is an opioid receptor agonist, blocker of voltage-dependent calcium channel (Cav) and calmodulin (CaM) inhibitor on human cells. Loperamide has been reported to exert anti-amoebic effects against pathogenic strains of Acanthamoeba castellanii. Read More

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http://dx.doi.org/10.2174/1574891X12666170425170544DOI Listing
June 2018
18 Reads

Optimization of Microemulsion Based Transdermal Gel of Triamcinolone.

Recent Pat Antiinfect Drug Discov 2017 ;12(1):61-78

Department of Pharmaceutics, MAEER's Maharashtra Institute of Pharmacy, MIT Campus, S. No. 124, Kothrud, Pune 411038, Savitribai Phule Pune University, Pune. India.

Background: Triamcinolone is a long acting corticosteroid used in the treatment of arthritis, eczema, psoriasis and similar conditions which cause inflammation. Triamcinolone has half-life of 88min. Prolonged oral use is associated with gastrointestinal adverse effects as peptic ulcer, abdominal distention and ulcerative esophagitis as described in various patents. Read More

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http://dx.doi.org/10.2174/1574891X12666170426092911DOI Listing
June 2018
21 Reads

Nanoemulsion for the Effective Treatment and Management of Anti-tubercular Drug Therapy.

Recent Pat Antiinfect Drug Discov 2017 ;12(2):85-94

Department of Pharmacy, Shri Venkateshwara University, Amroha, Uttar Pradesh, India.

Background: Tuberculosis is considered as one of the deadliest diseases of human existence. Since ancient age the treatment of tuberculosis has been highly challenging primarily owing to the pathogenic nature of the Mycobacterium and its diverse spots of localization in human body including lungs, liver, spleen, eye, meninges and lymph nodes.

Methods: The conventional drug therapy employed for the treatment of tuberculosis is not highly satisfactorily owing to low oral bioavailability of the drugs. Read More

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http://www.eurekaselect.com/152145/article
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http://dx.doi.org/10.2174/1574891X12666170504094330DOI Listing
July 2018
17 Reads

Current Approaches and Future Prospects of Nanomedicine in Tuberculosis Therapy.

Recent Pat Antiinfect Drug Discov 2017 ;12(2):120-127

Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Background: Tuberculosis (TB), which is caused by the Mycobacterium tuberculosis, is a serious threat and one of the major health problems worldwide.

Objective: In recent years, an estimated of 9.6 million TB cases occurred and 1. Read More

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http://www.eurekaselect.com/151870/article
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http://dx.doi.org/10.2174/1574891X12666170425122416DOI Listing
July 2018
14 Reads

Oral Colonization by Nosocomial Pathogens During Hospitalization in Intensive Care Unit and Prevention Strategies.

Recent Pat Antiinfect Drug Discov 2017 Oct;12(1):8-20

Department of Medical Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Critically ill patients are very susceptible to a variety of disorders and infections during hospitalization in Intensive Care Units [ICU]. Among these problems, nosocomial infections are major causes of morbidity and mortality.

Methods: Nosocomial pneumonias, specifically ventilator associated pneumonias have become a major health care issue. Read More

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http://www.eurekaselect.com/150131/article
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http://dx.doi.org/10.2174/1574891X12666170215152854DOI Listing
October 2017
31 Reads

3rd Generation of Cephalosporins and Monobactam Resistant Among Pathogenic Bacteria Collected from Ilam Hospitals During 2008 to 2015: A Systematic Review and Meta-Analysis.

Recent Pat Antiinfect Drug Discov 2017 ;12(1):3-7

Razi Herbal Medicines Research Center & Department of Microbiology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

Background: Recently, increasing antibiotic resistance is causing serious publichealth concerns worldwide. This phenomenon increased patient's morbidity and mortality rate, particularly in immunocompromised individuals.

Methods: Considering that antimicrobial resistance can vary according to geographical location, we investigated the status of antibiotic resistance in Ilam province from 2008 to 2013. Read More

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http://dx.doi.org/10.2174/1574891X12666170130101006DOI Listing
June 2018
5 Reads

Editorial: Nanomedicines for the Treatment of Tuberculosis: Role of Nanocarriers and Functional Excipients.

Recent Pat Antiinfect Drug Discov 2017 ;12(2):84

Product Development Research Jubilant Generics Limited Noida, U.P., India.

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http://dx.doi.org/10.2174/1574891X1202180503101725DOI Listing
November 2018
2 Reads

Targets and Patented Drugs for Chemotherapy of Chagas Disease in the Last 15 Years-Period.

Authors:
Vilma G Duschak

Recent Pat Antiinfect Drug Discov 2016 ;11(2):74-173

Area de Bioquimica de Proteinas y Glicobiologia de Parasitos. Departamento de Investigacion. Instituto Nacional de Parasitologia "Dr. Mario Fatala Chaben", ANLIS-Malbran, Ministerio de Salud de la Nacion. Av. Paseo Colon 568 (1063), Buenos Aires, Argentina.

Background: The American trypanosomiasis, Chagas disease, is a parasitic infection typically spread by triatomine vectors affecting millions of people all over Latin America. Existing chemotherapy is centered on the nitroaromatic compounds benznidazole and nifurtimox that provide unsatisfactory results and substantial side effects. So, the finding and exploration of novel ways to challenge this neglected disease is a main priority. Read More

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http://dx.doi.org/10.2174/1574891X11666161024165304DOI Listing
March 2017
43 Reads

Detection of blaKPC and blaGES Carbapenemase Genes in Klebsiella pneumoniae Isolated from Hospitalized Patients in Kashan, Iran.

Recent Pat Antiinfect Drug Discov 2016 ;11(2):183-188

Department of Microbiology and Immunology, Kashan, 87159-88141, I.R. Iran.

Introduction: Klebsiella pneumoniae carbapenemase (KPC)-producing bacteria are among the highly antimicrobial resistant gram negative bacteria and infections due to them are an increasingly major health problem worldwide.

Methods: In this study we have detected the blaKPC and blaGES carbapenemase genes in Klebsiella pneumoniae isolated from hospitalized patients in Kashan, Iran. In a cross-sectional study, a total of 181 K. Read More

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http://dx.doi.org/10.2174/1574891X11666160813192556DOI Listing
March 2017
8 Reads

Correlation Between qacE and qacE∆1 Efflux Pump Genes, Antibiotic and Disinfectant Resistant Among Clinical Isolates of E.coli.

Recent Pat Antiinfect Drug Discov 2016 ;11(2):189-195

Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.

Introduction: Antiseptics and disinfectants have been used widely in hospitals and other health care settings to control the growth of microorganisms. However, some disinfectant resistant strains were reported. The objectives of our study were to evaluate correlation between the efflux pump genes, drugs and disinfectant resistant among clinical isolates of E. Read More

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http://dx.doi.org/10.2174/1574891X11666160815094718DOI Listing
March 2017
19 Reads

Complement 3 Receptor Expression in Individuals with Type 2 Diabetes.

Recent Pat Antiinfect Drug Discov 2016 ;11(2):174-182

Microbiology/Immunology, Department of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, 309 E Second Street, Pomona, CA 91766-1854. United States.

Background: According to the World Health Organization, as of 2014 9% of the world's adult population is affected by diabetes. Uncontrolled diabetes is a pro-inflammatory process that increases generation of reactive oxygen species (ROS).

Methods: The production of ROS leads to a chronic increase in oxidative stress which results in an increased susceptibility to infections. Read More

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http://dx.doi.org/10.2174/1574891X11666160608121617DOI Listing
March 2017
22 Reads

Lipid-based Vesicular Nanocargoes as Nanotherapeutic Targets for the Effective Management of Rheumatoid Arthritis.

Recent Pat Antiinfect Drug Discov 2016 ;11(1):3-15

Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom Institute of Agriculture, Technology & Sciences (SHIATS), Allahabad, India.

Background: Rheumatoid arthritis (RA) is an immune mediated joint-based chronic inflammatory disorder recognized by joint inflammation, destruction, pain and remission. Currently, numerous pharmacotherapeutic strategies have gained immense popularity in RA therapy and improving the patient life.

Methods: Besides, it exhibits numerous drawbacks such as requirement of high dose of drugs, unavoidable adverse effects and diseases remission. Read More

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March 2017
70 Reads

Hybolites Revisited.

Recent Pat Antiinfect Drug Discov 2016 ;11(1):16-31

Theoretical Biology Unit, EA 4312, Faculty of Science, University of Rouen, 76821 Mont Saint Aignan Cedex - France.

Background: Hyperstructures are large assemblies of molecules and macromolecules that perform functions such as metabolism (including RNA and protein synthesis and degradation), transport, DNA replication, cell division, signalling and chemotaxis.

Methods: Such hyperstructures might be manipulated by hybrid metabolites or hybolites made by a pairwise, covalently linked combination of the thousands of small molecules involved in metabolism and signalling.

Results: Here, we review recent evidence for hyperstructures in prokaryotes and for interactions between hyperstructures as a determinant of the phenotype. Read More

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March 2017
2 Reads

Effect of Low Dose Oral Vitamin-D and Calcium Replacement in HIV Patients.

Recent Pat Antiinfect Drug Discov 2016 ;11(1):59-67

Department of HIV Medicine, Coventry & Warwickshire Partnership Trust, Coventry, UK.

Background: There is high prevalence of vitamin-D deficiency and abnormal bone mineral density (BMD) in HIV patients. Our aim is to find out the effect of replacement of low dose oral vitamin-D (800 International unit) with calcium (500mg) as a once daily regimen along with antiretroviral (ARV) on serum vitamin-D and parathyroid hormone (PTH) level and bone mineral density (BMD) changes on patients with HIV infection who have vitamin- D deficiency.

Methods: This is a non-randomised, open label study. Read More

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March 2017
2 Reads

The Antidiabetic Effects of The Bioactive Flavonoid (Kaempferol-3-O-β-D-6{P- Coumaroyl} Glucopyranoside) Isolated From Allium cepa.

Recent Pat Antiinfect Drug Discov 2016 ;11(1):44-52

Department of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.

Background: Allium cepa has been in use in traditional medicine in the treatment of diabetes mellitus. The aqueous and ethanolic extracts have been found effective in lowering blood glucose levels in experimental diabetic rats and guinea pigs.

Methods: The study was carried out to isolate the active principle responsible for the observed hypoglycaemic effect in experimental animals. Read More

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March 2017
7 Reads

Effect of Pistacia atlantica Fruit and Leaf Extracts on Hydatid Cyst Protoscolices.

Recent Pat Antiinfect Drug Discov 2016 ;11(1):53-8

Department of Parasitology and Mycology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.

Background: Treatment of human hydatidosis is mainly surgical, with chemical treatment being reserved as a coadjuvant treatment. Use of effective protoscolicidal agents during surgery of hydatid disease is essential to reduce the recurrence rate.

Objective: The aim of this study was to investigate the scolicidal effects of Pistacia atlantica leaf and fruit hydroalcoholic extracts on protoscolices of hydatid cyst. Read More

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March 2017
10 Reads

Methicillin-Resistant Staphylococcus aureus: Treatment with Cultures of Non Drug-Resistant Staphylococcus epidermidis.

Recent Pat Antiinfect Drug Discov 2015 ;10(2):124-7

Research Field: Neural Networks in Neurological and Psychiatric Diseases, Euro Akademie Pößneck, Higher Vocational School of Elderly Care and Occupational Therapy, Carl- Gustav-Vogel-Str. 13, 07381 Pößneck, Germany.

The colonization and infection with methicillin-resistant Staphylococcus aureus is a major health problem in hospitals and long-term care facilities. Although bacteriaemias with MRSA (methicillin-resistant Staphylococcus aureus) can be treated with vancomycin and other reserve antibiotics, 20% of patients cannot be successfully cured. Inpatients colonized with MRSA are isolated in hospitals according to the guidelines of the Robert-Koch-Institute, although in long-term care facilities these patients are not urgently isolated. Read More

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August 2016
2 Reads