417,734 results match your criteria Real Living with Multiple Sclerosis [Journal]


Potential Role of microRNA-183 as a Tumor Suppressor in Hepatocellular Carcinoma.

Cell Physiol Biochem 2018 Dec 6;51(5):2065-2072. Epub 2018 Dec 6.

Department of General Surgery of East District, The Second Hospital of Hebei Medical University, Shijiazhuang,

Background/aims: Disseminated tumors, known as metastases, are responsible for ninety-percent of mortality due to cancer. Epithelial to mesenchymal transition, a phenomenon required for morphological conversion of non-motile discoid shaped epithelial cells to highly motile spindle-shaped mesenchymal cells, is thought to be a pre-requisite for metastatic progression. Metastasis-associated 1 (MTA1) protein is a prime inducer of EMT and metastatic progression in all solid tumors including hepatocellular carcinoma (HCC). Read More

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December 2018
8 Reads

Virtual Reality Simulation in Peritoneal Dialysis Training: The Beginning of a New Era.

Blood Purif 2018 Dec 6:1-5. Epub 2018 Dec 6.

Weltenmacher GmbH, VR Training-Application, Düsseldorf, Germany.

Background/aim: Peritonitis rates in peritoneal dialysis (PD) vary considerably not only across countries but also between centers in the same country. Patient education has been shown to significantly reduce infection rates but up till now training lacks standardization with patients being trained using different methods and media (e.g. Read More

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December 2018
3 Reads

miR-122 Targets X-Linked Inhibitor of Apoptosis Protein to Sensitize Oxaliplatin-Resistant Colorectal Cancer Cells to Oxaliplatin-Mediated Cytotoxicity.

Cell Physiol Biochem 2018 Dec 6;51(5):2148-2159. Epub 2018 Dec 6.

Minimally Invasive Treatment Center, Fudan University Shanghai Cancer Center, Shanghai,

Background/aims: Although oxaliplatin is one of the most effective chemotherapeutic drugs used to treat colorectal cancer (CRC), long-term administration usually induces acquired drug resistance during the course of treatment. Thus, there is an urgent need to explore novel strategies to improve the efficiency of cancer therapy. The aim of this study was to explore the effect of microRNA-122 (miR-122) on reversing oxaliplatin resistance in CRC. Read More

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December 2018
3 Reads

miR-202 Enhances the Anti-Tumor Effect of Cisplatin on Non-Small Cell Lung Cancer by Targeting the Ras/MAPK Pathway.

Cell Physiol Biochem 2018 Dec 6;51(5):2160-2171. Epub 2018 Dec 6.

Background/aims: KRas is usually mutated in non-small cell lung cancer (NSCLC). The mutated KRas gene is a negative prognostic indicator that promotes tumor proliferation, metastasis, and drug resistance in NSCLC, and thus has become a target for cancer therapy. This study is focused on the effects of the microRNA (miR)-202/KRas axis in regulating chemosensitivity in NSCLC. Read More

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December 2018
1 Read

An approach to the implementation of Low Impact Development measures towards an EcoCampus classification.

J Environ Manage 2018 Dec 3;232:654-659. Epub 2018 Dec 3.

ECT-School of Science and Technology, University of Trás-os-Montes e Alto Douro UTAD, Quinta de Prados, 5000-801 Vila Real, Portugal; Centre for Transdisciplinary Development Studies, University of Trás-os-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal.

Impervious cover has important hydrologic impacts, namely the increased runoff volume and peak discharges in the rainwater network, which can lead to significant consequences like rapid urban floods with social, environmental and economic implications. LID (Low Impact Development) consist of distributed runoff management measures, like green roofs, pervious pavements, waterways covered with vegetation and filter trails, among others, that seek to control stormwater in the origin, reducing imperviousness. These solutions avoid increased runoff rate and volume, increase infiltration and groundwater recharge. Read More

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December 2018
1 Read

A photoelectrochemical sensing strategy based on single-layer MoS modified electrode for methionine detection.

J Pharm Biomed Anal 2018 Nov 28;165:94-100. Epub 2018 Nov 28.

Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, State Key Laboratory Base of Eco-Chemical Engineering, Key Laboratory of Rubber-Plastics of Ministry of Education/Shandong Provincial Key Laboratory of Rubber Plastics, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China. Electronic address:

MoS, a typical transition metal disulfide, is widely used in the photoelectrochemical (PEC) sensor construction. In general, MoS based PEC sensor are "signal-on" strategies. Surprisingly, we discovered that the PEC response of MoS was quenched by methionine greatly. Read More

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November 2018
2 Reads

Highly effective and safe intermediate based on deep eutectic medium for carrier less-three phase hollow fiber microextraction of antiarrhythmic agents in complex matrices.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Nov 7;1104:196-204. Epub 2018 Nov 7.

Department of Chemistry, Semnan University, Semnan 35195-363, Iran.

For the first time, three phase hollow fiber liquid phase microextraction using an influential, and green middle phase comprised a new relatively-hydrophobic deep eutectic solvent (three-phase HF-LPME-DES) was developed for trace analyses of antiarrhythmic drugs in biological and environmental samples. The extraction solvent was easily synthesized by mixing the green and cheap raw materials, namely choline chloride and 1-phenylethanol (ChCl: Ph-ETOH), in the ambient temperature. Good compatibility to pores of hollow-fiber, high ability for extraction of ionizable organic compounds with no need to any carrier agents, and easy availability in the laboratory environment turned this new proposed deep eutectic intermediate to a worthy generation of the supported liquid membrane (SLM). Read More

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November 2018
2 Reads

A simple yet sensitive colorimetric nitrite ions assay based on diazotization with p‑Aminobenzoic and coupling with phloroglucinol in acidic medium.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Aug 25;210:398-404. Epub 2018 Aug 25.

Key Laboratory of Bioelectrochemistry & Analysis of Gansu Province, College of Chemistry& Chemical Engineering, Northwest Normal University, Lanzhou 730070, PR China. Electronic address:

Immoderate intake of nitrite (NO) is deleterious human health and may result in causing dangerous diseases. In this study, nitrite detection system was successfully fabricated based on a unique diazo-coupling reaction of p‑Aminobenzoic acid (PABA) and phloroglucinol (1, 3, 5‑trihydroxybenzene). Upon the presence of NO in an acid medium, p‑Aminobenzoic acid could not only form diazonium ion easily but also couple with p‑Aminobenzoic acid, and results forming yellow water-soluble azo dye that shows maximum absorption at 434 nm. Read More

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August 2018
6 Reads

Er Shen Wan extract alleviates polyuria and regulates AQP 2 and AVPR 2 in a rat model of spleen-kidney Yang deficiency-induced diarrhea.

Biomed Pharmacother 2018 Dec 3;110:302-311. Epub 2018 Dec 3.

College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, PR China; Sichuan Neo-Green Pharmaceutical Technology Development Co., Ltd, Chengdu 610081, PR China. Electronic address:

Ethnopharmacological Relevance: Er Shen Wan (ESW), has been empirically used for treating spleen-kidney Yang deficiency (SKYD) syndrome in Traditional Chinese medicine (TCM) for centuries and shows a variety of activities. The medicinal formula is a mixture of two component herbs, Psoraleae Fructus (PF, Bu-Gu-Zhi in Chinese) and Myristicae Semen (MS, Rou-Dou-Kou in Chinese). The current study was designed to evaluate ESWP antidiuretic treatment of polyuria and to explore potential mechanisms of renal water metabolism in the rat model of SKYD-induced diarrhea. Read More

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December 2018
1 Read

Wuzhi capsule (Schisandra Sphenanthera extract) attenuates liver steatosis and inflammation during non-alcoholic fatty liver disease development.

Biomed Pharmacother 2018 Dec 3;110:285-293. Epub 2018 Dec 3.

Department of Organ Transplantation, ChangZheng Hospital, Second Military Medical University, Shanghai, 200003, China. Electronic address:

Objective: Wuzhi (WZ) capsule contains an ethanol extract of Schisandra sphenanthera. The efficacy of WZ in treating non-alcoholic fatty liver disease (NAFLD) has not yet been elucidated. The present study assessed the effects of WZ on NAFLD. Read More

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December 2018
2 Reads
2.023 Impact Factor

A sensitive biosensing method for detecting of ultra-trace amounts of AFB1 based on "Aptamer/reduced graphene oxide" nano-bio interaction.

Colloids Surf B Biointerfaces 2018 Dec 1;175:98-105. Epub 2018 Dec 1.

Department of Chemistry, Payame Noor University (PNU), P.O. Box: 19395-4697, Tehran, Iran. Electronic address:

A simple, low-cost and sensitive label-free aptasensor assembled with assisting reduced graphene oxide nanosheets as the signal amplifier was fabricated and applied for detecting ultra-low levels of Aflatoxin B1(AFB1) through a nano-bio interaction system. The conditions of different modified glassy carbon electrodes as the base of aptasensor were investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS). The performance of the fabricated aptasensor was evaluated by FESEM, HRTEM and AFM images. Read More

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December 2018

Interstitial Lung Disease Onset and Its Risk Factors in Japanese Patients with ALK-positive NSCLC Following Treatment with Crizotinib.

J Thorac Oncol 2018 Dec 3. Epub 2018 Dec 3.

Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

Introduction: The study objective was to determine the incidence and characteristics of drug-induced interstitial lung disease (ILD) associated with an orally available small-molecule tyrosine kinase inhibitor, crizotinib in the real-world clinical setting.

Methods: Post-marketing surveillance was performed in Japan to obtain information on the safety and efficacy of crizotinib. Target patients included all patients with anaplastic lymphoma kinase-positive non-small cell lung cancer (NSCLC) who received crizotinib, during the enrollment period between May 2012 and December 2014. Read More

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December 2018
5 Reads

22kHz and 55kHz ultrasonic vocalizations differentially influence neural and behavioral outcomes: Implications for modeling anxiety via auditory stimuli in the rat.

Behav Brain Res 2018 Dec 3. Epub 2018 Dec 3.

Developmental Neuropsychobiology Lab, Department of Psychology, Northeastern University, 360 Huntington Ave NI125, Boston, MA, 02115, United States. Electronic address:

The communicative role of ultrasonic vocalizations (USVs) in rats is well established, with distinct USVs indicative of different affective states. USVs in the 22 kHz range are typically emitted by adult rats when in anxiety- or fear-provoking situations (e.g. Read More

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December 2018

MiR-15b is a key regulator of proliferation and apoptosis of chondrocytes from patients with condylar hyperplasia by targeting IGF1, IGF1R and BCL2.

Osteoarthritis Cartilage 2018 Dec 3. Epub 2018 Dec 3.

Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei province, China. Electronic address:

Objective: This study aimed to explore potential microRNAs (miRNAs), which participate in the pathological process of condylar hyperplasia (CH) through targeting specific proliferation- and apoptosis-related genes of chondrocytes.

Methods: Insulin-like growth factor 1 (IGF1), IGF1 receptor (IGF1R) and B-cell CLL/lymphoma 2 (BCL2) in CH cartilage were detected by real-time PCR, Western blot, immunohistochemistry and immunofluorescence. MiRanda and TargetScanS algorithms were used to predict certain miRNAs in CH chondrocytes concurrently modulating the above three genes. Read More

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December 2018
1 Read

A new automated device for quantifying mechanical nociceptive responses.

J Neurosci Methods 2018 Dec 3. Epub 2018 Dec 3.

Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University School of Medicine, New York, NY, USA; Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY, USA. Electronic address:

Background: Traditional methods to assess pain in rodents depend on measures of nociceptive responses, most commonly from the hind paws. While these measures can quantify nociceptive responses to allow pharmacologic testing, they typically have high inter-experimenter variability and are not time-sensitive enough to correct with neural processes that occur on millisecond scales.

New Method: We have invented a pain detection device that uses changes in skin conductance to measure nocifensive withdrawal responses. Read More

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December 2018
4 Reads

A diagnostic study comparing conventional and real-time PCR for Strongyloides stercoralis on urine and on faecal samples.

Acta Trop 2018 Dec 3. Epub 2018 Dec 3.

Centre for Tropical Diseases, IRCCS Sacro Cuore Don Calabria Hospital, Negrar 37024, Italy.

Strongyloides stercoralis is a soil-transmitted helminth with a wide distribution in tropical and subtropical areas. The diagnosis of S. stercoralisinfection can be challenging, due to the low sensitivity of microscopic examination of stool samples and coproculture. Read More

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December 2018

Overexpression of heat shock protein HSP90AA1 and translocase of the outer mitochondrial membrane TOM34 in HCV-induced hepatocellular carcinoma: A pilot study.

Clin Biochem 2018 Dec 3. Epub 2018 Dec 3.

Department of Biochemistry, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. Electronic address:

Objective: Identification of new molecular markers to enhance early diagnosis, prognosis and/or treatment of hepatocellular carcinoma (HCC) is a need. TOM34 (34 kDa-translocase of the outer mitochondrial membrane) protein expression deregulation has demonstrated to be involved in the growth of many cancers. Here, we aimed at evaluating serum TOM34 and some heat shock proteins (HSPA4, HSPA1B, and HSP90AA1) expressions in hepatitis C virus (HCV)-related cirrhosis and HCV-induced HCC relative to controls and correlating these expressions to the clinicopathological data. Read More

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December 2018
6 Reads

Quantitative Detection of Fipronil and Fipronil-Sulfone in Sera of Black-Tailed Prairie Dogs and Rats after Oral Exposure to Fipronil by Camel Single-Domain Antibody-Based Immunoassays.

Anal Chem 2018 Dec 6. Epub 2018 Dec 6.

The insecticide fipronil can be metabolized to its sulfone in mammalian species. Two camel single-domain antibodies (VHHs) F1 and F6, selective to fipronil and fipronil-sulfone, respectively, were generated and used to develop enzyme linked immunosorbent assays (ELISAs) for the detection of the two compounds in the sera of black-tailed prairie dogs and rats. The limits of detection of fipronil and fipronil-sulfone in the rodent sera by the corresponding ELISAs were 10 and 30 ng mL-1, and the linear ranges were 30-1000 and 75-2200 ng mL-1. Read More

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December 2018

Teledermatology for diagnosing skin cancer in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD013193. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised with potential to infiltrate and damage surrounding tissue. Anxiety around missing early curable cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions. Read More

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December 2018
6 Reads

Reflectance confocal microscopy for diagnosing cutaneous melanoma in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD013190. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Early detection and treatment is key to improving survival; however, anxiety around missing early cases needs to be balanced against appropriate levels of referral and excision of benign lesions. Read More

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December 2018
4 Reads

The effect of the configurations of fiducial markers on accuracy of surgical navigation in zygomatic implant placement: An in vitro study.

Int J Oral Maxillofac Implants 2018 Dec 5. Epub 2018 Dec 5.

Purpose: Real-time surgical navigation has been increasingly applied in implant placement. The initial registration procedures were found to substantially affect the overall accuracy of the system for zygomatic implant placement, but the exact number and distribution of fiducial markers was yet undetermined. This study aimed to determine the minimal numbers and optimal distributions of fiducial markers to achieve clinically acceptable accuracy in surgical navigation, through systematically analyzing the effects of different setups of fiducial markers on target registration errors (TRE). Read More

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December 2018
1 Read

Accuracy of Calcium Scoring calculated from contrast-enhanced Coronary Computed Tomography Angiography using a dual-layer spectral CT: A comparison of Calcium Scoring from real and virtual non-contrast data.

PLoS One 2018 6;13(12):e0208588. Epub 2018 Dec 6.

Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Purpose: Modern non-invasive evaluation of Coronary Artery Disease (CAD) requires non-contrast low dose Computed Tomography (CT) imaging for determination of Calcium Scoring (CACS) and contrast-enhanced imaging for evaluation of vascular stenosis. Several methods for calculation of CACS from contrast-enhanced images have been proposed before. The main principle for that is generation of virtual non-contrast images by iodine subtraction from a contrast-enhanced spectral CT dataset. Read More

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December 2018
1 Read

Spectral clustering with distinction and consensus learning on multiple views data.

PLoS One 2018 6;13(12):e0208494. Epub 2018 Dec 6.

School of Computer and Information Technology, Shanxi University, Taiyuan, China.

Since multi-view data are available in many real-world clustering problems, multi-view clustering has received considerable attention in recent years. Most existing multi-view clustering methods learn consensus clustering results but do not make full use of the distinct knowledge in each view so that they cannot well guarantee the complementarity across different views. In this paper, we propose a Distinction based Consensus Spectral Clustering (DCSC), which not only learns a consensus result of clustering, but also explicitly captures the distinct variance of each view. Read More

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December 2018

A study for multiscale information transfer measures based on conditional mutual information.

PLoS One 2018 6;13(12):e0208423. Epub 2018 Dec 6.

Department of Mathematics, College of Science, Beijing University of Chemical Technology, Beijing, China.

As the big data science develops, efficient methods are demanded for various data analysis. Granger causality provides the prime model for quantifying causal interactions. However, this theoretic model does not meet the requirement for real-world data analysis, because real-world time series are diverse whose models are usually unknown. Read More

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December 2018
2 Reads

Non-professional caregiver burden is associated with the severity of patients' cognitive impairment.

PLoS One 2018 6;13(12):e0204110. Epub 2018 Dec 6.

Center for Observational and Real-World Evidence, Merck & Co., Inc., Kenilworth, New Jersey, United States of America.

Background/objectives: To analyse the relationship between caregiver burden and severity of patients' cognitive impairment.

Design: Data were drawn from the cross-sectional 2015/2016 Adelphi Real World Dementia Disease-Specific Programme.

Setting: This research was multi-national and studied physicians and their consulting patients with cognitive impairment. Read More

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December 2018
1 Read

LINC01118 Modulates Paclitaxel Resistance of Epithelial Ovarian Cancer by Regulating miR-134/ABCC1.

Authors:
Cong Shi Min Wang

Med Sci Monit 2018 Dec 6;24:8831-8839. Epub 2018 Dec 6.

Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China (mainland).

BACKGROUND Epithelial ovarian cancer (EOC) has a high mortality rate and is a common malignant tumor of women, seriously impairing health. Chemoresistance is one of the major causes of poor prognosis. Therefore, analyzing the molecular mechanism of paclitaxel resistance has great significance. Read More

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December 2018
1 Read

Effect of high fat diet on NF-кB microRNA146a negative feedback loop in ovalbumin-sensitized rats.

Biofactors 2018 Dec 6. Epub 2018 Dec 6.

Lung Inflammatory Diseases Research Center, Department of Physiology, Ardabil University of Medical Sciences, Ardabil, Iran.

The present study aimed to investigate the role of microRNA-146a and its adapter proteins [interleukin-1 receptor-associated kinase 1 (IRAK1) and tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6)] in the pathogenesis of ovalbumin (OVA)-sensitized rats in association with the diet-induced obesity condition. Twenty male Wistar rats were divided into four groups: control with normal diet (ND), OVA-sensitized with normal diet (S + ND), high-fat diet (HFD), and OVA-sensitized with high-fat diet (S + HFD). All the animals were fed for 8 weeks with standard pelts or high-fat diet, and were then sensitized and challenged with OVA or saline for another 4 weeks. Read More

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December 2018
1 Read

Minimal residual disease-based long-term efficacy of reduced-intensity conditioning versus myeloablative conditioning for adult Philadelphia-positive acute lymphoblastic leukemia.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Hematology, Catholic Hematology Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea.

Background: The sensitivity of Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL) to reduced-intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (HCT) versus myeloablative conditioning (MAC) allogeneic HCT by minimal residual disease (MRD) kinetics is not well established.

Methods: This study compared long-term outcomes based on MRD kinetics for 79 patients with RIC transplants and 116 patients with MAC transplants in first complete remission (CR1) after tyrosine kinase inhibitor-based chemotherapy (median follow-up, 67.1 months). Read More

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December 2018
1 Read

Accurate and efficient estimation of small p-values with the cross-entropy method: applications in genomic data analysis.

Bioinformatics 2018 Dec 6. Epub 2018 Dec 6.

Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.

Motivation: Small p-values are often required to be accurately estimated in large-scale genomic studies for the adjustment of multiple hypothesis tests and the ranking of genomic features based on their statistical significance. For those complicated test statistics whose cumulative distribution functions are analytically intractable, existing methods usually do not work well with small p-values due to lack of accuracy or computational restrictions. We propose a general approach for accurately and efficiently estimating small p-values for a broad range of complicated test statistics based on the principle of the cross-entropy method and Markov chain Monte Carlo sampling techniques. Read More

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December 2018
1 Read

Luteal granulosa cells from natural cycles are more capable of maintaining their viability, steroidogenic activity and LH receptor expression than those of stimulated IVF cycles.

Hum Reprod 2018 Dec 6. Epub 2018 Dec 6.

Graduate School of Health Sciences, Koc University, Davutpasa, Topkapi, Istanbul, Turkey.

Study Question: Are there any differences in the molecular characteristics of the luteal granulosa cells (GC) obtained from stimulated versus non-stimulated (natural) IVF cycles that may help explain the defective luteal phase in the former?

Summary Answer: Luteal GC of stimulated IVF cycles, particularly those of agonist-triggered antagonist cycles, are less viable ex vivo, express LH receptor and anti-apoptotic genes at lower levels, undergo apoptosis earlier and fail to maintain their estradiol (E2) and progesterone (P4) production in comparison to natural cycle GC.

What Is Known Already: Luteal function is defective in stimulated IVF cycles, which necessitates P4 and/or hCG administration (known as luteal phase support) in order to improve clinical pregnancy rates and prevent miscarriage. The luteal phase becomes shorter and menstruation begins earlier than a natural cycle if a pregnancy cannot be achieved, indicative of early demise of corpus luteum (premature luteolysis). Read More

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December 2018

A mitochondria-targeted near-infrared fluorescent probe with a large Stokes shift for real-time detection of hypochlorous acid.

Org Biomol Chem 2018 Dec 6. Epub 2018 Dec 6.

Tianjin Key Laboratory for Photoelectric Materials and Devices, and Key Laboratory of Display Materials and Photoelectric Devices, Ministry of Education, School of Materials Science & Engineering, Tianjin University of Technology, Tianjin 300384, China. and School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China.

Hypochlorous acid (HOCl) has been known to be intertwined with various pathophysiological processes. In this paper, a novel mitochondria-targeted near-infrared (NIR) fluorescent probe L based on a chromenylium-phenothiazine conjugate has been designed and synthesized for the detection of hypochlorous acid. Due to the HOCl-promoted intramolecular charge transfer processes, the probe L shows near-infrared fluorescence emission at 672 nm, large Stokes shifts of 97 nm, fast response, and high selectivity and sensitivity. Read More

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December 2018

Inpatients Sign On: An Opportunity to Engage Hospitalized Patients and Caregivers Using Inpatient Portals.

Med Care 2018 Dec 4. Epub 2018 Dec 4.

Department of Pediatrics, University of Wisconsin School of Medicine and Public Health.

Background: Inpatient portals are online patient portals linked to electronic health records that provide hospitalized patients and caregivers secure access to real-time clinical information and tools to enhance their communication with providers and hospital experience.

Objective: The main objective of this commentary was to provide a perspective that inpatient portals are innovative tools poised to engage patients and caregivers during hospitalization and, thus, enhance patient-centered care.

Results: Inpatient portals are desired by patients and caregivers and may contribute to improved recognition of their inpatient care team, knowledge of their treatment plan and overall inpatient experience. Read More

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December 2018

The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland.

Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.

Department of Pathology, Stanford University School of Medicine, Stanford, CA.

The spectrum of tumors arising in the salivary glands is wide and has recently been shown to harbor a network of tumor-specific fusion genes. Acinic cell carcinoma (AciCC) is one of the more frequently encountered types of salivary gland carcinoma, but it has remained a genetic orphan until recently when a fusion between the HTN3 and MSANTD3 genes was described in one case. Neither of these 2 genes is known to be implicated in any other malignancy. Read More

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December 2018

Pembrolizumab in the treatment of advanced/metastatic melanoma: a single-center institution experience.

Melanoma Res 2018 Dec 4. Epub 2018 Dec 4.

Melanoma Medical Oncology Unit, Department of Medical Oncology and Hematology.

Pembrolizumab is an anti-programmed cell death-1 monoclonal antibody, currently representing the first-line treatment for advanced melanoma. Apart from registration trials, there is a paucity of data on its effectiveness and safety in a real-world setting. We retrospectively analyzed patients with metastatic melanoma treated at our institution in the context of an Expanded Access Program. Read More

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December 2018

Decision-Making Deficits in ADHD Are Not Related to Risk Seeking But to Suboptimal Decision-Making: Meta-Analytical and Novel Experimental Evidence.

J Atten Disord 2018 Dec 6:1087054718815572. Epub 2018 Dec 6.

4 The Hebrew University of Jerusalem, Israel.

Objective: ADHD is related to decision-making deficits in real-life (e.g., substance abuse) and on experimental tasks (increased preference for risky options). Read More

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December 2018

Cytometric Micro-Bead Magnetic Suspension Array for High-Throughput Ultra-Sensitive Detection of Aflatoxin B1.

Anal Chem 2018 Dec 6. Epub 2018 Dec 6.

High-throughput and low-cost detection of mycotoxins in complex matrices is becoming increasingly urgent but still challenged for ultra-sensitive analyses. Here we reported a green and practical cytometric micro-bead magnetic suspension array (CBMSA) strategy for rapid and economical detection of aflatoxin B1 (AFB1) in multiple batches of lotus seeds samples. The protocol included the fabrication of the suspension array chips by immobilizing the biotin-modified bovine serum albumin-AFB1 (antigen) onto the surface of streptavidin-coated magnetic micro-beads in a multi-wells array, the indirect immuno-competition of antigen and target of AFB1 in lotus seed samples with the specific antibodies, the rapid magnetic separation regardless complex pretreatment steps, and the ultra-sensitive fluorescence detection of fluorescein isothiocyanate labeled goat anti-mouse immunoglobulin G (FITC-IgG) probes. Read More

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December 2018
2 Reads

Basal insulin therapy: unmet medical needs in Asia and the new insulin glargine in diabetes treatment.

J Diabetes Investig 2018 Dec 6. Epub 2018 Dec 6.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

Diabetes remains a global epidemic problem and a tremendous health challenge especially in Asian population. Dramatic increases in the prevalence of diabetes across different countries or areas in Asia have been reported in recent epidemiological studies. While clinical guidelines have strengthen appropriate anti-hyperglycaemic medications and lifestyle modifications for optimal diabetes management, inadequate glycaemic control still occurs in many patients with an increased risk of developing microvascular and macrovascular complications. Read More

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December 2018
1 Read

Assembly of a miRNA-modified QCM sensor for miRNA recognition through response patterns.

J Mol Recognit 2018 Dec 6:e2772. Epub 2018 Dec 6.

School of Chemistry and Environment, South China Normal University, Guangzhou, China.

In this paper, a miRNA-based quartz crystal microbalance (QCM) biosensor was fabricated and used to the rapid and effective sensing of miRNA. The specific hybridization between probe miRNA and different selected miRNAs (miR-27a, miR-27b, and Let-7a) cause a different interaction mode, thus display different frequency change and response patterns in the QCM sensor, which were used to detect miR-27a and miR-27b. The selective sensing of miR-27a in mixed miRNA solution was also achieved. Read More

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December 2018

A revolution of photovoltaics: persistent electricity generation beyond solar irradiation.

Dalton Trans 2018 Dec 6. Epub 2018 Dec 6.

Institute of New Energy Technology, College of Information Science and Technology, Jinan University, Guangzhou 510632, PR China.

Renewable energy utilization by energy conversion devices is regarded as a promising solution to resolve energy crisis and environmental pollution problems. Solar energy occupies 99% of the total energy of the Earth; therefore, the development of photovoltaic technology to convert solar energy into electricity is attracting considerable interests. The state-of-the-art research in this field mainly focuses on the improvement of power conversion efficiency under the sunlight irradiation by new materials development, device structure optimization, technique innovation, etc. Read More

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December 2018
3 Reads

Visual detection of cancer cells by using in situ grown functional CuSe/reduced graphene oxide hybrids acting as an efficient nanozyme.

Analyst 2018 Dec 6. Epub 2018 Dec 6.

Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400716, P. R. China. and College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, P. R. China.

A simple protocol for in situ growth of Cu2-xSe nanoparticles on graphene oxide hybrids (Cu2-xSe/rGO) acting as an efficient nanozyme is developed and thus a sensitive visual detection method of cancer cells is proposed. The Cu2-xSe/rGO heterogeneous nanomaterials have been proven to exhibit high peroxidase-like activity to catalyze the reaction of the peroxidase substrate in the presence of hydrogen peroxide. Herein, we used Cu2-xSe/rGO as a signal transducer to develop a colorimetric assay for the direct detection of cancer cells and a total of 63 cancer cells (MCF-7) can be distinguished by naked-eye observation. Read More

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December 2018
1 Read

Circular RNA expression profiles of persistent atrial fibrillation in patients with rheumatic heart disease.

Anatol J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, Xijing Hospital, Air Force Military Medical University (Fourth Military Medical University); Xi'an-China.

Objective: To investigate the expression profile of circular RNAs (circRNAs) and proposed circRNA-microRNA (miRNA) regulatory network in atrial fibrillation (AF).

Methods: Atrial tissues from patients with persistent AF with rheumatic heart disease and non-AF myocardium with normal hearts were collected for circRNA differential expression analyses by high-throughput sequencing. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to predict the potential functions of the differentially expressed genes and AF-related pathways. Read More

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December 2018

The real-life data of hospitalized patients with heart failure: On behalf of the Journey HF-TR study investigators.

Anatol J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, Faculty of Medicine, İstanbul University, Institute of Cardiology; İstanbul-Turkey.

Objective: Acute heart failure (AHF) is a life-threatening clinical syndrome characterized by rapid onset of heart failure (HF) symptoms and signs and requires urgent therapy. The aim of the present study was to evaluate the overall clinical characteristics, management, and in-hospital outcomes of hospitalized patients with AHF in a large sample of Turkish population.

Methods: The Journey HF-TR study is a cross-sectional, multicenter, non-invasive and observational trial. Read More

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December 2018
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2D and 3D real-time passive cavitation imaging of pulsed cavitation ultrasound therapy in moving tissues.

Phys Med Biol 2018 Dec 6;63(23):235028. Epub 2018 Dec 6.

Institut Langevin, ESPCI ParisTech, CNRS UMR 7587, INSERM U979, Paris 7, 17 rue Moreau, 75012 Paris, France. Cardiawave SA, 29 rue du Faubourg Saint Jacques, 75014, Paris, France.

Pulsed cavitation ultrasound therapy (PCUT) is an effective non-invasive therapeutic approach in various medical indications that relies on the mechanical effects generated by cavitation bubbles. Even though limited by the poor contrast, conventional ultrasound B-Mode imaging has been widely used for the guidance and monitoring of the therapeutic procedure, allowing the visualization of the cavitation bubble cloud. However, the visualization of the bubble cloud is often limited in deep organs such as the liver and the heart and remains moreover completely subjective for the operator. Read More

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December 2018
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Interfacing a Potential Purely Organic Molecular Quantum Bit with a Real-Life Surface.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

By using a multidisciplinary and multi-technique approach, we have addressed the issue of attaching a molecular quantum bit to a real surface. First, we demonstrate that an organic derivative of the pyrene-Blatter radical is a potential molecular quantum bit. Our study of the interface of the pyrene-Blatter radical with a copper-based surface reveals that the spin of the interface layer is not cancelled by the interaction with the surface and that the Blatter-radical is resistant in presence of molecular water. Read More

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December 2018

Adherence, Persistence, Glycemic Control and Costs Among Patients with Type 2 Diabetes Initiating Dulaglutide Compared with Liraglutide or Exenatide QW at 12 Months Follow-Up in a US Real-World Setting.

Diabetes Obes Metab 2018 Dec 5. Epub 2018 Dec 5.

Lilly USA, LLC, Indianapolis, IN, USA.

Aims: This study evaluated adherence, persistence, glycemic control, and costs at 12 months follow-up for patients initiating dulaglutide vs liraglutide or exenatide QW.

Materials And Methods: This retrospective observational claims study included patients with type 2 diabetes (T2D) and ≥1 pharmacy claims for dulaglutide, liraglutide, or exenatide QW from HIRD®. Adherence was defined as proportion of days covered (PDC) ≥80%; persistence by time to discontinuation of index therapy. Read More

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December 2018

Caring for the older person with cognitive impairment in hospital: qualitative analysis of nursing personnel reflections on fall events.

J Clin Nurs 2018 Dec 5. Epub 2018 Dec 5.

School of Nursing & Midwifery and Menzies Health Institute Queensland, Griffith University and Gold Coast Hospital and Health Service, 2.05c, G01, Gold Coast Campus, Griffith University, Southport, Queensland.

Aims And Objectives: To explore nurse and nursing assistant reflections on the care of older patients with cognitive impairment who have experienced a fall.

Background: While there are evidence-based clinical guidelines for the prevention and management of falls and for the care of older people with cognitive impairment, the falls rates for older people with cognitive impairment is three times as high as those without.

Design: Critical incident technique. Read More

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December 2018
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A potential contribution of trappin-2 to the development of vasculopathy in systemic sclerosis.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Background: Trappin-2/pre-elafin is an endogenous inhibitor of human neutrophil elastase involved in inflammation, innate immunity and vascular remodeling, which consist of the complex pathological process of systemic sclerosis (SSc).

Objectives: To clarify the potential role of trappin-2 in SSc.

Methods: Serum trappin-2 levels were determined by enzyme-linked immunosorbent assay in 51 SSc and 18 healthy subjects. Read More

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December 2018
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Impact of image averaging on wide-field choroidal thickness measurements using enhanced-depth imaging optical coherence tomography.

Clin Exp Optom 2018 Dec 5. Epub 2018 Dec 5.

Contact Lens and Visual Optics Laboratory, School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia.

Background: The aim of this study was to examine the influence of B-scan averaging on choroidal thickness using wide-field enhanced-depth imaging optical coherence tomography.

Methods: Six high-resolution trans-foveal horizontal enhanced-depth imaging line scans (spanning a 60° field) were acquired consecutively from the right eye of 10 healthy adults (mean age 30 ± 5 years), with each line scan an average of 10, 20, 30, 40, 50 or 100 B-scans, using the automated real-time image averaging and follow-up features of a Spectralis device. The impact of B-scan averaging on regional measures of wide-field choroidal thickness (across macular and peripheral regions) and their accuracy was investigated, assuming that averaging 100 B-scans would provide the most accurate estimate of choroidal thickness. Read More

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December 2018

Knockdown of sal-like 4 expression by small interfering RNA induces apoptosis in breast cancer cells.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Biotechnology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.

Breast cancer is the most prevalent cancers worldwide and causes a significant amount of deaths annually. Spalt-like transcription factor 4 is known as a transcription factor, which has an important role in the proliferation of cancerous cells. Small interfering RNA (siRNA) is a short-chain molecule of 20 to 25 nucleotides that protrude on two sides of the 3', two nucleotides. Read More

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December 2018