6 results match your criteria Real Living with Multiple Sclerosis [Journal]

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Validity of the timed 25-foot walk as an ambulatory performance outcome measure for multiple sclerosis.

Mult Scler 2017 Apr 16;23(5):704-710. Epub 2017 Feb 16.

Multiple Sclerosis Outcome Assessments Consortium (MSOAC), Critical Path Institute, Tucson, AZ, USA.

The Multiple Sclerosis Outcome Assessments Consortium (MSOAC) includes representatives from advocacy organizations, Food and Drug Administration (FDA), European Medicines Agency (EMA), National Institute of Neurological Disorders and Stroke (NINDS), academic institutions, and industry partners along with persons living with multiple sclerosis (MS). One of the MSOAC goals is acceptance and qualification by regulators of performance outcomes that are highly reliable and valid, practical, cost-effective, and meaningful in MS. This article addresses the history, application, and psychometric properties of one such MSOAC metric of ambulation or walking namely, the timed 25-foot walk (T25FW). Read More

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http://dx.doi.org/10.1177/1352458517690823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405807PMC
April 2017
40 Reads

Identification and validation of clinically meaningful benchmarks in the 12-item Multiple Sclerosis Walking Scale.

Mult Scler 2017 Sep 7;23(10):1405-1414. Epub 2016 Dec 7.

Biogen, Cambridge, MA, USA.

Background: The 12-item Multiple Sclerosis Walking Scale (12-MSWS) is a validated questionnaire which assessed walking function; it has been widely adopted in multiple sclerosis (MS) clinical research.

Objective: Identify and validate clinically meaningful 12-MSWS benchmarks in MS.

Methods: Cross-sectional study of 159 MS patients permitted identification of clinically meaningful 12-MSWS benchmarks based on their relationship to real-life anchors. Read More

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http://dx.doi.org/10.1177/1352458516680749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411321PMC
September 2017
16 Reads

Distraction adds to the cognitive burden in multiple sclerosis.

Mult Scler 2017 01 11;23(1):106-113. Epub 2016 Jul 11.

Sunnybrook Health Sciences Centre, Department of Psychiatry, University of Toronto, Toronto, ON, Canada/University of Toronto, Toronto, ON, Canada.

Background: Cognitive dysfunction in multiple sclerosis (MS) causes numerous limitations in activities of daily living.

Objectives: To develop an improved method of cognitive assessment in people with MS using novel real-world distracters.

Methods: A sample of 99 people with MS and 55 demographically matched healthy controls underwent testing with the Minimal Assessment of Cognitive Functioning in Multiple Sclerosis (MACFIMS) and a modified version of the computerized Symbol Digit Modalities Test (c-SDMT). Read More

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http://dx.doi.org/10.1177/1352458516641208DOI Listing
January 2017
27 Reads

Perceived and actual arm performance in multiple sclerosis: relationship with clinical tests according to hand dominance.

Mult Scler 2013 Sep 13;19(10):1341-8. Epub 2013 Feb 13.

BIOMED Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.

Background: The real-life relevance of frequently applied clinical arm tests is not well known in multiple sclerosis (MS).

Objective: This study aimed to determine the relation between real-life arm performance and clinical tests in MS.

Methods: Thirty wheelchair-bound MS patients and 30 healthy controls were included. Read More

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http://dx.doi.org/10.1177/1352458513475832DOI Listing
September 2013
14 Reads

Predicting habitual walking performance in multiple sclerosis: relevance of capacity and self-report measures.

Mult Scler 2010 May 5;16(5):618-26. Epub 2010 Mar 5.

REVAL Rehabilitation and Health Care Research Centre, PHL University College, Hasselt, Belgium.

The objective was to establish the extent to which physical functioning capacity and self-report measures are able to predict the habitual walking performance in ambulatory persons with multiple sclerosis. Fifty persons with multiple sclerosis (Expanded Disability Status Scale, EDSS, 1.5-6. Read More

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http://dx.doi.org/10.1177/1352458510361357DOI Listing
May 2010
10 Reads

Constraint-Induced Movement therapy can improve hemiparetic progressive multiple sclerosis. Preliminary findings.

Mult Scler 2008 Aug 23;14(7):992-4. Epub 2008 Jun 23.

Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama 35249-7330, USA.

Objective: To evaluate whether Constraint-Induced Movement therapy (CI therapy) may benefit chronic upper extremity hemiparesis in progressive multiple sclerosis (MS).

Methods: Five patients with progressive MS, who had chronic upper extremity hemiparesis and evidence for learned non-use of the paretic limb in the life situation, underwent 30 hours of repetitive task training and shaping for the paretic limb over 2-10 consecutive weeks, along with physical restraint of the less-affected arm and a "transfer package" of behavioral techniques to reinforce treatment adherence.

Results: The patients showed significantly improved spontaneous, real-world limb use at post-treatment and 4 weeks post-treatment, along with improved fatigue ratings and maximal movement ability displayed in a laboratory motor test. Read More

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http://dx.doi.org/10.1177/1352458508090223DOI Listing
August 2008
5 Reads
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