210 results match your criteria Reactive Perforating Collagenosis


Trauma-induced acquired reactive perforating collagenosis.

An Bras Dermatol 2021 May-Jun;96(3):392-393. Epub 2021 Mar 20.

Patology Service, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

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Acquired Reactive Perforating Collagenosis: A Case Report.

Cureus 2021 Feb 27;13(2):e13583. Epub 2021 Feb 27.

Dermatology, Cheikh Khalifa International University Hospital, Mohammed VI University of Health Sciences, Casablanca, MAR.

Reactive perforating collagenosis (RPC) is a rare form of dermatosis. It forms with perforating folliculitis, Kyrle's disease, and serpiginous perforating elastosis, which is a group of perforating dermatosis. RPC can be hereditary with autosomal dominant transmission or it can be acquired, which is usually observed in diabetics with chronic renal failure. Read More

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February 2021

Necrotic plaques in an elderly male.

JRSM Open 2021 Feb 11;12(2):2054270420981452. Epub 2021 Feb 11.

Department of Dermatology, Ealing Hospital, Southall, UB1 3HW, UK.

Reactive perforating collagenosis is commonly recognised as an unusual form of transepithelial elimination of collagen and elastin fibres which are extruded through the epidermis in patients with a genetic predisposition or underlying diseases, such as diabetes mellitus or renal diseases. We present the unusual case of an 87-year-old diabetic male with a giant form of reactive perforating collagenosis and review the available literature. Read More

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February 2021

Dermoscopic Patterns of Acquired Reactive Perforating Collagenosis.

Dermatol Pract Concept 2021 Jan 7;11(1):e2020085. Epub 2020 Dec 7.

Department of Dermatology, Faculty of Medicine, Kirşehir Ahi Evran University, Kirşehir, Turkey.

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January 2021

Case of acquired reactive perforating collagenosis induced by panitumumab for colon cancer.

J Dermatol 2021 Feb 2;48(2):e114-e115. Epub 2020 Dec 2.

Department of Dermatological Oncology, National Cancer Center Hospital, Tokyo, Japan.

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February 2021

Reactive perforating collagenosis: a rare side effect associated with sorafenib.

Rev Esp Enferm Dig 2020 Dec;112(12):960-961

Dermatología, Hospital Universitario Príncipe de Asturias.

We present the case of a patient with a debut of reactive perforating collagenosis associated with the use of Sorafenib for stage IV hepatocarcinoma, very successfully controlled with local corticotherapy and systemic antihistamines. This is an extremely rare side effect associated with this treatment, as only another eleven cases of acquired perforating dermatoses associated with Sorafenib or other multi-kinase inhibitors have been found in the medical literature. Given the unusual nature of this presentation, high clinical suspicion and a correct histopathological study are indispensable for its correct filiation and treatment. Read More

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December 2020

Koebnerization of acquired reactive perforating collagenosis after wet cupping successfully treated with UVA1 phototherapy.

Dermatol Ther 2020 11 23;33(6):e14540. Epub 2020 Nov 23.

Department of Dermatology, Istanbul Medeniyet University Medical Faculty, Goztepe Training and Research Hospital, Istanbul, Turkey.

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November 2020

Reactive perforating collagenosis secondary to mesotherapy: first reported case.

J Biol Regul Homeost Agents 2020 Sep-Oct;34(5):1963-1965

Physical and Rehabilitation Medicine, Department of Clinical Sciences and Translational Medicine, Tor Vergata University, Rome, Italy.

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January 2021

Evaluation of clinicopathological and treatment characteristics of 80 patients with acquired perforating dermatosis.

Dermatol Ther 2020 11 5;33(6):e14465. Epub 2020 Nov 5.

Department of Pathology, University of Health Science (HSU) Istanbul Training and Research Hospital, Istanbul, Turkey.

Acquired perforating dermatosis (APD) is a group of a rare dermatological disorder characterized by elimination of dermal connective tissue through epidermis. We aimed to evaluate the characteristics of patients diagnosed with APD and to determine the differences in comorbidities according to subtypes of APD. A retrospective, observational, cross-sectional study was designed. Read More

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November 2020

Clinical practice guide for the treatment of perforating dermatosis.

J Dermatol 2020 Dec 23;47(12):1374-1382. Epub 2020 Oct 23.

Department of Dermatology, Juntendo University Urayasu Hospital, Urayasu, Japan.

Perforating dermatoses are a heterogeneous skin disease group defined by transepidermal elimination of various skin materials. Four classical forms of primary perforating dermatosis have been described, where the transepidermal elimination mechanism represents the hallmark of the disease: acquired reactive perforating collagenosis, elastosis perforans serpiginosa, Kyrle's disease and perforating folliculitis. Acquired reactive perforating collagenosis presents with transepidermal elimination of collagen fibers. Read More

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December 2020

Doxycycline Combined with NB-UVB Phototherapy for Acquired Reactive Perforating Collagenosis.

Ther Clin Risk Manag 2020 24;16:917-921. Epub 2020 Sep 24.

Department of Dermatology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, People's Republic of China.

Background: Acquired reactive perforating collagenosis is a rare skin disease characterized by the discharge of collagen fibers through the epidermis. There is no standard treatment for this disease currently. Here, we report a case of ARPC that has been successfully treated and cured. Read More

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September 2020

Case for diagnosis. Hyperpigmented and excoriated papules and nodules in a diabetic patient.

An Bras Dermatol 2020 Nov - Dec;95(6):757-759. Epub 2020 Sep 13.

Department of Pathology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

Reactive perforating collagenosis is a rare perforating dermatosis clinically characterized by intensely pruritic hyperpigmented papules, plaques, and nodules with a central keratotic plug. Histopathology reveals transepidermal elimination of collagen fibers. Its pathophysiology is still under investigation, but the acquired form has been linked to systemic conditions such as diabetes mellitus and chronic kidney disease. Read More

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November 2020

Acquired Reactive Perforating Collagenosis Associated with Linear Immunoglobulin A Bullous Disease.

Acta Derm Venereol 2020 Sep 23;100(16):adv00268. Epub 2020 Sep 23.

Department of Dermatology, Children's Hospital of Chongqing Medical University, 400014 ChongQing, China. E-mail:

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September 2020

Acquired reactive perforating collagenosis in association with pregnancy.

Eur J Obstet Gynecol Reprod Biol 2020 Oct 1;253:339-341. Epub 2020 Aug 1.

Department of Dermatology, St Helens and Knowsley Teaching Hospitals NHS Trust, Marshalls Cross Road, St Helens, WA9 3DA, United Kingdom. Electronic address:

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October 2020

Reactive Perforating Collagenosis; An Uncontrolled Pruritus That Left You Scratching Your Head.

Cureus 2020 Jul 14;12(7):e9175. Epub 2020 Jul 14.

Internal Medicine, State University of New York Upstate Medical University, Syracuse, USA.

Acquired perforating collagenosis is a rare disease of altered collagen formation that is extruded through the epidermis. It is most commonly seen in patients with microvascular disease including longstanding diabetes and chronic kidney disease (CKD). Due to the rarity of the disease, no large randomized clinical studies have been performed to determine the most efficacious method of treatment. Read More

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Acquired reactive perforating collagenosis with chondrodermatitis nodularis chronica helicis.

J Dermatol 2020 Oct 30;47(10):e362-e364. Epub 2020 Jul 30.

Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

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October 2020

Acquired Reactive Perforating Collagenosis.

Clin Exp Nephrol 2020 Nov 14;24(11):1086-1087. Epub 2020 Jul 14.

Divison of Nephrology, University of Utah, Salt Lake City, UT, 84132, USA.

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November 2020

Acquired reactive perforating collagenosis.

Chin Med J (Engl) 2020 Sep;133(17):2119-2120

Department of Dermatology, Peking University People's Hospital, Beijing 100044, China.

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September 2020

Berardinelli-Seip Syndrome and Essential Thrombocytosis: An Unusual Association.

Oman Med J 2020 May 30;35(3):e135. Epub 2020 Jun 30.

Department of Internal Medicine, Endocrine Division, King Hussein Medical Centre, Amman, Jordan.

Congenital generalized lipodystrophy (Berardinelli-Seip syndrome) is an autosomal recessive condition, presenting during infancy with generalized loss of fat. We report a 30-year-old female patient with diabetes who has acromegaloid features, prominent umbilicus, prominent muscles, prominent subcutaneous veins, and gross hepatomegaly. Near-total loss of subcutaneous fat was confirmed by whole-body magnetic resonance imaging and laboratory data revealed significant hypertriglyceridemia, uncontrolled diabetes mellitus, and heavy proteinuria with stage IIIa chronic kidney disease. Read More

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Reflectance confocal microscopic appearance of acquired reactive perforating collagenosis.

Skin Res Technol 2021 Jan 28;27(1):111-112. Epub 2020 Jun 28.

Department of Pathology, Hospital for Skin Disease and Institute of Dermatology, Peking Union Medical College & Chinese Academy of Medical Sciences, Nanjing, China.

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January 2021

Acquired reactive perforating collagenosis: A case report and review of the literature.

Medicine (Baltimore) 2020 May;99(22):e20391

Division of Endocrinology, Tongji Hospital, Huazhong University of Science and Technology.

Introduction: Acquired reactive perforating collagenosis (ARPC) is a rare skin disorder, which is associated with various internal diseases and even malignant neoplasms. A comprehensive knowledge of the concomitant diseases in ARPC patients is helpful to decrease the misdiagnosis. Although the treatment of ARPC is challenging, systemic assessment of existing regimens is not available. Read More

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Acquired reactive perforating collagenosis in association with prostate adenocarcinoma, chronic lymphocytic leukemia, and Graves' disease.

An Bras Dermatol 2020 May - Jun;95(3):336-339. Epub 2020 Apr 18.

Department of Dermatology and Venerology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Acquired reactive perforating collagenosis is a rare skin disorder characterized by the presence of umbilicated pruritic papules and nodules. Transepidermal elimination of altered and perforating bundles of basophilic collagen from the epidermis is a characteristic histologic feature of acquired reactive perforating collagenosis. Along with its well-known association with systemic diseases such as diabetes mellitus, chronic renal failure, and dermatomyositis, there are reports of acquired reactive perforating collagenosis being associated with malignancies. Read More

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Crateriform plaques in a patient with end-stage renal disease. The case of an acquired reactive perforating collagenosis.

Nefrologia (Engl Ed) 2020 May - Jun;40(3):358-360. Epub 2019 Jul 24.

Servicio de Dermatología, Hospital Regional Licenciado Adolfo López Mateos, ISSSTE, Ciudad de México, México.

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Reactive Perforating Collagenosis in End-Stage Renal Disease: Not All that Itches Is Uremic Pruritis!

Am J Med 2019 08 3;132(8):e658-e660. Epub 2019 Apr 3.

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville; Division of Nephrology, University of Texas Health, San Antonio.

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Unusual eruption in association with sorafenib: a case of acquired perforating dermatosis, reactive perforating collagenosis type.

Dermatol Online J 2018 Dec 15;24(12). Epub 2018 Dec 15.

New York University Langone Medical Center, The Ronald O. Perelman Department of Dermatology, New York, New York.

The term, acquired perforating dermatoses (APD), represents a group of skin conditions that develop in adulthood and are characterized by transepidermal elimination of dermal connective tissue. This appears clinically as a papulonodule with a keratotic core. Although APD is typically associated with diabetes mellitus, chronic renal failure, and several other conditions causing generalized pruritus, there have been reports in the literature describing an association of APD with select drugs including sorafenib. Read More

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December 2018

Acquired perforating collagenosis associated with ranibizumab injection and succesfully switched to aflibercept.

GMS Ophthalmol Cases 2018 13;8:Doc06. Epub 2018 Dec 13.

Istanbul Sağlık Bilimleri University Ümraniye Training and Research Hospital, Department of Pathology, Istanbul, Turkey.

To report a case of acquired reactive perforating collagenosis (ARPC) triggered by an intravitreal ranibizumab injection that was successfully treated by switching to aflibercept (AFL). A 73-year-old Caucasian man with an occult choroidal neovascular membrane in the right eye received three-monthly intravitreal ranibizumab injections. Two weeks after the second ranibizumab injection, he complained about a generalized, excessively pruriginous eruption that was further exacerbated by the third injection. Read More

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December 2018

Reactive Perforating Collagenosis.

Authors:
Jean Kanitakis

Skinmed 2018;16(6):390-396. Epub 2018 Dec 21.

From the Department of Dermatology, Ed. Herriot Hospital Group, Lyon, France;

Reactive perforating collagenosis (RPC) is a rare disease belonging to the spectrum of primary perforating dermatoses. It manifests clinically with brown-erythematous papules with a central plug that develop after minor skin trauma, and it is characterized histologically by epidermal perforation and transepidermal elimination of altered dermal collagen. Familial and acquired forms have been described, the latter usually associated with systemic diseases, among which diabetes mellitus and renal failure are the most common. Read More

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October 2019