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    173 results match your criteria Reactive Perforating Collagenosis

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    Reactive perforating collagenosis: An important differential diagnosis in hemodialysis patients.
    Saudi J Kidney Dis Transpl 2018 Mar-Apr;29(2):422-425
    Department of Nephrology, Apollo Gleneagles Hospitals, Kolkata, West Bengal, India.
    This is a case report of a 68-year-old hypertensive, diabetic woman who was on regular thrice weekly hemodialysis (HD). She presented with gradually worsening left lower limb pain and swelling. Clinical examination revealed significant edema over the left calf and ankle joint with significant calf tenderness. Read More

    Dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid in a patient with acquired reactive perforating collagenosis.
    J Dermatol 2018 May 14;45(5):600-602. Epub 2018 Feb 14.
    Department of Dermatology, Jichi Medical University Saitama Medical Center, Saitama, Japan.
    Bullous pemphigoid (BP) is a common autoimmune blistering disorder with unknown etiology. Recently, increasing numbers of BP cases which developed under the medication with dipeptidyl peptidase-4 inhibitors (DPP4i), widely used antihyperglycemic drugs, have been reported in published works. Here, we report a case of DPP4i (teneligliptin)-associated BP that developed in a 70-year-old Japanese man. Read More

    Expression of the receptor for advanced glycation end products in acquired reactive perforating collagenosis.
    Indian J Dermatol Venereol Leprol 2017 Jul-Aug;83(4):432-435
    Department of Dermatovenereology, Ataturk Training and Research Hospital, Ankara, Turkey.
    Background: Acquired reactive perforating collagenosis (ARPC) is a rare skin disorder characterized by transepidermal elimination of dermal collagen. There is little data regarding the pathogenesis of ARPC. The receptor for advanced glycation end products (RAGE) is a multiligand transmembrane receptor that plays an important role in inflammatory responses and may be involved in the pathogenesis of ARPC. Read More

    Acquired perforating dermatosis in a patient with chronic renal failure.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):10-13
    Universidade Federal do Estado do Rio de Janeiro (UNIRIO) - Rio de Janeiro (RJ), Brazil.
    Perforating dermatoses are a group of skin diseases characterized by transepidermal elimination of dermal material. The disease is divided into two groups: the primary group and the secondary group. The classical or primary perforating dermatoses are subdivided into four types according to the eliminated dermal materials: Kyrle disease, perforating reactive collagenosis, elastosis perforans serpiginosa, and perforating folliculitis. Read More

    Acquired perforating dermatosis: clinicopathological study of 31 cases, emphasizing pathogenesis and treatment.
    J Eur Acad Dermatol Venereol 2017 Oct 10;31(10):1757-1763. Epub 2017 Apr 10.
    Unit of Dermatology, Hospital San Jorge, Huesca, Spain.
    Background: Acquired perforating dermatosis (APD) is a rare group of skin disorders of unknown aetiology and pathogenesis and is associated with several systemic diseases.

    Objective: We review the clinicopathological features, associated systemic diseases and treatment response in a series of APD patients.

    Methods: We conducted a retrospective observational study of all patients histologically diagnosed with APD in Hospital San Jorge (Huesca, Spain) between 2002 and 2014. Read More

    A case of rheumatoid vasculitis with acquired reactive perforating collagenosis.
    Mod Rheumatol 2016 Nov 23:1-4. Epub 2016 Nov 23.
    b Department of Human Pathology , Wakayama Medical University Graduate School of Medicine , Wakayama , Japan.
    A 55-year-old man with rheumatoid arthritis (RA) presented hyperkeratotic erythematous papules with crusts or blisters on his limbs and buttocks. A histological study showed acquired reactive perforating collagenosis. Soon, skin lesions changed to umbilicated lesions with black necrosis, and the scar from his skin biopsy ulcerated with induration due to rheumatoid vasculitis. Read More

    Acquired reactive perforating collagenosis: A report of a typical case.
    Medicine (Baltimore) 2016 Jul;95(30):e4305
    Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
    Background: Reactive perforating collagenosis (RPC) is a rare form of transepithelial elimination, in which altered collagen is extruded through the epidermis. There are 2 types of RPC, acquired RPC (ARPC) and inherited RPC, while the latter is extremely rare. Here we report on 1 case of ARPC. Read More

    Rev Enferm 2016 Apr;39(4):31-4
    The dermatosis known since reactive perforating collagenosis (RPC) is an injury that is characterized by the transepidermal elimination of the collagen. Two forms of presentation exist: the inherited one and the acquired one. The acquired form appears in the adult age, principally in diabetics with renal chronic insufficiency. Read More

    Acquired reactive perforating collagenosis and pseudoporphyric bullous dermatosis in a hemodialysis patient.
    Hemodial Int 2016 Jul 2;20(3):E14-E18. Epub 2016 Feb 2.
    Department of Pathology, General Hospital Hippokrateion, Thessaloniki, Greece.
    Hemodialysis patients present with a broad spectrum of specific and nonspecific skin disorders, which rarely coexist. We report an exceptional case of a hemodialysis patient that developed acquired reactive perforating collagenosis and pseudoporphyric bullous dermatosis on the basis of common skin disorders which include hyperpigmentation, pruritus, xerosis cutis, and Linsday's nails. Interestingly, our patient presented with two unusual but distinctive cutaneous dermopathies on the background of other commonly seen skin alterations. Read More

    [Acquired perforating dermatosis in the patient with chronic kidney disease – case report and literature review].
    Przegl Lek 2016;73(9):680-3
    Acquired perforating dermatosis (APD) represents a heterogenous group of skin disorders characterized histopathologically by transepithelial elimination (TEE) of dermal structures. APD is manifested clinically as multi-localized, papulo-nodular skin lesions accompanied by a refractory pruritus. APD typically coexists with long-term disorders, most often diabetic kidney disease (DKD). Read More

    Dermatomyositis, clinically presenting with cutaneous ulcers, with histopathologic evidence of perforating collagenosis.
    Dermatol Online J 2016 Dec 15;22(12). Epub 2016 Dec 15.
    Ronald O. Perelman Department of Dermatology, NYU School of Medicine, NYU Langone Medical Center.
    Dermatomyositis is a systemic, autoimmune diseasewith a variety of clinical features that often includemyositis and characteristic cutaneous findings. Asubset of patients with dermatomyositis developcutaneous ulcers, often in the setting of vasculitis orvasculopathy. We present a case of dermatomyositiswith cutaneous ulcers that show perforatingcollagenosis on histopathologic examination. Read More

    Pseudoperforation: an uncommon histologic phenomenon in prurigo misleading for the diagnosis of reactive perforating collagenosis.
    Pathol Res Pract 2014 Dec 27;210(12):1043-8. Epub 2014 Jun 27.
    Department of Dermatology, Al-Azhar University, Dumyat, Egypt.
    Prurigo is a common skin condition characterized by vigorous scratching. Although ulceration is not uncommon in prurigo, a perforating-like lesion was not previously reported. In this study we described series of cases of prurigo with perforating-like lesions and discussed its relation to acquired perforating dermatoses. Read More

    Familial reactive perforating collagenosis: a report of two cases.
    Indian J Dermatol 2014 May;59(3):287-9
    Department of Dermatology, SDM College of Medical Sciences and Hospital, Sattur, Dharwad, Karnataka, India.
    Reactive perforating collagenosis (RPC) is a rare form of transepithelial elimination, in which genetically altered collagen is extruded through the epidermis. Of the acquired and inherited form, inherited form is extremely rare. Here, we present two cases of inherited form of RPC in a family. Read More

    A clinicopathologic study of thirty cases of acquired perforating dermatosis in Korea.
    Ann Dermatol 2014 Apr 30;26(2):162-71. Epub 2014 Apr 30.
    Department of Dermatology, Eulji General Hospital, Eulji University, Seoul, Korea.
    Background: Acquired perforating dermatosis (APD) is histopathologically characterized by transepidermal elimination of materials from the upper dermis. APD can be divided into four diseases: Kyrle's disease, perforating folliculitis, elastosis perforans serpiginosa, and reactive perforating collagenosis. APD is usually associated with systemic diseases, especially diabetes mellitus or chronic renal failure. Read More

    Perforating disorders of the skin.
    Indian J Pathol Microbiol 2013 Oct-Dec;56(4):355-8
    Department of pathology, K. J. Somaiya Medical College and Research Centre, Mumbai, Maharashtra, India.
    Background: Perforating disorders of the skin, is an often overlooked entity characterized by transepidermal elimination of material from the upper dermis and are classified histopathologically according to the type of epidermal disruption and the nature of the eliminated material. They include Kyrle's disease, perforating folliculitis, reactive perforating collagenosis, and elastosis perforans serpiginosa.

    Aim: The aim of this study was to delineate the clinical and histopathological features of perforating disorders of the skin. Read More

    A rare case of familial reactive perforating collagenosis.
    Indian J Dermatol 2013 Sep;58(5):408
    Department of Dermatology, Command Hospital, Pune, India.
    A 4 year old boy presented with history of itchy raised lesions on body of 2 years duration. Though parental consanguinity was not present, his elder brother had similar complaints. Dermatological examination revealed multiple hyperpigmented papules with a central keratotic plug distributed mainly over face and extensors of upper and lower extremities. Read More

    Acquired reactive perforating dermatosis.
    J Dtsch Dermatol Ges 2013 Aug 29;11(8):723-9, 723-30. Epub 2013 May 29.
    Department of Dermatology, Allergology, and Phlebology, Bremerhaven Reinkenheide Hospital, Germany.
    Acquired reactive perforating dermatosis is characterized by umbilicated erythematous papules and plaques with firmly adherent crusts. Histopathological examination shows a typical cup-shaped ulceration in the epidermis containing cellular debris and collagen. There is transepidermal elimination of degenerated material with basophilic collagen bundles. Read More

    Allopurinol in the treatment of acquired reactive perforating collagenosis.
    An Bras Dermatol 2013 Jan-Feb;88(1):94-7
    Department of Dermatology, Division of General Dermatology, Medical University of Graz, Graz, Austria.
    Acquired reactive perforating collagenosis is a perforating dermatosis usually associated with different systemic diseases, mainly diabetes mellitus and/or chronic renal insufficiency. Different therapies have been tried but treatment is not standardized yet and remains a challenge. In the last few years, allopurinol has been reported as a good therapeutic option for acquired reactive perforating collagenosis. Read More

    [Reactive perforating collagenosis].
    Ann Dermatol Venereol 2012 Jun 30;139(6-7):481-5. Epub 2012 May 30.
    Service de dermatologie, hôpital central de l'Armée Ain Naadja (HCA), Kouba 16000 Alger, Algérie. salhi
    Background: Reactive perforating collagenosis (RPC) belongs to the group of perforating dermatoses, which comprises elastosis perforans serpiginosa, RPC, perforating folliculitis and Kyrle's disease. RPC was initially described as a distinctive form of transepithelial elimination of altered collagen related to superficial trauma. Two types are distinguished: a hereditary type (MIM 216700), which is rare and begins during early childhood, and a second type, called acquired RPC, which is more frequent, appears in adults and is associated with other diseases, diabetes mellitus, renal insufficiency, solid tumors, lymphomas and AIDS. Read More

    Familial reactive perforating collagenosis in a child: response to narrow-band UVB.
    Pediatr Dermatol 2013 Nov-Dec;30(6):762-4. Epub 2012 Apr 4.
    Dermato-Venereology (Skin/VD) Center, Sehgal Nursing Home, Panchwati-Delhi, Department of Dermatology and STDDepartment of Pathology, University College of Medical Sciences, and Associated Guru Teg Bahadur Hospital, Shahdara, Delhi, India.
    A favorable response to narrow-band ultraviolet B light treatment, a novel option, is illustrated in familial reactive perforating collagenosis, and its use is recommended. Its probable mode of action is outlined. Read More

    Acquired reactive perforating collagenosis.
    Eurasian J Med 2012 Apr;44(1):51-3
    Department of Pathology, Konya Education and Research Hospital, Konya, Turkey.
    Acquired reactive perforating collagenosis (ARPC) is commonly recognized as an unusual skin reaction to superficial trauma that is observed in patients with a certain genetic predisposition or underlying diseases, such as diabetes mellitus or renal diseases. We present the unusual case of a 55-year-old female diabetic patient with numerous characteristic dome-shaped nodules, which consisted of central umbilication containing firm keratotic plugs. Read More

    Kyrle disease and acquired perforating collagenosis secondary to chronic renal failure and diabetes mellitus.
    Case Rep Dermatol 2011 Sep 29;3(3):209-11. Epub 2011 Sep 29.
    Department of Dermatology, University Hospital Regensburg, Regensburg.
    A 59-year-old man with chronic renal failure and diabetes mellitus presented with pruritic crusted lesions which histologically were perforating disorders, showing features of both Kyrle disease and acquired perforating collagenosis. The mechanisms of transepidermal elimination and the classification of perforating disorders are briefly discussed. Additionally, we question the concept of perforation, as epidermal damage and exposure of subepidermal substances may artificially present as perforation. Read More

    [Acquired reactive perforating collagenosis following herpes zoster as isotopic response?].
    Hautarzt 2011 Sep;62(9):683-7
    Klinik für Dermatologie, Venerologie und Allergologie, Ruhr-Universität Bochum, Bochum, Deutschland.
    Reactive perforating collagenosis is a disease whose pathogenesis is still not fully understood. Histological findings are degenerated collagen bundles which are arranged in vertical direction penetrating the epidermis into a dome-shaped crater. Usually diabetes mellitus and renal failure can be found among patients with reactive perforating collagenosis. Read More

    [Acquired reactive perforating collagenosis: report of two cases].
    Rev Med Chil 2010 Oct 10;138(10):1281-4. Epub 2011 Jan 10.
    Departamentos de Dermatología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile.
    Acquired reactive perforating collagenosis is a perforating dermatosis characterized by transepidermal elimination of collagen. It is frequently associated to diabetes mellitus and chronic renal insufficiency, but it is also related to other systemic diseases. The lesions tend to resolve once the underlying condition is treated. Read More

    Acquired reactive perforating collagenosis: current status.
    J Dermatol 2010 Jul;37(7):585-92
    Department of Dermatology, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
    Acquired reactive perforating collagenosis is a unique perforating dermatosis, characterized clinically by umbilicated hyperkeratotic papules or nodules and histologically by a focal hyperkeratosis in direct contact with transepidermal perforating dermal collagen. Several inflammatory or malignant systemic diseases may coexist with acquired reactive perforating collagenosis. The possible biochemical or immunological mechanisms of the systemic diseases, potentially responsible for the development and appearance of acquired reactive perforating collagenosis, are still under investigation. Read More

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