1,523 results match your criteria Reactive Arthritis Imaging


Managing of musculoskeletal infections in children.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):179-186

Department of Orthopaedics and Traumatology, Institute of Scientific Research, Children's Hospital Bambino Gesù, Rome, Italy.

Objective: Epidemiological features of musculoskeletal infections are in continuous evolution. The incidence of emerging causative pathogen is arising. Nevertheless, up to 50% of osteoarticular infections shows negative cultures. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17488DOI Listing

What potential do magnetic iron oxide nanoparticles have for the treatment of rheumatoid arthritis?

Authors:
Lin Wu Song Shen

Nanomedicine (Lond) 2019 Apr 29;14(8):927-930. Epub 2019 Mar 29.

Department of Pharmaceutics, School of Pharmaceutical Science, Jiangsu University, Zhenjiang 212013, China.

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http://dx.doi.org/10.2217/nnm-2019-0071DOI Listing
April 2019
1 Read

Evolving patterns of reactive arthritis.

Clin Rheumatol 2019 Mar 27. Epub 2019 Mar 27.

Department of Medicine, Schulich School of Medicine & Dentistry, Western University, London, Canada.

Objective: To characterize rheumatologists' perspectives on evolving trends of reactive arthritis (ReA).

Methods: After ethics approval, 548 members of the Canadian Rheumatology Association were surveyed with 37 questions covering their demographic information, subspecialty, level of experience, practice setting and opinions on prevalence, treatment, and causes of ReA. Results were analyzed with descriptive statistics. Read More

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http://dx.doi.org/10.1007/s10067-019-04522-4DOI Listing
March 2019
1 Read

Evaluation and Management of Septic Arthritis and its Mimics in the Emergency Department.

West J Emerg Med 2019 Mar 6;20(2):331-341. Epub 2018 Dec 6.

Rush University Medical Center, Department of Emergency Medicine, Chicago, Illinois.

Septic arthritis is a dangerous medical condition associated with significant morbidity and mortality. However, the differential diagnosis can be broad with conditions that mimic this disease and require different evaluation and treatment. This narrative review presents the emergency medicine evaluation and management, as well as important medical conditions that may mimic this disease. Read More

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http://dx.doi.org/10.5811/westjem.2018.10.40974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404712PMC
March 2019
1 Read

ERAMRS: a new MR scoring system for early rheumatoid arthritis of the wrist.

Eur Radiol 2019 Mar 14. Epub 2019 Mar 14.

Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, N.T., Hong Kong.

Purpose: To (i) devise a new semi-quantitative scoring system known as Early Rheumatoid Arthritis Magnetic Resonance Score (ERAMRS) to assess inflammation of the wrist on magnetic resonance imaging in early rheumatoid arthritis and to (ii) test ERAMRS and other MR scoring systems against everyday used clinical scorings.

Materials And Methods: One hundred six treatment-naïve patients (81 females, 25 males, mean age 53 ± 12 years) with early rheumatoid arthritis (ERA) underwent clinical/serological testing as well as 3-T MRI examination of the most symptomatic wrist. Clinical assessment included Disease Activity Score-28 and Health Assessment Questionnaire; erythrocyte sedimentation rate and C-reactive protein were measured. Read More

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http://dx.doi.org/10.1007/s00330-019-06060-8DOI Listing
March 2019
3 Reads

Back pain following instillations of BCG for superficial bladder cancer is not a reactive complication: review of 30 Mycobacterium bovis BCG vertebral osteomyelitis cases.

Clin Rheumatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Rheumatology, Centre Hospitalier Universitaire de Rennes, 35000, Rennes, France.

Mycobacterium bovis Bacillus Calmette-Guérin (BCG) instillations are used in bladder cancer treatment. Adverse effects can occur. Osteoarticular complications are mainly reactive arthritis, but true infections have been described, such as vertebral osteomyelitis. Read More

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http://dx.doi.org/10.1007/s10067-019-04500-wDOI Listing
March 2019
1 Read

Relationship between Prolidase Activity and Atrial Electromechanical Changes in Patients with Paroxysmal Atrial Fibrillation.

Comb Chem High Throughput Screen 2019 Mar 6. Epub 2019 Mar 6.

Department of Cardiology, Harran University Faculty of Medicine, Sanliurfa. Turkey.

Background: Tissue fibrosis increases in the structure of the atrial tissue of atrial fibrillation patients. Prolidase enzyme regulates collagen synthesis. There may be an association between electrocardiography (ECG) findings and prolidase activity. Read More

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http://dx.doi.org/10.2174/1386207322666190306143317DOI Listing
March 2019
6 Reads

The challenge of differentiating vaso-occlusive crises from osteomyelitis in children with sickle cell disease and bone pain: A 15-year retrospective review.

J Child Orthop 2019 Feb;13(1):33-39

Trauma and Orthopaedic Department, St George's Hospital, London, UK.

Purpose: The paediatric sickle cell disease (SCD) osteomyelitis (OM) incidence is 0.3% to 12%. Differentiating vaso-occlusive crises (VOC) from OM is a diagnostic challenge, with limited evidence guiding management. Read More

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http://dx.doi.org/10.1302/1863-2548.12.180094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376437PMC
February 2019
3 Reads

Radiographic Progression According to Baseline C-reactive Protein Levels and Other Risk Factors in Psoriatic Arthritis Patients Treated with Tofacitinib or Adalimumab.

J Rheumatol 2019 Mar 1. Epub 2019 Mar 1.

From the Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Department of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada; Department of Rheumatology, St Vincent's University Hospital, Dublin, Ireland; Division of Rheumatology, Allergy, and Immunology, University of California, San Diego School of Medicine, La Jolla, San Diego, California, USA; Pfizer Inc, Groton, Connecticut, USA; Pfizer Inc, Montreal, QC, Canada. This study was funded by Pfizer Inc. DvdH has received consultancy fees from AbbVie, Amgen, Astellas, AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Daiichi, Eli Lilly, Galapagos, Gilead, GlaxoSmithKline, Janssen, Merck, Novartis, Pfizer Inc, Regeneron, Roche, Sanofi, Takeda, and UCB; and is the Director of Imaging Rheumatology BV. DDG has received research grants and consultancy fees from AbbVie, Amgen, Bristol-Myers Squibb, Celgene, Eli Lilly, Janssen, Novartis, Pfizer Inc, and UCB; and has received consultancy fees from AbbVie, Amgen, Bristol-Myers Squibb, Celgene, Eli Lilly, Janssen, Novartis, Pfizer Inc, and UCB. OF has received research grants and consultancy fees from AbbVie, Bristol- Myers Squibb, Novartis, and Pfizer Inc; and has received consultancy fees from Amgen, Celgene, Eli Lilly, and Janssen. AK has received consultancy fees or other remuneration from Pfizer Inc. DG, CW, and LF are employees and shareholders of Pfizer Inc. Pfizer Inc were involved in the design of the study, collection, analysis, and interpretation of data, and review and approval of the manuscript. Address correspondence to: Professor Désirée van der Heijde, Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. E-mail:

Objective: To evaluate the effect of baseline risk factors on radiographic progression in patients with active psoriatic arthritis (PsA) and an inadequate response to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) treated with tofacitinib or adalimumab.

Methods: Tofacitinib is an oral Janus kinase inhibitor for the treatment of PsA. OPAL Broaden (NCT01877668) was a 12-month, double-blind phase III trial. Read More

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http://dx.doi.org/10.3899/jrheum.180971DOI Listing
March 2019
4 Reads

Treat-to-target in rheumatoid arthritis: Evaluating the patient perspective using the Patient Opinion Real-Time Anonymous Liaison system: The RA T2T PORTAL study.

Int J Rheum Dis 2019 Feb 22. Epub 2019 Feb 22.

Department of Medicine, University of Otago, Wellington, New Zealand.

Objectives: To determine the level of agreement among patients with rheumatoid arthritis (RA) with the principles and recommendations of the treat-to-target (T2T) initiative in New Zealand (NZ) and to further explore specific patient opinions via online iterative surveys.

Methods: Participants with RA were recruited from rheumatology clinics in NZ and invited to receive and reply to surveys administered via the Patient Opinion Real-Time Anonymous Liaison (PORTAL) system. An enrolment survey recorded demographics, disease duration and treatment and then RA T2T surveys were administered weekly. Read More

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http://dx.doi.org/10.1111/1756-185X.13514DOI Listing
February 2019
1 Read

Release of Amino- or Carboxy-Containing Compounds Triggered by HOCl: Application for Imaging and Drug Design.

Angew Chem Int Ed Engl 2019 Mar 6;58(14):4547-4551. Epub 2019 Mar 6.

Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai, 200438, China.

The overproduction of HOCl is highly correlated with diseases such as atherosclerosis, rheumatoid arthritis, and cancer. Whilst acting as a marker of these diseases, HOCl might also be used as an activator of prodrugs or drug delivery systems for the treatment of the corresponding disease. In this work, a new platform of HOCl probes has been developed that integrates detection, imaging, and therapeutic functions. Read More

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http://dx.doi.org/10.1002/anie.201813648DOI Listing
March 2019
23 Reads

Effect of Magnetic Resonance Imaging vs Conventional Treat-to-Target Strategies on Disease Activity Remission and Radiographic Progression in Rheumatoid Arthritis: The IMAGINE-RA Randomized Clinical Trial.

JAMA 2019 02;321(5):461-472

Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.

Importance: Whether using magnetic resonance imaging (MRI) to guide treatment in patients with rheumatoid arthritis (RA) improves disease activity and slows joint damage progression is unknown.

Objective: To determine whether an MRI-guided treat-to-target strategy vs a conventional clinical treat-to-target strategy improves outcomes in patients with RA in clinical remission.

Design, Setting, And Participants: Two-year, randomized, multicenter trial conducted at 9 hospitals in Denmark. Read More

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http://dx.doi.org/10.1001/jama.2018.21362DOI Listing
February 2019
4 Reads

Hypertrophic cervical spine pachymeningitis due to sarcoidosis: a case report.

Hosp Pract (1995) 2019 Apr 6;47(2):99-103. Epub 2019 Feb 6.

d Pathology , Lehigh Valley Health Network , Allentown , PA , USA.

Hypertrophic pachymeningitis (HP) is a chronic, progressive diffuse inflammatory condition that leads to thickening of the dura mater and can be idiopathic or associated with sarcoidosis among other disorders. In this case report, we present a rare case of cervical spine HP in a 29-year-old woman in the post-partum period, who had a history of pituitary adenoma and juvenile rheumatoid arthritis. Magnetic resonance imaging (MRI) of the spine revealed a soft tissue mass and moderate cord compression. Read More

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https://www.tandfonline.com/doi/full/10.1080/21548331.2019.1
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http://dx.doi.org/10.1080/21548331.2019.1575645DOI Listing
April 2019
14 Reads

Clinical course and prognostic factors of childhood Takayasu's arteritis: over 15-year comprehensive analysis of 101 patients.

Arthritis Res Ther 2019 Jan 22;21(1):31. Epub 2019 Jan 22.

State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Childhood Takayasu's arteritis (c-TA) is scarcely reported but is characterized by devastating morbidity and mortality. This study aims to investigate the clinical course of c-TA and prognostic factors associated with rehospitalization and events including vascular complications, flares, and death.

Methods: An ambispective study of 101 c-TA patients satisfying the American College of Rheumatology (ACR) criteria and/or the European League against Rheumatism (EULAR)/Pediatric Rheumatology International Trials Organization (PRINTO)/Pediatric Rheumatology European Society (PReS) criteria was conducted from January 2002 to December 2017. Read More

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http://dx.doi.org/10.1186/s13075-018-1790-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341556PMC
January 2019
1 Read

A Phase 2 Trial of Lutikizumab, an Anti-Interleukin 1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis.

Arthritis Rheumatol 2019 Jan 17. Epub 2019 Jan 17.

AbbVie Inc., North Chicago, IL, United States.

Objective: To assess the efficacy and safety of the anti-interleukin (IL)-1α/β dual variable domain immunoglobulin lutikizumab (ABT-981) in subjects with knee osteoarthritis (OA) and evidence of synovitis.

Methods: Subjects (N=350; 347 analyzed) with Kellgren-Lawrence grade 2-3 knee OA and synovitis (determined by magnetic resonance imaging [MRI] or ultrasound) were randomized to placebo or lutikizumab 25, 100 or 200 mg subcutaneously every 2 weeks for 50 weeks. The co-primary endpoints were change from baseline in Western Ontario and McMaster Universities Osteoarthritis (WOMAC) pain index at week 16 and change from baseline in MRI synovitis at week 26. Read More

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http://doi.wiley.com/10.1002/art.40840
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http://dx.doi.org/10.1002/art.40840DOI Listing
January 2019
11 Reads

The value of the simplified RAMRIS-5 in early RA patients under methotrexate therapy using high-field MRI.

Arthritis Res Ther 2019 Jan 14;21(1):21. Epub 2019 Jan 14.

Department and Hiller Research Unit for Rheumatology, UKD, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, 40225, Düsseldorf, Germany.

Background: The aim of the study was to evaluate a simplified version of the Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) for five joints of the hand (RAMRIS-5) in patients with early rheumatoid arthritis (RA) before and after the initiation of methotrexate (MTX) therapy using high-resolution, 3-T magnetic resonance imaging (MRI).

Methods: Twenty-eight patients with a seropositive, early RA (disease duration of less than 6 months (range 2-23 weeks)) according to 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria (mean age 56.8 years, range 39-74) were prospectively assessed with a baseline investigation including clinical assessment (disease activity score of 28 joints (DAS-28) and C-reactive protein (CRP)) and 3-T MRI of the clinically dominant hand. Read More

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-018-1789-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332674PMC
January 2019
12 Reads
3.753 Impact Factor

Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model.

Stem Cell Res Ther 2019 Jan 11;10(1):25. Epub 2019 Jan 11.

Institute of Science and Technology in Medicine, Guy Hilton Research Centre, Keele University, Thornburrow Drive, Stoke-on-Trent, ST4 7QB, UK.

Background: Osteochondral injuries represent a significant clinical problem requiring novel cell-based therapies to restore function of the damaged joint with the use of mesenchymal stromal cells (MSCs) leading research efforts. Pre-clinical studies are fundamental in translating such therapies; however, technologies to minimally invasively assess in vivo cell fate are currently limited. We investigate the potential of a MRI- (magnetic resonance imaging) and superparamagnetic iron oxide nanoparticle (SPION)-based technique to monitor cellular bio-distribution in an ovine osteochondral model of acute and chronic injuries. Read More

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https://stemcellres.biomedcentral.com/articles/10.1186/s1328
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http://dx.doi.org/10.1186/s13287-018-1123-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330448PMC
January 2019
11 Reads

Progression of Structural Damage in the Sacroiliac Joints in Patients With Early Axial Spondyloarthritis During Long-Term Anti-Tumor Necrosis Factor Treatment: Six-Year Results of Continuous Treatment With Etanercept.

Arthritis Rheumatol 2019 Jan 9. Epub 2019 Jan 9.

Charité Universitätsmedizin Berlin, and German Rheumatism Research Centre, Berlin, Germany.

Objective: To evaluate radiographic progression in the sacroiliac (SI) joints and to identify its predictors during long-term treatment (up to 6 years) with the tumor necrosis factor (TNF) inhibitor etanercept in patients with early axial spondyloarthritis (SpA).

Methods: Patients with early axial SpA who were treated with etanercept for up to 6 years in the Etanercept versus Sulfasalazine in Early Axial Spondyloarthritis (ESTHER) trial were selected based on the availability of radiographs of the SI joints. Two readers who were blinded with regard to clinical data scored the radiographs according to the modified New York criteria (range 0-4 per SI joint). Read More

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http://dx.doi.org/10.1002/art.40786DOI Listing
January 2019
2 Reads

Wash, Rinse, Repeat: Which Patients Undergo Serial Joint Irrigation in Pediatric Septic Hip Arthritis?

J Pediatr Orthop 2019 Jan 7. Epub 2019 Jan 7.

Boston Children's Hospital, Harvard University, Boston, MA.

Background: The purpose of this study is to identify risk factors associated with repeat surgical irrigation in pediatric septic hip arthritis.

Methods: A single center retrospective case-control study was performed. Patients who underwent ≥2 washouts (cases) were compared with those who had only 1 washout (controls). Read More

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http://Insights.ovid.com/crossref?an=01241398-900000000-9859
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http://dx.doi.org/10.1097/BPO.0000000000001323DOI Listing
January 2019
4 Reads

Abatacept in combination with methotrexate in Japanese biologic-naive patients with active rheumatoid arthritis: a randomised placebo-controlled phase IV study.

RMD Open 2018 4;4(2):e000813. Epub 2018 Dec 4.

Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

Objectives: To evaluate efficacy and safety of abatacept+methotrexate (MTX) in biologic-naive, anticitrullinated protein antibody (ACPA)-positive Japanese patients with active rheumatoid arthritis (RA) and early erosion versus placebo+MTX.

Methods: In this phase IV, multicentre, double-blind study (NCT01758198), patients were randomised (1:1) to receive intravenous abatacept (~10 mg/kg) or placebo, plus MTX (≥6 mg/week). Primary efficacy objectives were to compare American College of Rheumatology 20 (ACR20) response rates at week 16 and mean change from baseline in van der Heijde-modified total Sharp score (vdH-mTSS) at week 24 between abatacept+MTX and placebo+MTX groups. Read More

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http://rmdopen.bmj.com/lookup/doi/10.1136/rmdopen-2018-00081
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http://dx.doi.org/10.1136/rmdopen-2018-000813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307574PMC
December 2018
21 Reads

Paraneoplastic Encephalopathy in a Patient With Metastatic Lung Cancer: A Case Study.

Authors:
Scott M Rowley

J Adv Pract Oncol 2018 Mar 1;9(2):216-221. Epub 2018 Mar 1.

The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

RS, a 36-year-old female, presented to the emergency department (ED) of a large academic medical center upon the advice of her primary care provider because of 3 weeks of progressive mental status changes, weakness, and decreased oral intake. According to her husband, RS was diagnosed with stage IIIA large cell lung cancer 8 months earlier and was treated with concurrent chemotherapy (carboplatin, pemetrexed, and bevacizumab) and radiation therapy that was completed 4 months prior to admission. No other specific information about her treatment or outside health records was available. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303004PMC
March 2018
33 Reads

Quantitative tests reveal that microtubules tune the healthy heart but underlie arrhythmias in pathology.

J Physiol 2018 Dec 24. Epub 2018 Dec 24.

Centre for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, USA.

Key Points: Our group previously discovered and characterized the microtubule mechanotransduction pathway linking diastolic stretch to NADPH oxidase 2-derived reactive oxygen species signals that regulate calcium sparks and calcium influx pathways. Here we used focused experimental tests to constrain and expand our existing computational models of calcium signalling in heart. Mechanistic and quantitative modelling revealed new insights in disease including: changes in microtubule network density and properties, elevated NOX2 expression, altered calcium release dynamics, how NADPH oxidase 2 is activated by and responds to stretch, and finally the degree to which normalizing mechano-activated reactive oxygen species signals can prevent calcium-dependent arrhythmias. Read More

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http://dx.doi.org/10.1113/JP277083DOI Listing
December 2018
6 Reads

Acute severe monarthritis: a rare manifestation of scrub typhus.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Paediatrics, Kasturba Medical College, Manipal, Karnataka, India.

Scrub typhus caused by is an important cause for fever of unknown origin in endemic areas including India. The vasculitis associated with the disease leads to a variety of clinical manifestations. However, the joint involvement is quite rare and not reported in children. Read More

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http://dx.doi.org/10.1136/bcr-2018-227002DOI Listing
December 2018
6 Reads

Circulating Semaphorin 4D as a Marker for Predicting Radiographic Progression in Patients with Rheumatoid Arthritis.

Dis Markers 2018 14;2018:2318386. Epub 2018 Nov 14.

Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Semaphorin 3A (Sema3A) and semaphorin 4D (Sema4D) are molecules which regulate immune responses as well as bone remodeling process. The aim of this study was to evaluate the serum levels of Sema3A and Sema4D and to investigate their clinical significance in rheumatoid arthritis (RA). The serum levels of Sema3A and Sema4D were measured in 130 patients with RA and 65 sex- and age-matched healthy individuals. Read More

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http://dx.doi.org/10.1155/2018/2318386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261241PMC

Septic Arthritis of the Hip-Risk Factors Associated With Secondary Surgery.

J Am Acad Orthop Surg 2018 Dec 4. Epub 2018 Dec 4.

From the Department of Orthopaedics (Dr. R. F. Murphy, Dr. Plumblee, Dr. Barfield, and Dr. Dow), Medical University of South Carolina, Charleston SC, Children's Orthopaedics of Atlanta, Atlanta, GA (Dr. J. S. Murphy, Mr. Fuerstenau), the Department of Orthopaedics and Biomedical Engineering, University of Tennessee-Campbell Clinic, Memphis, TN (Dr. Spence and Dr. Kelly), and Shriner's Hospital for Children, Springfield, MA (Dr. Mooney).

Introduction: Septic arthritis of the hip (SAH) is a common condition encountered by pediatric orthopaedic surgeons and is treated with arthrotomy and irrigation. Depending on the response to initial treatment, some patients require surgical treatment beyond the index procedure. The purpose of this study was to investigate risk factors for repeat surgical intervention after initial arthrotomy for presumed SAH. Read More

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http://Insights.ovid.com/crossref?an=00124635-900000000-9945
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http://dx.doi.org/10.5435/JAAOS-D-18-00058DOI Listing
December 2018
28 Reads

DUSP6 Inhibitor (E/Z)-BCI Hydrochloride Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophage Cells via Activating the Nrf2 Signaling Axis and Inhibiting the NF-κB Pathway.

Inflammation 2019 Apr;42(2):672-681

School of Stomatology, Dalian Medical University, Dalian, 116044, People's Republic of China.

Macrophages play a fundamental role in human chronic diseases such as rheumatoid arthritis, atherosclerosis, and cancer. In the present study, we demonstrated that dual-specificity phosphatase 6 (DUSP6) was upregulated by lipopolysaccharide (LPS) treatment of macrophages. (E/Z)-BCI hydrochloride (BCI) functions as a small molecule inhibitor of DUSP6, and BCI treatment inhibited DUSP6 expression in LPS-activated macrophages. Read More

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http://dx.doi.org/10.1007/s10753-018-0924-2DOI Listing
April 2019
4 Reads

Regulatory role of capsaicin-sensitive peptidergic sensory nerves in the proteoglycan-induced autoimmune arthritis model of the mouse.

J Neuroinflammation 2018 Dec 3;15(1):335. Epub 2018 Dec 3.

János Szentágothai Research Centre, Molecular Pharmacology Research Team and Centre for Neuroscience, University of Pécs, Pécs, Hungary.

Objective: The regulatory role of capsaicin-sensitive peptidergic sensory nerves has been shown in acute inflammation, but little is known about their involvement in T/B-cell driven autoimmune arthritis. This study integratively characterized the function of these nerve endings in the proteoglycan-induced chronic arthritis (PGIA), a translational model of rheumatoid arthritis.

Methods: Peptidergic afferents were defunctionalized by resiniferatoxin (RTX) pretreatment in BALB/c mice, PGIA was induced by repeated antigen challenges. Read More

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https://jneuroinflammation.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12974-018-1364-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276168PMC
December 2018
14 Reads

Classifications and imaging of juvenile spondyloarthritis.

J Ultrason 2018 ;18(74):224-233

University of Nis, Faculty of Medicine, Department of Pediatric Rheumatology and Immunology, Serbia.

Juvenile spondyloarthritis may be present in at least 3 subtypes of juvenile idiopathic arthritis according to the classification of the International League of Associations for Rheumatology. By contrast with spondyloarthritis in adults, juvenile spondyloarthritis starts with inflammation of peripheral joints and entheses in the majority of children, whereas sacroiliitis and spondylitis may develop many years after the disease onset. Peripheral joint involvement makes it difficult to differentiate juvenile spondyloarthritis from other juvenile idiopathic arthritis subtypes. Read More

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http://jultrason.pl/index.php/issues/volume-18-no-74/classif
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http://dx.doi.org/10.15557/JoU.2018.0033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442218PMC
January 2018
24 Reads

Performance of routine assessment of patient index data 3 (RAPID3) in monitoring disease activity of Chinese rheumatoid arthritis patients.

Int J Rheum Dis 2018 Nov 6;21(11):1940-1945. Epub 2018 Nov 6.

Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing, China.

Aim: To explore the performance of routine assessment of patient index data 3 (RAPID3) in reflecting disease activity in Chinese rheumatoid arthritis (RA) patients.

Method: The clinical data of 189 consecutive RA patients, including RAPID3 questionnaire, Disease Activity Score based on 28-joint count (DAS28), clinical disease activity index (CDAI) and simplified disease activity index (SDAI), and ultrasonography of hand and wrist joints were collected. The consistency between RAPID3 and DAS28, CDAI, SDAI in RA patients with different disease activities was performed by Spearman's correlations, kappa and/or weighted kappa coefficients. Read More

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http://doi.wiley.com/10.1111/1756-185X.13405
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http://dx.doi.org/10.1111/1756-185X.13405DOI Listing
November 2018
11 Reads

Paediatric musculoskeletal infections with Panton-Valentine leucocidin.

Swiss Med Wkly 2018 09 23;148:w14669. Epub 2018 Sep 23.

Paediatric Trauma and Orthopaedic Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.

Aims Of The Study: Paediatric musculoskeletal infections by Panton-Valentine leucocidin (PVL)-producing Staphylococcus aureus constitute a rare, but highly critical event. They are characterised by a rapid course of marked inflammation, worsening under conservative therapy and a high rate of recurrence. This study aimed to illustrate the importance of paediatric PVL-producing S. Read More

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http://dx.doi.org/10.4414/smw.2018.14669DOI Listing
September 2018
2 Reads

[Differential diagnosis of axial spondyloarthritis-axSpA mimics].

Z Rheumatol 2019 Feb;78(1):31-42

Rheumazentrum Ruhrgebiet, Claudiusstr 45, 44649, Herne, Deutschland.

The classification of axial spondyloarthritis (axSpA) comprises the classical ankylosing spondylitis (AS), which is characterized by already existing structural changes in the sacroiliac joints, and the so-called non-radiographic axSpA (nr-axSpA), in which by definition such changes are not present. This distinction is based on the ASAS classification criteria for axSpA, which are however not suitable for a diagnosis. According to the current classification, spondyloarthritis (SpA) includes axSpA, which can be associated with psoriasis and/or chronic inflammatory bowel diseases (CED), such as Crohn's disease and ulcerative colitis, and peripheral SpA, which is further divided into SpA associated with psoriasis, partially synonymous with psoriatic arthritis (PsA), reactive SpA, partially synonymous with reactive arthritis (ReA) and SpA associated with CED, partially synonymous with arthritis associated with CED (e. Read More

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http://link.springer.com/10.1007/s00393-018-0557-8
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http://dx.doi.org/10.1007/s00393-018-0557-8DOI Listing
February 2019
6 Reads

exploits HLA-B27 and host unfolded protein responses to promote intracellular replication.

Ann Rheum Dis 2019 Jan 24;78(1):74-82. Epub 2018 Oct 24.

School of Medicine and Biological Sciences Research Complex, University of St Andrews, London, UK.

Objective: infections can lead to Reactive Arthritis (ReA), which can exhibit an association with human leucocyte antigen (HLA)-B*27:05, a molecule prone to misfolding and initiation of the unfolded protein response (UPR). This study examined how HLA-B*27:05 expression and the UPR affect the life-cycle within epithelial cells.

Methods: Isogenic epithelial cell lines expressing two copies of either HLA-B*27:05 and a control HLA-B*35:01 heavy chain (HC) were generated to determine the effect on the infection life-cycle. Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21353
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http://dx.doi.org/10.1136/annrheumdis-2018-213532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317449PMC
January 2019
10 Reads

Osteoid osteoma: multimodality imaging with focus on hybrid imaging.

Eur J Nucl Med Mol Imaging 2019 Apr 19;46(4):1019-1036. Epub 2018 Oct 19.

Department of Radiology and Nuclear Medicine, Cantonal Hospital Lucerne, Lucerne, Switzerland.

Osteoid osteoma is a painful, benign, osteoblastic lesion that occurs in younger patients and affects the extremities or the axial skeleton. While plain film findings may suggest the diagnosis, in complex anatomical regions such as the spine, pelvis, wrist and foot advanced imaging modalities are often required. A typical nidus surrounded by sclerosis or cortical thickening characterizes osteoid osteoma on plain radiography and CT. Read More

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http://link.springer.com/10.1007/s00259-018-4181-2
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http://dx.doi.org/10.1007/s00259-018-4181-2DOI Listing
April 2019
16 Reads

Incidental F-FDG Uptake of the Pubic Ramus and Abdominal Muscles due to Athletic Pubalgia During Acute Prostatitis

Mol Imaging Radionucl Ther 2018 Oct;27(3):133-135

University Hospital of Geneva, Clinic of Nuclear Medicine, Geneva, Switzerland

A 23-year-old African native male patient presented with fever, lumbalgia and dysuria after returning from a trip to Togo. His physical examination revealed pain over the pubic symphysis and rectal tenderness on digital exam. The C-reactive protein (CRP) level was elevated along with positive blood and urinary cultures for methicillin-resistant . Read More

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http://cms.galenos.com.tr/Uploads/Article_19783/MIRT-27-133-
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http://dx.doi.org/10.4274/mirt.19484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191733PMC
October 2018
4 Reads

A single determination of C-reactive protein does not suffice to declare a patient with a diagnosis of axial spondyloarthritis 'CRP-negative'.

Arthritis Res Ther 2018 09 14;20(1):209. Epub 2018 Sep 14.

UCB Pharma, Brussels, Belgium.

Background: To be eligible to receive treatment with an anti-tumour necrosis factor (TNF), non-radiographic axial spondyloarthritis (nr-axSpA) patients require either elevated levels of C-reactive protein (CRP) (CRP > upper limit of normal (ULN)) or magnetic resonance imaging assessment showing inflammation of the sacroiliac joints, in addition to meeting criteria for high disease activity. Many axSpA patients are classified as 'CRP-negative', or CRP normal, despite having levels close to the ULN, and are therefore formally ineligible for treatment. The aim of this study was to investigate the likelihood of a CRP test indicating elevated levels in axSpA patients that have previously tested CRP normal. Read More

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http://dx.doi.org/10.1186/s13075-018-1707-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137888PMC
September 2018
1 Read

Advances in the treatment of uveitis in patients with spondyloarthritis - is it the time for biologic therapy?

Rom J Ophthalmol 2018 Apr-Jun;62(2):114-122

Department of Ophthalmology, University Emergency Hospital, Bucharest, Romania.

Spondyloarthritis (SpA) is a heterogeneous group of diseases that includes ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis (ReA), inflammatory bowel disease-associated spondyloarthritis (IBD-SpA), and undifferentiated spondyloarthritis (unSpA). This group of diseases shares several clinical, imaging, and genetic features; the integration of these diseases in the group of SpA is needed for an early diagnosis and a prompt treatment. Uveitis is the most common extra-articular manifestation of SpA. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117524PMC
February 2019
13 Reads

Clinical Responses and Synovial Vascularity in Obese Rheumatoid Arthritis Patients Treated with Adalimumab and Methotrexate.

J Rheumatol 2018 Dec 1;45(12):1628-1635. Epub 2018 Sep 1.

From the Division of Rheumatology and Clinical Immunology, University of Florida College of Medicine, Jacksonville, Florida; Department of Rheumatology, North Valley Hospital, Whitefish, Montana; Global Medical Affairs, AbbVie Inc., North Chicago, Illinois; Data and Statistical Sciences, AbbVie Inc., North Chicago, Illinois; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California, USA; Pharmaceutical Development, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany.

Objective: Obese patients with rheumatoid arthritis (RA) report more joint swelling and tenderness and often have poorer responses to therapy than nonobese patients. The aim of this posthoc analysis of the MUSICA trial was to compare imaging and clinical disease activity measures in obese and nonobese patients with RA.

Methods: MUSICA evaluated methotrexate (MTX) 20 mg/week versus 7. Read More

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http://dx.doi.org/10.3899/jrheum.171232DOI Listing
December 2018
15 Reads

Heart Rate-corrected QT Interval Duration in Rheumatoid Arthritis and Its Reduction with Treatment with the Interleukin 6 Inhibitor Tocilizumab.

J Rheumatol 2018 Dec 1;45(12):1620-1627. Epub 2018 Sep 1.

From the Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo; Department of Advanced Biomedical Imaging Informatics, St. Marianna University School of Medicine, Kawasaki, Japan; Division of Rheumatology, Columbia University, College of Physicians and Surgeons, New York, New York, USA.

Objective: Individuals with rheumatoid arthritis (RA) are at a heightened risk of sudden cardiac death, an outcome increased in those with prolongation of the corrected electrocardiographic QT interval (QTc). We compared QTc between patients with RA and demographically matched controls and studied the change in QTc after treatment with the interleukin 6 inhibitor tocilizumab (TCZ).

Methods: Standard 12-lead electrocardiograms were obtained and QTc was measured in patients with RA at baseline and after 24 weeks of TCZ treatment, then compared with non-RA controls who were frequency-matched on age and sex. Read More

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http://dx.doi.org/10.3899/jrheum.180065DOI Listing
December 2018
25 Reads

Does patients' opinion of remission in rheumatoid arthritis overlap ultrasound "true" remission? - a pilot study.

Med Ultrason 2018 Aug;20(3):328-334

Carol Davila University of Medicine and Pharmacy.

Aim: Patients describe rheumatoid arthritis (RA) remission as the absence of any symptoms or return to normality. Residual ultrasound (US) synovitis was frequently described in remission cohorts in previous studies. US tenosynovitis evaluation and scoring seems to better follow clinical remission scores compared with synovitis in RA. Read More

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http://dx.doi.org/10.11152/mu-1384DOI Listing
August 2018
18 Reads

A prospective study of screening for musculoskeletal pathology in the child with a limp or pseudoparalysis using erythrocyte sedimentation rate, C-reactive protein and MRI.

J Child Orthop 2018 Aug;12(4):398-405

Department of Orthopaedic Surgery, Peterborough City Hospital, Bretton Gate, Peterborough, UK.

Purpose: To determine if the detection of musculoskeletal pathology in children with a limp or acute limb disuse can be optimized by screening with blood tests for raised inflammatory markers, followed by MRI.

Methods: This was a prospective observational study. Entry criteria were children (0 to 16 years of age) presenting to our emergency department with a non-traumatic limp or pseudoparalysis of a limb, and no abnormality on plain radiographs. Read More

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http://dx.doi.org/10.1302/1863-2548.12.180004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090194PMC
August 2018
3 Reads

[Necrotizing fasciitis caused by a Garengeot's hernia. Case report].

Rev Med Chil 2018 May;146(5):660-664

Departamento de Cirugía Digestiva, Hospital Clínico, Pontificia Universidad Católica de Chile, Santiago, Chile.

Garengeot's hernia corresponds to the presence of the appendix within a femoral hernia, associated or not with acute appendicitis. The diagnosis of this uncommon situation is usually done during surgery. Furthermore, the clinical presentation as necrotizing fasciitis is a rare condition. Read More

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http://dx.doi.org/10.4067/s0034-98872018000500660DOI Listing
May 2018
24 Reads

Multidrug-resistance Acinetobacter baumannii pneumonia in a rheumatoid arthritis patient receiving tumor necrosis factor inhibitor: A case report.

Medicine (Baltimore) 2018 Aug;97(33):e11730

Division of Rheumatology/Immunology and Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei.

Introduction: Multidrug-resistant Acinetobacter baumannii (MDRAB) pneumonia with severe sepsis in a patient with rheumatoid arthritis (RA), who is predisposed after treatment with tumor necrosis factor inhibitor (TNFI), is a rare severe infection and can be successfully treated with prompt antibiotics.

Case Presentation: A 75-year-old woman was diagnosed with RA >30 years previously. After inadequate treatment responses to conventional disease-modifying antirheumatic drugs (DMARDs), she developed progressive RA, including swollen joints in both hands, and had a high disease activity score of 4. Read More

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http://dx.doi.org/10.1097/MD.0000000000011730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113047PMC
August 2018
12 Reads

Methotrexate prodrugs sensitive to reactive oxygen species for the improved treatment of rheumatoid arthritis.

Eur J Med Chem 2018 Aug 20;156:738-746. Epub 2018 Jul 20.

Center for Nanomedicine & Theranostics, Department of Chemistry, Technical University of Denmark, Kemitorvet 207, DK, 2800, Kongens Lyngby, Denmark. Electronic address:

Methotrexate (MTX) is the standard of care in the treatment of rheumatoid arthritis (RA), a common autoimmune disease that is characterized by chronic inflammation in the synovial membrane of joints. Unfortunately, MTX suffers from high discontinuation rates due to a large variability in efficacy and, in particular, adverse effects. As inflammation is associated with elevated levels of reactive oxygen species (ROS) like HO, we propose to improve treatment through site-selective delivery of MTX to inflammatory tissue by use of a HO sensitive MTX prodrug. Read More

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http://dx.doi.org/10.1016/j.ejmech.2018.07.045DOI Listing
August 2018
5 Reads

Assessment of subclinical atherosclerosis in psoriatic arthritis patients without clinically overt cardiovascular disease or traditional atherosclerosis risk factors.

Turk Kardiyol Dern Ars 2018 07;46(5):358-365

Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Objective: Cardiovascular disease (CVD) is more prevalent in almost all patients with chronic inflammatory musculoskeletal diseases than in their healthy counterparts. The aim of this study was to assess the presence of subclinical atherosclerosis in patients with psoriatic arthritis (PsA) in comparison with patients with rheumatoid arthritis (RA) and healthy controls.

Methods: A total of 30 patients with PsA, 30 patients with RA, and 30 healthy controls were enrolled in this parallel group study. Read More

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http://dx.doi.org/10.5543/tkda.2018.36169DOI Listing
July 2018
8 Reads

MRI findings for unilateral sternoclavicular arthritis: differentiation between infectious arthritis and spondyloarthritis.

Skeletal Radiol 2019 Feb 5;48(2):259-266. Epub 2018 Jul 5.

Department of Radiology, University of Ulsan College of Medicine, Ulsan University Hospital, 877 Bangeojinsunhwan-doro, Dong-gu, Ulsan, 44033, South Korea.

Objectives: To analyze and identify magnetic resonance imaging (MRI) and clinical findings for the differentiation between infectious arthritis and spondyloarthritis in patients with unilateral sternoclavicular arthritis.

Materials And Methods: We retrospectively collected and evaluated the magnetic resonance (MR) images of 21 patients diagnosed with unilateral sternoclavicular arthritis, including 12 with infection and nine with spondyloarthritis, between 2004 and 2017. Capsular distension, extracapsular fluid collection, periarticular muscle edema, the prevalence and distribution of bone marrow edema, and the prevalence and size of bone erosions were assessed on the MR images. Read More

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http://link.springer.com/10.1007/s00256-018-3023-4
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http://dx.doi.org/10.1007/s00256-018-3023-4DOI Listing
February 2019
27 Reads

Influence of Axial Involvement on Clinical Characteristics of Psoriatic Arthritis: Analysis from the Corrona Psoriatic Arthritis/Spondyloarthritis Registry.

J Rheumatol 2018 Oct 1;45(10):1389-1396. Epub 2018 Jul 1.

From the Swedish Medical Center and University of Washington, Seattle, Washington; Novartis Pharmaceuticals Corp., East Hanover, New Jersey; Corrona LLC, Waltham, Massachusetts; University of California San Diego, La Jolla, California; Allergy, Immunology and Rheumatology Division, University of Rochester Medical Center, Rochester; New York University School of Medicine, New York, New York, USA.

Objective: We analyzed the characteristics of patients with psoriatic arthritis (PsA) with and without axial involvement in the US-based Corrona Psoriatic Arthritis/Spondyloarthritis Registry.

Methods: All patients were included who had PsA and data on axial involvement, defined as physician-reported presence of spinal involvement at enrollment, and/or radiograph or magnetic resonance imaging showing sacroiliitis. Demographics, clinical measures, patient-reported outcomes, and treatment characteristics were assessed at enrollment. Read More

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http://dx.doi.org/10.3899/jrheum.171094DOI Listing
October 2018
20 Reads

Cerebral amyloid angiopathy-related inflammation with epilepsy mimicking a presentation of brain tumor: A case report and review of the literature.

Int J Surg Case Rep 2018 29;48:95-100. Epub 2018 May 29.

Department of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime 791-0295, Japan.

Introduction: Cerebral amyloid angiopathy-related inflammation (CAA-ri), a rare and treatable variant of cerebral amyloid angiopathy, lacks specific imaging and clinical features, and requires invasive brain biopsy to confirm the diagnosis. We report the case of a patient with nonconvulsive status epilepticus (NCSE) caused by CAA-ri in the right occipital lobe.

Presentation Of Case: A 78-year-old man with a history of hypertension and rheumatoid arthritis was admitted to our hospital following an episode of seizures. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041117PMC
May 2018
8 Reads

Salicin from Alangium chinense Ameliorates Rheumatoid Arthritis by Modulating the Nrf2-HO-1-ROS Pathways.

J Agric Food Chem 2018 Jun 11;66(24):6073-6082. Epub 2018 Jun 11.

School of Food Science and Engineering , Hefei University of Technology , Hefei 230009 , P. R. China.

Rheumatoid arthritis (RA) is a chronic inflammatory disorder linked to oxidative stress of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs). The effects and potential mechanism of salicin on inflammation and oxidative stress of RA-FLSs were examined by MTT, ELISA, and Western blot methods. Salicin significantly reduced cell viability (82. Read More

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http://dx.doi.org/10.1021/acs.jafc.8b02241DOI Listing
June 2018
7 Reads
2.912 Impact Factor

Association between IL-6 production in synovial explants from rheumatoid arthritis patients and clinical and imaging response to biologic treatment: A pilot study.

PLoS One 2018 22;13(5):e0197001. Epub 2018 May 22.

The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark.

Introduction: The need for biomarkers which can predict disease course and treatment response in rheumatoid arthritis (RA) is evident. We explored whether clinical and imaging responses to biologic disease modifying anti-rheumatic drug treatment (bDMARD) were associated with the individual's mediator production in explants obtained at baseline.

Methods: RA Patients were evaluated by disease activity score 28 joint C-reactive protein (DAS 28-)), colour Doppler ultrasound (CDUS) and 3 Tesla RA magnetic resonance imaging scores (RAMRIS). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197001PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963776PMC
July 2018
7 Reads