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    The Influence of Reactive Oxygen Species and Glucocorticoids on Dry Skin in a Mouse Model of Arthritis.
    Skin Pharmacol Physiol 2018 Apr 26;31(4):188-197. Epub 2018 Apr 26.
    Laboratory of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Japan.
    Background: Dry skin induced by rheumatoid arthritis (RA) causes itching, which negatively influences a patient's quality of life. We previously reported that mast cells are related to dry skin in arthritic mice. However, the mechanism of mast cell activation is unclear. Read More
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    TLR9 deficiency breaks tolerance to RNA-associated antigens and upregulates TLR7 protein in Sle1 mice.
    Arthritis Rheumatol 2018 Apr 24. Epub 2018 Apr 24.
    Singapore Immunology Network, A*STARSingapore.
    Objective: Toll-like receptors (TLRs) 7 and 9 are important innate signaling molecules with opposing roles in the development and progression of Systemic Lupus Erythematosus (SLE). While multiple studies support a dependency on TLR7 for disease development, genetic ablation of TLR9 results in severe disease with glomerulonephritis (GN) by a largely unknown mechanism. The present study was designed to examine the suppressive role of TLR9 in the development of severe lupus. Read More
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    Gonococcal Tenosynovitis Diagnosed with the Aid of Emergency Department Bedside Ultrasound.
    J Emerg Med 2018 Apr 20. Epub 2018 Apr 20.
    Department of Emergency Medicine, Northwell Health Long Island Jewish Medical Center, New Hyde Park, New York.
    Background: Gonorrhea is the second most common sexually transmitted infection. Disseminated gonococcal infection (DGI) consists of gonococcal infection plus one or more of the triad of arthritis, tenosynovitis, and dermatitis. Diagnosis in the emergency department (ED) must be suspected clinically, as confirmatory tests are often not available. Read More
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    Role of Interleukin 37 as a Novel Proangiogenic Factor in Juvenile Idiopathic Arthritis.
    J Clin Rheumatol 2018 Apr 16. Epub 2018 Apr 16.
    Objective: The aim of this study was to investigate interleukin 37 (IL-37) levels in the serum and synovial fluid of patients with juvenile idiopathic arthritis (JIA), its expression in peripheral blood mononuclear cells, and correlation with disease activity and angiogenesis.

    Methods: Seventy JIA patients and 50 control subjects were examined. The Juvenile Arthritis Disease Activity Score in 27 joints (JADAS-27) was calculated. Read More
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    Baricitinib in Patients with Rheumatoid Arthritis and an Inadequate Response to Conventional Disease-Modifying Antirheumatic Drugs in United States and Rest of World: A Subset Analysis.
    Rheumatol Ther 2018 Apr 21. Epub 2018 Apr 21.
    Eli Lilly and Company, Indianapolis, IN, USA.
    Introduction: This article evaluates the efficacy and safety of baricitinib 4 mg versus placebo in United States including Puerto Rico (US) and rest of the world (ROW) subpopulations using data pooled from RA-BEAM and RA-BUILD, which enrolled patients with moderate-to-severe adult-onset rheumatoid arthritis (RA).

    Methods: In RA-BEAM, patients with an inadequate response (IR) to methotrexate, at least one X-ray erosion, and high sensitivity C-reactive protein (hsCRP) ≥ 6 mg/L were randomized to placebo or orally administered baricitinib 4 mg daily or subcutaneously administered adalimumab 40 mg every other week. In RA-BUILD, patients with an IR to at least one conventional synthetic disease-modifying antirheumatic drug (csDMARD) and with hsCRP ≥ 3. Read More
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    Baseline patient reported outcomes are more consistent predictors of long-term functional disability than laboratory, imaging or joint count data in patients with early inflammatory arthritis: A systematic review.
    Semin Arthritis Rheum 2018 Mar 15. Epub 2018 Mar 15.
    Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK; NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, UK. Electronic address:
    Objective: To assess baseline predictors of long-term functional disability in patients with inflammatory arthritis (IA).

    Methods: We conducted a systematic review of the literature from 1990 to 2017 using MEDLINE and EMBASE. Studies were included if (i) they were prospective observational studies, (ii) all patients had IA with symptom duration ≤2 years at baseline, (iii) follow-up was at least 5 years, and (iv) baseline predictors of HAQ score at long-term follow-up (i. Read More
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    An unexpected cause of sacroiliitis in a patient with gout and chronic psoriasis with inflammatory arthritis: a case report.
    BMC Musculoskelet Disord 2018 Apr 20;19(1):126. Epub 2018 Apr 20.
    Rheumatology Department, Cork University Hospital, Cork, Ireland.
    Background: Inflammatory back pain is a condition characterized by inflammation of the sacroiliac joints and lower spine. It is frequently seen in patients with spondyloarthropathies like ankylosing spondylitis, psoriatic arthritis, enteropathic arthritis and reactive arthritis. Inflammatory back pain can be caused by many other conditions like infection and crystal deposition such as gout. Read More
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    Impact of changes in inflammation on estimated 10-year cardiovascular risk in rheumatoid arthritis.
    Arthritis Rheumatol 2018 Apr 20. Epub 2018 Apr 20.
    Division of Rheumatology, Allergy and Immunology, Brigham and Women's Hospital, Boston, MA.
    Background: Validated cardiovascular (CV) risk estimates were developed in populations with relatively stable inflammatory levels. In rheumatoid arthritis (RA), patients routinely experience significant changes in inflammation. We tested whether changes in inflammation impact estimated CV risk as measured using validated population-based risk calculators. Read More
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    Spondyloarthritis, Acute Anterior Uveitis, and Fungi: Updating the Catterall-King Hypothesis.
    Front Med (Lausanne) 2018 5;5:80. Epub 2018 Apr 5.
    Department of Ophthalmology, Oregon Health and Science University, Portland, OR, United States.
    Spondyloarthritis is a common type of arthritis which affects mostly adults. It consists of idiopathic chronic inflammation of the spine, joints, eyes, skin, gut, and prostate. Inflammation is often asymptomatic, especially in the gut and prostate. Read More
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    Imaging to Differentiate the Various Forms of Seronegative Arthritis.
    Semin Musculoskelet Radiol 2018 Apr 19;22(2):189-196. Epub 2018 Apr 19.
    Department of Radiology, National Institute of Geriatrics, Rheumatology and Rehabilitation and Imaging Diagnostic Department, Warsaw Medical University, Warsaw, Poland.
    Spondyloarthritis (SpA) is a group of diseases characterized by back pain, spinal inflammation, human leukocyte antigen-B27 positivity, and peripheral findings such as dactylitis, enthesitis, and uveitis. It includes ankylosing spondylitis, psoriatic arthritis, reactive arthritis, arthritis associated with inflammatory bowel disease, and undifferentiated SpA. The role of imaging in the diagnosis, management, and follow-up of patients with SpA has become dramatically more important with the introduction of new therapies such as tumor necrosis factor-α inhibitors. Read More
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    Rheumatoid Arthritis: Common Questions About Diagnosis and Management.
    Am Fam Physician 2018 Apr;97(7):455-462
    Westchester Medical Center, New York Medical College, Valhalla, NY, USA.
    Rheumatoid arthritis is the most commonly diagnosed systemic inflammatory arthritis, with a lifetime prevalence of up to 1% worldwide. Women, smokers, and those with a family history of the disease are most often affected. Rheumatoid arthritis should be considered if there is at least one joint with definite swelling that is not better explained by another disease. Read More
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    Poststreptococcal Illness: Recognition and Management.
    Am Fam Physician 2018 Apr;97(8):517-522
    University of Tennessee Family Medicine Residency Program, Jackson, TN, USA.
    Group A beta-hemolytic streptococcus can cause several postinfectious, nonsuppurative immune- mediated diseases including acute rheumatic fever, poststreptococcal reactive arthritis, pediatric autoimmune neuropsychiatric disorders, and poststreptococcal glomerulonephritis. Except for sporadic outbreaks, poststreptococcal autoimmune syndromes occur most commonly in sub-Saharan Africa, India, Australia, and New Zealand. Children younger than three years are rarely affected by group A streptococcus pharyngitis or rheumatic fever, and usually do not require testing. Read More
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    Myeloperoxidase as an Active Disease Biomarker: Recent Biochemical and Pathological Perspectives.
    Med Sci (Basel) 2018 Apr 18;6(2). Epub 2018 Apr 18.
    Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, AlQassim, P.O. Box 6699, Buraidah 51452, Saudi Arabia.
    Myeloperoxidase (MPO) belongs to the family of heme-containing peroxidases, produced mostly from polymorphonuclear neutrophils. The active enzyme (150 kDa) is the product of the gene located on long arm of chromosome 17. The primary gene product undergoes several modifications, such as the removal of introns and signal peptides, and leads to the formation of enzymatically inactive glycosylated apoproMPO which complexes with chaperons, producing inactive proMPO by the insertion of a heme moiety. Read More
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    Pathobiochemical Mechanisms Relating Iron Homeostasis with Parameters of Inflammatory Activity and Autoimmune Disorders in Rheumatoid Arthritis.
    Folia Med (Plovdiv) 2018 Mar;60(1):124-132
    Department of Analytical Chemistry and Computer Chemistry, Faculty of Chemistry, Paisii Hilendarski University of Plovdiv, Plovdiv, Bulgaria.
    Aim: To find the correlations between the parameters of iron homeostasis, inflammatory activity and autoimmune disorders in rheumatoid arthritis (RA).

    Materials And Methods: The present study included 114 patients with RA and 42 healthy controls. We determined the parameters of iron homeostasis: serum iron, total iron binding capacity (TIBC), ferritin and soluble transferrin receptor (sTfR), the parameters of inflammatory activity: C-reactive protein (CRP), interleukin-6 (IL-6) and prohepcidin, and the parameters of autoimmune disorders: rheumatoid factor (RF), anti-cyclic citrullinated peptide (antiCCP) antibodies and DAS 28. Read More
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    Treatment patterns among patients with rheumatic disease (rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA) and undifferentiated arthritis (UnA)) treated with subcutaneous TNF inhibitors.
    Clin Rheumatol 2018 Apr 18. Epub 2018 Apr 18.
    RPA Institute of Rheumatology and Orthopaedics, Camperdown, NSW, Australia.
    The aim was to describe the real-world treatment persistence of subcutaneous TNF inhibitors (TNFi) for patients with inflammatory rheumatic disease newly initiating treatment with biologic disease-modifying antirheumatic drugs (bDMARD). This was a retrospective cohort study that extracted data for new users of TNFi between 1 August 2010 and 31 August 2016 from the Australian Optimising Patient outcome in Australian RheumatoLogy (OPAL) registry. Patients were 1:1 propensity-score matched with golimumab based on their age, sex, year of index, C-reactive protein level, baseline treatment combination and disease. Read More
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    A rare cause of oligoarthritis with septic presentation.
    BMJ Case Rep 2018 Apr 17;2018. Epub 2018 Apr 17.
    General Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
    A 33-year-old man presented with new-onset, asymmetric, migratory oligoarthritis in the setting of several weeks of nausea and vomiting, diarrhoea, fevers and dysuria. He was initially treated in the inpatient setting with broad-spectrum antibiotics due to concern for an evolving sepsis presentation. Arthrocentesis of a large right knee effusion revealed inflammatory synovial fluid without findings suggestive of septic arthritis. Read More
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    Common Evaluations of Disease Activity in Rheumatoid Arthritis Reach Discordant Classifications across Different Populations.
    Front Med (Lausanne) 2018 8;5:40. Epub 2018 Mar 8.
    Faculdade de Medicina da Universidade de Coimbra, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal.
    Objectives: The classification of disease activity states in rheumatoid arthritis (RA) can be achieved through disease activity indices, such as the Disease Activity Score in 28 joints erythrocyte sedimentation rate (DAS28-ESR), the Simplified Disease Activity Index (SDAI), and the Clinical Disease Activity Index (CDAI). Subjective measurements, such as patient reported outcomes have been incorporated into several of these indices alongside more objective assessments, such as increases in the ESR and C-reactive protein. Moreover, while they use similar criteria, different indices weight these criteria to different extents. Read More
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    Management of Juvenile Idiopathic Arthritis in ABO-incompatible Kidney Transplantation: A Case Report.
    Transplant Proc 2018 Apr;50(3):869-872
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata Graduate School of Medical and Dental Sciences, Niigata, Japan.
    Biologic agents are a beneficial therapy for juvenile idiopathic arthritis (JIA). However, there is a lack of evidence with regard to management of these agents for JIA patients who undergo kidney transplantation (KTx). A 36-year-old woman with JIA who was treated with tocilizumab targeting interleukin-6 (IL-6) receptor underwent ABO-incompatible kidney transplantation (ABOi KTx). Read More
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    Reactive Periostitis from Inhalant Abuse.
    Arthritis Rheumatol 2018 Apr 16. Epub 2018 Apr 16.
    Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA, 52242.
    The patient, a 36-year-old woman, presented with a 6-week history of swollen hands and fingers and associated arthralgia. She had a history of polysubstance abuse. The arthralgia and swelling started one month after she began inhaling two cans of "Dust-Off" (1,1-difluoroethane) daily. Read More
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    Is the serum oxytocin level altered by treatment in rheumatoid arthritis patients complicated with depression?
    Eur J Rheumatol 2018 Mar 22;5(1):22-26. Epub 2018 Jan 22.
    Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan.
    Objective: The objective of this study was to investigate the factors associated with depression, including serum oxytocin (OXT) levels, disease activity, activities of daily living (ADL), and quality of life (QOL), and their effects on rheumatoid arthritis (RA).

    Methods: This study included 42 RA patients who received treatment with a biological agent. We measured the following variables before and after 6 months of treatment: baseline characteristics, including age, sex, disease duration, smoking, and body mass index (BMI); prednisolone and methotrexate dose; serum level of matrix metalloproteinase-3 (MMP-3); erythrocyte sedimentation rate (ESR); and C-reactive protein (CRP) level. Read More
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    Conversion to seronegative status after abatacept treatment in patients with early and poor prognostic rheumatoid arthritis is associated with better radiographic outcomes and sustained remission: post hoc analysis of the AGREE study.
    RMD Open 2018 30;4(1):e000564. Epub 2018 Mar 30.
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
    Objective: To evaluate the effects of the T-cell costimulation blocker abatacept on anti-citrullinated protein antibodies (ACPA) and rheumatoid factor (RF) in early rheumatoid arthritis (RA), and associations between changes in serological status and clinical response.

    Methods: Post hoc analysis of the phase III AGREE study in methotrexate (MTX)-naïve patients with early RA and poor prognostic factors. Patients were randomised to abatacept (~10 mg/kg intravenously according to weight range) or placebo, plus MTX over 12 months followed by open-label abatacept plus MTX for 12 months. Read More
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    Absence of Fibrosis and Inflammation by Cardiac Magnetic Resonance Imaging in Rheumatoid Arthritis Patients with Low to Moderate Disease Activity.
    J Rheumatol 2018 Apr 15. Epub 2018 Apr 15.
    From the Vanderbilt University Medical Center; Veterans Health Administration Tennessee Valley Healthcare System, Nashville, Tennessee; Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Maryland, USA. This study was funded by the Arthritis Foundation Innovative Research Grant (Stein), Veterans Administration CDA IK2CX001269 (Ormseth), US National Institutes of Health (NIH) Grants: US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) K23 AR068443 (Ormseth), NIAMS P60 056116 (Stein), US National Heart, Lung and Blood Institute K23 HL123938 (Soslow), and Clinical and Translational Science Awards UL1TR000445 from the National Center for Advancing Translational Sciences (NCATS) and the NIH Intramural Research Program. The contents of this article are solely the responsibility of the authors and do not necessarily represent official views of the NCATS or the NIH. W. Bradham, MD, PhD, Vanderbilt University Medical Center; M.J. Ormseth, MD, MSCI, Vanderbilt University Medical Center, and Veterans Health Administration Tennessee Valley Healthcare System; C. Elumogo, BS, Radiology and Imaging Sciences, NIH; S. Palanisamy, BS, Radiology and Imaging Sciences, NIH; C.Y. Liu, PhD, Radiology and Imaging Sciences, NIH; M.A. Lawson, MD, Vanderbilt University Medical Center; J.H. Soslow, MD, MSCI, Vanderbilt University Medical Center; N. Kawel-Boehm, MD, Radiology and Imaging Sciences, NIH; D.A. Bluemke, MD, PhD, Radiology and Imaging Sciences, NIH; C.M. Stein, MBChB, Vanderbilt University Medical Center. W. Bradham and M.J. Ormseth contributed equally to this work. Address correspondence to Dr. M.J. Ormseth, 1161 21st Ave. South, T-3113 MCN, Nashville, Tennessee 37232-2681, USA. E-mail: Accepted for publication January 3, 2018.
    Objective: The prevalence of heart failure is increased 2-fold in patients with rheumatoid arthritis (RA); this is not explained by ischemic heart disease or other risk factors for heart failure. We hypothesized that in patients with RA without known heart disease, cardiac magnetic resonance imaging (cMRI) would detect altered cardiac structure, function, and fibrosis.

    Methods: We performed 1. Read More
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    Cardiovascular risk factors predicting cardiac events are different in patients with rheumatoid arthritis, psoriatic arthritis, and psoriasis.
    Semin Arthritis Rheum 2018 Mar 17. Epub 2018 Mar 17.
    Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff University, Cardiff, United Kingdom.
    Objectives: Increased cardiovascular risk in rheumatoid arthritis (RA) is well established. Examining traditional cardiovascular risk factors alone underestimates cardiovascular risk in RA. Systematic inflammation, measured by erythrocyte sedimentation rate or C-reactive protein is also a major risk factor. Read More
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    Serum calprotectin may reflect inflammatory activity in patients with active rheumatoid arthritis despite normal to low C-reactive protein.
    Clin Rheumatol 2018 Apr 14. Epub 2018 Apr 14.
    Institute of Rheumatology, Prague, Czech Republic, Na Slupi 4, 120 50, Prague 2, Czech Republic.
    Approximately half of patients with rheumatoid arthritis (RA) have normal C-reactive protein (CRP) levels. Calprotectin is a promising and likely more specific biomarker of disease activity than conventionally used acute phase reactants. We aimed to analyse the levels of serum calprotectin in RA patients with clinically active disease and with normal/low CRP. Read More
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    Influence of Blue Mussel () Intake on Disease Activity in Female Patients with Rheumatoid Arthritis: The MIRA Randomized Cross-Over Dietary Intervention.
    Nutrients 2018 Apr 13;10(4). Epub 2018 Apr 13.
    Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
    Rheumatoid Arthritis (RA) is a chronic inflammatory disease. This study evaluates the effect of blue mussel intake on disease activity and quality of life in women with RA. Thirty-nine women with established RA and a disease activity score 28 (DAS28) >3. Read More
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    Microwave Radiometry-Derived Thermal Changes of Small Joints as Additional Potential Biomarker in Rheumatoid Arthritis: A Prospective Pilot Study.
    J Clin Rheumatol 2018 Apr 13. Epub 2018 Apr 13.
    Objective: A prospective pilot study was performed using microwave radiometry (MR), a noninvasive method detecting in-depth tissue temperature, to evaluate whether temperature-of-small-joint-derived scores correlate to parameters commonly used to assess disease activity in rheumatoid arthritis (RA).

    Methods: Ten patients with active, untreated RA underwent clinical and laboratory assessments and joint ultrasound and MR of hand and foot small joints at baseline and at 15, 30, and 90 days after treatment onset. Mixed-model analysis for repeated measures was used to compare patient characteristics in sequential visits. Read More
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    [A Case of Resected Reactive Lymphoid Hyperplasia of Liver Suspected of Hepatocellular Carcinoma].
    Gan To Kagaku Ryoho 2018 Apr;45(4):728-730
    Dept. of Surgery, Nara City Hospital.
    A 64-year-old woman who had chronic type C viral hepatitis was referred with a liver tumor detected by magnetic resonance imaging(MRI). She had a history of rheumatoid arthritis which was treated by methotrexate. Ethoxybenzyl-MRI(EOBMRI) showed a low signal in the T1-weighted imaging, a high signal in the T2-weighted imaging and a low signal in the hepatobiliary phase. Read More
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    Metabolic syndrome and the decreased levels of uric acid by leflunomide favor redox imbalance in patients with rheumatoid arthritis.
    Clin Exp Med 2018 Apr 11. Epub 2018 Apr 11.
    Department of Internal Medicine, University of Londrina, Londrina, Paraná, Brazil.
    Oxidative stress plays a role in the pathophysiology of rheumatoid arthritis (RA). The aim of the present study was to verify the influence of metabolic syndrome (MetS) and disease-modifying antirheumatic drugs on nitrosative and oxidative biomarkers in patients with RA. A total of 177 patients with RA and 150 healthy volunteers participated in this study, which measured lipid hydroperoxides, advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), carbonyl protein, total radical-trapping antioxidant parameter (TRAP), uric acid (UA), and C-reactive protein (CRP). Read More
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    Failure of remission induction by glucocorticoids alone or in combination with immunosuppressive agents in IgG4-related disease: a prospective study of 215 patients.
    Arthritis Res Ther 2018 Apr 10;20(1):65. Epub 2018 Apr 10.
    Department of Rheumatology, Peking Union Medical College Hospital (West Campus), Chinese Academy of Medical Science & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, No.41 Da Mu Cang, Western District, Beijing, 100032, People's Republic of China.
    Background: The aim of this study was to assess the outcomes of remission induction in patients with IgG4-related disease (IgG4-RD) in our cohort, and to investigate the characteristics, prognosis, and risk factors in the patients failed of remission induction.

    Methods: We prospectively enrolled 215 newly diagnosed patients with IgG4-RD, who were initially treated with glucocorticoid (GC) alone or in combination with immunosuppressive agents (IM), and had at least 6 months of follow up. The therapeutic goals of remission induction were defined as fulfilling each of the following after the 6-month remission induction stage: (1) ≥ 50% decline in the IgG4-RD responder index (RI); (2) GC tapered to maintenance dose; and (3) no relapse during GC tapering. Read More
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    Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis.
    Arthritis Res Ther 2018 Apr 10;20(1):66. Epub 2018 Apr 10.
    Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan.
    Background: Anticitrullinated protein antibodies (ACPA) and citrullinated proteins play key roles in the pathogenesis of rheumatoid arthritis (RA). Many candidate citrullinated antigens have been identified in joints, but citrullinated proteins in sera are mostly uncertain in patients with RA. We explored the expression of citrullinated proteins in joints and sera of experimental arthritis, and we further investigated their specific expression correlated with the disease activity in patients with RA. Read More
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    Dysfunction of regulatory T cells in patients with ankylosing spondylitis is associated with a loss of Tim-3.
    Int Immunopharmacol 2018 Apr 2;59:53-60. Epub 2018 Apr 2.
    Department of Orthopedics, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:
    An expansion of regulatory T cells (Tregs) in ankylosing spondylitis (AS) was observed. However, AS patients continue to exhibit aberrant inflammation. In this study, we collected PBMCs from 26 AS patients and 26 healthy controls, and investigated the functional capacity of Treg cells from these subjects. Read More
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    Adenosine Deaminase activity and HLA-DRB as diagnostic markers for Rheumatoid Arthritis.
    Curr Rheumatol Rev 2018 Apr 5. Epub 2018 Apr 5.
    Pasteur Institute of Iran - Biochemistry Tehran. Iran.
    Background And Objective: Rheumatoid Arthritis (RA) is a chronic multi systemic disorder with the unclarified ethiopathology. Although several markers have been presented for recognition of RA, but none of them has been specific. New markers such as HLA typing and activity of Adenosine deaminase (ADA) isoenzymes could be useful and specific. Read More
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    Colitis Leading to Reactive Arthritis: A Rare Complication Associated With a Common Disease.
    J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618767689. Epub 2018 Mar 30.
    Temple University, Philadelphia, PA, USA.
    The relationship between reactive arthritis and enteric infections caused by , and is well documented. colitis is a less recognized cause of reactive arthritis. We present a case of a 58-year-old woman with colitis complicated by reactive arthritis. Read More
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    Kingella kingae as the Main Cause of Septic Arthritis: Importance of Molecular Diagnosis.
    Pediatr Infect Dis J 2018 Mar 31. Epub 2018 Mar 31.
    Pediatric Infectious Diseases Unit, Gregorio Marañón University Hospital, Madrid, Spain.
    Background: Kingella kingae is an emergent pathogen causing septic arthritis (SA) in children.

    Objectives: To analyze the etiology of SA in children before and after the implementation of universal 16S rRNA gene polymerase chain reaction and sequencing (16SPCR) in synovial fluid.

    Methods: Children ≤ 14 years with acute SA from a Madrid cohort (2002-2013), were reviewed. Read More
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    ACPA IgG galactosylation associates with disease activity in pregnant patients with rheumatoid arthritis.
    Ann Rheum Dis 2018 Apr 3. Epub 2018 Apr 3.
    Department of Rheumatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
    Objectives: Patients with autoantibody-positive rheumatoid arthritis (RA) are less likely to experience pregnancy-induced improvement of RA disease activity (DAS28-C reactive protein (CRP)) compared with patients with autoantibody-negative RA. Anti-citrullinated protein antibodies (ACPAs) are the most specific autoantibodies for RA. We previously demonstrated that disease improvement is associated with changes in total IgG glycosylation, which regulate antibody effector function. Read More
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    [Eperythrozoonosis complicated with hemophagocytic syndrome: report of four cases and review of literature].
    Zhonghua Er Ke Za Zhi 2018 Apr;56(4):303-307
    Department of Rheumatology and Immunology, Children's Hospital Affiliated to Capital Institute of Pediatrics, Beijing 100020, China.
    To analyze the clinical characteristics of eperythrozoonosis complicated with hemophagocytic syndrome (HPS) in 4 children. Four patients diagnosed with eperythrozoonosis complicated with HPS in the Children's Hospital Affiliated Capital Institute of Pediatrics during the period from June 2014 to July 2016 were enrolled. The clinical manifestations, laboratory examination data and therapeutic strategies were analyzed. Read More
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    Safety and effectiveness of iguratimod in patients with rheumatoid arthritis: Final report of a 52-week, multicenter postmarketing surveillance study.
    Mod Rheumatol 2018 Apr 3:1-30. Epub 2018 Apr 3.
    n Sapporo Medical Center NTT EC , Hokkaido , Japan.
    Objective: We evaluated the long-term (52-week) safety and effectiveness of iguratimod in patients with rheumatoid arthritis (RA).

    Methods: This multicenter, prospective, observational study included all evaluable RA patients who received iguratimod since its market launch in 2012. We evaluated adverse events (AEs); adverse drug reactions (ADRs); ADRs of special interest, including liver and renal dysfunctions, interstitial lung disease, gastrointestinal and blood disorders, and infection; and change in Disease Activity Score 28-C-reactive protein at week 52. Read More
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    Influence of large joint involvement on patient-physician discordance in global assessment of rheumatoid arthritis disease activity analyzed by a novel joint index.
    Int J Rheum Dis 2018 Apr 3. Epub 2018 Apr 3.
    Department of Rheumatology, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara Hospital, Kanagawa, Japan.
    Objectives: The discordance between patient global assessment (PGA) and physician global assessment (PhGA) of rheumatoid arthritis (RA) disease activity may be problematic in clinical practice. The aim of this study was to identify determinants of this discordance using a nationwide RA database in Japan (NinJa) with special attention to large joint involvement.

    Methods: We investigated 12 043 adults with RA and used a discordance cutoff of 3 cm. Read More
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    Effect of tumor necrosis factor α inhibitors on spinal radiographic progression in patients with ankylosing spondylitis.
    Int J Rheum Dis 2018 Apr 2. Epub 2018 Apr 2.
    Division of Rheumatology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
    Aim: To evaluate the effect of tumor necrosis factor α inhibitors (TNFi) on spinal radiographic progression in patients with ankylosing spondylitis (AS).

    Methods: Subjects were selected from patients at a single tertiary hospital between 1995 and 2014. Patients who used TNFi with baseline and paired follow-up radiographic data with a minimum interval of 2 years were included. Read More
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    Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study.
    Clin Rheumatol 2018 Apr 3. Epub 2018 Apr 3.
    Department of Rheumatology & Rehabilitation, Faculty of Medicine, Assiut University, Assiut, Egypt.
    Resveratrol (RSV), a naturally occurring polyphenol, has been found to have potent antioxidant, anti-inflammatory, and anticancer effects. Recently, RSV was reported as a new potential agent to suppress inflammation of collagen-induced arthritis in a mouse model. Nevertheless, the clinical benefits of RSV in the management of rheumatoid arthritis (RA) were not studied. Read More
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    Origins of Discordant Responses among 3 Rheumatoid Arthritis Improvement Criteria.
    J Rheumatol 2018 Apr 1. Epub 2018 Apr 1.
    From the Intramural Research Program, US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), US National Institutes of Health (NIH), Bethesda, Maryland, USA. This study was supported by the Intramural Research Program, NIAMS, NIH (ZIA-AR041153), and the US Public Health Service grant RO1-AR45177. M.M. Ward, MD, MPH, Intramural Research Program, NIAMS, NIH; L.C. Guthrie, BSN, Intramural Research Program, NIAMS, NIH; M.I. Alba, MD, Intramural Research Program, NIAMS, NIH; A. Dasgupta, PhD, Intramural Research Program, NIAMS, NIH. Address correspondence to Dr. M.M. Ward, NIAMS/NIH, Building 10 CRC, Room 4-1339, 10 Center Drive, Bethesda, Maryland 20892, USA. E-mail: Accepted for publication December 27, 2017.
    Objective: We examined agreement between the American College of Rheumatology (ACR), European League Against Rheumatism (EULAR), and Simplified Disease Activity Index (SDAI) response criteria in rheumatoid arthritis (RA) and tested whether discordant responses were associated with patients' baseline characteristics or changes in RA activity encapsulated by the different criteria.

    Methods: In a prospective longitudinal study, we examined responses of 243 patients with active RA to escalation of antirheumatic treatment. We computed agreement between pairs of response criteria using κ coefficients and identified patient characteristics associated with unique responses to individual criteria. Read More
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    Poststreptococcal reactive arthritis in Japan.
    J Infect Chemother 2018 Mar 29. Epub 2018 Mar 29.
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan. Electronic address:
    Reactive arthritis after Group A streptococcal infection (poststreptococcal reactive arthritis: PSRA) that does not meet the Jones criteria for acute rheumatic fever (ARF) has been reported as a new entity for over a decade. In Japan there are few reports of PSRA. We encountered four children with arthritis accompanied with Group A streptococcal infection in our department. Read More
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    Neutrophils and redox stress in the pathogenesis of autoimmune disease.
    Free Radic Biol Med 2018 Mar 29. Epub 2018 Mar 29.
    Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, 6 West Derby Street, L7 8TX Liverpool, UK. Electronic address:
    Polymorphonuclear leukocytes, or neutrophils, are specialist phagocytic cells of the innate immune system. Their primary role is host defence against micro-organisms, which they kill via phagocytosis, followed by release of reactive oxygen species (ROS) and proteolytic enzymes within the phagosome. ROS are generated via the action of the NADPH oxidase (also known as NOX2), in a process termed the 'Respiratory Burst'. Read More
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    The impact of patient global assessment in the definition of remission as a predictor of long-term radiographic damage in patients with rheumatoid arthritis: protocol for an individual patient data meta-analysis.
    Acta Reumatol Port 2018 Jan-Mar;43(1):52-60
    Centro Hospitalar e Universitário de Coimbra EPE.
    Background: Remission is the target for management of rheumatoid arthritis (RA) and intensification of immunosuppressive therapy is recommended for those that do not achieve this status. Patient global assessment (PGA) is the single patient reported outcome considered in the American College of Rheumatology/European League Against Rheumatism remission criteria, but its use as target has been questioned. The primary aim of this study is to assess whether excluding PGA from the definition of disease remission changes the association of disease remission with long-term radiographic damage and physical function in patients with RA. Read More
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    Hypoxia, oxidative stress and inflammation.
    Free Radic Biol Med 2018 Mar 27. Epub 2018 Mar 27.
    The Department of Molecular Rheumatology, Trinity College Dublin, Ireland. Electronic address:
    Inflammatory Arthritis is characterized by synovial proliferation, neovascularization and leukocyte extravasation leading to joint destruction and functional disability. Efficiency of oxygen supply to the synovium is poor due to the highly dysregulated synovial microvasculature. This along with the increased energy demands of activated infiltrating immune cells and inflamed resident cells leads to an hypoxic microenvironment and mitochondrial dysfunction. Read More
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    Smoking under hypoxic conditions: a potent environmental risk factor for inflammatory and autoimmune diseases.
    Mil Med Res 2018 Mar 30;5(1):11. Epub 2018 Mar 30.
    School of Biotechnology, Gautam Buddha University, Greater Noida, Gautam Budh Nagar, Uttar Pradesh, 201312, India.
    Autoimmune disease management presents a significant challenge to medical science. Environmental factors potentially increase the risk of developing inflammatory and autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, and lupus. Among various environmental stresses, cigarette smoke and hypoxia have both been reported to lead to an enhanced risk of inflammatory and autoimmune diseases. Read More
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    Smoking quantity determines disease activity and function in Chinese patients with ankylosing spondylitis.
    Clin Rheumatol 2018 Mar 27. Epub 2018 Mar 27.
    State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
    The objective of this study was to systemically and comprehensively evaluate the associations between smoking and disease outcomes in patients with ankylosing spondylitis (AS). Information on smoking, clinical features, and sociodemographic characteristics was collected by a questionnaire administered directly to the patient. Group differences were analyzed by t test or chi-square test. Read More
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    A 4-year non-randomized comparative phase-IV study of early rheumatoid arthritis: integrative anthroposophic medicine for patients with preference against DMARDs versus conventional therapy including DMARDs for patients without preference.
    Patient Prefer Adherence 2018 16;12:375-397. Epub 2018 Mar 16.
    Department of Internal Medicine and Gastroenterology, Filderklinik, Filderstadt, Germany.
    Background: While disease-modifying antirheumatic drugs (DMARDs) are a mainstay of therapy for rheumatoid arthritis (RA), some patients with early RA refuse DMARDs. In anthroposophic medicine (AM), a treatment strategy for early RA without DMARDs has been developed. Preliminary data suggest that RA symptoms and inflammatory markers can be reduced under AM, without DMARDs. Read More
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    Clinical and MRI remission in patients with nonradiographic axial spondyloarthritis who received long-term open-label adalimumab treatment: 3-year results of the ABILITY-1 trial.
    Arthritis Res Ther 2018 Mar 27;20(1):61. Epub 2018 Mar 27.
    AbbVie Inc., North Chicago, IL, USA.
    Background: Adalimumab was effective in treating patients with nonradiographic axial spondyloarthritis (nr-axSpA) in the 12-week ABILITY-1 trial. We present long-term efficacy and safety results of adalimumab from the open-label ABILITY-1 extension, including the relationship between clinical and magnetic resonance imaging (MRI) remission and impact of sustained clinical remission on physical function.

    Methods: Patients received adalimumab 40 mg every other week or placebo for 12 weeks, then open-label adalimumab for up to 144 weeks. Read More
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    MiR-146a G/C rs2910164 variation in South African Indian and Caucasian patients with psoriatic arthritis.
    BMC Med Genet 2018 Mar 27;19(1):48. Epub 2018 Mar 27.
    School of Laboratory Medicine and Medical Sciences, Discipline of Medical Biochemistry and Chemical Pathology, University of KwaZulu-Natal, George Campbell Building - South Entrance, 3rd Floor, King George V Avenue, Howard College Campus, Durban, 4001, South Africa.
    Background: Psoriasis and psoriatic arthritis (PsA) are inflammatory associated autoimmune disorders. MicroRNA (miR)-146a plays a crucial role in regulating inflammation. A single nucleotide polymorphism in the miR-146a gene (rs2910164), aberrantly alters its gene expression and linked with the pathogenesis of several disorders, including psoriasis and PsA. Read More
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