14,283 results match your criteria Reactive Arthritis


Simiao Pill Attenuates Collagen-Induced Arthritis in Rats through Suppressing the ATX-LPA and MAPK Signalling Pathways.

Evid Based Complement Alternat Med 2019 14;2019:7498527. Epub 2019 Mar 14.

Department of Integrated Chinese Traditional and Western Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430070, China.

Objective: Simiao pill (SM), a traditional Chinese formula, has been used as an antirheumatic drug in clinical practice for hundreds of years. Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation and hyperplasia, cartilage destruction, and joint damage. This study was designed to investigate the protective effects of SM on collagen-induced arthritis (CIA) in rats. Read More

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http://dx.doi.org/10.1155/2019/7498527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437962PMC

Efficacy and safety of namilumab, a human monoclonal antibody against granulocyte-macrophage colony-stimulating factor (GM-CSF) ligand in patients with rheumatoid arthritis (RA) with either an inadequate response to background methotrexate therapy or an inadequate response or intolerance to an anti-TNF (tumour necrosis factor) biologic therapy: a randomized, controlled trial.

Arthritis Res Ther 2019 Apr 18;21(1):101. Epub 2019 Apr 18.

Takeda Development Centre, London, UK.

Background: Namilumab (AMG203), an immunoglobulin G1 monoclonal antibody that binds with high affinity to granulocyte-macrophage colony-stimulating factor (GM-CSF), was evaluated in a phase II randomized, double-blind, placebo-controlled study to investigate the efficacy and safety in patients with rheumatoid arthritis (RA) with an inadequate response to methotrexate (MTX-IR) or anti-tumour necrosis factor therapy (TNF-IR).

Methods: Subcutaneous namilumab (20, 80, or 150 mg) or placebo was administered at baseline and weeks 2, 6, and 10 in patients on stable background methotrexate therapy who were with MTX-IR or TNF-IR. Primary endpoint was mean change from baseline in the 28-joint Disease Activity Score, C-reactive protein version (DAS28-CRP) at week 12 comparing each of the three doses of namilumab to placebo. Read More

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http://dx.doi.org/10.1186/s13075-019-1879-xDOI Listing

Randomised, double-blind, phase III study comparing the infliximab biosimilar, PF-06438179/GP1111, with reference infliximab: efficacy, safety and immunogenicity from week 30 to week 54.

RMD Open 2019 28;5(1):e000876. Epub 2019 Mar 28.

Metroplex Clinical Research Center, Dallas, Texas, USA.

Objective: To investigate the efficacy, safety and immunogenicity of PF-06438179/GP1111 (PF-SZ-IFX) compared with European reference infliximab (Remicade; ref-IFX) in patients with moderate-to-severe, active rheumatoid arthritis after continued long-term use of PF-SZ-IFX, and in patients who were switched from ref-IFX to PF-SZ-IFX.

Methods: REFLECTIONS B537-02 was a double-blind, active-controlled, multinational study in which patients (N=650) were initially randomised to PF-SZ-IFX or ref-IFX for 30 weeks (treatment period [TP] 1). During weeks 30-54 (TP2), the PF-SZ-IFX group (n=280) continued treatment with PF-SZ-IFX (PF-SZ-IFX/PF-SZ-IFX) and patients in the ref-IFX group (n=286) were rerandomised (1:1) to continue ref-IFX (ref-IFX/ref-IFX) (n=143) or switch to PF-SZ-IFX (ref-IFX/PF-SZ-IFX) (n=143) for a further 24 weeks. Read More

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http://dx.doi.org/10.1136/rmdopen-2018-000876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446180PMC

Re-treatment with abatacept plus methotrexate for disease flare after complete treatment withdrawal in patients with early rheumatoid arthritis: 2-year results from the AVERT study.

RMD Open 2019 8;5(1):e000840. Epub 2019 Feb 8.

Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands.

Objectives: To complete reporting of outcomes after total withdrawal of all rheumatoid arthritis (RA) therapy and re-treatment after flare in Assessing Very Early Rheumatoid arthritis Treatment study (NCT01142726).

Methods: Patients with early RA were initially randomised to double-blind, weekly subcutaneous abatacept plus methotrexate, or abatacept or methotrexate monotherapy. At month 12, patients with Disease Activity Score (DAS)28 C reactive protein (CRP) <3. Read More

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http://dx.doi.org/10.1136/rmdopen-2018-000840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446179PMC
February 2019

Silicon intake and plasma level and their relationships with systemic redox and inflammatory markers in rheumatoid arthritis patients.

Adv Clin Exp Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Food Science and Dietetics, Wroclaw Medical University, Poland.

Background: The nutritional significance of silicon for the human body is highlighted by a continually growing body of evidence. In conditions of excessive reactive oxygen species and upregulated immune response, silicon has been observed to provide benefits, but its role in redox and inflammatory status has not yet been examined in rheumatoid arthritis (RA).

Objectives: The aim of this study was to assess the relationship of silicon intake and plasma level to systemic indices of redox status and inflammation in patients with RA. Read More

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http://dx.doi.org/10.17219/acem/105380DOI Listing
April 2019
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Aberrant expression of microRNAs in peripheral blood mononuclear cells as candidate biomarkers in patients with axial spondyloarthritis.

Int J Rheum Dis 2019 Apr 16. Epub 2019 Apr 16.

Department of Rheumatology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Objectives: Axial spondyloarthritis (axSpA) is a chronic inflammatory arthritis involving the axial skeleton. Recent evidence suggests that microRNAs (miRNAs) play a critical role in ankylosing spondylitis (AS). In this study, we aimed to investigate whether miR-17-5p, miR-27a, miR-29a and miR-126-3p can be verified as potential biomarkers of axSpA. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1756-185X.13
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http://dx.doi.org/10.1111/1756-185X.13563DOI Listing
April 2019
5 Reads

Value of serum procalcitonin for the diagnosis of bacterial septic arthritis in daily practice in rheumatology.

Clin Rheumatol 2019 Apr 16. Epub 2019 Apr 16.

CHRU Jean Minjoz, Service de Rhumatologie, 3 Boulevard Alexandre Fleming, 25000, Besancon, France.

Introduction/objectives: Septic arthritis is a diagnostic and therapeutic emergency because of a high morbidity and mortality. Nevertheless, the etiologic diagnosis is often difficult. The aim of our study was to determine if serum procalcitonin was a discriminatory biomarker in case of arthritis of undetermined etiology. Read More

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http://dx.doi.org/10.1007/s10067-019-04542-0DOI Listing
April 2019
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Conversion to total hip arthroplasty in posttraumatic arthritis: short-term clinical outcomes.

Orthop Res Rev 2019 4;11:41-46. Epub 2019 Feb 4.

Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran,

Background: Fractures of the acetabulum are challenging and very difficult to treat, and even after fixation, they can lead to posttraumatic arthritis. Total hip arthroplasty (THA) has been the most common surgery performed for the complications of posttraumatic arthritis in this group of patients.

Aim: In this article, it is aimed to assess the functional results and complications of the conversion to THA for posttraumatic arthritis after acetabular fracture. Read More

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https://www.dovepress.com/conversion-to-total-hip-arthroplas
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http://dx.doi.org/10.2147/ORR.S184590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442317PMC
February 2019
2 Reads

The RANKL-RANK Axis: A Bone to Thymus Round Trip.

Front Immunol 2019 29;10:629. Epub 2019 Mar 29.

Milan Unit, Institute for Genetic and Biomedical Research (CNR-IRGB), Milan, Italy.

The identification of Receptor activator of nuclear factor kappa B ligand (RANKL) and its cognate receptor Receptor activator of nuclear factor kappa B (RANK) during a search for novel tumor necrosis factor receptor (TNFR) superfamily members has dramatically changed the scenario of bone biology by providing the functional and biochemical proof that RANKL signaling via RANK is the master factor for osteoclastogenesis. In parallel, two independent studies reported the identification of mouse RANKL on activated T cells and of a ligand for osteoprotegerin on a murine bone marrow-derived stromal cell line. After these seminal findings, accumulating data indicated RANKL and RANK not only as essential players for the development and activation of osteoclasts, but also for the correct differentiation of medullary thymic epithelial cells (mTECs) that act as mediators of the central tolerance process by which self-reactive T cells are eliminated while regulatory T cells are generated. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00629
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http://dx.doi.org/10.3389/fimmu.2019.00629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450200PMC
March 2019
2 Reads

Managing of musculoskeletal infections in children.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):179-186

Department of Orthopaedics and Traumatology, Institute of Scientific Research, Children's Hospital Bambino Gesù, Rome, Italy.

Objective: Epidemiological features of musculoskeletal infections are in continuous evolution. The incidence of emerging causative pathogen is arising. Nevertheless, up to 50% of osteoarticular infections shows negative cultures. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17488DOI Listing
April 2019
1 Read

Essential Kinases and Transcriptional Regulators and Their Roles in Autoimmunity.

Biomolecules 2019 Apr 10;9(4). Epub 2019 Apr 10.

Department of Internal Medicine, Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH 43201, USA.

Kinases and transcriptional regulators are fundamental components of cell signaling that are expressed on many types of immune cells which are involved in secretion of cytokines, cell proliferation, differentiation, and apoptosis. Both play important roles in biological responses in health as well as in illnesses such as the autoimmune diseases which comprise at least 80 disorders. These diseases are caused by complex genetic and environmental interactions that lead to a breakage of immunologic tolerance and a disruption of the balance between self-reactive cells and regulatory cells. Read More

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http://dx.doi.org/10.3390/biom9040145DOI Listing
April 2019
1 Read

Emerging role of air pollution in autoimmune diseases.

Autoimmun Rev 2019 Apr 5. Epub 2019 Apr 5.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road, Hefei, Anhui, China. Electronic address:

Autoimmune diseases (ADs) are a broad spectrum of disorders featured by the body's immune responses being directed against its own tissues, resulting in prolonged inflammation and subsequent tissue damage. Recently, the exposure to ambient air pollution has been implicated in the occurrence and development of ADs. Mechanisms linking air pollution exposures and ADs mainly include systemic inflammation, increased oxidative stress, epigenetic modifications induced by exposures and immune response caused by airway damage. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.12.010DOI Listing
April 2019
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Exposure-response modeling of tocilizumab in rheumatoid arthritis using continuous composite measures and their individual components.

Br J Clin Pharmacol 2019 Apr 8. Epub 2019 Apr 8.

Department of Pharmacy & Pharmacology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

Aims: Tocilizumab has a direct effect on inflammatory markers. Therefore, composite measures for disease activity assessment in rheumatoid arthritis (RA) using these inflammatory markers may not be suitable for tocilizumab treatment. We used a modeling approach to describe tocilizumab exposure-response relationship and to investigate the different dynamics of the individual components of the routinely used continuous composite measures. Read More

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http://dx.doi.org/10.1111/bcp.13954DOI Listing
April 2019
3 Reads

A clinical model for identifying an inflammatory phenotype in mood disorders.

J Psychiatr Res 2019 Feb 10;113:148-158. Epub 2019 Feb 10.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA; VA Palo Alto Health Care System, Palo Alto, CA, USA.

Increasingly, clinical research has found inflammatory correlates of psychiatric disorders, particularly mood symptomatology. Biological measures may provide greater precision in many cases and may capture clinically-relevant inflammatory signposts, such as central obesity risk, inflammation-associated co-morbid medical conditions, or proinflammatory lifestyle choices. In order to expand understanding of the role of inflammation in mood disorders, we propose a more inclusive clinical model for capturing an inflammatory phenotype of depression by identifying clinically-relevant inflammatory phenotypes grounded in biology. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.02.005DOI Listing
February 2019
3 Reads

How Streptococcus suis serotype 2 attempts to avoid attack by host immune defenses.

J Microbiol Immunol Infect 2019 Mar 27. Epub 2019 Mar 27.

College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China; Postdoctoral Research Base, Henan Institute of Science and Technology, Xinxiang, China. Electronic address:

Streptococcus suis (S. suis) type 2 (SS2) is an important zoonotic pathogen that causes swine streptococcosis, a widespread infectious disease that occurs in pig production areas worldwide and causes serious economic losses in the pork industry. Hosts recognize pathogen-associated molecular patterns (PAMPs) through pattern recognition receptors (PRRs) to activate both innate and acquired immune responses. Read More

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http://dx.doi.org/10.1016/j.jmii.2019.03.003DOI Listing
March 2019
3 Reads

Pediatric Septic Arthritis of the Knee: Predictors of Septic Hip Do Not Apply.

J Pediatr Orthop 2019 Apr 3. Epub 2019 Apr 3.

Washington University School of Medicine, Pediatric and Adolescent Orthopedic Surgery Washington University Orthopaedics, St. Louis, MO.

Background: The early diagnosis of pediatric septic arthritis is paramount to the prevention of long-term sequela. The purpose of this study is to investigate if the commonly used criteria developed by Kocher and colleagues for hip septic arthritis can be used for screening children with suspected septic knee.

Methods: We retrospectively reviewed the charts of patients under the age of 19, between June 2002 to June 2017, who presented to a major tertiary-care children's hospital with septic knee. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001377DOI Listing

Clinicopathological features of clinical methotrexate-related lymphoproliferative disorders.

Leuk Lymphoma 2019 Apr 5:1-8. Epub 2019 Apr 5.

a Department of Hematology , Saitama Medical Center, Saitama Medical University , Saitama , Japan.

Methotrexate (MTX) is one of the potent drugs for autoimmune diseases (ADs), especially for rheumatoid arthritis. Recent studies suggest that MTX should be immediately withdrawn when patients with AD develop lymphoproliferative disorder (LPD). However, biopsy cannot be performed for diagnosis because LPD regresses quickly after MTX withdrawal, thus making clinical MTX-LPD (c-MTX-LPD) challenging to diagnose. Read More

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http://dx.doi.org/10.1080/10428194.2019.1585841DOI Listing
April 2019
3 Reads

Markers for oxidative stress in the synovial fluid of Thoroughbred horses with carpal bone fracture.

J Equine Sci 2019 Mar 3;30(1):13-16. Epub 2019 Apr 3.

Racehorse Hospital, Miho Training Center, Japan Racing Association, Ibaraki 300-0493, Japan.

Arthritis is thought to cause oxidative stress in synovial fluid in humans, but there have been few reports in horses. To evaluate oxidative stress in synovial fluid in horses, this study used 19 horses with unilateral fracture of the carpal joint bone. Synovial fluid was collected from the carpal joint on the fracture (arthritis group) and contralateral (control group) sides. Read More

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http://dx.doi.org/10.1294/jes.30.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445753PMC
March 2019
1 Read

Clinical spectrum of post-streptococcal reactive arthritis (PSRA) revisited: Juvenile versus adult-onset disease.

Int J Rheum Dis 2019 Apr 3;22(4):750-751. Epub 2019 Apr 3.

Department of Clinical Immunology and Rheumatology, Christian Medical College & Hospital, Vellore, India.

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http://dx.doi.org/10.1111/1756-185X.13524DOI Listing
April 2019
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LRG is a novel inflammatory marker clinically useful for the evaluation of disease activity in rheumatoid arthritis and inflammatory bowel disease.

Immunol Med 2018 Jun 11;41(2):62-67. Epub 2018 Sep 11.

a Center for Intractable Immune Disease, Kochi Medical School , Kochi University , Nankoku , Japan.

By proteomic screening of sera obtained from patients with rheumatoid arthritis (RA), we previously identified leucine rich α2 glycoprotein (LRG) as a possible marker for inflammation. Unlike C-reactive protein (CRP), a biomarker widely used to evaluate inflammation, LRG is induced not only by IL-6 but also by other proinflammatory cytokines. In addition, LRG is upregulated not only in liver but also in local inflammatory sites. Read More

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http://dx.doi.org/10.1080/13497413.2018.1481582DOI Listing
June 2018
4 Reads

State of care for patients with systemic autoinflammatory diseases - Results of a tertiary care survey.

World Allergy Organ J 2019 14;12(3):100019. Epub 2019 Mar 14.

Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Germany.

Background: Systemic autoinflammatory diseases (SAIDs) are rare debilitating disorders of which there is limited awareness and a significant delay in diagnosis. There is no uniform approach in the diagnosis and treatment of these disorders and the real life state of SAID patient care is poorly characterized. The aim of this study was to obtain data on the epidemiology, state of care and the perception of physicians who are involved in the care of SAID patients. Read More

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http://dx.doi.org/10.1016/j.waojou.2019.100019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439415PMC
March 2019
6 Reads

Hyaluronic Acid-Modified and TPCA-1-Loaded Gold Nanocages Alleviate Inflammation.

Authors:
Jingnan Zhao

Pharmaceutics 2019 Mar 25;11(3). Epub 2019 Mar 25.

Biotechnology G2018, School of International Education, Henan University of Technology, No. 100 Lianhua Street, Zhengzhou 450001, China.

Gold nanocages (AuNCs) are biocompatible and porous nanogold particles that have been widely used in biomedical fields. In this study, hyaluronic acid (HA) and peptide- modified gold nanocages (HA-AuNCs/T/P) loaded with 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide (TPCA-1) were prepared to investigate their potential for combating inflammation. TPCA-1 was released from AuNCs, intracellularly when HA was hydrolyzed by hyaluronidase. Read More

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http://dx.doi.org/10.3390/pharmaceutics11030143DOI Listing
March 2019
2 Reads

Incidental papillary thyroid cancer diagnosis in patient with adult-onset Still's disease-like manifestations.

Authors:
R Tirri D Capocotta

Reumatismo 2019 Apr 1;71(1):42-45. Epub 2019 Apr 1.

Unit of Rheumatology, Department of Clinical and Sperimental Internal Medicine, Luigi Vanvitelli University, Napoli.

Adult onset Still's disease (AOSD) is a systemic inflammatory disease characterized primarily by a triad consisting of daily fever, arthritis and maculopapular exanthema. The pathogenesis and etiology of AOSD are unknown and the diagnosis, which can be very challenging, is often made by exclusion. Here, we report a case of a 61-year-old woman with a history of mild psoriatic arthritis, fever, arthritis and maculopapular exanthema. Read More

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http://dx.doi.org/10.4081/reumatismo.2019.1118DOI Listing
April 2019
1 Read

What potential do magnetic iron oxide nanoparticles have for the treatment of rheumatoid arthritis?

Authors:
Lin Wu Song Shen

Nanomedicine (Lond) 2019 Apr 29;14(8):927-930. Epub 2019 Mar 29.

Department of Pharmaceutics, School of Pharmaceutical Science, Jiangsu University, Zhenjiang 212013, China.

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http://dx.doi.org/10.2217/nnm-2019-0071DOI Listing
April 2019
1 Read

An open-label extension study to demonstrate long-term safety and efficacy of ABP 501 in patients with rheumatoid arthritis.

Arthritis Res Ther 2019 Mar 29;21(1):84. Epub 2019 Mar 29.

Biosimilars Development, Amgen Inc., Thousand Oaks, CA, USA.

Background: ABP 501 was evaluated in a phase 3 single-arm, open-label extension (OLE) study to collect additional safety and efficacy data in patients with rheumatoid arthritis (RA).

Methods: Subjects completing the final visit in the parent phase 3 randomized, double-blind, controlled equivalence study comparing the efficacy and safety of the biosimilar ABP 501 with adalimumab reference product (RP) were enrolled in this open-label extension (OLE) study. All subjects received 40 mg ABP 501 every other week for 68 weeks. Read More

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http://dx.doi.org/10.1186/s13075-019-1857-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440148PMC
March 2019
1 Read

Biomedical health profiles of unpaid family carers in an urban population in South Australia.

PLoS One 2019 28;14(3):e0208434. Epub 2019 Mar 28.

Population Research & Outcome Studies, Discipline of Medicine, The University of Adelaide, Adelaide, South Australia, Australia.

Objectives: To compare the biomedical health profile and morbidity of adult carers with non-carers.

Methods: The North West Adelaide Health Study (NWAHS) is a representative population-based longitudinal biomedical cohort study of 4056 participants aged 18 years and over at Stage One. Informal (unpaid) carers were identified in Stage 3 of the project (2008-2010). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208434PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438668PMC

Evolving patterns of reactive arthritis.

Clin Rheumatol 2019 Mar 27. Epub 2019 Mar 27.

Department of Medicine, Schulich School of Medicine & Dentistry, Western University, London, Canada.

Objective: To characterize rheumatologists' perspectives on evolving trends of reactive arthritis (ReA).

Methods: After ethics approval, 548 members of the Canadian Rheumatology Association were surveyed with 37 questions covering their demographic information, subspecialty, level of experience, practice setting and opinions on prevalence, treatment, and causes of ReA. Results were analyzed with descriptive statistics. Read More

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http://dx.doi.org/10.1007/s10067-019-04522-4DOI Listing
March 2019
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α-2,3-Sialyltransferase 1 and neuraminidase-3 from monocytes in patients with rheumatoid arthritis correlate with disease activity measures: A pilot study.

J Chin Med Assoc 2019 Mar;82(3):179-185

Division of Rheumatology, Allergy, and Immunology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, ROC.

Background: We decided to study the association of monocyte α-2,3-sialyltransferase 1 (ST3Gal-1), neuraminidase-3 (Neu3), α-2,6-sialyltransferase 1 (ST6Gal-1), and neuraminidase-1 (Neu1) levels with disease activity score 28 (DAS28) in human rheumatoid arthritis (RA), considering that mouse monocytes' sialic acid (SIA) levels relate to their phagocytosis and IgG binding ability.

Methods: ST3Gal-1, Neu3, ST6Gal-1, Neu1, α-2,3-SIA, and α-2,6-SIA levels on RA peripheral blood monocytes, T cells, and polymorphonuclear cells were determined by using fluorochrome-conjugated anti-cell-specific marker antibodies and fluorochrome-conjugated anti-enzyme antibodies. Simple correlation and linear regression were used to correlate enzyme levels with DAS28. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000027DOI Listing
March 2019
1 Read

Patients with a History of Treated Septic Arthritis are at High Risk of Periprosthetic Joint Infection after Total Joint Arthroplasty.

Clin Orthop Relat Res 2019 Mar 14. Epub 2019 Mar 14.

A. A. Sultan, B. Mahmood, L. T. Samuel, J. George, M. Faour, A. K. Klika, Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio, USA C. E. Pelt, M. B. Anderson, Department of Orthopaedic Surgery, Utah University Medical Center, Salt Lake City, UT, USA C. A. Higuera, Department of Orthopaedic Surgery, Cleveland Clinic, Weston, FL, USA.

Background: In patients undergoing total joint arthroplasty (TJA), increasing attention has been directed recently toward identifying specific patient-related risk factors that may predispose patients to periprosthetic joint infection (PJI). Currently, it is unclear whether having a history of a treated native septic arthritis is a risk factor for PJI after TJA in the same joint. Previous studies have reported contradictory evidence and results varied between a substantially higher rates of PJIs to very low or no reported PJIs. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000688DOI Listing
March 2019
1 Read
2.765 Impact Factor

[Serum nesfatin-1 as a marker of systemic inflammation in rheumatoid arthritis.]

Klin Lab Diagn 2019 ;64(1):53-56

The research institute of clinical and experimental rheumatology Named after A.B. Zborovsky, 400138, Volgograd, Russian Federation.

The purpose of this study was to determine the level of nesfatin-1 (NF-1) in the blood serum of healthy volunteers and patients with rheumatoid arthritis (RA) to establish the threshold for normal values of this parameter and to reveal the relationship between the level of NF-1 and clinical manifestations of RA. We examined 170 people, of which 110 patients with RA and 60 donors who made up the comparison group. The mean level of serum nesfatin-1 in healthy subjects was 31. Read More

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http://dx.doi.org/10.18821/0869-2084-2019-64-1-53-56DOI Listing
January 2019
1 Read

Clinical characteristics of rheumatoid arthritis patients with peripheral neuropathy and potential related risk factors.

Clin Rheumatol 2019 Mar 25. Epub 2019 Mar 25.

Department of Rheumatology, Linyi People's Hospital, No. 27 East Jiefang Road, Linyi, 276000, Shandong, China.

Objectives: To investigate potential risk factors of peripheral neuropathy (PN) in rheumatoid arthritis patients (RA).

Methods: Eighty-eight patients with RA were enrolled in this study, including patients with PN (n = 44; 28 patients with multiple nerves (MN) involvement and 16 patients with single nerve (SN) involvement) and without (n = 44) peripheral neuropathy were enrolled. Their clinical features were comprehensively collected including symptoms/signs, lab results, electromyogram data. Read More

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http://link.springer.com/10.1007/s10067-019-04521-5
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http://dx.doi.org/10.1007/s10067-019-04521-5DOI Listing
March 2019
4 Reads

Serum-based soluble markers differentiate psoriatic arthritis from osteoarthritis.

Ann Rheum Dis 2019 Mar 25. Epub 2019 Mar 25.

Division of Rheumatology, Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada

Objectives: We aimed to identify soluble biomarkers that differentiate psoriatic arthritis (PsA) from osteoarthritis (OA).

Methods: Markers of cartilage metabolism (cartilage oligomeric matrix protein [COMP], hyaluronan), metabolic syndrome (adiponectin, adipsin, resistin, hepatocyte growth factor [HGF], insulin, leptin) and inflammation (C-reactive protein [CRP], interleukin-1β [IL-1β], IL-6, IL-8, tumour necrosis factor alpha [TNFα], monocyte chemoattractant protein-1 [MCP-1], nerve growth factor [NGF]) were compared in serum samples from 201 patients with OA, 77 patients with PsA and 76 controls. Levels across the groups were compared using the Kruskal-Wallis test. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214737DOI Listing
March 2019
1 Read

Effects of Baicalin on piglet monocytes involving PKC-MAPK signaling pathways induced by Haemophilus parasuis.

BMC Vet Res 2019 Mar 25;15(1):98. Epub 2019 Mar 25.

Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM, 87131, USA.

Background: Haemophilus parasuis (HPS) is the causative agent of Glässer's disease, characterized by arthritis, fibrinous polyserositis and meningitis, and resulting in worldwide economic losses in the swine industry. Baicalin (BA), a commonly used traditional Chinese medication, has been shown to possess a series of activities, such as anti-bacterial, anti-viral, anti-tumor, anti-oxidant and anti-inflammatory activities. However, whether BA has anti-apoptotic effects following HPS infection is unclear. Read More

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http://dx.doi.org/10.1186/s12917-019-1840-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434632PMC
March 2019
2 Reads

Evidence of differential microbiomes in healing versus non-healing diabetic foot ulcers prior to and following foot salvage therapy.

J Orthop Res 2019 Mar 25. Epub 2019 Mar 25.

Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, New York.

Diabetic foot ulcers (DFU) contribute to 80% of lower extremity amputations. Although physicians currently rely on clinical signs along with non-specific biomarkers of infection, such as erythrocyte sedimentation rate and C-reactive protein, to diagnose and monitor DFU, there is no specific and sensitive measure available to monitor or prognosticate the success of foot salvage therapy (FST). To address this we performed a prospective, observational microbiome analysis to test the hypotheses that: (i) the initial microbiomes of healed versus non-healed DFU are distinct; (ii) the microbial load, diversity and presence of pathogenic organism of the DFU change in response to antibiotics treatment; and (iii) the changes in the DFU microbiome during treatment are prognostic of clinical outcome. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jor.24279
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http://dx.doi.org/10.1002/jor.24279DOI Listing
March 2019
10 Reads

Calcium pyrophosphate dihydrate crystal deposition disease and MRSA septic arthritis of the atlantoaxial joint in a patient with Tourette syndrome.

BMJ Case Rep 2019 Mar 22;12(3). Epub 2019 Mar 22.

Department of Medicine, University of Illinois College of Medicine at Peoria, Peoria, Illinois, USA.

A 45-year-old male patient with Tourette syndrome presented to the emergency department with worsening neck pain and stiffness of 1-week duration. Associated symptoms included headache, hoarse voice, trismus and odynophagia. The patient was haemodynamically stable without fevers or leucocytosis. Read More

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http://dx.doi.org/10.1136/bcr-2018-228102DOI Listing
March 2019
2 Reads

The impact of physical activity on serum levels of inflammatory markers in rheumatoid arthritis: a systematic literature review.

Rheumatol Int 2019 Mar 21. Epub 2019 Mar 21.

Department of Orthopaedics, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

This review aims to determine the specific effects of PA on systemic levels of interleukins and inflammatory markers. A systematic literature search was conducted in three computerized bibliographic databases (Medline, Embase, CENTRAL) to identify randomized controlled trials and matched case studies. Applied key words were: RA and PA including the terms exercise, exercise therapy, gymnastics and exercise movement techniques. Read More

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http://dx.doi.org/10.1007/s00296-019-04284-xDOI Listing
March 2019
4 Reads

Exenatide Ameliorates Inflammatory Response in Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes.

IUBMB Life 2019 Mar 21. Epub 2019 Mar 21.

Department of Orthopedics, The first Affiliated Hospital of Soochow University, Suzhou, China.

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of unknown etiology characterized by degradation of cartilage and bone, accompanied by unimpeded proliferation of synoviocytes of altered phenotype. In the present study, we investigated the involvement of the glucagon-like peptide 1 (GLP-1) receptor on human fibroblast-like synoviocytes (FLS) in the pathogenesis of RA using the selective GLP-1 agonist exenatide, a licensed drug used for the treatment of type 2 diabetes. Our results indicate that exenatide may play a role in regulating tumor necrosis factor-α-induced mitochondrial dysfunction by increasing mitochondrial membrane potential, oxidative stress by reducing the production of reactive oxygen species, the expression of NADPH oxidase 4, expression of matrix metalloproteinase (MMP)-3 and MMP-13, release of proinflammatory cytokines including interleukin-1β (IL-1β), IL-6, monocyte chemoattractant protein-1, and high-mobility group protein 1, as well as activation of the p38/nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor, α/nuclear factor κB signaling pathway in primary human RA FLS. Read More

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http://dx.doi.org/10.1002/iub.2031DOI Listing
March 2019
2 Reads

Case 268.

Radiology 2019 Apr;291(1):259-260

From the Department of Radiology, Norfolk and Norwich University Hospitals, Colney Lane, Norwich NR4 7UY, England.

History A 65-year-old man presented to the emergency department with a 1-week history of constipation, which was associated with increasing abdominal distention and not passing flatus. Four weeks prior to the current admission he had been diagnosed with metastatic primary adenocarcinoma of the appendix. One week ago, he had been hospitalized with small-bowel obstruction, for which he required laparotomy and loop ileostomy. Read More

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http://dx.doi.org/10.1148/radiol.2019170367DOI Listing
April 2019
2 Reads

Inflammatory disease and C-reactive protein in relation to therapeutic ionising radiation exposure in the US Radiologic Technologists.

Sci Rep 2019 Mar 20;9(1):4891. Epub 2019 Mar 20.

Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892-9778, USA.

Chronic inflammation underlies many autoimmune diseases, including hypothyroidism, hyperthyroidism, and rheumatoid arthritis, also type-2 diabetes and osteoarthritis. Associations have been suggested of high-dose ionising radiation exposure with type-2 diabetes and elevated levels of C-reactive protein, a marker of chronic inflammation. In this analysis we used a proportional hazards model to assess effects of radiotherapy on risks of subsequent inflammatory disease morbidity in 110,368 US radiologic technologists followed from a baseline survey (1983-1989/1994-1998) through 2008. Read More

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http://www.nature.com/articles/s41598-019-41129-w
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http://dx.doi.org/10.1038/s41598-019-41129-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426979PMC
March 2019
6 Reads

Autoreactive B-lymphocytes in SLE and RA patients: Isolation and characterisation using extractable nuclear and citrullinated antigens bound to immunobeads.

Eur J Immunol 2019 Mar 20. Epub 2019 Mar 20.

Servicio de Inmunología, UGC de Hematología, Inmunología y Genética, Hospital Universitario Puerta del Mar (HUPM), Cádiz, Spain.

Systemic lupus erythematosus and rheumatoid arthritis are autoimmune diseases characterised by B-cell hyperactivation and production of autoantibodies (AutoAbs) against various self-antigens, including extractable nuclear antigens and citrullinated peptides. Therefore, B lymphocytes and antibody-secreting cells are considered relevant targets for therapies. However, isolation and characterisation of auto-reactive specific B lymphocytes are limited, primarily due to technical issues. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.20184806
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http://dx.doi.org/10.1002/eji.201848065DOI Listing
March 2019
5 Reads

The autoantibody response to cyclic citrullinated collagen type II peptides in rheumatoid arthritis.

Rheumatology (Oxford) 2019 Mar 19. Epub 2019 Mar 19.

Department of Medical Biochemistry and Biophysics, Section for Medical Inflammation Research, Karolinska Institutet, Stockholm, Sweden.

Objectives: The detection of anti-citrullinated peptide antibodies (ACPAs) is a serological hallmark of RA. Autoantibodies reactive with collagen type II (CII) are present in RA sera and synovial fluid and are potentially pathogenic. Here, we investigate the prevalence and specificity of the autoantibody responses to defined citrullinated cyclic peptides derived from CII in a China RA cohort. Read More

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http://dx.doi.org/10.1093/rheumatology/kez073DOI Listing
March 2019
3 Reads
4.475 Impact Factor

Evaluation of foot functionality in cases of rheumatoid arthritis through the FFI-BR and FHSQ-BR questionnaires: a cross-sectional observational study.

Sao Paulo Med J 2018 Nov-Dec;136(6):520-524

MD, PhD. Professor, Department of Rheumatology, Hospital Universitário Evangélico de Curitiba, Curitiba (PR), Brazil.

Background: Rheumatoid arthritis (RA) can affect the feet, thus compromising the patient's gait and autonomy. In this study, we investigated foot disability in RA patients using the Brazilian versions of the Foot Health Status Questionnaire (FHSQ-BR) and Foot Function Index (FFI-BR).

Design And Setting: Cross-sectional, observational study conducted in a tertiary care hospital. Read More

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http://dx.doi.org/10.1590/1516-3180.2018.0175161118DOI Listing
September 2018
1 Read

Immunopathogenic Mechanisms and Novel Immune-Modulated Therapies in Rheumatoid Arthritis.

Int J Mol Sci 2019 Mar 16;20(6). Epub 2019 Mar 16.

Department of Microbiology and Immunology, National Defense Medical Center, No. 161, Section 6, MinChuan East Road, Neihu, Taipei City 114, Taiwan.

Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease of unknown etiology. It is characterized by the presence of rheumatoid factor and anticitrullinated peptide antibodies. The orchestra of the inflammatory process among various immune cells, cytokines, chemokines, proteases, matrix metalloproteinases (MMPs), and reactive oxidative stress play critical immunopathologic roles in the inflammatory cascade of the joint environment, leading to clinical impairment and RA. Read More

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http://dx.doi.org/10.3390/ijms20061332DOI Listing
March 2019
1 Read

Pharmacodynamic Monitoring of Biological Therapies in Chronic Inflammatory Diseases.

Ther Drug Monit 2019 04;41(2):131-141

Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, University of Leuven, Leuven, Belgium.

Background: Psoriasis, psoriatic arthritis, spondyloarthritis, rheumatoid arthritis, ulcerative colitis, and Crohn disease share similar underlying pathophysiological processes, providing the opportunity to treat the patients using similar biological therapies. Failure of biological treatments due to underexposure can be managed by therapeutic drug monitoring. Adjusting the treatment based on pharmacokinetic monitoring can be further improved by taking pharmacodynamic parameters such as clinical and molecular markers into account. Read More

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http://dx.doi.org/10.1097/FTD.0000000000000571DOI Listing
April 2019
1 Read

Painless gouty tophus in the nasal bridge: A case report and literature review.

Medicine (Baltimore) 2019 Mar;98(11):e14850

School of Medicine, Chang Gung University, Taoyuan.

Rationale: A gouty tophus, arising from the deposition of monosodium urate crystals (MSU), rarely occurs in the nasal bridge. There have been only 7 documented cases of a gouty tophus in the nasal bridge from 1978 to 2018 in English-language literature.

Patient Concerns: A 65-year-old male had a chief complaint of a lump in the nasal bridge that was slowly growing for over 1 year. Read More

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http://dx.doi.org/10.1097/MD.0000000000014850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426609PMC
March 2019
1 Read

Evaluation and Management of Septic Arthritis and its Mimics in the Emergency Department.

West J Emerg Med 2019 Mar 6;20(2):331-341. Epub 2018 Dec 6.

Rush University Medical Center, Department of Emergency Medicine, Chicago, Illinois.

Septic arthritis is a dangerous medical condition associated with significant morbidity and mortality. However, the differential diagnosis can be broad with conditions that mimic this disease and require different evaluation and treatment. This narrative review presents the emergency medicine evaluation and management, as well as important medical conditions that may mimic this disease. Read More

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http://dx.doi.org/10.5811/westjem.2018.10.40974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404712PMC
March 2019
1 Read

Study of correlation of level of expression of Wnt signaling pathway inhibitors sclerostin and dickkopf-1 with disease activity and severity in rheumatoid arthritis patients.

Drug Discov Ther 2019 ;13(1):22-27

Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University.

This study was done with aim to assess the serum sclerostin and dickkopf-1 (DKK-1) level in patients of rheumatoid arthritis (RA) and to correlate their level with disease activity and bone mineral density. Fifty patients of RA and equal age and sex matched healthy controls were included in the study. Patients were evaluated clinically and investigated with routine blood tests along with rheumatoid factor (RF), anti-citrullinated protein antibody (anti-CCP), radiographs and bone mineral density (BMD). Read More

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https://www.jstage.jst.go.jp/article/ddt/13/1/13_2019.01011/
Publisher Site
http://dx.doi.org/10.5582/ddt.2019.01011DOI Listing
January 2019
5 Reads

Urethral diverticulum in pregnancy: a case report.

Authors:
Frida M Carswell

Int Urogynecol J 2019 Mar 16. Epub 2019 Mar 16.

Department of Obstetrics and Gynaecology, Maitland Hospital, Maitland, NSW, Australia.

Introduction And Hypothesis: Urethral diverticulum in pregnancy is a rare finding and difficult to diagnose. The classical triad of dysuria, dyspareunia and dribbling of urine is found in a minority of women.

Methods: A young woman presented during the first trimester of pregnancy with vaginal and suprapubic pain as well as voiding difficulty. Read More

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http://dx.doi.org/10.1007/s00192-019-03890-4DOI Listing
March 2019
1 Read

ERAMRS: a new MR scoring system for early rheumatoid arthritis of the wrist.

Eur Radiol 2019 Mar 14. Epub 2019 Mar 14.

Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, N.T., Hong Kong.

Purpose: To (i) devise a new semi-quantitative scoring system known as Early Rheumatoid Arthritis Magnetic Resonance Score (ERAMRS) to assess inflammation of the wrist on magnetic resonance imaging in early rheumatoid arthritis and to (ii) test ERAMRS and other MR scoring systems against everyday used clinical scorings.

Materials And Methods: One hundred six treatment-naïve patients (81 females, 25 males, mean age 53 ± 12 years) with early rheumatoid arthritis (ERA) underwent clinical/serological testing as well as 3-T MRI examination of the most symptomatic wrist. Clinical assessment included Disease Activity Score-28 and Health Assessment Questionnaire; erythrocyte sedimentation rate and C-reactive protein were measured. Read More

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http://dx.doi.org/10.1007/s00330-019-06060-8DOI Listing
March 2019
3 Reads