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    Mapping Quality of Life (EQ-5D) from DAPsA, Clinical DAPsA and HAQ in Psoriatic Arthritis.
    Patient 2017 Nov 21. Epub 2017 Nov 21.
    Institute of Health Economics and Technology Assessment, Vaclavska 316/12, 12000, Prague 2, Czech Republic.
    Background: Clinical trials and observational studies lacking measures of health-related quality of life (QoL) are often inapplicable when conducting cost-effectiveness analyses using quality-adjusted life-years (QALYs). The only solution is to map QoL ex post from additionally collected clinical outcomes and generic QoL instruments. Nonetheless, mapping studies are absent in psoriatic arthritis (PsA). Read More

    Acute Septic Arthritis of the Knee Caused by Kingella kingae in a 5-Year-Old Cameroonian Boy.
    Front Pediatr 2017 6;5:230. Epub 2017 Nov 6.
    Research Unit on Infectious and Emerging Tropical Diseases (URMITE), UM63, CNRS 7278, IRD 198, INSERM 1095, Aix-Marseille Université, IHU Méditerranée Infection, Marseille, France.
    Kingella kingae is an important cause of invasive infections in young children from Western countries. Although increasing reports indicate that this organism is the leading agent of bone and joint infections in early childhood, data on K. kingae infections from resource-limited settings are scarce, and none has yet been reported in Africa. Read More

    Tethering Interleukin-22 to Apolipoprotein A-I Ameliorates Mice from Acetaminophen-induced Liver Injury.
    Theranostics 2017 26;7(17):4135-4148. Epub 2017 Sep 26.
    Department of Microbiological and Biochemical Pharmacy & The Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P. R. China.
    Increasing evidence indicates that interleukin-22 (IL-22) holds tremendous potential as a protective agent in preventing liver injury, but its pleiotropic effects and pathogenic role in carcinogenesis, rheumatoid arthritis and psoriasis restrict its systemic application. Here, we first developed a nanoparticle (liposIA) as a liver-targeted agent through IL-22 tethered to apolipoprotein A-I (ApoA-I) in a gene therapy vector. LiposIA was prepared using thin film dispersion method and the complexes exhibited desirable nanoparticle size, fine polydisperse index, highly efficient transfection, and excellent serum and storage stability. Read More

    The combination of IL-6 and its soluble receptor is associated with the response of rheumatoid arthritis patients to tocilizumab.
    Semin Arthritis Rheum 2017 Nov 17. Epub 2017 Nov 17.
    Department of Immunology, Institut de Recerca, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain. Electronic address:
    Background: IL-6 contributes significantly to the chronic inflammatory process of rheumatoid arthritis (RA). Tocilizumab, a humanized anti-human IL-6 receptor antibody that blocks the signaling originated by the IL-6/IL-6R complex, is an effective treatment. However, predictors of the response to tocilizumab are still required. Read More

    90K immunostimulatory glycoprotein in children with juvenile idiopathic arthritis.
    Mod Rheumatol 2017 Nov 20:1-5. Epub 2017 Nov 20.
    a Department of Pediatrics , University of Chieti , Chieti , Italy.
    Objectives: To assess whether circulating levels of 90K glycoprotein are increased in children with juvenile idiopathic arthritis (JIA) at different stages of the disease, compared to healthy controls and to evaluate potential over time changes in its concentrations following treatment with the antitumor-necrosis factor (TNF) drug etanercept.

    Methods: 90K glycoprotein, C-reactive protein, erythrocyte sedimentation rate, TNF, antinuclear antibodies, rheumatoid factor and the Juvenile Arthritis Disease Activity Score were assessed in 71 children: 23 with newly diagnosed JIA, 23 with established and active JIA and 25 healthy controls. Patients, eligible for anti-TNF treatment, underwent a similar clinical/laboratory assessment after 6- and 12-month etanercept therapy. Read More

    Concordance and correlation of activity indices in patients with rheumatoid arthritis in northwestern Colombia: A cross-sectional study.
    Int J Rheum Dis 2017 Nov 19. Epub 2017 Nov 19.
    Immunology and Clinical Rheumatology Unit (UNIR) Group, School of Health Sciences, Clínica Universitaria Bolivariana, Universidad Pontificia Bolivariana, Medellín, Colombia.
    Aim: To determine the correlation and concordance between different clinimetric scores in patients with rheumatoid arthritis in two high-complexity reference centers in northwestern Colombia.

    Method: A cross-sectional study in adults diagnosed with rheumatoid arthritis was conducted according to the 2010 American College of Rheumatology and European League Against Rheumatism Classification Criteria, between January and June, 2013. The correlation was evaluated using Spearman's correlation coefficient, and concordance with quadratic weighted kappa with the respective confidence intervals, for which patients were classified into different categories of disease activity. Read More

    Nur77 Is Upregulated in B-1a Cells by Chronic Self-Antigen Stimulation and Limits Generation of Natural IgM Plasma Cells.
    Immunohorizons 2017 Nov;1(9):188-197
    Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143.
    B-1a cells are a unique population of innate-like B cells with a highly restricted and self-reactive BCR repertoire. Preimmune "natural" IgM produced by B-1a-derived plasma cells is essential for homeostatic clearance of cellular debris and forms a primary layer of protection against infection. In this study, we take advantage of a fluorescent reporter of BCR signaling to show that expression of the orphan nuclear hormone receptor Nur77 is upregulated under steady-state conditions in self-reactive B-1a cells in response to chronic Ag stimulation. Read More

    The expression of mRNA for peptidylarginine deiminase type 2 and type 4 in bone marrow CD34+ cells in rheumatoid arthritis.
    Clin Exp Rheumatol 2017 Nov 14. Epub 2017 Nov 14.
    Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
    Objectives: Antibodies directed to citrullinated proteins are highly specific for rheumatoid arthritis (RA). Citrullination is catalyzed by peptidylarginine deiminase (PAD) enzymes. The current study examined the mRNA expression of PADI2 and PADI4 in bone marrow (BM) CD34+ cells from RA patients. Read More

    Testing treat-to-target outcomes with initial methotrexate monotherapy compared with initial tumour necrosis factor inhibitor (adalimumab) plus methotrexate in early rheumatoid arthritis.
    Ann Rheum Dis 2017 Nov 16. Epub 2017 Nov 16.
    Medical University of Vienna and Hietzing Hospital, Ludwigshafen, Vienna, Austria.
    Objectives: To compare responses in patients with early rheumatoid arthritis (RA) initially treated with the tumour necrosis factor inhibitor (TNFi) adalimumab+methotrexate (MTX) versus MTX monotherapy who may have continued receiving MTX or switched to adalimumab rescue therapy after inadequate response to MTX.

    Methods: OPTIMA enrolled MTX-naive patients with active RA for <1 year. This post hoc analysis determined the proportion of patients, stratified by initial treatment, who achieved28-joint modified Disease Activity Score based on C reactive protein <3. Read More

    'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age.
    Mech Ageing Dev 2017 Nov 14. Epub 2017 Nov 14.
    Institute for Cell and Molecular Biosciences (ICaMB), Ageing Research Laboratories, Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne, NE4 5PL,United Kingdom; MRC/Arthritis Research UK Centre for Musculoskeletal Ageing (CIMA), United Kingdom. Electronic address:
    The ability of reactive oxygen species (ROS) to cause molecular damage has meant that chronic oxidative stress has been mostly studied from the point of view of being a source of toxicity to the cell. However, the known duality of ROS molecules as both damaging agents and cellular redox signals implies another perspective in the study of sustained oxidative stress. This is a perspective of studying oxidative stress as a constitutive signal within the cell. Read More

    TNF Antagonists: Killing Two "Birds" with one Biologic "Stone".
    Arthritis Rheumatol 2017 Nov 16. Epub 2017 Nov 16.
    Division of Rheumatology, Department of Medicine of the Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
    Forty years have passed since it was first recognized that patients with autoimmune rheumatic disease have an increased risk of fatal and non-fatal cardiovascular (CV) events (1) Although initial reports focused on rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), similar findings were verified subsequently in patients with psoriasis (Ps) and/or psoriatic arthritis (PsA) and spondyloarthritis. An early feature of the atherosclerotic lesion is infiltration with inflammatory cells, particularly monocytes/macrophages, and the presence of these cells in mature plaque elevates the risk of plaque rupture and thrombosis (2). In the general population, modest elevations of circulating inflammatory proteins, including C-reactive protein (CRP), interleukin-6 (IL-6) and soluble endothelial adhesion proteins, are associated with an increased risk of acute CV events (3). Read More

    DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation.
    Nat Commun 2017 Nov 15;8(1):1519. Epub 2017 Nov 15.
    Department of Immunology and Physiology, School of Medicine, Konkuk University, Chungju, 380-701, Republic of Korea.
    Receptor activator of NF-kB ligand (RANKL) generates intracellular reactive oxygen species (ROS), which increase RANKL-mediated signaling in osteoclast (OC) precursor bone marrow macrophages (BMMs). Here we show that a ROS scavenging protein DJ-1 negatively regulates RANKL-driven OC differentiation, also called osteoclastogenesis. DJ-1 ablation in mice leads to a decreased bone volume and an increase in OC numbers. Read More

    The Sex Influence on Response to Tumor Necrosis Factor-α Inhibitors and Remission in Axial Spondyloarthritis.
    J Rheumatol 2017 Nov 15. Epub 2017 Nov 15.
    From the Dipartimento di Medicina e Scienze della Salute "Vincenzo Tiberio," Università degli Studi del Molise, Campobasso; Day Hospital of Rheumatology, Azienda Sistema Socio Sanitario (ASST) Centro Specialistico Ortopedico Traumatologico G. Pini-Centro Specialistico Traumatologico-Ortopedico (CTO), Milan; Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Matera; La Struttura Semplice Dipartimentale (SSD) di Medicina e Reumatologia, Istituto Ortopedico Rizzoli, Università di Bologna, Bologna; Rheumatology Unit, Department of Clinical and Experimental Medicine (DIMED), University of Padua, Padua; Rheumatology Unit, Azienda Ospedaliera-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) di Reggio Emilia and Università di Modena e Reggio Emilia, Reggio Emilia, Italy. Supported by the Gruppo di Studio Spondiloartriti e Artropatia Psoriasica - Antonio Spadaro. All authors are members of this group. E. Lubrano, MD, PhD, Dipartimento di Medicina e Scienze della Salute "Vincenzo Tiberio," Università degli Studi del Molise; F.M. Perrotta, MD, Dipartimento di Medicina e Scienze della Salute "Vincenzo Tiberio," Università degli Studi del Molise; M. Manara, MD, PhD, Day Hospital of Rheumatology, ASST Centro Specialistico Ortopedico Traumatologico G. Pini-CTO; S. D'Angelo, MD, PhD, Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera; O. Addimanda, MD, PhD, SSD di Medicina e Reumatologia, Istituto Ortopedico Rizzoli, Università di Bologna; R. Ramonda, MD, PhD, Rheumatology Unit, DIMED, University of Padua; L. Punzi, MD, PhD, Rheumatology Unit, DIMED, University of Padua; I. Olivieri, MD, Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera; C. Salvarani, MD, IRCCS di Reggio Emilia and Università di Modena e Reggio Emilia; A. Marchesoni, MD, PhD, Day Hospital of Rheumatology, ASST Centro Specialistico Ortopedico Traumatologico G. Pini-CTO. Dr. Ignazio Olivieri died July 28, 2017. Address correspondence to Dr. E. Lubrano, Dipartimento di Medicina e di Scienze della Salute "Vincenzo Tiberio," Università degli Studi del Molise, Via Giovanni Paolo II, C/da Tappino, 86100 Campobasso, Italy. E-mail: Accepted for publication September 12, 2017.
    Objective: The aim of this study was to evaluate the influence of sex on response to treatment and disease remission in patients with axial spondyloarthritis (axSpA).

    Methods: In this retrospective multicenter study, patients with axSpA, according to the Assessment of Spondyloarthritis international Society (ASAS) criteria for axSpA, and treated with adalimumab, etanercept, golimumab, or infliximab, were studied. We compared clinical characteristics, patient-reported outcomes, disease activity, function, and response to treatment in male and female patients with this disease. Read More

    [Tocilizumab for refractory systemic juvenile idiopathic arthritis].
    Zhonghua Er Ke Za Zhi 2017 Nov;55(11):830-834
    Department of Rheumatism and Immunology, Children's Hospital Affiliated to Capital Institute of Pediatrics, Beijing 100020, China.
    Objective: To evaluate the efficacy and side effects of tocilizumab for the treatment of systemic juvenile idiopathic arthritis. Method: In this prospective self case-control study, the children diagnosed with refractory systemic juvenile idiopathic arthritis admitted to Department of Rheumatism and Immunology of Children's Hospital Affiliated to Capital Institute of Pediatrics from December 2013 to June 2016 were enrolled and information before and after treatment of tocilizumab was analyzed. The tocilizumab was introvenously guttae in a dose of 8-12 mg/kg every 2 weeks. Read More

    Potential risk factors for reactive arthritis and persistence of symptoms at 2 years: a case-control study with longitudinal follow-up.
    Clin Rheumatol 2017 Nov 14. Epub 2017 Nov 14.
    Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
    The objective of the study is to determine the risk factors for the development of reactive arthritis (ReA) and examine the factors associated with the persistence of symptoms. Patients with a new diagnosis of ReA and controls with a gastrointestinal (GI), urogenital, or sexually transmitted infection in the 3-6 months prior to study entry were prospectively enrolled in Guatemala City. ReA patients fulfilled the Assessment in Spondyloarthritis International Society criteria for peripheral spondyloarthropathy (SpA). Read More

    [The 459th case: arthralgia, fever, rash, and thrombocytopenia].
    Zhonghua Nei Ke Za Zhi 2017 Nov;56(11):894-896
    Department of Hematology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
    The differential diagnoses of reactive arthritis presenting as arthralgia should be considered as diverse disorders, especially when the symptoms cannot be fully explained by some definite diseases. Do not ignore the indication of bone marrow aspiration. We reported a 50-year-old woman who complained of arthralgia, recurrent fever and rash 9 months ago. Read More

    HLA-B27 Correlates with the Intracellular Elimination, Replication, and Trafficking of Salmonella Enteritidis Collected from Reactive Arthritis Patients.
    Med Sci Monit 2017 Nov 14;23:5420-5429. Epub 2017 Nov 14.
    Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan, China (mainland).
    BACKGROUND The aim of this study was to explore the correlation between HLA-B27 and the intracellular elimination, replication, and trafficking of Salmonella enteritidis (S. enteritidis) collected from patients with reactive arthritis. MATERIAL AND METHODS Confocal microscopy, flow cytometry, and sandwich enzyme-linked immunosorbent assay (ELISA) were employed in this study to evaluate the localization of proteins of interest, to assess the intracellular trafficking of S. Read More

    IRAK2 is associated with susceptibility to rheumatoid arthritis.
    Clin Rheumatol 2017 Nov 11. Epub 2017 Nov 11.
    Laboratory of Immunology, Research Unit UR 807, Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia.
    This study was performed to investigate the association of the single nucleotide polymorphisms of interleukin-1 receptor-associated kinase 2 (IRAK2) rs3844283 and rs708035 with rheumatoid arthritis (RA). IRAK2 rs3844283 and rs708035genotyping was determined by mutagenically separated PCR with specifically designed primers in a cohort of 222 (30 men, 192 women, mean age 49 years) adult RA patients and 224 matched controls. IRAK2 rs3844283 C allele was detected in 66% of RA patients and 74% of controls. Read More

    Cutting Edge: Processing of Oxidized Peptides in Macrophages Regulates T Cell Activation and Development of Autoimmune Arthritis.
    J Immunol 2017 Nov 10. Epub 2017 Nov 10.
    Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Stockholm, Sweden;
    APCs are known to produce NADPH oxidase (NOX) 2-derived reactive oxygen species; however, whether and how NOX2-mediated oxidation affects redox-sensitive immunogenic peptides remains elusive. In this study, we investigated a major immunogenic peptide in glucose-6-phosphate isomerase (G6PI), a potential autoantigen in rheumatoid arthritis, which can form internal disulfide bonds. Ag presentation assays showed that presentation of this G6PI peptide was more efficient in NOX2-deficient (Ncf1(m1J/m1J) mutant) mice, compared with wild-type controls. Read More

    Drugs Implicated in Systemic Autoimmunity Modulate Neutrophil Extracellular Trap Formation.
    Arthritis Rheumatol 2017 Nov 9. Epub 2017 Nov 9.
    Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
    Objective: Aberrant neutrophil extracellular trap (NET) formation has been implicated as a mechanism to induce auto-reactivity in at-risk individuals. The study objective was to assess whether medications implicated in cases of drug-induced autoimmunity (hydralazine and procainamide) and medications less commonly associated with drug-induced autoimmunity (minocycline and clozapine) induce NET formation and/or prevent NET degradation.

    Methods: Human neutrophils were incubated with the drugs of interest and resultant NET formation was quantified by fluorescent microscopy. Read More

    Elderly Patients Exhibit Stronger Inflammatory Responses during Gout Attacks.
    J Korean Med Sci 2017 Dec;32(12):1967-1973
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
    Gout attacks are often accompanied by systemic inflammatory response. The aim of the retrospective study was to compare gout patients in different age groups in terms of their clinical features at gout attacks. Patients, who were treated for gout attack in two tertiary medical centers between January 2000 and April 2014, were divided into young (≤ 50 years), middle-aged, and elderly (> 65 years) groups. Read More

    Reply to Bigler et al. (ar-17-1461).
    Arthritis Rheumatol 2017 Nov 6. Epub 2017 Nov 6.
    University of Alabama at Birmingham, Birmingham, AL.
    We thank Dr. Bigler and his colleagues for their interest in our article and sharing the results from their laboratory. The authors proposed evaluating a biologic mechanism linking Varicella Zoster Virus (VZV) to giant cell arteritis (GCA) through assessment of cross-reactive VZV-specific T cell immunity, hypothesizing that VZV reactive T-cells would be increased in GCA patients relative to controls. Read More

    Acute effect of a resistance exercise session on markers of cartilage breakdown and inflammation in women with rheumatoid arthritis.
    Int J Rheum Dis 2017 Nov 3. Epub 2017 Nov 3.
    Department of Human Movement Sciences, Universidade Federal de São Paulo, São Paulo, Brazil.
    Aim: To assess the acute effect of resistance exercise (RE) on circulating biomarkers of cartilage breakdown and inflammation in women with rheumatoid arthritis (RA).

    Methods: Thirty-four volunteers (17 with and 17 without RA), participated in a 25 min RE session (knee extension, knee flexion, hip abduction and hip adduction) with one set of 12 repetitions at 50% of one repetition maximum (1RM) and one set of eight repetitions at 75% of 1RM. Blood samples were collected 30 and 5 min before, immediately after and 1, 2 and 24 h after the session. Read More

    Annonaceae: Breaking the Wall of Inflammation.
    Front Pharmacol 2017 20;8:752. Epub 2017 Oct 20.
    Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
    Inventories of tropical forests have listed Annonaceae as one of the most diverse plant families. For centuries, it is employed in traditional medicines to cure various pathological conditions including snakebite, analgesic, astringent, diarrhea, dysentery, arthritis pain, rheumatism, neuralgia, and weight loss etc. Phytochemical analysis of Annonaceae family have reported the occurrence of alkaloids, flavonoids, triterpenes, diterpenes and diterpene flavone glycosides, sterols, lignans, and annonaceous acetogenin characteristically affiliated with Annonaceae sp. Read More

    Increased levels of interleukin-22 in thoracic aorta and plasma from patients with acute thoracic aortic dissection.
    Clin Chim Acta 2017 Nov 3. Epub 2017 Nov 3.
    Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, China. Electronic address:
    Background: Interleukin (IL)-22 plays important roles in the development of arterial disease, including atherosclerosis and hypertension. However, the relationship between IL-22 and acute thoracic aortic dissection (TAD) remains unknown.

    Methods: Blood samples were collected from patients with chest pain who underwent computed tomography angiography of the thoracic aorta but had no known preoperative diagnosis of coronary artery disease, peripheral artery disease, arthritis, and/or membranous nephropathy. Read More

    Red blood cell distribution width: a potential laboratory parameter for monitoring inflammation in rheumatoid arthritis.
    Clin Rheumatol 2017 Nov 3. Epub 2017 Nov 3.
    First Clinical College, Fujian Medical University, Fuzhou, China.
    Correlation analysis of red blood cell distribution width (RDW) and C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), tumor necrosis factor α (TNF-α), interleukin (IL)-6, and IL-10 in rheumatoid arthritis (RA) to investigate whether RDW can serve as a potential parameter for indicating inflammation in RA patients. A total of 670 RA patients from October 2014 to April 2016 were enrolled in our study. The white blood cell (WBC), red blood cell (RBC), platelet (PLT), hemoglobin (HGB), RDW, CRP, and ESR in peripheral blood of patients with RA were retrospectively analyzed. Read More

    [Effect of Sanbitang recipe in treatment of rheumatoid arthritis with kidney empty and cold-dampness symptom].
    Zhongguo Zhong Yao Za Zhi 2017 Jul;42(14):2802-2807
    The Chinese Medicine Hospital of Henan, Zhengzhou 450009, China.
    To explore the clinical effect of Sanbitang recipe in treatment for the rheumatoid arthritis (RA) with kidney empty and cold-dampness symptom and its safety. A total 168 cases eligible patients were randomly divided into the traditional Chinese medicine (TCM) group, the chemical medicine group and the TCM combined with chemical medicine group, with 56 cases in each group. The TCM group was treated with Sanbitang recipe; The chemical medicine group was given methotrexate tablets; And Sanbitang recipe and methotrexate tablets was adopted in the TCM combined with chemical medicine group. Read More

    Arthroscopic Management of Septic Arthritis of the Native Shoulder: A Systematic Review.
    Arthroscopy 2017 Oct 30. Epub 2017 Oct 30.
    Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada. Electronic address:
    Purpose: To investigate arthroscopic management of native shoulder joint septic arthritis-specifically, indications, patient outcomes, and complications.

    Methods: PubMed, MEDLINE, and Embase were used to search the literature, and data abstraction was performed independently and in duplicate. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist guided reporting and data abstraction. Read More

    A young female presenting with unilateral sacroiliitis following dengue virus infection: a case report.
    J Med Case Rep 2017 Nov 1;11(1):307. Epub 2017 Nov 1.
    National Hospital of Sri Lanka, Colombo, Sri Lanka.
    Background: Dengue is a common arthropod-borne viral infection in Sri Lanka which is spread by the mosquitos of the genus Aedes. The clinical features of dengue include high-grade fever associated with arthralgia and myalgia. However, dengue virus is not considered an arthritogenic virus. Read More

    Emerging Treatment Models in Rheumatology: IgG4-Related Disease: Insights Into Human Immunology and Targeted Therapies. Comments on the article by Perugino et al.
    Arthritis Rheumatol 2017 Oct 31. Epub 2017 Oct 31.
    department of Internal Medicine, section Clinical Immunology, Erasmus Medical Center, Rotterdam, The Netherlands.
    We read with great interest the published article by Perugino et al (1) providing an excellent overview on IgG4-related disease (IgG4-RD). However, the authors have not included the value of C-reactive protein (CRP) in IgG4-RD and the potential secondary complications due to this. Herewith, we want to highlight the clinical relevance of elevated CRP in IgG4-RD. Read More

    Predictors and long-term outcome in Greek adults with juvenile idiopathic arthritis: a 17-year continuous follow-up study.
    Rheumatology (Oxford) 2017 Nov;56(11):1928-1938
    4th Academic Department of Internal Medicine, Aristotle University.
    Objectives: To describe the disease characteristics, continuous course and long-term outcome and to evaluate predictors of outcome in JIA in Greece.

    Methods: We performed a retrospective cohort analysis of 17 years' prospective data on JIA. Outcome assessment included radiographic (modified Sharp-van der Heidje score), articular and extra-articular damage (Juvenile Arthritis Damage Index), functional ability (HAQ Disability Index), and the cumulative percentage time spent in a state of active disease and also in clinical remission off medication (CR) (according to Wallace's criteria). Read More

    Ideal target for psoriatic arthritis? Comparison of remission and low disease activity states in a real-life cohort.
    Ann Rheum Dis 2017 Oct 28. Epub 2017 Oct 28.
    Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
    Background: Psoriatic arthritis (PsA) recommendations state that the target of treatment should be remission or low disease activity (LDA). We used a real-life dataset to compare different potential targets.

    Methods: 250 patients with PsA considered in an acceptable disease state according to their rheumatologist were included. Read More

    Clinical and functional significance of STEAP4-splice variant in CD14(+) monocytes in patients with rheumatoid arthritis.
    Clin Exp Immunol 2017 Oct 28. Epub 2017 Oct 28.
    Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
    Tumour necrosis factor alpha (TNF)-α-induced adipose-related protein (TIARP) is a negative regulator of inflammation in arthritis model mice. In humans, six-transmembrane epithelial antigen of prostate 4 (STEAP4) (human counterpart of TIARP) is also expressed in CD14(+) monocytes from patients with rheumatoid arthritis (RA). Recently, highly levels of exon 3-spliced variant STEAP4 (v-STEAP4) expression have been observed in porcine lung. Read More

    Imaging of juvenile spondyloarthritis. Part I: Classifications and radiographs.
    J Ultrason 2017 Sep 29;17(70):167-175. Epub 2017 Sep 29.
    Radiology Department ,,St. Erasmo" Hospital for Orthopedic Surgery and Traumatology, Skopje, Macedonia.
    Juvenile spondyloarthropathies are manifested mainly by symptoms of peripheral arthritis and enthesitis. By contrast with adults, children rarely present with sacroiliitis and spondylitis. Imaging and laboratory tests allow early diagnosis and treatment. Read More

    Understanding the antibody repertoire in Neuropsychiatric Systemic Lupus Erythematosus and Neuromyelitis Optica Spectrum Disorders: do they share common targets?
    Arthritis Rheumatol 2017 Oct 26. Epub 2017 Oct 26.
    The Center of Autoimmune, Musculoskeletal and Hematopoietic Diseases The Feinstein Institute for Medical Research, Manhasset, NY.
    Objective: DWEYS-IgG cross-reactive with DNA and the N-methyl-D-aspartate receptor subunits GluN2A/GluN2B has been associated with neuropsychiatric systemic lupus erythematosus (NPSLE). DWEYS-IgG has not been investigated in demyelinating NPSLE (dNPSLE) or in another demyelinating disorder, Neuromyelitis Optica Spectrum Disorder (NMOSD), which is also a disease of young women and associated with aquaporin-4 (AQP4) or myelin oligodendrocyte glycoprotein (MOG) antibodies. We investigated the frequency of these brain-reactive antibodies in NPSLE, dNPSLE and NMOSD. Read More

    Gut Microbiota Perturbations in Reactive Arthritis and Post-Infectious Spondyloarthritis.
    Arthritis Rheumatol 2017 Oct 26. Epub 2017 Oct 26.
    Department of Medicine, Division of Rheumatology and Psoriatic Arthritis Center, New York University School of Medicine and Hospital for Joint Diseases, New York, NY.
    Objective: Reactive arthritis (ReA) is an inflammatory disorder occurring several weeks after gastrointestinal or genitourinary infections. HLA-B27 positivity is considered a risk factor, though not necessarily predictive of disease incidence. Among non-genetic factors, the intestinal microbiome may play a role in disease susceptibility. Read More

    [Effects of Electroacupuncture on Joint Function in Rheumatoid Arthritis Patients of Liver- and Kidney-Yin Deficiency Type].
    Zhen Ci Yan Jiu 2016 Oct;41(5):440-6
    Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China; Shanghai Research Institute of Acupuncture and Meridian, Shanghai 200030.
    Objective: To compare the effects between electroacupuncture (EA) plus western medicine and simple western medicine in improving clinical symptoms and local joint function of rheumatoid arthritis (RA) patients with yin deficiency of Liver and Kidney.

    Methods: A total of 68 RA patients of yin deficiency of Liver and Kidney were equally randomized into EA+medication group and medication group (n=34 in each group). Both groups were given once-a-week methotrexate (7. Read More

    Variants of genes implicated in type 1 interferon pathway and B-cell activation modulate the EULAR response to rituximab at 24 weeks in rheumatoid arthritis.
    RMD Open 2017 28;3(2):e000448. Epub 2017 Sep 28.
    Department of Rheumatology, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Université Paris Diderot, Paris, France.
    Background: The type 1 interferon (IFN) pathway has been identified to potentially affect the response to rituximab (RTX) for rheumatoid arthritis (RA), which suggests the contribution of type 1 IFN pathway genes such as IFN regulatory factor 5 and 7 (IRF5 and IRF7), tyrosine kinase 2 (TYK2), signal transducer and activator of transcription 4 (STAT4) and osteopontin (SPP1). Our objective was to study functional variants of these IFN pathway genes as predictors of the European League Against Rheumatism (EULAR) response to RTX for RA at week 24 (W24).

    Methods: Logistic regression analysis with a stepwise multivariate model adjusted for sex, age and DAS28-CRP (Disease Activity Score in 28 joints with C reactive protein) in 115 patients from the SMART randomised studywas used to analyse the association between the candidate variants and W24 EULAR response. Read More

    Affinity maturation shapes the function of agonistic antibodies to peptidylarginine deiminase type 4 in rheumatoid arthritis.
    Ann Rheum Dis 2017 Oct 25. Epub 2017 Oct 25.
    Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Objectives: The citrullinating enzyme peptidylarginine deiminase type 4 (PAD4) is the target of a polyclonal group of autoantibodies in patients with rheumatoid arthritis (RA). A subgroup of such antibodies, initially identified by cross-reactivity with peptidylarginine deiminase type 3 (PAD3), is strongly associated with progression of radiographic joint damage and interstitial lung disease and has the unique ability to activate PAD4. The features of these antibodies in terms of their T cell-dependent origin, genetic characteristics and effect of individual antibody specificities on PAD4 function remain to be defined. Read More

    Thyroid disorders in patients with newly diagnosed rheumatoid arthritis is associated with poor initial treatment response evaluated by disease activity score in 28 joints-C-reactive protein (DAS28-CRP): An observational cohort study.
    Medicine (Baltimore) 2017 Oct;96(43):e8357
    aDepartment of Rheumatology, Odense University Hospital, Svendborg Hospital, Svendborg bFaculty of Health Sciences, University of Southern Denmark, Odense cDepartment of Endocrinology, Odense University Hospital, Svendborg Hospital, Svendborg dDANBIO Registry, Copenhagen, Denmark.
    To determine the prevalence of thyroid disorders among newly diagnosed rheumatoid arthritis (RA) patients and evaluate the association between clinical characteristics of RA and thyroid disorders, and also initial treatment response in the RA patients with thyroid disorders.Newly diagnosed, adult RA patients who were diagnosed according to the new 2010 American College of Rheumatology/European League Against Rheumatism criteria since January 1, 2010, were included. Patients' demographic data, serology results including immunoglobulin M rheumatoid factor (IgM RF), anticyclic citrullinated peptide antibody (anti-CCP), and antinuclear antibody (ANA), and also disease activity score in 28 joints-C-reactive protein at the time of diagnosis and after 4 months (±1-2 months) of treatment initiation were extracted from Danish Danbio Registry. Read More

    Relevance of structural damage in the sacroiliac joints for the functional status and spinal mobility in patients with axial spondyloarthritis: results from the German Spondyloarthritis Inception Cohort.
    Arthritis Res Ther 2017 Oct 24;19(1):240. Epub 2017 Oct 24.
    Department of Gastroenterology, Infectiology and Rheumatology, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.
    Background: Functional status and spinal mobility in patients with axial spondyloarthritis (axSpA) are known to be determined both by disease activity and by structural damage in the spine. The impact of structural damage in the sacroiliac joints (SIJ) on physical function and spinal mobility in axSpA has not been studied so far. The objective of the study was to analyze the impact of radiographic sacroiliitis on functional status and spinal mobility in patients with axSpA. Read More

    Seroprevalence of Toxoplasma gondii infection in arthritis patients in eastern China.
    Infect Dis Poverty 2017 Oct 25;6(1):153. Epub 2017 Oct 25.
    State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province, 730046, People's Republic of China.
    Background: There is accumulating evidence for an increased susceptibility to infection in patients with arthritis. We sought to understand the epidemiology of Toxoplasma gondii infection in arthritis patients in eastern China, given the paucity of data on the magnitude of T. gondii infection in these patients. Read More

    Changes in clinical disease activity are weakly linked to changes in MRI inflammation on treat-to-target escalation of therapy in rheumatoid arthritis.
    Arthritis Res Ther 2017 Oct 24;19(1):241. Epub 2017 Oct 24.
    Department of Radiology, Auckland City Hospital, 2 Park Rd, Grafton, Auckland, 1023, New Zealand.
    Background: Rheumatoid arthritis (RA) treat-to-target (T2T) regimens often use the disease activity score (28 joints) incorporating C-reactive protein (DAS28CRP) as an outcome measure. We compared changes in the DAS28CRP with changes in magnetic resonance imaging (MRI) inflammation on treatment escalation.

    Methods: Eighty seropositive RA patients with active disease were enrolled. Read More

    Dimethyl fumarate inhibits osteoclasts via attenuation of reactive oxygen species signalling by augmented antioxidation.
    J Cell Mol Med 2017 Oct 24. Epub 2017 Oct 24.
    Department of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama, Japan.
    Bone destructive diseases are common worldwide and are caused by dysregulation of osteoclast formation and activation. During osteoclastogenesis, reactive oxygen species (ROS) play a role in the intracellular signalling triggered by receptor activator of nuclear factor-κB ligand (RANKL) stimulation. Previously, we demonstrated that induction of antioxidant enzymes by Nrf2 activation using Nrf2-gene transfer, an ETGE-peptide or polyphenols, successfully ameliorated RANKL-dependent osteoclastogenesis. Read More

    Morbid Sequences Suggest Molecular Mimicry between Microbial Peptides and Self-Antigens: A Possibility of Inciting Autoimmunity.
    Front Microbiol 2017 9;8:1938. Epub 2017 Oct 9.
    Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India.
    Understanding etiology of autoimmune diseases has been a great challenge for designing drugs and vaccines. The pathophysiology of many autoimmune diseases may be attributed to molecular mimicry provoked by microbes. Molecular mimicry hypothesizes that a sequence homology between foreign and self-peptides leads to cross-activation of autoreactive T cells. Read More

    JTE-852, a novel spleen tyrosine kinase inhibitor, blocks immunoglobulin G-mediated cellular responses and autoimmune reactions in vivo.
    Life Sci 2017 Dec 19;191:166-174. Epub 2017 Oct 19.
    Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., Osaka, Japan.
    Aims: Immune and inflammatory responses mediated by immunoglobulin (Ig) G are largely responsible for the pathogenesis of autoimmune diseases. Spleen tyrosine kinase (Syk) plays a pivotal role in the IgG-mediated responses; therefore, Syk has emerged as a new therapeutic target for the treatment of autoimmune diseases. In this study, we investigated the inhibitory actions of JTE-852, a novel Syk inhibitor, on IgG-mediated cellular responses and autoimmune reactions in vivo. Read More

    The serum level and significance of lysyl oxidase-like 2 in patients with rheumatoid arthritis-associated interstitial lung disease.
    Clin Rheumatol 2017 Oct 19. Epub 2017 Oct 19.
    Department of Rheumatology and Immunology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gong-Ti South Road, Chaoyang District, 100020, Beijing, People's Republic of China.
    Our previous experiments found that lysyl oxidase-like 2 (LOXL2) may be a useful preclinical serological marker for pulmonary fibrosis in the mouse model. The role of LOXL2 in rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is still unclear. We investigated whether serum LOXL2 levels are associated with RA-ILD patients. Read More

    Increased circulating Th22 cells in patients with acute gouty arthritis: A CONSORT-compliant article.
    Medicine (Baltimore) 2017 Oct;96(42):e8329
    aDepartment of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College bTranslational Medicine Research Center, North Sichuan Medical College, Nanchong, Sichuan, P.R. China.
    Background: T-helper 22 (Th22) cells are involved in host immunity against pathogen invasion and have been implicated in the pathogenesis of inflammatory diseases. However, the roles of Th22 cells in acute gouty arthritis remain unclear.

    Methods: A case-control study was employed to illustrate the clinical significance of Th22 cells in acute gouty arthritis. Read More

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