15,061 results match your criteria Reactive Arthritis


The changing profile of ankylosing spondylitis in the biologic era.

Clin Rheumatol 2020 Jul 9. Epub 2020 Jul 9.

Division of Rheumatology, Cedars Sinai Medical Center Los Angeles, Los Angeles, CA, USA.

Objective: To compare disease characteristics, comorbidities, and medication utilization of 1141 patients with ankylosing spondylitis (AS) with short (< 20 years) and long (≥ 20 years) disease duration enrolled in the Prospective Study of Outcomes in AS (PSOAS) study over three different periods of time and followed longitudinally.

Methods: Study visits were carried out every 6 months examining disease activity (Bath AS Disease Activity Index (BASDAI), C-reactive protein, erythrocyte sedimentation rate), functional impairment, depression, and medication utilization as well as radiographic severity. Groups were compared with regression models using generalized estimating equation, linear, and Poisson regressions after adjusting for sites and for patients withdrawing from the study at less than 2 years follow-up. Read More

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http://dx.doi.org/10.1007/s10067-020-05260-8DOI Listing

Parenting problems postpartum can be detected early in pregnancy in patients with rheumatoid arthritis.

RMD Open 2020 Jul;6(2)

Rheumatology, Erasmus MC, Rotterdam, Netherlands.

Objective: To describe parenting disability postpartum in patients with rheumatoid arthritis (RA) using the Parenting Disability Index and to determine early in pregnancy which patients will face parenting problems postpartum.

Methods: Data were collected from a prospective study on pregnancy and RA (Pregnancy induced Amelioration of Rheumatoid Arthritis study). Postpartum visits were performed at 6, 12 and 26 weeks after delivery. Read More

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http://dx.doi.org/10.1136/rmdopen-2020-001276DOI Listing

Baricitinib, a drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19.

Int Immunopharmacol 2020 Jul 1;86:106749. Epub 2020 Jul 1.

Department of Pharmacy, Wuxi People's Hospital Attached to Nanjing Medical University, Wuxi 214023, Jiangsu, China. Electronic address:

In December 2019, a novel coronavirus pneumonia (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suddenly broke out in China and rapidly spread all over the world. Recently, a cell surface protein, known as angiotensin-converting enzyme II (ACE2), has been identified to be involved in receptor-mediated endocytosis for SARS-CoV-2 entry to the cells. Many studies have reported the clinical characteristics of COVID-19: sudden deterioration of disease around 1-2 weeks after onset; much lower level of lymphocytes, especially natural killer (NK) cells in peripheral blood; extremely high pro-inflammatory cytokines and C reactive protein (CRP). Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106749DOI Listing

In vivo synthesis of bacterial amyloid curli contributes to joint inflammation during S. Typhimurium infection.

PLoS Pathog 2020 Jul 9;16(7):e1008591. Epub 2020 Jul 9.

Department of Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, United States of America.

Reactive arthritis, an autoimmune disorder, occurs following gastrointestinal infection with invasive enteric pathogens, such as Salmonella enterica. Curli, an extracellular, bacterial amyloid with cross beta-sheet structure can trigger inflammatory responses by stimulating pattern recognition receptors. Here we show that S. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008591DOI Listing

Epidemiological and clinical characteristics of bacteremic brucellosis.

J Int Med Res 2020 Jul;48(7):300060520936829

Department of Infectious Diseases, Tianjin Second People's Hospital, Tianjin, China.

Objective: To retrospectively investigate the epidemiological features, clinical manifestations and laboratory characteristics of bacteremic brucellosis.

Methods: Brucellosis patients admitted to our clinic from January 2015 to December 2017 were included in the study. Patient electronic medical records were reviewed for epidemiological features, clinical manifestations, and laboratory findings. Read More

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http://dx.doi.org/10.1177/0300060520936829DOI Listing

Antibodies against three novel peptides in early axial spondyloarthritis patients from two independent cohorts.

Arthritis Rheumatol 2020 Jul 8. Epub 2020 Jul 8.

Hasselt University, Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life Sciences, Hasselt, Belgium.

Objective: The aim of this study was to identify novel autoantibodies in axial spondyloarthritis (axSpA) and determine their diagnostic potential in early axSpA patients and controls from two independent cohorts.

Methods: An axSpA cDNA phage display library was used to screen for novel immunoglobulin G (IgG) antibodies in plasma of early axSpA patients. Presence of these antibodies against novel Hasselt University (UH)-axSpA peptides was determined in 76 early axSpA patients, 75 non-specific chronic low back pain (CLBP) controls, 60 rheumatoid arthritis (RA) patients and 94 healthy controls (HC) from the UH cohort using enzyme-linked immunosorbent assays (ELISA). Read More

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http://dx.doi.org/10.1002/art.41427DOI Listing

Efficacy and Safety of Upadacitinib Monotherapy in Methotrexate-naïve Patients with Moderately to Severely Active Rheumatoid Arthritis (SELECT-EARLY): A Randomized, Double-blind, Active-comparator, Multi-center, Multi-country Trial.

Arthritis Rheumatol 2020 Jul 8. Epub 2020 Jul 8.

Stanford University, Palo Alto, CA, USA.

Objective: The SELECT-EARLY trial studied the effect of upadacitinib, an oral, reversible, JAK inhibitor, as monotherapy in patients with predominantly early rheumatoid arthritis who are naïve or have limited exposure to methotrexate.

Methods: Patients were randomized (n=947, 1:1:1) to once-daily upadacitinib (15mg or 30mg) or weekly methotrexate (7.5-20mg/week) for 24 weeks. Read More

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http://dx.doi.org/10.1002/art.41384DOI Listing

Comparative analysis of synovial inflammation after SARS-CoV-2 infection.

Ann Rheum Dis 2020 Jul 6. Epub 2020 Jul 6.

Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia, Roma, Italy

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http://dx.doi.org/10.1136/annrheumdis-2020-218315DOI Listing

Intra-articular injection of etanercept versus glucocorticoids in rheumatoid arthritis patients.

Clin Rheumatol 2020 Jul 4. Epub 2020 Jul 4.

Physical Medicine, Rheumatology, and Rehabilitation Department, Faculty of Medicine, Tanta University, Geish Street, Tanta, Gharbia, Egypt.

Objectives: This study was conducted to assess the safety and efficacy of intra-articular injection of etanercept and compare it with corticosteroid injection in rheumatoid arthritis (RA) patients.

Methods: Fifty patients with RA who suffered from activity in one joint were randomized into two groups, received an intra-articular injection of either etanercept or corticosteroid guided by musculoskeletal ultrasound. All patients were assessed for disease activity by disease activity score (DAS28), functional assessment using the Modified Health Assessment Questionnaire (MHAQ), and laboratory investigations (erythrocyte sedimentation rate and C-reactive protein). Read More

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http://dx.doi.org/10.1007/s10067-020-05235-9DOI Listing

Comprehensive arginine metabolomics and peripheral vasodilatory capacity in rheumatoid arthritis: A monocentric cross-sectional study.

Microvasc Res 2020 Jul 2:104038. Epub 2020 Jul 2.

Departiment of Biomedical Sciences, University of Sassari, Sassari, Italy.

Background: The relationship between plasma arginine metabolites influencing vascular homeostasis and peripheral vasodilatory capacity in rheumatoid arthritis (RA) patients is not known.

Methods: l-arginine (Arg), monomethyl-l-arginine (MMA), l-homoarginine (hArg), asymmetric dimethyl-l-arginine (ADMA), symmetric dimethyl-l-arginine, and l-citrulline (Cit) were measured by liquid chromatography tandem mass spectrometry (LC-MS/MS) in 164 RA patients and 100 age- and sex-matched healthy controls without previous cardiovascular events. Log-transformed reactive hyperemia index (Ln-RHI) evaluated by flow-mediated pulse amplitude tonometry (PAT, EndoPAT2000 device) was assessed as surrogate measure of peripheral vasodilatory capacity in RA patients. Read More

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http://dx.doi.org/10.1016/j.mvr.2020.104038DOI Listing

Cutaneous manifestation of reactive arthritis.

Joint Bone Spine 2020 Jul 1. Epub 2020 Jul 1.

Department of dermatology, Besançon University hospital, Besançon, France. Electronic address:

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http://dx.doi.org/10.1016/j.jbspin.2020.06.010DOI Listing

Sustained cutaneous remission with adalimumab in reactive arthritis: a case series.

Dermatol Ther 2020 Jul 4:e13965. Epub 2020 Jul 4.

Department of Dermatology, Rajiv Gandhi Medical College and Chhatrapati Shivaji Maharaj Hospital,, Kalwa, India.

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http://dx.doi.org/10.1111/dth.13965DOI Listing

Role of Nrf2 in rheumatoid arthritis.

Curr Res Transl Med 2020 Jul 1. Epub 2020 Jul 1.

Chitkara College of Pharmacy, Chitkara University, Punjab, India.

Background: Rheumatoid arthritis comprises the roots of 19th century and is an autoimmune and chronic inflammatory disorder leading to progressive joint destruction. This erosive joint damage is linked with infiltration of leukocytes along with inflammatory destruction and blood cell formation within the synovial membrane, deprivation of cartilage and bone that leads to incapacitative pain. The changes in synovium include its proliferation that leads to pannus formation and this ultimately leads to the invasion and erosions causing the destruction of joints. Read More

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http://dx.doi.org/10.1016/j.retram.2020.05.002DOI Listing

Decreased levels of interleukin 27 in the serum of vitiligo patients.

An Bras Dermatol 2020 Jun 16. Epub 2020 Jun 16.

Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Background: Vitiligo is a common skin disorder in which melanocytes are destroyed by auto-reactive immune responses. The loss of melanocytes results in the appearance of depigmented areas in different parts of the body. Cytokines have remarkable roles in the pathogenesis of vitiligo, such as IL-1, IL-6, and TNF-α; interleukin 27 (IL-27) is a new member of the IL-6/IL-12 family, mainly released by activated antigen-presenting cells. Read More

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http://dx.doi.org/10.1016/j.abd.2020.02.005DOI Listing

Human Fcγ-receptor IIb modulates pathogen-specific versus self-reactive antibody responses in Lyme arthritis.

Elife 2020 Jul 2;9. Epub 2020 Jul 2.

Departemtn of Biology, Division of Genetics, University of Erlangen-Nuremberg, Erlangen, Germany.

Pathogen specific antibody responses need to be tightly regulated to generate protective but limit self-reactive immune responses. While loss of humoral tolerance has been associated with microbial infections, the pathways involved in balancing protective versus autoreactive antibody responses in humans are incompletely understood. Studies in classical mouse model systems have provided evidence that balancing of immune responses through inhibitory receptors is an important quality control checkpoint. Read More

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http://dx.doi.org/10.7554/eLife.55319DOI Listing

Two-Stage Primary Arthroplasty of Native Hips and Knees That Had Previously Failed Treatment for Septic Arthritis: A Single-Center Experience.

Arthroplast Today 2020 Sep 23;6(3):431-436. Epub 2020 Jun 23.

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA.

Background: Patients with a history of degenerative joint disease secondary to an acute or remote episode of septic arthritis of the native knee or hip present a unique challenge for the orthopaedic surgeon. This study describes our experience with two-stage primary arthroplasty for such patients.

Methods: We reviewed 42 patients with a history of septic arthritis treated with two-stage primary arthroplasty between 2008 and 2018. Read More

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http://dx.doi.org/10.1016/j.artd.2020.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316870PMC
September 2020

An imbalance between blood CD4CXCR5Foxp3 Tfr cells and CD4CXCR5Tfh cells may contribute to the immunopathogenesis of rheumatoid arthritis.

Mol Immunol 2020 Jun 27;125:1-8. Epub 2020 Jun 27.

Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, 750004, PR China. Electronic address:

Background: Follicular helper T (Tfh) cells are a subgroup of activated CD4 T cells which can assist the formation and maintenance of germinal centers. Follicular regulatory T (Tfr) cells are a new class of regulatory T cells which play a major role in suppressing cells in humoral immunity. In contrast to the role of Tfh cells, Tfr cells can inhibit the function of Tfh cells and B cells. Read More

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http://dx.doi.org/10.1016/j.molimm.2020.06.003DOI Listing

Neonatal Exposure to Commensal-Bacteria-Derived Antigens Directs Polysaccharide-Specific B-1 B Cell Repertoire Development.

Immunity 2020 Jun 23. Epub 2020 Jun 23.

Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address:

B-1 B cells derive from a developmental program distinct from that of conventional B cells, through B cell receptor (BCR)-dependent positive selection of fetally derived precursors. Here, we used direct labeling of B cells reactive with the N-acetyl-D-glucosamine (GlcNAc)-containing Lancefield group A carbohydrate of Streptococcus pyogenes to study the effects of bacterial antigens on the emergent B-1 B cell clonal repertoire. The number, phenotype, and BCR clonotypes of GlcNAc-reactive B-1 B cells were modulated by neonatal exposure to heat-killed S. Read More

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http://dx.doi.org/10.1016/j.immuni.2020.06.006DOI Listing

Necrobiosis Lipoidica in a Patient with β-Thalassemia Major: A Case Report and Review of the Literature.

Hemoglobin 2020 Jul 1:1-3. Epub 2020 Jul 1.

Adult Thalassemia Unit, Second Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Necrobiosis lipoidica (NL) is a rare granulomatous disease that predominantly affects middle-aged women and is often associated with diabetes mellitus (DM), rheumatoid arthritis (RA) and other metabolic disorders. Thalassemias are the most common hereditary hemoglobin (Hb) disorders worldwide. A few studies investigated dermatologic problems that coexist with β-thalassemia major (β-TM). Read More

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http://dx.doi.org/10.1080/03630269.2020.1783287DOI Listing

Background Glucocorticoid Therapy Has No Impact on Efficacy and Safety of Abatacept or Adalimumab in Patients with Rheumatoid Arthritis.

J Clin Med 2020 Jun 26;9(6). Epub 2020 Jun 26.

Rheumatology Centre, Toulouse University Hospital and University Toulouse III Paul Sabatier, 31059 Toulouse, France.

To date, the impact of background glucocorticoids (GC) on the efficacy and safety of abatacept or adalimumab in patients with active rheumatoid arthritis (RA) is not clearly established. This post hoc analysis of (AMPLE) trial (NCT00929864) compared efficacy and safety outcomes over 2 years in patients treated with abatacept or adalimumab plus background methotrexate (MTX), who continued GC (≤10 mg/day) versus those who were not receiving GC (no-GC). Of 646 randomized patients, 317 received abatacept + MTX (161 GC, 156 no-GC) and 326 received adalimumab + MTX (162 GC, 164 no-GC). Read More

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http://dx.doi.org/10.3390/jcm9062017DOI Listing

Anti-Cyclic Citrullinated Peptide Antibodies Correlate to Ultrasound Synovitis in Rheumatoid Arthritis Better Than C-Reactive Protein.

J Clin Rheumatol 2020 Jun 23. Epub 2020 Jun 23.

From the Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, National Taiwan University Hospital.

Objectives: The aim of this study was to compare ultrasound (US) grading and laboratory measures in patients with rheumatoid arthritis.

Methods: Two-hundred four patients with rheumatoid arthritis who received US evaluation for synovitis were included after excluding those using tocilizumab. Ultrasound grading of synovial hypertrophy (SH) and power Doppler (PD) at the most severe site were recorded. Read More

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http://dx.doi.org/10.1097/RHU.0000000000001499DOI Listing

[Frequency of sarcopenia and factors associated with lean mass in women with rheumatoid arthritis].

Ter Arkh 2020 Jun 5;92(5):15-21. Epub 2020 Jun 5.

Nasonova Research Institute of Rheumatology.

Aim: To evaluate the frequency of sarcopenia (SP) according to EWGSOP2 criteria and factors associated with low lean mass in women with rheumatoid arthritis (RA).

Materials And Methods: 79 women (aged 4075 years) with RA were enrolled in the study. We analyzed clinical data: age, body mass index (BMI), disease duration, methotrexate use, glucocorticoid use, anthropometric measurements, C-reactive protein level, disease activity score in 28 joints-erythrocyte sedimentation rate, bone mineral density (BMD) of the lumbar spine, femur neck, total hip and body composition by Dual energy X-ray absorptiometry. Read More

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http://dx.doi.org/10.26442/00403660.2020.05.000622DOI Listing

[Endothelial damage and circadian blood pressure profile in rheumatoid arthritis].

Ter Arkh 2019 May 15;91(5):89-95. Epub 2019 May 15.

Yaroslavl State Medical University of the Ministry of Healthcare of the Russian Federation.

Aim: To study the influence of the state of endothelium on the daily profile of arterial pressure (AP) in patients with rheumatoid arthritis (RA).

Materials And Methods: In 70 RA pts carried out C-reactive protein (CRP), vascular endothelial adhesion molecule type 1 (sVCAM-1), antigen von Willebrand Factor (AG WF), interleukin-8 (Il-8), rheumatoid factor (RF), IgG, endotheline-1 (ET-1), number of desquamated endotheliocytes cells (DE), VS, activity of renin by immunoenzyme analysis. The dysfunction of endothelium was evaluated by calculation of DE. Read More

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http://dx.doi.org/10.26442/00403660.2019.05.000052DOI Listing

[The role of laboratory biomarkers in monitoring of rituximab biosimilar therapy (Acellbia, "BIOCAD") in patients with rheumatoid arthritis].

Ter Arkh 2019 May 15;91(5):26-33. Epub 2019 May 15.

V.A. Nasonova Scientific and Research Institute of Rheumatology.

Aim: to evaluate the role of laboratory biomarkers in monitoring effectiveness of rituximab (RTM) biosimilar therapy in a total dose of 1200 mg.

Materials And Methods: 20 patients (pts) with rheumatoid arthritis (RA) (18 woman, mean age 61.5(54-66. Read More

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http://dx.doi.org/10.26442/00403660.2019.05.000230DOI Listing

[Chronic pain and depression in patients with rheumatoid arthritis: results of five - year follow - up].

Ter Arkh 2019 May 15;91(5):8-18. Epub 2019 May 15.

Moscow Research Institute of Psychiatry - Branch National Medical Research Center of Psychiatry and Narcology, Ministry of Health of Russia.

The aim of the study was to analyze the factors affecting chronic pain in patients with rheumatoid arthritis (RA).

Materials And Methods: 128 patients with reliable diagnosis of RA [111 (86.7%) women and 17 (13. Read More

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http://dx.doi.org/10.26442/00403660.2019.05.000207DOI Listing

Modified Si-Miao Pill for Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.

Evid Based Complement Alternat Med 2020 21;2020:7672152. Epub 2020 May 21.

Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

Objective: The aim of this review and meta-analysis was to assess the effects and safety of modified Si-Miao pill (mSMP) in treatment of rheumatoid arthritis.

Design: A systematic literature search was carried out in eight databases from their available dates of inception to April 2020. After screening, fifteen randomized, controlled trials (RCTs) comparing the effects and safety of mSMP in combination with western medicine (including disease-modifying antirheumatic drugs (DMARDs) and nonsteroidal anti-inflammatory drugs (NSAIDs)) in treating rheumatoid arthritis patients were included after screening. Read More

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http://dx.doi.org/10.1155/2020/7672152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261325PMC

Case of acute arthritis following SARS-CoV-2 infection.

Ann Rheum Dis 2020 Jun 26. Epub 2020 Jun 26.

Department of Pathology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan.

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http://dx.doi.org/10.1136/annrheumdis-2020-218281DOI Listing

Clinical Characteristics of frailty in Japanese Rheumatoid Arthritis Patients.

Authors:
I Yoshii M Kondo

J Frailty Aging 2020 ;9(3):158-164

Ichiro Yoshii, Yoshii Hospital, Shimanto-City, Kochi Prefecture Japan,

Objective: The relationship between clinical characteristics and frailty was investigated in rheumatoid arthritis (RA) patients >40 years old.

Methods: RA patients followed for >1 year were interviewed and diagnosed as frail according to a 5-item frailty score index: (1) weight loss >2 kg within 6 months (WL); (2) slower gait speed (GS); (3) exercise less than once per week (EX); (4) decline in short-term memory (SM); and (5) general fatigue in the past 2 weeks (GF). The relationship between frailty status and background parameters was evaluated. Read More

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http://dx.doi.org/10.14283/jfa.2020.1DOI Listing
January 2020

Decoy Receptor 3 Promotes Preosteoclast Cell Death via Reactive Oxygen Species-Induced Fas Ligand Expression and the IL-1/IL-1 Receptor Antagonist Pathway.

Mediators Inflamm 2020 10;2020:1237281. Epub 2020 Jun 10.

Department and Graduate Institute of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan.

Purpose: Interleukin-1 (IL-1) is a potent cytokine that plays a role in inflammatory arthritis and bone loss. Decoy receptor 3 (DCR3) is an immune modulator of monocytes and macrophages. The aim of this study was to investigate the mechanism of DCR3 in IL-1-induced osteoclastogenesis. Read More

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http://dx.doi.org/10.1155/2020/1237281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303756PMC

[Postinfectious reactive arthritis after chlamydia infection in competitive sports : Clinical management and current literature review].

Orthopade 2020 Jun 24. Epub 2020 Jun 24.

Klinik für Allgemeine Orthopädie und Tumororthopädie, Universitätsklinikum Münster, Albert-Schweitzer Campus 1, 48149, Münster, Deutschland.

Background: Reactive arthritis following infection with chlamydia is a rare but important differential diagnosis in atraumatic joint swelling. A delayed diagnosis often leads to prolonged periods of absence from physical activity. This can have serious consequences, especially for the career of competitive athletes. Read More

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http://dx.doi.org/10.1007/s00132-020-03935-3DOI Listing

Patients with surgically treated culture-negative native joint septic arthritis have less severe disease and better outcomes.

Infect Dis (Lond) 2020 Jun 24:1-8. Epub 2020 Jun 24.

Beth Israel Deaconess Medical Center, Boston, MA, USA.

Patients with culture-negative septic arthritis patients are often treated surgically but might be successfully managed medically. We compared clinical characteristics and outcomes in patients with culture negative and culture positive native joint monoarticular septic arthritis. This retrospective study included all patients age ≥18 years admitted to a single, tertiary-care hospital between 1998 and 2015 with native joint monoarticular SA and treated with antibiotics and surgery. Read More

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http://dx.doi.org/10.1080/23744235.2020.1784455DOI Listing

The effect of methotrexate on neutrophil reactive oxygen species and CD177 expression in rheumatoid arthritis.

Clin Exp Rheumatol 2020 Jun 23. Epub 2020 Jun 23.

Rheumatology Unit, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Objectives: Neutrophils are found in abundance in the synovial fluid of patients with rheumatoid arthritis (RA), where they are activated and show high reactive oxygen species (ROS) production. However, there is limited data on circulating neutrophils in peripheral blood of patients with RA in terms of ROS production, expression of activation markers and the effect of treatment with methotrexate (MTX) on ROS.

Methods: This single-centre prospective study recruited patients of RA classified as per the 2010 ACR/EULAR criteria. Read More

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Higher prevalence of thyroid dysfunction in patients with erythrodermic psoriasis.

J Dermatol 2020 Jun 22. Epub 2020 Jun 22.

Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.

The association of psoriasis with thyroid dysfunction has been investigated. However, it remains unclear; some papers indicate it, and others do not. In this study, we evaluate the prevalence of thyroid dysfunction in patients with psoriasis vulgaris (PsV), psoriatic arthritis (PsA), generalized pustular psoriasis (GPP) and erythrodermic psoriasis (EP), and the association of thyroid dysfunction with inflammation. Read More

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http://dx.doi.org/10.1111/1346-8138.15427DOI Listing

Nivolumab-induced synovitis is characterized by florid T cell infiltration and rapid resolution with synovial biopsy-guided therapy.

J Immunother Cancer 2020 Jun;8(1)

College of Medicine & Public Health, Flinders University, Adelaide, South Australia, Australia

Background: Immune checkpoint inhibitors (ICIs) are associated with rheumatic and musculoskeletal immune-related adverse events (irAEs) in 5%-20% of patients. Currently, patients refractory to corticosteroids and conventional disease-modifying antirheumatic drugs (cDMARD) are treated with biological DMARDs (bDMARDs) targeting tumor necrosis factor α (TNFα) and interleukin-6, although without a clear biological rationale. Synovial tissue (ST) biopsy presents a valuable opportunity to investigate irAE pathogenesis and appropriately stratify bDMARD use in refractory irAE patients. Read More

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http://dx.doi.org/10.1136/jitc-2019-000281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311067PMC

Large joint and lower extremity involvement have higher impact on disease outcomes in oligoarticular psoriatic arthritis.

Int J Rheum Dis 2020 Jun 22. Epub 2020 Jun 22.

Faculty of Medicine, Rheumatology, University of Ottawa, Ottawa, ON, Canada.

Objective: Joints with different sizes and anatomical locations can be affected in psoriatic arthritis (PsA). Our aim was to explore the effect of different joint patterns on patient-reported outcomes (PROs) in patients with mono-oligoarthritis.

Methods: Within PsArt-ID (Psoriatic Arthritis- International Database), 387/1670 patients who had mono-oligoarthritis (1-4 tender and swollen joints) were enrolled in cross-sectional assessment. Read More

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http://dx.doi.org/10.1111/1756-185X.13887DOI Listing

TNF-α inhibitor therapy can improve the immune imbalance of CD4+ T cells and negative regulatory cells but not CD8+ T cells in ankylosing spondylitis.

Arthritis Res Ther 2020 06 19;22(1):149. Epub 2020 Jun 19.

Department of Rheumatology and Immunology, Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, 510630, Guangdong, China.

Background: Studies into ankylosing spondylitis (AS) and its relationship with immune imbalance are controversial, and the correlation between the efficacy of TNF-α inhibitor and changes in immune imbalance is unclear.

Methods: A total of 40 immune cells were tested with flow cytometry, and the results of 105 healthy control (HC) subjects, 177 active-stage AS patients, and 23 AS cases before and after 12 weeks of TNF-α inhibitor therapy (Anbainuo) were analyzed.

Results: Compared with the HC group, the proportion of immune cells, such as naïve and central memory CD4+T cells, in AS increased (P < 0. Read More

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http://dx.doi.org/10.1186/s13075-020-02226-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304211PMC

A Systematic Review Comparing Experimental Design of Animal and Human Methotrexate Efficacy Studies for Rheumatoid Arthritis: Lessons for the Translational Value of Animal Studies.

Animals (Basel) 2020 Jun 17;10(6). Epub 2020 Jun 17.

SYRCLE, Department for Health Evidence (section HTA), Radboud Institute for Health Sciences, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands.

Increased awareness and understanding of current practices in translational research is required for informed decision making in drug development. This paper describes a systematic review of methotrexate for rheumatoid arthritis, comparing trial design between 147 animal and 512 human studies. Animal studies generally included fewer subjects than human studies, and less frequently reported randomisation and blinding. Read More

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http://dx.doi.org/10.3390/ani10061047DOI Listing

Effect of reactive oxygen species of the psoas major muscle in complete Freund's adjuvant-induced inflammatory pain in rats.

Mol Pain 2020 Jan-Dec;16:1744806920929246

Department of Anesthesiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Lower limb pain is a common clinical disease that affects millions of people worldwide. It is found in previous studies that reactive oxygen species is closely related to neuropathic, cancer, chemotherapy, and inflammatory pain, which can be relieved by reactive oxygen species scavengers. Furthermore, acupuncture or electroacupuncture on the psoas major muscle has a great effect on adjuvant-induced arthritis and lower back pain. Read More

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http://dx.doi.org/10.1177/1744806920929246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303503PMC

Bacterial citrullinated epitopes generated by infection-a missing link for ACPA production.

Ann Rheum Dis 2020 Jun 12. Epub 2020 Jun 12.

Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Corporate Member of Free University Berlin, Humboldt University Berlin and Berlin Institute of Health, Berlin, Germany

Objectives: (.) is discussed to be involved in triggering self-reactive immune responses. The aim of this study was to investigate the autocitrullinated prokaryotic peptidylarginine deiminase (PPAD) from . Read More

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http://dx.doi.org/10.1136/annrheumdis-2019-216919DOI Listing

Changes in Plasma Itaconate Elevation in Early Rheumatoid Arthritis Patients Elucidates Disease Activity Associated Macrophage Activation.

Metabolites 2020 Jun 10;10(6). Epub 2020 Jun 10.

Institute of Infection, Immunity and Inflammation, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK.

Changes in the plasma metabolic profile were characterised in newly diagnosed rheumatoid arthritis (RA) patients upon commencement of conventional disease-modifying anti-rheumatic drug (cDMARD) therapy. Plasma samples collected in an early RA randomised strategy study (NCT00920478) that compared clinical (DAS) disease activity assessment with musculoskeletal ultrasound assessment (MSUS) to drive treatment decisions were subjected to untargeted metabolomic analysis. Metabolic profiles were collected at pre- and three months post-commencement of nonbiologic cDMARD. Read More

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http://dx.doi.org/10.3390/metabo10060241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344783PMC

Ultrasound liver elastography for the detection of liver fibrosis in patients with psoriasis and reactive arthritis on long-term methotrexate therapy: A cross-sectional study.

Indian J Dermatol Venereol Leprol 2020 Jun 8. Epub 2020 Jun 8.

Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.

Background: Long-term low-dose methotrexate therapy is associated with liver fibrosis. Although liver biopsy is the gold standard for detecting fibrosis, it is an invasive procedure associated with morbidity and mortality risks. Hence noninvasive imaging techniques such as transient elastography (TE) and shear wave elastography (SWE) have been studied to measure liver stiffness. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_425_19DOI Listing
June 2020
1.325 Impact Factor

Outcome domains reported in calcium pyrophosphate deposition studies: A scoping review by the OMERACT CPPD working group.

Semin Arthritis Rheum 2020 May 30;50(4):719-727. Epub 2020 May 30.

Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand.

Introduction: Although calcium pyrophosphate deposition (CPPD) is common, there are no validated outcome domains and/or measurements for CPPD studies. The aim of this work was to identify domains that have been reported in prior clinical studies in CPPD, to inform the development of a core set of domains for CPPD studies.

Methods: We performed a scoping literature review for clinical studies in CPPD, searching in Medline (via PubMed), EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) databases; published from January 1, 1946 to January 7, 2020. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2020.05.015DOI Listing

Comparative evaluation of efficacy, pharmacodynamics, and safety of Hetero's adalimumab (Mabura®, Hetero Biopharma Ltd.) and reference adalimumab (Humira®, Abbvie Inc.) in patients with active rheumatoid arthritis on concomitant methotrexate therapy.

BMC Rheumatol 2020 4;4:24. Epub 2020 Jun 4.

Sapthagiri Institute of Medical Sciences and Research Center #15, Chikkasandra, Hesaraghatta Main Road, Bangalore, Karnataka 560090 India.

Background: Our study aimed to compare efficacy and safety of Hetero's adalimumab (Mabura®, Hetero Biopharma Limited) versus reference adalimumab (Humira®, Abbvie Inc.) in Indian patients with active rheumatoid arthritis (RA) concomitant on methotrexate (MTX) therapy.

Methods: Patients ( = 168) were randomized (2:1) to receive either test or reference product for 24 weeks with concomitant MTX. Read More

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http://dx.doi.org/10.1186/s41927-020-00124-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271501PMC

Evaluating upadacitinib for the treatment of rheumatoid arthritis.

Expert Opin Pharmacother 2020 Jun 9:1-9. Epub 2020 Jun 9.

Rheumatology, Organizacion Medica De Investigacion SA , Buenos Aires, Argentina.

Introduction: The introduction of JAKs inhibitors for the treatment of rheumatoid arthritis represents a promising new era in the management of the disease. New compounds under investigation, like upadacitinib, with greater selectivity for JAK1 inhibition have recently been approved for the treatment of adults with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to conventional synthetic disease-modifying antirheumatic drugs.

Areas Covered: Herein, the authors review the pharmacological data, the therapeutic efficacy, and safety data of upadacitinib before providing the reader with their critical evaluation and future perspectives. Read More

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http://dx.doi.org/10.1080/14656566.2020.1774555DOI Listing

Oral health-related quality of life in different rheumatic diseases.

Oral Dis 2020 Jun 8. Epub 2020 Jun 8.

Department of Cardiology, Angiology and Nephrology, Medizinische Hochschule Brandenburg, Brandenburg, Germany.

Objectives: Aim of this cross-sectional study was to investigate oral health-related quality of life (OHRQoL) of patients with different rheumatic diseases.

Subjects And Methods: Patients with rheumatic disease, including rheumatoid arthritis (RA), systemic lupus erythematodes (SLE), systemic sclerosis (SSc), ankylosing spondylitis (AS), psoriatic arthritis (PsA) and vasculitis were included. OHRQoL was assessed with the German short form of oral health impact profile (OHIP G14). Read More

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http://dx.doi.org/10.1111/odi.13464DOI Listing

Sex differences in frailty and its association with low bone mineral density in rheumatoid arthritis.

Bone Rep 2020 Jun 22;12:100284. Epub 2020 May 22.

Department of Medicine, Division of Rheumatology, University of California, San Francisco, San Francisco, CA, USA.

Objectives: Frailty in the general population is associated with poor health outcomes including low bone mass and osteoporotic fracture. The relationship between frailty and low bone mineral density (BMD) in rheumatoid arthritis (RA) is unknown. This study examined associations between frailty and BMD in RA, controlling for established osteoporosis risk factors. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264043PMC

A Systematic Review of Activity of Medicinal Plants from Sub-Saharan Africa against spp.

Evid Based Complement Alternat Med 2020 15;2020:9485364. Epub 2020 May 15.

Faculdade de Veterinária, Universidade Eduardo Mondlane, Avenida de Moçambique, Km 1.5, Maputo, Mozambique.

Introduction: spp. are zoonotic bacteria that cause gastroenteritis in humans and may cause extraintestinal infections such as Guillain-Barré syndrome, reactive arthritis, and bacteremia. Resistance to antibiotics is an increasing concern in the Sub-Saharan Africa; thus, search for alternatives such as plant-based active ingredients is important in order to develop new drugs. Read More

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http://dx.doi.org/10.1155/2020/9485364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245682PMC

C-Reactive Protein Promotes the Activation of Fibroblast-Like Synoviocytes From Patients With Rheumatoid Arthritis.

Front Immunol 2020 20;11:958. Epub 2020 May 20.

Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen, China.

To evaluate the biological effect and mechanisms of C-reactive protein (CRP) on the activation of fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA). To understand if CRP is involved in RA, expression of CRP and its receptors CD32/64 was examined in synovial tissues from RA patients and normal controls. , the potential role and mechanisms of CRP in FLS proliferation and invasion, expression of pro-inflammatory cytokines, and activation of signaling pathways were investigated in both RA - FLS and a normal human fibroblast-like synoviocyte line (HFLS). Read More

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http://dx.doi.org/10.3389/fimmu.2020.00958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251027PMC

Editorial Commentary: Optimizing Surgical Management of Ankle Fractures: Is Arthroscopy the Answer?

Authors:
Thomas I Sherman

Arthroscopy 2020 06;36(6):1722-1724

Lancaster, Pennsylvania.

The surgical management of ankle fractures can be an unforgiving endeavor. Subtle malreductions in fracture fragments lead to significant deviations in joint reactive forces and, consequently, accelerated arthritis. The diagnosis of associated ligamentous pathology, such as deltoid and syndesmotic injuries, is often difficult and ideal surgical management is debated. Read More

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http://dx.doi.org/10.1016/j.arthro.2020.03.022DOI Listing

The Heterogeneity of Pediatric Knee Infections: A Retrospective Analysis.

J Pediatr Orthop 2020 Jul;40(6):314-321

Departments of Orthopaedics and Rehabilitation.

Background: Musculoskeletal infection is a major cause of morbidity in the pediatric population. Despite the canonical teaching that an irritable joint and signs of infection likely represent an infected joint space, recent evidence in the pediatric hip has demonstrated that alternative diagnoses are equally or more likely and that combinations of pathologies are common. The knee is the second most commonly infected joint in children, yet there remains a paucity of available data regarding the epidemiology and workup of the infected pediatric knee. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001425DOI Listing