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J Immunotoxicol 2022 Dec;19(1):53-60

Department of Clinical Laboratory, First Affiliated Hospital of Nanchang University, Nanchang, China.

As an important m6A reader, the YT521-B homology domain family 2 (YTHDF2) has been shown to regulate mRNA degradation and translation, and to be involved in inflammation. However, little is known about the role of YTHDF2 in the autoimmune-based inflammatory disease rheumatoid arthritis (RA). To begin to ascertain any role for this reader, 74 RA patients and 63 healthy controls (HC) were recruited for this study. Read More

Cureus 2022 May 26;14(5):e25346. Epub 2022 May 26.

Internal Medicine, Centro de Medicina de Reabilitação da Região Centro - Rovisco Pais, Tocha, PRT.

Polymyalgia rheumatica (PMR) is an inflammatory rheumatic disease characterized by severe pain and morning stiffness, mainly affecting the shoulder girdle. A 75-year-old woman, previously healthy, received the first dose of ChAdOx1 vaccine and two weeks later started with pain in the shoulder and pelvic girdles and knees of inflammatory characteristics, accompanied by morning stiffness (about one hour), anorexia, asthenia, and activities of daily living (ADL) dependence. She started analgesics and non-steroidal anti-inflammatory drugs (NSAIDs) with no improvement. Read More

Med Eng Phys 2022 Jun 26:103839. Epub 2022 Jun 26.

Department of Ultrasound, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, 450052 China.

Objectives: The purpose of this research was investigate the potential use of MVFI (microvascular flow imaging) in the assessment of tenosynovitis in cases with SNRA (seronegative rheumatoid arthritis).

Methods: Fifty-six SNRA cases and 20 HCs (healthy controls) were enrolled, and all of them were subjected to ultrasonographic examination of the compartments I-VI of the extensor tendons of the wrist, flexor carpi radialis and flexor tendons of the five digits. Each tendon synovial sheath was semi-quantitatively scored by GS (gray-scale) ultrasound, PD (power Doppler) ultrasound, and MVFI. Read More

ACR Open Rheumatol 2022 Jun 30. Epub 2022 Jun 30.

Philadelphia VA Medical Center, Philadelphia, Pennsylvania, USA.

Objective: Despite a wealth of studies evaluating rheumatoid arthritis (RA) therapies, it remains difficult to compare efficacies across trials due to heterogeneous study populations. We sought to identify patient/trial characteristics associated with clinical response to enable fairer comparisons.

Methods: We reviewed 565 disease-modifying antirheumatic drug studies compiled for American College of Rheumatology (ACR) management guidelines. Read More

Arthritis Res Ther 2022 Jun 29;24(1):160. Epub 2022 Jun 29.

Division of Rheumatology, Department of Medicine, University of Washington, 750 Republican Street, Seattle, WA, 98109, USA.

Objective: To assess markers of neutrophil activation such as calprotectin and N-formyl methionine (fMET) in anti-neutrophil cytoplasmic autoantibody-associated vasculitis (AAV) and large-vessel vasculitis (LVV).

Methods: Levels of fMET, and calprotectin, were measured in the plasma of healthy controls (n=30) and patients with AAV (granulomatosis with polyangiitis (GPA, n=123), microscopic polyangiitis (MPA, n=61)), and LVV (Takayasu's arteritis (TAK, n=58), giant cell arteritis (GCA, n=68)), at times of remission or flare. Disease activity was assessed by physician global assessment. Read More

Iran J Immunol 2022 Jun;19(2)

Department of Pharmacy, Jiading District Hospital of Traditional Chinese Medicine, Shanghai 201800, China.

Background: Adult-onset Still's disease (AOSD), which presents many non-specific symptoms, such as rash leukocytosis, spiking fever, and sore throat, is a rare auto inflammatory disease. Other clinical features that are frequently observed include lymphadenopathy, arthralgia, serositis, splenomegaly, and hepatomegaly. Laboratory tests show high levels of C-reactive protein, ferritin, and erythrocyte sedimentation rate reflecting the systemic inflammatory process in AOSD patients. Read More

Int J Rheum Dis 2022 Jun 29. Epub 2022 Jun 29.

Bone Metabolism Laboratory, Rheumatology Division, Faculdade de Medicina FMUSP Universidade de Sao Paulo, Sao Paulo, Brazil.

Aim: To evaluate hand function by hand grip test in rheumatoid arthritis (RA) patients, and its association with bone erosions and the estimated bone strength (finite element - FE analysis) through the analysis of the 2nd metacarpal head of the dominant hand using high resolution peripheral quantitative computed tomography (HR-pQCT).

Method: Eighty-two female RA patients between 18-50 years old were selected. Demographic data, Health Questionnaire Assessment Disability Index (HAQ), Disease Activity Score of 28 joints (DAS)-28, simplified disease activity index (SDAI) and the hand grip test were set. Read More

Zhonghua Nei Ke Za Zhi 2022 Jul;61(7):779-784

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China.

To investigate the relationship between psoriasis severity and clinical features in psoriatic arthritis (PsA). Patients were recruited from the Chinese REgistry of Psoriatic ARthritis (CREPAR) between December 2018 and June 2021, and data were collected including the baseline demographic characteristics, various clinical manifestations (including arthritis, nail disease, comorbidities), laboratory tests[including erythrocyte sedimentation rate(ESR), C-reactive protein (CRP)], health assessment questionnaire (HAQ). Body surface area (BSA) and psoriasis area and severity index (PASI) were selected for the tools of assessment of cutaneous psoriasis. Read More

Eur Cell Mater 2022 Jun 28;43:293-298. Epub 2022 Jun 28.

Department of Orthopaedic Surgery, Orthopaedic Hospital Vienna-Speising, Speisingerstrasse 109, AT-1130 Vienna,

Prior studies have outlined C-reactive protein (CRP) within the first 5 d following total hip arthroplasty (THA) as an inappropriate indicator of an early periprosthetic joint infection (PJI). Recently, interleukin-6 (IL-6), as a potential inflammatory marker following total joint arthroplasty (TJA), has gained increasing interest, particularly due to its considerably shorter half-life. The aim of the present study was to assess IL-6 measured on postoperative day 3 following TJA as a prediction marker of early onset PJI. Read More

Int J Surg Case Rep 2022 Jun 16;96:107316. Epub 2022 Jun 16.

Department of Ophthalmology, Saitama Medical University, Saitama, Japan. Electronic address:

Introduction: Rigid gas permeable (RGP) contact lenses implanted in the upper eyelid may remain asymptomatic. It is important to evert the upper eyelid even in the absence of definite pain.

Presentation Of Case: A 74-year-old woman with a history of rheumatoid arthritis visited a local clinic because of right eye discomfort that had persisted for 5 months. Read More

Immun Inflamm Dis 2022 Jul;10(7):e663

Graduate School, Anhui University of Traditional Chinese Medicine, Hefei, Anhui, China.

Background: Abnormal expression of long noncoding RNAs (lncRNAs) is involved in several autoimmune diseases including rheumatoid arthritis (RA). In this study, we intended to explore the expression of lncRNA LINC00638 in RA and its potential mechanism of action related to inflammation and oxidative stress.

Methods: The level of LINC00638 in the peripheral blood mononuclear cells (PBMCs) obtained from 45 RA patients and 30 normal controls was analyzed and its correlation with clinical indicators was investigated. Read More

IJID Reg 2022 Mar 20;2:162-164. Epub 2022 Jan 20.

Ministry of Health, Muscat, Oman.

is a ubiquitous rapid-growing mycobacterium that belongs to a diverse group of non-tuberculous mycobacteria. It can cause frequent and serious infections in patients with or without risk factors. This article reports a case of disseminated in an immunocompetent Omani male with native joint septic arthritis. Read More

Clin Kidney J 2022 Jul 31;15(7):1373-1378. Epub 2022 Jan 31.

Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

Background: We investigated the incidence of chronic kidney disease (CKD) progression and its factors relevant to patients with stable rheumatoid arthritis (RA).

Methods: We enrolled consecutive patients with RA who had initiated treatment with a biologic disease-modifying anti-rheumatic drug (bDMARD) at our institution and continued the same drug for >5 years between 2001 and 2016. Patients with CKD at bDMARD initiation were excluded. Read More

Int J Rheum Dis 2022 Jun 27. Epub 2022 Jun 27.

Department of Rheumatology, National Hospital Organization Tokyo National Hospital, Tokyo, Japan.

Background: Discordance between patient global assessment (PGA) and physician global assessment (PhGA) of rheumatoid arthritis (RA) disease activity is mainly determined by pain and functional disabilities. This study aimed to investigate the shift in PGA-PhGA discordance and the variables associated with future positive discordance (PGA > PhGA) based on the NinJa database in Japan.

Methods: We examined 7557 adults with RA registered in both NinJa 2014 and 2018, with a discordance cutoff of 3 on a 10-cm scale. Read More

Phytomedicine 2022 May 12;104:154140. Epub 2022 May 12.

Dr.Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau (S.A.R.), China. Electronic address:

Background: Rheumatoid arthritis (RA) is a long-term, progressive, and disabling autoimmune disease. It causes inflammation, swelling and pain in and around the joints and other body organs. Currently, no cure is available for RA. Read More

Hinyokika Kiyo 2022 May;68(5):145-148

The Department of Urology, Hitachi General Hospital.

The patient was a 70-year-old woman who underwent transurethral resection of bladder tumor in May 2020. She was diagnosed with urothelial carcinoma (high grade, pT1 by pathology). We started bacillus Calmette-Guerin (BCG) intravesical infusion (80 mg Tokyo strain) in August of the same year after a second transurethral resection. Read More

Int J Rheum Dis 2022 Jun 24. Epub 2022 Jun 24.

Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.

Background: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder which mainly affects small joints, occurs most commonly in middle-aged adults, and can be fatal in severe cases. The exact etiology of RA remains unknown. However, uncontrolled expression of pro-inflammatory cytokines and chemokines can contribute to the pathogenesis of RA. Read More

J Tradit Complement Med 2022 Jul 24;12(4):414-425. Epub 2021 Dec 24.

Department of Biochemistry, State University of Maringá, PR, Brazil.

Background And Aim: The present study investigated the effects of orally administered α-tocopherol-loaded polycaprolactone nanoparticles on the articular inflammation and systemic oxidative status of middle-aged rats with Freund's adjuvant-induced polyarthritis, a model for rheumatoid arthritis. Intraperitoneally administered free α-tocopherol provided the reference for comparison.

Experimental Procedure: Two protocols of treatment were followed: intraperitoneal administration of free α-tocopherol (100 mg/kg i. Read More

Medicina (Kaunas) 2022 Jun 20;58(6). Epub 2022 Jun 20.

The Clinic of Rheumatology, Traumatology Orthopaedics and Reconstructive Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, M. K. Čiurlionio str. 21, 03101 Vilnius, Lithuania.

Early undifferentiated arthritis (UA) is a group of inflammatory joint diseases that are not classified under any specific rheumatic or connective tissue disorder and might evolve into chronic inflammatory arthritis or may be a self-limiting condition. Early recognition and treatment are crucial for the future course of the disease. Vascular endothelial growth factor (VEGF) is an angiogenic regulator that induces the growth of new capillary blood vessels, which are important in joint invasion and destruction during the progression of chronic inflammatory arthritis. Read More

Antioxidants (Basel) 2022 Jun 13;11(6). Epub 2022 Jun 13.

Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing 100029, China.

Rheumatoid arthritis (RA) is an inflammatory disease that begins with a loss of tolerance to modified self-antigens and immune system abnormalities, eventually leading to synovitis and bone and cartilage degradation. Reactive oxygen species (ROS) are commonly used as destructive or modifying agents of cellular components or they act as signaling molecules in the immune system. During the development of RA, a hypoxic and inflammatory situation in the synovium maintains ROS generation, which can be sustained by increased DNA damage and malfunctioning mitochondria in a feedback loop. Read More

J Mater Chem B 2022 Jun 23. Epub 2022 Jun 23.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.

Psoriasis is a common skin disease with complex pathogenesis that lacks diagnostic methods. Typically, psoriasis is an inflammation-related disease accompanied by high expression of reactive oxygen species (ROS) in the infected part. However, due to the lack of suitable tools, it is difficult to identify the ROS, especially certain types of ROS (, HOCl) in the psoriasis model. Read More

Heart Rhythm O2 2022 Jun 15;3(3):261-268. Epub 2022 Mar 15.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.

Background: Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease associated with atrial fibrillation (AF) and stroke.

Objective: The purpose of this study was to evaluate the safety and efficacy of AF ablation in patients with RA.

Methods: All patients with RA undergoing AF ablation at our institution from 2010 to 2021 were propensity matched to patients without RA using 9 baseline characteristics. Read More

Sci Rep 2022 Jun 22;12(1):10547. Epub 2022 Jun 22.

Vanderbilt University Medical Center, Nashville, TN, USA.

Patients with rheumatoid arthritis (RA) have increased atherosclerosis; oxidative stress may be a contributor. Oxidative stress produces immunogenic malondialdehyde-acetaldehyde (MAA) protein adducts and anti-MAA antibodies are detectable in human serum. We hypothesized that anti-MAA antibody concentrations are associated with coronary atherosclerosis in RA patients. Read More

Free Radic Res 2022 Jun 22:1-13. Epub 2022 Jun 22.

Department of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, India.

Rheumatoid arthritis (RA) is an autoimmune disorder whose etiopathology involves an interplay between genetic and environmental factors, with oxidative stress being a key contributory factor. This study aimed to establish the impact, if any, of an oxidative, pro-inflammatory milieu upon trans-differentiation of neutrophils and disease progression. In the synovial fluid (SF) and peripheral blood sourced from patients with RA ( = 40) along with healthy controls ( = 25), the proportion of neutrophil-dendritic (N-DC) cell hybrids, i. Read More

Sci Rep 2022 Jun 21;12(1):10452. Epub 2022 Jun 21.

Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

To investigate the trend and factors related to the occurrence of osteoarthritis (OA)-like features on knee radiographs of rheumatoid arthritis (RA) patients undergoing total knee arthroplasty (TKA) in the recent decades. To classify antero-posterior knee radiographs into 'RA' and 'OA-like RA' groups, a deep learning model was developed by training the network using knee radiographs of end-stage arthropathy in RA patients obtained during 2002-2005 and in primary OA patients obtained during 2007-2009. We used this model to categorize 796 knee radiographs, which were recorded in RA patients before TKA during 2006-2020, into 'OA-like RA' and 'RA' groups. Read More

BMJ Open 2022 Jun 21;12(6):e061917. Epub 2022 Jun 21.

College of Pharmacy, Daegu Catholic University, Gyeongsan, South Korea

Introduction: Rheumatoid arthritis (RA) generally requires lifelong treatment; however, its medication complexity might affect non-adherence. Pharmacist-led telehealth services were as effective as face-to-face services and reduced potential side effects in outpatients with chronic diseases. This study aims to analyse the effect of a telepharmacy service with a customised mobile device in comparison with the usual pharmacist service on the humanistic and clinical outcomes in patients with RA. Read More

J Bone Joint Surg Am 2022 Jun 20. Epub 2022 Jun 20.

Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: Septic arthritis (SA) is a musculoskeletal emergency for which prompt diagnosis and treatment are critical. However, traditional diagnostic criteria of a synovial fluid (SF) white blood-cell count (WBC) of >50,000 cells/mm3 or >90% polymorphonuclear leukocytes (%PMN) are not particularly sensitive or specific for the diagnosis of SA. Furthermore, prognostic markers are lacking. Read More

Front Immunol 2022 2;13:909760. Epub 2022 Jun 2.

National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States.

Background And Objectives: Psoriasis is a heterogeneous inflammatory disease that involves the skin, joints, liver, heart, and other organs. Psoriatic arthritis (PsA) is associated with cardiovascular disease (CVD), but the relative contributions of inflammatory and metabolic dysregulation to CVD are incompletely understood. We set out to discover novel potential contributors to CVD in PsA patients by comprehensively phenotyping a cohort of PsA patients using these advanced technologies. Read More

Int Orthop 2022 Jun 20. Epub 2022 Jun 20.

Department of Orthopedics, Orthopedic Research Institute, West China Hospital, SiChuan University, No.37, Guoxue Road, Wuhou district, Chengdu, 610041, Sichuan, People's Republic of China.

Background: Total hip arthroplasty (THA) is considered the best treatment for sequelae of suppurative hip arthritis, but such patients are more likely to have occult infection and therefore to suffer post-operative periprosthetic joint infection. Our study examined (1) the occult infection rate among patients with sequelae of suppurative hip arthritis, and whether (2) neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), or fibrinogen levels can be used to screen such patients for occult infection before THA.

Methods: We retrospectively enrolled 428 patients who underwent primary THA at our hospital between 2010 and 2021, of whom 31 had occult infection and 397 did not. Read More

Inflammation 2022 Jun 17. Epub 2022 Jun 17.

Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Science, Sari, Iran.

Rheumatoid arthritis (RA) is a chronic, debilitating systemic disease characterized by chronic inflammation and progressive joint destruction. Fibroblast-like synoviocytes (FLSs) are one of the most important players in the pathophysiology of RA, acting like tumor cells and secreting inflammatory cytokines. Previous research has shown that cold atmospheric plasma (CAP) inhibits cancer cells and may have anti-inflammatory properties. Read More