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    A randomised phase IIb study of mavrilimumab, a novel GM-CSF receptor alpha monoclonal antibody, in the treatment of rheumatoid arthritis.
    Ann Rheum Dis 2017 Feb 17. Epub 2017 Feb 17.
    Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA.
    Objectives: Despite the therapeutic value of current rheumatoid arthritis (RA) treatments, agents with alternative modes of action are required. Mavrilimumab, a fully human monoclonal antibody targeting the granulocyte-macrophage colony-stimulating factor receptor-α, was evaluated in patients with moderate-to-severe RA.

    Methods: In a phase IIb study (NCT01706926), patients with inadequate response to ≥1 synthetic disease-modifying antirheumatic drug(s), Disease Activity Score 28 (DAS28)-C reactive protein (CRP)/erythrocyte sedimentation rate ≥3. Read More

    Anti-TNF-induced remission in very early peripheral spondyloarthritis: the CRESPA study.
    Ann Rheum Dis 2017 Feb 17. Epub 2017 Feb 17.
    Department of Rheumatology, Ghent University Hospital, Ghent, Belgium.
    Objective: To evaluate the efficacy and safety of golimumab to induce clinical remission in patients with very early, active peripheral spondyloarthritis (pSpA).

    Methods: Clinical REmission in peripheral SPondyloArthritis is a monocentric study of golimumab treatment in patients with pSpA. All patients fulfilled the Assessment of SpondyloArthritis international Society classification criteria for pSpA, with a symptom duration ≤12 weeks. Read More

    Seven-year tolerability profile of glucocorticoids use in early rheumatoid arthritis: data from the ESPOIR cohort.
    Ann Rheum Dis 2017 Feb 17. Epub 2017 Feb 17.
    Rheumatology Department, Lapeyronie Hospital, Montpellier University, Montpellier, France.
    Objective: To explore the 7-year tolerability profile of glucocorticoids (GC) for early rheumatoid arthritis (RA).

    Methods: We examined data for 602 patients with RA from the early arthritis Etude et Suivi des POlyarthrites Indifférenciées Récentes (ESPOIR) cohort (<6 months disease duration) stratified into two groups: with or without GC treatment at least once during follow-up (median 7 years (IQR 0.038-7. Read More

    Low serum iron is associated with high serum intact FGF23 in elderly men: The Swedish MrOS study.
    Bone 2017 Feb 14. Epub 2017 Feb 14.
    Center for Bone and Arthritis Research (CBAR), Departments of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden; Dept of Geriatric Medicine, Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. Electronic address:
    Background: Fibroblast growth factor (FGF23) is a protein that is produced by osteoblasts and osteocytes. Increased serum levels of FGF23 have been associated with increased risks of osteoporotic fractures and cardiovascular disease, particularly in participants with poor renal function. Serum iron (Fe) has been suggested as a regulator of FGF23 homeostasis. Read More

    Micro RNA-146a But Not IRAK1 is Associated with Rheumatoid Arthritis in the Tunisian Population.
    Genet Test Mol Biomarkers 2017 Feb;21(2):92-96
    1 Laboratory of Immunology , Research Unit UR 807, Faculty of Medicine of Sousse, Sousse, Tunisia .
    Background: Rheumatoid arthritis (RA) is characterized by the production of an array of proinflammatory cytokines through the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. Interleukin-1 receptor (IL-1R) and Toll-like receptors contain a common cytoplasmic motif the Toll/IL-1R (TIR) homology domain. This motif is required for NF-κB activation. Read More

    Circulating adiponectin and visfatin levels in rheumatoid arthritis and their correlation with disease activity: A meta-analysis.
    Int J Rheum Dis 2017 Feb 16. Epub 2017 Feb 16.
    Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
    Aim: This study aimed to evaluate the relationship between circulating adiponectin and visfatin levels and rheumatoid arthritis (RA) and to establish a correlation between serum adipokine levels and RA activity.

    Methods: We conducted meta-analyses on serum/plasma adiponectin or visfatin levels in patients with RA and controls and correlation coefficients between circulating adiponectin and visfatin levels and Disease Activity Score of 28 joints (DAS28) in RA patients.

    Results: Eleven studies comprising 813 RA patients and 684 controls were included in this meta-analysis. Read More

    [Clinical and laboratory features of macrophage activation syndrome].
    Zhongguo Dang Dai Er Ke Za Zhi 2017 Feb;19(2):188-192
    Department of Rheumatology, Immunology and Allergy, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
    Objective: To study the clinical and laboratory features of macrophage activation syndrome (MAS) at the early stage of diagnosis, and to explore a method for early identification of MAS.

    Methods: A retrospective analysis was performed for the demographic data, clinical and laboratory features, and treatment outcomes of 21 MAS patients.

    Results: Of the 21 MAS patients, 14 had systemic juvenile idiopathic arthritis, 5 had Kawasaki disease (KD), and 2 had connective tissue disease (CTD) as primary diseases. Read More

    Dihydroorotate dehydrogenase (DHODH) inhibitors affect ATP depletion, endogenous ROS and mediate S-phase arrest in breast cancer cells.
    Biochimie 2017 Feb 11. Epub 2017 Feb 11.
    Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address:
    Dihydroorotate dehydrogenase (DHODH) is the key enzyme in de novo biosynthesis of pyrimidine in both prokaryotes and eukaryotes. The de novo pathway of pyrimidine biosynthesis is essential in cancer cells proliferation. Leflunomide is an approved DHODH inhibitor that has been widely used for the treatment of arthritis. Read More

    Retrospective study of the clinical characteristics and risk factors of rheumatoid arthritis-associated interstitial lung disease.
    Clin Rheumatol 2017 Feb 12. Epub 2017 Feb 12.
    Department of Rheumatology and Immunology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, Beijing, 100020, China.
    This study aims to explore the clinical characteristics and risk factors of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD). This is a retrospective study of 550 patients with RA. All patients underwent chest high-resolution computed tomography (HRCT) scanning. Read More

    Receptor activator of nuclear factor kappa-B ligand (RANKL) but not sclerostin or gene polymorphisms is related to joint destruction in early rheumatoid arthritis.
    Clin Rheumatol 2017 Feb 11. Epub 2017 Feb 11.
    Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, SE-901 85, Umeå, Sweden.
    The aim of this study was to analyze relationships between receptor activator of nuclear factor kappa-B (RANKL), sclerostin and their gene polymorphisms with radiological progression in patients with early rheumatoid arthritis (RA). Patients with early RA (n = 407, symptomatic <1 year) (ARA criteria) examined radiologically at inclusion and after 24 months were consecutively included. Disease activity score and C-reactive protein were regularly recorded. Read More

    Low dose prednisolone and insulin sensitivity differentially affect arterial stiffness and endothelial function: An open interventional and cross-sectional study.
    Atherosclerosis 2017 Jan 31;258:34-39. Epub 2017 Jan 31.
    School of Medicine, Flinders University, Adelaide, Australia; Southern Adelaide Diabetes & Endocrine Services, Repatriation General Hospital, Adelaide, Australia. Electronic address:
    Background And Aims: Glucocorticoids could impair vascular function directly, or indirectly by reducing insulin sensitivity. The aim of this study was to determine the direct and indirect effects of acute and chronic low dose prednisolone on arterial stiffness and endothelial function.

    Methods: Twelve subjects with inflammatory arthritis, who had not taken oral glucocorticoids for ≥6 months, and 12 subjects with inflammatory arthritis, taking chronic (>6 months) low dose (6. Read More

    In vivo hypoxia PET imaging quantifies the severity of arthritic joint inflammation in line with overexpression of HIF and enhanced ROS generation.
    J Nucl Med 2017 Feb 9. Epub 2017 Feb 9.
    Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Germany.
    Hypoxia is essential for the development of autoimmune diseases such as rheumatoid arthritis (RA) and is associated with the expression of reactive oxygen species (ROS), due to enhanced infiltration of immune cells. The aim of this study was to demonstrate the feasibility of measuring hypoxia non-invasively in vivo in arthritic ankles with positron emission tomography (PET)/magnetic resonance imaging (MRI) using the hypoxia tracers (18)F-fluoromisonidazole (FMISO) and (18)F-fluoroazomycinarabinoside (FAZA). Additionally, we quantified temporal dynamics of hypoxia and ROS stress using L-012, a ROS-sensitive chemiluminescence optical imaging (OI) probe, and analyzed the activation of hypoxia inducible factors (HIFs). Read More

    Endothelial injury in rheumatoid arthritis: a crosstalk between dimethylarginines and systemic inflammation.
    Arthritis Res Ther 2017 Feb 10;19(1):32. Epub 2017 Feb 10.
    Arthritis Research UK Epidemiology Unit, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.
    Background: Symmetric (SDMA) and asymmetric (ADMA) dimethylarginines have emerged as novel biomarkers of cardiovascular disease (CVD) in several disease settings associated with atherosclerosis. Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by high CVD mortality and morbidity. ADMA and SDMA levels are abnormal in RA patients, but their correlation with assessments of endothelial function and structure remains unknown. Read More

    Inflammatory Markers and Disease Activity in Juvenile Idiopathic Arthritis.
    Indian J Pediatr 2017 Feb 8. Epub 2017 Feb 8.
    Department of Pediatrics, Institute of Postgraduate Medical Education & Research (I.P.G.M.E.& R.), 244, AJC Bose Road, Kolkata, 700020, India.
    Objective: To evaluate the post treatment changes in disease activity and inflammatory markers over time in longitudinal follow-up involving different subtypes of juvenile idiopathic arthritis (JIA) patients.

    Methods: This prospective longitudinal study, carried out over a period of 2 y, included JIA patients, both old and new, with high disease activity. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), ferritin, CHAQ (Childhood Health Assessment Questionnaire) score and JADAS27 (Juvenile Arthritis Disease Activity score with 27 active joint counts) were estimated at the initial visit, 6 mo, 12 mo and 18 mo of follow-up. Read More

    Failure of a systemic lupus erythematosus response index developed from clinical trial data: lessons examined and learned.
    Lupus 2017 Jan 1:961203317692433. Epub 2017 Jan 1.
    1 Cedars-Sinai Medical Center, Division of Rheumatology, USA.
    Background Our primary goal was to create an outcome change score index similar to a standard rheumatoid arthritis (RA) model utilizing real-world data in systemic lupus erythematosus (SLE) patients that occurred during their phase 3 trials with a Food and Drug Administration-approved drug. Methods We utilized raw data from trials of belimumab for the treatment of SLE. Data were split 80/20 into training/validation sets. Read More

    C5a Regulates IL-1β Production and Leukocyte Recruitment in a Murine Model of Monosodium Urate Crystal-Induced Peritonitis.
    Front Pharmacol 2017 23;8:10. Epub 2017 Jan 23.
    Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (ASTAR) Singapore, Singapore.
    Gouty arthritis results from the generation of monosodium urate (MSU) crystals within joints. These MSU crystals elicit acute inflammation characterized by massive infiltration of neutrophils and monocytes that are mobilized by the pro-inflammatory cytokine IL-1β. MSU crystals also activate the complement system, which regulates the inflammatory response; however, it is unclear whether or how MSU-mediated complement activation is linked to IL-1β release in vivo, and the various roles that might be played by individual components of the complement cascade. Read More

    Clinical Significance of Red Blood Cell Distribution Width and Inflammatory Factors for the Disease Activity in Rheumatoid Arthritis.
    Clin Lab 2016 Dec;62(12):2327-2331
    Background: To evaluate the significance of red blood cell distribution width (RDW) and other factors for the disease activity in rheumatoid arthritis (RA).

    Methods: Each patient underwent clinical examination and blood sampling for assessment of serum high-sensitivity C-reactive protein (hs-CRP) levels, erythrocyte sedimentation rate (ESR), hemoglobin concentration (Hb), hematocrit (HCT), RDW, and other erythrocyte parameters (mean corpuscular volume [MCV], mean cell Hb [MCH], mean corpuscular Hb concentration [MCHC]). Rheumatoid factors (RF-IgA, -IgG, -IgM) and anti-cyclic citrullinated protein antibodies (anti-CCP) were purified from the plasma and detected by ELISA. Read More

    The adjuvant use of calcium fructoborate and borax with etanercept in patients with rheumatoid arthritis: Pilot study.
    J Intercult Ethnopharmacol 2017 Jan-Mar;6(1):58-64. Epub 2016 Dec 8.
    Department of Medicine, College of Medicine, University of Baghdad, Baghdad, Iraq.
    Objective: This study was designed to evaluate the effects calcium fructoborate (CFB) and sodium tetraborate (NTB) as supplements in Iraqi patients with active rheumatoid arthritis (RA) maintained on etanercept.

    Materials And Methods: A double-blind randomized placebo-controlled clinical trial with 60 days treatment period was carried out at Baghdad Teaching Hospital, Medical city, Baghdad, Iraq. Eighty RA patients were randomized into three groups to receive either 220 mg/day CFB, 55 mg/day NTB in capsule dosage form (equivalent to 6 mg elemental Boron), or placebo formula once daily. Read More

    Positive selection of type II collagen-reactive CD80(high) marginal zone B cells in DBA/1 mice.
    Clin Immunol 2017 Feb 2. Epub 2017 Feb 2.
    Division of Immunobiology, Sungkyunkwan University School of Medicine, Suwon, Gyeonggi-do 16419, Republic of Korea; Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul 06351, Republic of Korea. Electronic address:
    To investigate whether dysregulated selection of autoreactive marginal zone (MZ) B cells is involved in autoimmune diseases, we examined MZ B cell profile in multiple strains of mice, and found that type II collagen (CII)-reactive autoreactive CD80(high) MZ B cells spontaneously developed in the DBA/1, but not in C57BL/6 mice. CD80(high) MZ B cells that were characteristically found in DBA/1 mice expressed higher levels of TACI, SLAM3, and SLAM6 than the usual CD80(low) MZ B cells. Notably, the CD80(high) MZ B cells were more sensitive to ibrutinib, a Bruton's tyrosine kinase inhibitor, than CD80(low) MZ or follicular B cells and their transient depletion via intravenous injection of ibrutinib significantly delayed the induction of collagen-induced arthritis (CIA). Read More

    Less Than Ideal Cardiovascular Health Is Associated With Shorter Leukocyte Telomere Length: The National Health and Nutrition Examination Surveys, 1999-2002.
    J Am Heart Assoc 2017 Feb 2;6(2). Epub 2017 Feb 2.
    Cardiovascular disease Section, Social Epidemiology Research Unit, Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
    Background: The associations between individual cardiovascular disease risk factors and leukocyte telomere length (LTL) have been inconclusive. We investigated the association between LTL and overall cardiovascular health (CVH) as defined by the American Heart Association and whether the association is modified by sex and race/ethnicity.

    Methods And Results: We included 5194 adults (aged ≥20) from the National Health and Nutrition Examination Survey 1999-2002. Read More

    Retrospective study of prognostic factors in pediatric invasive pneumococcal disease.
    PeerJ 2017 25;5:e2941. Epub 2017 Jan 25.
    Hsinchu MacKay Memorial Hospital , Hsinchu , Taiwan.
    Streptococcus pneumoniae remains the leading causative pathogen in pediatric pneumonia and bacteremia throughout the world. The invasive pneumococcal disease (IPD) is known as isolation of S. pneumoniae from a normally sterile site (e. Read More

    Blood chemokine profile in untreated early rheumatoid arthritis: CXCL10 as a disease activity marker.
    Arthritis Res Ther 2017 Feb 2;19(1):20. Epub 2017 Feb 2.
    Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy of University of Gothenburg, Box 480, S-405 30, Gothenburg, Sweden.
    Background: We have recently analyzed the profile of T-cell subtypes based on chemokine receptor expression in blood from untreated early rheumatoid arthritis (ueRA) patients compared to healthy controls (HC). Here, we compared the levels of the respective chemokines in blood plasma of ueRA patients with those of HC. We also studied the association of chemokine levels with the proportions of circulating T-cell subsets and the clinical disease activity. Read More

    A longitudinal study of fecal calprotectin and the development of inflammatory bowel disease in ankylosing spondylitis.
    Arthritis Res Ther 2017 Feb 2;19(1):21. Epub 2017 Feb 2.
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at the University of Gothenburg, Guldhedsgatan 10A, S-413 46, Gothenburg, Sweden.
    Background: Patients with ankylosing spondylitis (AS) are at increased risk of developing inflammatory bowel disease (IBD). We aimed to determine the variation in fecal calprotectin in AS over 5 years in relation to disease activity and medication and also to study the incidence of and predictors for development of IBD.

    Methods: Fecal calprotectin was assessed at baseline (n = 204) and at 5-year follow-up (n = 164). Read More

    A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases.
    Nat Genet 2017 Jan 30. Epub 2017 Jan 30.
    Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
    Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with a strong genetic component characterized by autoantibody production and a type I interferon signature. Here we report a missense variant (g.74779296G>A; p. Read More

    Effectiveness of leucocyte esterase as a diagnostic test for acute septic arthritis.
    J Orthop Surg (Hong Kong) 2017 Jan;25(1):2309499016685019
    2 Lok Nayak Hospital, New Delhi, India.
    Background: We hypothesized that leucocyte esterase strip test can aid in diagnosing septic arthritis in native synovial fluid because leucocyte esterase concentrations would be elevated at the infection site because of secretion by recruited neutrophils.

    Method: The cohort included 27 patients (suspected septic arthritis and normal subjects). A standard chemical test strip (graded as negative, trace, +, ++ or +++) was used to detect the presence of leucocyte esterase. Read More

    [Reactive arthritis due to Clostridium difficile: Report of two cases and literature review].
    Rev Med Interne 2017 Jan 24. Epub 2017 Jan 24.
    Service de médecine interne, institut hospitalier Franco-Britannique, 92300 Levallois-Perret, France.
    Introduction: Reactive arthritis due to Clostridium difficile infection is uncommon.

    Case Reports: We report two cases of reactive arthritis associated with C. difficile infection that occurred in a 40-year-old woman and a 47-year-old man. Read More

    Monogenic Auto-inflammatory Syndromes: A Review of the Literature.
    Iran J Allergy Asthma Immunol 2016 Dec;15(6):430-444
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
    Auto-inflammatory syndromes are a new group of distinct hereditable disorders characterized by episodes of seemingly unprovoked inflammation (most commonly in skin, joints, gut, and eye), the absence of a high titer of auto-antibodies or auto-reactive T cells, and an inborn error of innate immunity. A narrative literature review was carried out of studies related to auto-inflammatory syndromes to discuss the pathogenesis and clinical manifestation of these syndromes. This review showed that the main monogenic auto-inflammatory syndromes are familial Mediterranean fever (FMF), mevalonate kinase deficiency (MKD), Blau syndrome, TNF receptor-associated periodic syndrome (TRAPS), cryopyrin-associated periodic syndrome (CAPS), and pyogenic arthritis with pyoderma gangrenosum and acne (PAPA). Read More

    PAD4 Inhibition is Sufficient for the Amelioration of Collagen-Induced Arthritis.
    Clin Exp Immunol 2017 Jan 27. Epub 2017 Jan 27.
    Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045.
    Citrullination of joint proteins by the PAD family of enzymes is increasingly recognized as a key process in the pathogenesis of rheumatoid arthritis. This present study was undertaken to explore the efficacy of a novel PAD4-selective inhibitor, GSK199, in the murine collagen-induced arthritis model of rheumatoid arthritis. Mice were dosed daily from the time of collagen immunization with GSK199. Read More

    Oxygen and indocyanine green loaded phase-transition nanoparticle-mediated photo-sonodynamic cytotoxic effects on rheumatoid arthritis fibroblast-like synoviocytes.
    Int J Nanomedicine 2017 9;12:381-393. Epub 2017 Jan 9.
    Department of Pharmacy, First Affiliated Hospital of Chongqing Medical University.
    Background: Photodynamic therapy and sonodynamic therapy are developing, minimally invasive, and site-specific modalities for cancer therapy. A combined strategy PSDT (photodynamic therapy followed by sonodynamic therapy) has been proposed in this study. Here, we aimed to develop novel biodegradable poly(DL-lactide-co-glycolic acid) phase-transition nanoparticles simultaneously loaded with oxygen and indocyanine green (OI-NPs) and to investigate the cytotoxic effects and the potential mechanisms of OI-NP-mediated PSDT on MH7A synoviocytes. Read More

    Gray scale and power Doppler ultrasonographic findings in the assessment of disease activity and their correlation with disease activity parameters in rheumatoid arthritis.
    Curr Rheumatol Rev 2017 Jan 19. Epub 2017 Jan 19.
    Himalayan Institute of Medical Sciences - Department of Medicine Dehradun, Uttarakhand, India.
    Objectives: To study the utility of gray scale and power Doppler ultrasonography in assessing the disease activity and correlation of ultrasonographic findings with disease activity parameters in rheumatoid arthritis (RA).

    Materials And Methods: This cross-sectional study was conducted on 100 RA patients diagnosed as per 2010 classification criteria. Rheumatoid factor (RF), serum anti-cyclic citrullinated peptide antibodies (ACPA), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), disease activity score with 28-joint counts and ESR (DAS28-ESR), visual analogue scale (VAS) for global disease activity and gray scale ultrasonography (GSUS) and power Doppler ultrsonography (PDUS) scores in hands and wrists were determined. Read More

    Frailty and reduced physical function go hand in hand in adults with rheumatoid arthritis: a US observational cohort study.
    Clin Rheumatol 2017 Jan 23. Epub 2017 Jan 23.
    Division of Rheumatology, University of California San Francisco, San Francisco, CA, 94143, USA.
    Reduced physical function and health-related quality of life are common in rheumatoid arthritis (RA), and further studies are needed that examine novel determinates of reduced physical function in RA. This study examines whether frailty, a state of increased vulnerability to stressors, is associated with differences in self-reported physical function among adults with RA. Adults from a longitudinal RA cohort (n = 124) participated in the study. Read More

    Drug interaction between methotrexate and salazosulfapyridine in Japanese patients with rheumatoid arthritis.
    J Pharm Health Care Sci 2017 19;3. Epub 2017 Jan 19.
    0000 0001 2308 3329grid.9707.9Department of Medicinal Informatics, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641 Japan ; 0000 0001 2308 3329grid.9707.9Department of Hospital Pharmacy, University Hospital, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641 Japan.
    Background: Methotrexate (MTX) and salazosulfapyridine (SASP) are disease-modifying drugs that are commonly used in the treatment of rheumatoid arthritis (RA), and combination therapy with MTX and SASP is recommended for RA patients who show an inadequate response to monotherapy with either drug. This study was designed to examine the interaction between the two drugs from the viewpoint of serum MTX concentration in Japanese RA patients, who were receiving combination therapy with relatively low doses of MTX and SASP.

    Methods: This is a 24-week open-label intervention study of stable RA patients (n = 10) with low disease activity. Read More

    Selected issues in diagnostic imaging of spondyloarthritides: psoriatic arthritis and juvenile spondyloarthritis.
    Reumatologia 2016 30;54(6):310-317. Epub 2016 Dec 30.
    Department of Radiology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
    Spondyloarthritides (also known as spondyloarthropathies) are a group of rheumatic diseases that consists of diversified entities, i.e. ankylosing spondylitis, reactive arthritis, psoriatic arthritis, arthritis in the course of Crohn's disease and ulcerative colitis, and juvenile spondyloarthropathies. Read More

    Calprotectin in rheumatic diseases: a review.
    Reumatologia 2016 30;54(6):306-309. Epub 2016 Dec 30.
    Department of Internal Medicine and Rheumatology, Katowice, Poland.
    Calprotectin also known as MRP8/14 or S100A8/A9 is a heterodimeric complex of two S100 calcium-binding proteins: myeloid-related protein 8 (MRP-8 or S100A8) and MRP-14 (or S100A9). At present, according to many authors, it is considered that calprotectin MRP8/14 is a potentially more sensitive biomarker of disease activity in rheumatoid disease than conventional inflammatory indices such as the erythrocyte sedimentation rate, C-reactive protein and others. A review of the literature on concentration of calprotectin in patients with some rheumatic diseases (rheumatoid arthritis, juvenile idiopathic arthritis, adult-onset Still's disease, systemic vasculitis, polymyalgia rheumatica, ankylosis spondylitis, systemic lupus erythematosus, and primary Sjögren's syndrome) is presented. Read More

    Diet quality of individuals with rheumatoid arthritis using the Healthy Eating Index (HEI)-2010.
    Nutr Health 2017 Jan 1:260106016688223. Epub 2017 Jan 1.
    1 Department of Nutrition and Food Studies, New York University Steinhardt, New York, NY, USA.
    Background: Rheumatoid arthritis (RA) afflicts approximately 1.5 million American adults and is a major cause of disability. As disease severity worsens, individuals with RA may experience functional decline that can impact dietary intake. Read More

    Mycoplasma bovis escapes bovine neutrophil extracellular traps.
    Vet Microbiol 2017 Feb 23;199:68-73. Epub 2016 Dec 23.
    Animal Health Laboratory, Graduate School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan. Electronic address:
    Mycoplasma bovis is a significant pathogen in bovine infections including mastitis, pneumonia, arthritis and otitis media, and is the cause of large economic losses in beef and dairy farms. During infection with M. bovis, recruited neutrophils are not sufficient to eradicate M. Read More

    Highly Expression of CD11b and CD32 on Peripheral Blood Mononuclear Cells from Patients with Adult-Onset Still's Disease.
    Int J Mol Sci 2017 Jan 19;18(1). Epub 2017 Jan 19.
    Department of Microbiology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 443-380, Korea.
    Background: We investigated the potential role of several pattern-recognition receptors (PRRs; CD11b, CD11c, CD32, CD206, CD209, and dectin-1) in adult-onset Still's disease (AOSD).

    Methods: The study included 13 untreated AOSD patients, 19 rheumatoid arthritis (RA) patients (as a disease control), and 19 healthy controls (HCs). The PRRs were quantified in peripheral blood using flow cytometry. Read More

    Clinical significance of soluble CD163 in polymyositis-related or dermatomyositis-related interstitial lung disease.
    Arthritis Res Ther 2017 Jan 19;19(1). Epub 2017 Jan 19.
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan.
    Background: Macrophage activation is involved in the pathogenesis of polymyositis (PM)/dermatomyositis (DM). CD163, a scavenger receptor expressed on the surface of activated macrophages, mediates anti-inflammatory functions. This study aimed to evaluate the clinical significance of soluble CD163 (sCD163) in PM/DM-related interstitial lung disease (ILD). Read More

    Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases.
    Adv Nutr 2017 Jan 17;8(1):54-62. Epub 2017 Jan 17.
    Glycation, Oxidation, and Disease Laboratory, Department of Research, College of Osteopathic Medicine, Touro University California, Vallejo, CA
    Fructose is associated with the biochemical alterations that promote the development of metabolic syndrome (MetS), nonalcoholic fatty liver disease, and type 2 diabetes. Its consumption has increased in parallel with MetS. It is metabolized by the liver, where it stimulates de novo lipogenesis. Read More

    Treatment of rheumatoid arthritis with combination of methotrexate and Tripterygium wilfordii: A meta-analysis.
    Life Sci 2017 Jan 11. Epub 2017 Jan 11.
    College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China. Electronic address:
    Aims: Extracts of Tripterygium wilfordii Hook F (TwHF), a traditional Chinese herbal medicine, have been widely used for treating rheumatoid arthritis (RA) in combination with methotrexate (MTX) in China for several decades. However, the efficacy and safety of MTX plus TwHF treatment remain unclear.

    Main Methods: A comprehensive search of databases in both Chinese and English was performed. Read More

    Comparison of cardiovascular risk algorithms in patients with vs without rheumatoid arthritis and the role of C-reactive protein in predicting cardiovascular outcomes in rheumatoid arthritis.
    Rheumatology (Oxford) 2017 Jan 12. Epub 2017 Jan 12.
    Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA.
    Objectives: The aims were to compare the performance of cardiovascular risk calculators, Framingham Risk Score (FRS) and QRISK2, in RA and matched non-RA patients and to evaluate whether their performance could be enhanced by the addition of CRP.

    Methods: We conducted a retrospective analysis, using a clinical practice data set linked to Hospital Episode Statistics (HES) data from the UK. Patients presenting with at least one RA diagnosis code and no prior cardiovascular events were matched to non-RA patients using disease risk scores. Read More

    Plant Lectins Activate the NLRP3 Inflammasome To Promote Inflammatory Disorders.
    J Immunol 2017 Jan 13. Epub 2017 Jan 13.
    Institute of Immunology and the Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic Disease, Chinese Academy of Sciences Center for Excellence in Molecular Cell Sciences, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei 230027, China;
    Plant-derived dietary lectins have been reported to be involved in the pathogenesis of several inflammatory diseases, including inflammatory bowel disease, diabetes, rheumatoid arthritis, and celiac disease, but little is known about the molecular mechanisms underlying lectin-induced inflammation. In this study, we showed that plant lectins can induce caspase-1 activation and IL-1β secretion via the NLRP3 inflammasome. Lectins were internalized and subsequently escaped from the lysosome and then translocated to the endoplasmic reticulum. Read More

    Calprotectin (S100A8/A9) has the strongest association with ultrasound-detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis.
    Arthritis Res Ther 2017 Jan 12;19(1). Epub 2017 Jan 12.
    Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
    Background: Calprotectin (S100A8/A9 or MRP8/14) and S100A12 (leukocyte-derived proteins), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) are markers of inflammation and angiogenesis. Ultrasound (US) is sensitive for detection of greyscale synovitis and power Doppler (PD) vascularization. The objective of the present study was to explore the associations between calprotectin, S100A12, IL-6, VEGF, erythrocyte sedimentation rate, C-reactive protein and a comprehensive US assessment in patients with rheumatoid arthritis (RA) starting biologic disease-modifying anti-rheumatic drug (bDMARD) treatment. Read More

    Endovascular Management of Central Retinal Arterial Occlusion.
    Vasc Endovascular Surg 2016 Nov;50(8):579-581
    1 Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA.
    Background And Importance: Central retinal artery occlusion (CRAO) is an ophthalmologic emergency due to the sudden cessation of circulation to the inner retinal layer. Without immediate treatment, permanent blindness may ensue. Several treatment options exist, ranging from noninvasive medical management to thrombolysis. Read More

    Collective Genetic Interaction Effects and the Role of Antigen-Presenting Cells in Autoimmune Diseases.
    PLoS One 2017 12;12(1):e0169918. Epub 2017 Jan 12.
    Biotechnology High-Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Maryland, United States of America.
    Autoimmune diseases occur when immune cells fail to develop or lose their tolerance toward self and destroy body's own tissues. Both insufficient negative selection of self-reactive T cells and impaired development of regulatory T cells preventing effector cell activation are believed to contribute to autoimmunity. Genetic predispositions center around the major histocompatibility complex (MHC) class II loci involved in antigen presentation, the key determinant of CD4+ T cell activation. Read More

    ECG non-specific ST-T and QTc abnormalities in patients with systemic lupus erythematosus compared with rheumatoid arthritis.
    Lupus Sci Med 2016 16;3(1):e000168. Epub 2016 Dec 16.
    Columbia University, College of Physicians & Surgeons , New York, New York , USA.
    Objectives: Cardiovascular disease (CVD) is a leading cause of death in systemic lupus erythematosus (SLE) and in rheumatoid arthritis (RA). Although only explored in one study, ECG non-specific ST-T abnormalities, in addition to corrected QT-interval (QTc) prolongation, were recently reported in an SLE inception cohort. Importantly, these ECG abnormalities are known predictors of CVD mortality in the general population, yet their prevalence in patients with established SLE has not been evaluated. Read More

    No further gain can be achieved by calculating Disease Activity Score in 28 joints with high-sensitivity assay of C-reactive protein because of high intraindividual variability of C-reactive protein: A cross-sectional study and theoretical consideration.
    Medicine (Baltimore) 2017 Jan;96(1):e5781
    aDepartment of Rheumatology, Svendborg Hospital, Odense University Hospital, Svendborg bUniversity of Southern Denmark, Odense cDanbio, Copenhagen dDepartment of Clinical Biochemistry, Svendborg Hospital, Odense University Hospital, Svendborg, Denmark.
    Disease Activity Score in 28 joints (DAS28) is commonly used to evaluate disease activity of rheumatoid arthritis (RA) and is a guide to treatment decision.The aim of this study was to evaluate the impact of lower reporting limit for C-reactive protein (CRP), with respect to intraindividual biological variability, on the calculation of DAS28 and subsequent patient classification.This study consists of 2 sections: a theoretical consideration discussing the performance of CRP in calculating DAS28 taking intraindividual biological variation and lower reporting limit for CRP into account and a cross-sectional study of RA patients applying our theoretical results. Read More

    Anti-rheumatoid Arthritis Effect of Kaejadan via Analgesic and Antiinflammatory Activity in vivo and in vitro.
    Phytother Res 2017 Jan 9. Epub 2017 Jan 9.
    College of Korean Medicine, Kyung Hee University, 1 Hoegidong, Dongdaemungu, Seoul, 131-701, Korea.
    Although Kaejadan (KJD), an herbal cocktail of three medicinal plants (Lithospermum erythrorhizon, Cinnamomum loureirii, and Salvia miltiorrhiza), has been traditionally used for the treatment of rheumatoid arthritis, its scientific evidence is not fully understood. Hence, we investigated antiinflammatory and analgesic mechanism of KJD in vivo and in vitro. Kaejadan suppressed the number of writhing responses in mice treated by acetic acid and showed antinociceptive effect by tail-flick test. Read More

    Berberine, an isoquinoline alkaloid suppresses TXNIP mediated NLRP3 inflammasome activation in MSU crystal stimulated RAW 264.7 macrophages through the upregulation of Nrf2 transcription factor and alleviates MSU crystal induced inflammation in rats.
    Int Immunopharmacol 2017 Mar 7;44:26-37. Epub 2017 Jan 7.
    Immunopathology Lab, School of Bio Sciences and Technology, VIT University, Vellore 632 014, Tamil Nadu, India. Electronic address:
    The current study was designed to investigate the therapeutic potential of berberine on monosodium urate (MSU) crystal stimulated RAW 264.7 macrophages and in MSU crystal induced rats. Our results indicate that berberine (25, 50 and 75μM) suppressed the levels of pro-inflammatory cytokines (interleukin-1beta (IL-1β) and tumor necrosis factor alpha (TNFα)) and intracellular reactive oxygen species in MSU crystal stimulated RAW 264. Read More

    Pathobiochemical Mechanisms Relating Iron Homeostasis to Parameters of Inflammatory Activity and Autoimmune Disorders in Rheumatoid Arthritis.
    Folia Med (Plovdiv) 2016 Dec;58(4):257-263
    Aim: To find the correlations between the parameters of iron homeostasis, inflammatory activity and autoimmune disorders in rheumatoid arthritis (RA).

    Materials And Methods: The present study included 114 patients with RA and 42 healthy controls. We determined the parameters of iron homeostasis: serum iron, total iron binding capacity (TIBC), ferritin and soluble transferrin receptor (sTfR), the parameters of inflammatory activity: C-reactive protein (CRP), interleukin-6 (IL-6) and prohepcidin, and the parameters of autoimmune disorders: rheumatoid factor (RF), anti-cyclic citrullinated peptide (antiCCP) antibodies, and DAS 28. Read More

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