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    Patient Factors Associated With Methicillin-Resistant Staphylococcus aureus Septic Arthritis in Children.
    Orthopedics 2018 Feb 16:1-6. Epub 2018 Feb 16.
    Staphylococcus aureus is the most common causative organism in pediatric septic arthritis, with methicillin-resistant Staphylococcus aureus (MRSA) being responsible for a significant portion of these infections. Early identification and initiation of proper treatment may improve outcomes by minimizing potential morbidity. The purpose of this study was to identify variables obtained on initial patient presentation associated with MRSA septic arthritis. Read More

    Repository corticotropin injection in patients with rheumatoid arthritis resistant to biologic therapies.
    Open Access Rheumatol 2018 7;10:13-19. Epub 2018 Feb 7.
    Division of Rheumatology, Southcoast Health, Fall River, MA, USA.
    Introduction: Although synthetic and biologic disease-modifying antirheumatic drugs are available, many patients with rheumatoid arthritis have a difficult-to-control disease and need other treatment options. Repository corticotropin injection (RCI) may alleviate symptoms and exacerbations in patients with refractory disease.

    Methods: Nine patients with refractory rheumatoid arthritis were included in this study. Read More

    Assessment of effectiveness and safety of biosimilar infliximab (CT-P13) in a real-life setting for treatment of patients with active rheumatoid arthritis or ankylosing spondylitis.
    Curr Med Res Opin 2018 Feb 13:1-12. Epub 2018 Feb 13.
    d Rheumatology, Medical University of Plovdiv, UMHAT "Kaspela" , Plovdiv , Bulgaria.
    Objective: To assess the effectiveness and safety of infliximab biosimilar, CT-P13, administered in a real-life setting to adult patients with active rheumatoid arthritis (RA) or ankylosing spondylitis (AS).

    Methods: This multicentre, non-interventional, observational study was conducted in Bulgaria, Czech Republic and Romania. A total of 151 patients with severe active RA (n = 81) or AS (n = 70) were enrolled and treated with CT-P13 for 24 weeks, according to current medical recommendations. Read More

    Redox responses are preserved across muscle fibres with differential susceptibility to aging.
    J Proteomics 2018 Feb 10. Epub 2018 Feb 10.
    Physiology Department, School of Medicine, National University of Ireland Galway, Ireland. Electronic address:
    Age-related loss of muscle mass and function is associated with increased frailty and loss of independence. The mechanisms underlying the susceptibility of different muscle types to age-related atrophy are not fully understood. Reactive oxygen species (ROS) are recognised as important signalling molecules in healthy muscle and redox sensitive proteins can respond to intracellular changes in ROS concentrations modifying reactive thiol groups on Cysteine (Cys) residues. Read More

    Herbal products for common auto-inflammatory disorders - Novel approaches.
    Comb Chem High Throughput Screen 2018 Feb 12. Epub 2018 Feb 12.
    Department of Health Sciences, Faculty of Science, University of Mauritius, 230 Reduit. Mauritius.
    Common auto-inflammatory disorders (CAIDs) induce considerable suffering over the world. A panoply of synthetic medications areis available for theirits management. Nonetheless, available drug classes are limited by adverse effects, low systemic absorption, and high costs. Read More

    CT assessment of axillary lymphadenopathy in patients with rheumatoid arthritis: association with disease activity and severity.
    Rheumatol Int 2018 Feb 12. Epub 2018 Feb 12.
    Department of Rheumatology, Yachiyo Medical Center, Tokyo Women's Medical University, 477-96 Owadashinden, Yachiyo, Chiba, 276-8524, Japan.
    Background: Axillary lymph nodes (ALNs) are often seen on chest computed tomography (CT) in rheumatoid arthritis (RA) patients. Early reports described lymphadenopathy as one of the systemic manifestations rather than regional lymphadenopathy secondary to drainage from the affected joints. Subsequently, the importance of the immunological events occurring in draining lymph nodes in the development of arthritis was documented. Read More

    Folate conjugated Superoxide Dismutase adsorbed over antioxidant mimicking nanomatrix frameworks for treatment of Rheumatoid Arthritis.
    J Pharm Sci 2018 Feb 5. Epub 2018 Feb 5.
    University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur C.G 492010; National Centre for Natural Resources, Pt. Ravishankar Shukla University, Raipur C.G 492010. Electronic address:
    Rheumatoid arthritis (RA) is an autoimmune disease occurring in larger population, characterized by synovial inflammation followed by destruction of joint. Major concerned factor for cause of Rheumatoid arthritis (RA) has been related to oxidative stress due to environmental toxicity and immune imbalance. Reactive oxygen species (ROS) generated from macrophages commune series of oxidation at cellular and genetic level and leads to generation of inflammatory cytokines for provoking inflammation in RA. Read More

    The Sex Influence on Response to Tumor Necrosis Factor-α Inhibitors and Remission in Axial Spondyloarthritis.
    J Rheumatol 2018 Feb;45(2):195-201
    From the Dipartimento di Medicina e Scienze della Salute "Vincenzo Tiberio," Università degli Studi del Molise, Campobasso; Day Hospital of Rheumatology, Azienda Sistema Socio Sanitario (ASST) Centro Specialistico Ortopedico Traumatologico G. Pini-Centro Specialistico Traumatologico-Ortopedico (CTO), Milan; Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Matera; La Struttura Semplice Dipartimentale (SSD) di Medicina e Reumatologia, Istituto Ortopedico Rizzoli, Università di Bologna, Bologna; Rheumatology Unit, Department of Clinical and Experimental Medicine (DIMED), University of Padua, Padua; Rheumatology Unit, Azienda Ospedaliera-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) di Reggio Emilia and Università di Modena e Reggio Emilia, Reggio Emilia, Italy.
    Objective: The aim of this study was to evaluate the influence of sex on response to treatment and disease remission in patients with axial spondyloarthritis (axSpA).

    Methods: In this retrospective multicenter study, patients with axSpA, according to the Assessment of Spondyloarthritis international Society (ASAS) criteria for axSpA, and treated with adalimumab, etanercept, golimumab, or infliximab, were studied. We compared clinical characteristics, patient-reported outcomes, disease activity, function, and response to treatment in male and female patients with this disease. Read More

    Malondialdehyde-acetaldehyde antibody concentrations in rheumatoid arthritis and other rheumatic conditions.
    Int Immunopharmacol 2018 Feb 1;56:113-118. Epub 2018 Feb 1.
    Veterans Affairs (VA) Nebraska-Western Iowa Health Care System, Omaha, NE, United States; Department of Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, United States.
    Objective: To compare anti-malondialdehyde-acetaldehyde (MAA) antibody concentrations between rheumatoid arthritis (RA) patients and healthy and rheumatic disease controls.

    Methods: Anti-MAA antibody (IgA, IgM, IgG) was measured using ELISA and banked serum from patients with RA (n = 284), osteoarthritis (OA, n = 330), spondyloarthropathy (SpA, n = 50), and systemic lupus erythematosus (SLE, n = 88) as well as healthy controls (n = 82). Anti-MAA antibody concentrations and the frequency of positivity were compared across groups. Read More

    Unsaturated aldehyde, 4-hydroxynonenal (HNE) alters the structural integrity of HSA with consequences in the immuno-pathology of rheumatoid arthritis.
    Int J Biol Macromol 2018 Jan 31;112:306-314. Epub 2018 Jan 31.
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, U.P., India.
    Human serum albumin (HSA) - the most abundant plasma protein plays an important role in the transport of endogenous and exogenous molecules in the body. Its modifications have been implicated in a variety of pathological disorders. We have studied the interaction of HNE with HSA at a molecular level by docking experiment and the results suggest a strong interaction between HNE and HSA. Read More

    Involvement of foot in patients with spondyloarthritis: Prevalence and clinical features.
    Foot Ankle Surg 2017 Nov 10. Epub 2017 Nov 10.
    Department of Rheumatology, Charles Nicolle Hospital, 1006 Tunis, Tunisia; Université de Tunis El Manar, Faculté de Médecine de Tunis, 1007 Tunis, Tunisia.
    Background: The purpose of this study was to evaluate the foot involvement in a group of patients with spondyloarthritis in regard to symptoms, type and frequency of deformities, location and radiological changes.

    Methods: We conducted a cross sectional study including 60 patients with spondyloarthritis over a period of six months. Anamnesis, clinical examination, podoscopic examination, biological tests and X-rays of feet were done for each patient. Read More

    Contribution of bacterial pathogens to evoking serological disease markers and aggravating disease activity in rheumatoid arthritis.
    PLoS One 2018 6;13(2):e0190588. Epub 2018 Feb 6.
    Katayama Orthopedic Rheumatology Clinic, Asahikawa, Hokkaido, Japan.
    Commensal bacteria and their pathogenic components in the gastrointestinal tract and oral cavity may play pathological roles in autoimmune diseases. To study the possible involvement of bacterial pathogens in autoimmune diseases, IgG and IgA antibodies against pathogenic components produced by three strains of commensal bacteria, Escherichia coli-lipopolysaccharide (E. coli-LPS), Porphyromonas gingivalis-LPS (Pg-LPS) and peptidoglycan polysaccharide (PG-PS) from Streptococcus pyogenes, were determined by an improved ELISA system for sera from two groups of patients with rheumatoid arthritis (RA), who met rapid radiographic progression (RRP) criteria and non-RRP, and compared to normal (NL) controls. Read More

    Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice.
    Aging Cell 2018 Feb 6. Epub 2018 Feb 6.
    Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
    Moment-to-moment adjustment of cerebral blood flow (CBF) via neurovascular coupling has an essential role in maintenance of healthy cognitive function. In advanced age, increased oxidative stress and cerebromicrovascular endothelial dysfunction impair neurovascular coupling, likely contributing to age-related decline of higher cortical functions. There is increasing evidence showing that mitochondrial oxidative stress plays a critical role in a range of age-related cellular impairments, but its role in neurovascular uncoupling remains unexplored. Read More

    Detection of Shigella spp. nucleic acids in the synovial tissue of Tunisian rheumatoid arthritis patients and other forms of arthritis by quantitative real-time polymerase chain reaction.
    Rheumatol Int 2018 Feb 5. Epub 2018 Feb 5.
    Laboratoire Immunologie rhumatologie, EPS La Rabta, Université Tunis-Elmanar, Tunisie, rue 7051 Centre Urbain Nord, 1082, Tunis, Tunisia.
    Enterobacterial components in the joints of patients are believed to contribute to a perpetuating inflammation leading to a reactive arthritis (ReA), a condition in which microbial agents cannot be recovered from the joint. At present, it is unclear whether nucleic acids from Shigella spp. are playing a pathogenic role in causing not only ReA but also other forms of arthritis. Read More

    Methotrexate Dose in Patients With Early Rheumatoid Arthritis Impacts Methotrexate Polyglutamate Pharmacokinetics, Adalimumab Pharmacokinetics, and Efficacy: Pharmacokinetic and Exposure-response Analysis of the CONCERTO Trial.
    Clin Ther 2018 Feb;40(2):309-319
    Department of Clinical Pharmacology and Pharmacometrics, AbbVie Inc, North Chicago, Illinois.
    Purpose: Methotrexate (MTX) and adalimumab are well-recognized treatments of rheumatoid arthritis (RA), the efficacy of which may be driven by intracellular polyglutamates (PGs). The aim of this analysis was to characterize MTX PG concentrations and adalimumab pharmacokinetics in the CONCERTO trial. In addition, the relationships between MTX dose/pharmacokinetics, adalimumab pharmacokinetics, and efficacy were evaluated. Read More

    Differential diagnostic perspectives provided by en face microscopic examination of articular surface defects.
    Clin Rheumatol 2018 Feb 4. Epub 2018 Feb 4.
    Department of Vertebrate Paleontology, Carnegie Museum, Pittsburgh, PA, 15213, USA.
    Surface defects have a central position in diagnosis of articular pathology. Recognizing the limitations of standard radiologic techniques and those imposed by positioning and averaging artifacts on CT evaluation, direct visualization of surface defects was pursued to identify disease characteristics that would facilitate interpretation of radiologic findings. Epi-illumination surface microscopy was utilized to examine macroscopically recognized articular surface defects in individuals in the Hamann-Todd, Terry, and Huntington human skeletal collections with previously verified diagnoses of rheumatoid arthritis, spondyloarthropathy, juvenile inflammatory arthritis (JIA), calcium pyrophosphate deposition disease (CPPD), gout, metastatic cancer, multiple myeloma, septic arthritis, tuberculosis, fungal arthritis, histiocytosis and sickle cell anemia (Rothschild and Rothschild Clin Infect Dis 20(5):1402-1408, 1995; Rothschild et al. Read More

    Utility of Serological Markers for Detecting Persistent Infection in Two-Stage Revision Arthroplasty in Patients With Inflammatory Arthritis.
    J Arthroplasty 2017 Dec 29. Epub 2017 Dec 29.
    Department of Orthopedic Surgery, Cleveland Clinic, Cleveland, OH.
    Background: Serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are commonly used for the diagnosis of persistence of infection after the first stage of 2-stage revision arthroplasty for periprosthetic joint infection (PJI). As both ESR and CRP are markers of systemic inflammation, the utility of these tests to monitor infection clearance in patients with inflammatory arthritis is unclear.

    Methods: From 2001 to 2016, 44 two-stage revision total hip or knee arthroplasties in patients with an inflammatory arthritis diagnosed by a rheumatologist were identified. Read More

    Different ethnic background is associated with distinct clinical profiles in the spondyloarthritides in the North and South of Brazil.
    Clin Rheumatol 2018 Feb 1. Epub 2018 Feb 1.
    Division of Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
    The objective of this study was to analyze the clinical profile of the spondyloarthritides (SpA) in distinct Brazilian regions. A common protocol of investigation was prospectively applied to 202 SpA patients, including 138 patients from the South and 64 patients from the North. All the patients were classified as axial or peripheral SpA. Read More

    Validating an Algorithm to Predict Adjacent Musculoskeletal Infections in Pediatric Patients With Septic Arthritis.
    Clin Orthop Relat Res 2018 Jan;476(1):153-159
    B. D. WellingBaylor College of Medicine, Department of Orthopedic Surgery, Houston, TX, USA L. S. Haruno, S. B. RosenfeldTexas Children's Hospital, Division of Orthopedic Surgery, Houston, TX, USA.
    Background: Septic arthritis is frequently associated with adjacent infections including osteomyelitis and subperiosteal and intramuscular abscesses. While often clinically indiscernible from isolated septic arthritis, the diagnosis of adjacent infections is important in determining the need for additional surgical intervention. MRI has been used as the diagnostic gold standard for assessing adjacent infection. Read More

    Cost-effectiveness of Different Intra-articular Drug Injections on Wrist and/or Elbow Compromise in Patients With Established Rheumatoid Arthritis: Short-term Results of an Open Observational Evaluation.
    J Clin Rheumatol 2018 Feb 1. Epub 2018 Feb 1.
    From the Department of Clinical Immunology, Institute of Rheumatism & Immunity, PLA, Xijing Hospital, Fourth Military Medical University, Shaanxi Province, People's Republic of China.
    Background: Intra-articular (IA) injections are an integral part of the management of rheumatoid arthritis (RA). However, there are few reports regarding the association between drug effectiveness and cost.

    Objectives: The aim of this study was to assess the cost-effectiveness of various combinations of IA injections of betamethasone, hyaluronic acid (HA) or etanercept for oligoarthritis in RA. Read More

    Septic arthritis in children: diagnosis and treatment.
    Pediatric Health Med Ther 2017 18;8:65-68. Epub 2017 May 18.
    Department of Pediatric Orthopaedic Surgery.
    Acute septic arthritis in children is usually hematogenous. It is more common in boys, and it most often affects the large joints of the lower limb. Diagnosis is based on cultures obtained from the infected joint and is supported by C-reactive protein blood test or ultrasound imaging. Read More

    Anti-CCP-positive patients with RA have a higher 10-year probability of fracture evaluated by FRAX®: a registry study of RA with osteoporosis/fracture.
    Arthritis Res Ther 2018 Jan 30;20(1):16. Epub 2018 Jan 30.
    Kaohsiung Chang Gung Memorial Hospital, No. 123, Dapi Road, Niao-Song District, Kaohsiung, Taiwan, Republic of China.
    Background: Positive anticyclic citrullinated peptide (anti-CCP+) is associated with bone loss in patients with rheumatoid arthritis (RA). However, whether overall positivity or specific levels of anti-CCP are associated with prevalent fracture or a 10-year probability of fracture remains unclear.

    Methods: This interim analysis of an RA registry was conducted at Chang Gung Memorial Hospital in Kaohsiung (CGMHK) for RA-related osteoporosis/fracture. Read More

    NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice.
    Elife 2018 Jan 30;7. Epub 2018 Jan 30.
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, United States.
    Skeletal muscle frommice is characterized by increased Nox2 ROS, altered microtubule network, increased muscle stiffness, and decreased muscle/respiratory function. While microtubule de-tyrosination has been suggested to increase stiffness and Nox2 ROS production in isolated single myofibers, its role in altering tissue stiffness and muscle function has not been established. Because Nox2 ROS production is upregulated prior to microtubule network alterations and ROS affect microtubule formation, we investigated the role of Nox2 ROS in diaphragm tissue microtubule organization, stiffness and muscle/respiratory function. Read More

    Increased Frequency of Peripheral B and T Cells Expressing Granulocyte Monocyte Colony-Stimulating Factor in Rheumatoid Arthritis Patients.
    Front Immunol 2017 10;8:1967. Epub 2018 Jan 10.
    Joint Rheumatology Program, Clinical Immunology-Rheumatology Unit, 2nd Department of Medicine and Laboratory, School of Medicine, National and Kapodistrian University of Athens, Hippokration General Hospital, Athens, Greece.
    Objectives: Granulocyte monocyte colony-stimulating factor (GM-CSF) is currently considered a crucial inflammatory mediator and a novel therapeutic target in rheumatoid arthritis (RA), despite the fact that its precise cellular sources remain uncertain. We studied the expression of GM-CSF in peripheral lymphocytes from RA patients and its change with antirheumatic therapies.

    Methods: Intracellular GM-CSF expression was assessed by flow cytometry in stimulated peripheral B (CD19+) and T (CD3+) cells from RA patients ( = 40), disease ( = 31 including osteoarthritis = 15, psoriatic arthritis = 10, and systemic rheumatic diseases = 6) and healthy ( = 16) controls. Read More

    M1 and M2 Monocytes in Rheumatoid Arthritis: A Contribution of Imbalance of M1/M2 Monocytes to Osteoclastogenesis.
    Front Immunol 2017 8;8:1958. Epub 2018 Jan 8.
    Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
    Objectives: We investigated the relationships among M1 monocytes, M2 monocytes, osteoclast (OC) differentiation ability, and clinical characteristics in patients with rheumatoid arthritis (RA).

    Methods: Peripheral blood mononuclear cells (PBMCs) were isolated from RA patients and healthy donors, and we then investigated the number of M1 monocytes or M2 monocytes by fluorescence-activated cell sorting. We also obtained and cultured CD14-positive cells from PBMCs from RA patients and healthy donors to investigate OC differentiation. Read More

    A Phase 2a Randomized Study to Evaluate the Safety and Immunogenicity of the 1790GAHB Generalized Modules for Membrane Antigen Vaccine againstAdministered Intramuscularly to Adults from a Shigellosis-Endemic Country.
    Front Immunol 2017 22;8:1884. Epub 2017 Dec 22.
    GSK Vaccines Institute for Global Health, Siena, Italy.
    Shigellosis is a mild-to-severe diarrheal infection, caused by the genus, and is responsible for significant morbidity and mortality worldwide. We evaluated the safety and immunogenicity of an investigationalvaccine (1790GAHB) based on generalized modules for membrane antigens (GMMA) in Kenya, a-endemic country. This phase 2a, observer-blind, controlled randomized study (NCT02676895) enrolled 74 healthy adults aged 18-45 years, of whom 72 were vaccinated. Read More

    Meningococcal meningitis with neurological complications and meningococcemia due to serogroup W sequence type 11 complex.
    J Infect Chemother 2018 Jan 16. Epub 2018 Jan 16.
    Department of Bacteriology I, National Institute of Infectious Disease, 1-23-1 Toyama, Shinjyuku-ku, Tokyo 162-8640, Japan.
    Invasive meningococcal disease (IMD) caused by the serogroup W (MenW) sequence type-11 complex strain has recently emerged worldwide. Meningococcal infections due to this strain are associated with high case fatality and often atypical clinical manifestations. However, the annual IMD incidence was low, and MenW is rare in Japan. Read More

    Mast cells and pro-inflammatory cytokines roles in assessment of grape seeds extract anti-inflammatory activity in rat model of carrageenan-induced paw edema.
    Iran J Basic Med Sci 2018 Jan;21(1):97-107
    MVSc of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
    Objectives: Reactive oxygen species (ROS)-produced oxidative disorders were involved at the pathophysiology of many inflammatory processes via the generation of pro-inflammatory cytokines and antioxidant defense system suppression. Although herbal antioxidants as mono-therapy relief many inflammatory diseases including, autoimmunity rheumatoid arthritis, but as combination therapy with other proven anti-inflammatory drugs in order to decreasing their toxic impacts has not yet been studied clearly, especially against chemical substances that's induced local inflammation with characteristic edema.

    Materials And Methods: Grape seeds extract (GSE) at a concentration of 40 mg/kg B. Read More

    Application of the international league against rheumatism classification criteria for systemic juvenile idiopathic arthritis as a prognostic factor in patients with adults-onset Still's disease.
    Pediatr Rheumatol Online J 2018 Jan 25;16(1). Epub 2018 Jan 25.
    Department of Rheumatology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, South Korea.
    Background: Adult-onset Still's disease (AOSD) is an adult form of systemic juvenile idiopathic arthritis (JIA) that differs from the latter in its classification. This study evaluated the concordance between the International League Against Rheumatism (ILAR) criteria for systemic JIA and the Yamaguchi criteria and then compared their possible prognostic value in patients with AOSD.

    Methods: In a retrospective review of 169 adults with suspected AOSD, patients were classified according to the Yamaguchi or ILAR criteria. Read More

    A case report and literature review on fabella syndrome after high tibial osteotomy.
    Medicine (Baltimore) 2018 Jan;97(4):e9585
    Department of Orthopaedic Surgery, Kosin University Gospel Hospital, Busan, Korea.
    Rationale: The fabella is a normal structure, but is occasionally reported to cause posterior knee pain. The aim of this study was to present fabella syndrome after high tibial osteotomy.

    Patient Concerns: A 55-year-old female patient was admitted to the hospital due to about 1 year and 8 months of left knee pain. Read More

    Elimination of stem-like cancer cell side-population by auranofin through modulation of ROS and glycolysis.
    Cell Death Dis 2018 Jan 24;9(2):89. Epub 2018 Jan 24.
    Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, Guangdong, China.
    Cancer side-population (SP) represents a sub-population of stem-like cancer cells that have an important role in drug resistance due to their high expression of the ATP-binding cassette transporter ABCG2 involved in drug export. Auranofin (AF), a clinical drug of gold complex that is used in treatment of rheumatoid arthritis, has been reported inducing tumor antiproliferation. However, whether AF can impact SP cells remains unclear. Read More

    [A case of axial spondyloarthritis acute onset as opportunity tonsil foci infection].
    Nihon Rinsho Meneki Gakkai Kaishi 2017 ;40(6):460-466
    Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine.
      A 49-year-old female with a chief complaints of arthralgia, and a medical history is Hashimoto's disease presented to us. She had been previously treated for Sjögren's syndrome at our hospital. She had anterior chest and polyarticular pain. Read More

    Population Pharmacokinetics of the TNF-α and IL-17A Dual-Variable Domain Antibody ABT-122 in Healthy Volunteers and Subjects With Psoriatic or Rheumatoid Arthritis: Analysis of Phase 1 and 2 Clinical Trials.
    J Clin Pharmacol 2018 Jan 24. Epub 2018 Jan 24.
    Clinical Pharmacology and Pharmacometrics, AbbVie, North Chicago, IL, USA.
    ABT-122 is an IgG1 dual-variable domain immunoglobulin that specifically blocks TNF-α and IL-17A. This work characterized ABT-122 pharmacokinetics using nonlinear mixed-effects modeling and ABT-122 serum concentrations from 72 healthy subjects, 196 subjects with rheumatoid arthritis (RA), and 144 subjects with psoriatic arthritis (PsA) enrolled in 4 phase 1 and 2 phase 2 studies (0.1-10 mg/kg intravenously and 0. Read More

    Correlations between CXCL13, IL-24 genes and wrist arthritis.
    Eur Rev Med Pharmacol Sci 2018 Jan;22(1):25-30
    Department of Medicine, Soochow University, Suzhou, China.
    Objective: To investigate the relationship between B lymphocyte chemokine 1 (CXCL13) and interleukin-24 (IL-24) gene and wrist arthritis.

    Patients And Methods: A total of 122 cases of patients with wrist arthritis treated in our hospital from May 2013 to April 2016 were randomly selected as wrist arthritis group, while 120 normal subjects were selected as normal control group. Venous blood was collected from all patients in normal control group and wrist arthritis group, respectively. Read More

    Mavrilimumab, a fully human granulocyte-macrophage colony-stimulating factor receptor α monoclonal antibody: long-term safety and efficacy in patients with rheumatoid arthritis.
    Arthritis Rheumatol 2018 Jan 23. Epub 2018 Jan 23.
    Division of Rheumatology, Brigham and Women's Hospital, Boston, MA, USA.
    Objective: Mavrilimumab, a human monoclonal antibody, targets granulocyte-macrophage colony-stimulating factor receptor alpha. We report mavrilimumab long-term safety and efficacy in rheumatoid arthritis patients in two phase IIb studies (1071, 1107) and open-label extension (OLE; NCT01712399).

    Methods: In 1071, patients with disease-modifying antirheumatic drug (DMARD)-inadequate responses received mavrilimumab 30, 100, 150 mg, or placebo every other week (eow), plus methotrexate. Read More

    Serum Protein-Glycosylation Changes with Rheumatoid Arthritis Disease Activity during and after Pregnancy.
    Front Med (Lausanne) 2017 8;4:241. Epub 2018 Jan 8.
    Department of Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands.
    Symptoms of rheumatoid arthritis (RA) improve during pregnancy, a phenomenon that was found to be associated with-glycosylation changes of immunoglobulin G. Recent advances in high-throughput glycosylation analysis allow the assessment of the-glycome of human sera as well. The aim of this study was to identify new protein-glycosylation properties that associate with changes in RA disease activity during and after pregnancy. Read More

    Practice and consensus-based strategies in diagnosing and managing systemic juvenile idiopathic arthritis in Germany.
    Pediatr Rheumatol Online J 2018 Jan 22;16(1). Epub 2018 Jan 22.
    Department of Pediatric Rheumatology and Immunology, University Hospital Münster, Münster, Albert-Schweitzer-Campus 1, Building W30, 48149, Münster, Germany.
    Background: Systemic juvenile idiopathic arthritis (SJIA) is an autoinflammatory disease associated with chronic arthritis. Early diagnosis and effective therapy of SJIA is desirable, so that complications are avoided. The PRO-KIND initiative of the German Society for Pediatric Rheumatology (GKJR) aims to define consensus-based strategies to harmonize diagnostic and therapeutic approaches in Germany. Read More

    [Flipping moxibustion ofmedicine combined with western medication for rheumatoid arthritis with cold dampnesssyndrome].
    Zhongguo Zhen Jiu 2017 Oct;37(10):1047-51
    College of TCM, Ningxia Medical University, Yinchuan 750004, China.
    Objective: To compare the effects of flipping moxibustion ofmedicine combined with western medication and simple western medication for rheumatoid arthritis with cold dampnesssyndrome.

    Methods: Eighty patients were randomly assigned into an observation group and a control group, 40 cases in each group. Oral methotrexate (1 time a week) and sulfasalazine (twice a day except the day for methotrexate) were used in the two groups. Read More

    Long-Term Efficacy of Rehabilitation Following Arthroscopic Synovectomy in Patients With Rheumatoid Arthritis Treated With Biologic Agents.
    Ann Rehabil Med 2017 Dec 28;41(6):998-1004. Epub 2017 Dec 28.
    Department of Rehabilitation, Tokyo Women's Medical University, Medical Center East, Tokyo, Japan.
    Objective: To investigate the long-term efficacy of rehabilitation following arthroscopic synovectomy in patients with rheumatoid arthritis treated with biologic agents.

    Methods: Arthroscopic synovectomy was performed in 29 joints of 17 patients, which were divided into two groups. Group 1 included arthroscopic synovectomy plus rehabilitation for 19 joints in 10 patients, and group 2 included arthroscopic synovectomy without rehabilitation for 10 joints in 7 patients. Read More

    The anti-inflammatory effects of statins on patients with rheumatoid arthritis: A systemic review and meta-analysis of 15 randomized controlled trials.
    Autoimmun Rev 2018 Jan 17. Epub 2018 Jan 17.
    Tianjin Hospital, No. 406 Jiefang South Rd, Hexi District, Tianjin 300211, China. Electronic address:
    Background: Over the past several years, numerous studies investigated the anti-inflammatory effects of statin on patients with RA. However, the findings of the individual studies were often inconsistent or conflicting.

    Materials And Methods: The Pubmed, Web of Science, Embase, Cochrane Library and CNKI literature databases were searched in order to identify randomized controlled clinical trials where the association between the anti-inflammatory effect of statin and RA was investigated. Read More

    Inflammatory back pain and associated disease conditions among patients with chronic low back pain in Bangladesh.
    Int J Rheum Dis 2018 Jan 18. Epub 2018 Jan 18.
    Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
    Aim: Inflammatory back pain (IBP) is the earliest symptom of axial and other forms of spondyloarthritis (SpA). However, there are no published data on prevalence of IBP among patients suffering from chronic low back pain (CLBP) in Bangladesh. In this study, we estimated the prevalence of IBP and the subtypes of SpA in a tertiary hospital in Bangladesh. Read More

    Early and sustained efficacy with apremilast monotherapy in biological-naïve patients with psoriatic arthritis: a phase IIIB, randomised controlled trial (ACTIVE).
    Ann Rheum Dis 2018 Jan 17. Epub 2018 Jan 17.
    West Tennessee Research Institute, Jackson, Tennessee, USA.
    Objective: Evaluate apremilast efficacy across various psoriatic arthritis (PsA) manifestations beginning at week 2 in biological-naïve patients with PsA.

    Methods: Patients were randomised (1:1) to apremilast 30 mg twice daily or placebo. At week 16, patients whose swollen and tender joint counts had not improved by ≥10% were eligible for early escape. Read More

    Effectiveness of early adalimumab therapy in psoriatic arthritis patients from Reuma.pt - EARLY PsA.
    Acta Reumatol Port 2017 Oct-Dec;42(4):287-299
    Hospital Garcia de Orta.
    Objective To compare outcomes in psoriatic arthritis (PsA) patients initiating adalimumab (ADA), with short- and long-term disease duration and to evaluate the potential effect of concomitant conventional synthetic disease-modifying antirheumatic drugs (csDMARD) or glucocorticoids. Methods Analyses included adult PsA patients registered in the Rheumatic Diseases Portuguese Register (Reuma.pt) between June 2008-June 2016 who received ADA for ≥3 months. Read More

    The polymethoxy flavonoid sudachitin suppresses inflammatory bone destruction by directly inhibiting osteoclastogenesis due to reduced ROS production and MAPK activation in osteoclast precursors.
    PLoS One 2018 17;13(1):e0191192. Epub 2018 Jan 17.
    Division of Oral Anatomy, Meikai University School of Dentistry, Sakado, Saitama, Japan.
    Inflammatory bone diseases, including rheumatoid arthritis, periodontitis and peri-implantitis, are associated not only with the production of inflammatory cytokines but also with local oxidative status, which is defined by intracellular reactive oxygen species (ROS). Osteoclast differentiation has been reported to be related to increased intracellular ROS levels in osteoclast lineage cells. Sudachitin, which is a polymethoxyflavone derived from Citrus sudachi, possesses antioxidant properties and regulates various functions in mammalian cells. Read More

    Rheumatoid arthritis and periodontal disease: What are the similarities and differences?
    Int J Rheum Dis 2017 Dec 9;20(12):1887-1901. Epub 2018 Jan 9.
    Center of Integrative Research, The First Hospital of Qiqihaer City, Qiqihaer, Heilongjiang, China.
    Rheumatoid arthritis (RA) and periodontal disease (PD) are chronic inflammatory diseases that share similar osteoclasia, human leukocyte antigen-DR4 allelic genes and immunological profile, and characteristic cytokines. Smoking can contribute to more severe RA and PD; secretion of pro-inflammatory mediators destroys the soft synovial membrane and periodontium, respectively. Anti-citrullinated protein antibodies and anti-α-enolase antibody are characteristic of these two diseases. Read More

    Comparative Efficacy of Tumor Necrosis Factor-α Inhibitors in Ankylosing Spondylitis: A Systematic Review and Bayesian Network Metaanalysis.
    J Rheumatol 2018 Jan 15. Epub 2018 Jan 15.
    From Columbia University Medical Center, New York; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland, USA. Funding provided by Intramural Research Program, NIAMS, and NIH. RW is a recipient of the Rheumatology Research Foundation Scientist Development Award. The content is the responsibility of the authors and does not necessarily represent the official views of the NIH. Portions of the data were obtained from the Pfizer Clinical Data Set through a data-use agreement, and from Amgen Inc. through a data-sharing agreement. In addition, the study, carried out under YODA Project #2014-0291, used data obtained from the Yale University Open Data Access Project, which has an agreement with Janssen Research & Development LLC. The interpretation and reporting of research using these data are solely the responsibility of the authors and do not necessarily represent the official views of the Yale University Open Data Access Project or Janssen Research & Development LLC. Amgen Inc., Pfizer Inc., and the Yale Open Data Access Project were provided copies of the manuscript before submission. R. Wang, MD, MHS, Division of Rheumatology, Columbia University Medical Center; A. Dasgupta, PhD, Intramural Research Program, NIAMS, NIH; M.M. Ward, MD, MPH, Intramural Research Program, NIAMS. Address correspondence to Dr. R. Wang, MD, MHS, Division of Rheumatology, Columbia University Medical Center, P & S 10-445, 630 W. 168th St., New York, New York 10032, USA. E-mail: Accepted for publication September 29, 2017.
    Objective: To compare the efficacy of 6 tumor necrosis factor-α inhibitors (TNFi) in treatment of ankylosing spondylitis (AS) at 12 weeks and 24 weeks.

    Methods: We performed a systematic literature review of randomized controlled trials of TNFi in patients with active AS. We included trials that reported efficacy at 10 to 14 weeks (12-week analysis) and at 24 to 30 weeks (24-week analysis). Read More

    Role of human microbiome and selected bacterial infections in the pathogenesis of rheumatoid arthritis.
    Reumatologia 2017 28;55(5):242-250. Epub 2017 Oct 28.
    Chair and Clinic of Rheumatology and Internal Diseases, Poznan University of Medical Sciences, Poznan.
    Microorganisms inhabiting human body form a complex ecosystem. The mutual influence of the microbiome and the immune system of the host constitute the basis for numerous diseases, e.g. Read More

    Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease.
    J Alzheimers Dis 2018 ;61(3):843-866
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
    The purpose of our article is to assess the current understanding of Indian spice, curcumin, against amyloid-β (Aβ)-induced toxicity in Alzheimer's disease (AD) pathogenesis. Natural products, such as ginger, curcumin, and gingko biloba have been used as diets and dietary supplements to treat human diseases, including cancer, cardiovascular, respiratory, infectious, diabetes, obesity, metabolic syndromes, and neurological disorders. Products derived from plants are known to have protective effects, including anti-inflammatory, antioxidant, anti-arthritis, pro-healing, and boosting memory cognitive functions. Read More

    Cigarette smoking and hip volumetric bone mineral density and cortical volume loss in older adults: The AGES-Reykjavik study.
    Bone 2018 Mar 10;108:186-192. Epub 2018 Jan 10.
    National Institute on Aging, Intramural Research Program, Laboratory of Epidemiology and Population Sciences, Bethesda, MD, USA.
    This study aimed to explore the relationships of several indicators of cigarette smoking habits (smoking status, pack-years, age at smoking initiation and smoking cessation) with quantitative computed tomographic (QCT)-derived proximal femur bone measures (trabecular vBMD, integral vBMD and the ratio of cortical to total tissue volume (cvol/ivol)) and with subsequent change in these measures over the next five years. A total of 2673 older adults (55.9% women), aged 66-92 years at baseline from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, who had two QCT scans of the hip were studied. Read More

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