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    Anti-drug antibodies in Colombian patients with rheumatoid arthritis treated with Enbrel vs Etanar - Preliminary report.
    J Immunotoxicol 2017 Dec;14(1):103-108
    a Pharmacy Department, Immunotoxicology Research Group , National University of Colombia, and Foundation Institute of Immunology of Colombia , Bogota , Colombia.
    The present study was undertaken to detect antibodies against etanercept (ETN) in a group of Colombian patients with rheumatoid arthritis (RA) and being treated with Enbrel(®) vs. Etanar(®). From these patients with RA, clinical and laboratory data were collected and serum taken for anti-drug antibody (ADAb) analysis. Read More

    Photobiomodulation therapy associated with treadmill training in the oxidative stress in a collagen-induced arthritis model.
    Lasers Med Sci 2017 Apr 21. Epub 2017 Apr 21.
    Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho, (UNINOVE), Rua Vergueiro 235, São Paulo, SP, Brazil.
    Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by chronic and systemic inflammation, which leads to the destruction of the cartilage and bone and affects tissues in multiple joints. Oxidative stress has been implicated with regards to involvement in various disease conditions, such as diabetes mellitus and neurodegenerative, respiratory, cardiovascular, and RA diseases. In vivo experimental studies using photobiomodulation therapy (PBMT) have shown positive effects in reducing lipid peroxidation and in increasing antioxidant activity. Read More

    Shigella Draft Genome Sequences: Resources for Food Safety and Public Health.
    Genome Announc 2017 Apr 20;5(16). Epub 2017 Apr 20.
    School of Veterinary Medicine, 100K Pathogen Genome Project, UC Davis, Davis, California, USA
    Shigella is a major foodborne pathogen that infects humans and nonhuman primates and is the major cause of dysentery and reactive arthritis worldwide. This is the initial public release of 16 Shigella genome sequences from four species sequenced as part of the 100K Pathogen Genome Project. Read More

    Calprotectin levels in rheumatoid arthritis and their correlation with disease activity: a meta-analysis.
    Postgrad Med 2017 Apr 24:1-7. Epub 2017 Apr 24.
    a Department of Rheumatology , Hanyang University Hospital for Rheumatic Diseases , Seoul , Korea.
    Objective: We evaluated the relationship between calprotectin levels and rheumatoid arthritis (RA), and the correlation between plasma/serum calprotectin and RA activity.

    Methods: We searched PUBMED, EMBASE, and Cochrane databases and performed meta-analyses comparing plasma/serum or synovial fluid calprotectin levels in RA patients and controls, and correlation coefficients between calprotectin levels and disease activity for 28 joints (DAS28) as well as C-reactive protein (CRP) in RA patients.

    Results: Sixteen studies including 849 RA patients and 266 controls were available for meta-analysis. Read More

    Takayasu Arteritis and Spondyloarthritis: Coincidence or Association? A Study of 14 Cases.
    J Rheumatol 2017 Apr 15. Epub 2017 Apr 15.
    From the Rheumatology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Paris-Sud, Université Paris-Sud, Le Kremlin Bicêtre; INSERM UMR-S 1136, Hôpital Pitié-Salpêtrière; Rheumatology A Department, Hôpital Cochin, University Paris Descartes; Rheumatology, Groupe Hospitalier Diaconesses Croix Saint Simon; Rheumatology Department B, Hôpital Cochin, Paris; Internal Medicine, Centre Hospitalier Universitaire (CHU) Timone, Aix Marseille Université, Marseille; Rheumatology, CHU H. Mondor, Créteil; Rheumatology, Centre hospitalier Le Mans; Rheumatology, Hôpital Salengro, Lille; Rheumatology, GH Pellegrin, Bordeaux; Rheumatology, CHU Gabriel Montpied, Clermont Ferrand, France. E. Rivière, MD, Rheumatology, AP-HP, Hôpitaux Universitaires Paris- Sud, Université Paris-Sud; L. Arnaud, MD, PhD, INSERM UMR-S 1136, Hôpital Pitié-Salpêtrière; Rheumatology A Department, Hôpital Cochin, University Paris Descartes; M. Ebbo, MD, Internal Medicine, CHU Timone, Aix Marseille Université; Y. Allanore, MD, PhD, Rheumatology A Department, Hôpital Cochin, University Paris Descartes; P. Claudepierre, MD, Rheumatology, CHU H. Mondor; E. Dernis, MD, Rheumatology, Centre hospitalier Le Mans; J.M. Ziza, MD, Rheumatology, Groupe Hospitalier Diaconesses Croix Saint Simon; C. Miceli-Richard, MD, PhD, Rheumatology, Department B, Hôpital Cochin; P. Philippe, MD, Rheumatology, Hôpital Salengro; C. Richez, MD, PhD, Rheumatology, GH Pellegrin; M. Soubrier, MD, PhD, Rheumatology, CHU Gabriel Montpied; R. Belkhir, MD, Rheumatology, AP-HP, Hôpitaux Universitaires Paris-Sud, Université Paris-Sud; R. Seror, MD, PhD, Rheumatology, AP-HP, Hôpitaux Universitaires Paris-Sud, Université Paris-Sud; X. Mariette, MD, PhD, Rheumatology, AP-HP, Hôpitaux Universitaires Paris-Sud, Université Paris-Sud; S. Pavy, MD, Rheumatology, AP-HP, Hôpitaux Universitaires Paris-Sud, Université Paris-Sud. Address correspondence to Dr. S. Pavy, Rheumatology, Hôpitaux Universitaires Paris-Sud, Hôpital Bicêtre, 78 rue du Général Leclerc, 94270 Le Kremlin Bicêtre, France. E-mail: Accepted for publication February 23, 2017.
    Objective: Spondyloarthritis (SpA) and Takayasu arteritis (TA) are 2 chronic inflammatory diseases; their coexistence in a single patient is uncommon. The aims of our study were to describe clinical features of patients having SpA associated with TA and to identify some characteristics of the types of patients with SpA associated with TA. We also analyzed treatments used in this context. Read More

    The correlation of serum bilirubin levels with disease activity in patients with rheumatoid arthritis.
    Clin Chim Acta 2017 Apr 11;469:187-190. Epub 2017 Apr 11.
    Department of Laboratory Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, China.
    Background: We investigated the relationship between serum bilirubin and disease activity in patients with rheumatoid arthritis (RA).

    Methods: We included a total of 173 consecutive RA patients without steroid treatment and 346 healthy subjects; the disease activity score in 28 joints (DAS28) was used to assess disease activity in patients with RA.

    Results: Serum bilirubin concentrations were significantly lower in RA patients than in controls. Read More

    An open randomized active-controlled clinical trial with low-dose SKA cytokines versus DMARDs evaluating low disease activity maintenance in patients with rheumatoid arthritis.
    Drug Des Devel Ther 2017 29;11:985-994. Epub 2017 Mar 29.
    Operative Unit of Rheumatology.
    Background: Biologic agents are currently the strongest immunosuppressive drugs able to induce remission in rheumatoid arthritis (RA). One of the objectives of the medical scientific community now is how to maintain remission or low disease activity (LDA). The aim of this trial is to evaluate the contribution of low-dose sequential kinetic activation (SKA) IL-4, IL-10, and anti-IL-1 antibodies (10 fg/mL) in patients affected by RA in maintaining LDA or remission obtained after biological therapy. Read More

    Lectin pathway factors in patients suffering from juvenile idiopathic arthritis.
    Immunol Cell Biol 2017 Apr 13. Epub 2017 Apr 13.
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland.
    Both complement activation and certain infections (including those with Yersinia sp.) may contribute to the pathogenesis of juvenile idiopathic arthritis (JIA). We investigated factors specific for the lectin pathway of complement: mannose-binding lectin (MBL), ficolins and associated serine protease-2 (MASP-2), in 144 patients and 98 controls. Read More

    Is the treatment with biological or non-biological DMARDS a modifier of periodontal condition in patients with rheumatoid arthritis?
    Curr Rheumatol Rev 2017 Apr 7. Epub 2017 Apr 7.
    Hospital Militar Central - Deparment of Rheumatology and Immunology Bogota, Bogota,ColombiaDeparment of Rheumatology and Immunology Bogota, Bogota,ColombiaUniversidad Militar Nueva Granada - Faculty of Medicine Bogota, Bogota. Colombia.
    Background And Objective: Experimental models suggest the use of different therapy protocols in rheumatoid arthritis (RA) as modulators on periodontal condition. This study evaluated the effects of conventional drug treatment and anti-TNF therapy in patients with RA on microbiological and periodontal condition, establishing the association of markers of periodontal infection with indexes of rheumatic activity.

    Materials And Methods: One hundred seventy nine individuals with RA were evaluated (62 with anti-TNF-α and 115 with only DMARDs). Read More

    Profile of patients with spondyloarthritis in Morocco.
    Curr Rheumatol Rev 2017 Apr 6. Epub 2017 Apr 6.
    Hospital university center Hassan II, sidi mohammed Ben Abdallah university. Morocco.
    Objectives: to describe the characteristics of our population with spondyloarthritis: diagnostic time, clinical manifestations and laboratory investigations, activity, functional impairment, severity and therapeutic management. The authors were also interested to investigate factors associated with severe disease.

    Methods: A retrospective observational study, conducted in the rheumatology department at university hospital center Hassan II of Fez, analyzing the records of patients diagnosed as spondylarthritis during the period extending from January 2009 to June 2014. Read More

    The impact of obesity and adiposity on inflammatory markers in patients with rheumatoid arthritis.
    Arthritis Care Res (Hoboken) 2017 Apr 10. Epub 2017 Apr 10.
    Background: C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are important disease activity biomarkers in rheumatoid arthritis (RA). This study aimed to determine to what extent obesity biases these biomarkers.

    Methods: Body mass index (BMI) associations with CRP and ESR were assessed in two RA cohorts - 1) the cross-sectional Body Composition (BC) cohort (N = 451) including whole-body DXA measures of fat mass index, and 2) the longitudinal Veterans Affairs Rheumatoid Arthritis (VARA) registry (N = 1652), using multivariable models stratified by sex. Read More

    IL-17 and IFN-γ producing NK and γδ-T cells are preferentially expanded in synovial fluid of patients with reactive arthritis and undifferentiated spondyloarthritis.
    Clin Immunol 2017 Apr 5. Epub 2017 Apr 5.
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India. Electronic address:
    IL-17/1L-23 axis is important in the pathogenesis of spondyloarthropathy. Besides Th17 cells, innate cells also produce IL-17. We studied the frequencies of natural killer (NK) (total, CD56(bright), CD56(dim), perforin+and granzyme+), NK-T, and γδ-T cells. Read More

    Diagnostic value of a 3-day course of prednisolone in patients with possible rheumatoid arthritis - the TryCort study.
    Arthritis Res Ther 2017 Apr 7;19(1):73. Epub 2017 Apr 7.
    Rheumazentrum Ruhrgebiet, Claudiusstraße 45, 44649, Herne, Germany.
    Background: In patients with tender and swollen finger joints, the differential diagnosis between rheumatoid arthritis (RA) and osteoarthritis (OA) of the hands can be initially difficult. This prospective study (the TryCort study) was performed to study the diagnostic value of prednisolone in differentiating between RA and hand OA. We present the results of this potentially diagnostic test in patients with possible RA in daily clinical practice by demonstrating the results of a pilot and a validation part of this 'prednisolone test' (pred-test). Read More

    Adipose Tissue Macrophages in Rheumatoid Arthritis: Prevalence, Disease Related Indicators, and Associations with Cardiometabolic Risk Factors.
    Arthritis Care Res (Hoboken) 2017 Apr 7. Epub 2017 Apr 7.
    Divisions of Rheumatology, Columbia University College of Physicians & Surgeons, New York, New York, USA.
    Objective Adipose tissue macrophages (ATMs) are a potent source of inflammatory cytokines with profound effects on adipose tissue function, yet their potential role in rheumatoid arthritis (RA) pathobiology is largely unstudied. Methods Periumbilical subcutaneous adipose tissue was obtained from 36 RA patients and 22 non-RA controls frequency matched on demographics and BMI. Samples were stained for the macrophage marker CD68 and the average proportion of ATMs, crown-like structures (CLSs: peri-adipocyte aggregates of three or more ATMs), and fibrosis were compared between groups. Read More

    The ratio of nurse consultation and physician efficiency index of senior rheumatologists is significantly higher than junior physicians in rheumatology residency training: A new efficiency measure in a cohort, exploratory study.
    Medicine (Baltimore) 2017 Apr;96(14):e6601
    aDepartment of Rheumatology, Odense University Hospital, Svendborg Hospital, Svendborg bDepartment of Economy, Aarhus University, Aarhus cUniversity of Southern Denmark, Odense dDanbio, Copenhagen, Denmark.
    To elucidate the difference between ratios of nurse consultation sought by senior rheumatologists and junior physicians in rheumatology residency training, and also to evaluate physician efficiency index respecting patients with rheumatoid arthritis (RA).Data regarding outpatient visits for RA patients between November 2013 and 2015 were extracted. The mean interval (day) between consultations, the nurse/physician visits ratio, and physician efficiency index (nurse/physician visits ratio × mean interval) for each senior and junior physicians were calculated. Read More

    Musculoskeletal manifestations of Ebola virus.
    Rheumatology (Oxford) 2017 Apr 4. Epub 2017 Apr 4.
    Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK.
    The 2014 West African Ebola virus disease outbreak shocked the world as it swept through the region leaving Guinea, Liberia and Sierra Leone struggling to gain control. As the largest Ebola virus disease outbreak to date, there are more survivors in its wake than ever before, with a spectrum of health problems requiring management. Here we review various musculoskeletal manifestations of the virus that can occur both during and after the infection, and consider possible pathogenesis. Read More

    Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression.
    J Neuroinflammation 2017 Apr 4;14(1):74. Epub 2017 Apr 4.
    Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, 211166, People's Republic of China.
    Background: Gout is one of the common inflammatory arthritis which affects many people for inflicting unbearable pain. Macrophage-mediated inflammation plays an important role in gout. The uptake of monosodium urate (MSU) crystals by macrophages can lead to activation of NOD-like receptors containing a PYD 3 (NLRP3) inflammasome, thus accelerating interleukin (IL)-1β production. Read More

    Polymorphisms in the promoter region of iNOS predispose to rheumatoid arthritis in south Indian Tamils.
    Int J Immunogenet 2017 Apr 4. Epub 2017 Apr 4.
    INSERM, UMRS, U1160, Saint Louis Hospital, Paris, France.
    Nitric oxide synthase (NOS) catalyses the production of nitric oxide (NO) from L-Arginine, which participates in diverse biological processes including inflammation and apoptosis. Macrophages, chondrocytes, osteoblasts and osteoclasts express inducible NOS (iNOS) at the site of synovial inflammation. NO produced at the inflamed joint may contribute to peri-articular bone loss, mediate apoptosis and regulate Th1/Th2 balance in rheumatoid arthritis (RA). Read More

    Real-life effectiveness of Golimumab in biologic-naïve patients with rheumatoid arthritis - data from the Rheumatic Diseases Portuguese Register (Reuma.pt).
    Acta Reumatol Port 2017 Feb 18. Epub 2017 Feb 18.
    Faculdade de Ciências Médicas da Universidade Nova de Lisboa.
    Objectives: To assess the effectiveness of subcutaneous Golimumab 50 mg/monthly combined with methotrexate (SC GLM + MTX) over 52 weeks of treatment, in biologic-naïve RA patients, in a multicentre nationwide cohort from the Rheumatic Diseases Portuguese Register (Reuma.pt).

    Methods: Data for this observational study was collected from March 2011 to August 2015. Read More

    Dietary Intake of Polyunsaturated Fatty Acids and Pain in spite of Inflammatory Control among Methotrexate Treated Early Rheumatoid Arthritis Patients.
    Arthritis Care Res (Hoboken) 2017 Mar 28. Epub 2017 Mar 28.
    Unit of Rheumatology, Department of Medicine Solna, Karolinska Institutet, SWEDEN.
    Objective To investigate potential associations between dietary intake of polyunsaturated fatty acids (PUFA) and pain patterns in early rheumatoid arthritis (RA) patients after three months of methotrexate (MTX) treatment. Methods We included 591 early RA patients with MTX monotherapy from a population based prospective case-control study, the Epidemiological Investigation of Rheumatoid Arthritis (EIRA). Dietary data on PUFA (food frequency questionnaires) were linked with data on unacceptable pain (visual analogue scale (VAS) >40mm), non-inflammatory/refractory pain (VAS >40mm and C-reactive protein (CRP) <10mg/L) and inflammatory pain (VAS >40mm and CRP >10mg/L) after three months. Read More

    Janus kinase inhibitors prevent migration of rheumatoid arthritis neutrophils towards interleukin-8, but do not inhibit priming of the respiratory burst or reactive oxygen species production.
    Clin Exp Immunol 2017 Apr 2. Epub 2017 Apr 2.
    Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
    Neutrophils play a crucial role in the pathophysiology of rheumatoid arthritis (RA) via the release of reactive oxygen species (ROS), proteases and cytokines. Orally active Janus kinase (JAK) inhibitors (JAKi), e.g. Read More

    Serum levels of matrix metalloproteinase-3 and autoantibodies related to rheumatoid arthritis in the general Japanese population and their association with osteoporosis and osteoarthritis: the ROAD study.
    J Bone Miner Metab 2017 Apr 1. Epub 2017 Apr 1.
    Department of Joint Disease Research, 22nd Century Medical and Research Center, Faculty of Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan.
    To purpose of this study was to reveal the mean levels and positive proportion of serological markers related to rheumatoid arthritis, and clarify their relationship with osteoporosis and hand osteoarthritis (OA). A total of 1546 participants from the third survey of the research on osteoarthritis/osteoporosis against disability study were enrolled in the current study. Using participant blood samples, the levels of anti-cyclic citrullinated protein (CCP) antibody, rheumatoid factor (RF), matrix metalloproteinase-3 (MMP-3), C-reactive protein (CRP), and high-sensitivity CRP (hsCRP) were measured. Read More

    The Relationship Between Cardiac Conduction Times, Cardiovascular Risk Factors, and Inflammation in Patients with Early Arthritis.
    J Rheumatol 2017 Apr 1. Epub 2017 Apr 1.
    From the Department of Rheumatology, Amsterdam Rheumatology and Immunology Center | Reade; Department of Cardiology, VUmc; Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, VUmc; Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, AMC, Amsterdam, the Netherlands. S.A. Turk, MD, Department of Rheumatology, Amsterdam Rheumatology and Immunology Center | Reade; S.C. Heslinga, MD, Department of Rheumatology, Amsterdam Rheumatology and Immunology Center | Reade; J. Dekker, MD, Department of Cardiology, VUmc; L. Britsemmer, Department of Rheumatology, Amsterdam Rheumatology and Immunology Center | Reade; V. van der Lugt, Department of Rheumatology, Amsterdam Rheumatology and Immunology Center | Reade; W.F. Lems, Professor, MD, Department of Rheumatology, Amsterdam Rheumatology and Immunology Center | Reade, and Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, VUmc; D. van Schaardenburg, Professor, MD, Department of Rheumatology, Amsterdam Rheumatology and Immunology Center | Reade, and Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, AMC; M.T. Nurmohamed, Professor, MD, Department of Rheumatology, Amsterdam Rheumatology and Immunology Center | Reade, and Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, VUmc. Address correspondence to Dr. S.A. Turk, Department of Rheumatology, Amsterdam Rheumatology and Immunology Center | Reade, PO Box 58271, 1040 HG Amsterdam, the Netherlands. E-mail: Accepted for publication January 25, 2017.
    Objective: To investigate the prevalence of conduction disorders in patients with early arthritis and the relationship with inflammation and traditional cardiovascular (CV) risk factors.

    Methods: Patients with rheumatoid arthritis (RA) have a 2-fold higher risk of sudden cardiac death, possibly owing to conduction disorders. This increased risk might already be present at the clinical onset of arthritis. Read More

    Adalimumab with Methotrexate in Treatment-Naïve Japanese Patients with Rheumatoid Arthritis at Risk of Progressive Structural Joint Damage: A Postmarketing Observational Study.
    Rheumatol Ther 2017 Mar 31. Epub 2017 Mar 31.
    AbbVie GK, Tokyo, Japan.
    Introduction: The objective of this study was to evaluate the real-world safety and effectiveness of adalimumab with methotrexate (MTX) in disease-modifying antirheumatic drug (DMARD)- and biologic-naïve Japanese patients with rheumatoid arthritis (RA) at risk of progressive structural joint damage.

    Methods: This multicenter, prospective, observational, postmarketing surveillance study was conducted between February 2013 and April 2015 at 84 centers in Japan. Patients with RA at risk of progressive structural joint damage were enrolled and initiated treatment with adalimumab and MTX. Read More

    Immunometabolism in early and late stages of rheumatoid arthritis.
    Nat Rev Rheumatol 2017 May 31;13(5):291-301. Epub 2017 Mar 31.
    Department of Medicine, Stanford University School of Medicine, 269 Campus Drive West, Stanford, California 94305, USA.
    One of the fundamental traits of immune cells in rheumatoid arthritis (RA) is their ability to proliferate, a property shared with the joint-resident cells that form the synovial pannus. The building of biomass imposes high demands for energy and biosynthetic precursors, implicating metabolic control as a basic disease mechanism. During preclinical RA, when autoreactive T cells expand and immunological tolerance is broken, the main sites of disease are the secondary lymphoid tissues. Read More

    Chlamydia trachomatis Genital Infections.
    Microb Cell 2016 Sep 5;3(9):390-403. Epub 2016 Sep 5.
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
    Etiology, transmission and protection: Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infection (STI) globally. However, C. trachomatis also causes trachoma in endemic areas, mostly Africa and the Middle East, and is a leading cause of preventable blindness worldwide. Read More

    Minimal disease activity and impact of disease in psoriatic arthritis: a Spanish cross-sectional multicenter study.
    Arthritis Res Ther 2017 Mar 29;19(1):72. Epub 2017 Mar 29.
    Medical Department, Pfizer, Avenida de Europa, 20 B, 28108, Alcobendas, Madrid, Spain.
    Background: Patients with psoriatic arthritis (PsA) experience functional impairment and reduced quality of life, and thus patient global assessment in PsA is explained mainly by the physical, but also by the psychological, aspect of the disease. To assess the prevalence of minimal disease activity (MDA) in Spanish patients with PsA, we examined their characteristics and the association between MDA and the impact of the disease as assessed by the PsA Impact of Disease (PsAID) questionnaire.

    Methods: A cross-sectional multicenter study was carried out in patients who fulfilled the Classification for Psoriatic Arthritis (CASPAR) criteria with at least 1 year of disease duration, and who were treated with biological or conventional synthetic (cs) disease-modifying anti-rheumatic drugs (DMARDs) according to routine clinical practice in Spain. Read More

    Long non-coding RNA ASncmtRNA-2 is upregulated in diabetic kidneys and high glucose-treated mesangial cells.
    Exp Ther Med 2017 Feb 5;13(2):581-587. Epub 2017 Jan 5.
    Department of Endocrinology, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China.
    Diabetic nephropathy (DN) is one of the most frequent complications associated with type I and II diabetes mellitus. Kidneys from patients with DN are characterized by mesangial matrix expansion and increased thickness of the glomerular basement membrane, which are induced by reactive oxygen species (ROS) production. Previous studies have been conducted to investigate this; however, the detailed mechanism of DN progression remains to be elucidated. Read More

    Clinical characteristics associated with occurrence and poor prognosis of interstitial lung disease in rheumatoid arthritis.
    Korean J Intern Med 2017 Mar 28. Epub 2017 Mar 28.
    Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
    Background/aims: To analyze clinical characteristics of interstitial lung disease (ILD) associated with rheumatoid arthritis (RA), especially in patients with poor prognosis.

    Methods: Seventy-seven RA patients with ILD and 231 age, sex, and disease duration-matched RA patients without ILD were enrolled in this retrospective study. Epidemiologic, clinical, and laboratory information were obtained through a medical chart review. Read More

    Carnosic acid (CA) attenuates collagen-induced arthritis in db/db mice via inflammation suppression by regulating ROS-dependent p38 pathway.
    Free Radic Biol Med 2017 Mar 23;108:418-432. Epub 2017 Mar 23.
    Department of Rheumatology and Immunology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, PR China. Electronic address:
    Rheumatoid arthritis (RA) is a multifactorial autoimmune disease, characterized by inflammation of synovial joints. Carnosic acid (CA) is a phenolic diterpene isolated from Rosmarinus officinailis, playing a central role in cytoprotective responses to oxidative stress and inflammation response. Our study aimed to investigate the effects of CA on RA progression in diabetic animals. Read More

    Role of enzymatic free radical scavengers in management of oxidative stress in autoimmune disorders.
    Int J Biol Macromol 2017 Mar 23;101:502-517. Epub 2017 Mar 23.
    University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chattissgarh, 492010, India. Electronic address:
    Autoimmune disorders are distinct with over production and accumulation of free radicals due to its undisclosed genesis. The cause of numerous disorders as cancer, arthritis, psoriasis, diabetes, alzheimer's, cardiovascular disease, Parkinson's, respiratory distress syndrome, colitis, crohn's, pulmonary fibrosis, obesity and ageing have been associated with immune dysfunction and oxidative stress. In an oxidative stress, reactive oxygen species generally provoke the series of oxidation at cellular level. Read More

    The latest treatment strategy for the rheumatoid hand deformity.
    J Orthop Sci 2017 Mar 22. Epub 2017 Mar 22.
    Department of Rheumatology, Niigata Rheumatic Center, Japan, 1-2-8 Honcho, Shibata City, Niigata 957-0054 Japan. Electronic address:
    With a remarkable improvement in the pharmacotherapy of rheumatoid arthritis (RA), severely handicapped patients are very rare to see. Healing, repair and drug-free, and toward radical cure are coming to be possible. In the clinical practice, more than 50% of the patients are in remission. Read More

    Thresholds for the 28-joint disease activity score (DAS28) using C-reactive protein are lower compared to DAS28 using erythrocyte sedimentation rate in early rheumatoid arthritis.
    Clin Exp Rheumatol 2017 Mar 23. Epub 2017 Mar 23.
    Sinai Health System, University of Toronto, Canada; and Hospital for Special Surgery, New York, USA.
    Objectives: The 28-Joint Disease Activity Score (DAS28) using C-reactive protein (CRP) and DAS28 using erythrocyte sedimentation rate (DAS28-ESR) may not be interchangeable. We sought to compare and estimate optimal thresholds for the DA28-CRP for use in early rheumatoid arthritis (ERA).

    Methods: Patients from the Canadian Early Arthritis Cohort with baseline and 12 months' data for both DAS28-ESR and DAS28-CRP were examined for correlations and differences between DAS28-CRP and DAS28-ESR across their range of values. Read More

    Anticollagen type II antibodies are associated with an acute onset rheumatoid arthritis phenotype and prognosticate lower degree of inflammation during 5 years follow-up.
    Ann Rheum Dis 2017 Mar 23. Epub 2017 Mar 23.
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala Sweden.
    Objective: Antifibrillar collagen type II (anti-CII) antibody-positive patients with rheumatoid arthritis (RA) have early but not late signs of increased inflammation and joint erosions. We wanted to replicate this in a large RA cohort, and to relate to human leukocyte antigen (HLA)-DRB1* alleles.

    Methods: Anti-CII and anti-cyclic citrullinated peptide (CCP)2 were measured at baseline in 773 patients with RA from the Swedish Epidemiological Investigation in Rheumatoid Arthritis (EIRA) study with clinical follow-up data from the Swedish Rheumatology Quality Register (SRQ) registry, and 1476 with HLA-DRB1* information. Read More

    Long-term safety and efficacy of biosimilar infliximab among patients with inflammatory arthritis switched from reference product.
    Open Access Rheumatol 2017 7;9:29-35. Epub 2017 Mar 7.
    Department of Rheumatology, Galway University Hospitals, Galway, Ireland.
    Purpose: To evaluate the efficacy and safety of the biosimilar infliximab in adult patients with inflammatory arthritis switched from reference product in our center.

    Patients And Methods: In April 2014, patients attending our rheumatology service for infliximab infusions were switched from reference product to the biosimilar infliximab following consent and hospital approval.

    Results: Around 34 patients with inflammatory arthritis were switched from reference product to biosimilar infliximab in 2014: 50% female, mean age 55 years (standard deviation=12. Read More

    Development of a Selective Inhibitor of Protein Arginine Deiminase 2.
    J Med Chem 2017 Apr 31;60(7):3198-3211. Epub 2017 Mar 31.
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School , 364 Plantation Street, Worcester, Massachusetts 01605, United States.
    Protein arginine deiminase 2 (PAD2) plays a key role in the onset and progression of multiple sclerosis, rheumatoid arthritis, and breast cancer. To date, no PAD2-selective inhibitor has been developed. Such a compound will be critical for elucidating the biological roles of this isozyme and may ultimately be useful for treating specific diseases in which PAD2 activity is dysregulated. Read More

    Improved disease activity with fosdagrocorat (PF-04171327), a partial agonist of the glucocorticoid receptor, in patients with rheumatoid arthritis: a Phase 2 randomized study.
    Int J Rheum Dis 2017 Mar 22. Epub 2017 Mar 22.
    Pfizer Inc, Groton, Connecticut, USA.
    Aim: To assess efficacy and safety of fosdagrocorat (PF-04171327), a potential dissociated agonist of the glucocorticoid receptor, in rheumatoid arthritis (RA) patients.

    Methods: This multicenter, double-blind, parallel-group, active- and placebo-controlled Phase 2 study (NCT00938587) randomized 86 patients (1 : 1 : 1 : 1) to receive fosdagrocorat 10 mg, fosdagrocorat 25 mg, prednisone 5 mg or placebo, all with stable background methotrexate therapy. The primary outcome was change from baseline in Disease Activity Score of 28 joints (DAS28-4[C-reactive protein (CRP)]) after 2 weeks of treatment. Read More

    Quercetin and Ascorbic Acid Suppress Fructose-Induced NLRP3 Inflammasome Activation by Blocking Intracellular Shuttling of TXNIP in Human Macrophage Cell Lines.
    Inflammation 2017 Mar 22. Epub 2017 Mar 22.
    Division of Rheumatology, Department of Internal Medicine, Catholic University of Daegu School of Medicine, 33, Duryugongwon-ro 17-gil, Nam-gu, Daegu, 42472, Republic of Korea.
    The aim of this study was to identify the role of thioredoxin-interacting protein (TXNIP) and its interaction with antioxidants in the activation of the fructose-induced NOD-like receptor protein 3 (NLRP3) inflammasome in human macrophages. The study was performed with U937 and THP-1 macrophage cell lines. Total reactive oxygen species (ROS) were measured by flow cytometry. Read More

    The potent inhibitory effect of β-D-mannuronic acid (M2000) as a novel NSAID with immunosuppressive property on anti-cyclic citrullinated peptide antibodies, rheumatoid factor and anti-dsDNA antibodies in patients with rheumatoid arthritis.
    Curr Drug Discov Technol 2017 Mar 21. Epub 2017 Mar 21.
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
    Objective: To investigate the inhibitory effect of β-D-mannuronic acid (M2000) on anti-cyclic citrullinated peptide antibodies (anti-CCP), rheumatoid factor (RF), anti-double strand DNA (anti-dsDNA) and acute phase reactants in rheumatoid arthritis (RA) patients.

    Methods: The study included 40 patients with RA who had an inadequate response to conventional therapy (identifier: IRCT2014011213739N2). The patients were permitted to continue the conventional therapy excluding NSAIDs. Read More

    Anti-inflammatory and Antioxidant Actions of Copaiba Oil Are Related to Liver Cell Modifications in Arthritic Rats.
    J Cell Biochem 2017 Mar 21. Epub 2017 Mar 21.
    Department of Biochemistry, State University of Maringa, PR, Brazil.
    The present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status and liver cell metabolism of rats with adjuvant-induced arthritis. The later is an experimental autoimmune pathology that shares many features with the human rheumatoid arthritis. Holtzman rats were distributed into the following groups: control (healthy) rats; control rats treated with copaiba oil at the doses of 0. Read More

    Anti-Toxoplasma antibodies in Egyptian rheumatoid arthritis patients.
    Rheumatol Int 2017 May 20;37(5):785-790. Epub 2017 Mar 20.
    Department of Clinical Pathology, Faculty of Medicine, Mansoura University, 2 El-Gomhouria Street, Mansoura, 35516, Egypt.
    Objective: To assess seroprevalence of anti-Toxoplasma gondii antibodies; both IgG and IgM in Egyptian rheumatoid arthritis (RA) patients versus a non-RA group and to compare anti-Toxoplasma antibodies seroprevalence among RA patients receiving traditional treatment and RA patients treated with biologic drug.

    Methods: 60 RA patients and 60 healthy controls were enrolled in the study. Patients were categorized into two groups: one group included 30 patients receiving disease modifying anti-rheumatic drugs (DMARDs), while the other group included 30 patients receiving biologic agent, infliximab, a TNF-α antagonist. Read More

    B cell epitope of human cytomegalovirus phosphoprotein 65 (HCMV pp65) induced anti-dsDNA antibody in BALB/c mice.
    Arthritis Res Ther 2017 Mar 21;19(1):65. Epub 2017 Mar 21.
    Department of Medicine, Division of Allergy, Immunology and Rheumatology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 5, Fu-Shin St. Kwei-Shan, Taoyuan, 33375, Taiwan, Republic of China.
    Background: HCMV phosphoprotein 65 (HCMVpp65) is a putative immunogen that acts as an accelerator, inducing autoantibody and exacerbating autoimmune response in susceptible animals. The immunity to pp65336-439 instigates autoimmunity, suggesting that pp65336-439 contains crucial B cell epitope(s) for the development of nephritis. This study narrowed down the target epitope to pp65422-439 for immunization of BALB/c mice and mapping of B cell epitope. Read More

    Risk factors for flare and treatment of disease flares during pregnancy in rheumatoid arthritis and axial spondyloarthritis patients.
    Arthritis Res Ther 2017 Mar 20;19(1):64. Epub 2017 Mar 20.
    Department of Rheumatology, Immunology and Allergology, University Hospital, University of Bern, Freiburgstrasse 8, 3010, Bern, Switzerland.
    Background: During pregnancy, patients with rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA) can experience active disease, which might be influenced by adjustment of treatment around conception. The aim of this study was to identify possible risk factors of disease flares during pregnancy and to evaluate the effect of treatment in pregnant patients experiencing a flare.

    Methods: Pregnant patients with RA and axSpA were prospectively followed before, during, and after pregnancy. Read More

    Inflammatory 'double hit' model of temporomandibular joint disorder with elevated CCL2, CXCL9, CXCL10, RANTES and behavioural hypersensitivity in TNFR1/R2-/- mice.
    Eur J Pain 2017 Mar 20. Epub 2017 Mar 20.
    Department of Physiology, College of Medicine, University of Kentucky, Lexington, USA.
    Background: Patients with temporomandibular joint disorders (TMD), reactive arthritis and rheumatoid arthritis often have combined etiology of hereditary and microenvironmental factors contributing to joint pain. Multiple clinical and animal studies indicate 'double-hit' inflammatory insults can cause chronic inflammation. The first inflammatory insult primes the immune system and subsequent insults elicit amplified responses. Read More

    Bone degeneration, Inflammation and Secondary complications of Arthritis: Potential Targets and their Natural inhibitors.
    Mini Rev Med Chem 2017 Mar 15. Epub 2017 Mar 15.
    Department of Studies in Biochemistry, University of Mysore, Mysore. India.
    Arthritis is marked with joint deterioration that affects articular cartilage and subchondral bone. Though cartilage degradation is a major damage during arthritis, the subsequent bone loss cannot be neglected. Progress in the arthritis research has identified clinical importance of bone erosion in destructive arthritis. Read More

    Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer.
    Cell Death Dis 2017 Mar 16;8(3):e2682. Epub 2017 Mar 16.
    Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
    Cystatin SN (CST1) is a specific inhibitor belonging to the cystatin superfamily that controls the proteolytic activities of cysteine proteases such as cathepsins. Our previous study showed that high CST1 expression enhances tumor metastasis and invasiveness in colorectal cancer. Recently, auranofin (AF), a gold(I)-containing thioredoxin reductase 1 (TrxR1) inhibitor, has been used clinically to treat rheumatoid arthritis. Read More

    Utility of Dose Frequency Adjustment in Tocilizumab Administration for Rheumatoid Arthritis.
    J Rheumatol 2017 Mar 15. Epub 2017 Mar 15.
    From the Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan. S. Saito, MD, Rheumatologist, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine; Y. Kaneko, MD, PhD, Rheumatologist, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine; K. Izumi, MD, PhD, Rheumatologist, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine; T. Takeuchi, MD, PhD, Rheumatologist, Professor, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine. Address correspondence to Dr. T. Takeuchi, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan. E-mail: Accepted for publication January 25, 2017.
    Objective: To assess the utility of dose frequency adjustment of tocilizumab (TCZ) in rheumatoid arthritis (RA).

    Methods: Patients who received TCZ at 3-week (n = 24) or 5-week (n = 61) interval were evaluated.

    Results: Disease Activity Score at 28 joints based on erythrocyte sedimentation rate in the 3-week group significantly improved after 3 administrations at 3-week intervals (from 4. Read More

    Charlson Comorbidity Index Is Related to Organ Damage in Systemic Lupus Erythematosus: Data from KORean lupus Network (KORNET) Registry.
    J Rheumatol 2017 Mar 15. Epub 2017 Mar 15.
    From the Division of Rheumatology, Department of Internal Medicine, Arthritis and Autoimmunity Research Center, Catholic University of Daegu School of Medicine, Daegu; Department of Rheumatology, Chonnam National University Medical School, Gwangju, Republic of Korea. Supported by the Research Program funded by the Korea Centers for Disease Control and Prevention (grant number 2014-E63002-00). S.K. Kim, MD, PhD, Division of Rheumatology, Department of Internal Medicine, Arthritis and Autoimmunity Research Center, Catholic University of Daegu School of Medicine; J.Y. Choe, MD, PhD, Division of Rheumatology, Department of Internal Medicine, Arthritis and Autoimmunity Research Center, Catholic University of Daegu School of Medicine; S.S. Lee, MD, PhD, Department of Rheumatology, Chonnam National University Medical School. Address correspondence to Dr. S.K. Kim, Division of Rheumatology, Department of Internal Medicine, Arthritis and Autoimmunity Research Center, Catholic University of Daegu School of Medicine, 33, Duryugongwon-ro 17-gil, Nam-gu, Daegu 705-718, Republic of Korea. E-mail: Accepted for publication January 12, 2017.
    Objective: The aim of this study was to identify whether comorbidity status is associated with organ damage in patients with systemic lupus erythematosus (SLE).

    Methods: A total of 502 patients with SLE enrolled in the KORean lupus Network were consecutively recruited. Data included demographics, age-adjusted Charlson Comorbidity Index (CCIa), disease activity indexes, the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI), the Medical Outcomes Study Short Form-36 health survey (SF-36) score, and the Beck Depression Inventory (BDI) score. Read More

    Anti-carbamylated protein antibodies in rheumatoid arthritis patients are reactive to specific epitopes of the human fibrinogen β-chain.
    Arthritis Rheumatol 2017 Mar 15. Epub 2017 Mar 15.
    Objective: Anti-carbamylated protein antibodies (ACarPA) are associated with rheumatoid arthritis (RA) risk and severity and are primarily directed against fibrinogen. The lack of understanding of ACarPA reactivity has limited analysis of their immunopathogenic associations in RA. To address this shortcoming, we mapped ACarPA epitope reactivity in RA patient sera. Read More

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