13,807 results match your criteria Reactive Arthritis


Associations between D3R expression in synovial mast cells and disease activity and oxidant status in patients with rheumatoid arthritis.

Clin Rheumatol 2018 Jun 22. Epub 2018 Jun 22.

Department of Laboratory, The Second Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, People's Republic of China.

Dopamine D3 receptor (D3R) on immune cells is involved in the pathogenesis of rheumatoid arthritis (RA). Mast cells (MCs) are currently identified as important effector cells in synovial inflammation of RA, but little is known about the role of D3R on synovial MCs in the pathogenesis of RA. Several inflammatory cells in the synovium induce reactive oxygen species (ROS) formation which are involved in the progression of RA. Read More

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June 2018
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Unique Variant of NOD2 Pediatric Granulomatous Arthritis With Severe 1,25-Dihydroxyvitamin D-Mediated Hypercalcemia and Generalized Osteosclerosis.

J Bone Miner Res 2018 Jun 22. Epub 2018 Jun 22.

Pediatrics / Hematology, CHOC Children's Hospital - UC Irvine; Orange, CA 92868, USA.

Pediatric granulomatous arthritis (PGA) refers to two formerly separate entities; autosomal dominant Blau syndrome (BS) and its sporadic phenocopy early-onset sarcoidosis (EOS). In 2001 BS and in 2005 EOS became explained by heterozygous mutations within the gene that encodes nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also called caspase recruitment domain-containing protein 15 (CARD15). NOD2 is a microbe sensor in leukocyte cytosol that activates and regulates inflammation. Read More

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Miltirone-induced apoptosis in cisplatin-resistant lung cancer cells through upregulation of p53 signaling pathways.

Authors:
Zhongcheng Zhu

Oncol Lett 2018 Jun 5;15(6):8841-8846. Epub 2018 Apr 5.

Department of Radiotherapy, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China.

The active ingredients of natural plants are important sources of antitumor agents. Miltirone is a major effective ingredient in traditional Chinese medicine and it is considered to have anti-infection and immunosuppressive activities. Clinically, it is often used for the treatment of arthritis and immune diseases. Read More

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Sialylated Autoantigen-Reactive IgG Antibodies Attenuate Disease Development in Autoimmune Mouse Models of Lupus Nephritis and Rheumatoid Arthritis.

Front Immunol 2018 6;9:1183. Epub 2018 Jun 6.

Laboratories of Immunology and Antibody Glycan Analysis, Institute for Nutrition Medicine, University of Lübeck and University Medical Center Schleswig-Holstein, Lübeck, Germany.

Pro- and anti-inflammatory effector functions of IgG antibodies (Abs) depend on their subclass and Fc glycosylation pattern. Accumulation of non-galactosylated (agalactosylated; G0) IgG Abs in the serum of rheumatoid arthritis and systemic lupus erythematosus (SLE) patients reflects severity of the diseases. In contrast, sialylated IgG Abs are responsible for anti-inflammatory effects of the intravenous immunoglobulin (pooled human serum IgG from healthy donors), administered in high doses (2 g/kg) to treat autoimmune patients. Read More

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Pathogenic citrulline-multispecific B cell receptor clades in rheumatoid arthritis.

Arthritis Rheumatol 2018 Jun 21. Epub 2018 Jun 21.

Division of Rheumatic and Autoimmune Diseases, Department of Medicine and Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.

Objective: Anti-citrullinated protein antibodies (ACPA) have proven highly useful as biomarkers in rheumatoid arthritis (RA). However, the composition and functionality of the associated autoreactive B cell repertoire have not been directly assessed. We aimed to selectively investigate citrullinated autoantigen-specific B cell receptors (BCRs) involved in RA and initiate studies on their pathogenicity. Read More

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Effect of tildrakizumab (MK-3222), a high affinity, selective anti-IL23p19 monoclonal antibody, on cytochrome P450 metabolism in subjects with moderate to severe psoriasis.

Br J Clin Pharmacol 2018 Jun 21. Epub 2018 Jun 21.

Merck & Co., Inc., Kenilworth, NJ, USA.

Aims: Tildrakizumab, an interleukin (IL)-23 inhibitor, is indicated for the treatment of moderate to severe chronic plaque psoriasis. Although tildrakizumab is not metabolized by, and does not alter, cytochrome P450 (CYP) expression in vitro, clinically-significant pharmacokinetic effects through changes in systemic inflammation, which alters CYP metabolism, have been well documented. At the time of study conduct, the effect of modulation of inflammation/cytokines, including IL-23 inhibition with tildrakizumab, on CYP metabolism, and therefore the potential for disease-drug interactions, in psoriasis patients was unknown. Read More

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June 2018
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Usefulness of tocilizumab for treating rheumatoid arthritis with myelodysplastic syndrome: A case report and literature review.

Medicine (Baltimore) 2018 Jun;97(25):e11179

Department of Rheumatology.

Rationale: Dysregulated immune function in rheumatoid arthritis (RA) might lead to the development of myelodysplastic syndrome (MDS). Serum interleukin-6 (IL-6) concentrations are increased in both RA and MDS patients.

Patient Concerns: A 58-year-old woman presented with severe RA. Read More

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Factors correlated with the improvement of endothelial dysfunction during Abatacept therapy in patients with rheumatoid arthritis.

J Inflamm Res 2018 7;11:247-252. Epub 2018 Jun 7.

Immunology and Allergology Laboratory Unit, Hospital S. Giovanni di Dio, Azienda USL-Toscana Centro, Florence, Italy.

Background: Rheumatoid arthritis patients are exposed to a high risk of cardiovascular morbidity and mortality even in the early phases of the disease.

Methods: We evaluated carotid common carotid intimal media thickness (ccIMT) intimal thickness and brachial flow-mediated dilation (FMD) of 45 rheumatoid arthritis patients without known cardiovascular risk factors or heart disease on a stable dose of 5.2±1. Read More

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June 2018
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Presence of hepatitis B virus in synovium and its clinical significance in rheumatoid arthritis.

Arthritis Res Ther 2018 Jun 19;20(1):130. Epub 2018 Jun 19.

Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.

Background: Previous studies have revealed that hepatitis B virus (HBV) infection may be related to rheumatoid arthritis (RA), but there are no studies on the presence of HBV antigens or nucleic acid in synovium from patients with RA with HBV infection. In the present study, we investigated the presence of HBV in the synovium and its clinical significance in RA.

Methods: Fifty-seven consecutive patients with active RA (Disease Activity Score 28-joint assessment based on C-reactive protein ≥ 2. Read More

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Safety and efficacy of upadacitinib in patients with active rheumatoid arthritis refractory to biologic disease-modifying anti-rheumatic drugs (SELECT-BEYOND): a double-blind, randomised controlled phase 3 trial.

Lancet 2018 Jun 12. Epub 2018 Jun 12.

AbbVie Inc, North Chicago, IL, USA.

Background: Phase 2 studies with upadacitinib, a selective Janus kinase 1 (JAK1) inhibitor, have shown safety and efficacy in the treatment of patients with active rheumatoid arthritis. We did this study to further assess the safety and efficacy of upadacitinib in patients with an inadequate response to biologic disease-modifying anti-rheumatic drugs (bDMARDs).

Methods: We did this double-blind, randomised controlled phase 3 trial at 153 sites in 26 countries. Read More

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Safety and efficacy of upadacitinib in patients with rheumatoid arthritis and inadequate response to conventional synthetic disease-modifying anti-rheumatic drugs (SELECT-NEXT): a randomised, double-blind, placebo-controlled phase 3 trial.

Lancet 2018 Jun 12. Epub 2018 Jun 12.

AbbVie Inc, North Chicago, IL, USA.

Background: Upadacitinib is a selective inhibitor of Janus kinase 1 and was efficacious in phase 2 studies in patients with moderate-to-severe rheumatoid arthritis. We aimed to assess the efficacy of upadacitinib in patients with inadequate response to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs).

Methods: This study is a double-blind, placebo-controlled trial at 150 sites in 35 countries. Read More

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Metabolite assignment of Ultra-Filtered Synovial Fluid extracted from knee joints of Reactive Arthritis patients using High Resolution NMR spectroscopy.

Magn Reson Chem 2018 Jun 15. Epub 2018 Jun 15.

Department of Clinical Immunology, SGPGIMS, Raibareli Road, Lucknow, -226014, India.

Currently, there are no reliable clinical biomarkers available that can aid early differential diagnosis of reactive arthritis (ReA) from other inflammatory joint diseases. Metabolic profiling of synovial fluid (SF) -obtained from joints affected in ReA- holds great promise in this regard and will further aid monitoring treatment and improving our understanding about disease mechanism. As a first step in this direction, we report here the metabolite specific assignment of H and C resonances detected in the NMR spectra of SF samples extracted from human patients with established ReA. Read More

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Systematic review and meta-analysis of the efficacy and safety of Biqi capsule in rheumatoid arthritis patients.

Exp Ther Med 2018 Jun 2;15(6):5221-5230. Epub 2018 May 2.

Department of Rheumatology, The Second Affiliated Hospital, (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China.

Biqi capsule is a Traditional Chinese Medicine preparation for treating rheumatoid arthritis (RA), and clinical studies have indicatedthat its effect may be more beneficial than that of Western medicine. The present study aimed to estimate the efficacy and safety of Biqi capsule alone or combined with methotrexate (MTX) compared with MTX alone for treating RA by performing a meta-analysis of randomized controlled trials and controlled clinical trials. A systematic literature search of studies published until March 2017 was performed. Read More

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June 2018
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Exposure-Response Modeling Analyses for Sirukumab, a Human Monoclonal Antibody Targeting Interleukin 6, in Patients With Moderately to Severely Active Rheumatoid Arthritis.

J Clin Pharmacol 2018 Jun 14. Epub 2018 Jun 14.

Global Clinical Pharmacology, Janssen Research & Development, LLC., Spring House, PA, USA.

To characterize the dose-exposure-response relationship of sirukumab, an anti-interleukin 6 human monoclonal antibody, in the treatment of moderately to severely active rheumatoid arthritis (RA), we conducted exposure-response (E-R) modeling analyses based on data from two pivotal phase 3 placebo-controlled trials of sirukumab in patients with RA who were inadequate responders to nonbiologic disease-modifying antirheumatic drugs or anti-tumor necrosis factor α agents. A total of 2176 patients were included for the analyses and received subcutaneous administration of either placebo or sirukumab 50 mg every 4 weeks or 100 mg every 2 weeks. The clinical endpoints were 20%, 50%, and 70% improvement in the American College of Rheumatology response criteria (ie, ACR20, ACR50, and ACR70), and 28-joint Disease Activity Index Score (DAS28) using C-reactive protein. Read More

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The Relationship Between Serum Pentraxine 3 Levels and Hematological Markers in Patients With Rheumatoid Arthritis.

Arch Rheumatol 2018 Mar 13;33(1):39-44. Epub 2017 Sep 13.

Divison of Rheumatology, Department of Pysical Medicine and Rehabilitation, Abant İzzet Baysal University Faculty of Medicine, Bolu, Turkey.

Objectives: This study aims to investigate the association of pentraxin 3 (PTX3) with neutrophil/lymphocyte ratio (NLR) rather than the disease activity score 28 using C-reactive protein in rheumatoid arthritis (RA).

Patients And Methods: The study included 59 RA patients (11 males, 48 females; mean age 53.79±13. Read More

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Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study.

Arthritis Res Ther 2018 Jun 14;20(1):127. Epub 2018 Jun 14.

Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease in which adults have significant joint issues leading to poor health. Poor health is compounded by many factors, including exercise avoidance and increased risk of opportunistic infection. Exercise training can improve the health of patients with RA and potentially improve immune function; however, information on the effects of high-intensity interval training (HIIT) in RA is limited. Read More

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June 2018
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Oxidative damage markers and inflammatory cytokines are altered in patients suffering with post Chikungunya persisting polyarthralgia.

Free Radic Res 2018 Jun 14:1-161. Epub 2018 Jun 14.

a Department of Laboratory Medicine , School of Tropical Medicine , Kolkata , India.

Redox homeostasis is necessary for maintenance of living systems. Chikungunya viral infection manifests into joint inflammation and debilitating polyarthralgia affecting the life style of the patient badly. The disease pathophysiology is poorly understood and there is a lack of targeted therapeutics. Read More

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Poncet's disease in an adolescent with abdominal tuberculosis.

Paediatr Int Child Health 2018 Jun 13:1-2. Epub 2018 Jun 13.

a Department of Paediatrics, Paediatric TB Clinic , B. J. Wadia Hospital for Children , Mumbai , India.

Poncet disease is a rare, acute-onset polyarthritis associated with active extra-articular tuberculosis (TB) without evidence of active infection in the affected joint and resolves without residual joint damage or long-term complications. Most cases are reported at the commencement of anti-tuberculous therapy (ATT). A 13-year-old girl with Poncet disease is reported which, despite almost 6 months of treatment for abdominal TB, manifested with bilateral knee joint involvement which resolved only with continuation of ATT. Read More

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Therapeutic potentials of superoxide dismutase.

Authors:
H Younus

Int J Health Sci (Qassim) 2018 May-Jun;12(3):88-93

Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

Superoxide dismutases (SODs) constitute a very important antioxidant defense against oxidative stress in the body. The enzyme acts as a good therapeutic agent against reactive oxygen species-mediated diseases. The present review describes the therapeutic effects of SOD in various physiological and pathological conditions such as cancer, inflammatory diseases, cystic fibrosis, ischemia, aging, rheumatoid arthritis, neurodegenerative diseases, and diabetes. Read More

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June 2018
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Effect of anti-rheumatic treatment on selenium levels in inflammatory arthritis.

J Trace Elem Med Biol 2018 Sep 3;49:91-97. Epub 2018 May 3.

Lillehammer Hospital for Rheumatic Diseases, Norway; Department of Research, Innlandet Hospital Trust, Brumunddal, Norway; Harvard Medical School, Boston, USA; Brigham and Women's Hospital, Boston, USA.

Objectives: The reason for increased cardiovascular risk in inflammatory arthritis (IA) is unclear. Interestingly, selenium-deficiency is suspected to contribute to the development of cardiovascular disease (CVD) in the general population. Although the reference range of serum selenium (s-selenium) is 50-120 μg/L, there are indications that levels up to 85 μg/L might not be sufficient for optimal cardioprotection. Read More

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September 2018

[Treatment of Rheumatoid Arthritis by Bee-venom Acupuncture].

Zhen Ci Yan Jiu 2018 Apr;43(4):251-4

Department of Acupuncture and Moxibustion, Bao'an Hospital of Traditional Chinese Medicine, Shenzhen 518133, Guangdong Province, China.

Objective: To study the clinical efficacy and safety of bee-venom acupuncture therapy for rheumatoid arthritis (RA).

Methods: A total of 120 cases of RA patients were randomized into bee-sting acupuncture group (treatment) and western medicine group (control) in accordance with the random number table. The patients of the control group were treated by oral administration of Methotrexate (10 mg, once a week) and Celecoxlb (0. Read More

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Prealbumin, platelet factor 4 and S100A12 combination at baseline predicts good response to TNF alpha inhibitors in Rheumatoid Arthritis.

Joint Bone Spine 2018 Jun 6. Epub 2018 Jun 6.

University Grenoble Alpes, GREPI, EA 7408, 38400, Saint-Martin-d'Hères, France; Rheumatology Department, Centre Hospitalier Universitaire Grenoble Alpes, Hôpital Sud Echirolles, 38130 Echirolles, France.

Objectives: Tumour necrosis factor-alpha inhibitors (TNFi) are effective treatments for Rheumatoid Arthritis (RA). Responses to treatment are barely predictable. As these treatments are costly and may induce a number of side effects, we aimed at identifying a panel of protein biomarkers that could be used to predict clinical response to TNFi for RA patients. Read More

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Patient reported outcomes more important than objective inflammatory markers for sick leave in biologics-treated rheumatoid arthritis patients.

Arthritis Care Res (Hoboken) 2018 Jun 8. Epub 2018 Jun 8.

Department of Clinical Sciences Lund, Rheumatology, Lund University, Lund, Sweden.

Objective: To study the impact of common, non-composite disease activity measures on sick leave in biologics-treated RA-patients.

Methods: Study visits of biologics-treated RA-patients of working-age (<65y), in the observational South Swedish Arthritis Treatment Group register 2005-2011, were included (5118 visits; 941 patients). We performed association analyses between various non-composite disease activity measures at each visit and number of sick leave days during the month thereafter, retrieved from the Social Insurance Agency. Read More

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Cerebral amyloid angiopathy-related inflammation with epilepsy mimicking a presentation of brain tumor: A case report and review of the literature.

Int J Surg Case Rep 2018 May 29;48:95-100. Epub 2018 May 29.

Department of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime 791-0295, Japan.

Introduction: Cerebral amyloid angiopathy-related inflammation (CAA-ri), a rare and treatable variant of cerebral amyloid angiopathy, lacks specific imaging and clinical features, and requires invasive brain biopsy to confirm the diagnosis. We report the case of a patient with nonconvulsive status epilepticus (NCSE) caused by CAA-ri in the right occipital lobe.

Presentation Of Case: A 78-year-old man with a history of hypertension and rheumatoid arthritis was admitted to our hospital following an episode of seizures. Read More

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May 2018
2 Reads

Luteolin attenuates neutrophilic oxidative stress and inflammatory arthritis by inhibiting Raf1 activity.

Biochem Pharmacol 2018 Jun 6;154:384-396. Epub 2018 Jun 6.

Graduate Institute of Natural Products and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan; Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan; Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan; Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City 243, Taiwan. Electronic address:

Neutrophils play a significant role in inflammatory tissue injury. Activated neutrophils produce reactive oxygen species (ROS), release proteases, and form neutrophil extracellular traps (NETs), significantly affecting the pathogenesis of inflammatory arthritis. We examined the therapeutic effects of luteolin, a flavone found in many plants, in neutrophilic inflammation and on acute inflammatory arthritis. Read More

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June 2018
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The add-on effectiveness and safety of iguratimod in patients with rheumatoid arthritis who showed an inadequate response to tocilizumab.

Mod Rheumatol 2018 Jun 8:1-19. Epub 2018 Jun 8.

a Department of Orthopaedic Surgery , Osaka University Graduate School of Medicine , Osaka , Japan.

Objectives: To evaluate the effectiveness of add-on iguratimod (IGU) in patients with rheumatoid arthritis (RA) who showed an inadequate response to tocilizumab (TCZ), especially patients who were intolerant of an effective dose of methotrexate (MTX).

Methods: Thirty-one patients with RA (22 women, age 62.4 years, disease duration 13. Read More

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June 2018
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Niclosamide as an adjuvant to etanercept in treatment patients with active rheumatoid arthritis: an 8-week randomized controlled pilot study.

Clin Rheumatol 2018 Jun 7. Epub 2018 Jun 7.

Department of Pharmacy, Al-Isra'a University, Baghdad, Iraq.

This study designed to identify the therapeutic efficacy of niclosamide (NCL) in Iraqi patients suffering from active rheumatoid arthritis (RA) who were using etanercept (ETN) for more than 3 months and still had high or moderate active RA. One hundred ten patients suffering from active rheumatoid arthritis (RA) who were using etanercept (ETN) for more than 3 months and still had high or moderate active RA were allocated randomly into two equal groups: one of them treated with 1000 mg/day NCL and the other treated with 1000 mg/day lactose in capsule dosage form. The study duration was 8 weeks. Read More

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June 2018
3 Reads

Evaluation of the Efficacy of Combined Therapy of Methotrexate and Etanercept versus Methotrexate as a Mono-Therapy.

Open Access Maced J Med Sci 2018 May 24;6(5):786-789. Epub 2018 Apr 24.

Clinic for Cardiology, University of Clinical Centre of Kosovo, Prishtina, Kosovo.

Aim: This study aims to evaluate the efficacy of Methotrexate (MTX) alone and combined therapy with Etanercept (ETN) and Methotrexate in patients with active rheumatoid arthritis (RA).

Methods: In the randomised control study, conducted in the period from March 2014 until March 2016, we evaluated the efficacy of the treatment of patients with RA with MTX as monotherapy and combination treatment with MTX and ETN. In the Clinic of Rheumatology in Prishtina, 90 adult patients with RA were treated in combination with ETN (doses of 50 mg subcutaneously/weekly), with oral MTX (doses up to 20 mg weekly), and MTX alone (doses up to 20 mg weekly) during this period of two years. Read More

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May 2018
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Protection Against Arthritis by the Parasitic Worm Product ES-62, and Its Drug-Like Small Molecule Analogues, Is Associated With Inhibition of Osteoclastogenesis.

Front Immunol 2018 14;9:1016. Epub 2018 May 14.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.

The immunomodulatory actions of parasitic helminth excretory-secretory (ES) products that serendipitously protect against development of chronic inflammatory disorders are well established: however, knowledge of the interaction between ES products and the host musculoskeletal system in such diseases is limited. In this study, we have focused on ES-62, a glycoprotein secreted by the rodent filarial nematode that is immunomodulatory by virtue of covalently attached phosphorylcholine (PC) moieties, and also two synthetic drug-like PC-based small molecule analogues (SMAs) that mimic ES-62's immunomodulatory activity. We have previously shown that each of these molecules prevents development of pathology in collagen-induced arthritis (CIA), a model of the musculoskeletal disease rheumatoid arthritis (RA) and reflecting this, we now report that ES-62 and its SMAs, modify bone remodeling by altering bone marrow progenitors and thus impacting on osteoclastogenesis. Read More

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May 2018
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Gemcabene, a First-in-Class Hypolipidemic Small Molecule in Clinical Development, Attenuates Osteoarthritis and Pain in Animal Models of Arthritis and Pain.

Front Pharmacol 2018 11;9:471. Epub 2018 May 11.

Gemphire Therapeutics Inc., Livonia, MI, United States.

Our clinical studies have demonstrated that gemcabene, a small molecule in late-stage clinical development, lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP). This observation was further confirmed in a cell-based study showing inhibition of cytokine-induced CRP production. Based on these observations, in the present study, we tested the hypothesis that gemcabene may possess anti-inflammatory activities in animal models of inflammatory disease. Read More

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May 2018
1 Read

Biocompatible Gold Nanoparticles Ameliorate Retinoic Acid-Induced Cell Death and Induce Differentiation in F9 Teratocarcinoma Stem Cells.

Nanomaterials (Basel) 2018 Jun 1;8(6). Epub 2018 Jun 1.

Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea.

The unique properties of gold nanoparticles (AuNPs) have attracted much interest for a range of applications, including biomedical applications in the cosmetic industry. The current study assessed the anti-oxidative effect of AuNPs against retinoic acid (RA)-induced loss of cell viability; cell proliferation; expression of oxidative and anti-oxidative stress markers, pro- and anti-apoptotic genes, and differentiation markers; and mitochondrial dysfunction in F9 teratocarcinoma stem cells. AuNPs were prepared by reduction of gold salts using luteolin as a reducing and stabilizing agent. Read More

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June 2018
4 Reads

Oxidative stress in autoimmune rheumatic diseases.

Free Radic Biol Med 2018 May 30. Epub 2018 May 30.

University of Exeter Medical School, St Luke's Campus, Exeter, Devon EX1 2LU, UK.

The management of patients with autoimmune rheumatic diseases such as rheumatoid arthritis (RA) remains a significant challenge. Often the rheumatologist is restricted to treating and relieving the symptoms and consequences and not the underlying cause of the disease. Oxidative stress occurs in many autoimmune diseases, with the excess production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Read More

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May 2018
3 Reads

Hypertension: Focus on autoimmunity and oxidative stress.

Free Radic Biol Med 2018 May 30. Epub 2018 May 30.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK; Department of Internal and Agricultural Medicine, Jagiellonian University Collegium Medicum, Krakow, Poland. Electronic address:

Understanding the causal role of the immune and inflammatory responses in hypertension has led to questions regarding the links between hypertension and autoimmunity. Immune pathology in primary hypertension mimics several autoimmune mechanisms observed in the pathogenesis of systemic lupus erythematosus, psoriasis, systemic sclerosis, rheumatoid arthritis and periodontitis. More importantly, the prevalence of hypertension in patients with these autoimmune diseases is significantly increased, when compared to control populations. Read More

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May 2018
5 Reads

Association between inflammation and systolic blood pressure in RA compared to patients without RA.

Arthritis Res Ther 2018 Jun 1;20(1):107. Epub 2018 Jun 1.

Division of Rheumatology, Allergy and Immunology, Brigham and Women's Hospital, Boston, MA, 02115, USA.

Background: The relationship between inflammation and blood pressure (BP) has been studied mainly in the general population. In this study, we examined the association between inflammation and BP across a broader range of inflammation observed in rheumatoid arthritis (RA) and non-RA outpatients.

Methods: We studied subjects from a tertiary care outpatient population with C-reactive protein (CRP) and BP measured on the same date in 2009-2010; RA outpatients were identified using a validated algorithm. Read More

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June 2018
1 Read

Disease Characteristics and Change in Arthritis Activity according to Treatment in Hepatitis B Surface Antigen-positive Rheumatoid Arthritis Patients: a Retrospective Chart Review Study.

J Korean Med Sci 2018 Jun 10;33(23):e168. Epub 2018 May 10.

Deparment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Rheumatoid arthritis (RA) treatment may differ according to hepatitis B state and consequently may bring about different arthritis outcomes. However, whether hepatitis B affects treatment outcome remains unclear. We investigated differences in change in arthritis activity between RA patients according to concomitant hepatitis B virus infection. Read More

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June 2018
2 Reads

Analysis of Helios gene expression and Foxp3 TSDR methylation in the newly diagnosed Rheumatoid Arthritis patients.

Immunol Invest 2018 May 31:1-11. Epub 2018 May 31.

g Department of Immunology , Kermanshah University of Medical Sciences , Kermanshah , Iran.

Background: The control of auto-reactive cells is defective in rheumatoid arthritis (RA). Regulatory T (Treg) cells which play a key role in the modulation of immune responses have an impaired function in RA. Foxp3 is a master regulator of Treg cells which its expression is under the tight control of epigenetic mechanisms. Read More

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May 2018
4 Reads
1.90 Impact Factor

Diet Quality and Its Relationship with Antioxidant Status in Patients with Rheumatoid Arthritis.

Oxid Med Cell Longev 2018 5;2018:8506343. Epub 2018 Apr 5.

Department of Food Science and Dietetics, Wrocław Medical University, Borowska 211, 50-556 Wrocław, Poland.

A direct contribution towards destructive, proliferative synovitis in rheumatoid arthritis (RA) has been attributed to reactive oxygen species action. Some nutrients are considered to be capable of improving the oxidant/antioxidant status in RA; however the impact of diet composition on the antioxidant capacity of serum has not yet been studied in this disease. The aim of the study was to assess the relationship between diet quality and antioxidant status in patients with RA and healthy controls. Read More

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April 2018
2 Reads

Disease-association of different killer cell immunoglobulin-like receptors (KIR) and HLA-C gene combinations in reactive arthritis.

Mod Rheumatol 2018 May 31:1-20. Epub 2018 May 31.

a Department of Rheumatology and Immunology , Shandong Provincial Hospital Affiliated to Shandong University , Jinan , China.

Background: Reactive arthritis (ReA) is sterile arthritis triggered by bacterial gastrointenstinal or urogenital infections. Although the pathogenesis of ReA remains unclear, genetic factors seem to play an important role. Different killer cell immunoglobulin-like receptors (KIRs) and their corresponding specific histocompatibility leukocyte antigen-C (HLA-C) ligand genotypes have been implicated in susceptibility and resistance to infections and autoimmune diseases but have, thus far, not been investigated in ReA. Read More

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May 2018
1 Read

Exercise is Associated With Increased Small HDL Particle Concentration and Decreased Vascular Stiffness in Rheumatoid Arthritis.

J Clin Rheumatol 2018 May 25. Epub 2018 May 25.

Objective: Patients with rheumatoid arthritis (RA) have increased cardiovascular (CV) risk. In the general population, exercise improves several CV risk factors. In a cross-sectional study, we examined the hypothesis that more exercise is associated with protective traditional and non-traditional CV risk factor profile in patients with RA. Read More

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May 2018
1 Read

Oxidative stress impairs energy metabolism in primary cells and synovial tissue of patients with rheumatoid arthritis.

Arthritis Res Ther 2018 May 29;20(1):95. Epub 2018 May 29.

Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland.

Background: In this study, we examined the effect of oxidative stress on cellular energy metabolism and pro-angiogenic/pro-inflammatory mechanisms of primary rheumatoid arthritis synovial fibroblast cells (RASFC) and human umbilical vein endothelial cells (HUVEC).

Methods: Primary RASFC and HUVEC were cultured with the oxidative stress inducer 4-hydroxy-2-nonenal (4-HNE), and extracellular acidification rate, oxygen consumption rate, mitochondrial function and pro-angiogenic/pro-inflammatory mechanisms were assessed using the Seahorse analyser, complex I-V activity assays, random mutation mitochondrial capture assays, enzyme-linked immunosorbent assays and functional assays, including angiogenic tube formation, migration and invasion. Expression of angiogenic growth factors in synovial tissue (ST) was assessed by IHC in patients with rheumatoid arthritis (RA) undergoing arthroscopy before and after administration of tumour necrosis factor inhibitors (TNFi). Read More

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May 2018
4 Reads

[Acupuncture combined with western medicine on rheumatoid arthritis and effects on blood stasis].

Zhongguo Zhen Jiu 2018 May;38(5):4793-82

The Geriatrics, the Second Hospital Affiliated of Anhui University of CM, Hefei 230061, China.

Objective: To observe the clinical efficacy of acupuncture combined with western medicine in the treatment of rheumatoid arthritis (RA) and its effect on blood stasis, and to explore ways to improve the clinical curative effect.

Methods: A total of 56 patients of RA were randomly divided into an observation group and a control group, 28 cases in each one. ① ibuprofen sustained-release tablets, 2 times a day, each time 0. Read More

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May 2018
1 Read

Anti-cytokine therapy and plasma DNA in patients with rheumatoid arthritis.

Rheumatol Int 2018 May 23. Epub 2018 May 23.

1st Department of Internal Medicine, Faculty of Medicine, University Hospital, Comenius University, Mickiewiczova 13, Bratislava, Slovakia.

Background: Extracellular DNA (ecDNA) is increased in inflammation and it also induces inflammation. In patients with rheumatoid arthritis (RA), plasma ecDNA is higher than in healthy controls. Due to low specificity, it cannot be used for screening, but it might be useful for monitoring and prognosis of therapy success. Read More

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May 2018
1 Read

Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients.

Pharmacogenomics J 2018 May 25. Epub 2018 May 25.

Leeds Institute of Cancer and Pathology, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

Methotrexate (MTX) monotherapy is a common first treatment for rheumatoid arthritis (RA), but many patients do not respond adequately. In order to identify genetic predictors of response, we have combined data from two consortia to carry out a genome-wide study of response to MTX in 1424 early RA patients of European ancestry. Clinical endpoints were change from baseline to 6 months after starting treatment in swollen 28-joint count, tender 28-joint count, C-reactive protein and the overall 3-component disease activity score (DAS28). Read More

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May 2018
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The influence of thyroid diseases, diabetes mellitus, primary hyperparathyroidism, vitamin B12 deficiency and other comorbid autoimmune diseases on treatment outcome in patients with rheumatoid arthritis: An exploratory cohort study.

Medicine (Baltimore) 2018 May;97(21):e10865

Faculty of Health Sciences, University of Southern Denmark, Odense.

To investigate the impact of comorbid diseases on rheumatoid arthritis (RA) outcome.All patients diagnosed with RA since 2006, who were registered in our local Danbio registry, were included in this cohort study. Patients' demographics, serology results, and Disease Activity Score in 28 joints-C-reactive protein (DAS28-CRP) at the time of diagnosis and after 4 months of treatment initiation were collected. Read More

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May 2018
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Inhibition of Endothelial Progenitor Cells May Explain the High Cardiovascular Event Rate in Patients with Rheumatoid Arthritis.

QJM 2018 May 16. Epub 2018 May 16.

Department of Medicine and the Rheumatology Unit.

Background: Rheumatoid arthritis (RA) patients may suffer cardiovascular (CV) events much more than the general population, and CV disease is the leading cause of death in patients with RA. Our hypothesis was that impaired function of endothelial progenitor cells may contribute to endothelial dysfunction and the clinical CV events of patients with RA.

Methods: 27 RA patients (9 males and 18 females) with an active disease and 13 healthy subjects who served as the control group (9 males and 4 females) were enrolled to this prospective study. Read More

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May 2018
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The Association of Disease Activity, Pro-Inflammatory Cytokines, and Neurotrophic Factors with Depression in Patients with Rheumatoid Arthritis.

Brain Behav Immun 2018 May 19. Epub 2018 May 19.

Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University Hostpital, Jinju, Republic of Korea; Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Republic of Korea. Electronic address:

Inflammation and trophic factors (brain-derived neurotrophic factor [BDNF], vascular endothelial growth factor, glial cell line-derived neurotrophic factor, and insulin-like growth factor-1) are associated with depression in the general population. Rheumatoid arthritis (RA) is a chronic representative inflammatory autoimmune disease; however, the association of disease activity, pro-inflammatory cytokines, and neurotrophic factors with depression has not been sufficiently investigated. Therefore, we determined the prevalence of depression and risk factors for depression and deterioration of depressive symptoms in RA patients. Read More

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May 2018
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Association between IL-6 production in synovial explants from rheumatoid arthritis patients and clinical and imaging response to biologic treatment: A pilot study.

PLoS One 2018 22;13(5):e0197001. Epub 2018 May 22.

The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark.

Introduction: The need for biomarkers which can predict disease course and treatment response in rheumatoid arthritis (RA) is evident. We explored whether clinical and imaging responses to biologic disease modifying anti-rheumatic drug treatment (bDMARD) were associated with the individual's mediator production in explants obtained at baseline.

Methods: RA Patients were evaluated by disease activity score 28 joint C-reactive protein (DAS 28-)), colour Doppler ultrasound (CDUS) and 3 Tesla RA magnetic resonance imaging scores (RAMRIS). Read More

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May 2018
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Adding colchicine to immunosuppressive treatments; a potential option for biologics-refractory adult-onset Still's disease.

BMC Res Notes 2018 May 21;11(1):320. Epub 2018 May 21.

Department of Rheumatology, Fukushima Medical University School of Medicine, 1 Hikarigaoka Fukushima, Fukushima, 960-1295, Japan.

Background: Adult-onset Still's disease (AOSD) is a rare inflammatory disorder characterized by the classical triad of daily spiking fever, arthritis, and typical salmon-colored rash. Resistance to first-line corticosteroids and second-line disease modified anti-rheumatic-drugs defines refractory AOSD, which mostly includes the polycyclic or chronic courses of the disease. Anti-cytokine therapies are recommended in AOSD patients who are refractory to traditional treatments. Read More

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May 2018
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Vitamin D is not useful as a biomarker for disease activity in rheumatoid arthritis.

Reumatol Clin 2018 May 17. Epub 2018 May 17.

Centro de Reumatología y Rehabilitación, Guayaquil, Ecuador.

Objective: To determine whether there is an association between serum vitamin D levels and the Disease Activity Index in patients with rheumatoid arthritis (RA).

Methodology: An analytical, retrospective, cross-sectional study was performed at the Hospital Luis Vernaza and Center for Rheumatology and Rehabilitation. We included 18 to 75-year-old patients with a diagnosis of RA according to the 2010 classification criteria, and with a 25-hydroxyvitamin D (25 [OH] D) test within the last 3 months. Read More

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May 2018
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Pharmacokinetics and C-Reactive Protein Modelling of Anti-IL-6 Antibody (PF-04236921) in Healthy Volunteers and Patients with Autoimmune Disease.

Br J Clin Pharmacol 2018 May 18. Epub 2018 May 18.

Clinical Research, Pfizer Inc., 610 Main Street, Cambridge, MA, USA, 02140.

Aims: The purpose of this study was to characterize pharmacokinetics (PK) of PF-04236921, a novel anti-IL-6 monoclonal antibody, and its pharmacokinetics/pharmacodynamics (PK/PD) relationship on serum C-Reactive Protein (CRP) in healthy volunteers and patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Crohn's disease (CD) METHODS: Population modelling analyses were conducted using nonlinear mixed effects modelling. Data from 2 phase 1 healthy volunteer studies, a phase 1 RA study, a Phase 2 CD study, and a Phase 2 SLE study were included.

Results: A 2-compartment model with first order absorption and linear elimination and a mechanism-based indirect response model adequately described the PK and PK/PD relationships, respectively. Read More

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May 2018
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