7,560 results match your criteria Raynaud Phenomenon


Trajectories of glomerular filtration rate and progression to end stage kidney disease after kidney transplantation.

Kidney Int 2020 Aug 8. Epub 2020 Aug 8.

Université de Paris, INSERM, PARCC, Paris Translational Research Centre for Organ Transplantation, Paris, France; Kidney Transplant Department, Saint-Louis Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France. Electronic address:

Although the gold standard of monitoring kidney transplant function relies on glomerular filtration rate (GFR), little is known about GFR trajectories after transplantation, their determinants, and their association with outcomes. To evaluate these parameters we examined kidney transplant recipients receiving care at 15 academic centers. Patients underwent prospective monitoring of estimated GFR (eGFR) measurements, with assessment of clinical, functional, histological and immunological parameters. Read More

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http://dx.doi.org/10.1016/j.kint.2020.07.025DOI Listing

Current and Future MR Contrast Agents: Seeking a Better Chemical Stability and Relaxivity for Optimal Safety and Efficacy.

Invest Radiol 2020 Sep;55(9):578-588

From Guerbet, Roissy CDG Cedex, France.

This review summarizes 30 years of experience in the development and clinical use of magnetic resonance (MR) contrast agents. Despite their undisputable usefulness for disease diagnosis, gadolinium (Gd)-based contrast agents (GBCAs) have gone through 2 major safety crises. Approximately 10 years ago, the regulatory agencies decided to restrict the use of GBCAs to minimize the risk of nephrogenic systemic fibrosis in patients with severe renal insufficiency. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000684DOI Listing
September 2020

Type B insulin resistance syndrome associated with connective tissue disease and psoriasis.

Endocrinol Diabetes Metab Case Rep 2020 Aug 4;2020. Epub 2020 Aug 4.

Department of Internal Medicine and Metabolic Diseases, Diabetology and Internal Medicine.

Summary: Type B insulin resistance syndrome (TBIR) is characterised by the rapid onset of severe insulin resistance due to circulating anti-insulin receptor antibodies (AIRAs). Widespread acanthosis nigricans is normally seen, and co-occurrence with other autoimmune diseases is common. We report a 27-year-old Caucasian man with psoriasis and connective tissue disease who presented with unexplained rapid weight loss, severe acanthosis nigricans, and hyperglycaemia punctuated by fasting hypoglycaemia. Read More

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http://dx.doi.org/10.1530/EDM-20-0027DOI Listing

Nipple pain: Raynaud's beyond fingers and toes.

Breast J 2020 Aug 4. Epub 2020 Aug 4.

Breast Health Center, Women and Infants Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

Raynaud's phenomenon of the nipple (RPN) is a cause of nipple pain scarcely reported in the literature and frequently missed by physicians. We present a case of RPN in a pregnant mother who sought breast surgical consultation for episodic nipple pain. Review of the literature reveals RPN is predominant in lactating and pregnant patients and missed diagnosis can cause cessation of breastfeeding or mistreatment with antifungals. Read More

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http://dx.doi.org/10.1111/tbj.13991DOI Listing

Effectiveness and safety of Suxiao Jiuxin pill in treating acute coronary syndrome: a systematic review and Meta-analysis.

J Tradit Chin Med 2020 Aug;40(4):518-529

Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.

Objective: To evaluate the effectiveness and safety of Suxiao Jiuxin pill (SX) in acute coronary syndrome (ACS) treatment.

Methods: An extensive search of four English databases (Medline/PubMed, Cochrane Library, Embase, and World Health Organization International Clinical Trials Registration Platform) and four Chinese databases (Chinese National Knowledge Infrastructure, Wanfang, China Science and Technology Journal, and Chinese Biomedical Literature Service System) was performed. Randomized, controlled trials (RCTs) involving SX combined with conventional therapy versus conventional therapy were included. Read More

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http://dx.doi.org/10.19852/j.cnki.jtcm.2020.04.002DOI Listing
August 2020
0.667 Impact Factor

Effectiveness of Chinese herbal medicine for primary Raynaud's phenomenon: a systematic review and Meta-analysis of randomized controlled trials.

J Tradit Chin Med 2020 Aug;40(4):509-517

Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital University of Medicine Sciences, Beijing 100010, China.

Objective: To evaluate the effectiveness of Chinese herbal medicine for primary Raynaud's phenomenon (PRP).

Methods: The Cochrane Central Register of Controlled Trials, PubMed, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, China Science and Technology Journal Database, and Wanfang Database were searched up to February 13, 2018. Randomized controlled trials (RCTs) on treatment of PRP with Chinese herbal medicine compared with placebo, blank control, lifestyle changes, or calcium antagonists were identified and reviewed. Read More

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http://dx.doi.org/10.19852/j.cnki.jtcm.2020.04.001DOI Listing

Effect of General Anesthesia on Cardiac Magnetic Resonance-Derived Cardiac Function in Repaired Tetralogy of Fallot.

Pediatr Cardiol 2020 Aug 1. Epub 2020 Aug 1.

Department of Research Operations, Cook Children's Medical Center, Fort Worth, TX, USA.

Cardiac magnetic resonance imaging (CMR)-derived ejection fraction (EF) predicts adverse outcomes in repaired tetralogy of Fallot (rTOF) and drives timing of pulmonary valve replacement. Certain patient populations require sedation for successful CMR image acquisition. General anesthesia (GA) has been shown to depress EF and heart rate (HR) in animal models, however, its effect on congenital heart disease is unknown. Read More

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http://dx.doi.org/10.1007/s00246-020-02425-9DOI Listing

[Raynaud phenomenon with arterial thromboses and IgG4-related disease].

Rev Med Interne 2020 Jul 26. Epub 2020 Jul 26.

Service de Dermatologie et Allergologie, Hôpital Tenon, AP-HP, Sorbonne Université, 4 rue de la Chine, 75020 Paris, France. Electronic address:

Introduction: This is a clinical case illustrating a diagnosis of an IgG4 related-disease (IgG4-RD) diagnosed in a vascular context.

Case Report: A 47-year-old man with no past medical history consulted for a recent and disabling Raynaud phenomenon without trophic disorder. Vascular examinations revealed multiple arterial thromboses with no abnormal finger and toe pressures. Read More

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http://dx.doi.org/10.1016/j.revmed.2020.05.008DOI Listing

Raynaud phenomenon of the nipple successfully treated with nifedipine and gabapentin.

Cutis 2020 Jun;105(6):E22-E23

St. Joseph Mercy Hospital, Ann Arbor, Michigan, USA.

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Public interest in Raynaud's phenomenon: A Google Trends analysis.

Dermatol Ther 2020 Jul 16:e14017. Epub 2020 Jul 16.

Department of Dermatology, Peking Union Medical College Hospital, Beijing, China.

Raynaud's phenomenon is a common disorder affecting body extremities and other vascular beds. As infodemiological methods have developed, online search tools could be used to explore the public interest of the disease. The study aimed to determine the annual trend, seasonal pattern, and associated topics of Raynaud's phenomenon. Read More

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http://dx.doi.org/10.1111/dth.14017DOI Listing

Autologous Fat Grafting for the Oral and Digital Complications of Systemic Sclerosis: Results of a Prospective Study.

Aesthetic Plast Surg 2020 Jul 6. Epub 2020 Jul 6.

Rheumatology Unit, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy.

Background: Systemic sclerosis is a connective tissue disease. Skin involvement of the mouth and hand may compromise function and quality of life. Autologous fat grafting has been described as a specific treatment of these clinical features. Read More

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http://dx.doi.org/10.1007/s00266-020-01848-2DOI Listing

Blood biomarkers for vibration-induced white fingers. A case-comparison study.

Am J Ind Med 2020 Sep 29;63(9):779-786. Epub 2020 Jun 29.

Department of Sustainable Health, Umeå University, Umeå, Sweden.

Background: Vibration induced white fingers (VWF) is one form of secondary Raynaud's phenomenon (RP).

Methods: Vibration exposed workers with RP and vibration exposed controls without RP participated. Blood samples were collected before and after cold challenge exposure (COP). Read More

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http://dx.doi.org/10.1002/ajim.23148DOI Listing
September 2020

Is Botulinum Toxin Useful in Systemic Sclerosis Related Peripheral Vasculopathy? A Literature Review.

Reumatol Clin 2020 Jun 23. Epub 2020 Jun 23.

Rheumatology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Rua Conceição Fernandes, 4434-502 Vila Nova de Gaia, Portugal.

Introduction: In systemic sclerosis (SSc), peripheral vasculopathy presents typically as Raynaud Phenomenon (RP) and Digital Ulceration (DU). Over the last decade, botulinum toxin (BT) has been reported effective in this scenario. Our goal was to review existing literature evaluating the efficacy of BT on RP/DU in SSc. Read More

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http://dx.doi.org/10.1016/j.reuma.2020.04.006DOI Listing

Nonaesthetic Applications for Botulinum Toxin in Plastic Surgery.

Plast Reconstr Surg 2020 07;146(1):157-170

New York, N.Y. From the Division of Plastic and Reconstructive Surgery, Department of Surgery, Mount Sinai Hospital.

Background: Since their introduction to clinical medicine in 1989, botulinum toxin injections have been used for many indications. First used for nonsurgical management of strabismus, botulinum toxin injections are now widely used in plastic and reconstructive surgery for aesthetic indications; however, nonaesthetic indications of botulinum toxin have grown tremendously over the past two decades and span numerous specialties, including urology, dermatology, ophthalmology, otolaryngology, gynecology, plastic surgery, general surgery, and neurology. The present review aims to highlight nonaesthetic indications of botulinum toxin that are most relevant to the plastic surgeon with an emphasis on evidence-based practice. Read More

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http://dx.doi.org/10.1097/PRS.0000000000006908DOI Listing

Associations Between Cannabis Use, Abdominal Fat Phenotypes and Insulin Traits.

J Clin Med Res 2020 Jun 4;12(6):377-388. Epub 2020 Jun 4.

School of Medicine, University of Auckland, Auckland, New Zealand.

Background: General obesity has been linked to dysregulation of the endocannabinoid system in humans. However, there is a lack of studies on the relationship between cannabis use and specific abdominal fat phenotypes. The aim was to investigate the associations between cannabis use and magnetic resonance imaging-derived fat phenotypes, as well as indices of insulin sensitivity and insulin secretion. Read More

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http://dx.doi.org/10.14740/jocmr4165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295553PMC

The Effect of Abobotulinum Toxin A on the Symptoms of Raynaud's Phenomenon: A Case Series.

Cureus 2020 May 22;12(5):e8235. Epub 2020 May 22.

Dermatology, University of Central Florida College of Medicine, Orlando, USA.

Raynaud's phenomenon (RP) is a relatively common syndrome occurring alone or in combination with autoimmune and inflammatory diseases. It is characterized by pain and ulceration due to vasospasm in response to cold and stress, most often affecting the digits. Although pharmacologic treatment for this condition exists, it is not always efficacious. Read More

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http://dx.doi.org/10.7759/cureus.8235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306670PMC

Raising rare disease awareness using red flags, role play simulation and patient educators: results of a novel educational workshop on Raynaud phenomenon and systemic sclerosis.

Orphanet J Rare Dis 2020 Jun 23;15(1):159. Epub 2020 Jun 23.

Univ. Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000, Lille, France.

Background: As lack of awareness of rare diseases (RDs) among healthcare professionals results in delayed diagnoses, there is a need for a more efficient approach to RD training during academic education. We designed an experimental workshop that used role-play simulation with patient educators and focused on teaching "red flags" that should raise the suspicion of an RD when faced with a patient with frequently encountered symptoms. Our objective was to report our experience, and to assess the improvement in learners' knowledge and the satisfaction levels of the participants. Read More

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http://dx.doi.org/10.1186/s13023-020-01439-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310378PMC

Paraneoplastic Raynaud phenomenon associated with metastatic ovarian cancer: A case report and review of the literature.

Gynecol Oncol Rep 2020 Aug 26;33:100575. Epub 2020 Apr 26.

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States.

•Paraneoplastic syndromes are rarely associated with ovarian malignancies.•Paraneoplastic syndromes may be the presenting symptom of an underlying malignancy.•Rheumatologic disorders with unusual presentations may be malignancy related. Read More

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http://dx.doi.org/10.1016/j.gore.2020.100575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284054PMC

Factors Associated with Tumor Progression After Percutaneous Ablation of Hepatocellular Carcinoma: Comparison Between Monopolar Radiofrequency and Microwaves. Results of a Propensity Score Matching Analysis.

Cardiovasc Intervent Radiol 2020 Jun 12. Epub 2020 Jun 12.

Department of Radiology, Beaujon Hospital, APHP, University Hospitals Paris Nord Val de Seine, 100 Boulevard du Général Leclerc, 92118, Clichy, Hauts-de-Seine, France.

Purpose: To identify risk factors for local and distant intrahepatic tumor progression after percutaneous ablation of HCC and to compare MWA with monopolar RFA.

Materials And Methods: Consecutive patients with early or very early HCC who underwent percutaneous monopolar RFA or MWA were included. Factors associated with local and distant tumor progression were identified. Read More

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http://dx.doi.org/10.1007/s00270-020-02549-8DOI Listing

Sneddon syndrome: under diagnosed disease, complex clinical manifestations and challenging diagnosis. A case-based review.

Rheumatol Int 2020 Jun 12. Epub 2020 Jun 12.

Department of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL, USA.

Herein, we report a case-based review of the Sneddon Syndrome (SS), a rare chronic condition which affects small to medium blood vessels. It is known by its skin presentation, livedo racemosa (LRC), and the relapsing cerebrovascular events. However, neither LRC nor cerebrovascular events are exclusive to SS. Read More

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http://dx.doi.org/10.1007/s00296-020-04625-1DOI Listing

Phase I trial of the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib and AKT inhibitor capivasertib in patients with BRCA1/2 and non-BRCA1/2 mutant cancers.

Cancer Discov 2020 Jun 12. Epub 2020 Jun 12.

Institute of Cancer Research.

Preclinical studies have demonstrated synergy between poly(ADP-ribose) polymerase (PARP) and phosphatidylinositol-3-kinase (PI3K)/AKT pathway inhibitors in BRCA1 and BRCA2 (BRCA1/2)-deficient and BRCA1/2-proficient tumors. We conducted an investigator-initiated phase I trial utilizing a prospective intrapatient dose-escalation design to assess two schedules of capivasertib (AKT inhibitor) with olaparib (PARP inhibitor) in 64 patients with advanced solid tumors. Dose expansions enrolled germline BRCA1/2-mutant tumors, or BRCA1/2-wildtype cancers harboring somatic DNA damage response (DDR) or PI3K/AKT pathway alterations. Read More

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http://dx.doi.org/10.1158/2159-8290.CD-20-0163DOI Listing

Sclerodermalike syndromes: Great imitators.

Clin Dermatol 2020 Mar - Apr;38(2):235-249. Epub 2019 Oct 24.

Department of Rheumatology and Immunology, University of Pécs Clinical Center, Pecs, Hungary. Electronic address:

Sclerodermalike syndromes (SLSs) comprise diseases with mucin deposition (eg, scleromyxedema, scleredema), with eosinophilia (eg, eosinophilic fasciitis), metabolic or biochemical abnormalities (eg, nephrogenic systemic fibrosis), or endocrine disorders (eg, POEMS syndrome, or polyneuropathy, organomegaly, endocrinopathy, monoclonal lymphoproliferative disorder, and hypothyroidism). Chronic graft-versus-host disease may also show sclerodermalike skin changes. Inherited progeria syndromes with early aging (eg, Werner syndrome) and a heterogeneous group of hereditary disorders with either skin thickening (eg, stiff skin syndrome) or atrophy and tightening (eg, acrogeria) can also imitate classic systemic sclerosis (SSc). Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.10.010DOI Listing
October 2019

Dynamics of digital ulcers in systemic sclerosis.

Exp Ther Med 2020 Jul 27;20(1):61-67. Epub 2020 Feb 27.

Department of Clinical Dermato-Venereology, University of Medicine and Pharmacy 'Gr. T. Popa', Faculty of Medicine and Pharmacy, 700115 Iaşi, Romania.

Systemic sclerosis (SSc) is a collagenosis with insufficiently known etiopathogenesis, characterized by microvasculopathy and excessive fibrosis in the context of an autoimmune disorder. The incompletely elucidated pathogenesis and limited therapeutic options, disabling aspects, skin lesions and pain determine important functional and psychological deficiencies which affect the quality of life. It is imperative to observe and correlate individual clinical and paraclinical data to optimize disease management. Read More

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http://dx.doi.org/10.3892/etm.2020.8572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271728PMC

Different phenotypes in dermatomyositis associated with anti-MDA5 antibody: Study of 121 cases.

Neurology 2020 Jul 2;95(1):e70-e78. Epub 2020 Jun 2.

From the Departments of Clinical Immunology and Internal Medicine (Y.A., S.T., G.L., B.H., N.C., K.M., O.B.), Immunobiology (M.M.), and Biostatistics, Public Health, and Medical Information (B.G.), Pitié-Salpêtrière Hospital, APHP, Sorbonne Universities; Myology Research Centre (Y.A., O.B.), INSERM, UMRS 974, Paris; Department of Pneumology (Y.U., H.N.), APHP, Avicenne Hospital, INSERM U1272, Université Sorbonne Paris Nord, Bobigny; Department of Internal Medicine (L.G., A. Marquet), Lyon Sud Hospital, Lyon Sud University, Paris; Reference Centre for Rare Autoimmune Diseases (A. Meyer) and Medical Intensive Care Unit, Hautepierre Hospital (V. Castelain), Hôpitaux Universitaires de Strasbourg, Strasbourg University; Division of Pneumology (R.B.), Bichat Hospital, AP-HP, Paris-Diderot University, Paris; Department of Pneumology (F.G., P.P.), Centre Hospitalier Universitaire, Angers University; Department of Internal Medicine Infectieuses (C.D.), CHU de Martinique, Fort de France; Departments of Internal Medicine and Clinical Immunology (S.A.) and Internal Medicine and Systemic Diseases (H.D.), François-Mitterrand University Hospital, University of Bourgogne-Franche-Comté, Dijon; Internal Medicine Department (B.T., A.B.), Cochin Hospital, AP-HP, René Descartes University, Paris; Department of Internal Medicine (C.G., N.L.), Henri Mondor Hospital, Paris Est Créteil University, Créteil, France; Department of Neurology (N.V.), Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands; Department of Internal Medicine (E.D.), Hôpital Bretonneau Tours, Tours University; Internal Medicine Department (A.S.), Hôpital Robert-Debré, Reims University; Departments of Rheumatology (T.M.) and Internal Medicine (L.D.S.M.), Bretagne Occidentale University, Centre Hospitalo-Universitaire de Brest; Department of Internal Medicine (S.H.), CHU de Besançon; Department of Internal Medicine (C.B.-D.), Centre Hospitalier Général de Niort; Department of Internal Medicine (N.T.), Nice University, CHU Nice; Department of Internal Medicine (P.C.), Institut Mutualiste Montsouris, Paris; Department of Internal Medicine (M.G.), Jean Verdier Hospital, Paris Seine-Saint-Denis University, Bondy; Department of Internal Medicine (A. Mekinian), Saint Antoine Hospital, APHP, Sorbonne Universities, Paris; Department of Pneumology CHU (J.C.M.), Poitiers University; Department of Pneumology (A.T.), Hôpital Saint-Louis, APHP, Sorbonne Paris Cité, University Paris-Diderot, Paris; Department of Respiratory Medicine (V. Cottin), National Reference Center for Rare Pulmonary Diseases, Hospices Civils de Lyon, Claude Bernard University Lyon 1, Lyon University; Department of Pneumology (D.I.-B.), European George Pompidou Hospital, APHP, Paris V University; Department of Pneumology (S.P.-H.), Sainte-Camille Hospital, Bry-sur-Marne; Department of Pneumology (C.B.), Foch Hospital, Saint Quentin en Yveline University, Suresnes; and Department of Immunology (N.F.), Lyon-Sud Hospital, Hospices Civils-de-Lyon, Pierre-Bénite, France.

Objectives: The predominance of extramuscular manifestations (e.g., skin rash, arthralgia, interstitial lung disease [ILD]) as well as the low frequency of muscle signs in anti-melanoma differentiation-associated gene 5 antibody-positive (anti-MDA5+) dermatomyositis caused us to question the term myositis-specific antibody for the anti-MDA5 antibody, as well as the homogeneity of the disease. Read More

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http://dx.doi.org/10.1212/WNL.0000000000009727DOI Listing

Dynamic CTA and MRA in a case of severe Raynaud's phenomenon.

Clin Imaging 2020 Oct 18;66:133-136. Epub 2020 May 18.

Medical Imaging Department, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia.

Raynaud's phenomenon (RP) is a condition where arterial spasm, usually in the fingers, causes episodes of reduced blood flow. The condition is either idiopathic (primary) or related to a connective tissue disorder or drug response (secondary). We present a case of severe RP where we performed a novel-sequenced CTA and MRA during a prolonged active episode of peripheral vasospasm. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.05.010DOI Listing
October 2020

Cooling-induced dilatation of cutaneous arteries is mediated by increased myoendothelial communication.

Am J Physiol Heart Circ Physiol 2020 Jul 29;319(1):H123-H132. Epub 2020 May 29.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.

Cold exposure causes cutaneous vasoconstriction via a reflex increase in sympathetic activity and a local effect to augment adrenergic constriction. Local cooling also initiates cutaneous dilatation, which may function to restrain cold-induced constriction. However, the underlying mechanisms and physiological role of cold-induced dilatation have not been defined. Read More

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http://dx.doi.org/10.1152/ajpheart.00159.2020DOI Listing

Hepatobiliary MR contrast agents are useful to diagnose hepatocellular carcinoma in patients with Budd-Chiari syndrome.

JHEP Rep 2020 Jun 9;2(3):100097. Epub 2020 Mar 9.

Department of Radiology, APHP, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, France.

Background & Aims: Hepatobiliary phase (HBP) images can discriminate between benign and malignant liver lesions, but it is unclear if this approach can be used in patients with Budd-Chiari syndrome (BCS). Thus, we aimed to assess the diagnostic utility of HBP images in patients with BCS.

Methods: This retrospective study included all patients admitted to our institution with a diagnosis of BCS and focal liver lesions on hepatobiliary contrast agent-enhanced MR imaging (HBCA-MRI) from 2000 to 2019. Read More

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http://dx.doi.org/10.1016/j.jhepr.2020.100097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232085PMC

Mechanical Thrombectomy for Acute Ischemic Stroke Amid the COVID-19 Outbreak: Decreased Activity, and Increased Care Delays.

Stroke 2020 07 20;51(7):2012-2017. Epub 2020 May 20.

Neuroradiology Department, CH Sainte-Anne, Paris, France (B.K., W.B.H., G.B.).

Background And Purpose: The efficiency of prehospital care chain response and the adequacy of hospital resources are challenged amid the coronavirus disease 2019 (COVID-19) outbreak, with suspected consequences for patients with ischemic stroke eligible for mechanical thrombectomy (MT).

Methods: We conducted a prospective national-level data collection of patients treated with MT, ranging 45 days across epidemic containment measures instatement, and of patients treated during the same calendar period in 2019. The primary end point was the variation of patients receiving MT during the epidemic period. Read More

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http://dx.doi.org/10.1161/STROKEAHA.120.030373DOI Listing

Estrogen increases expression of vascular alpha 2C adrenoceptor through the cAMP/Epac/JNK/AP-1 pathway and potentiates cold-induced vasoconstriction.

Vascul Pharmacol 2020 Aug 11;131:106690. Epub 2020 May 11.

Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon; Department of Biomedical Sciences, Qatar University, Doha, Qatar. Electronic address:

Cutaneous cold-induced vasoconstriction is a normal physiological reaction mediated by alpha 2C-adrenergic receptors (α-ARs) expressed in vascular smooth muscle cells (VSMCs). When this reaction is exaggerated, Raynaud's phenomenon (RP) ensues. RP is more prevalent in females compared to age-matched men. Read More

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http://dx.doi.org/10.1016/j.vph.2020.106690DOI Listing

Paraneoplastic Raynaud's phenomenon associated to astrocytoma.

J Med Vasc 2020 May 27;45(3):161-164. Epub 2020 Mar 27.

Internal Medicine Unit, Department of Medico-Surgical Sciences and Biotechnologies, ICOT Hospital, "Sapienza" University of Rome, Via Franco-Faggiana, 1668, 04100 Latina, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jdmv.2020.03.001DOI Listing

Arterial palmar arch occlusion in a woman with Raynaud's disease taking oral combined menopausal hormone therapy: A case report.

Case Rep Womens Health 2020 Jul 21;27:e00206. Epub 2020 Apr 21.

Universidad de Oviedo, La Merced, 22, 2C, 33201 Oviedo, Gijón, Spain.

Patients with surgical menopause often present to their primary care provider with menopausal symptoms. Here we present an unusual case of palmar arch artery occlusion in a 55-year-old woman with primary Raynaud's disease taking oral combined menopausal hormone therapy after surgical menopause for endometriosis. She was successfully treated with intravenous infusion of prostaglandin E1 and nitroglycerin patches over two weeks. Read More

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http://dx.doi.org/10.1016/j.crwh.2020.e00206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191182PMC

Identification and Characterization of Trajectories of Cardiac Allograft Vasculopathy After Heart Transplantation: A Population-Based Study.

Circulation 2020 Jun 4;141(24):1954-1967. Epub 2020 May 4.

Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (R.L., J.K.P., J.K.).

Background: Cardiac allograft vasculopathy (CAV) is a major contributor of heart transplant recipient mortality. Little is known about the prototypes of CAV trajectories at the population level. We aimed to identify the different evolutionary profiles of CAV and to determine the respective contribution of immune and nonimmune factors in CAV development. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.044924DOI Listing

The Use of Ultrasound Guidance for the Treatment of Raynaud Disease of the Hand With Botulinum Toxin.

Ann Plast Surg 2020 Jun;84(6S Suppl 5):S386-S388

From the Departments of Plastic and Maxillofacial Surgery.

Background: This study sought to examine the feasibility and effectiveness of the use of ultrasound (US) as a clinical adjunct in the delivery of botulinum toxin for the treatment of Raynaud disease of the hand.

Methods: One cadaver hand was injected with a colored simulation material using the current traditional surface anatomy approach, whereas an additional cadaver hand was injected using US guidance. The hands were dissected and areas of distribution of the simulation material were evaluated. Read More

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http://dx.doi.org/10.1097/SAP.0000000000002303DOI Listing

Drug repurposing in Raynaud's phenomenon through adverse event signature matching in the World Health Organization pharmacovigilance database.

Br J Clin Pharmacol 2020 Apr 26. Epub 2020 Apr 26.

Inserm CIC1406, clinical pharmacology department, Grenoble Alpes university hospital, Grenoble, France.

Aims: Several pharmacological treatments are recommended for Raynaud's phenomenon (RP) secondary to systemic sclerosis, but they only have modest efficacy. A way to efficiently identify new drugs is drug repurposing, which can be based on signature matching. The signature could be derived from chemical structures, pharmacological affinity or adverse event profiles. Read More

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http://dx.doi.org/10.1111/bcp.14322DOI Listing

Older age onset of systemic sclerosis - accelerated disease progression in all disease subsets.

Rheumatology (Oxford) 2020 Apr 24. Epub 2020 Apr 24.

Department of Dermatology and Venereology, University Hospital Cologne.

Objectives: Systemic sclerosis is a heterogeneous, multisystem disease. It can occur at any age, but most patients develop the disease between the age of 40 to 50 years. There is controversial evidence on whether/how the age at disease onset affects their clinical phenotype. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa127DOI Listing

State-of-the-art technologies provide new insights linking skin and blood vessel abnormalities in SSc-related disorders.

Microvasc Res 2020 07 19;130:104006. Epub 2020 Apr 19.

Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom of Great Britain and Northern Ireland; Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom of Great Britain and Northern Ireland.

Objective: A key unanswered question in systemic sclerosis (SSc) is how microvascular abnormality and fibrosis inter-relate. Our aim was to use state-of-the-art non-invasive imaging methods to gain new insights into pathophysiology, comparing patients with different subtypes of SSc, including early dcSSc, not only to healthy controls but also to patients with causes of Raynaud's phenomenon not progressing to fibrosis.

Methods: Laser Doppler imaging, nailfold capillaroscopy, spectroscopy, and ultrasound measured (respectively) perfusion, microvascular structure, oxygenation/oxidative stress, and skin thickening in the hands of 265 subjects: 31 patients with primary Raynaud's phenomenon (PRP), 35 with undifferentiated connective tissue disease (UCTD), 93 with limited cutaneous SSc (lcSSc), 46 with diffuse cutaneous SSc (dcSSc, including 27 'early') and 60 healthy controls. Read More

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http://dx.doi.org/10.1016/j.mvr.2020.104006DOI Listing

Quizartinib-resistant FLT3-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736.

Blood Adv 2020 Apr;4(7):1478-1491

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, Sutton, United Kingdom.

Internal tandem duplication of FLT3 (FLT3-ITD) is one of the most common somatic mutations in acute myeloid leukemia (AML); it causes constitutive activation of FLT3 kinase and is associated with high relapse rates and poor survival. Small-molecule inhibition of FLT3 represents an attractive therapeutic strategy for this subtype of AML, although resistance from secondary FLT3 tyrosine kinase domain (FLT3-TKD) mutations is an emerging clinical problem. CCT241736 is an orally bioavailable, selective, and potent dual inhibitor of FLT3 and Aurora kinases. Read More

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http://dx.doi.org/10.1182/bloodadvances.2019000986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160287PMC

Safety and feasibility of transradial infrainguinal peripheral arterial disease interventions.

J Vasc Surg 2020 Apr 8. Epub 2020 Apr 8.

Division of Vascular Surgery, The Mount Sinai Medical Center, New York, NY. Electronic address:

Objective: Transradial access (TRA) has traditionally been favored for coronary interventions. Tools with up to 200 cm length now allow operators to treat infrainguinal peripheral arterial disease (PAD) using TRA. This study aims to assess the safety and feasibility of TRA infrainguinal interventions. Read More

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http://dx.doi.org/10.1016/j.jvs.2020.02.016DOI Listing

Reply to "Interdigital injection of botulinum toxin for patients with Raynaud phenomenon".

J Am Acad Dermatol 2020 Mar 31. Epub 2020 Mar 31.

Department of Dermatology, La Paz University Hospital, Madrid, Spain.

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http://dx.doi.org/10.1016/j.jaad.2020.03.066DOI Listing

Reply to: "Interdigital injection of botulinum toxin for patients with Raynaud phenomenon".

J Am Acad Dermatol 2020 Mar 31. Epub 2020 Mar 31.

Department of Hand Surgery and Plastic and Reconstructive Surgery of the Limbs, La Timone University Hospital, Assistance Publique Hôpitaux de Marseille, Marseille, France.

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http://dx.doi.org/10.1016/j.jaad.2020.02.085DOI Listing

[Clinical analysis of 12 cases of mixed connective tissue disease-associated trigeminal neuropathy].

Zhonghua Yi Xue Za Zhi 2020 Mar;100(12):938-941

Department of Rheumatology, People's Hospital of Peking University, Beijing 100044, China.

The aim of present study is to analyze clinical and laboratory features of mixed connective tissue disease (MCTD)-associated trigeminal neuropathy (TN). Clinical records of 12 cases of MCTD complicated with TN diagnosed in Peking University People's Hospital from January 2008 to October 2019 were analyzed retrospectively. The present study included 12 cases, 1 males and 11 females, average age was(40±13)years. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191113-02471DOI Listing

Ischemic ulcers of the toes secondary to Raynaud's phenomenon in a child successfully treated with botulinum toxin.

Pediatr Dermatol 2020 Jul 24;37(4):681-683. Epub 2020 Mar 24.

Department of Dermatology, La Paz University Hospital, Madrid, Spain.

Raynaud's phenomenon (RP) is an episodic vasospastic response to cold or emotional stress causing color changes and pain. These attacks can lead to digital ischemia, ulcers, and gangrene. Severe and refractory RP in children is a therapeutic challenge for clinicians because there are no standardized treatment protocols for these patients. Read More

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http://dx.doi.org/10.1111/pde.14160DOI Listing

Spanish scleroderma risk score (RESCLESCORE) to predict 15-year all-cause mortality in scleroderma patients at the time of diagnosis based on the RESCLE cohort: Derivation and internal validation.

Autoimmun Rev 2020 May 17;19(5):102507. Epub 2020 Mar 17.

Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d'Hebron, Barcelona, Spain.

A few scores predicting the short-term risk of mortality in Systemic sclerosis (SSc) have been reported to date. Our study aimed to create a predictive 15-year all-cause mortality score at the time of the diagnosis of SSc. The study was based on the Spanish Scleroderma Registry (RESCLE). Read More

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http://dx.doi.org/10.1016/j.autrev.2020.102507DOI Listing
May 2020
7.933 Impact Factor

Adverse Health Outcomes Among US Testicular Cancer Survivors After Cisplatin-Based Chemotherapy vs Surgical Management.

JNCI Cancer Spectr 2020 Apr 8;4(2):pkz079. Epub 2019 Oct 8.

Division of Hematology-Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.

We evaluated for the first time, to our knowledge, adverse health outcomes (AHOs) among US testicular cancer survivors (TCS) given chemotherapy (n = 381) vs surgery-only patients (n = 98) managed at a single institution, accounting for non-treatment-related risk factors to delineate chemotherapy's impact. Chemotherapy consisted largely of bleomycin-etoposide-cisplatin (BEP) administered in three or four cycles (BEPx3, n = 235; BEPx4, n = 82). Incidence of at least 3 AHOs was lowest in surgery-only TCS and increased with BEPx3, BEPx4, and other cisplatin-based regimens (12. Read More

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http://dx.doi.org/10.1093/jncics/pkz079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065712PMC

Repeatability of High Resolution Laser Doppler Images of the hands in patients with systemic sclerosis and secondary Raynaud's phenomenon.

Authors:
J Britton

Photodermatol Photoimmunol Photomed 2020 Mar 17. Epub 2020 Mar 17.

Medical Physics Department, Old Medical School, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX.

Objectives: The objective of the study was to establish the repeatability of baseline diagnostic images of the dorsum of the hands acquired using a high resolution Laser Doppler imager in patients with Raynaud's phenomenon secondary to Systemic Sclerosis (SSc).

Methods: The dorsal side of the hands of 22 patients (8 male 14 female) , age range 29-73, median 62, with SSc and secondary Raynaud's phenomenon were imaged over two consecutive days at approximately the same time using a Moor Instruments High Resolution Laser Doppler imaging unit. The images were analysed by taking regions of interest at discrete locations in the images to calculate dimensionless values of flux(PU). Read More

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http://dx.doi.org/10.1111/phpp.12549DOI Listing

The challenge of Very Early Systemic Sclerosis: a Combination of Mild and Early Disease?

J Rheumatol 2020 Mar 15. Epub 2020 Mar 15.

From the Department of Rheumatology, University Hospital Zurich, Zurich Switzerland, Division of Rheumatology, University of Florence, Italy. Address correspondence to Prof. Dr. med. Oliver Distler, University Hospital Zurich, Department of Rheumatology, Gloriastr. 25, CH-8091 Zurich, E-mail:

Objective: To address the hypothesis that very early patients with systemic sclerosis (SSc) are a heterogeneous group of patients with mild or early disease, we analyzed the extent of heterogeneity in clinical, epidemiological and immunological characteristics of these patients.

Methods: We performed an analysis of very early SSc patients from the Zurich cohort, who fulfilled neither the 2013 ACR/EULAR nor the 1980 ACR classification criteria, but had a clinical expert diagnosis of SSc with Raynaud's phenomenon and additional features of SSc (puffy fingers, SSc-specific antibodies, SSc pattern on nailfold-capillaroscopy or any organ involvement characteristic for SSc). Disease duration was defined from first Raynaud`s symptom. Read More

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http://dx.doi.org/10.3899/jrheum.190976DOI Listing

Alexithymia and emotion regulation in patients with Raynaud's disease.

J Clin Psychol 2020 Mar 9. Epub 2020 Mar 9.

Faculty of Public Health, Institute of Behavioural Sciences, University of Debrecen, Debrecen, Hungary.

Objectives: Besides cold, emotional distress is the most important trigger of Raynaud's disease (RD) attacks, although little is known about the factors that contribute to the effectiveness of coping with emotional distress. The aim of the present study was to explore alexithymia and emotion regulation and their relationship with depression and quality of life among patients with RD.

Methods: Total of 110 patients (mean age 53. Read More

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http://dx.doi.org/10.1002/jclp.22947DOI Listing

Scleroderma mimics - Clinical features and management.

Best Pract Res Clin Rheumatol 2020 02 5;34(1):101489. Epub 2020 Mar 5.

Centre for Rheumatology, Royal Free Campus, University College London, Rowland Hill Street, London NW3 2PF, UK. Electronic address:

Systemic sclerosis is a severe immune-mediated rheumatic disease by virtue of its clinical impact and mortality. There are a number of other sclerosing skin diseases that should be considered in the differential diagnosis and these are important because they may require specialist investigation and management. In addition, long-term follow up of the different conditions should reflect the risk of associated complications and anticipated duration of therapy. Read More

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http://dx.doi.org/10.1016/j.berh.2020.101489DOI Listing
February 2020

Clinical features and outcomes of the patients with anti-glycyl tRNA synthetase syndrome.

Clin Rheumatol 2020 Aug 6;39(8):2417-2424. Epub 2020 Mar 6.

Department of Rheumatology, China-Japan Friendship Hospital, Beijing, 100029, China.

Objective: To analyze the clinical features and outcomes of the patients with anti-glycyl tRNA synthetase (anti-EJ) syndrome in a large Chinese cohort.

Methods: The medical records, imaging, and serologic data of patients with anti-EJ antibodies from the China-Japan Friendship Hospital database were retrospectively investigated. Anti-EJ antibodies were identified using immunoblot assay. Read More

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http://dx.doi.org/10.1007/s10067-020-04979-8DOI Listing