7,316 results match your criteria Raynaud Phenomenon


Helicobacter cinaedi associated with atypical Raynaud syndrome.

Clin Microbiol Infect 2019 Jan 10. Epub 2019 Jan 10.

Département de Bactériologie-Virologie, Hygiène et Parasitologie-Mycologie, Centre Hospitalier Régional Universitaire (CHRU) de Brest, 29238 Brest, France; UMR1078 "Génétique, Génomique Fonctionnelle et Biotechnologies", INSERM, Université de Brest, EFS, IBSAM, 29200 Brest, France.

We report a picture of incurvated Gram-negative bacilli corresponding to a Helicobacter cinaedi strain. The strain was isolated from the bloodstream in a woman with atypical Raynaud's disease and a recent history of superficial venous thrombosis. H. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1198743X193000
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http://dx.doi.org/10.1016/j.cmi.2019.01.001DOI Listing
January 2019
1 Read

Juvenile Scleroderma: A Referral Center Experience.

Arch Rheumatol 2018 Sep 18;33(3):344-351. Epub 2018 Jan 18.

Department of Pediatric Rheumatology, İstanbul University, Cerrahpasa Medical School, İstanbul, Turkey.

Objectives: This study aims to evaluate the demographic and clinical features, laboratory data, treatment modalities, and outcomes of juvenile systemic sclerosis (JSS) and juvenile localized scleroderma (JLS) patients at a referral pediatric rheumatology center in Turkey.

Patients And Methods: Medical records of a total of 57 patients, including 29 with JSS (1 male, 28 females; mean age 18.3±3. Read More

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https://www.archivesofrheumatology.org/full-text/948
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http://dx.doi.org/10.5606/ArchRheumatol.2018.6578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328218PMC
September 2018
2 Reads

Progression of immunoglobulin G4-related disease to systematic lupus erythematosus after gastric cancer surgery: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13545

Department of Nephrology, Fujita Health University School of Medicine.

Rationale: Immunoglobulin G4 related disease (IgG4-RD) rarely coexists with other autoimmune diseases, though we had a patient whose primary clinical problem was shifted from IgG4-RD to systemic lupus erythematosus (SLE) after gastrectomy. The present paper aimed to report pathological findings and clinical course of the patient.

Patient Concerns: The patient was a male aged 74 years old with gastric cancer characterized by the following symptoms: Raynaud phenomenon, polyarthralgia, and swollen parotid glands on both sides. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812210-0003
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http://dx.doi.org/10.1097/MD.0000000000013545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320217PMC
December 2018
2 Reads

Extrahepatic Autoimmune Diseases are Prevalent in Autoimmune Hepatitis Patients and Their First-Degree Relatives: Survey Study.

Interact J Med Res 2018 Dec 19;7(2):e18. Epub 2018 Dec 19.

Division of Gastroenterology and Hepatology, Indiana University, Indianapolis, IN, United States.

Background: Concurrent autoimmune illnesses contribute to increased medical burden and reduced quality of life in patients with autoimmune hepatitis (AIH). The frequency of coexisting autoimmune conditions among North American patients with AIH and their families remains incomplete. Challenges associated with disease capture in the electronic medical record, high study costs, and geographic spread of patients are formidable barriers to understanding the extent of concurrent autoimmune conditions in these groups. Read More

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http://dx.doi.org/10.2196/ijmr.9625DOI Listing
December 2018
1 Read

Abnormal Nailfold Capillaroscopy Is Common in Patients with Connective Tissue Disease and Associated with Abnormal Pulmonary Function Tests.

J Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

From the Department of Internal Medicine, Division of Vascular Medicine, and the Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen; Department of Rheumatology, Medical Center Leeuwarden, Leeuwarden, the Netherlands. A.M. van Roon, Department of Internal Medicine, Division of Vascular Medicine, University of Groningen, University Medical Center Groningen; C.C. Huisman, Department of Internal Medicine, Division of Vascular Medicine, University of Groningen, University Medical Center Groningen; A.M. van Roon, PhD, Department of Internal Medicine, Division of Vascular Medicine, University of Groningen, University Medical Center Groningen; D. Zhang, MD, Department of Rheumatology, Medical Center Leeuwarden; A.J. Stel, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; A.J. Smit, MD, PhD, Department of Internal Medicine, Division of Vascular Medicine, University of Groningen, University Medical Center Groningen; H. Bootsma, MD, PhD, Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen; D.J. Mulder, MD, PhD, Department of Internal Medicine, Division of Vascular Medicine, University of Groningen, University Medical Center Groningen. Address correspondence to A.M. van Roon, Department of Internal Medicine, Division of Vascular Medicine, University Medical Center Groningen, Huispostcode AA41, Hanzeplein 1, Postbus 30 001, Groningen, the Netherlands. E-mail: Accepted for publication September 11, 2018.

Objective: To assess the presence of a systemic sclerosis (SSc) pattern on nailfold capillary microscopy (NCM) in patients with Raynaud phenomenon (RP) and to explore its association with abnormal pulmonary function tests (PFT).

Methods: NCM patterns were assessed in 759 consecutive patients with RP. Patterns were classified as normal (n = 354), nonspecific (n = 159), or SSc pattern (n = 246). Read More

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http://dx.doi.org/10.3899/jrheum.180615DOI Listing
December 2018

Microcirculation disorders of the oral cavity in patients with primary Raynaud's Phenomenon.

Pol Arch Intern Med 2018 Dec 13. Epub 2018 Dec 13.

INTRODUCTION Raynaud Phenomenon is a medical condition in which spasm of arteries cause episodes of reduced blood flow. Potential disorders in the microcirculation R2.1a of the oral mucosa may promote the occurrence of lesions. Read More

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http://dx.doi.org/10.20452/pamw.4389DOI Listing
December 2018

Median neuropathy at the wrist in patients with systemic sclerosis: two-year follow-up study.

Reumatologia 2018 31;56(5):294-300. Epub 2018 Oct 31.

Department of Rehabilitation Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Objectives: To determine the incidence and factors associated with median neuropathy at the wrist (MNW) in systemic sclerosis (SSc) patients using an electrodiagnostic (EDX) study.

Material And Methods: SSc patients who attended the scleroderma clinic, Srinagarind Hospital, were prospectively evaluated by questionnaire, physical examination, and EDX study. The questionnaire consisted of the baseline characteristics, type of scleroderma, clinical signs and symptoms associated with scleroderma, and the Boston questionnaire. Read More

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http://dx.doi.org/10.5114/reum.2018.79500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263308PMC
October 2018
2 Reads

[Life-threatening respiratory insufficiency; rare primary manifestation of the antisynthetase syndrome].

Ned Tijdschr Geneeskd 2018 11 27;162. Epub 2018 Nov 27.

Universitaire Ziekenhuizen Leuven, afd. Algemene Interne Geneeskunde, België.

The antisynthetase syndrome (AS) is a rare auto-immune disease characterised by inflammatory myopathies, interstitial lung disease, inflammatory arthritis, Mechanic's Hands and Raynaud phenomenon. AS infrequently presents with life-threatening lung disease as its primary or sole manifestation. By means of two clinical case reports, an overview is given of recent advances in diagnosis and treatment of AS-related interstitial lung disease. Read More

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November 2018
7 Reads

New trends in botulinum toxin use in dermatology.

Dermatol Pract Concept 2018 Oct 31;8(4):277-282. Epub 2018 Oct 31.

Department of Dermatology, University of Campania Luigi Vanvitelli, Naples, Italy.

Background: Recent studies have highlighted new botulinum neurotoxin (BoNT) applications in the field of dermatology.

Objective: To review current knowledge of BoNT use in dermatology.

Methods: The literature of the last 5 five years has been reviewed. Read More

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http://dx.doi.org/10.5826/dpc.0804a05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246063PMC
October 2018
1 Read

Clinical Profile of Primary Sjogrens Syndrome with Hypokalemic Periodic Paralysis.

J Assoc Physicians India 2018 May;66(5):69-70

Chief and Consultant Rheumatologist, Center for Rheumatic Diseases, Pune, Maharashtra.

Introduction: Primary Sjogren's Syndrome (pSS) with Hypokalemic Periodic Paralysis(HPP) whether an association or a different clinical subset needs review.

Methods: Cross-sectional retrospective study of subjects of Primary Sjogren's Syndrome with Hypokalemic Periodic Paralysis(HPP) identified from database maintained at Centre For Rheumatic Diseases, Pune since 1996 with records of over 50000 patients. The diagnosis was clinical. Read More

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May 2018
21 Reads

A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts.

Eur J Hum Genet 2018 Nov 20. Epub 2018 Nov 20.

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE-751 24, Uppsala, Sweden.

Systemic lupus erythematosus (SLE) is an autoimmune disorder with heterogeneous clinical presentation and complex etiology involving the interplay between genetic, epigenetic, environmental and hormonal factors. Many common SNPs identified by genome wide-association studies (GWAS) explain only a small part of the disease heritability suggesting the contribution from rare genetic variants, undetectable in GWAS, and complex epistatic interactions. Using targeted re-sequencing of coding and conserved regulatory regions within and around 215 candidate genes selected on the basis of their known role in autoimmunity and genes associated with canine immune-mediated diseases, we identified a rare regulatory variant rs200395694:G > T located in intron 4 of the MEF2D gene encoding the myocyte-specific enhancer factor 2D transcription factor and associated with SLE in Swedish cohorts (504 SLE patients and 839 healthy controls, p = 0. Read More

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http://dx.doi.org/10.1038/s41431-018-0297-xDOI Listing
November 2018
2 Reads

Acral coldness - severely reduced blood flow to fingers and toes.

Handb Clin Neurol 2018 ;157:677-685

Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. Electronic address:

The term acral coldness is used to describe physiologic or pathologic situations in humans where the fingers and toes are exceptionally cold in spite of normal central body temperature. In the thermoneutral zone, the blood flow to acral skin normally shows large fluctuations between high and low values, with a frequency of about 3 cycles per minute. At an acral skin temperature of about 21°C, finger blood flow is constantly low. Read More

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http://dx.doi.org/10.1016/B978-0-444-64074-1.00040-9DOI Listing
January 2018
9 Reads

A serious case of primary Raynaud's phenomenon in an infant.

Clin Case Rep 2018 Nov 17;6(11):2089-2091. Epub 2018 Sep 17.

Pediatric Emergency Care Kitakyushu Municipal Yahata Hospital Kitakyushu, Fukuoka Japan.

We present a case of severe Raynaud phenomenon (RP) in an infant. The current strategy of RP treatment is incomplete; excluding secondary Raynaud phenomenon is vital as well. This case aims to help those with similar symptoms in the future by gathering data on cases. Read More

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http://dx.doi.org/10.1002/ccr3.1819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230609PMC
November 2018
6 Reads

Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations: Results of a Multicenter International Study.

J Rheumatol 2018 Nov 15. Epub 2018 Nov 15.

From the Rheumatology Unit, Azienda Policlinico of Modena, University of Modena and Reggio Emilia, Modena, Italy; ACURA Rheumatology Center, Bad Kreuznach, Germany; Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDiVAL, University of Cantabria, Santander, Spain; Rheumatology Division, University Hospital of Frankfurt, Frankfurt, Germany; Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas, Mexico City, Mexico; Servicio de Reumatología, Hospital Universitario La Paz, Madrid, Spain; Interdisciplinary Department of Medicine (DIM), Rheumatology Unit, University of Bari, Bari, Italy; Rheumatology Department, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria (IIS) Princesa, Madrid; Unidad de Enfermedades Autoinmunes Sistémicas, Servicio de Medicina Interna, Universidad Autonoma de Barcelona, on behalf of the GEAS group, Barcelona, Spain; Department of Experimental and Clinical Medicine, and Department of Medical and Surgical Critical Care, Section of Dermatology, University of Florence, Florence; Unità Operativa Complessa (UOC) Reumatologia, Ospedale San Camillo-Forlanini, Rome; ACURA Centre for Rheumatic Diseases, Baden-Baden, Germany; Rheumatology Department, Città Della Salute e della Scienza, Torino; Division of Rheumatology, University and Institute for Research and Health Care (IRCCS) Policlinico S. Matteo Foundation, Pavia, Italy; Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Dermatology Clinic, University Hospital of Trieste; Department of Pneumology and Respiratory Intermediate Care Unit, University Hospital of Cattinara, Trieste; Rheumatology Unit, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Trieste, Trieste, Italy; Medizinische Klinik A, Klinikum der Stadt, Ludwigshafen, Germany; Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, San Martino Polyclinic Hospital IRCCS Genoa, Genoa, Italy; Interstitial and Rare Lung Disease Unit, Ruhrlandklinik University Hospital, University of Duisburg-Essen, Essen, Germany; UOC Reumatologia, Azienda Ospedaliero Universitaria S. Anna, University of Ferrara, Italy; Department for Rheumatology and Clinical Immunology, St. Josef Krankenhaus, University Clinic, Essen, Germany; Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa; Department of Internal Medicine, Rheumatology and Clinical Immunology, University Hospital Johannes-Gutenberg, Mainz, Germany; University of Ghent, Ghent University Hospital, Ghent, Belgium. M. Sebastiani, MD, Rheumatology Unit, Azienda Policlinico of Modena, University of Modena and Reggio Emilia; A. Manfredi, MD, Rheumatology Unit, Azienda Policlinico of Modena, University of Modena and Reggio Emilia; G. Cassone, MD, Rheumatology Unit, Azienda Policlinico of Modena, University of Modena and Reggio Emilia; K. Triantafyllias, MD, ACURA Rheumatology Center; A. Schwarting, MD, Professor, ACURA Rheumatology Center; M.A. González-Gay, MD, Professor, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDiVAL, University of Cantabria; N. Palmou-Fontana, MD, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDiVAL, University of Cantabria; U. Drott, MD, Rheumatology Division, University Hospital of Frankfurt; C. Delbrück, MD, Rheumatology Division, University Hospital of Frankfurt; J. Rojas-Serrano, MD, Professor, Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas; C. Bertolazzi, MD, Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas; L. Nuño, MD, Servicio de Reumatología, Hospital Universitario La Paz; M. Giannini, MD, DIM, Rheumatology Unit, University of Bari; F. Iannone, MD, Professor, DIM, Rheumatology Unit, University of Bari; E.F. Vicente, MD, Rheumatology Department, Hospital Universitario de la Princesa, IIS Princesa; S. Castañeda, MD, Professor, Rheumatology Department, Hospital Universitario de la Princesa, IIS Princesa; A. Selva-O'Callaghan, MD, Professor, Unidad de Enfermedades Autoinmunes Sistémicas, Servicio de Medicina Interna, Universidad Autonoma de Barcelona, on behalf of the GEAS group; E. Trallero Araguas, MD, Unidad de Enfermedades Autoinmunes Sistémicas, Servicio de Medicina Interna, Universidad Autonoma de Barcelona, on behalf of the GEAS group; G. Emmi, MD, Department of Experimental and Clinical Medicine, University of Florence; A. Iuliano, MD, UOC Reumatologia, Ospedale San Camillo-Forlanini; J. Bauhammer, MD, ACURA Centre for Rheumatic Diseases; N. Miehle MD, ACURA Centre for Rheumatic Diseases; S. Parisi, MD, Rheumatology Department, Città Della Salute e della Scienza; L. Cavagna, MD, Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation; V. Codullo, MD, Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation; C. Montecucco, MD, Professor, Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation; F.J. Lopez-Longo, MD, Servicio de Reumatología, Hospital General Universitario Gregorio Marañón; J. Martínez-Barrio, MD, Servicio de Reumatología, Hospital General Universitario Gregorio Marañón; J.C. Nieto-González, MD, Servicio de Reumatología, Hospital General Universitario Gregorio Marañón; S. Vichi, MD, Dermatology Clinic, University Hospital of Trieste; M. Confalonieri, MD, Department of Pneumology and Respiratory Intermediate Care Unit, University Hospital of Cattinara; P. Tomietto MD, Rheumatology Unit, Azienda Ospedaliero-Universitaria Ospedali Riuniti; R. Bergner, MD, Professor, Medizinische Klinik A, Klinikum der Stadt; A. Sulli, MD, Professor, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, San Martino Polyclinic Hospital IRCCS Genoa; M. Cutolo, MD, Professor, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, San Martino Polyclinic Hospital IRCCS Genoa; F. Bonella, MD, Interstitial and Rare Lung Disease Unit, Ruhrlandklinik University Hospital, University of Duisburg-Essen; F. Furini, MD, UOC Reumatologia, Azienda Ospedaliero Universitaria S. Anna, University of Ferrara; C.A. Scirè, MD, Associate Professor, UOC Reumatologia, Azienda Ospedaliero Universitaria S. Anna, University of Ferrara; A. Bortoluzzi, MD, UOC Reumatologia, Azienda Ospedaliero Universitaria S. Anna, University of Ferrara; C. Specker, MD, Professor, Department for Rheumatology and Clinical Immunology, St. Josef Krankenhaus, University Clinic; S. Barsotti, MD, Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa; R. Neri, MD, Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa; M. Mosca, MD, Professor, Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa; M. Caproni, MD, Department of Medical and Surgical Critical Care, Section of Dermatology, University of Florence; J. Weinmann-Menke, MD, Department of Internal Medicine, Rheumatology and Clinical Immunology, University Hospital Johannes-Gutenberg; A. Schwarting, MD, Professor, Department of Internal Medicine, Rheumatology and Clinical Immunology, University Hospital Johannes-Gutenberg; V. Smith, MD, Professor, University of Ghent, Ghent University Hospital. Dr. Sebastiani and Dr. Triantafyllias contributed equally to this article. Address correspondence to Dr. K. Triantafyllias, ACURA Rheumatology Center, Bad Kreuznach, Germany. E-mail: Accepted for publication August 13, 2018.

Objective: To describe nailfold videocapillaroscopy (NVC) features of patients with antisynthetase syndrome (AS) and to investigate possible correlations with clinical and serological features of the disease.

Methods: We retrospectively analyzed NVC images of 190 patients with AS [females/males 3.63, mean age 49. Read More

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http://www.jrheum.org/lookup/doi/10.3899/jrheum.180355
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http://dx.doi.org/10.3899/jrheum.180355DOI Listing
November 2018
12 Reads

Systemic features of retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations: a monogenic small vessel disease.

J Intern Med 2018 Nov 8. Epub 2018 Nov 8.

Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.

Background: Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a small vessel disease caused by C-terminal truncating TREX1 mutations. The disease is typically characterized by vascular retinopathy and focal and global brain dysfunction. Systemic manifestations have also been reported but not yet systematically investigated. Read More

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http://doi.wiley.com/10.1111/joim.12848
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http://dx.doi.org/10.1111/joim.12848DOI Listing
November 2018
5 Reads

On-Demand Sildenafil as a Treatment for Raynaud Phenomenon: A Series of n-of-1 Trials.

Ann Intern Med 2018 Nov 30;169(10):694-703. Epub 2018 Oct 30.

Université Grenoble Alpes and Grenoble Alpes University Hospital, Grenoble, France (M.R., O.G., C.K., M.M., A.L., S.B., C.S., A.P., C.C., B.I., P.C., J.C.).

Background: Treatment of Raynaud phenomenon (RP) with phosphodiesterase-5 inhibitors has shown moderate efficacy. Adverse effects decrease the risk-benefit profile of these drugs, and patients may not be willing to receive long-term treatment. On-demand single doses before or during exposure to cold may be a good alternative. Read More

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http://annals.org/article.aspx?doi=10.7326/M18-0517
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http://dx.doi.org/10.7326/M18-0517DOI Listing
November 2018
61 Reads
19.384 Impact Factor

PBC and related extrahepatic diseases.

Best Pract Res Clin Gastroenterol 2018 Jun - Aug;34-35:49-54. Epub 2018 May 23.

Dept. of Surgery, Oncology and Gastroenterology, University of Padova, Italy.

Patients with PBC have at least 60% of probability to have an autoimmune extrahepatic condition. The pathogenesis of these conditions includes a common mechanism involving both innate and adaptive immune responses targeting cholangiocytes and different extrahepatic tissues. The recent EASL guidelines recommend the management of these conditions, although detailed practical treatments have not been indicated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216918183000
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http://dx.doi.org/10.1016/j.bpg.2018.05.013DOI Listing
December 2018
7 Reads

Aggressiveness of Localized Prostate Cancer: the Key Value of Testosterone Deficiency Evaluated by Both Total and Bioavailable Testosterone: AndroCan Study Results.

Horm Cancer 2019 Feb 6;10(1):36-44. Epub 2018 Oct 6.

Department of Urology, Hôpital Foch, University of Versailles-Saint-Quentin-en-Yvelines, 40 Rue Worth, 92150, Suresnes, France.

Failure rates after first-line treatment of localized prostate cancer (PCa) treatment remain high. Improvements to patient selection and identification of at-risk patients are central to reducing mortality. We aimed to determine if cancer aggressiveness correlates with androgen levels in patients undergoing radical prostatectomy for localized PCa. Read More

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http://link.springer.com/10.1007/s12672-018-0351-8
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http://dx.doi.org/10.1007/s12672-018-0351-8DOI Listing
February 2019
12 Reads

Long-term neurotoxicity and raynaud's phenomenon in patients treated with cisplatin-based chemotherapy for malignant ovarian germ cell tumor.

Acta Obstet Gynecol Scand 2018 Oct 5. Epub 2018 Oct 5.

National Resource Centre for Late Effects after Cancer Treatment, Oslo University Hospital, Norwegian Radium Hospital, Oslo, Norway.

Introduction: The aim was to evaluate "overall neuropathy", defined as peripheral paresthesias and Raynaud's phenomenon, in long-term survivors of malignant ovarian germ cell tumors (MOGCTs) treated with cisplatin-based chemotherapy (CBCT) MATERIAL AND METHODS: Ninety-three MOGCT survivors recorded in Norway in 1980-2009 (median follow-up: 15 years) were included in this analysis. Forty-nine received CBCT (CBCT group) and 44 received other or no chemotherapy (non-CBCT group). Applying the scale for chemotherapy-induced neurotoxicity, the prevalence of overall neuropathy (i. Read More

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http://dx.doi.org/10.1111/aogs.13477DOI Listing
October 2018
1 Read

Botulinum Toxin Injection for Lower Face and Oral Cavity Raynaud Phenomenon After Mandibulectomy, Free Fibula Reconstruction, and Radiation Therapy.

Ann Plast Surg 2019 Jan;82(1):53-54

Department of Plastic Surgery, MD Anderson Cancer Center, Houston, TX.

Isolated lingual and lower face Raynaud phenomenon without primary Raynaud of the digits is a very rare condition associated with chemoradiation therapy (RT) in previous reports. The condition, which more commonly presents in patients with a history of Raynaud disease, is often self-limiting, but vasodilating agents and steroids have been suggested as possible treatment options. Spasmodic torticollis is a different, more common entity, also associated with history of RT or previous head and neck surgery. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001622DOI Listing
January 2019
6 Reads

Lisdexamfetamine and Secondary Raynaud's Phenomenon.

Authors:
Sundar Gnanavel

Prim Care Companion CNS Disord 2018 Sep 13;20(5). Epub 2018 Sep 13.

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http://dx.doi.org/10.4088/PCC.17l02240DOI Listing
September 2018
1 Read

Riociguat for the Treatment of Raynaud's Phenomenon: A Single-Dose, Double-Blind, Randomized, Placebo-Controlled Cross-Over Pilot Study (DIGIT).

Clin Drug Investig 2018 Nov;38(11):1061-1069

Clinic III for Internal Medicine, Department of Cardiology, Heart Center, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

Background And Objective: Raynaud's phenomenon (RP) is characterized by transient digital ischemia and is commonly associated with connective tissue disease. Treatment remains unsatisfactory. Here we evaluate the efficacy, safety, and pharmacokinetics of a single dose of the soluble guanylate cyclase stimulator riociguat in RP. Read More

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http://dx.doi.org/10.1007/s40261-018-0698-1DOI Listing
November 2018
5 Reads

Advances in Upper Extremity Scleroderma Wound Care.

Adv Skin Wound Care 2018 Oct;31(10):446-455

Joshua M. Cohen, MD • Resident Physician • New York University School of Medicine • Hansjörg Wyss Department of Plastic Surgery • NYU Langone Health • New York, New York Rachel A. Sibley, MD • Resident Physician • New York University School of Medicine • Department of Internal Medicine • NYU Langone Health • New York, New York Ernest S. Chiu, MD, FACS • Associate Professor • Hansjörg Wyss Department of Plastic Surgery • NYU Langone Health • New York, New York Sheel Sharma, MD • Clinical Associate Professor • Hansjörg Wyss Department of Plastic Surgery • NYU Langone Health • New York, New York.

General Purpose: To provide information about the pathophysiology, diagnosis, and treatment options for systemic sclerosis.

Target Audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

Learning Objectives/outcomes: After participating in this educational activity, the participant should be better able to:1. Read More

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http://dx.doi.org/10.1097/01.ASW.0000544615.18501.fdDOI Listing
October 2018
1 Read
1.630 Impact Factor

Effect of topical rosemary essential oil on Raynaud phenomenon in systemic sclerosis.

Complement Ther Med 2018 Oct 1;40:191-194. Epub 2017 Nov 1.

ARCIM Institute, Filderklinik, Filderstadt, Germany; Department of Pediatrics, University Hospital Tübingen, Germany.

Introduction: Raynaud's phenomenon is the earliest manifestation of systemic sclerosis. Nitroglycerin gel is the only proven topical therapy.

Methods: A 53-year-old woman with systemic sclerosis had topical Rosamarinus officinalis (rosemary) oil, often used in anthroposophic medicine, applied to her hands over 3days and then, separately, olive oil. Read More

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http://dx.doi.org/10.1016/j.ctim.2017.10.012DOI Listing
October 2018
11 Reads

[Hypothenar hammer syndrome: A recurrent case report after surgery].

J Med Vasc 2018 Sep 24;43(5):320-324. Epub 2018 Aug 24.

Service de chirurgie de la main, chirurgie plastique et reconstructrice de l'appareil locomoteur, CHU de Nancy, centre chirurgical Emile-Gallé, 49, rue Hermite, 54000 Nancy, France. Electronic address:

Hypothenar hammer syndrome is a rare entity secondary to ulnar artery damage in the wrist, affecting mainly those exposed to repeated hand-palm trauma. Surgery is discussed in case of severe symptoms, resistant to medical treatment, and/or when anatomical lesions with emboligenic potential are demonstrated in the radiological exams. In this case, resection of the pathological zone with revascularization by autologous vein graft is the best option. Read More

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http://dx.doi.org/10.1016/j.jdmv.2018.06.002DOI Listing
September 2018
1 Read

Photoacoustic Oxygenation Quantification in Patients with Raynaud's: First-in-Human Results.

Ultrasound Med Biol 2018 10 6;44(10):2081-2088. Epub 2018 Jul 6.

Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA.

The purpose of this study was to investigate the use of photoacoustic imaging for quantifying fingertip oxygenation as an approach to diagnosing and monitoring Raynaud's phenomenon. After 30 min of acclimation to room temperature, 22 patients (7 patients with secondary Raynaud's associated to Scleroderma and 15 healthy controls) provided informed consent to undergo fingertip Doppler imaging and high-frequency photoacoustic imaging before and 5, 15 and 30 min after cold stimulus (submerged hand in a 15 °C water bath for 1 min). High-frequency ultrasound and photoacoustic imaging was performed on the nail bed of each patient's second through fifth finger on their dominant hand, using a Vevo 2100 LAZR system with an LZ-250 probe (Fujifilm VisualSonics, Toronto, ON, Canada) in oxy-hemoglobin quantification mode. Read More

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http://dx.doi.org/10.1016/j.ultrasmedbio.2018.04.017DOI Listing
October 2018
13 Reads

High burden of skin sclerosis is associated with severe organ involvement in patients with systemic sclerosis and systemic sclerosis overlap syndrome.

Rheumatol Int 2018 Sep 11. Epub 2018 Sep 11.

Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.

The objective of this study is to investigate the impact of skin sclerosis burden on an internal organ involvement over a 1-year period, as measured by time-adjusted accrual-modified Rodnan skin score (TA-mRSS), and to evaluate association between TA-mRSS patterns and laboratory tests in patients with systemic sclerosis (SSc). This prospective study was conducted at Siriraj Hospital (Bangkok, Thailand) during the November 2013-November 2016. SSc patients by ACR/EULAR 2013 or ACR 1980 criteria were eligible. Read More

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http://dx.doi.org/10.1007/s00296-018-4156-4DOI Listing
September 2018
2 Reads

[Digital necrosis revealing cold agglutinin disease: Treatment with rituximab].

Ann Dermatol Venereol 2018 Dec 7;145(12):761-764. Epub 2018 Sep 7.

Service de dermatologie et allergologie, université Pierre-et-Marie-Curie, Paris VI, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France.

Background: Digital necrosis is rarer than lower limb necrosis and constitutes a medical or surgical emergency. Etiological evaluation is required. Cold agglutinin disease is a cause of digital necrosis but diagnosis is difficult. Read More

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http://dx.doi.org/10.1016/j.annder.2018.07.010DOI Listing
December 2018
18 Reads

A Phenotype of Primary Open-angle Glaucoma With Systemic Vasospasm.

J Glaucoma 2018 Nov;27(11):987-992

Glaucoma Division, Jules Stein Eye Institute, University of California Los Angeles (UCLA), Los Angeles, CA.

Purpose: Primary open-angle glaucoma (POAG) patients constitute a heterogenous group. Identification of phenotypic subtypes among these patients may provide a deeper understanding of the disease and aid associations with genotypes. We describe a phenotype of POAG patients associated with a constellation of systemic disorders; patients with this phenotype seem to be vulnerable to optic nerve damage at low intraocular pressures. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001083DOI Listing
November 2018
12 Reads

Evolving symptoms of Raynaud's phenomenon in systemic sclerosis are associated with physician and patient-reported assessments of disease severity.

Arthritis Care Res (Hoboken) 2018 Aug 21. Epub 2018 Aug 21.

University of Utah and Salt Lake Regional Veterans Affair Medical Center, Salt Lake City, Utah, United States of America.

Objectives: Assessment of Raynaud's phenomenon (RP) in systemic sclerosis (SSc) is reliant on self-report. The Raynaud's Condition Score (RCS) diary assumes discrete episodic RP attacks, although not all SSc patients identify with this paradigm. We investigated the clinical associations of SSc-RP symptom characteristics and evolution of SSc-RP symptoms with disease progression. Read More

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http://dx.doi.org/10.1002/acr.23729DOI Listing
August 2018
3 Reads

Association of skin hyperpigmentation disorders with digital ulcers in systemic sclerosis: Analysis of a cohort of 239 patients.

J Am Acad Dermatol 2019 Feb 7;80(2):478-484. Epub 2018 Aug 7.

Department of Dermatology, National Reference Center for Rare Skin Disorders, Hôpital Saint-André, CHU de Bordeaux, Bordeaux, France; Inserm U1035, Biothérapie des Maladies Génétiques et Cancers, University of Bordeaux, Bordeaux, France. Electronic address:

Background: Skin pigmentation disorders in systemic sclerosis (SSc) have been sparsely described in the literature. Nevertheless, they could be a diagnostic and/or severity marker.

Objectives: To assess the association between pigmentation disorders and systemic involvement in patients with SSc. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.07.033DOI Listing
February 2019
5 Reads

[Cold and White - Hypothenar Hammer Syndrome].

Authors:
Ewelina Biskup

Praxis (Bern 1994) 2018 Aug;107(16):912-916

1 Shanghai University of Medicine and Health Sciences, Shanghai, P.R. China.

Cold and White - Hypothenar Hammer Syndrome Abstract. Hypothenar hammer syndrome (HHS) is a condition caused by digital ischemia as a result of repeated trauma to the little finger. Routine diagnosis should include a detailed medical history and a physical examination including Allen's test. Read More

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http://dx.doi.org/10.1024/1661-8157/a003046DOI Listing
August 2018
2 Reads

The march of pluripotent stem cells in cardiovascular regenerative medicine.

Stem Cell Res Ther 2018 Jul 27;9(1):201. Epub 2018 Jul 27.

Department of Biological and Environmental Sciences, Qatar University, Doha, Qatar.

Cardiovascular disease (CVD) continues to be the leading cause of global morbidity and mortality. Heart failure remains a major contributor to this mortality. Despite major therapeutic advances over the past decades, a better understanding of molecular and cellular mechanisms of CVD as well as improved therapeutic strategies for the management or treatment of heart failure are increasingly needed. Read More

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http://dx.doi.org/10.1186/s13287-018-0947-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062943PMC
July 2018
16 Reads

Evaluation of Serum Vitamin D Levels in Patients with Systemic Sclerosis and Healthy Controls: Results of a Pilot Study.

Indian Dermatol Online J 2018 Jul-Aug;9(4):250-255

Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra, Tanda, Himachal Pradesh, India.

Background: The anti-inflammatory, immunomodulatory, and anti-proliferative effects of vitamin D in pathogenesis of autoimmune diseases have been highlighted in recent years but implications of vitamin D deficiency in systemic sclerosis (SSc) remain understudied.

Objectives: To evaluate serum vitamin D levels in SSc patients and matched controls.

Materials And Methods: Serum vitamin D levels were estimated in 38 (M:F 5:33) patients aged 23-70 years of untreated SSc and age and gender matched healthy controls. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_328_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042194PMC
July 2018
3 Reads

Raynaud's phenomenon: Current concepts.

Clin Dermatol 2018 Jul - Aug;36(4):498-507. Epub 2018 Apr 10.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA. Electronic address:

Raynaud's phenomenon (RP) is a transient, acral, vasospastic phenomenon that manifests with characteristic color changes. This vasospasm, classically triggered by cold temperatures, may also be driven by shifts in temperature, climate, or emotional state. Primary RP (PRP) is a common condition without severe sequelae. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2018.04.007DOI Listing
December 2018
7 Reads

Systemic sclerosis: Current concepts of skin and systemic manifestations.

Clin Dermatol 2018 Jul - Aug;36(4):459-474. Epub 2018 Apr 12.

Corporal Michael J. Crescenz VAMC, Philadelphia, Pennsylvania, USA; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Systemic sclerosis is an uncommon autoimmune connective tissue disease with multiorgan system involvement and significant associated morbidity and mortality. Cutaneous signs and clinical manifestations are of particular importance, as they may be recognized before systemic manifestations, allowing earlier risk stratification into the limited and diffuse cutaneous subtypes, as well as earlier initiation of treatment. Important cutaneous manifestations include Raynaud's phenomenon, digital ulcers, cutaneous sclerosis, calcinosis cutis, telangiectasias, pruritus, and dyspigmentation. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2018.04.004DOI Listing
December 2018
11 Reads

Rheumatologic dermatology.

Authors:
Drew Kurtzman

Clin Dermatol 2018 Jul - Aug;36(4):439-441

Division of Dermatology, St. Elizabeth Physicians, University of Louisville School of Medicine, 7370 Turfway Road, Suite 370, Florence, KY 41042. Electronic address:

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http://dx.doi.org/10.1016/j.clindermatol.2018.05.002DOI Listing
December 2018
1 Read

Hypothenar hammer syndrome: A case of a late complication after surgery.

Hand Surg Rehabil 2018 Oct 21;37(5):316-319. Epub 2018 Jul 21.

Service de chirurgie de la main, chirurgie plastique et reconstructrice de l'appareil locomoteur, centre chirurgical Émile-Gallé, CHU de Nancy, 49, rue Hermite, 54000 Nancy, France. Electronic address:

Hypothenar hammer syndrome is a rare condition secondary to ulnar artery damage in Guyon's canal, affecting mainly those exposed to repeated palm trauma. Surgery is discussed in cases of severe symptoms that are resistant to conservative treatment, and/or when anatomical lesions with high embolism potential are discovered during imaging exams. Resection of the pathological zone with revascularization by autologous vein graft is the best option. Read More

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http://dx.doi.org/10.1016/j.hansur.2018.07.001DOI Listing
October 2018
1 Read

Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus in a patient with progressive systemic sclerosis.

Lupus 2018 Oct 20;27(11):1860-1863. Epub 2018 Jul 20.

3 Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

A 60-year-old female was diagnosed with progressive systemic sclerosis and interstitial lung disease of two months' duration. The patient was treated for Raynaud phenomenon with aspirin, nifedipine, colchicine, and naproxen. Two weeks after treatment, she developed widespread erythematous patches with blistering eruptions on the face, torso, and extremities, and also had erosion on the oral mucosa. Read More

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http://dx.doi.org/10.1177/0961203318789766DOI Listing
October 2018
2 Reads

Clinical Presentation and Long-Term Outcomes of Systemic Sclerosis Portuguese Patients from a Single Centre Cohort: A EUSTAR Registration Initiative.

Acta Med Port 2018 Jun 29;31(6):312-320. Epub 2018 Jun 29.

Serviço de Medicina Interna. Hospital do Divino Espírito Santo de Ponta Delgada. São Miguel. Portugal.

Introduction: Systemic sclerosis is a complex disorder that requires systematic screening. Our objective is to report the European Scleroderma Trials and Research group centre affiliation and its impact in our clinical practice.

Material And Methods: The European Scleroderma Trials and Research group affiliation process, database update and current patient evaluation, with respect to demographic and clinical features. Read More

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http://dx.doi.org/10.20344/amp.10658DOI Listing
June 2018
4 Reads

Autoimmune associations in a Mexican cohort with primary biliary cholangitis.

Rev Gastroenterol Mex 2018 Jul 13. Epub 2018 Jul 13.

Departamento de Reumatología, Centro Médico ISSEMyM, Metepec, México.

Introduction: Several groups have reported associations of primary biliary cholangitis with other autoimmune entities, particularly Sjögren's syndrome and hypothyroidism. Its prevalence and characteristics in Mexican patients is unknown.

Aim: To determine the frequency and characteristics of autoimmune diseases in a Mexican cohort of patients with primary biliary cholangitis. Read More

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http://dx.doi.org/10.1016/j.rgmx.2018.03.008DOI Listing
July 2018
3 Reads

Proton pump inhibitors and Raynaud's phenomenon: is there a link?

Br J Clin Pharmacol 2018 Oct 12;84(10):2443-2444. Epub 2018 Jul 12.

Clinical Pharmacology Department, Grenoble Alpes University Hospital, Grenoble, France.

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http://dx.doi.org/10.1111/bcp.13697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138507PMC
October 2018
16 Reads

Herbal Medicines for Cold Hypersensitivity in the Hands and Feet: A Systematic Review and Meta-Analysis.

J Altern Complement Med 2018 Jul 11. Epub 2018 Jul 11.

5 Department of Preventive Medicine, Wonju College of Medicine, Yonsei University , Wonju, Republic of Korea.

Objectives: Cold hypersensitivity in the hands and feet (CHHF) and Raynaud's phenomenon (RP) are prevalent among Asian populations, especially among women, who exhibit a higher rate of cold hypersensitivity that may be associated with gynecological problems. In several countries, herbal medicine has effectively treated cold hypersensitivity symptoms. This systematic review and meta-analysis of the literature was undertaken to evaluate the efficacy of herbal medicine for the treatment of CHHF in adults. Read More

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http://dx.doi.org/10.1089/acm.2018.0009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308292PMC
July 2018
6 Reads

Expression of the oxygen-sensitive transcription factor subunit HIF-1α in patients suffering from secondary Raynaud syndrome.

Acta Pharmacol Sin 2018 Jul 10. Epub 2018 Jul 10.

Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Freiburg, 79106, Germany.

Anti-ischemic therapy remains a challenge due to the complexity of hypoxia response pathways. Hypoxia-inducible factor (HIF)-1 is a heterodimer transcription factor consisting of 2 subunits, HIF-1α and HIF-1β. Hypoxia-dependent activation of HIF-1α regulates cellular O homeostasis. Read More

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http://dx.doi.org/10.1038/s41401-018-0055-1DOI Listing
July 2018
6 Reads

Imaging studies of kleptomania in a middle-aged woman with obsessive-compulsive disorder: a case report.

Psychogeriatrics 2018 Sep 10;18(5):430-433. Epub 2018 Jul 10.

Department of Psychiatry, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

A 57-year-old woman who had been arrested for shoplifting visited our hospital. She was diagnosed with kleptomania. She had previously been diagnosed with CREST (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) syndrome and obsessive-compulsive disorder. Read More

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http://dx.doi.org/10.1111/psyg.12339DOI Listing
September 2018
25 Reads

The mechanism of botulinum A on Raynaud syndrome.

Drug Des Devel Ther 2018 26;12:1905-1915. Epub 2018 Jun 26.

Department of Neurology, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.

Background: Botulinum neurotoxin type A (BoNT/A) is emerging as a treatment modality for Raynaud's phenomenon (RP). However, the mechanism of the role of BoNT/A in antagonizing the constriction of arteriola in RP remains unclear.

Materials And Methods: We tested the constriction of arteriole diameter and the distribution of adrenergic receptors on the rat cremaster modle. Read More

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http://dx.doi.org/10.2147/DDDT.S161113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027706PMC
October 2018
4 Reads

Evidence of macro- and micro-angiopathy in scleroderma: An integrated approach combining 22-MHz power Doppler ultrasonography and video-capillaroscopy.

Microvasc Res 2019 Mar 6;122:125-130. Epub 2018 Jul 6.

Division of Rheumatology, ASST Pini-CTO, Milano, Italy; Dept of Clinical Sciences & Community Health, Università degli Studi di Milano, Milano, Italy. Electronic address:

Objective: We aimed to study in SSc patients macrovascular involvement by using power Doppler ultrasound (PDUS) and microvascular one by PDUS and nailfold video-capillaroscopy (NVC) and to examine the association between history of digital ulcers (HDU) and imaging (PDUS and NVC) parameters.

Methods: NVC and PDUS were systematically performed in 106 consecutive SSc patients at the 3rd and 4th finger of the dominant hand after exclusion of ulnar artery occlusion (UAO). 22 MHz PDUS measurements included nailbed and fingertip qualitatively graded, and resistivity index (RI) of ulnar and radial proper digital arteries. Read More

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http://dx.doi.org/10.1016/j.mvr.2018.07.001DOI Listing
March 2019
3 Reads

Systemic therapy with calcitonin has positive clinical effects on systemic sclerosis in patients with cutaneous manifestations.

Eur J Dermatol 2018 Jun;28(3):364-369

Friedrich-Alexander-Universität of Erlangen-Nürnberg, Universitätsklinikum Erlangen, Department of Dermatology, Ulmenweg 18, D-91054 Erlangen, Germany.

Background: Calcitonin gene-related peptide (CGRP) is a vasodilatory neuropeptide that plays an important role in the blood vessels of heart and peripheral circulation, a lack of which may cause vasculopathies.

Objective: In this study, the clinical course of disease, as well as the efficacy, side effects, and patient satisfaction of systemic calcitonin therapy in patients with systemic sclerosis (SSc), was evaluated.

Methods: Forty-nine patients received repetitive intravenous calcitonin infusions as first-line treatment. Read More

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http://dx.doi.org/10.1684/ejd.2018.3300DOI Listing
June 2018
10 Reads