4,869 results match your criteria Rathke Cleft Cyst


Sellar Pathologies Mimicking Pituitary Tumors.

Neurol India 2020 May-Jun;68(Supplement):S154-S160

Department of Neurosurgery, Bombay Hospital Institute of Medical Sciences, Mumbai, Maharashtra, India.

The most common sellar pathology that merits neurosurgical attention is the pituitary adenoma. However, some developmental, inflammatory, and neoplastic lesions may primarily or secondarily involve the sella, mimicking pituitary tumors. Advances in imaging and endocrinological assessment have helped in the recognition of these less common sellar, supra sellar pathologies, which may occasionally create confusion in management. Read More

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http://dx.doi.org/10.4103/0028-3886.287682DOI Listing

Bilateral pediatric pial arteriovenous fistulas accompanying a giant arachnoid cyst with torticollis: A case report.

Medicine (Baltimore) 2020 Jun;99(26):e20991

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.

Rationale: Pial arteriovenous fistula (PAVF) occurs when intracranial arteries communicate directly with veins. PAVFs are very rare congenital vascular lesions that are commonly seen in infants and children. Arachnoid cysts are congenital cavitation often filled with cerebrospinal fluid. Read More

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http://dx.doi.org/10.1097/MD.0000000000020991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328906PMC
June 2020
5.723 Impact Factor

Von Hippel-Lindau syndrome and renal tumours: radiological diagnostic and treatment options. A case report and literature review.

Acta Med Litu 2020 ;27(1):25-32

National Cancer Institute, Vilnius, Lithuania.

Background: Von Hippel-Lindau disease (VHL) is a rare autosomal dominant syndrome diagnosed for 1 out of 36000-45000 newborns and 90% of the patients have a clinical manifestation before 65 years of age. Affected individuals have an increased risk of developing tumours in several organs or their systems. The most common tumours are retinal or central nervous system hemangioblastomas (60-80%) and VHL-associated renal lesions. Read More

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http://dx.doi.org/10.6001/actamedica.v27i1.4263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305806PMC
January 2020

Machine-Learning Classifiers in Discrimination of Lesions Located in the Anterior Skull Base.

Front Oncol 2020 28;10:752. Epub 2020 May 28.

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.

The aim of this study was to investigate the diagnostic value of machine-learning models with radiomic features and clinical features in preoperative differentiation of common lesions located in the anterior skull base. A total of 235 patients diagnosed with pituitary adenoma, meningioma, craniopharyngioma, or Rathke cleft cyst were enrolled in the current study. The discrimination was divided into three groups: pituitary adenoma vs. Read More

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http://dx.doi.org/10.3389/fonc.2020.00752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270197PMC

Neurocysticercosis Presenting as an Isolated Suprasellar Lesion: Case Report.

World Neurosurg 2020 Jun 6. Epub 2020 Jun 6.

Department of Neurological Surgery, University of Virginia Health System, Charlottesville, VA 22908. Electronic address:

Background: Although extraparenchymal Neurocysticercosis (NCC) is well established, presentation in the suprasellar space is rare. When presenting in the suprasellar space, the imaging characteristics may mimic more common lesions including craniopharyngioma and Rathke cleft cyst depending on the life cycle of the parasite. Although antiparasitic medical therapy may be effective for viable NCC, it is not routinely employed for calcified NCC. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.212DOI Listing

Megalencephalic Leukoencephalopathy with Subcortical Cysts Disease-Linked MLC1 Protein Favors Gap-Junction Intercellular Communication by Regulating Connexin 43 Trafficking in Astrocytes.

Cells 2020 Jun 8;9(6). Epub 2020 Jun 8.

Department of Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

Astrocytes, the most numerous cells of the central nervous system, exert critical functions for brain homeostasis. To this purpose, astrocytes generate a highly interconnected intercellular network allowing rapid exchange of ions and metabolites through gap junctions, adjoined channels composed of hexamers of connexin (Cx) proteins, mainly Cx43. Functional alterations of Cxs and gap junctions have been observed in several neuroinflammatory/neurodegenerative diseases. Read More

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http://dx.doi.org/10.3390/cells9061425DOI Listing

Hemangioblastoma and von Hippel-Lindau disease: genetic background, spectrum of disease, and neurosurgical treatment.

Childs Nerv Syst 2020 Jun 7. Epub 2020 Jun 7.

Department of Neurosurgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany.

Introduction: Hemangioblastomas are rare, histologically benign, highly vascularized tumors of the brain, the spinal cord, and the retina, occurring sporadically or associated with the autosomal dominant inherited von Hippel-Lindau (VHL) disease. Children or adults with VHL disease have one of > 300 known germline mutations of the VHL gene located on chromosome 3. They are prone to develop hemangioblastomas, extremely rarely starting at age 6, rarely at age 12-18, and, typically and almost all, as adults. Read More

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http://dx.doi.org/10.1007/s00381-020-04712-5DOI Listing

How often do we incidentally find a fetal abnormality at the routine third-trimester growth scan? A population-based study.

Am J Obstet Gynecol 2020 Jun 3. Epub 2020 Jun 3.

Nuffield Department of Women's and Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, UK. Electronic address:

Background: Third-trimester scans are increasingly used to try to prevent adverse outcomes associated with abnormalities of fetal growth. Unexpected fetal malformations detected at third-trimester growth scans are rarely reported.

Objective: To determine the incidence and type of fetal malformations detected in women attending a routine third-trimester growth scan. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.05.052DOI Listing

Diabetes Insipidus After Endoscopic Transsphenoidal Surgery.

Neurosurgery 2020 Jun 5. Epub 2020 Jun 5.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: Diabetes insipidus (DI) is a recognized transient or permanent complication following transsphenoidal surgery (TSS) for pituitary tumors.

Objective: To describe significant experience with the incidence of DI after TSS, identifying predictive characteristics and describing our diagnosis and management of postoperative DI.

Methods: A retrospective analysis was performed of 700 patients who underwent endoscopic TSS for resection of pituitary adenoma (PA), Rathke cleft cyst (RCC), or craniopharyngioma. Read More

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http://dx.doi.org/10.1093/neuros/nyaa148DOI Listing

Headache in Ruptured Intracranial Dermoid Cysts.

Curr Pain Headache Rep 2020 May 29;24(7):31. Epub 2020 May 29.

Yale University School of Medicine, New Haven, CT, USA.

Purpose Of Review: Intracranial dermoid cysts are benign, rare mass-occupying lesions of the central nervous system arising from the neuroectodermal cell lines. While rupture of intracranial dermoid cysts is rare, it can present with a variety of clinical manifestations. To explore the headache manifestations among patients with ruptured intracranial dermoid cysts. Read More

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http://dx.doi.org/10.1007/s11916-020-00863-xDOI Listing

Isoniazid Conjugated Magnetic Nanoparticles Loaded with Amphotericin B as a Potent Antiamoebic Agent against .

Antibiotics (Basel) 2020 May 25;9(5). Epub 2020 May 25.

Department of Biology, Chemistry and Environmental Sciences, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, UAE.

The pathogenic free-living amoeba, , is responsible for a rare but deadly central nervous system infection, granulomatous amoebic encephalitis and a blinding eye disease called keratitis. Currently, a combination of biguanides, amidine, azoles and antibiotics are used to manage these infections; however, the host cell cytotoxicity of these drugs remains a challenge. Furthermore, species are capable of transforming to the cyst form to resist chemotherapy. Read More

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http://dx.doi.org/10.3390/antibiotics9050276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277095PMC

Pathological and Incidental Findings in 403 Taiwanese Girls With Central Precocious Puberty at Initial Diagnosis.

Front Endocrinol (Lausanne) 2020 5;11:256. Epub 2020 May 5.

Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Whether girls with central precocious puberty (CPP) should undergo routine brain magnetic resonance imaging (MRI) to identify potential intracranial pathologies is controversial. To evaluate the brain MRI results of girls with CPP and identify the clinical and endocrine predictors of brain abnormalities. This retrospective study obtained data from pediatric endocrine clinics at Chang Gung Children's Hospital. Read More

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http://dx.doi.org/10.3389/fendo.2020.00256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214687PMC

Aging with Toxoplasma gondii results in pathogen clearance, resolution of inflammation, and minimal consequences to learning and memory.

Sci Rep 2020 May 14;10(1):7979. Epub 2020 May 14.

BIO5 Institute, University of Arizona, Tucson, Arizona, United States.

Persistent inflammation has been identified as a contributor to aging-related neurodegenerative disorders such as Alzheimer's disease. Normal aging, in the absence of dementia, also results in gradual cognitive decline and is thought to arise, in part, because of a chronic pro-inflammatory state in the brain. Toxoplasma gondii is an obligate intracellular parasite that establishes a persistent, asymptomatic infection of the central nervous system (CNS) accompanied by a pro-inflammatory immune response in many of its hosts, including humans and rodents. Read More

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http://dx.doi.org/10.1038/s41598-020-64823-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224383PMC

Dynamic Changes in the Global Transcriptome and MicroRNAome Reveal Complex miRNA-mRNA Regulation in Early Stages of the Bi-Directional Development of Protoscoleces.

Front Microbiol 2020 9;11:654. Epub 2020 Apr 9.

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Background: Cystic echinococcosis is a life-threatening disease caused by the larval stages of the dog tapeworm . Protoscoleces (PSCs) of this worm have the ability of bi-directional development to either larval cysts or strobilar adult worms. However, the molecular mechanisms underlying this development process are unknown. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188192PMC
April 2020
3.941 Impact Factor

Analysis of U8 snoRNA Variants in Zebrafish Reveals How Bi-allelic Variants Cause Leukoencephalopathy with Calcifications and Cysts.

Am J Hum Genet 2020 05 30;106(5):694-706. Epub 2020 Apr 30.

Division of Evolution and Genomic Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK. Electronic address:

How mutations in the non-coding U8 snoRNA cause the neurological disorder leukoencephalopathy with calcifications and cysts (LCC) is poorly understood. Here, we report the generation of a mutant U8 animal model for interrogating LCC-associated pathology. Mutant U8 zebrafish exhibit defective central nervous system development, a disturbance of ribosomal RNA (rRNA) biogenesis and tp53 activation, which monitors ribosome biogenesis. Read More

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http://dx.doi.org/10.1016/j.ajhg.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212298PMC

[Analysis of a child with megalencephalic leukoencephalopathy with subcortical cyst type 2B caused by HEPACAM variant].

Authors:
Min Xu Bo Jin Hu Guo

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 May;37(5):543-546

Department of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, China.

Objective: To explore the clinical features and genetic variant in a child featuring megalencephalic leukoencephalopathy with subcortical cyst (MLC) type 2B.

Methods: Clinical and imaging data of the child was collected. Potential variant of hepatocyte adhesion molecule (HEPACAM) gene was detected by Sanger sequencing. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2020.05.012DOI Listing

Neurenteric cysts at foramen magnum in children: presentation, imaging characteristics, and surgical management-case series and literature review.

Childs Nerv Syst 2020 Jul 23;36(7):1379-1384. Epub 2020 Apr 23.

Department of Neurosurgery, University of Iowa Hospitals & Clinics, Stead Family Children's Hospital, 200 Hawkins Drive, 1824 JPP, Iowa City, IA, 52242, USA.

Introduction: Neurenteric cysts (NEC) are rare benign tumors of the central nervous system. Even more rare are the NEC at the ventral foramen magnum in children that are misdiagnosed. They cause distortion of the vertebrobasilar vascular system and cervicomedullary neural structures and are adherent to the latter. Read More

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http://dx.doi.org/10.1007/s00381-020-04604-8DOI Listing

Arachnoid cysts on magnetic resonance imaging: just an incidental finding?

J Laryngol Otol 2020 May 17;134(5):424-430. Epub 2020 Apr 17.

Department of Otorhinolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK.

Objective: To determine the clinical significance of arachnoid cysts.

Methods: The scans of 6978 patients undergoing magnetic resonance imaging of the internal acoustic meatus for unilateral cochleovestibular symptoms were retrospectively reviewed. We identified the scans with arachnoid cysts, and assessed the statistical associations between the laterality, location and size of the arachnoid cyst, the laterality of symptoms, the patients' age and gender. Read More

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http://dx.doi.org/10.1017/S0022215120000808DOI Listing

Foetal onset of EIF2B related disorder in two siblings: cerebellar hypoplasia with absent Bergmann glia and severe hypomyelination.

Acta Neuropathol Commun 2020 Apr 15;8(1):48. Epub 2020 Apr 15.

Normandie Univ, UNIROUEN, INSERM U1245, Rouen University Hospital, Department of Pathology, F76000, Rouen, France.

Bi-allelic pathogenic variants in genes of the EIF2B family are responsible for Childhood Ataxia with Central nervous system Hypomyelination/Vanishing White Matter disease, a progressive neurodegenerative disorder of the central white matter. Only seven molecularly proven cases with antenatal onset have been reported so far. We report for the first time the neuropathological findings obtained from two foetuses harbouring deleterious variants in the EIF2B5 gene who presented in utero growth retardation and microcephaly with simplified gyral pattern that led to a medical termination of the pregnancy at 27 and 32 weeks of gestation. Read More

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http://dx.doi.org/10.1186/s40478-020-00929-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161274PMC

Epidemiological characteristics of hepatic echinococcosis, concurrent cerebral echinococcosis, and pulmonary echinococcosis in Ganzi County, Sichuan Province, China.

Medicine (Baltimore) 2020 Apr;99(15):e19753

Radiology, The First People's Hospital of Lognquanyi District, Chengdu, Sichuan, China.

Human echinococcosis has become a major public health problem in most parts of the world. The objective of this article was to study the demographics of patients with hepatic echinococcosis in Ganzi County to elucidate the main risk factors, as well as to report the concurrent prevalence of cerebral echinococcosis and pulmonary echinococcosis.We recruited 195 patients with hepatic echinococcosis from the Datongma area of Ganzi County from January 2018 to November 2018. Read More

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http://dx.doi.org/10.1097/MD.0000000000019753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220390PMC

Rathke Cleft Cysts with Apoplexy-Like Symptoms: Clinicoradiologic Comparisons with Pituitary Adenomas with Apoplexy.

World Neurosurg 2020 Mar 23. Epub 2020 Mar 23.

Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Guro, Seoul, South Korea.

Background: Rathke cleft cyst (RCC) can cause acute symptoms mimicking pituitary adenoma (PA) apoplexy. We evaluated the clinicoradiologic features for distinguishing RCC from PA apoplexy.

Methods: We retrospectively evaluated 22 patients with RCC and 24 patients with PA with apoplexy-like symptoms who underwent surgery via a transsphenoidal approach between November 1999 and December 2016. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.03.086DOI Listing

AP4B1-associated hereditary spastic paraplegia: expansion of phenotypic spectrum related to homozygous p.Thr387fs variant.

J Appl Genet 2020 May 12;61(2):213-218. Epub 2020 Mar 12.

Department of Medical Genetics, Medical University of Warsaw, ul. Pawinskiego 3c, 02-106, Warsaw, Poland.

Biallelic mutations in the AP4B1 gene, encoding adaptor-related protein complex 4 beta-1 subunit, have been recognized as an important cause of a group of conditions leading to adaptor-related protein complex 4 (AP4)-associated hereditary spastic paraplegia (SPG47). We describe a homozygous, known variant c.1160_1161delCA (p. Read More

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http://dx.doi.org/10.1007/s13353-020-00552-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148264PMC

Symptomatic hemiparkinsonism due to extensive middle and posterior fossa arachnoid cyst: case report.

BMC Neurol 2020 Mar 12;20(1):89. Epub 2020 Mar 12.

Department of Neurology, Medical University Innsbruck, Anichstrasse 35, Innsbruck, Austria.

Introduction: Intracranial neoplasms are an uncommon cause of symptomatic parkinsonism. We here report a patient with an extensive middle and posterior fossa arachnoid cyst presenting with parkinsonism that was treated by neurosurgical intervention.

Methods: Retrospective chart review and clinical examination of the patient. Read More

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http://dx.doi.org/10.1186/s12883-020-01670-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069038PMC

[Analysis of misdiagnosis causes of suprasellar arachnoid cysts].

Zhonghua Yi Xue Za Zhi 2020 Mar;100(8):610-613

Department of Neurosurgery, Hebei Genral Hospital, Shijiazhuang 050051, China.

To investigate the causes of misdiagnosis of suprasellar arachnoid cysts, analyze its characteristics and put forward the diagnostic basis and differential points. The clinical data fo 97 cases of suprasellar arachnoid cysts diagnosed and treated in the neurosurgery department of Beijing Tiantan Hospital and Hebei General Hospital from March 2015 to March 2019 were analyzed retrospectively. All patients underwent CT and MRI scans with obstructive hydrocephalus. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2020.08.009DOI Listing

Recurrent Spinal Intramedullary Arachnoid Cyst: Case Report and Literature Review.

World Neurosurg 2020 06 3;138:68-72. Epub 2020 Mar 3.

Department of Neurosurgery, Kanazawa University, Kanazawa, Ishikawa, Japan.

Background: Symptomatic intramedullary arachnoid cysts are rarely observed lesions, particularly in the pediatric age group. Treatment includes cyst fenestration or resection of the cyst wall, and recurrence after surgery has never been reported. We report a rare case of a spinal intramedullary arachnoid cyst, which recurred after cyst fenestration and required reoperation after a certain period. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.02.106DOI Listing

Succinylated Wheat Germ Agglutinin Colocalizes with the Toxoplasma gondii Cyst Wall Glycoprotein CST1.

mSphere 2020 03 4;5(2). Epub 2020 Mar 4.

Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA

The glycosylated mucin domain of the cyst wall glycoprotein CST1 is heavily stained by agglutinin, a lectin that binds to -acetylgalactosamine. The cyst wall is also heavily stained by the chitin binding lectin succinylated wheat germ agglutinin (s-WGA), which selectively binds to acetylglucosamine-decorated structures. Here, we tracked the localization of acetylglucosamine-decorated structures that bind to s-WGA in immature and mature cysts. Read More

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http://dx.doi.org/10.1128/mSphere.00031-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056803PMC

Secondary Pituitary Abscess Inside Adenoma: A Case Report and Review of Literature.

World Neurosurg 2020 May 17;137:281-285. Epub 2020 Feb 17.

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

Background: Pituitary abscesses within pre-existing pituitary conditions, such as craniopharyngioma, pituitary adenoma, or Rathke cleft cyst, are quite rare. A case of pituitary abscess secondary to adenoma is presented, and the literature is reviewed.

Case Description: An 11-year-old boy presented with a 3-day history of sudden-onset headache and visual loss. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.02.057DOI Listing

Clinical performance of fixed-pressure Sphera Duo® hydrocephalus shunt.

Arq Neuropsiquiatr 2020 01;78(1):9-12

Universidade de São Paulo, Hospital das Clínicas, Instituto de Psiquiatria, Divisão de Neurocirurgia Funcional, Grupo de Hidrodinâmica Cerebral, São Paulo SP, Brazil.

Introduction: Cerebral hydrodynamics complications in shunted patients are due to the malfunction of the system. The objective of this retrospective, single-center, single-arm cohort study is to confirm the safety and performance of Sphera® Duo when used in adult patients suffering from hydrocephalus, pseudotumor cerebri or arachnoid cysts.

Methods: Data were generated by reviewing 112 adult patient's charts, who were submitted to a ventriculoperitoneal shunt surgery and followed for one year after surgery. Read More

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http://dx.doi.org/10.1590/0004-282X20190135DOI Listing
January 2020

Too Much on Your "Plate"? Spectrum of Pathologies Involving the Tectal Plate.

Can Assoc Radiol J 2020 May 27;71(2):186-194. Epub 2020 Jan 27.

Department of Radiology, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.

The tectal plate comprises the posterior portion of the midbrain, borders the quadrigeminal cistern, and includes the superior and inferior colliculi. Benign and malignant pathologies occurring in this location may lead to aqueductal stenosis, obstructive hydrocephalus, and Parinaud syndrome. Both computed tomography and magnetic resonance imaging can be used to further characterize lesions involving the tectal plate. Read More

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http://dx.doi.org/10.1177/0846537119888410DOI Listing

Keyhole Microsurgical Middle Fossa Arachnoid Cyst Fenestration: 2-Dimensional Operative Video.

World Neurosurg 2020 05 5;137:93. Epub 2020 Feb 5.

Department of Neurological Surgery, University of California, San Diego, La Jolla, California, USA. Electronic address:

Surgical options for symptomatic intracranial arachnoid cysts include cyst shunting and microscopic or endoscopic fenestration. We advocate a microsurgical keyhole approach for the durable fenestration of middle fossa arachnoid cysts, taking advantage of the superior magnification, depth perception, and illumination of the operating microscope, as well as the ability to use bimanual surgical technique and variable suction to ensure safe manipulation of arachnoid membranes and fenestration of these lesions into the deep cisterns. Key technical aspects of this approach demonstrated in this video (Video 1) include performance of a dime-sized temporal craniotomy; strict microsurgical technique with sharp dissection via a No. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.01.222DOI Listing

Proton Magnetic Resonance Spectroscopy Characterization of Rathke's Cleft Cysts (RCCs): Relevance to the Differential Diagnosis of Pituitary Adenomas and RCCs.

Cancers (Basel) 2020 Feb 4;12(2). Epub 2020 Feb 4.

Kenneth R. Peak Brain and Pituitary Tumor Treatment Center, Department of Neurosurgery, Houston Methodist Neurological Institute, Houston Methodist Hospital and Research Institute, Houston, TX 77030, USA.

Background: Rathke's Cleft Cysts (RCCs) are rare epithelial cysts arising from remnants of the Rathke pouch in the pituitary gland. A subset of these lesions enlarge and produce a mass effect with consequent hypopituitarism, and may result in visual loss. Moreover, some RCCs with a high intra-cystic protein content may mimic cystic pituitary adenoma, which makes their differential diagnosis ambiguous. Read More

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http://dx.doi.org/10.3390/cancers12020360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072267PMC
February 2020

Discovery and Optimization of Triazine Nitrile Inhibitors of Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS.

ACS Chem Neurosci 2020 Feb 18. Epub 2020 Feb 18.

Vahlteich Medicinal Chemistry Core, College of Pharmacy , University of Michigan , Ann Arbor , Michigan 48109 , United States.

With roughly 2 billion people infected, the neurotropic protozoan remains one of the most pervasive and infectious parasites. infection is the second leading cause of death due to foodborne illness in the United States, causes severe disease in immunocompromised patients, and is correlated with several cognitive and neurological disorders. Currently, no therapies exist that are capable of eliminating the persistent infection in the central nervous system (CNS). Read More

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http://dx.doi.org/10.1021/acschemneuro.9b00674DOI Listing
February 2020

Approaching the Sella through the Nonpneumatized Sphenoid in Pediatric Patients.

J Neurol Surg B Skull Base 2020 Feb 18;81(1):56-61. Epub 2019 Feb 18.

University of California, San Diego School of Medicine, La Jolla, California, United States.

 The purpose of this study is to specifically assess pediatric patients with nonpneumatized sphenoid sinuses who have undergone transsphenoidal resections of skull base tumors and assess the complications and outcomes.  Data was collected by a retrospective chart review done on children ages 7 and under who underwent endoscopic tumor resection and had a partially or completely nonpneumatized sphenoid sinus on preoperative computed tomography imaging. Surgical data collected included surgical corridor, gross total versus subtotal resection, repair method, use of septal flap, intraoperative and postoperative cerebrospinal fluid leak, and estimated blood loss. Read More

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http://dx.doi.org/10.1055/s-0039-1679895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996996PMC
February 2020

Spontaneous Resolution of Dorsal Midbrain Syndrome Caused by a Pineal Cyst.

World Neurosurg 2020 Apr 27;136:289-292. Epub 2020 Jan 27.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Kensington Vision and Research Centre, Toronto, Ontario, Canada. Electronic address:

Background: Pineal lesions are common causes of dorsal midbrain syndrome and typically require surgical intervention in symptomatic patients. We describe a unique case of spontaneous resolution of dorsal midbrain syndrome resulting from a pineal gland cyst.

Case Description: A 23-year-old woman developed a supranuclear upgaze palsy, convergence-retraction nystagmus, and light-near dissociation from a pineal gland cyst (1. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.01.144DOI Listing

Flying with Colloid Cyst: A Cautionary Note.

World Neurosurg 2020 06 27;138:84-88. Epub 2020 Jan 27.

Department of Neurosurgery, Government Medical College, Thiruvananthapuram, Kerala, India.

Background: Colloid cysts are benign and rare tumors of the brain. The growth rates of these tumors are unpredictable. These cysts can increase in size and obstruct the cerebrospinal fluid pathways producing obstructive hydrocephalus. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.01.124DOI Listing

Burkitt's lymphoma nodular cystic hepatosplenic, in HIV patient. Case report

Rev Med Inst Mex Seguro Soc 2019 05 2;57(3):187-190. Epub 2019 May 2.

Instituto Mexicano del Seguro Social. Hospital General de Zona No. 2. Servicio de Medicina Interna. Cárdenas, Tabasco, México

Background: Patients with human immunodeficiency virus (HIV) are more likely to develop cancer. Malignant lymphomas are the main cancer group seen in these patients. Diffuse large B-cell lymphoma including central nervous system lymphoma and Burkitt's lymphoma account for 90% of HIV-related non-Hodgkin's lymphomas. Read More

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Gas containing intraspinal synovial cyst in the lumbar spine: Case report and literature review.

J Clin Neurosci 2020 Feb 23;72:449-451. Epub 2020 Jan 23.

Department of Orthopedic Surgery, Osaka Medical College, Takatsuki, Japan.

Intraspinal synovial cyst (ISC) is a well-documented pathology. It is sometimes found in the degenerative lumbar spine and can result in neurological disorders. ISC typically contains xanthochromic fluid, blood, inflammatory tissue, and/or osseous structures, enclosed by fibrous tissue. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.01.047DOI Listing
February 2020

T10-L3 Cystic Lesion of the Ventriculus Terminalis Presenting as Conus Medullaris Syndrome.

World Neurosurg 2020 Apr 16;136:146-149. Epub 2020 Jan 16.

Department of Neurologic Surgery, Mayo Clinic, Jacksonville, Florida, USA. Electronic address:

Background: Intramedullary spinal cord cysts are benign, rare, fluid-filled lesions that can present anywhere along the craniospinal axis. However, when present at the level of the ventriculus terminalis, conus medullaris syndrome may occur. Radical resection of the cyst wall and evacuation of the cyst content are the 2 surgical procedures of choice. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.01.049DOI Listing
April 2020
2.417 Impact Factor

Prevalence of Rathke cleft cysts in children on magnetic resonance imaging.

Diagn Interv Imaging 2020 Apr 14;101(4):209-215. Epub 2020 Jan 14.

Department of Radiology, Musculoskeletal Unit, CHRU Besançon, 25030 Besançon, France.

Purpose: The purposes of this study were to estimate the prevalence of Rathke cleft cysts (RCC) in a pediatric population on brain MRI, to describe their appearance, and to estimate interobserver agreement in the detection of RCC.

Materials And Methods: The brain MRI examinations of 460 children were retrospectively reviewed by two radiologists for the presence of RCC. There were 223 boys and 237 girls with a mean age of 8. Read More

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http://dx.doi.org/10.1016/j.diii.2019.12.005DOI Listing

Stereotactic Radiation as Salvage Therapy for Recurrent Rathke Cleft Cysts.

Neurosurgery 2020 Jan 13. Epub 2020 Jan 13.

Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Background: Rathke cleft cysts (RCCs) are sellar-based cystic lesions that are often found incidentally but occasionally become symptomatic with significant visual and/or endocrine deficits. The standard of treatment is surgery, but rare cases of multiply recurrent RCCs can be refractory to surgical drainage, leading to significant morbidity.

Objective: To demonstrate the safety and feasibility of fractionated stereotactic radiotherapy (SRT) as salvage therapy in multiply recurrent RCCs refractory to surgical drainage. Read More

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http://dx.doi.org/10.1093/neuros/nyz523DOI Listing
January 2020

New Insights into the Anterior Complex.

Fetal Diagn Ther 2020 13;47(6):514-518. Epub 2020 Jan 13.

Fetal Medicine Unit - Maternal and Child Health and Development Network, Department of Obstetrics and Gynecology, University Hospital 12 de Octubre, 12 de Octubre Research Institute (imas12), Complutense University of Madrid, Madrid, Spain.

Objective: To introduce visualization of the germinal matrix (GM), external angle of the frontal horn, and periventricular white matter while evaluating the anterior complex (AC) during basic ultrasound assessment of the fetal brain.

Case Presentations: This is a retrospective observational study of healthy women with singleton pregnancies, with no increased risk of fetal central nervous system anomalies, attending routine ultrasound screening at 20-32 weeks' gestation. Seventeen cases are presented in which an abnormal aspect of the GM or external angle of the frontal horn or periventricular white matter on AC evaluation has allowed a prenatal diagnosis of peri-intraventricular hemorrhage, subependymal cysts, connatal cysts, periventricular venous hemorrhagic infarction, and white matter injury. Read More

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http://dx.doi.org/10.1159/000504980DOI Listing
January 2020

Meet in the middle: a technique for resecting nasocranial dermoids-technical note and review of the literature.

Childs Nerv Syst 2020 Mar 10;36(3):477-484. Epub 2020 Jan 10.

Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Introduction: Nasal dermoids with intracranial extension are benign lesions that can have life-threatening consequences, as a nasal punctum may serve as a portal of entry for infection into the central nervous system. The surgical management of these lesions can be challenging, as the extracranial and intracranial cysts and sinus tract must be resected to prevent recurrence, and the surgery must be carried out with an acceptable esthetic result.

Technique: The authors present a technique for the resection of nasocranial dermoids that eliminates the need to remove and replace the frontonasal segment. Read More

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http://dx.doi.org/10.1007/s00381-020-04499-5DOI Listing

MRI and pathological features of Rathke cleft cysts in the sellar region.

Exp Ther Med 2020 Jan 3;19(1):611-618. Epub 2019 Dec 3.

Department of Neurosurgery, Fuzhou General Hospital, Fujian Medical University, Fuzhou, Fujian 350025, P.R. China.

The aim of the present study was to investigate the MRI and pathological features of Rathke cleft cysts (RCC) in the sellar region. A total of 45 RCC cases were retrospectively analyzed. RCC size, location, intracyst nodules and general signals, as well as the posterior pituitary bright spot (PPBS) were analyzed using MRI-T1 weighted images (T1WI) and T2WI. Read More

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http://dx.doi.org/10.3892/etm.2019.8272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923755PMC
January 2020

Surgical management of sacral meningeal cysts by obstructing the communicating holes with muscle graft.

BMC Musculoskelet Disord 2019 Dec 30;20(1):635. Epub 2019 Dec 30.

Department of Orthopaedics, Second Affiliated Hospital of Xi'an Jiaotong University, 157th West Fifth Road, Xi'an, 710004, Shaanxi Province, China.

Background: The surgical indication and treatment of sacral meningeal cyst have not been well established and current methods are usually accompanied by complications and recurrence. The aim of this study is to discuss the treatment of symptomatic sacral meningeal cyst, by investigating the surgical results of our surgically treated patients, and minimize the complications and recurrence.

Methods: We retrospectively reviewed all patients with symptomatic sacral meningeal cysts who were surgically treated by a single surgeon in the same institution from 2002 to 2017. Read More

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http://dx.doi.org/10.1186/s12891-019-2998-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937820PMC
December 2019
1.898 Impact Factor

Progressively Enlarged Convexity Arachnoid Cysts in Elderly Patients: A Report of 2 Cases.

World Neurosurg 2020 Mar 27;135:253-258. Epub 2019 Dec 27.

Department of Neurosurgery, Kanazawa University, Graduate School of Medical Science, Kanazawa, Japan.

Background: Generally, enlargement of arachnoid cysts (ACs) has been found mostly in cases occurring during early childhood. Therefore, progressively enlarged ACs found to be symptomatic in elderly patients are extremely rare, and the mechanisms have remained unexplored.

Case Description: Our first patient was a 72-year-old woman with memory disturbance, who had presented with a large cyst beneath the right temporal convexity 9 years previously. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.12.112DOI Listing

Tension Pneumoventricle After Endoscopic Transsphenoidal Surgery for Rathke Cleft Cyst.

World Neurosurg 2020 Mar 19;135:228-232. Epub 2019 Dec 19.

Division of Neurosurgery, China Medical University Hospital, Taichung, Taiwan; China Medical University, Taichung, Taiwan.

Background: Tension pneumoventricle is an extremely rare, but treatable, neurosurgical emergency. The prompt and accurate diagnosis of tension pneumoventricle requires vigilance for the detection of clinical signs, which should also be corroborated by the imaging findings. We have reported on the pathophysiology of tension pneumoventricle and its management. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.12.065DOI Listing

Usefulness of Contrast-Enhanced 3D-FLAIR MR Imaging for Differentiating Rathke Cleft Cyst from Cystic Craniopharyngioma.

AJNR Am J Neuroradiol 2020 01 19;41(1):106-110. Epub 2019 Dec 19.

From the Departments of Radiology (M.A., Z.A.K., T.H.) and.

Background And Purpose: Because it can be difficult to discriminate between a Rathke cleft cyst and cystic craniopharyngioma by conventional MR imaging alone, we investigated whether contrast-enhanced 3D T2-FLAIR MR imaging at 3T helps to distinguish a Rathke cleft cyst from a cystic craniopharyngioma.

Materials And Methods: We evaluated pre- and postcontrast T1-weighted and 3D T2-FLAIR images of 17 patients with pathologically confirmed Rathke cleft cyst ( = 10) or cystic craniopharyngioma ( = 7). All underwent 3T MR imaging studies before surgery. Read More

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http://dx.doi.org/10.3174/ajnr.A6359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975334PMC
January 2020