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Antibiotics (Basel) 2022 May 31;11(6). Epub 2022 May 31.

Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.

  and are pathogenic free-living amoebae that infect the central nervous system with over 95% mortality rates. Although several compounds have shown promise in vitro but associated side effects and/or prolonged approval processes for clinical applications have led to limited success. To overcome this, drug repurposing of marketed compounds with known mechanism of action is considered a viable approach that has potential to expedite discovery and application of anti-amoebic compounds. Read More

J Neurosurg Case Lessons 2022 May 23;3(21):CASE21682. Epub 2022 May 23.

Department of Pediatric Neurosurgery, Santobono-Pausilipon Children's Hospital, Naples, Italy.

Background: Spinal arachnoid cysts (SAC) are rare, especially in children. Patients can be asymptomatic or present symptoms of spinal cord compression. In this latter case, surgery is indicated to relieve the compression. Read More

Neurocirugia (Astur : Engl Ed) 2022 Jul-Aug;33(4):190-194

Ege University, Faculty of Medicine, Department of Neurosurgery, İzmir, Turkey.

Primary diffuse leptomeningeal oligodendrogliomatosis is a rare fatal tumor of childhood. Symptoms usually occur when the tumor causes hydrocephalus. Brain magnetic resonance imaging (MRI) may be nearly normal in the early stages of the disease, while hydrocephalus and multiple leptomeningeal cysts with spongiform appearance may appear later on. Read More

Neurocirugia (Astur : Engl Ed) 2022 Jul-Aug;33(4):157-164

Department of Pediatrics, Universitary Hospital Miguel Servet, Zaragoza, Spain.

Introduction And Objective: Arachnoid cysts (ACs) are relatively frequent lesions related to different neurological symptoms, being mostly incidentally diagnosed. This study aims to clarify whether AC surgery in epileptic patients is useful in their treatment.

Material And Methods: The patients registered in the database of the Neuropediatrics Section from May 1990 to August 2019 are analyzed retrospectively. Read More

J Pak Med Assoc 2022 May;72(5):993-996

Aga Khan University Hospital, Karachi.

Colloid cysts are a group of CNS neoplasms that usually present with features of CSF flow obstruction. The treatment is by microsurgical, endoscopic or stereotactic techniques. Hydrocephalus usually resolves postoperatively, but in around 3-7% of cases symptoms persist and ultimately require CSF diversion. Read More

Am J Otolaryngol 2022 Jun 4:103519. Epub 2022 Jun 4.

Loyola University Chicago Stritch School of Medicine, Maywood, IL, United States of America; Department of Neurological Surgery, Loyola University Medical Center, Maywood, IL, United States of America; Department of Otolaryngology, Head and Neck Surgery, Loyola University Medical Center, Maywood, IL, United States of America. Electronic address:

Rathke's cleft cysts (RCCs) are sellar or suprasellar cystic lesions arising from the remnants of the embryological Rathke's pouch. When symptomatic, RCCs are usually treated surgically via marsupialization. Free mucosal graft (FMG) repair has shown promise in decreasing recurrence versus marsupialization alone. Read More

Neurologia (Engl Ed) 2022 Jun 26;37(5):325-333. Epub 2021 May 26.

Departamento de Pediatría, Radiología y Medicina Física, Facultad de Medicina de Zaragoza, Universidad de Zaragoza, Zaragoza, Spain.

Introduction: Neurofibromatosis type 1 (NF1) is a progressive multisystem disorder following an autosomal dominant inheritance pattern that presents with multiple neurological manifestations.

Methods: We reviewed medical histories of patients with NF1 followed up at our hospital's paediatric neurology department from May 1990 to 31 December 2018. We collected data on neurological symptoms. Read More

J Med Case Rep 2022 Jun 7;16(1):226. Epub 2022 Jun 7.

Department of Anesthesiology, University of North Carolina, N2198, CB #7010, Chapel Hill, NC, 27599-7010, USA.

Background: In this case report we describe an unusual case of a patient who underwent resection of a colloid cyst and then presented 6 weeks postoperatively with obstructive hydrocephalus. There appear to be no prior reports of such a delayed complication after colloid cyst resection.

Case Presentation: A 50-year-old Caucasian woman underwent resection of a colloid cyst with an uncomplicated perioperative course. Read More

Adv Sci (Weinh) 2022 Jun 6:e2201106. Epub 2022 Jun 6.

Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, Eindhoven, 5600 MB, The Netherlands.

Neuroepithelial (NE) organoids with dorsal-ventral patterning provide a useful three-dimensional (3D) in vitro model to interrogate neural tube formation during early development of the central nervous system. Understanding the fundamental processes behind the cellular self-organization in NE organoids holds the key to the engineering of organoids with higher, more in vivo-like complexity. However, little is known about the cellular regulation driving the NE development, especially in the presence of interfacial cues from the microenvironment. Read More

World Neurosurg 2022 May 31. Epub 2022 May 31.

Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China. Electronic address:

Objective: Papillary craniopharyngioma (PCP) was previously thought to occur only in adults. Sporadic pediatric PCP (PPCP) confirmed by detection of BRAF V600E mutation has been reported since 2018, but is often misdiagnosed before being diagnosed definitively. We aimed to evaluate PPCP characteristics and propose diagnostic criteria for prompt diagnosis, seeking to reduce patient morbidity and mortality and reduce costs linked to misdiagnosis. Read More

World Neurosurg 2022 Jun;162:210

College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Division of Neurosurgery, Department of Surgery, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia.

World Neurosurg 2022 Jun;162:208-209

Neurosurgical Clinic, AOUP "Paolo Giaccone," Post Graduate Residency Program in Neurologic Surgery, Department of Experimental Biomedicine and Clinical Neurosciences, School of Medicine, University of Palermo, Palermo, Italy.

PLoS Negl Trop Dis 2022 06 2;16(6):e0010449. Epub 2022 Jun 2.

Center for Global Health, Universidad Peruana Cayetano Heredia, Lima, Peru.

Background: Neurocysticercosis (NCC) is the infection of the human central nervous system (CNS) by Taenia solium larvae that cause significant neurological morbidity. Studies on NCC pathophysiology, host-parasite interactions or therapeutic agents are limited by the lack of suitable animal models. We have previously reported that carotid injection of activated T. Read More

Nihon Ronen Igakkai Zasshi 2022 ;59(2):219-224

Iwate Prefectural Ninohe Hospital Department of Neurosurgery.

The patient was an 83-year-old woman with a history of breast cancer, distal right radial edge bone fracture, and cervical spine symptoms who had been diagnosed with an arachnoid cyst 9 years previously. She was examined by a nearby doctor, because of an approximately 1-year history of reduced verbal output; she also begun experiencing difficulties with walking. However, she was diagnosed with aging, a history of cervical spondylosis, and the effects of past fractures. Read More

Brain Pathol 2022 May 30:e13083. Epub 2022 May 30.

Institute of Neuropathology, University Hospital Münster, Münster, Germany.

Hemangioblastomas (HBs) of the central nervous system are highly vascular neoplasms that occur sporadically or as a manifestation of von Hippel-Lindau (VHL) disease. Despite their benign nature, HBs are clinically heterogeneous and can be associated with significant morbidity due to mass effects of peritumoral cysts or tumor progression. Underlying molecular factors involved in HB tumor biology remain elusive. Read More

Int J Mol Sci 2022 May 16;23(10). Epub 2022 May 16.

Unitat de Fisiologia, Departament de Ciències Fisiològiques, Genes Disease and Therapy Program IDIBELL-Institute of Neurosciences, Universitat de Barcelona, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.

Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare type of vacuolating leukodystrophy (white matter disorder), which is mainly caused by defects in MLC1 or glial cell adhesion molecule (GlialCAM) proteins. In addition, autoantibodies to GlialCAM are involved in the pathology of multiple sclerosis. and genes encode for membrane proteins of unknown function, which has been linked to the regulation of different ion channels and transporters, such as the chloride channel VRAC (volume regulated anion channel), ClC-2 (chloride channel 2), and connexin 43 or the Na/K-ATPase pump. Read More

BMJ Case Rep 2022 05 27;15(5). Epub 2022 May 27.

Neurosurgery, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.

J Perinat Med 2022 May 25. Epub 2022 May 25.

Department of Ultrasound, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, P.R. China.

Objectives: To investigate the amino acid (AA)-related metabolic characteristics of amniotic fluid (AF) obtained by ultrasound-guided amniocentesis from fetuses with isolated choroid plexus cysts of the central nervous system.

Methods: Ultrasound-guided amniocentesis was performed on 17 fetuses with isolated choroid plexus cysts (ICPCs) and 17 normal fetuses. The AF samples from normal pregnancies were matched with the case samples in a 1:1 ratio based upon gestational age. Read More

JBJS Case Connect 2022 04 1;12(2). Epub 2022 Apr 1.

Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Case: We report 3 cases of thoracic myelopathy caused by vertebral osteophytes and coexisting intradural spinal arachnoid cyst (SAC), which was difficult to diagnose on preoperative magnetic resonance imaging. Intraoperative ultrasound sonography revealed spinal cord impingement because of osteophytes and a pulsating intradural SAC. Repeated pincer compression on the spinal cord seemed to be associated with their paraparetic symptoms. Read More

PLoS Comput Biol 2022 05 19;18(5):e1010118. Epub 2022 May 19.

Center for Global Health Tumbes, Universidad Peruana Cayetano Heredia, Lima, Peru.

Introduction: The Taenia solium tapeworm is responsible for cysticercosis, a neglected tropical disease presenting as larvae in the body of a host following taenia egg ingestion. Neurocysticercosis (NCC), the name of the disease when it affects the human central nervous system, is a major cause of epilepsy in developing countries, and can also cause intracranial hypertension, hydrocephalus and death. Simulation models can help identify the most cost-effective interventions before their implementation. Read More

BMJ Case Rep 2022 05 17;15(5). Epub 2022 May 17.

Medical Image Department, Neuroradiology Unit, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.

Am J Otolaryngol 2022 Jul-Aug;43(4):103487. Epub 2022 May 6.

The University of Mississippi Medical Center, Department of Otolaryngology, Head and Neck Surgery, 2500 North State St., Jackson, MS 39216, United States of America. Electronic address:

Objective: The purpose of this report is to describe a case of bilateral cochlear implantation (CI) in a pediatric patient with Chudley-McCullough Syndrome (CMS). By reviewing the literature, we hope to describe common clinical presentations to aid in early diagnosis and management of pediatric patients with CMS.

Methods: Case report with literature review. Read More

Neurol India 2022 Mar-Apr;70(2):515-519

Department of Neurosurgery and Gamma-Knife, All India Institute of Medical Sciences, New Delhi, India.

Background And Introduction: The interhemispheric transcallosal approach provides an elegant pathway to access the lesions of the third ventricle. However, every step of this approach is fraught with hazards which must be negotiated delicately. A comprehensive knowledge of surgical anatomy coupled with technical skill is necessary for optimum surgical results. Read More

Ann Endocrinol (Paris) 2022 Apr 30. Epub 2022 Apr 30.

Department of Endocrinology of the CHU of Reims, Hôpital Robert Debré, rue du Général-Koenig, 51100 Reims, France; CRESTIC EA 3804, Reims Champagne-Ardenne University, Moulin de la Housse, 51687, Reims, France.

Front Vet Sci 2022 15;9:871023. Epub 2022 Apr 15.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, United States.

Congenital epidermoid cysts are slow-growing, mass lesions caused by the abnormal inclusion of neuroectodermal tissue within the developing central nervous system. Subtotal excision of epidermoid cysts increases the risk of early recurrence of clinical signs. A 4-year-old female spayed boxer was presented with a 4-month history of ambulatory paraparesis and proprioceptive ataxia. Read More

J Clin Neurosci 2022 Jun 28;100:204-211. Epub 2022 Apr 28.

Department of Pathology, Tangdu Hospital, Air Force Medical University, Xi'an, PR China. Electronic address:

Collision tumors are extremely rare in the sellar region, and their features have not been fully characterized. Here, we report our single-center experience in the diagnosis and management of these tumors, focusing primarily on their clinicopathological features. We first performed a retrospective study of pathological reports from patients who had undergone surgery for pituitary adenoma (PA) or craniopharyngioma (CP) at our hospital. Read More

Schizophr Res 2022 Jun 26;244:1-7. Epub 2022 Apr 26.

Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia; North Western Mental Health, Western Hospital Sunshine, St. Albans, Victoria, Australia.

Background: Pineal volume reductions have been reported in schizophrenia and clinical high-risk states for the development of psychosis, supporting the role of melatonin dysregulation in the pathophysiology of psychosis. However, it remains unclear whether pineal volume is associated with the later onset of psychosis in individuals at clinical high-risk (CHR) of psychosis or if pineal atrophy is specific to schizophrenia among different psychotic disorders.

Methods: This magnetic resonance imaging study examined the volume of and cyst prevalence in the pineal gland in 135 individuals at CHR of psychosis [52 (38. Read More

Bol Med Hosp Infant Mex 2022 ;79(2):129-134

Departamento de Genética, Escuela de Medicina, Universidad Cuauhtémoc. San Luis Potosí, San Luis Potosí, México.

Background: Megalencephalic leukoencephalopathy with subcortical cysts is a rare type of leukodystrophy associated with mutations in the MLC1 and GlialCAM genes. The classic form is characterized by macrocephaly, early or delayed normal neurodevelopment followed by a period of slow motor skill loss, with cerebellar ataxia and spasticity; some patients develop movement disorders and seizures. Magnetic resonance imaging shows widespread diffuse white matter involvement with edema and subcortical cysts. Read More

World Neurosurg 2022 Apr 20;164:8-24. Epub 2022 Apr 20.

Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA; Carilion Clinic Neurosurgery, Roanoke, Virginia, USA. Electronic address:

Background: Neurenteric cysts (NC) are uncommon congenital lesions with histopathologic properties derived from the gastrointestinal or respiratory tract. They are typically located in the intradural extramedullary compartment but rarely seen in the supratentorial region. The occurrence of supratentorial NCs (S-NC) presents an interesting quandary regarding their embryopathogenesis. Read More

Tomography 2022 04 14;8(2):1141-1147. Epub 2022 Apr 14.

Department of Neuroradiology, S. Andrea Hospital, University Sapienza, 5, 00185 Rome, Italy.

Asterion is an uncommon site for lesions, especially dermoid cysts. We report a case series of three asterional intracranial dermoid cysts, which, to the best of our knowledge, have never been described before. Patients presented with non-specific symptoms and underwent surgical excision of the lesions. Read More