478 results match your criteria Rathke Cleft Cyst


Endoscopic endonasal resection of symptomatic Rathke cleft cysts: clinical outcomes and prognosis.

Neurosurg Rev 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

The aim of this study is to investigate the clinical presentation and outcomes associated with endoscopic endonasal resection of Rathke cleft cysts (RCCs). The authors retrospectively studied a series of 13 patients who were diagnosed with RCCs after endoscopic endonasal resection at the Second Xiangya Hospital between June 2016 and December 2017. All 13 patients (8 women) underwent a purely endoscopic endonasal approach (EEA) for fenestration and aspiration of RCCs with excision of the cystic wall. Read More

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December 2018
1 Read

Secondary pituitary abscess following transsphenoidal surgery with recurrent meningitis: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13458

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Rationale: The transsphenoidal surgical (TS) approach to sellar masses is the preferred surgical route in most cases. Secondary pituitary abscess (PA) following TS is an extremely rare but serious postoperative complication with potentially high disability and mortality.

Patient Concerns: We describe an uncommon case of secondary PA in a 42-year-old woman, who underwent uncomplicated transsphenoidal procedures without cerebrospinal fluid leak, to treat primary Rathke cleft cyst. Read More

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November 2018
1 Read

Clipping of a superior hypophyseal artery aneurysm during endoscopic transnasal removal of a Rathke cleft cyst: a case report.

Acta Neurochir (Wien) 2018 Nov 26. Epub 2018 Nov 26.

Department of Neurosurgery, Clinical Neuroscience Center, University Hospital of Zürich, University of Zürich, Frauenklinikstrasse 10, 8006, Zürich, Switzerland.

The concomitant presence of an aneurysm in contact with a sellar lesion usually contraindicates a transsphenoidal approach (TSS). Clipping of an intracranial aneurysm is however possible in highly selected cases also through an endoscopic TSS approach, as long as the basic principles of cerebrovascular surgery are respected. We report thus on a case of a patient harboring a Rathke cleft cyst (RCC) and an aneurysm of the carotid artery (ICA) in close contact with the RCC. Read More

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November 2018

Xanthomatous hypophysitis causing hypogonadotropic hypogonadism resulting in delayed presentation of slipped capital femoral epiphysis.

Br J Neurosurg 2018 Nov 19:1-4. Epub 2018 Nov 19.

a Department of Neurosurgery , NHS Tayside , Dundee , United Kingdom.

An 18-year-old man who underwent bilateral pinning of his hip joints after a left unstable Slipped Capital Femoral Epiphysis (right pinned prophylactically) was noted to have delayed secondary sexual characteristics and post-operative diabetes insipidus. The patient also described a history of fatigue, headache and polydipsia for the past 4 years. Endocrine investigations revealed reduced androgen levels, hypocortisolism, a borderline normal Serum ACE and secondary hypothyroidism. Read More

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November 2018
4 Reads

Benefit of Intracystic Bleomycin for Symptomatic Recurrent Rathke Cleft Cyst.

Oper Neurosurg (Hagerstown) 2018 Nov 16. Epub 2018 Nov 16.

School of Medicine, University of Colorado, Aurora, Colorado.

Background: Management of recurrent Rathke cleft cysts (RCC) is problematic. The mainstay of treatment has been reoperation with cyst drainage. Radical cyst resection, although effective, results in a high incidence of diabetes insipidus. Read More

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November 2018
2 Reads

Dosimetry estimate and initial clinical experience with Y-PSMA-617.

J Nucl Med 2018 Nov 2. Epub 2018 Nov 2.

University Hospital of Heidelberg, Germany.

Due to different physical properties, the beta-emitters Lu and Y offer specific radiation-biological advantages in dedicated clinical situations, respectively. Our objective was to introduce Y-PSMA-617 to clinical application, providing additional avenues for personalized medicine. Here we present our dosimetry-estimate for Y-PSMA-617, report initial clinical experiences and discuss the advantages and drawbacks of varying the beta-emitter in prostate-specific membrane antigen (PSMA) targeting radioligand therapy (RLT). Read More

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November 2018
8 Reads

Giant Sellar Xanthogranuloma after Surgical Treatment of Symptomatic Rathke's Cleft Cyst.

Brain Tumor Res Treat 2018 Oct;6(2):82-85

Department of Pathology, Kosin University Gospel Hospital, Busan, Korea.

Extremely massive sellar xanthogranuloma (XG) are rare, and the surgical outcome and prognosis are not well known. XG remain unknown whether they are derived from Rathke's cleft cysts (RCCs) or craniopharyngiomas (CPs) following extensive inflammation and metaplasia, to the point that no epithelium is readily identifiable. These lesions usually tend to occur in younger patients (mean 28. Read More

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October 2018
2 Reads

Xanthogranuloma of the sellar region: A rare tumor. Case illustration and literature review.

J Clin Neurosci 2018 Oct 14. Epub 2018 Oct 14.

Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy.

Xanthogranulomas are rare intracranial lesions with controversial etiology. The sellar location is exceedingly rare. Here we report a clinical case and a review of the English-language literature of histologically confirmed xanthogranulomas in order to furnish useful tools in diagnosis and management of this unusual disease. Read More

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October 2018
2 Reads

Single center study of 53 consecutive patients with pituitary stalk lesions.

Pituitary 2018 Dec;21(6):605-614

Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Dr Subotica 13, Belgrade, 11000, Serbia.

Background: The etiological spectrum of pituitary stalk lesions (PSL) is wide and yet specific compared to the other diseases of the sellar and suprasellar region. Because of the pituitary stalk's (PS) critical location and role, biopsies of these lesions are rarely performed, and their underlying pathology is often a conundrum for clinicians. A pituitary MRI in association with a clinical context can facilitate their diagnosis. Read More

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December 2018
3 Reads

Nejire/dCBP-mediated histone H3 acetylation during spermatogenesis is essential for male fertility in Drosophila melanogaster.

PLoS One 2018 7;13(9):e0203622. Epub 2018 Sep 7.

Philipps University of Marburg, Department of Biology, Developmental Biology, Marburg, Germany.

Spermatogenesis in many species including Drosophila melanogaster is accompanied by major reorganisation of chromatin in post-meiotic stages, involving a nearly genome-wide displacement of histones by protamines, Mst77F and Protamine-like 99C. A proposed prerequisite for the histone-to-protamine transition is massive histone H4 hyper-acetylation prior to the switch. Here, we investigated the pattern of histone H3 lysine acetylation and general lysine crotonylation in D. Read More

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September 2018
7 Reads

Initial clinical experience performing sialendoscopy for salivary gland protection in patients undergoing Ac-PSMA-617 RLT.

Eur J Nucl Med Mol Imaging 2019 Jan 27;46(1):139-147. Epub 2018 Aug 27.

Department of Otorhinolaryngology, Head and Neck Surgery (ORL-HNS), Heidelberg University Hospital, Heidelberg, Germany.

Purpose: The main side effect of prostate-specific membrane antigen targeting alpha therapy (PSMA TAT) is dry mouth syndrome. Inflammation of the salivary glands and consequent reduced salivary function have been reported in patients after radioiodine therapy. The beneficial effects of sialendoscopy on radiation-induced inflammation in tissue are well known. Read More

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January 2019
16 Reads

Diabetes Insipidus Presenting with Oligohydramnios and Polyuria During Pregnancy.

J Nippon Med Sch 2018 ;85(3):191-193

Department of Internal Medicine, Chonnam National University Medical School.

We report a case of subclinical central diabetes insipidus (DI), due to Rathke's cleft cysts, that was initially misdiagnosed as transient DI of pregnancy because it presented in the third trimester of pregnancy. A 37-year-old primigravida visited the Department of Obstetrics in the 30th week of gestation due to polyuria. She was admitted due to oligohydramnios; the amniotic fluid index was 3. Read More

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October 2018
14 Reads

Impact of sialendoscopy on improving health related quality of life in patients suffering from radioiodineinduced xerostomia.

Nuklearmedizin 2018 Aug 20;57(4):160-167. Epub 2018 Aug 20.

Introduction: Xerostomia following radioiodine therapy (RIT) in patients suffering from differentiated thyroid cancer is a common side effect in 2 % to 67 % of patients treated with radioiodine (I-131). In order to evaluate the impact of sialendoscopy on health related quality of life (HRQOL) in patients suffering from therapy induced sialadenitis and xerostomia, we analyzed findings from two dedicated questionnaires (Xerostomy Questionnaire XQ and Xerostomy Inventory XI) in patients before and three months after sialendoscopy.

Procedures: In total, 12 patients suffering from differentiated thyroid carcinoma (10 women and 2 men) were evaluated. Read More

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Abdominal Fat Graft for Sellar Reconstruction: Retrospective Outcomes Review and Technical Note.

Oper Neurosurg (Hagerstown) 2018 Aug 16. Epub 2018 Aug 16.

Department of Neurological Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: The transsphenoidal approach is the standard of care for the treatment of pituitary adenomas and is increasingly employed for many anterior skull base tumors. Persistent postoperative cerebrospinal fluid (CSF) leaks can result in significant complications.

Objective: To analyze our series of patients undergoing abdominal fat graft repair of the sellar floor defect following transsphenoidal surgery, describe and investigate our current, routine technique, and review contemporary and past methods of skull base repair. Read More

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The Coexistence of Growth Hormone-Producing Pituitary Adenoma and Rathke Cleft Cyst: How Can We Diagnosis Preoperation?

J Craniofac Surg 2018 Oct;29(7):1887-1889

Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University.

Pituitary adenoma (PA) rarely coexists with Rathke's cleft cyst (RCC). Previously, only 13 cases of patients with growth hormone (GH)-producing PA and concomitant RCC have been reported. Here, the authors report a 54-year-old female patient with a GH-secreting PA coexisting with an RCC. Read More

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October 2018
14 Reads

Symptomatic Rathke cleft cyst in paediatric patients - clinical presentations, surgical treatment and postoperative outcomes - an analysis of 38 cases.

J Pediatr Endocrinol Metab 2018 Aug;31(8):903-910

Department of Endocrinology and Diabetology, Children's Memorial Health Institute, Warsaw, Poland.

Background: Rathke cleft cysts (RCC) are benign, epithelium-lined intrasellar and/or suprasellar cysts believed to originate from the remnants of the Rathke pouch. The aim of this study was to analyse the symptoms and surgical outcome of patients with the diagnosis of RCC verified in a histopathological examination of the postoperative material.

Methods: The study is a retrospective analysis of 38 cases of children who underwent a neurosurgical treatment due to RCC at the Children's Memorial Health Institute in Warsaw, Poland, between 1994 and 2015. Read More

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August 2018
5 Reads

Ga-PSMA-11 PET/CT in Primary and Recurrent Prostate Carcinoma: Implications for Radiotherapeutic Management in 121 Patients.

J Nucl Med 2018 Jul 5. Epub 2018 Jul 5.

University Hospital Heidelberg, Germany.

The present study analyzed the impact of Gallium-68 (Ga)-labeled prostate-specific membrane antigen-HBED-CC (Ga-PSMA-11) positron-emission tomography (PET)/computed tomography (CT) on radiotherapeutic management in a large cohort of men with primary or recurrent disease. This study investigated 121 men with carcinoma of the prostate who underwent Ga-PSMA-11 PET/CT as well as conventional imaging. 50 patients were treatment naive, 11 had persistent prostate-specific antigen (PSA) soon after surgery and 60 presented with recurrent PSA following definitive therapy. Read More

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July 2018
10 Reads

Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner.

Nat Commun 2018 05 29;9(1):2112. Epub 2018 May 29.

Institute for Molecular Biology and Tumour Research, University of Marburg, 35043, Marburg, Germany.

ATP-dependent chromatin remodellers are mutated in more than 20% of human cancers. The consequences of these mutations on enzyme function are poorly understood. Here, we characterise the effects of CHD4 mutations identified in endometrial carcinoma on the remodelling properties of dMi-2, the highly conserved Drosophila homologue of CHD4. Read More

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May 2018
6 Reads

Premature Expression of FOXO1 in Developing Mouse Pituitary Results in Anterior Lobe Hypoplasia.

Endocrinology 2018 Aug;159(8):2891-2904

Department of Physiology, Southern Illinois University, Carbondale, Illinois.

The process by which the somatotrope lineage emerges in the developing pituitary is regulated by the activity of specific signaling and transcription factors expressed during development. We set out to understand the contribution of FOXO1 to that process by using a mouse model in which FOXO1 is prematurely expressed in the pituitary primordium. Expression of FOXO1 in the oral ectoderm as early as embryonic day (e)9. Read More

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Natural history of Rathke's cleft cysts: A retrospective analysis of a two centres experience.

Clin Endocrinol (Oxf) 2018 May 21. Epub 2018 May 21.

Department of Neurological Surgery, Stanford University Hospital, Stanford, CA, USA.

Objective: Rathke's cleft cyst (RCC) is a common sellar lesion which may cause visual impairment, hypopituitarism and headaches from mass effect. The natural history of these lesions is currently unclear. We investigated the natural history of RCCs and compared surgically treated patients with those treated conservatively. Read More

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May 2018
1 Read

[Rathke cysts, craniopharyngioma, and colloid cysts : What are the differences between these pathologies?]

Authors:
R Eymann M Kiefer

Radiologe 2018 Jul;58(7):646-652

Universität des Saarlandes, Homburg/Saar, Deutschland.

Clinical Issue: Headache is the most common symptom of colloid cysts, Rathke cysts, and craniopharyngioma due to their location in the midline, being extra-axial and typically presenting in the parasellar region.

Therapeutic Problems: Although these tumors are generally considered benign, each has its typical characteristics defined by its location and histology. These individual characteristics define whether surgery is necessary at all and if so, the preferred surgical approach and resection's totality. Read More

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Vapor Liquid Equilibria of Binary Mixtures of 1-Butyl-3-methylimidazolium Triflate (CmimTfO) and Molecular Solvents: n-Alkyl Alcohols and Water.

J Phys Chem B 2018 Jun 25;122(22):6017-6032. Epub 2018 May 25.

Universität Bremen , FB4, Technische Thermodynamik , Badgasteiner Strasse 1 , 28359 Bremen , Germany.

Isobaric vapor liquid equilibria (VLE) of binary mixtures of the ionic liquid (IL) 1-butyl-3-methylimidazolium trifluoromethanesulfonate (CmimTfO) with either water or short chained n-alkyl alcohols (methanol, ethanol, propan-1-ol, and butan-1-ol) are described in this study. Two different microebulliometers and a classical VLE apparatus were compared and the VLEs were determined in the composition range 0.4 ≤ x(solvent) ≤ 1 at three different pressure levels ( p = 500 mbar, 700 mbar, and 1000 mbar). Read More

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June 2018
1 Read

Rathke's Cleft Cyst or Pituitary Apoplexy: A Case Report and Literature Review.

Open Access Maced J Med Sci 2018 Mar 13;6(3):544-547. Epub 2018 Mar 13.

Diagnostic Center, Clinic of Radiology, University Clinical Center of Kosovo, Prishtina, Kosovo.

Background: During the examination of the sellar region by magnetic resonance imaging, hyperintensity in T1 weighted is a common finding. This signal intensity has different sources, and its significance depends on the clinical context. Pathologic variations in T1 signal hyperintensity may be related to clotting of blood (pituitary apoplexy) or the presence of a high concentration of protein (Rathke cleft cyst). Read More

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March 2018
6 Reads

Combined Frontotemporal Transbasal Approach for the Resection of a Giant Rathke's Cleft Cyst: Operative Video and Technical Nuances.

Authors:
James K Liu

J Neurol Surg B Skull Base 2018 Apr 26;79(Suppl 3):S276-S277. Epub 2018 Feb 26.

Department of Neurological Surgery, Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers University, New Jersey Medical School, Newark, New Jersey, United States.

We present a case of a giant Rathke's cleft cyst with significant superior extension into the third and right lateral ventricles and lateral extension into the left Sylvian fissure and over the anterior clinoid process. An extended modification of the frontotemporal approach was performed using a combined frontotemporal transbasal approach. This allowed wide exposure to both transsylvian and subfrontal corridors to the retrochiasmatic space. Read More

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April 2018
4 Reads

Lymphocytic Hypophysitis Secondary to Ruptured Rathke Cleft Cyst: Case Report and Literature Review.

World Neurosurg 2018 Jun 20;114:172-177. Epub 2018 Mar 20.

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Background: Lymphocytic hypophysitis is a rare inflammatory lesion in the sellar region. Lymphocytic hypophysitis secondary to ruptured Rathke cleft cyst (RCC) is even more rarely seen. Clinical characteristics, treatment strategies, and prognosis remain elusive. Read More

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Arsenic sorption on zero-valent iron-biochar complexes.

Water Res 2018 06 9;137:153-163. Epub 2018 Mar 9.

Department of Agronomy, Iowa State University, Ames, IA 50011, USA.

Arsenic (As) is toxic to human and is often found in drinking water in India and Bangladesh, due to the natural abundance of arsenides ores. Different removal procedures such as precipitation, sorption, ion exchange and membrane separation have been employed for removal of As from contaminated drinking water (CDW), however, there is a critical need for low-cost economically viable biochar modification methods which can enhance As sorption. Here we studied the effectiveness of zero-valent iron (ZVI)-biochar complexes produced by high temperature pyrolysis of biomass and magnetite for removing As from CDW. Read More

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June 2018
1 Read

Incidence of epistaxis after endoscopic pituitary surgery: Proposed treatment algorithm.

Ear Nose Throat J 2018 Mar;97(3):E44-E48

Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0528, Cincinnati OH, 45267-0528, USA.

Endoscopic transsphenoidal surgery for pituitary tumors is an increasingly common practice. Little has been reported on the incidence and treatment of postoperative epistaxis in this population. The aim of this study was to analyze the incidence of postoperative epistaxis and formulate a treatment algorithm based on our experience. Read More

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Rathke's cleft cyst associated with pituitary granulomatosis with polyangiitis: An unusual combination of hypothalamus-pituitary region pathologies.

Radiol Case Rep 2018 Feb 31;13(1):233-236. Epub 2017 Oct 31.

Department of Neurosurgery, Fondazione IRCCS "Ca' Granda" Ospedale Maggiore Policlinico, Milan, Italy.

The authors present an unusual case of a patient suffering from visual deficit due to pituitary granulomatosis with polyangiitis (GPA) associated with Rathke's cleft cyst (RCC). The patient was referred to our Neurosurgery Department presenting right eye amaurosis, third cranial nerve palsy, and left temporal hemianopsia. Magnetic resonance imaging documented a sellar or suprasellar lesion with solid and cystic components. Read More

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February 2018
15 Reads

Rathke's Cleft Cyst as Origin of a Pediatric Papillary Craniopharyngioma.

Front Genet 2018 22;9:49. Epub 2018 Feb 22.

Institute of Neuropathology, University Hospital Erlangen Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.

A 6-year old patient presented with an intra and suprasellar cystic lesion accompanied with impairment of the hypothalamic-pituitary axis and partial hypopituitarism. The most likely cause of sellar lesions in this age group are adamantinomatous craniopharyngioma (adaCP) or Rathke´s cleft cysts (RCCs). AdaCP are characterized by mutations accompanied with aberrant nuclear beta-catenin expression. Read More

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February 2018

Persistent craniopharyngeal canal, bilateral microphthalmia with colobomatous cysts, ectopic adenohypophysis with Rathke cleft cyst, and ectopic neurohypophysis: case report and review of the literature.

Childs Nerv Syst 2018 Jul 14;34(7):1407-1410. Epub 2018 Feb 14.

Department of Radiology, Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital, University of Health Sciences, Şehit Ömer Halisdemir Cad. Kurtdereli Sok, 06110, Ankara, Altındağ, Turkey.

Introduction: Persistent craniopharyngeal canal (PCC) is a rare anomaly of the base of the skull. PCC is defined as a well-corticated osseous canal, extending from the roof of the nasopharynx to the base of the sella over the course of the sphenoid corpus. We reported a PCC case with unique associations. Read More

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July 2018
5 Reads

Clinical Features and Treatment of Secondary Pituitary Abscess After Transsphenoidal Surgery: A Retrospective Study of 23 Cases.

World Neurosurg 2018 May 6;113:e138-e145. Epub 2018 Feb 6.

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Objective: Pituitary abscess (PA) is a rare but serious intrasellar disorder with potentially high disability and mortality. Secondary PA after transsphenoidal surgery (TS) is extremely rare, and only a few case reports have been identified in the literature. This study explored the salient clinical manifestations and etiologies to determine appropriate treatment. Read More

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May 2018
4 Reads

One-piece Orbitozygomatic Craniotomy for Resection of Rathke's Cleft Cyst: Operative Video.

J Neurol Surg B Skull Base 2018 Feb 11;79(2):S211-S212. Epub 2018 Jan 11.

Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States.

 The video stars orbitozygomatic resection of Rathke's cleft cyst with suprasellar extension in a 37-year-old male patient presenting with severe headaches and bitemporal hemianopia. Clinical and radiological characteristics along with surgical technique (positioning, bony opening, surgical dissection and debulking, closure), histopathology, and postoperative course are described.  Preoperative MRI demonstrated a noncontrast-enhancing cystic lesion in the sella with suprasellar extension causing compression of both optic nerves. Read More

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February 2018
1 Read

The diagnostic value of preoperative inflammatory markers in craniopharyngioma: a multicenter cohort study.

J Neurooncol 2018 May 31;138(1):113-122. Epub 2018 Jan 31.

Department of Neurosurgery, XinHua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200092, China.

To compare the different levels of preoperative inflammatory markers in peripheral blood samples between craniopharyngioma (CP) and other sellar region tumors so as to explore their differential diagnostic value. The level of white blood cell (WBC), neutrophil, lymphocyte, monocyte, platelet, albumin, neutrophil lymphocyte ratio (NLR), derived NLR (dNLR), platelet lymphocyte ratio (PLR), monocyte lymphocyte ratio (MLR) and prognostic nutritional index (PNI) were compared between the CP and other sellar region tumors. A receiver operating characteristics (ROC) curve analysis was performed to evaluate the diagnostic significance of the peripheral blood inflammatory markers and their paired combinations for CP including its pathological types. Read More

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May 2018
1 Read

Factors Affecting Visual Field Outcome Post-Surgery in Sellar Region Tumors: Retrospective Study.

Malays J Med Sci 2017 Dec 29;24(6):58-67. Epub 2017 Dec 29.

Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

Background: Despite the broad category of differentials for sellar region, most of them present with similar clinical signs and symptoms. Headache and visual disturbance are among the frequently seen as presenting symptom. Visual field (VF) assessment is one of the crucial component of neuroophtalmologic assessment and mean deviation (MD) value from automated perimetry allows quantification of the visual field defect. Read More

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December 2017
3 Reads

Intraindividual Comparison of Tc-Methylene Diphosphonate and Prostate-Specific Membrane Antigen Ligand Tc-MIP-1427 in Patients with Osseous Metastasized Prostate Cancer.

J Nucl Med 2018 Sep 25;59(9):1373-1379. Epub 2018 Jan 25.

Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.

The objective of this study was to evaluate the rate of detection of bone metastases obtained with the prostate-specific membrane antigen (PSMA)-targeting tracer Tc-MIP-1427, as opposed to conventional bone scanning with Tc-methylene diphosphonate (Tc-MDP), in a collective of patients with known advanced-stage osseous metastasized prostate cancer. Twenty-one patients with known metastatic disease were staged with both conventional bone scanning and PSMA ligand scintigraphy within a time frame of less than 10 d. Imaging included planar whole-body scanning and SPECT or SPECT/CT with 2 bed positions 3 h after injection of either 500-750 MBq of Tc-MIP-1427 or 600-750 MBq of Tc-MDP. Read More

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September 2018
8 Reads

Targeted α-Therapy of Metastatic Castration-Resistant Prostate Cancer with Ac-PSMA-617: Swimmer-Plot Analysis Suggests Efficacy Regarding Duration of Tumor Control.

J Nucl Med 2018 May 11;59(5):795-802. Epub 2018 Jan 11.

Directorate for Nuclear Safety and Security, Joint Research Centre, European Commission, Karlsruhe, Germany.

The aim of this evaluation was to identify the first indicators of efficacy for Ac-labeled prostate-specific membrane antigen (PSMA)-617 therapy in a retrospectively analyzed group of patients. Forty patients with metastatic castration-resistant prostate cancer were selected for treatment with three 100 kBq/kg cycles of Ac-PSMA-617 at 2-mo intervals. Prostate-specific antigen (PSA) and blood cell count were measured every 4 wk. Read More

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May 2018
14 Reads

Headache Resolution After Rathke Cleft Cyst Resection: A Meta-Analysis.

World Neurosurg 2018 Mar 5;111:e764-e772. Epub 2018 Jan 5.

Massachusetts College of Pharmacy and Health Sciences University, Boston, Massachusetts, USA. Electronic address:

Objective: Rathke cleft cysts (RCC) are benign lesions of the sella that often present with headache. It is not currently well established whether surgical resection of RCC results in resolution of headache. We conducted a meta-analysis to examine the effect of RCC resection on headache resolution. Read More

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March 2018
10 Reads
2.420 Impact Factor

The origins of the circumventricular organs.

Authors:
Clemens Kiecker

J Anat 2018 Apr 27;232(4):540-553. Epub 2017 Dec 27.

Department of Developmental Neurobiology, King's College London, London, UK.

The circumventricular organs (CVOs) are specialised neuroepithelial structures found in the midline of the brain, grouped around the third and fourth ventricles. They mediate the communication between the brain and the periphery by performing sensory and secretory roles, facilitated by increased vascularisation and the absence of a blood-brain barrier. Surprisingly little is known about the origins of the CVOs (both developmental and evolutionary), but their functional and organisational similarities raise the question of the extent of their relationship. Read More

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April 2018
5 Reads

Presentation and outcomes in surgically and conservatively managed pediatric Rathke cleft cysts.

J Neurosurg Pediatr 2018 Mar 22;21(3):308-314. Epub 2017 Dec 22.

Departments of 1 Neurosurgery and.

OBJECTIVE Rathke cleft cysts (RCCs) are sellar lesions that are commonly encountered in adults but infrequently diagnosed in the pediatric population. As a result, the optimal management of pediatric RCCs remains a subject of controversy. Only 2 prior surgical series have been published on pediatric RCCs and no study has compared the presentation and outcomes of surgically versus conservatively managed cases. Read More

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March 2018
8 Reads

Integration of CT urography improves diagnostic confidence of Ga-PSMA-11 PET/CT in prostate cancer patients.

Cancer Imaging 2017 Dec 20;17(1):30. Epub 2017 Dec 20.

Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.

Background: To prove the feasibility of integrating CT urography (CTU) into Ga-PSMA-11 PET/CT and to analyze the impact of CTU on assigning focal tracer accumulation in the ureteric space to either ureteric excretion or metastatic disease concerning topographic attribution and diagnostic confidence.

Methods: Ten prostate cancer patients who underwent Ga-PSMA-11 PET/CT including CTU because of biochemical relapse or known metastatic disease were retrospectively analyzed. CTU consisted of an excretory phase 10 min after injection of 80 mL iodinated contrast material. Read More

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December 2017
23 Reads

Revision of Brada Stimpson, 1853, and Bradabyssa Hartman, 1967 (Annelida, Flabelligeridae).

Zootaxa 2017 Nov 3;4343(1):1-98. Epub 2017 Nov 3.

Estructura y Función del Bentos, Depto. Sistemática y Ecología Acuática, El Colegio de la Frontera Sur, Chetumal, Quintana Roo, 77000 MEXICO..

Among flabelligerid genera Brada Stimpson, 1853 includes several species whose bodies are fusiform or club-shaped, often with a reduced number of chaetigers, and their members are found in temperate and polar waters. In contrast, Bradabyssa Hartman, 1967 is regarded as a monotypic genus with a single Antarctic species with a cylindrical body and a variable number of chaetigers. After examination of all type and non-type material available of both genera, two distinct body patterns were distinguished: one includes the type species for Brada, B. Read More

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November 2017
15 Reads

Delayed Occurrence of Diabetes Insipidus After Transsphenoidal Surgery with Radiologic Evaluation of the Pituitary Stalk on Magnetic Resonance Imaging.

World Neurosurg 2018 Feb 9;110:e1072-e1077. Epub 2017 Dec 9.

Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

Background: Diabetes insipidus (DI) is a major complication of transsphenoidal surgery (TSS). DI usually occurs within a couple of days after TSS. Delayed occurrence of postoperative DI is rarely observed and its developing mechanisms remain unknown. Read More

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February 2018
6 Reads

Clinical significance of thickened sphenoid sinus mucosa in Rathke's cleft cyst.

Surg Neurol Int 2017 1;8:263. Epub 2017 Nov 1.

Department of Neurosurgery, St. Marianna University School of Medicine, Kawasaki, Japan.

Background: To determine the clinical significance of thickening of the sphenoid sinus mucosa (TSSM) in Rathke's cleft cyst (RCC).

Methods: We retrospectively reviewed patients with pituitary lesions. A total of 99 patients, who underwent surgery of pituitary lesions between 2008 and 2015, were analyzed to evaluate the clinical significance of TSSM using magnetic resonance imaging. Read More

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November 2017
5 Reads

Central Diabetes Insipidus Linked to Rathke's Cleft Cyst, Polyuria in a 17-year-old Girl.

Electrolyte Blood Press 2017 Sep 30;15(1):23-25. Epub 2017 Sep 30.

Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

A 17-year-old girl presented with polyuria (7 L/day) and polydipsia for one year. Initial urine osmolality was 113mOsm/kg HO. Following 6 h of fluid restriction, serum plasma osmolality reached 300mOsm/kg HO, whereas urine osmolality was 108mOsm/kg HO. Read More

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September 2017
6 Reads

Targeted alpha therapy of mCRPC: Dosimetry estimate of Bismuth-PSMA-617.

Eur J Nucl Med Mol Imaging 2018 Jan 11;45(1):31-37. Epub 2017 Sep 11.

Department of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.

Purpose: PSMA-617 is a small molecule targeting the prostate-specific membrane antigen (PSMA). In this work, we estimate the radiation dosimetry for this ligand labeled with the alpha-emitter Bi.

Methods: Three patients with metastatic prostate cancer underwent PET scans 0. Read More

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January 2018
37 Reads

New Technique for Chiasmapexy Using Iliac Crest Bone Graft: 2 Cases of Visual Impairment Caused by Empty Sella Syndrome.

World Neurosurg 2017 Nov 24;107:1051.e19-1051.e25. Epub 2017 Aug 24.

Department of Neurosurgery, Nippon Medical School, Tokyo, Japan.

Background: Chiasmapexy is used to treat empty sella syndrome, and various materials are used for the elevation of the optic chiasm. However, the use of artificial substances may have the risk of graft infection, and fat and muscle may be absorbed over the long term after surgery. In addition, bone and cartilage may be unavailable in adequate amounts. Read More

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November 2017
9 Reads

High-resolution melting and immunohistochemical analysis efficiently detects mutually exclusive genetic alterations of adamantinomatous and papillary craniopharyngiomas.

Neuropathology 2018 Feb 25;38(1):3-10. Epub 2017 Aug 25.

Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Craniopharyngioma consists of adamantinomatous and papillary subtypes. Recent genetic analysis has demonstrated that the two subtypes are different, not only in clinicopathological features, but also in molecular oncogenesis. Papillary craniopharyngioma (pCP) is characterized by a BRAF mutation, the V600E (Val 600 Glu) mutation. Read More

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February 2018
4 Reads