605,378 results match your criteria Rapid Communications in Mass Spectrometry[Journal]


Incidence of Thyroid Cancer among Patients with Thyroid Nodules

Authors:
A Gilmartin M Ryan

Ir Med J 2018 09 10;111(8):802. Epub 2018 Sep 10.

Barrington’s Hospital, Limerick.

Aim To evaluate thyroid nodules and to determine the incidence of thyroid cancer. Methods This retrospective cohort study collected data from ten patients who presented with thyroid nodules to Barrington’s Hospital Limerick. Ultrasound/FNA results of thyroid nodules were used to measure the incidence of thyroid cancer. Read More

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September 2018
3 Reads

Nanotoxicity Assessment Using Embryonic Zebrafish.

Methods Mol Biol 2019 ;1894:331-343

Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, USA.

The emergence of nanomaterials in industrial processing and consumer products has generated an increased presence of nano-enabled products in the environment and now pose an increased risk of exposure to living organisms. However, assessing the risks of nanomaterials is a challenging task because of a large variety and great variability in their properties. Here, we describe a methodology for assessing toxicity and evaluate potential risks posed by nanomaterials using zebrafish embryos as a model organism. Read More

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January 2019

Utilizing Atlas-Based Modeling to Predict Knee Joint Cartilage Degeneration: Data from the Osteoarthritis Initiative.

Ann Biomed Eng 2018 Dec 13. Epub 2018 Dec 13.

Department of Applied Physics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland.

Currently, there are no clinically available tools or applications which could predict osteoarthritis development. Some computational models have been presented to simulate cartilage degeneration, but they are not clinically feasible due to time required to build subject-specific knee models. Therefore, the objective of this study was to develop a template-based modeling method for rapid prediction of knee joint cartilage degeneration. Read More

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December 2018
3 Reads

Multiplex PCR for the rapid detection of insulin-like growth factor in the Pacific oyster, Crassostrea gigas: a useful indicator for growth assessment.

Mol Biol Rep 2018 Dec 13. Epub 2018 Dec 13.

Department of Marine Bio-Materials & Aquaculture, Pukyong National University, Busan, 48513, South Korea.

Insulin-like growth factor (IGF) expression plays a critical role in the endocrine regulation of proliferation, differentiation, and growth in shellfish as well as in fish. The Pacific oyster, Crassostrea gigas, is a significant aquaculture species that comprises a large percentage of the Korean shellfish industry; moreover, its growth is economically important in aquaculture. However, when measuring the growth rate in shellfish, the soft tissue weight is difficult to determine because of the shell weight. Read More

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December 2018

Primary hypophysitis and other autoimmune disorders of the sellar and suprasellar regions.

Rev Endocr Metab Disord 2018 Dec 13. Epub 2018 Dec 13.

Medicover GmbH, Berlin/Hannover, Germany.

The pituitary gland and the hypothalamus can be affected by autoimmune-mediated structural and functional disruption. These autoimmune-mediated diseases occur more commonly in females and are often found during pregnancy or in the post-partum period. Autoimmune diseases can either affect parts of the pituitary or hypothalamus, or can involve both sellar and suprasellar structures. Read More

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December 2018
1 Read

Bone marrow cell homing to sites of acute tibial fracture: Zr-oxine cell labeling with positron emission tomographic imaging in a mouse model.

EJNMMI Res 2018 Dec 13;8(1):109. Epub 2018 Dec 13.

Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, NIH, Building 10, Room B3B406, Bethesda, MD, 20892-1002, USA.

Background: Bone fracture healing is dependent upon the rapid migration and engraftment of bone marrow (BM) progenitor and stem cells to the site of injury. Stromal cell-derived factor-1 plays a crucial role in recruiting BM cells expressing its receptor CXCR4. Recently, a CXCR4 antagonist, plerixafor, has been used to mobilize BM cells into the blood in efforts to enhance cell migration to sites of injury presumably improving healing. Read More

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December 2018

Hepatic steatosis and reduction in steatosis following bariatric weight loss surgery differs between segments and lobes.

Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.

Liver Imaging Group, Department of Radiology, University of California San Diego, 200 W. Arbor Drive #8756, San Diego, CA, 92103-8756, USA.

Objectives: The purpose of this study was to (1) evaluate proton density fat fraction (PDFF) distribution across liver segments at baseline and (2) compare longitudinal segmental PDFF changes across time points in adult patients undergoing a very low-calorie diet (VLCD) and subsequent bariatric weight loss surgery (WLS).

Methods: We performed a secondary analysis of data from 118 morbidly obese adult patients enrolled in a VLCD-WLS program. PDFF was estimated using magnitude-based confounder-corrected chemical-shift-encoded (CSE) MRI in each hepatic segment and lobe at baseline (visit 1), after completion of VLCD (visit 2), and at 1, 3, and 6 months (visits 3-5) following WLS. Read More

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December 2018

Development of a microdevice for facile analysis of theophylline in whole blood by a cloned enzyme donor immunoassay.

Lab Chip 2018 Dec 14. Epub 2018 Dec 14.

Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan and ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan and Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu 761-0395, Japan.

We have developed a microdevice for therapeutic drug monitoring. In this device, dispensing of sample and reagent was accomplished by simple manual operation of a syringe. Moreover, for a simple and rapid measurement, we used cloned enzyme donor immunoassay as a detection principle. Read More

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December 2018

Energy Dispersive X-Ray Fluorescence Zn/Fe Ratiometric Determination of Zinc Levels in Expressed Prostatic Fluid: A Direct, Non-Invasive and Highly Accurate Screening for Prostate Cancer.

Acta Sci Cancer Biol 2018 Nov 10;2(9):20-26. Epub 2018 Oct 10.

The Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Maryland, United States of America.

Prostate specific antigen (PSA) does not provide the reliability that is required for the accurate urology screening of prostate cancer (PCa). Consequently, there has been a major focus and search for a simple, rapid, direct, preferably non-invasive, and highly accurate biomarker and procedure for the urology screening for prostate cancer. Virtually all PCa cases exhibit a marked decrease in zinc in prostate tissue and in prostatic fluid. Read More

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November 2018

Design of a 3D navigation template to guide the screw trajectory in spine: a step-by-step approach using Mimics and 3-Matic software.

J Spine Surg 2018 Sep;4(3):645-653

Department of Spine Surgery, Digital Orthopedic Institute, Orthopedic Hospital, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Second Medical College of Wenzhou Medical University, Zhejiang Spine Surgery Center, Wenzhou 325027, China.

Rapid development of 3D printing techniques has led to the design of navigation templates to assist with accurate insertion of pedicle screws in last decades. However, there are still without the precise step-by-step methods to design 3D navigation templates from computed tomography (CT) images. Our present article provides a detailed protocol to allow the readers or researchers to obtain the 3D navigation template easily, and assist with pedicle screw insertion in their future research and surgery. Read More

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September 2018

Dataset of single bacteria cells with different antibiotic susceptibility obtained by Raman spectroscopy.

Data Brief 2018 Dec 23;21:2430-2434. Epub 2018 Nov 23.

Immanuel Kant Baltic Federal University, A. Nevskogo St. 14, 236016 Kaliningrad, Russia.

This data article contains Raman experimental data, obtained with Horiba Jobin-Yvon LabRam HR800 spectrometer (Japan), which can be used for rapid identification of () bacteria (Beijing clade) . Data present analyzed Raman spectra of bacterial cells with various drug resistances obtained from pulmonary and extra pulmonary samples. Data can provide information about characteristic maxima of different structures in biological cell. Read More

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December 2018

Electronic nose dataset for beef quality monitoring in uncontrolled ambient conditions.

Data Brief 2018 Dec 22;21:2414-2420. Epub 2018 Nov 22.

Biology Department, Institut Teknologi Sepuluh Nopember, Jalan Raya ITS, Keputih, Sukolilo, 60111 Surabaya, East Java, Indonesia.

In recent years, the development of a rapid, simple, and low-cost meat assessment system using an electronic nose (e-nose) has been the concern of researchers. In this data article, we provide a time series dataset that was obtained from a beef quality monitoring experiment using an e-nose in uncontrolled ambient conditions. The availability of this dataset will enable discussion on how to deal with noisy e-nose signals and non-optimum sensor array in beef quality monitoring. Read More

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December 2018
2 Reads

Dataset on significant role of Candesartan on cognitive functions in rats having memory impairment induced by electromagnetic waves.

Data Brief 2018 Dec 26;21:2390-2394. Epub 2018 Nov 26.

Rammal Hassan Rammal Research Laboratory, Physio-toxicity (PhyTox) research group, Lebanese University, Faculty of Sciences (V), Nabatieh, Lebanon.

Rapid growing of mobile phones users has raised about the possible effects of these electromagnetic waves (EMW) on human health. Many studies have examined the role of these EMW on biological systems, but the results are still contradictory and controversial. In addition to EMW, over-activation of angiotensin type 1 receptor (AT1R) has been associated with cognitive decline, incidence and progression of neurodegenerative diseases. Read More

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December 2018

Biochemical Characterization of AroH, a Putative Aromatic Amino Acid Aminotransferase.

Front Mol Biosci 2018 28;5:104. Epub 2018 Nov 28.

Department of Experimental Medicine, University of Perugia, Perugia, Italy.

The rise in the frequency of nosocomial infections is becoming a major problem for public health, in particular in immunocompromised patients. is an opportunistic fungus normally present in the environment directly responsible for lethal invasive infections. Recent results suggest that the metabolic pathways related to amino acid metabolism can regulate the fungus-host interaction and that an important role is played by enzymes involved in the catabolism of L-tryptophan. Read More

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November 2018

Targeted Loop-Mediated Isothermal Amplification (LAMP) Assay for Consensus Detection of Mycobacteria Associated With Pulmonary Infections.

Front Med (Lausanne) 2018 28;5:332. Epub 2018 Nov 28.

Aix-Marseille Université, IRD 198, MEPHI, IHU Méditerranée Infection, Marseille, France.

Loop-mediated isothermal amplification (LAMP) is a nucleic acid method which has been used to identify mycobacteria including in clinical microbiology laboratory and point of care settings. Previously published LAMP protocols for detection of mycobacterial species used conventional specific primer and targeted the 16S rRNA, , and insertion sequence genes. We developed and evaluated a LAMP assay targeting a mycobacterial gene conserved sequence and incorporating degenerate primers. Read More

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November 2018

Apocrine gland anal sac adenocarcinoma with perineural metastasis in a cat.

JFMS Open Rep 2018 Jul-Dec;4(2):2055116918815323. Epub 2018 Dec 3.

Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, USA.

Case Summary: A 15-year-old female spayed domestic shorthair cat was presented for hyporexia and acute development of L4-Cd myelopathy (urinary incontinence, pelvic limb paresis with hyporeflexia and absent tail tone). Humane euthanasia was elected owing to the rapid neurological deterioration and necropsy was performed. Post-mortem examination identified a right-sided anal sac mass and medial iliac lymphadenopathy. Read More

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December 2018

Development of Fangjiomics for Systems Elucidation of Synergistic Mechanism Underlying Combination Therapy.

Comput Struct Biotechnol J 2018 20;16:565-572. Epub 2018 Nov 20.

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.

The rapid development of omics technology provides an opportunity for fulfilling the understanding of the synergistic mechanism of combination therapy. However, a systems theory to analyze synergy remains an ongoing challenge. Fangjiomics is a novel systems science based on a holistic theory integrated with reductionism which has been utilized to systematically elucidate the synergistic mechanisms underlying combination therapy using multi-target-, pathway- or network-based quantitative methods. Read More

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November 2018

Sustainable food systems-a health perspective.

Sustain Sci 2018 12;13(6):1505-1517. Epub 2018 Jun 12.

7Departments of Population Health and of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, UK.

Malnutrition in all forms, ranging from undernourishment to obesity and associated diet-related diseases, is one of the leading causes of death worldwide, while food systems often have major environmental impacts. Rapid global population growth and increases in demands for food and changes in dietary habits create challenges to provide universal access to healthy food without creating negative environmental, economic, and social impacts. This article discusses opportunities for and challenges to sustainable food systems from a human health perspective by making the case for avoiding the transition to unhealthy less sustainable diets (using India as an exemplar), reducing food waste by changing consumer behaviour (with examples from Japan), and using innovations and new technologies to reduce the environmental impact of healthy food production. Read More

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Neutrophil Mechanosignaling Promotes Integrin Engagement With Endothelial Cells and Motility Within Inflamed Vessels.

Front Immunol 2018 28;9:2774. Epub 2018 Nov 28.

Simon Lab, Department of Biomedical Engineering, University of California, Davis, Davis, CA, United States.

Neutrophils are the most motile of mammalian cells, a feature that enables them to protect the host against the rapid spread of pathogens from tissue into the circulatory system. A critical process is the recruitment of neutrophils to inflamed endothelium within post-capillary venules. This occurs through cooperation between at least four families of adhesion molecules and G-protein coupled signaling receptors. Read More

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November 2018

Work and Organizational Psychology Looks at the Fourth Industrial Revolution: How to Support Workers and Organizations?

Front Psychol 2018 28;9:2365. Epub 2018 Nov 28.

Department of Psychology, University of Turin, Turin, Italy.

With rapid advances in technology in several fields of human life, we are entering the Fourth Industrial Revolution (FIR), which is changing the way businesses create value, people do their work and individuals interact and communicate with each other. In this framework, many questions have arisen about how these transformations affect workers, organizations and societies, and Work and Organizational Psychology (WOP) has been called upon to address some of these open issues. In particular, this article focuses on two aspects of the FIR. Read More

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November 2018

Linking Cognitive Measures of Response Inhibition and Reward Sensitivity to Trait Impulsivity.

Front Psychol 2018 28;9:2306. Epub 2018 Nov 28.

Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Impulsivity is regarded as a multifaceted construct that comprises two dimensions: rapid-response impulsivity and reward-delay impulsivity. It is unclear, however, which aspects of trait impulsivity, as assessed by self-report measures are related to rapid-response impulsivity and/or to reward-delay impulsivity, as different results have been reported in studies using both self-report and cognitive measures. This study aimed to directly relate self-report measures of impulsivity to cognitive measures of impulsivity in individuals at low- or high-levels on two impulsivity dimensions, specifically rapid-response impulsivity and reward-delay impulsivity. Read More

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November 2018
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A prototype handheld X-ray diffraction instrument.

Authors:
Graeme Hansford

J Appl Crystallogr 2018 Dec 25;51(Pt 6):1571-1585. Epub 2018 Oct 25.

University of Leicester, Space Research Centre, Department of Physics and Astronomy, Leicester LE1 7RH, UK.

A conceptual design for a handheld X-ray diffraction (HHXRD) instrument is proposed. Central to the design is the application of energy-dispersive XRD (EDXRD) in a back-reflection geometry. This technique brings unique advantages which enable a handheld instrument format, most notably, insensitivity to sample morphology and to the precise sample position relative to the instrument. Read More

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December 2018

Complete Recovery of Oxysterol 7α-Hydroxylase Deficiency by Living Donor Transplantation in a 4-Month-Old Infant: the First Korean Case Report and Literature Review.

J Korean Med Sci 2018 Dec 22;33(51):e324. Epub 2018 Nov 22.

Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.

Oxysterol 7α-hydroxylase deficiency is a very rare liver disease categorized as inborn errors of bile acid synthesis, caused by mutations. As it may cause rapid progression to end-stage liver disease even in early infancy, a high index of suspicion is required to prevent fatal outcomes. We describe the case of a 3-month-old boy with progressive cholestatic hepatitis and severe hepatic fibrosis. Read More

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December 2018

Anakinra in Still's disease: a profile of its use.

Drugs Ther Perspect 2018 31;34(12):543-553. Epub 2018 Oct 31.

Springer, Private Bag 65901, Mairangi Bay, 0754 Auckland, New Zealand.

The EU indication for anakinra has been extended to include Still's disease, a serious rare inflammatory disorder of unknown aetiology that comprises adult-onset Still's disease (AOSD) and systemic juvenile idiopathic arthritis (SJIA). As activated interleukin-1 pathways are associated with the systemic manifestations of these disorders, targeted treatment with anakinra, an interleukin-1 inhibitor, has been investigated. Across clinical and real-world studies in patients with AOSD and SJIA, treatment with anakinra achieved clinical remission/response, provided rapid and sustained improvements in systemic and laboratory manifestations, and allowed the use of corticosteroid- and disease-modifying anti-rheumatic drugs (DMARD) to be reduced or discontinued. Read More

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October 2018

Long-range transport of radiocaesium derived from global fallout and the Fukushima accident in the Pacific Ocean since 1953 through 2017-Part I: Source term and surface transport.

Authors:
Michio Aoyama

J Radioanal Nucl Chem 2018 19;318(3):1519-1542. Epub 2018 Oct 19.

Institute of Environmental Radioactivity, Fukushima University, Fukushima, 960-1296 Japan.

Long range transport of radiocaesium derived from local fallout occurred early 1950s, global fallout which occurred mainly late 1950s and early 1960s and the Fukushima accident occurred in 2011 were investigated and presented for ocean surface in the Pacific Ocean. HAM database and its update were used in this study to present whole history of radioccaesium transport in surface layer in the interested region. Since both the main local/global fallout regions and injection of radiocaesium by Fukushima accident occurred in the western North Pacific and constrain of surface current systems which governed surface transport processes were subtropical gyre and subarctic gyre, radiocaesium transport in surface water in the mid latitude was characterized as rapid eastward transport along Kuroshio and Kuroshio extension. Read More

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October 2018

Normotensive non-dipping blood pressure profile does not predict the risk of chronic kidney disease progression.

Hypertens Res 2018 Dec 13. Epub 2018 Dec 13.

Department of Nephrology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

The lack of a decrease in nocturnal blood pressure is a risk factor for the progression of chronic kidney disease (CKD); however, it currently remains unknown whether it is a risk factor in normotensive CKD patients. We conducted a retrospective cohort study and enrolled 676 CKD patients who underwent ambulatory blood pressure monitoring (ABPM). According to their nocturnal blood pressure dipping pattern (>10%: dipper or <10%: non-dipper) and average 24-h systolic blood pressure (>130/80 mmHg: hypertension or <130/80 mmHg: normotension), patients were divided into four groups. Read More

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December 2018

REASSURED diagnostics to inform disease control strategies, strengthen health systems and improve patient outcomes.

Nat Microbiol 2019 Jan 13;4(1):46-54. Epub 2018 Dec 13.

London School of Hygiene and Tropical Medicine, London, England.

Lack of access to quality diagnostics remains a major contributor to health burden in resource-limited settings. It has been more than 10 years since ASSURED (affordable, sensitive, specific, user-friendly, rapid, equipment-free, delivered) was coined to describe the ideal test to meet the needs of the developing world. Since its initial publication, technological innovations have led to the development of diagnostics that address the ASSURED criteria, but challenges remain. Read More

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January 2019

An automated bacterial concentration and recovery system for pre-enrichment required in rapid Escherichia coli detection.

Sci Rep 2018 Dec 13;8(1):17808. Epub 2018 Dec 13.

Jiangsu Delin Environmental Protection Technology Co., Ltd., Jiangsu, China.

One of the biggest challenges in rapid low concentration bacterial detection is the pre-concentration or pre-enrichment, which aims to increase bacteria concentration and reduce sample volume for easy bacterial detection. In practical bacterial detection, large-volume water samples with a pathogenic bacterial concentration of less than 1 CFU/mL have to be tested rapidly. The reported biosensors either have insufficient detection limit or have limited capability of handling a sufficiently large water sample. Read More

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December 2018

Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides.

Nat Commun 2018 Dec 13;9(1):5297. Epub 2018 Dec 13.

State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, 200237, Shanghai, China.

Polypeptides have broad applications and can be prepared via ring-opening polymerization of α-amino acid N-carboxyanhydrides (NCAs). Conventional initiators, such as primary amines, give slow NCA polymerization, which requires multiple days to reach completion and can result in substantial side reactions, especially for very reactive NCAs. Moreover, current NCA polymerizations are very sensitive to moisture and must typically be conducted in a glove box. Read More

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December 2018

Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization and consequent inhibition of mTORC1 activity.

Cell Death Dis 2018 Dec 13;9(12):1191. Epub 2018 Dec 13.

The Fred Wyszkowski Cancer Research Laboratory, Technion-Israel Institute of Technology, Haifa, Israel.

Transcription factor EB (TFEB) is a master transcriptional regulator playing a key role in lysosomal biogenesis, autophagy and lysosomal exocytosis. TFEB activity is inhibited following its phosphorylation by mammalian target of rapamycin complex 1 (mTORC1) on the surface of the lysosome. Phosphorylated TFEB is bound by 14-3-3 proteins, resulting in its cytoplasmic retention in an inactive state. Read More

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December 2018

Dynamic microtubules drive fibroblast spreading.

Biol Open 2018 Dec 13;7(12). Epub 2018 Dec 13.

Department of Electron Microscopy, A.N. Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov State University, 1-40 Leninskie Gory, Moscow 119991, Russia

When cells with a mesenchymal type of motility come into contact with an adhesive substrate they adhere and start spreading by the formation of lamellipodia. Using a label-free approach and virtual synchronization approach we analyzed spreading in fibroblasts and cancer cells. In all cell lines spreading is a non-linear process undergoing isotropic or anisotropic modes with first fast (5-20 min) and then slow (30-120 min) phases. Read More

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December 2018

The DNA repair associated protein Gadd45 regulates the temporal coding of immediate early gene expression within the prelimbic prefrontal cortex and is required for the consolidation of associative fear memory.

J Neurosci 2018 Dec 13. Epub 2018 Dec 13.

Cognitive Neuroepigenetics Laboratory, Queensland Brain Institute, The University of Queensland, St Lucia, QLD 4072, Australia

We have identified a member of the growth arrest and DNA damage (Gadd45) protein family, Gadd45, which is known to be critically involved in DNA repair, as a key player in the regulation of immediate early gene (IEG) expression underlying the consolidation of associative fear memory in adult male C57/Bl6 mice. Gadd45 temporally influences learning-induced IEG expression in the prelimbic prefrontal cortex (PLPFC) through its interaction with DNA double-strand break (DSB)-mediated changes in DNA methylation. Our findings suggest a two-hit model of experience-dependent IEG activity and learning that comprises 1) a first wave of IEG expression governed by DSBs and followed by a rapid increase in DNA methylation, and 2) a second wave of IEG expression associated with the recruitment of Gadd45 and active DNA demethylation at the same site, which is necessary for memory consolidation. Read More

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December 2018

High-capacity preconscious processing in concurrent groupings of colored dots.

Proc Natl Acad Sci U S A 2018 Dec 13. Epub 2018 Dec 13.

Department of Cognitive Sciences, University of California, Irvine, CA 92697

Grouping is a perceptual process in which a subset of stimulus components (a group) is selected for a subsequent-typically implicit-perceptual computation. Grouping is a critical precursor to segmenting objects from the background and ultimately to object recognition. Here, we study grouping by color. Read More

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December 2018

Issues in Building a Nursing Home Syndromic Surveillance System with Textmining: Longitudinal Observational Study.

JMIR Public Health Surveill 2018 Dec 13;4(4):e69. Epub 2018 Dec 13.

Equipe de recherche (HANDIReSP), UFR des Sciences de la Santé Simone Veil, Université de Versailles Saint-Quentin-en-Yvelines et Université Paris-Saclay, Montigny-le-Bretonneux, France.

Background: New nursing homes (NH) data warehouses fed from residents' medical records allow monitoring the health of elderly population on a daily basis. Elsewhere, syndromic surveillance has already shown that professional data can be used for public health (PH) surveillance but not during a long-term follow-up of the same cohort.

Objective: This study aimed to build and assess a national ecological NH PH surveillance system (SS). Read More

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December 2018

Website Analytics of a Google Ads Campaign for a Men's Mental Health Website: Comparative Analysis.

JMIR Ment Health 2018 Dec 13;5(4):e12428. Epub 2018 Dec 13.

College of Pharmacy, Faculty of Health, Dalhousie University, Halifax, NS, Canada.

Background: Men with mental health and addictions problems seek information and help from health service providers and community support less often than women with such problems. Online health resources offer men rapid access to self-care recommendations and resources and anonymity; however, only a few websites are specifically developed for men. Headstrong - Taking Things Head-On was a community pharmacy and online health promotion initiative for men living with mental health and addictions problems. Read More

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December 2018
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Elements of Trust in Digital Health Systems: Scoping Review.

J Med Internet Res 2018 Dec 13;20(12):e11254. Epub 2018 Dec 13.

Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.

Background: Information and communication technologies have long become prominent components of health systems. Rapid advances in digital technologies and data science over the last few years are predicted to have a vast impact on health care services, configuring a paradigm shift into what is now commonly referred to as digital health. Forecasted to curb rising health costs as well as to improve health system efficiency and safety, digital health success heavily relies on trust from professional end users, administrators, and patients. Read More

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December 2018
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A combined mono- and multi-turbine approach for fault indicator synthesis and wind turbine monitoring using SCADA data.

ISA Trans 2018 Dec 5. Epub 2018 Dec 5.

University Grenoble Alpes, CNRS, Grenoble INP, GIPSA-lab, F-38000 Grenoble, France. Electronic address:

The monitoring of wind turbines using SCADA data has received lately a growing interest from the fault diagnosis community because of the very low cost of these data, which are available in number without the need for any additional sensor. Yet, these data are highly variable due to the turbine constantly changing its operating conditions and to the rapid fluctuations of the environmental conditions (wind speed and direction, air density, turbulence, …). This makes the occurrence of a fault difficult to detect. Read More

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December 2018

Analysis of Trends in Insulin Utilization and Spending Across Canada From 2010 to 2015.

Can J Diabetes 2018 Aug 16. Epub 2018 Aug 16.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. Electronic address:

Objectives: To describe insulin utilization and spending across Canada and investigate how interprovincial variations in long-acting insulin uptake impact provincial spending.

Methods: We conducted a cross-sectional time-series analysis of insulin products dispensed nationally from January 1, 2010, to December 31, 2015, using data from IQVIA (Durham, North Carolina, United States). Analysis was stratified according to insulin type, payer and province. Read More

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The early prognostic value of inflammatory markers in patients with acute pancreatitis.

Clin Res Hepatol Gastroenterol 2018 Dec 10. Epub 2018 Dec 10.

Department of Pancreatic Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan city, Hubei province 430060, PR China. Electronic address:

Objectives: The aim of this study was to compare the prognostic value of inflammation-based prognostic markers with the more mature scoring system BISAP in patients with AP and identify the best predictors.

Patients And Methods: We retrospectively analysed the data of patients with AP who were treated in our hospital from January 2017 to March 2018 and compared the prognostic value of these inflammation-based prognostic markers with the BISAP score in patients with AP.

Results: Higher BISAP score, NLR, PLR, ACC, and BUN gradually increased (all P < 0. Read More

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December 2018
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Ephrin type-B receptor 4 affinity chromatography: An effective and rapid method studying the active compounds targeting Ephrin type-B receptor 4.

J Chromatogr A 2018 Dec 4. Epub 2018 Dec 4.

School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, PR China. Electronic address:

Erythropoietin-producing hepatocyte B4 (EphB4) has recently been reported to be an oncogenic factor in many cancers and overexpressed in several types of tumors. Thus, EphB4 has the potential to be a therapeutic target in these malignancies. High-performance affinity chromatography has been a powerful tool to study the interaction between drugs and receptors. Read More

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December 2018

Differences in the characteristics, treatment, and outcomes of patient groups reviewed by intensive care liaison nurses in Australia: A multicentre prospective study.

Aust Crit Care 2018 Dec 10. Epub 2018 Dec 10.

Intensive Care Unit, Austin Health, 145 Studley Road, Heidelberg, Victoria, 3084, Australia.

Background: There is a lack of knowledge about tasks intensive care unit liaison nurses (ICU LNs) perform during patient review, despite this role operating in at least 31 acute care hospitals in Australia.

Objectives: To evaluate the tasks that ICU LNs perform during patient review in the following referral subcategories: review after ICU discharge, rapid response team (RRT) review, and ward referral.

Methods: A 2-month prospective observational study using standardised case report forms to collect data on patients reviewed by ICU LNs in 20 Australian hospitals was conducted. Read More

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December 2018

Environmental characteristics of a tundra river system in Svalbard. Part 1: Bacterial abundance, community structure and nutrient levels.

Sci Total Environ 2018 Nov 28. Epub 2018 Nov 28.

Department of Analytical Chemistry, Faculty of Chemistry, Gdansk University of Technology, 11/12 Narutowicza St., Gdansk 80-233, Poland. Electronic address:

The Arctic hosts a set of unique ecosystems, characterised by extreme environmental conditions and undergoing a rapid change resulting from the average temperature rising. We present a study on an aquatic ecosystem of the Revelva catchment (Spitsbergen), based on samples collected from the lake, river and their tributaries, in the summer of 2016. The landscape variety of the study site and the seasonal change in the hydrological regime modify the availability of nutrients. Read More

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November 2018

Comparison of fourteen rule-out strategies for acute myocardial infarction.

Int J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Switzerland; GREAT network. Electronic address:

Background: The clinical availability of high-sensitivity cardiac troponin (hs-cTn) has enabled the development of several innovative strategies for the rapid rule-out of acute myocardial infarction (AMI). Due to the lack of direct comparisons, selection of the best strategy for clinical practice is challenging.

Methods: In a prospective international multicenter diagnostic study enrolling 3696 patients presenting with suspected AMI to the emergency department, we compared the safety and efficacy of 14 different hs-cTn-based strategies: hs-cTn concentrations below the limit of detection (LoD), dual-marker combining hs-cTn with copeptin, ESC 0 h/1 h-algorithm, 0 h/2 h-algorithm, 2 h-ADP-algorithm, NICE-algorithm, and ESC 0 h/3 h-algorithm, each using either hs-cTnT or hs-cTnI. Read More

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December 2018
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High-throughput screening of bacterial pathogens in clinical specimens using 16S rDNA qPCR and fragment analysis.

Diagn Microbiol Infect Dis 2018 Nov 20. Epub 2018 Nov 20.

Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.

Molecular-based detection of bacterial pathogens directly from clinical specimens permits rapid initiation of effective antimicrobial treatment and adequate patient management. Broad-range polymerase chain reaction (PCR) amplification of the 16S rRNA gene (16S rDNA qPCR) is used in many diagnostic laboratories as a complement to cultural identification of bacterial pathogens. However, efforts for automation of 16S rDNA PCR workflows are needed in order to reduce turnaround times and to enhance reproducibility and standardization of the technique. Read More

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November 2018

Clinical utility and limitations of FibCare® for the rapid measurement of fibrinogen concentrations: The first clinical experience.

Taiwan J Obstet Gynecol 2018 Dec;57(6):899-900

Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

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December 2018

The Use of Codeine and Tramadol in the Pediatric Population-What is the Verdict Now?

J Pediatr Health Care 2019 Jan;33(1):117-123

Codeine and tramadol are opioid analgesics approved for the management of pain in the United States. Both agents are metabolized in the liver to active compounds via the cytochrome P450 2D6 enzyme. Case reports of pediatric patients with overactive CYP2D6 enzymes have been reported. Read More

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January 2019
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Symtuza in clinical practice.

Enferm Infecc Microbiol Clin 2018 Dec;36 Suppl 2:31-36

Departamento de Enfermedades Infecciosas, Hospital Ramón y Cajal, Madrid.

Because lifelong therapy is needed in HIV infection, high long-term adherence is necessary. Darunavir/co-bicistat/emtricitabina/tenofovir alafenamide (Symtuza) is the first triple therapy combining a protease inhibitor (PI) in a single tablet regimen. This drug combines the potency and high genetic barrier of the most effective PI, darunavir, with the renal and bone safety of tenofovir alafenamide. Read More

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December 2018

Characterization and functional biology of the soybean aleurone layer.

BMC Plant Biol 2018 Dec 13;18(1):354. Epub 2018 Dec 13.

School of Plant Sciences/BIO5 Institute/University of Arizona, 1657 E. Helen St, Tucson, AZ, 85721, USA.

Background: Soybean is a globally important oil seed crop. Both the high protein and oil content of soybean seeds make this crop a lucrative commodity. As in higher eukaryotic species with available genomes, the functional annotation of most of soybean's genes still remains to be investigated. Read More

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December 2018

Comparative genomic analysis revealed rapid differentiation in the pathogenicity-related gene repertoires between Pyricularia oryzae and Pyricularia penniseti isolated from a Pennisetum grass.

BMC Genomics 2018 Dec 13;19(1):927. Epub 2018 Dec 13.

State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.

Background: A number of Pyricularia species are known to infect different grass species. In the case of Pyricularia oryzae (syn. Magnaporthe oryzae), distinct populations are known to be adapted to a wide variety of grass hosts, including rice, wheat and many other grasses. Read More

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December 2018

Therapist effects on early change in psychotherapy in a naturalistic setting.

Psychother Res 2018 Dec 14:1-11. Epub 2018 Dec 14.

a Counseling and Psychological Services , Brigham Young University , Provo , UT , USA.

Objective: Client trajectories of change in psychotherapy differ. Early change is a trajectory that has been shown to be associated with better outcomes over time. Little is known about the mechanisms of this type of change, however. Read More

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December 2018
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