8,481 results match your criteria Rapid Communications in Mass Spectrometry[Journal]


Characterization of Ethoxylated Alcohols in Friction Reducers using Matrix-Assisted Laser Desorption/Ionization - Time-of-Flight - Mass Spectrometry.

Rapid Commun Mass Spectrom 2019 Apr 22. Epub 2019 Apr 22.

Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX, USA.

Rationale: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) provides detailed information for the analysis of ethoxylated alcohols and polymers. In this study, five friction reducers used in commercial hydraulic fracturing processes were analyzed in their as-received form to identify their ethoxylated alcohol content. The friction reducers were then subjected to lab-simulated downhole conditions. Read More

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http://dx.doi.org/10.1002/rcm.8468DOI Listing

Rapid profiling of triglycerides in human breast milk using LESA-FTMS reveals new VLCFAs and differences within individuals.

Rapid Commun Mass Spectrom 2019 Apr 22. Epub 2019 Apr 22.

Nutrition and Bone Health group MRC HNR, Cambridge, CB1 9NL, United Kingdom.

Rationale: In this paper, we describe a novel method for preparing milk samples and profiling the triglyceride fraction from them. This method was used to explore how the triglyceride (TG) profile of milk modulates as lactation progresses and how the TG profile differs between breasts.

Methods: Fresh milk was spotted onto Whatman filter paper and air-dried. Read More

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http://dx.doi.org/10.1002/rcm.8465DOI Listing
April 2019
1 Read

Sequential measurement of δ N, δ C and δ S values in archaeological bone collagen at the Scottish Universities Environmental Research Centre (SUERC): a new analytical frontier.

Rapid Commun Mass Spectrom 2019 Apr 16. Epub 2019 Apr 16.

Scottish Universities Environmental Research Centre, Scottish Enterprise Technology Park, Rankine Avenue, East Kilbride, G75 0QF, UK.

Rationale: The use of multi-isotopic analysis (δ N, δ C and δ S values) of archaeological bone collagen to assist in the interpretation of diet, movement and mobility of prehistoric populations is gradually increasing, yet many researchers have traditionally avoided investigating sulphur due to its very low concentrations (<0.3%) in mammalian collagen. For this reason, and as a consequence of analytical detection limits, sulphur is usually measured separately from carbon and nitrogen, which leads to longer analytical times and higher costs. Read More

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http://dx.doi.org/10.1002/rcm.8462DOI Listing

Calibrating temperature reconstructions from fish otolith oxygen isotope analysis for California's critically-endangered Delta Smelt.

Rapid Commun Mass Spectrom 2019 Apr 16. Epub 2019 Apr 16.

Wildlife, Fish and Conservation Biology, UC Davis, One Shields Avenue, Davis, CA, 95616, USA.

Rationale: Oxygen isotope ratios (δ O values) of fish otoliths (ear bones) are valuable geochemical tracers of water conditions and thermal life history. Delta Smelt (Hypomesus transpacificus) are osmerid forage fish endemic to the San Francisco Estuary, California, USA and are on the verge of extinction. These fish exhibit a complex life history that allows them to survive in a dynamic estuarine environment; however, a rapidly warming climate threatens this thermally-sensitive species. Read More

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http://dx.doi.org/10.1002/rcm.8464DOI Listing
April 2019
2.253 Impact Factor

Boron isotope variability related to B speciation (change during uptake and transport) in bell pepper plants and SI traceable n( B)/n( B) ratios for plant reference materials.

Rapid Commun Mass Spectrom 2019 Apr 15. Epub 2019 Apr 15.

University of Applied Sciences Erfurt, Leipziger Str. 77, 99085, Erfurt, Germany.

Rationale: Boron (B) is an essential micronutrient in plants and its isotope variations are used to gain insights into plant metabolism, which is important for crop plant cultivation. B isotope variations were used to trace intraplant fractionation mechanisms in response to the B concentration in the irrigation water spanning the range from B depletion to toxic levels.

Methods: A fully validated analytical procedure based on MC-ICP-MS, sample decomposition and B matrix separation was applied to study B isotope fractionation. Read More

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http://dx.doi.org/10.1002/rcm.8455DOI Listing

Fast and precise boron isotopic analysis of carbonates and seawater using Nu Plasma II MC-ICPMS and simple sample introduction system.

Rapid Commun Mass Spectrom 2019 Apr 15. Epub 2019 Apr 15.

Department of Earth and Space Sciences, University of Washington, Seattle, WA, 98195, USA.

Rationale: The boron isotopic composition in marine carbonates provides important insights into paleoclimate reconstruction and biomineralization. However, precise and accurate measurements of B isotopes using plasma-based mass spectrometry is difficult due to the volatile nature of B, which typically requires complex and more specialized sample introduction systems. Existing analytical protocols have mostly been based on Thermo Scientific Neptune Plus MC-ICPMS instruments, whereas methods based on Nu Plasma mass spectrometers are scarce. Read More

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http://dx.doi.org/10.1002/rcm.8456DOI Listing

Characterization of gelsevirine metabolites in rat liver S9 by accurate mass measurements using high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry.

Rapid Commun Mass Spectrom 2019 Apr 15. Epub 2019 Apr 15.

College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, 410128, China.

Rationale: Gelsemium elegans Benth belongs to the family Loganiaceae and is widely distributed in Northern America, East Asia, and Southeast Asia. It has attracted wide attention for its diverse biological effects and complex architectures. Gelsevirine is one of the major components in G. Read More

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http://dx.doi.org/10.1002/rcm.8457DOI Listing
April 2019
1 Read

Enzymatically-catalyzed CO -H O equilibration for oxygen isotope analyses of aqueous samples.

Rapid Commun Mass Spectrom 2019 Apr 15. Epub 2019 Apr 15.

School of Geography and Earth Sciences, McMaster University, 1280 Main Street West, Hamilton, ON, L83 4K1, Canada.

Rationale: The classic CO -H O equilibration method is a very popular technique for the measurement of the oxygen isotope composition of aqueous samples in stable isotope geochemistry. This study examined whether enzymatically-controlled CO -H O equilibration by carbonic anhydrase (CA) could reduce the time for oxygen isotope equilibrium between CO and H O at 25 °C.

Methods: Four types of aqueous samples containing CA were equilibrated with CO gases using a continuous flow isotope ratio mass spectrometer equipped with an automated gas sample collection device. Read More

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http://dx.doi.org/10.1002/rcm.8458DOI Listing

A Ti (III) Reduction Method for One-Step Conversion of Seawater and Freshwater Nitrate to N O for Stable Isotopic Analysis of N/ N, O/ O and O/ O.

Rapid Commun Mass Spectrom 2019 Apr 12. Epub 2019 Apr 12.

School for Marine Science and Technology, University of Massachusetts at Dartmouth, New Bedford, MA, USA.

Rationale: The nitrogen and oxygen (δ N, δ O, and δ O values) isotopic compositions of nitrate (NO ) are crucial tracers of nutrient N sources and dynamics in aquatic systems. Current methods such as bacterial denitrification or Cd-Azide reduction require laborious multi-step conversions or toxic chemicals to reduce NO to N O for N and O isotopic analyses by IRMS. Furthermore, the O composition of N O cannot be directly disentangled using IRMS because O contributes to mass 45 ( N). Read More

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http://dx.doi.org/10.1002/rcm.8454DOI Listing

Practical and theoretical considerations for the determination of δ C values of methylmercury in the environment.

Rapid Commun Mass Spectrom 2019 Apr 10. Epub 2019 Apr 10.

National Measurement Laboratory, LGC Limited, Queens Road, Teddington, TW11 0LY, UK.

Rationale: Analytical methods that can identify the source and fate of mercury and organomecury compounds are likely to be useful tools to investigate mercury in the environment. Carbon isotope ratio analysis of methylmercury (MeHg) together with mercury isotope ratios may offer a robust tool to study environmental cycling of organomercury compounds within fish tissues and other matrices.

Methods: MeHg carbon isotope ratios were determined by gas chromatography/combustion-isotope ratio mass spectrometry (GC/C-IRMS) either directly or following derivatization using sodium tetraethylborate. Read More

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http://dx.doi.org/10.1002/rcm.8453DOI Listing
April 2019
2 Reads

Nucleoside-AuCl4- interactions as studied by electrospray ionization mass spectrometry.

Rapid Commun Mass Spectrom 2019 Apr 9. Epub 2019 Apr 9.

Institute of Chemistry and Technical Electrochemistry, Poznań University of Technology, Berdychowo 4, 60-965, Poznań, Poland.

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http://dx.doi.org/10.1002/rcm.8452DOI Listing
April 2019
2 Reads

Development of a Robotics Platform for Automated Multi-ionization Mass Spectrometry.

Rapid Commun Mass Spectrom 2019 Apr 4. Epub 2019 Apr 4.

MSTM, LLC, Newark, DE, USA.

Rationale: Successful coupling of a multi-ionization automated platform with commercially available mass spectrometers provides improved coverage of compounds in complex mixtures through implementation of new and traditional ionization methods. The versatility of the automated platform is demonstrated through coupling with two different vendors' mass spectrometers. Standards and complex biological samples were acquired using electrospray ionization (ESI), solvent assisted ionization (SAI) and matrix assisted ionization (MAI). Read More

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http://dx.doi.org/10.1002/rcm.8449DOI Listing
April 2019
2 Reads

Measurement precision and accuracy of high artificial enrichment N and C tracer samples.

Rapid Commun Mass Spectrom 2019 Apr 3. Epub 2019 Apr 3.

Institute of Agricultural Sciences, ETH Zurich, Universitätstrasse 2, 8092, Zurich, Switzerland.

Rationale: Oversaturation of the Faraday cup amplifiers of isotope ratio mass spectrometers when using tracers that are highly enriched in heavier isotopes (up to 99.9%) remains a major bottleneck to obtaining high-precision measurements. The memory effect plays a key role in reducing tracer sample measurement precision and accuracy. Read More

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http://dx.doi.org/10.1002/rcm.8451DOI Listing
April 2019
2 Reads

Characterization of curcumin metabolites in rats by ultra-high-performance liquid chromatography with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.

Rapid Commun Mass Spectrom 2019 Apr 3. Epub 2019 Apr 3.

Experiment Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Shanghai, 201210, China.

Rationale: Curcumin is a major constituent of Curcuma longa L. and is a naturally bio-active diketone. Curcumin structural changes have been shown to result in different biological effects. Read More

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http://dx.doi.org/10.1002/rcm.8450DOI Listing
April 2019
12 Reads

Insight into molecular information of Huolinguole lignite obtained by FT-ICR mass spectrometry and statistical methods.

Rapid Commun Mass Spectrom 2019 Apr 2. Epub 2019 Apr 2.

Key Laboratory of Coal Processing and Efficient Utilization, Ministry of Education, China University of Mining & Technology, Xuzhou, 221116, Jiangsu, China.

Rationale: Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) was applied to the characterization of organic compounds in coal extracts at the molecular level. Large volume of data obtained by the FT-ICR MS were processed via statistical methods to extract valuable information on the molecular structure and composition of organic compounds in coal.

Methods: A low-rank coal was subjected to ultrasonic extraction sequentially with six solvents to separate and enrich species with different molecular characteristics. Read More

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http://dx.doi.org/10.1002/rcm.8448DOI Listing
April 2019
9 Reads

Interpretation of bulk nitrogen and carbon isotopes in archaeological foodcrusts on potsherds.

Rapid Commun Mass Spectrom 2019 Mar 28. Epub 2019 Mar 28.

Research Cluster for History of Resource Utilization, Meiji University, Kanda-Surugadai 1-1, Tokyo, 101-8301, Japan.

Rationale: Foodcrust, charred deposit adhering to the surface of containers, is a possible source of information on the function of ancient vessels and the subsistence of prehistoric humans. While the carbon isotope ratios in those materials are useful in detecting the usage of C plants, the reliability of nitrogen isotopic signatures has not been fully investigated.

Methods: The validity of bulk nitrogen isotope ratios has previously been investigated in coastal or riverine environments, where multiple resources from terrestrial and aquatic ecosystems were available, but not in terrestrial settings which provide a simpler mixing of terrestrial animals and plants. Read More

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http://dx.doi.org/10.1002/rcm.8446DOI Listing
March 2019
3 Reads

Direct analysis from DBS cards surface with Direct Probe Mass Spectrometry - evaluation study.

Rapid Commun Mass Spectrom 2019 Mar 28. Epub 2019 Mar 28.

Laboratory for Forensic Chemistry, Department of Analytical Chemistry, Jagiellonian University, 2, Gronostajowa St, 30-387, Kraków, Poland.

Rationale: The Direct Probe Mass Spectrometry (DIPMS) method allows successful analysis of powders, solid and liquid samples. The potential of direct surface analysis could find further application in the examination of surfaces with good absorption properties such as Dried Blood Spot (DBS) cards that constitute a great alternative to classical blood collection method directly from veins.

Methods: DIPMS was performed with the ionization carried under atmospheric pressure in an Atmospheric Pressure Chemical Ionization source. Read More

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http://dx.doi.org/10.1002/rcm.8447DOI Listing
March 2019
1 Read

Identification of protein patterns in bovine placenta at early-mid pregnancy - pilot studies.

Rapid Commun Mass Spectrom 2019 Mar 26. Epub 2019 Mar 26.

Department of Biochemistry, Faculty of Veterinary Medicine, University of Life Science in Lublin, 20-033, Lublin, Akademicka 12, Poland.

Rationale: Placenta is a crucial tissue for an appropriate development of fetus and the course of pregnancy. Its composition and structure changes dynamically along pregnancy but the full pattern of these changes is not fully described in cows yet. The aim of present study was to detect qualitative and quantitative protein profiles of bovine placenta during early-mid pregnancy at the time of placental formation. Read More

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http://dx.doi.org/10.1002/rcm.8444DOI Listing
March 2019
1 Read

Reactive Paper Spray Mass Spectrometry for Rapid Analysis of Formaldehyde in Facial Mask.

Rapid Commun Mass Spectrom 2019 Mar 26. Epub 2019 Mar 26.

Department of Chemistry, Zhejiang University, Hangzhou, 310027, China.

Rationale: A reactive paper spray mass spectrometric approach for rapid analysis of formaldehyde (FA) in cosmetics was developed based on an on-line derivatization reaction between formaldehyde and dansyl hydrazine (DH).

Methods: The whole experimental procedure simply consists of three steps: 1) load the sample (2 μL) onto the paper; 2) add the spray solvent (10 μL DH); 3) apply a high voltage (+4.5 kV) to the sample. Read More

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http://dx.doi.org/10.1002/rcm.8445DOI Listing
March 2019
1 Read

Ionisation bias undermines the use of MALDI for estimating peptide deamidation: synthetic peptide studies demonstrate ESI gives more reliable response ratios.

Rapid Commun Mass Spectrom 2019 Mar 25. Epub 2019 Mar 25.

Department of Chemistry, University of York, York.

Rationale: Although mass spectrometry is routinely used to determine deamination in peptide mixtures, the effects of ionisation source choice have not yet been investigated. In particular, matrix-assisted laser desorption/ionisation (MALDI) has become a popular tool with which to measure levels of glutamine deamidation in ancient proteins. Here we use model synthetic peptides to rigorously compare MALDI and electrospray ionisation. Read More

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http://dx.doi.org/10.1002/rcm.8441DOI Listing
March 2019
1 Read

Characterization of a new component and impurities in josamycin by trap-free two-dimensional liquid chromatography coupled to ion trap time-of-flight mass spectrometry.

Rapid Commun Mass Spectrom 2019 Mar 24. Epub 2019 Mar 24.

Zhejiang University of Technology, Hangzhou, 310014, China.

Rationale: Impurities' toxicities of drug will affect the clinical effect and cause potential health risk, therefore, it is essential to study impurities profiles. In this study a new structural type of component and two acid degradation impurities in josamycin were discovered and characterized for the further improvement of official monographs in pharmacopoeias.

Methods: The component and acid degradation impurities in josamycin were separated and preliminary characterized by a trap-free two-dimensional liquid chromatography coupled to high resolution ion trap time-of-flight mass spectrometry (2D LC/IT-TOF MS) with both positive and negative electrospray ionization modes. Read More

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http://dx.doi.org/10.1002/rcm.8439DOI Listing
March 2019
1 Read

Understanding the performance of a paper-based UV exposure sensor: The photodegradation mechanism of brilliant blue FCF in the presence of TiO photocatalysts in both the solid-state and solution.

Rapid Commun Mass Spectrom 2019 Mar 22. Epub 2019 Mar 22.

School of Chemistry, The University of New South Wales, Sydney, Australia.

Rationale: The decolouration of brilliant blue FCF by the action of TiO under UV exposure has been recently reported as the basis of a paper-based sensor for monitoring UV sun exposure. The mechanism of brilliant blue FCF photodegradation in the presence of the photocatalyst and the resulting photoproducts are thus far unknown.

Methods: The UV initiated photodegradation of brilliant blue FCF in the presence of TiO for both the aqueous and the solid state was investigated. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/rcm.8442
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http://dx.doi.org/10.1002/rcm.8442DOI Listing
March 2019
13 Reads

Recombinant expression, purification and characterization of acetylated LysargiNase from Escherichia coli with high activity and stability.

Rapid Commun Mass Spectrom 2019 Mar 22. Epub 2019 Mar 22.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing) and Beijing Institute of Lifeomics, Beijing, 102206, P. R. China.

Rationale: LysargiNase is a novel characterized metalloprotease that can cleave N-terminal of lysine or arginine residue. The peptides generated by LysargiNase were just mirrors to those by trypsin. This characters of LysargiNase provide a powerful tool for mass spectrometry-based proteomics research. Read More

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http://dx.doi.org/10.1002/rcm.8440DOI Listing
March 2019
1 Read

Characterization of the all-E. coli transcription-translation system myTXTL by mass spectrometry.

Rapid Commun Mass Spectrom 2019 Mar 22. Epub 2019 Mar 22.

School of Physics and Astronomy, University of Minnesota, 115 Union Street SE, Minneapolis, MN, 55455, USA.

Rationale: Cell-free transcription-translation (TXTL) is becoming a popular technology to prototype and engineer biological systems outside living organisms. TXTL relies commonly to a cytoplasmic extract that provides the molecular components necessary to recapitulate gene expression in vitro, where most of the available systems are derived from E. coli. Read More

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http://dx.doi.org/10.1002/rcm.8438DOI Listing
March 2019
1 Read

Ion Mobility - Mass Spectrometry: Small molecule applications.

Authors:
Filip Cuyckens

Rapid Commun Mass Spectrom 2019 Mar 20. Epub 2019 Mar 20.

Drug Metabolism & Pharmacokinetics, Janssen R&D, Turnhoutseweg 30, Beerse.

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http://dx.doi.org/10.1002/rcm.8443DOI Listing
March 2019
1 Read

In Silico, In vitro and In vivo Metabolite Identification of Brexpiprazole using Ultra High Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry.

Rapid Commun Mass Spectrom 2019 Mar 19. Epub 2019 Mar 19.

National Institute of Pharmaceutical Education and Research-Ahmedabad, Palaj, Gandhinagar, Gujarat, 382355, India.

Rationale: Brexpiprazole is a novel serotonin-dopamine activity modulator approved by USFDA in July 2015 for the treatment of schizophrenia and as an adjunctive therapy with other antidepressants for major depressive disorder in adults. However, limited numbers of metabolites are reported in literature for brexpiprazole. Our prime intent behind this study is to revisit metabolite profiling of brexpiprazole and to identify and characterize all possible in vitro and in vivo metabolites. Read More

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http://dx.doi.org/10.1002/rcm.8436DOI Listing
March 2019
2 Reads

Investigation of the crucial factors affecting accurate measurement of strontium isotope ratios by total evaporation thermal ionization mass spectrometry.

Rapid Commun Mass Spectrom 2019 May;33(9):857-866

National Institute of Metrology, Beijing, 100029, People's Republic of China.

Rationale: An absolute method that does not require calibration is very important in several areas of isotope analysis due to the shortage of suitable certified reference materials (CRMs). As total evaporation thermal ionization mass spectrometry (TE-TIMS) theoretically overcomes mass fractionation through integrating the ion currents till the sample on the filament is completely exhausted, it could be an absolute method that does not require the use of CRMs for calibration. However, the lack of reliable method verification and reasonable uncertainty evaluation restricts its extensive application, and these effects need to be quantitatively evaluated. Read More

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http://dx.doi.org/10.1002/rcm.8410DOI Listing
May 2019
2 Reads

Identification of N-terminal protein processing sites by chemical labeling mass spectrometry.

Rapid Commun Mass Spectrom 2019 Mar 18. Epub 2019 Mar 18.

School of Informatics, Computing, and Engineering, Indiana University, Bloomington.

Rationale: Proteins undergo post-translational modifications and proteolytic processing that can affect their biological function. Processing often involves the loss of single residues. Cleavage of signal peptides from the N-terminus is commonly associated with translocation. Read More

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http://dx.doi.org/10.1002/rcm.8435DOI Listing
March 2019
1 Read

Measurement of O O and O O in atmospheric O using the 253 Ultra mass spectrometer and applications to stratospheric and tropospheric air samples.

Rapid Commun Mass Spectrom 2019 Mar 18. Epub 2019 Mar 18.

Institute for Marine and Atmospheric Research Utrecht, Utrecht University, The Netherlands.

Rationale: The doubly-substituted isotopologues (e.g., O O, O O) in atmospheric O are potential tracers for ozone photochemistry and atmospheric temperatures. Read More

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http://dx.doi.org/10.1002/rcm.8434DOI Listing
March 2019
2 Reads

Matrix assisted ionization mass spectrometry in targeted protein analysis - an initial evaluation.

Rapid Commun Mass Spectrom 2019 Mar 18. Epub 2019 Mar 18.

Section of Pharmaceutical Chemistry, Department of Pharmacy, University of Oslo, Norway.

Rationale: Matrix assisted ionization (MAI) is a relatively new ionization technique for analysis by mass spectrometry (MS). The technique is simple and has been shown to be less influenced by matrix effects than e.g. Read More

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http://dx.doi.org/10.1002/rcm.8437DOI Listing
March 2019
2 Reads

Shoot δ C values as an indicator of cumulative stress: the role of re-watering during drought and salinity stress.

Rapid Commun Mass Spectrom 2019 Mar 13. Epub 2019 Mar 13.

College of Grassland Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, China.

Rationale: The plant carbon stable isotope composition (δ C value) can reflect prolonged drought and salinity, as different isotopic signal resulting from drought and salinity can be retained in plant tissue. Commonly, drought and salinity are interrupted by intermittent precipitation or irrigation. It remains unclear whether the δ C values reflect the cumulative duration of intermittent drought or salinity stress. Read More

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http://dx.doi.org/10.1002/rcm.8433DOI Listing
March 2019
2 Reads

The effect of matrix interferences on in situ boron isotope analysis by laser ablation MC-ICP-MS.

Rapid Commun Mass Spectrom 2019 Mar 13. Epub 2019 Mar 13.

School of Ocean and Earth Science, University of Southampton Waterfront Campus, National Oceanography Centre Southampton, European Way, Southampton, SO14 3ZH, UK.

Rationale: Boron isotope analysis of marine carbonates by laser ablation multi-collector inductively coupled plasma mass spectrometry (LA-MC-ICP-MS) offers the potential for rapid sample throughput, and the means to examine micron scale variations in the δ B signatures of fossil skeletons and shells/tests of marine organisms. Existing studies demonstrate an acceptable level of reproducibility is achievable, but also typically show a level of accuracy outside the limits required by most applications. Here we investigate matrix interference effects as a cause of inaccuracy and imprecision. Read More

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http://doi.wiley.com/10.1002/rcm.8432
Publisher Site
http://dx.doi.org/10.1002/rcm.8432DOI Listing
March 2019
3 Reads

Identification of new interferences leached from plastic microcentrifuge tube in electrospray ionization mass spectrometry.

Rapid Commun Mass Spectrom 2019 Mar 12. Epub 2019 Mar 12.

Tea Research Institute, Chinese Academy of Agricultural Sciences, 9 South Meiling Road, Hangzhou, 310008, P. R. China.

Rationale: The incredible sensitivity of the modern mass spectrometry instrument enables scientists to detect a large number of molecules ranging from small organic compounds to biological macromolecules. However, the same sensitivity makes us often face challenges with respect to background interferences and contaminants. The identification and source of these contaminants is very important for reducing background contamination and ensuring the accuracy of the analysis results. Read More

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http://doi.wiley.com/10.1002/rcm.8431
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http://dx.doi.org/10.1002/rcm.8431DOI Listing
March 2019
11 Reads

Reducing Ion Reflections at the Quadrupole Pre-Filter/Mass Filter Boundary: Simulation and Experiment.

Authors:
Bruce A Collings

Rapid Commun Mass Spectrom 2019 Mar 12. Epub 2019 Mar 12.

AB Sciex, Research.

Rationale: Ion reflections at the quadrupole pre-filter/mass filter lead to the trapping of ions within the pre-filter. The trapped ions lead to space charge effects on the transmission of ions through this region which become more of an issue with the development of high sensitivity mass spectrometers which have bright ions beams.

Methods: Simulations were carried out matching the effective potentials at the pre-filter/mass filter boundary to reduce the field gradients across the boundary by reducing the field radius of the pre-filter. Read More

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http://dx.doi.org/10.1002/rcm.8428DOI Listing
March 2019
1 Read

Stabilities of superoxide dismutase and metal-free superoxide dismutase studied by electrospray ionization ion mobility mass spectrometry.

Rapid Commun Mass Spectrom 2019 May;33(9):894-896

National Center of Mass Spectrometry in Changchun and Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.

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http://dx.doi.org/10.1002/rcm.8426DOI Listing
May 2019
1 Read

Quadrupole Pre-Filter/Mass Filter Transmission Profiles: Experiment and Simulation.

Authors:
Bruce A Collings

Rapid Commun Mass Spectrom 2019 Mar 10. Epub 2019 Mar 10.

AB Sciex, Research.

Rationale: Quadrupole pre-filter transmission profiles are shown to be affected by the presence of trapped ions within the pre-filter of a quadrupole mass spectrometer. Trapped ions are the result of ions reflected at the pre-filter/mass filter boundary and lead to space charge effects that can affect the shape of the pre-filter transmission profile, ion beam stability, peak width and peak intensity. The development of high sensitivity mass spectrometers with bright ion beams leads to greater numbers of trapped ions. Read More

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http://dx.doi.org/10.1002/rcm.8427DOI Listing
March 2019
1 Read

A Rapid Method for Determination of the Hydrogen Isotopes of H O in micro-inclusions by Cr-EA-IRMS.

Rapid Commun Mass Spectrom 2019 Mar 8. Epub 2019 Mar 8.

Key Laboratory of Mineral Resources, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing, 100029, China.

Rationale: The study of hydrogen isotope in fluid inclusions is of great significance in the evolution of ore deposits, speleothem research and fluid migration. Conventional analysis methods are based on off-line thermal decrepitation or mechanical crushing followed by dual-inlet mass spectrometry (DI-IRMS). Because a large sample size (at least 1g) is required for the conventional methods, the hydrogen isotope analysis of small-sized quartz samples is challenging. Read More

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http://dx.doi.org/10.1002/rcm.8430DOI Listing
March 2019
1 Read

Trial analysis of drug profiling by LC/MS and ICPMS to establish the origin of ephedrines used as precursors for illicit production of methamphetamine.

Rapid Commun Mass Spectrom 2019 Mar 8. Epub 2019 Mar 8.

Faculty of Pharma-Science, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan.

Rationale: We investigated whether chemical information on the origin of ephedrine and pseudoephedrine (ephedrines) can be acquired by LC/MS as a substitute method for stable isotope ratio mass spectrometry (IRMS), which is not routinely available in forensic laboratories. We examined the characteristic inorganic elemental contaminants of ephedrines as a preliminary study.

Methods: The stable isotope ratios measured by IRMS analysis are expressed relative to the stable isotope ratio of conventional standards. Read More

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http://dx.doi.org/10.1002/rcm.8429DOI Listing
March 2019
1 Read

Peptide quantification in elemental mass spectrometry using a photoclevable MeCAT reagent.

Rapid Commun Mass Spectrom 2019 Mar 5. Epub 2019 Mar 5.

Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Str. 2, 12489, Berlin, Germany.

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http://dx.doi.org/10.1002/rcm.8425DOI Listing
March 2019
1 Read

A Nanoparticle Co-matrix for Multiple Charging in MALDI Imaging of Tissue.

Rapid Commun Mass Spectrom 2019 Mar 1. Epub 2019 Mar 1.

Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana, 70803, USA.

Rationale: A two-component matrix of 2-nitrophloroglucinol (2-NPG) and silica nanoparticles was used for matrix-assisted laser desorption ionization mass spectrometry imaging of high charge state biomolecules in tissue. Potential applications include increased effective mass range and efficiency of fragmentation.

Methods: A mixture of 2-NPG matrix and silica nanoparticles was applied to cyrosectioned 10 μm thick mouse brain tissue. Read More

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http://dx.doi.org/10.1002/rcm.8424DOI Listing
March 2019
5 Reads

Tracking alterations of alkyl side chains of N species in heavy crude oil after anaerobic biodegradation with negative-ion electrospray ionization coupled with high-field Fourier transform ion cyclotron resonance mass spectrometry.

Rapid Commun Mass Spectrom 2019 May;33(9):875-882

School of Petroleum Engineering, Yangtze University, Wuhan, Hubei, 430010, China.

Rationale: Heteroatomic compounds are relatively abundant and believed to be bio-resistant in heavy crude oils. However, few studies have focused on the biodegradation of these heteroatomic compounds.

Methods: Heteroatoms, especially N species, in a blank crude oil and in three treated oils co-incubated with anaerobic sulfate-reducing bacteria, nitrate-reducing bacteria and fermentative consortia cultures were detected using negative-ion electrospray ionization coupled with high-field Fourier transform ion cyclotron resonance mass spectrometry. Read More

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http://dx.doi.org/10.1002/rcm.8422DOI Listing
May 2019
1 Read
2.253 Impact Factor

Mass Spectrometric Quantification for the Binding Ratio of Metal-Based Anticancer Complexes with Protein Thiols.

Rapid Commun Mass Spectrom 2019 Feb 27. Epub 2019 Feb 27.

Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.

Rationale: The binding ratio of metal complexes with cysteinyl thiols in proteins plays an important role in deciphering the action mechanisms of therapeutic metal complexes, but its analysis is still a big challenge. In this work, a quantitative mass spectrometry method is developed to determine the binding ratio of metal-based anticancer complexes with cysteines in human copper chaperone proteins Atox1.

Methods: A novel strategy based on a thiol-specific stable isotopic labelling reagent was developed to determine the binding ratio of metal based anticancer complexes such as cisplatin and an organometallic ruthenium complex [(η -biphenyl)RuCl (en)]PF (en = ethylenediamine) with the cysteinyl residues of Atox1. Read More

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http://doi.wiley.com/10.1002/rcm.8423
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http://dx.doi.org/10.1002/rcm.8423DOI Listing
February 2019
11 Reads

Adduct ion formation as a tool for the molecular structure assessment of ten isomers in Traveling Wave- and Trapped- Ion Mobility Spectrometry.

Rapid Commun Mass Spectrom 2019 Feb 27. Epub 2019 Feb 27.

Maastricht Multimodal Molecular Imaging (M4I) Institute, Maastricht University, Universiteitssingel 50, 6229, ER, Maastricht, The Netherlands.

Rationale: The separation of isomeric compounds with major differences in physiochemical and pharmacokinetic properties are of particular importance in pharmaceutical R&D. However, the structural assessment and separation of these compounds with current analytical techniques and methods are still a challenge. In this study, we described strategies to separate the various structural- and stereo- isomers. Read More

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http://dx.doi.org/10.1002/rcm.8419DOI Listing
February 2019
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Differentiation of isomeric heptylamines by in-source collision-induced dissociation of [M + H] ions.

Rapid Commun Mass Spectrom 2019 May;33(9):848-856

Centre for Advanced Technologies, Adam Mickiewicz University, Umultowska 89c, 61-614, Poznán, Poland.

Rationale: 1,3-Dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA) and 2-aminoheptane are isomeric heptylamines commonly used as stimulants. The fragmentations of their [M + H] ions (m/z 116) are almost identical and consist of the formation of a fragment ion C H at m/z 57. It is interesting to check if analysis of electrospray ionization (ESI) mass spectra of these three amines enables their differentiation. Read More

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http://dx.doi.org/10.1002/rcm.8421DOI Listing
May 2019
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Rapid screening methods for yeast sub-metabolome analysis on a high-resolution IM-QTOF mass spectrometer.

Rapid Commun Mass Spectrom 2019 Feb 22. Epub 2019 Feb 22.

Department of Chemistry, University of Natural Resources and Life Sciences - BOKU Vienna, Muthgasse 18, 1190, Vienna, Austria.

Rationale: The wide chemical diversity and complex matrices inherent to metabolomics still poses a challenge to current analytical approaches for metabolite screening. Although dedicated front-end separation techniques combined with HRMS set the benchmark from an analytical point of view, the increasing number of samples and sample complexity demand for a compromise in terms of selectivity, sensitivity and high-throughput analyses.

Methods: Prior to low-field drift tube ion mobility separation and QTOFMS detection, rapid UHPLC separation was used for analysis of different concentration levels of dansylated metabolites present in a yeast cell extract. Read More

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http://dx.doi.org/10.1002/rcm.8420DOI Listing
February 2019
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Supercharging and multiple reaction monitoring of high-molecular-weight intact proteins using triple quadrupole mass spectrometry.

Rapid Commun Mass Spectrom 2019 May;33(9):821-830

Department of Chemistry and Biochemistry, The University of Texas Arlington, Arlington, TX, USA.

Rationale: Different supercharging agents were tested to study their effect on the intensity and charge state distributions of high-molecular-weight intact proteins. The goal of this work was to increase chargeability and ionization efficiency for proteins ranging from 66 to 150 kDa, to enable subsequent optimization of multiple reaction monitoring (MRM) mode transitions with a triple quadrupole mass spectrometer for potential top-down quantitative analysis.

Methods: Supercharging agents, such as meta-nitrobenzyl alcohol (m-NBA), dimethylsulfoxide, trifluoroethanol (TFE), and sulfolane were tested in different concentrations in 50/50 acetonitrile/water with 0. Read More

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http://dx.doi.org/10.1002/rcm.8418DOI Listing
May 2019
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Multiple isotope tracers in fur keratin discriminate between mothers and offspring.

Rapid Commun Mass Spectrom 2019 Feb 20. Epub 2019 Feb 20.

Leibniz Institute for Zoo and Wildlife Research, Alfred-Kowalke- Str. 17, 10315, Berlin, Germany.

Rationale: Isoscape origin models for mammals may be impaired by fractionation and routing of isotopes during lactation. Here, we tested if the stable carbon, nitrogen and hydrogen ratios of juvenile bats differ from those of their mothers and if derived isotopic dietary niches and geographical assignments vary accordingly between mothers and juveniles.

Methods: During the post-lactation period, we collected fur of juvenile and female common noctule bats (Nyctalus noctula) from the same maternity roost. Read More

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http://dx.doi.org/10.1002/rcm.8417DOI Listing
February 2019
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Stable isotope measurements to differentiate sources of monofluoroacetate in a blackmail case.

Rapid Commun Mass Spectrom 2019 May;33(9):839-847

Isotrace Research, Department of Chemistry, University of Otago, Dunedin, New Zealand.

Rationale: Stable isotope ratios can provide a 'fingerprint' to enable differentiation of sources of monofluoroacetate (MFA), hence providing a means to eliminate potential sources of MFA in a blackmail case involving the contamination of milk.

Methods: The stable isotopic compositions (δ H, δ C and δ O values) of a library of 43 samples of MFA were determined and multivariate models constructed to differentiate samples of different composition. The data from the MFA library were compared with those obtained from MFA extracted from contaminated milk powder (the case samples). Read More

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http://dx.doi.org/10.1002/rcm.8416DOI Listing
May 2019
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Separation of biologically relevant isomers on an Orbitrap mass spectrometer using high-resolution drift tube ion mobility and varied drift gas mixtures.

Rapid Commun Mass Spectrom 2019 Feb 17. Epub 2019 Feb 17.

Excellims Corporation, Acton, MA, USA.

Rationale: Atmospheric pressure drift tube ion mobility is a powerful addition to the Orbitrap mass spectrometer enabling direct separation of isomers. Apart from offering high resolving power in a compact design, it also facilitates optimization of the separation gas, as shown here for a series of biologically relevant isomer pairs.

Methods: An Excellims MA3100 High-Resolution Atmospheric Pressure Ion Mobility Spectrometer (HR-IMS) was coupled to a Thermo Scientific™ Q Exactive™ Focus hybrid quadrupole-Orbitrap™ mass spectrometer, using an Excellims Directspray™ Electrospray Ionization source and a gas mixture setup to provide various drift gases (air, CO and mixtures). Read More

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http://dx.doi.org/10.1002/rcm.8414DOI Listing
February 2019
18 Reads