7,666 results match your criteria Ramsay Hunt Syndrome


Staphylococcal Plasmids, Transposable and Integrative Elements.

Microbiol Spectr 2018 Nov;6(6)

School of Pharmacy and Biomedical Sciences and Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6102, Australia.

Strains of , and to a lesser extent other staphylococcal species, are a significant cause of morbidity and mortality. An important factor in the notoriety of these organisms stems from their frequent resistance to many antimicrobial agents used for chemotherapy. This review catalogues the variety of mobile genetic elements that have been identified in staphylococci, with a primary focus on those associated with the recruitment and spread of antimicrobial resistance genes. Read More

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November 2018

Characterisation of barley resistance to rhynchosporium on chromosome 6HS.

Theor Appl Genet 2018 Dec 13. Epub 2018 Dec 13.

The James Hutton Institute, Invergowrie, Dundee, DD2 5DA, Scotland, UK.

Key Message: Major resistance gene to rhynchosporium, Rrs18, maps close to the telomere on the short arm of chromosome 6H in barley. Rhynchosporium or barley scald caused by a fungal pathogen Rhynchosporium commune is one of the most destructive and economically important diseases of barley in the world. Testing of Steptoe × Morex and CIho 3515 × Alexis doubled haploid populations has revealed a large effect QTL for resistance to R. Read More

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December 2018
1 Read

REASSURED diagnostics to inform disease control strategies, strengthen health systems and improve patient outcomes.

Nat Microbiol 2019 Jan 13;4(1):46-54. Epub 2018 Dec 13.

London School of Hygiene and Tropical Medicine, London, England.

Lack of access to quality diagnostics remains a major contributor to health burden in resource-limited settings. It has been more than 10 years since ASSURED (affordable, sensitive, specific, user-friendly, rapid, equipment-free, delivered) was coined to describe the ideal test to meet the needs of the developing world. Since its initial publication, technological innovations have led to the development of diagnostics that address the ASSURED criteria, but challenges remain. Read More

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January 2019

Clinical Outcomes After Combined Anterior Cruciate Ligament and Anterolateral Ligament Reconstruction.

Tech Orthop 2018 Dec 25;33(4):225-231. Epub 2017 Dec 25.

Centre Orthopédique Santy, FIFA Medical Centre of Excellence, Groupe Ramsay-Générale de Santé, Hôpital Privé Jean Mermoz, Lyon, France.

Background: Graft rupture rate, return to sport and persistent rotational instability remain a concern postoperatively following anterior cruciate ligament (ACL) reconstruction. The anterolateral ligament (ALL) has recently been shown to act as a lateral knee stabilizer that helps improve rotational stability. To improve functional and clinical outcomes, a combined ACL reconstruction with an associated ALL reconstruction has been proposed. Read More

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December 2018

The spinal and cerebral profile of adult spinal-muscular atrophy: A multimodal imaging study.

Neuroimage Clin 2018 Nov 28. Epub 2018 Nov 28.

Sorbonne Université, CNRS, INSERM, Laboratoire d'Imagerie Biomédicale, Paris, France; APHP, Département de Neurologie, Hôpital Pitié-Salpêtrière, Centre référent SLA, Paris, France; Northern Ireland Centre for Stratified Medicine, Biomedical Sciences Research Institute Ulster University, C-TRIC, Altnagelvin Hospital, Derry, Londonderry, United Kingdom. Electronic address:

Spinal muscular atrophy (SMA) type III and IV are autosomal recessive, slowly progressive lower motor neuron syndromes. Nevertheless, wider cerebral involvement has been consistently reported in mouse models. The objective of this study is the characterisation of spinal and cerebral pathology in adult forms of SMA using multimodal quantitative imaging. Read More

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November 2018

Self-Reported Sensory Impairments and Changes in Cognitive Performance: A Longitudinal 6-Year Follow-Up Study of English Community-Dwelling Adults Aged ⩾50 Years.

J Aging Health 2018 Dec 6:898264318815391. Epub 2018 Dec 6.

3 Queen Mary University of London, UK.

Objective: To investigate the influence of single and dual sensory impairments prospectively on cognition in adults aged ⩾50 years.

Method: Community-dwelling English adults ( n = 4,621) were followed up from 2008 to 2014. Self-reported hearing and vision were collected in 2008. Read More

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December 2018

Comparison of the Post-Caesarean Analgesic Effect of Adding Dexmedetomidine to Paracetamol and Ketorolac: A Randomized Clinical Trial.

Anesth Pain Med 2018 Oct 31;8(5):e85311. Epub 2018 Oct 31.

Pain Research Center, Iran University of Medical Sciences, Tehran, Iran.

Background: Paracetamol and non-steroidal anti-inflammatory drugs (e.g. ketorolac) can be considered for mild to moderate post-caesarean pain. Read More

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October 2018

Takotsubo cardiomyopathy occurring during the recovery period of dobutamine stress echocardiography.

J Cardiol Cases 2012 Jun 19;5(3):e155-e159. Epub 2012 Apr 19.

Cooper Clinic, Dallas, TX, USA.

An 83-year-old Caucasian female was referred for dobutamine stress echocardiography. At peak dobutamine stress, no chest pain was elicited, and there were no ischemic electrocardiographic changes or inducible wall motion abnormalities. During recovery, however, the patient experienced chest burning, and ST-elevations were seen on recovery electrocardiography. Read More

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Implementation of the transradial approach as an alternative vascular access for transcatheter aortic valve replacement guidance: Experience from a high-volume center.

Catheter Cardiovasc Interv 2018 Dec 10. Epub 2018 Dec 10.

Ramsay Générale de Santé, Institut Cardiovasculaire Paris Sud, Massy, Paris, France.

Objective: This study sought to assess the potential benefits of the transradial approach (TRA) as an alternative vascular access to the classical contralateral femoral approach for transcatheter aortic valve replacement (TAVR).

Background: Vascular and bleeding complications in TAVR have gradually decreased owing to operator experience and downsizing of the delivery system. However, about 1/4 of vascular access site complications are related to the transfemoral (TF) secondary access. Read More

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December 2018
2.107 Impact Factor

Complete Genome Sequence of Stenotrophomonas maltophilia AB550, an Environmental Solar Radiation- and Multidrug-Resistant Strain Isolated in Western Australia.

Microbiol Resour Announc 2018 Aug 9;7(5). Epub 2018 Aug 9.

Curtin Water Quality Research Centre, Curtin University, Perth, Western Australia, Australia.

We report here the complete genome sequence of Stenotrophomonas maltophilia AB550, a multidrug- and solar radiation-resistant strain isolated from the effluents of an urban wastewater treatment plant in Western Australia. The genome consists of a single 4.9-Mb chromosome. Read More

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Complete Genome Sequence of a Staphylococcus aureus Sequence Type 612 Isolate from an Australian Horse.

Microbiol Resour Announc 2018 Aug 2;7(4). Epub 2018 Aug 2.

Curtin Health Innovation Research Institute and School of Pharmacy and Biomedical Sciences, Curtin University, Perth, Western Australia, Australia.

Staphylococcus aureus is a serious pathogen of humans and animals. Multilocus sequence type 612 is dominant and highly virulent in South African hospitals but relatively uncommon elsewhere. We present the complete genome sequence of methicillin-resistant Staphylococcus aureus strain SVH7513, isolated from a horse at a veterinary clinic in New South Wales, Australia. Read More

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Comparison of the Effect of Bupivacaine in Combination with Dexmedetomidine with Bupivacaine Plus Placebo on Neonatal Apgar Score, Bispectral Index, and Sedation Level of Parturient Women.

Anesth Pain Med 2018 Oct 24;8(5):e81947. Epub 2018 Oct 24.

Department of Anesthesiology and Critical Care, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: In this study, we aimed to compare the effects of bupivacaine alone and in combination with dexmedetomidine on postoperative analgesia, neonatal Apgar score, and bispectral index (BIS), which has been shown to correlate with increased sedation and loss of consciousness in women undergoing cesarean section under spinal anesthesia.

Methods: A total of 152 term parturient women scheduled to have elective cesarean section with American Society of Anesthesiologist (ASA) physical status I or II were allocated randomly into two groups to receive either bupivacaine plus placebo (BV group) or bupivacaine plus dexmedetomidine (BVD group). BIS, sedation scale scores, Apgar scores, and hemodynamic characteristics were recorded and statistically compared between the groups. Read More

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October 2018

Anterior and middle pelvic organ prolapse repair using a six tension-free strap low weight transvaginal mesh: long-term retrospective monocentric study of 311 patients.

J Gynecol Obstet Hum Reprod 2018 Nov 30. Epub 2018 Nov 30.

Hôpital Privé Sainte Marie, Groupe Ramsay General de Sante, Chalon sur Saône, France. Electronic address:

Introduction: Treatment of pelvic organ prolapse is an important public health issue due to the ageing population. The Food and Drug Administration, in 2011, issued a warning on complications after transvaginal insertion of high weight mesh. We evaluated a 6 tension-free straps, light prosthesis made from polypropylene monofilaments. Read More

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November 2018
1 Read

A Roberts Syndrome individual with differential genotoxin sensitivity and a DNA damage response defect.

Int J Radiat Oncol Biol Phys 2018 Nov 30. Epub 2018 Nov 30.

Cancer Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia; Clinical Pathology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address:

Purpose: Roberts Syndrome (RBS) is a rare recessively-transmitted developmental disorder characterized by growth retardation, craniofacial abnormalities and truncation of limbs. All affected individuals to date have mutations in the ESCO2 (Establishment of cohesion 2) gene, a key regulator of the cohesin complex, which is involved in sister chromatid cohesion and DNA double-strand break (dsb) repair. Here we characterize DNA damage responses (DDRs) for the first time in a RBS-affected family. Read More

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November 2018
2 Reads

Liver Iron Load Influences Hepatic Fat Fraction in End-Stage Renal Disease Patients on Dialysis: A Proof of Concept Study.

EBioMedicine 2018 Nov 27. Epub 2018 Nov 27.

Division of Radiology, Ramsay Générale de Santé, Hôpital Privé Claude Galien, Quincy-Sous-Sénart, France.

Background: Nonalcoholic fatty liver disease (NAFLD) is a spectrum of diseases including steatosis, nonalcoholic steatohepatitis (NASH), cirrhosis, and end-stage liver failure. Hepatic iron accumulation has been linked to hepatic fibrosis severity in NASH and NAFLD. Iron overload induced by parenteral (IV) iron therapy is a potential clinical problem in dialysis patients. Read More

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November 2018
2 Reads

Evolution of ST-Elevation Acute Myocardial Infarction Prevalence by Gender Assessed Age Pyramid Analysis-The Piramyd Study.

J Clin Med 2018 Dec 3;7(12). Epub 2018 Dec 3.

SAMU 93, UF Recherche-Enseignement-Qualité Avicenne Hospital-APHP, 93000 Bobigny, France.

Introduction: Recent studies reported a decrease in the incidence of acute myocardial infarction. This favorable evolution does not extend to young women. The interaction between gender, risk factors and myocardial infarction incidence remains controversial. Read More

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December 2018

Ultrasonography and clinical outcomes following anti-incontinence procedures (Monarc vs MiniArc): A 3-year post-operative review.

PLoS One 2018 4;13(12):e0207375. Epub 2018 Dec 4.

Department of Obstetrics & Gynecology, Subang Jaya Medical Center, Ramsay Sime Darby Health Care, Selangor, Malaysia.

Objective: To compare the ultrasonographic positional changes of mid-urethral sling(MUS) tape in relation to symphysis pubis, and the different clinical outcomes among women who underwent MUS insertion with MiniArcTM or MonarcTM for the treatment of stress urinary incontinence 3 years after.

Materials And Methods: A retrospective follow-up study on patients with clinically confirmed stress urodynamic incontinence and urodynamic stress incontinence who had undergone MiniArc or Monarc surgery. Data regarding preoperative evaluation, intraoperative complications and post-operative follow-ups were collated. Read More

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December 2018
1 Read
3.234 Impact Factor

Apixaban to Prevent Venous Thromboembolism in Patients with Cancer.

N Engl J Med 2018 Dec 4. Epub 2018 Dec 4.

From the Department of Medicine, University of Ottawa, Ottawa Hospital Research Institute, Ottawa (M.C., R.M., G.G., G.L.G., D.S., T.R., M.R., D.W., P.S.W.), Centre Intégré de Santé et des Services Sociaux de l'Outaouais, Gatineau, QC (K.A.-N.), Jewish General Hospital, Lady Davis Institute for Medical Research, McGill University, Montreal (V.T.), Nova Scotia Health Authority, Halifax (S. Shivakumar), Lakeridge Health, Oshawa, ON (A.S.), William Osler Health Centre, Brampton, ON (P.K.), Sault Area Hospital, Sault Ste. Marie, ON (D.H., S. Spadafora), Hôpital Régional de Rimouski, Rimouski, QC (K.M.), Markham Stouffville Hospital, Markham, ON (M.T.), Kingston General Hospital, Kingston, ON (A.T.), University of British Columbia, British Columbia Cancer Agency, Vancouver (A.Y.Y.L.), Hamilton Health Sciences, Hamilton, ON (P.L.G.), London Health Sciences Centre, London, ON (A.L.-L.), and Royal Victoria Regional Health Centre, Barrie, ON (R.E.-M.) - all in Canada.

Background: Patients with active cancer have an increased risk of venous thromboembolism, which results in substantial morbidity, mortality, and health care expenditures. The Khorana score (range, 0 to 6, with higher scores indicating a higher risk of venous thromboembolism) has been validated to identify patients with cancer at elevated risk for this complication and may help select those who could benefit from thromboprophylaxis.

Methods: We conducted a randomized, placebo-controlled, double-blind clinical trial assessing the efficacy and safety of apixaban (2. Read More

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December 2018
2 Reads
5 Citations
18.000 Impact Factor

Impact of coronary artery disease and percutaneous coronary intervention in women undergoing transcatheter aortic valve replacement: From the WIN-TAVI registry.

Catheter Cardiovasc Interv 2018 Dec 4. Epub 2018 Dec 4.

Icahn School of Medicine at Mount Sinai, New York, New York.

Objectives: To evaluate the impact of coronary artery disease (CAD) with or without recent (≤ 30 days) percutaneous coronary intervention (PCI) in women undergoing transcatheter aortic valve replacement (TAVR).

Background: Although women display a specific risk-profile for both PCI and TAVR, the impact of CAD and PCI in the setting of TAVR in women is unclear.

Methods: The multinational Women's International Transcatheter Aortic Valve implantation registry enrolled consecutive female patients undergoing contemporary TAVR in 19 centers between 2013 and 2015. Read More

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December 2018
4 Reads

Healthcare leadership with political astuteness (HeLPA): a qualitative study of how service leaders understand and mediate the informal 'power and politics' of major health system change.

BMC Health Serv Res 2018 Dec 3;18(1):918. Epub 2018 Dec 3.

Department of Applied Health Research, University College London, 1-19 Torrington Place, Fitzrovia, London, WC1E 7HB, UK.

Background: The implementation of strategic health system change is often complicated by the informal politics and power of health systems, such as competing interests and resistant groups. Evidence from other industries shows that strategic leaders need to be aware of and manage such 'organisational politics' when implementing change, which involves developing and using forms of political 'skill', 'savvy' or 'astuteness'. The purpose of this study is to investigate the acquisition, use and contribution of political 'astuteness' in the implementation of strategic health system change. Read More

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December 2018
1 Read

The burden of dyslipidaemia and factors associated with lipid levels among adults in rural northern Ghana: An AWI-Gen sub-study.

PLoS One 2018 28;13(11):e0206326. Epub 2018 Nov 28.

Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Dyslipidaemia is a primary risk factor for cardiometabolic disease, causing over 17 million deaths globally in 2015. However, the burden of dyslipidaemia and factors associated with lipid levels remain unknown in many rural African populations. Therefore, this study evaluated the association of socio-demographic, anthropometric and behavioural factors with lipid levels in rural Ghana. Read More

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November 2018
2 Reads

[Combination of clonidine-bupivacaine in caudal epidural anesthesia for hypospadias surgery in children: prospective, randomized, blind study].

Rev Bras Anestesiol 2018 Oct 25. Epub 2018 Oct 25.

Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Belo Horizonte, MG, Brasil; Faculdade de Minas (Faminas), Belo Horizonte, MG, Brasil. Electronic address:

Background And Objectives: The combination of clonidine with local anesthetic administered for epidural anesthesia via caudal route seems to improve the quality of postoperative analgesia, but with conflicting results. This study compared the postoperative analgesia of three different doses of clonidine combined with bupivacaine in caudal epidural anesthesia in children undergoing hypospadias repair.

Methods: Eighty children aged 1 to 10 years, candidates for surgical repair of hypospadias, were randomly divided into four groups of 20 patients to receive general anesthesia combined with caudal epidural anesthesia with bupivacaine 0. Read More

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October 2018
1 Read

Invasive meningococcal disease as a cause of sudden and unexpected death in a teenager: The public health importance of confirming the diagnosis.

J Infect 2018 Nov 23. Epub 2018 Nov 23.

Public Health England, Immunisation and Countermeasures Division, 61 Colindale Avenue, London NW9 5EQ, UK. Electronic address:

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November 2018
1 Read

Hip Hip Hooray, ECT turns 80!

Authors:
Patrick Clarke

Australas Psychiatry 2018 Nov 26:1039856218815753. Epub 2018 Nov 26.

Senior Clinical Lecturer, The University of Adelaide, Adelaide, SA, and; Director of Transcranial Magnetic Stimulation, Ramsay Health, North Adelaide, SA, Australia.

Objective:: This paper reviews the history of electroconvulsive therapy (ECT) with an emphasis on the Australian context over the past 30 years. The review includes data collection, the contribution of the RANZCP, and changes in legislation.

Conclusion:: ECT remains the most effective treatment for severe depression. Read More

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November 2018
1 Read

[Incidental deep vein thrombosis during EBUS].

Rev Mal Respir 2018 Nov 22. Epub 2018 Nov 22.

Service de pneumologie, hôpital privé La Louvière, Ramsay Générale de Santé, 69, rue de la Louvière, 59000 Lille, France.

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November 2018
3 Reads

Single-Molecule Observation of the Intermediates in a Catalytic Cycle.

J Am Chem Soc 2018 Nov 26. Epub 2018 Nov 26.

The development of catalysts benefits from knowledge of the intermediate steps that accelerate the transformations of substrates into products. However, key transient species are often hidden in ensemble measurements. Here, we show that the continuous single-molecule observation of a reaction in solution can be performed by using a protein nanoreactor that samples the intermediate steps in a catalytic cycle. Read More

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November 2018
3 Reads

Can peri-ovulatory putrescine supplementation improve egg quality in older infertile women?

J Assist Reprod Genet 2018 Nov 22. Epub 2018 Nov 22.

Ottawa Hospital Research Institute, The Ottawa Hospital-General Campus, 501 Smyth Road, Box 511, Ottawa, K1H 8L6, Canada.

The aging-related decline in fertility is an increasingly pressing medical and economic issue in modern society where women are delaying family building. Increasingly sophisticated, costly, and often increasingly invasive, assisted reproductive clinical protocols and laboratory technologies (ART) have helped many older women achieve their reproductive goals. Current ART procedures have not been able to address the fundamental problem of oocyte aging, the increased rate of egg aneuploidy, and the decline of developmental potential of the eggs. Read More

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November 2018
9 Reads

1-Year Outcomes With the Evolut R Self-Expanding Transcatheter Aortic Valve: From the International FORWARD Study.

JACC Cardiovasc Interv 2018 Nov;11(22):2326-2334

Department of Innovative Interventions in Cardiology, University of Bonn, Bonn, Germany.

Objectives: This study sought to report the 1-year safety and efficacy outcomes in the FORWARD (CoreValve Evolut R FORWARD) study following transcatheter aortic valve replacement (TAVR) with the next-generation Evolut R device (Medtronic, Minneapolis, Minnesota) in routine clinical practice.

Background: The FORWARD study reported low incidences of mortality, disabling stroke, and significant paravalvular leak following TAVR in routine clinical practice at 30 days. Longer-term results in large patient populations with the Evolut R self-expanding, repositionable transcatheter heart valve (THV) are lacking. Read More

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November 2018
2 Reads

Is Liver Ultrasound Useful as Part of the Surveillance Strategy following Potentially Curative Colorectal Cancer Resection?

Dig Dis 2018 Nov 22:1-5. Epub 2018 Nov 22.

Department of General Surgery, Aberdeen Royal Infirmary, Aberdeen, United Kingdom.

Background: Optimal surveillance monitoring following curative resection of colorectal cancer remains unclear. Guidelines recommend computed tomography (CT)-based imaging for the initial 3 years following surgical intervention due to the high rates of local and distant recurrence. However, there is currently limited supporting evidence for this strategy. Read More

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November 2018
4 Reads

Are Changes in Medical Group Practice Characteristics Over Time Associated With Medicare Spending and Quality of Care?

Med Care Res Rev 2018 Nov 22:1077558718812939. Epub 2018 Nov 22.

4 UC-Berkeley School of Public Health, Berkeley, CA, USA.

Physician practices have been growing in size, and becoming more commonly owned by hospitals, over time. We use survey data on physician practices surveyed at two points in time, linked to Medicare claims data, to investigate whether changes in practice size or ownership are associated with changes in the use of care management, health information technology (HIT), or quality improvement processes. We find that practice growth and becoming hospital-owned are associated with adoption of more quality improvement processes, but not with care management or HIT. Read More

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November 2018
1 Read

Trigeminal herpes zoster and Ramsay Hunt syndrome in an elderly adult: Presentation with prodromal toothache.

Gerodontology 2018 Sep;35(3):276-278

Department of Internal Medicine, Sinai Hospital of Baltimore, Baltimore, MD, USA.

Objective: This article describes an atypical herpes zoster (HZ) infection heralded by prodromic dental pain.

Background: Trigeminal HZ is associated with any of the three divisions of the trigeminal nerve, and Ramsay Hunt syndrome is a rare variant of HZ infection of the ear, often accompanied with unilateral facial nerve palsy.

Materials And Methods: An 87-year-old man sought remedy for tooth-like pain. Read More

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September 2018
1 Read

Preparation of Barley Pollen Mother Cells for Confocal and Super Resolution Microscopy.

Methods Mol Biol 2019 ;1900:167-179

Cell and Molecular Sciences, The James Hutton Institute, Dundee, Scotland, UK.

Recombination (crossover) drives the release of genetic diversity in plant breeding programs. However, in barley, recombination is skewed toward the telomeric ends of its seven chromosomes, restricting the re-assortment of about 30% of the genes located in the centromeric regions of its large 5.1 Gb genome. Read More

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January 2019

Changing times: Fluorescence-lifetime analysis of amyloidogenic SF-IAPP fusion protein.

J Struct Biol 2018 Nov 17. Epub 2018 Nov 17.

Department of Molecular Genetics, Federal State Budgetary Scientific Institution "Institute of Experimental Medicine", 197376 Akademika Pavlova St. 12, St. Petersburg, Russia; Department of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute named by B. P. Konstantinov of National Research Center "Kurchatov Institute", 188300 mkr. Orlova roshcha 1, Gatchina, Russia; Department of Molecular Biology of Viruses, Smorodintsev Research Institute of Influenza, Ministry of Healthcare of the Russian Federation, 197376 Prof. Popov St. 15/17, St. Petersburg, Russia.

In a number of conformational diseases, intracellular accumulation of proteins bearing non-native conformations occurs. The search for compounds that are capable of hindering the formation and accumulation of toxic protein aggregates and fibrils is an urgent task. Present fluorescent methods of fibrils' detection prevent simple real-time observations. Read More

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November 2018
7 Reads
3.231 Impact Factor

Electrical Stimulation and Recovery of Gastrointestinal Function Following Surgery: A Systematic Review.

Neuromodulation 2018 Nov 19. Epub 2018 Nov 19.

Faculty of Medical and Health Sciences, Department of Surgery, The University of Auckland, Auckland, New Zealand.

Objectives: Postoperative ileus occurs in approximately 5-15% of patients following major abdominal surgery, and poses a substantial clinical and economic burden. Electrical stimulation has been proposed as a means to aid postoperative gastrointestinal (GI) recovery, but no methods have entered routine clinical practice. A systematic review was undertaken to assess electrical stimulation techniques and to evaluate their clinical efficacy in order to identify promising areas for future research. Read More

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November 2018
5 Reads

Obituary: Professor Graham Ramsay.

Intensive Care Med 2018 Dec 15;44(12):2274-2275. Epub 2018 Nov 15.

Anaesthesia and Intensive Care Medicine, Imperial College Healthcare NHS Trust, London, UK.

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December 2018

Bacterial colonization of healthcare workers' mobile phones in the ICU and effectiveness of sanitization.

J Occup Environ Hyg 2018 Nov 15:1-7. Epub 2018 Nov 15.

a Ramsay-Générale de Santé , Hôpital Privé Claude Galien , Service de Réanimation Polyvalente , F-91480 , Quincy-sous-Sénart , France.

Extra-European studies report high rates of multi-drug resistant bacteria colonization of healthcare workers' mobile phones in intensive care units. We aimed to assess the prevalence of bacterial colonization of healthcare workers' mobile phones in an intensive care unit in France and the effectiveness of a sanitization product. We designed a prospective, monocentric study in a 15-bed intensive care unit within a 300-bed private hospital. Read More

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November 2018
6 Reads

Comparison of different sufentanil-tramadol combinations for pain relief within the first 24 hours after cesarean section: a retrospective study.

J Pain Res 2018 23;11:2445-2451. Epub 2018 Oct 23.

Department of Anesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China,

Introduction: Postcesarean section pain management is important for both the mother and the newborn. This study compared the analgesic effects and incidence of adverse events associated with intravenous patient-controlled analgesia (iv-PCA), using different sufentanil-tramadol combinations for postoperative pain control.

Methods: Parturients (n=5,794) who had been scheduled for cesarean section under neuraxial anesthesia and had received iv-PCA between September 2013 and March 2017 were retrospectively analyzed. Read More

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October 2018

Transcatheter Aortic Valve Replacement in the Catheterization Laboratory Versus Hybrid Operating Room: Insights From the FRANCE TAVI Registry.

JACC Cardiovasc Interv 2018 Nov;11(21):2195-2203

Paris South Cardiovascular Institute, Jacques-Cartier Private Hospital, Ramsay Générale de Santé, Massy, France.

Objectives: This study sought to compare outcomes of patients undergoing transcatheter aortic valve replacement (TAVR) in a catheterization laboratory (cath lab) to those undergoing TAVR in a hybrid operating room (OR).

Background: TAVR can be performed in a cath lab or in a hybrid OR. Comparisons between these locations are scarce. Read More

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November 2018
4 Reads

Not all hyperphosphataemias should be treated.

Nephrol Dial Transplant 2018 Nov 6. Epub 2018 Nov 6.

Department of Rheumatology, INSERM U1132 & USPC Paris-Diderot, Hôpital Lariboisière, Paris, France.

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November 2018

Ultrasound-Guided Surgery for Carpal Tunnel Syndrome: A New Interventional Procedure.

Semin Intervent Radiol 2018 Oct 5;35(4):248-254. Epub 2018 Nov 5.

Service de Chirurgie Orthopédique, Hôpital Lariboisière, AP-HP, Paris, France.

Carpal tunnel syndrome (CTS) may be treated surgically if medical treatment fails. The classical approach involves release of the flexor retinaculum by endoscopic or open surgery. Meta-analyses have shown that the risk of nerve injury may be higher with endoscopic treatment. Read More

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October 2018
9 Reads

DELTA guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial.

Trials 2018 Nov 5;19(1):606. Epub 2018 Nov 5.

Health Economics Group, Institute of Health & Society, Newcastle University, Newcastle upon Tyne, NE2 4AX, UK.

Background: A key step in the design of a RCT is the estimation of the number of participants needed in the study. The most common approach is to specify a target difference between the treatments for the primary outcome and then calculate the required sample size. The sample size is chosen to ensure that the trial will have a high probability (adequate statistical power) of detecting a target difference between the treatments should one exist. Read More

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November 2018
5 Reads

Dexmedetomidine is safe and reduces the additional dose of midazolam for sedation during endoscopic retrograde cholangiopancreatography in very elderly patients.

BMC Gastroenterol 2018 Nov 6;18(1):166. Epub 2018 Nov 6.

Division of Gastroenterology, Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.

Background: Endoscopic retrograde cholangiopancreatography (ERCP) often requires deep sedation. Dexmedetomidine, a highly selective α2-adrenoceptor agonist with sedative activity and minimal effects on respiration, has recently been widely used among patients in the intensive care unit. However, its use in endoscopic procedures in very elderly patients is unclear. Read More

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November 2018
6 Reads

Cholangioscopic diagnostic classification of bile duct lesions: a worthwhile task, not an easy one.

Endoscopy 2018 Nov 6;50(11):1049-1050. Epub 2018 Nov 6.

Gastroenterology, Jean Mermoz Hospital, Lyon, Ramsay Générale de Santé, France.

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November 2018
5 Reads

Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans.

Nucleic Acids Res 2018 Nov 5. Epub 2018 Nov 5.

Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

During haematopoiesis, haematopoietic stem cells differentiate into restricted potential progenitors before maturing into the many lineages required for oxygen transport, wound healing and immune response. We have updated Haemopedia, a database of gene-expression profiles from a broad spectrum of haematopoietic cells, to include RNA-seq gene-expression data from both mice and humans. The Haemopedia RNA-seq data set covers a wide range of lineages and progenitors, with 57 mouse blood cell types (flow sorted populations from healthy mice) and 12 human blood cell types. Read More

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November 2018
9 Reads
9.112 Impact Factor

[You're only as old as your arteries!]

Authors:
H Benamer P Assayag

Ann Cardiol Angeiol (Paris) 2018 Dec 30;67(6):399-400. Epub 2018 Oct 30.

Hôpital Kremlin-Bicètre, AP-HP, 78, rue du Général-Leclerc, 94270 Le Kremlin-Bicêtre, France.

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December 2018

Propofol sparing effect of dexmedetomidine and magnesium sulfate during BIS targeted anesthesia: A prospective, randomized, placebo controlled trial.

J Anaesthesiol Clin Pharmacol 2018 Jul-Sep;34(3):335-340

Department of Anaesthesiology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India.

Background And Aims: Maintenance of adequate depth of anesthetic is crucial to prevent awareness and to reduce stress response associated with surgery. Goals of balanced general anesthetic are met by use of adjuvants to facilitate use of lower anesthetic dose, while ensuring adequate anesthetic depth. This study employed BIS monitoring to compare the anesthetic sparing effects of intravenous dexmedetomidine and magnesium sulphate on induction dose of propofol by maintaining a BIS value of 40-50. Read More

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November 2018
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HLA-DRB1 Amino Acid Positions and Residues Associated with Antibody-positive Rheumatoid Arthritis in Black South Africans.

J Rheumatol 2018 Nov 1. Epub 2018 Nov 1.

From the Division of Rheumatology, and Division of Human Genetics, Faculty of Health Sciences, and the Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA; University of Cape Town, Cape Town, South Africa. This work was made possible by grants from Carnegie Corporation of New York (B8749), the Connective Tissue Diseases Fund, the University of the Witwatersrand, and the Medical Research Council of South Africa to Dr. Tikly. Dr. Ramsay received financial support from the National Research Foundation of South Africa. Dr. Reynolds was supported by US National Institutes of Health grant K01 AR060848. N. Govind, PhD, Division of Rheumatology, University of the Witwatersrand; R.J. Reynolds, PhD, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham; B. Hodkinson, PhD, University of Cape Town; C. Ickinger, MBBCh, Division of Rheumatology, University of the Witwatersrand; M. Ramsay, PhD, Sydney Brenner Institute for Molecular Bioscience, and Division of Human Genetics, Faculty of Health Sciences, University of the Witwatersrand; S.L. Bridges Jr., PhD, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham; M. Tikly, PhD, Division of Rheumatology, University of the Witwatersrand. Address correspondence to N. Govind, Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Faculty of Health Sciences, Johannesburg, South Africa. E-mail: Accepted for publication July 20, 2018.

Objective: To investigate the association of specific amino acid positions, residues, and haplotypes of HLA-DRB1 in black South Africans with autoantibody-positive rheumatoid arthritis (RA).

Methods: High-resolution genotyping was performed in 266 black South Africans with autoantibody-positive RA and 362 ethnically and geographically matched controls. The alleles were converted to specific amino acid residues at polymorphic sites for downstream analyses. Read More

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November 2018
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ASO Author Reflections: Immunotherapy for Solid Tumors: A Review.

Ann Surg Oncol 2018 Oct 30. Epub 2018 Oct 30.

Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

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October 2018
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Position paper of French Interventional Group (GACI) for TAVI in France in 2018.

Ann Cardiol Angeiol (Paris) 2018 Dec 28;67(6):455-465. Epub 2018 Oct 28.

Department of cardiology, Gabriel Montpied hospital, Clermont-Ferrand university hospital, 58, rue Montalembert, 63003 Clermont-Ferrand cedex 1, France.

Aortic stenosis is a frequent disease in the elderly. Its prevalence is 0.4% with a sharp increase after the age of 65, and its outcome is very poor when the patient becomes symptomatic. Read More

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December 2018
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